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Autism RCT

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https://www.readbyqxmd.com/read/27918841/community-effectiveness-rct-of-a-comprehensive-psychosocial-treatment-for-high-functioning-children-with-asd
#1
Marcus L Thomeer, Christopher Lopata, James P Donnelly, Adam Booth, Andrew Shanahan, Veronica Federiconi, Christin A McDonald, Jonathan D Rodgers
This community effectiveness randomized clinical trial examined the feasibility and effectiveness of a comprehensive psychosocial treatment, summerMAX, when implemented by a community agency. Fifty-seven high-functioning children (48 male, 9 female), ages 7-12 years with autism spectrum disorder participated in this study. The 5-week summerMAX treatment included instruction and therapeutic activities targeting social/social-communication skills, interpretation of nonliteral language skills, face-emotion recognition skills, and interest expansion...
December 5, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27868194/randomized-controlled-trial-of-vitamin-d-supplementation-in-children-with-autism-spectrum-disorder
#2
Khaled Saad, Ahmed A Abdel-Rahman, Yasser M Elserogy, Abdulrahman A Al-Atram, Amira A El-Houfey, Hisham A K Othman, Geir Bjørklund, Feiyong Jia, Mauricio A Urbina, Mohamed Gamil M Abo-Elela, Faisal-Alkhateeb Ahmad, Khaled A Abd El-Baseer, Ahmed E Ahmed, Ahmad M Abdel-Salam
BACKGROUND: Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. METHODS: This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3-10 years)...
November 21, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27084832/feasibility-of-a-trial-on-improvisational-music-therapy-for-children-with-autism-spectrum-disorder
#3
Monika Geretsegger, Ulla Holck, Łucja Bieleninik, Christian Gold
BACKGROUND: To conduct generalizable, rigorously designed, adequately powered trials investigating music therapy and other complex interventions, it is essential that study procedures are feasible and acceptable for participants. To date, only limited evidence on feasibility of trial designs and strategies to facilitate study implementation is available in the music therapy literature. OBJECTIVE: Using data from a subsample of a multi-center RCT on improvisational music therapy (IMT) for autism spectrum disorder (ASD), this study aims to evaluate feasibility of study procedures, evaluate safety, document concomitant treatment, and report consistency of individuals' trends over time in chosen outcome measures...
2016: Journal of Music Therapy
https://www.readbyqxmd.com/read/27027666/transcranial-direct-current-stimulation-in-child-and-adolescent-psychiatry
#4
Débora Muszkat, Guilherme Vanoni Polanczyk, Taciana G Costa Dias, André Russowsky Brunoni
OBJECTIVES: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that consists of applying a weak electric current over the scalp to modulate cortical excitability. tDCS has been extensively investigated in adults with psychiatric disorders. The aim of this study was to review the current literature regarding the use of tDCS in children and adolescents with psychiatric disorders. METHODS: We searched MEDLINE and EMBASE databases for studies evaluating the safety and efficacy of tDCS in children and adolescents from age 0 to 18 years with psychiatric disorders...
September 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26792796/social-stories%C3%A2-to-alleviate-challenging-behaviour-and-social-difficulties-exhibited-by-children-with-autism-spectrum-disorder-in-mainstream-schools-design-of-a-manualised-training-toolkit-and-feasibility-study-for-a-cluster-randomised-controlled-trial-with
#5
REVIEW
Barry Wright, David Marshall, Joy Adamson, Hannah Ainsworth, Shehzad Ali, Victoria Allgar, Danielle Collingridge Moore, Elizabeth Cook, Paul Dempster, Lisa Hackney, Dean McMillan, Dominic Trepél, Chris Williams
BACKGROUND: A Social Story™ (Carol Gray) is a child-friendly intervention that is used to give children with autism spectrum disorders (ASDs) social information in situations where they have social difficulties. Limited evidence mainly using single-case designs suggests that they can reduce anxiety and challenging behaviour. OBJECTIVES: The objectives were to conduct a systematic review, use this to develop a manualised intervention and run a feasibility trial to inform a fully powered randomised controlled trial (RCT) on their clinical effectiveness and cost-effectiveness in schools...
January 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/26577969/behavioral-benefits-of-camel-milk-in-subjects-with-autism-spectrum-disorder
#6
RANDOMIZED CONTROLLED TRIAL
Laila Y Al-Ayadhi, Dost Muhammad Halepoto, Abdul M Al-Dress, Yasmine Mitwali, Rana Zainah
OBJECTIVE: To investigate the possible therapeutic effects of camel milk on behavioral characteristics as an interventional strategy in autistic children. STUDY DESIGN: Double-blind, Randomized Clinical Trial (RCT). PLACE AND DURATION OF STUDY: Autism Research and Treatment Center, Al-Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2012 to May 2013...
November 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/26404701/depression-in-adolescents-with-asd-a-pilot-rct-of-a-group-intervention
#7
RANDOMIZED CONTROLLED TRIAL
Damian Santomauro, Jeanie Sheffield, Kate Sofronoff
Depression is a potentially life threatening affective disorder that is highly prevalent in individuals with autism spectrum disorders (ASD). This study aimed to evaluate the feasibility, acceptability and preliminary efficacy of a cognitive behavioural intervention for depression in adolescents with ASD. Participants were randomly assigned to the intervention group, or wait-list control group. Although recruitment was extremely difficult, attendance was favourable and attrition was low, and participants reported being satisfied with the programme...
February 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/26310577/study-protocol-a-randomized-controlled-trial-investigating-the-effects-of-a-psychosexual-training-program-for-adolescents-with-autism-spectrum-disorder
#8
RANDOMIZED CONTROLLED TRIAL
Kirsten Visser, Kirstin Greaves-Lord, Nouchka T Tick, Frank C Verhulst, Athanasios Maras, Esther J M van der Vegt
BACKGROUND: Previous research shows that adolescents with autism spectrum disorder (ASD) run several risks in their psychosexual development and that these adolescents can have limited access to reliable information on puberty and sexuality, emphasizing the need for specific guidance of adolescents with ASD in their psychosexual development. Few studies have investigated the effects of psychosexual training programs for adolescents with ASD and to date no randomized controlled trials are available to study the effects of psychosexual interventions for this target group...
2015: BMC Psychiatry
https://www.readbyqxmd.com/read/26129831/the-effect-of-the-video-game-mindlight-on-anxiety-symptoms-in-children-with-an-autism-spectrum-disorder
#9
RANDOMIZED CONTROLLED TRIAL
Lieke A M W Wijnhoven, Daan H M Creemers, Rutger C M E Engels, Isabela Granic
BACKGROUND: In the clinical setting, a large proportion of children with an autism spectrum disorder (ASD) experience anxiety symptoms. Because anxiety is an important cause of impairment for children with an ASD, it is necessary that effective anxiety interventions are implemented for these children. Recently, a serious game called Mindlight has been developed that is focused on decreasing anxiety in children. This approach is based on recent research suggesting that video games might be suitable as an intervention vehicle to enhance mental health in children...
2015: BMC Psychiatry
https://www.readbyqxmd.com/read/26036646/managing-repetitive-behaviours-in-young-children-with-autism-spectrum-disorder-asd-pilot-randomised-controlled-trial-of-a-new-parent-group-intervention
#10
RANDOMIZED CONTROLLED TRIAL
Victoria Grahame, Denise Brett, Linda Dixon, Helen McConachie, Jessica Lowry, Jacqui Rodgers, Nick Steen, Ann Le Couteur
Early intervention for autism spectrum disorder (ASD) tends to focus on enhancing social-communication skills. We report the acceptability, feasibility and impact on child functioning of a new 8 weeks parent-group intervention to manage restricted and repetitive behaviours (RRB) in young children with ASD aged 3-7 years. Forty-five families took part in the pilot RCT. A range of primary and secondary outcome measures were collected on four occasions (baseline, 10, 18 and 24 weeks) to capture both independent ratings and parent-reported changes in RRB...
October 2015: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/25367544/parent-implemented-social-intervention-for-toddlers-with-autism-an-rct
#11
RANDOMIZED CONTROLLED TRIAL
Amy M Wetherby, Whitney Guthrie, Juliann Woods, Christopher Schatschneider, Renee D Holland, Lindee Morgan, Catherine Lord
OBJECTIVES: To compare the effects of two 9-month parent-implemented interventions within the Early Social Interaction (ESI) Project. Both individual-ESI, offered 2 or 3 times per week at home or in the community, and group-ESI, offered once per week in a clinic, taught parents how to embed strategies to support social communication throughout everyday activities. METHODS: Participants in the randomized controlled trial included 82 children diagnosed with autism spectrum disorder at 16 to 20 months...
December 2014: Pediatrics
https://www.readbyqxmd.com/read/25132516/a-randomised-controlled-trial-of-pegasus-a-psychoeducational-programme-for-young-people-with-high-functioning-autism-spectrum-disorder
#12
RANDOMIZED CONTROLLED TRIAL
Kate Gordon, Marianna Murin, Ozlem Baykaner, Laura Roughan, Vaan Livermore-Hardy, David Skuse, Will Mandy
BACKGROUND: Psychoeducation is an essential component of postdiagnostic care for people with ASD (autism spectrum disorder), but there is currently no evidence base for clinical practice. We designed, manualised and evaluated PEGASUS (psychoeducation group for autism spectrum understanding and support), a group psychoeducational programme aiming to enhance the self-awareness of young people with ASD by teaching them about their diagnosis. METHODS: This single-blind RCT (randomised control trial) involved 48 young people (9-14 years) with high-functioning ASD...
April 2015: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/24989854/a-randomized-controlled-study-of-a-social-skills-training-for-preadolescent-children-with-autism-spectrum-disorders-generalization-of-skills-by-training-parents-and-teachers
#13
RANDOMIZED CONTROLLED TRIAL
Vera Dekker, Maaike H Nauta, Erik J Mulder, Marieke E Timmerman, Annelies de Bildt
BACKGROUND: Social skills training (SST) is a common intervention for children with autism spectrum disorders (ASDs) to improve their social and communication skills. Despite the fact that SSTs are often applied in clinical practice, the evidence for the effectiveness of these trainings for children with ASD is inconclusive. Moreover, long term outcome and generalization of learned skills are little evaluated. Additionally, there is no research on the influence of involvement of parents and teachers on effectiveness of SST and on the generalization of learned social skills to daily life...
2014: BMC Psychiatry
https://www.readbyqxmd.com/read/24958585/caregiver-mediated-intervention-for-low-resourced-preschoolers-with-autism-an-rct
#14
RANDOMIZED CONTROLLED TRIAL
Connie Kasari, Kathy Lawton, Wendy Shih, Tyson V Barker, Rebecca Landa, Catherine Lord, Felice Orlich, Bryan King, Amy Wetherby, Damla Senturk
OBJECTIVES: To compare 2 short-term, community caregiver training interventions for preschool-aged children with Autism Spectrum Disorder who had low resources. Low resource was defined by the US Department of Housing and Urban Development low-income index or 1 "indicator," (e.g., Medicaid eligibility). Child outcomes focused on joint engagement, joint attention, and play. METHODS: Participants included 112 families of a child who had Autism Spectrum Disorder who met criteria for being low-resourced and who were randomly assigned to 1 of 2 3-month interventions, group caregiver education or individualized caregiver-mediated intervention (CMM)...
July 2014: Pediatrics
https://www.readbyqxmd.com/read/24936966/music-therapy-for-people-with-autism-spectrum-disorder
#15
REVIEW
Monika Geretsegger, Cochavit Elefant, Karin A Mössler, Christian Gold
BACKGROUND: The central impairments of people with autism spectrum disorder (ASD) affect social interaction and communication. Music therapy uses musical experiences and the relationships that develop through them to enable communication and expression, thus attempting to address some of the core problems of people with ASD. The present version of this review on music therapy for ASD is an update of the original Cochrane review published in 2006. OBJECTIVES: To assess the effects of music therapy for individuals with ASD...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24408892/a-randomized-controlled-trial-of-the-korean-version-of-the-peers-%C3%A2-parent-assisted-social-skills-training-program-for-teens-with-asd
#16
RANDOMIZED CONTROLLED TRIAL
Hee-Jeong Yoo, Geonho Bahn, In-Hee Cho, Eun-Kyung Kim, Joo-Hyun Kim, Jung-Won Min, Won-Hye Lee, Jun-Seong Seo, Sang-Shin Jun, Guiyoung Bong, Soochurl Cho, Min-Sup Shin, Bung-Nyun Kim, Jae-Won Kim, Subin Park, Elizabeth A Laugeson
Impaired social functioning is a hallmark feature of autism spectrum disorder (ASD), often requiring treatment throughout the life span. PEERS(®) (Program for the Education and Enrichment of Relational Skills) is a parent-assisted social skills training for teens with ASD. Although PEERS(®) has an established evidence base in improving the social skills of adolescents and young adults with ASD in North America, the efficacy of this treatment has yet to be established in cross-cultural validation trials. The objective of this study is to examine the feasibility and treatment efficacy of a Korean version of PEERS(®) for enhancing social skills through a randomized controlled trial (RCT)...
February 2014: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/24083413/teacch-based-group-social-skills-training-for-children-with-high-functioning-autism-a-pilot-randomized-controlled-trial
#17
Kayoko Ichikawa, Yoshimitsu Takahashi, Masahiko Ando, Tokie Anme, Tatsuro Ishizaki, Hinako Yamaguchi, Takeo Nakayama
BACKGROUND: Although social skills training programs for people with high-functioning autism (HFA) are widely practiced, the standardization of curricula, the examination of clinical effectiveness, and the evaluation of the feasibility of future trials have yet to be done in Asian countries. To compensate for this problem, a Japanese pilot randomized controlled trial (RCT) of the Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH)-based group social skills training for children with HFA and their mothers was conducted...
2013: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/24050741/second-generation-antipsychotics-in-asperger-s-disorder-and-high-functioning-autism-a-systematic-review-of-the-literature-and-effectiveness-of-meta-analysis
#18
REVIEW
Natalie Sochocky, Robert Milin
OBJECTIVE: Second generation antipsychotics (SGA) have gained increased evidence for the treatment of irritability and aggression in children and adolescents with lower functioning autistic disorder. Individuals with Asperger's Disorder (AD) and High Functioning Autism (HFA) experience significant emotional and behavioral problems and psychiatric comorbidity. There is a need to review the published literature on SGA treatment efficacy in the AD and HFA populations to provide more effective treatment choices for these subgroups...
November 2013: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/23993773/behavioral-parent-training-to-address-sleep-disturbances-in-young-children-with-autism-spectrum-disorder-a-pilot-trial
#19
RANDOMIZED CONTROLLED TRIAL
Cynthia R Johnson, Kylan S Turner, Emily Foldes, Maria M Brooks, Rebecca Kronk, Luci Wiggs
OBJECTIVES: A large percentage of children with autism spectrum disorders (ASD) have bedtime and sleep disturbances. However, the treatment of these disturbances has been understudied. The purpose of our study was to develop a manualized behavioral parent training (BPT) program for parents of young children with ASD and sleep disturbances and to test the feasibility, fidelity, and initial efficacy of the treatment in a small randomized controlled trial (RCT). PARTICIPANTS AND METHODS: Parents of a sample of 40 young children diagnosed with ASD with an average age of 3...
October 2013: Sleep Medicine
https://www.readbyqxmd.com/read/23228230/second-generation-antipsychotics-for-the-treatment-of-disruptive-behaviour-disorders-in-children-a-systematic-review
#20
REVIEW
Tamara Pringsheim, Daniel Gorman
OBJECTIVE: The use of second-generation antipsychotics (SGAs) in youth has increased considerably. Increases are mainly attributable to treatment of disruptive behaviour disorders (DBDs). Our objective was to review the evidence regarding the efficacy of SGAs for DBDs in youth. METHOD: We performed a systematic review of all randomized controlled trials (RCTs) of SGAs and placebo for the treatment of DBDs in youth, focusing on efficacy data. RESULTS: Eight RCTs in youth with DBDs were included...
December 2012: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
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