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Autism RCT

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https://www.readbyqxmd.com/read/29742275/early-intensive-behavioral-intervention-eibi-for-young-children-with-autism-spectrum-disorders-asd
#1
REVIEW
Brian Reichow, Kara Hume, Erin E Barton, Brian A Boyd
BACKGROUND: The rising prevalence of autism spectrum disorders (ASD) increases the need for evidence-based behavioral treatments to lessen the impact of symptoms on children's functioning. At present, there are no curative or psychopharmacological therapies to effectively treat all symptoms of the disorders. Early intensive behavioral intervention (EIBI) is a treatment based on the principles of applied behavior analysis. Delivered for multiple years at an intensity of 20 to 40 hours per week, it is one of the more well-established treatments for ASD...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29624206/paracetamol-acetaminophen-for-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-infants
#2
REVIEW
Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA). A PDA can be treated surgically; or medically with one of two prostaglandin inhibitors, indomethacin or ibuprofen. Case reports suggest that paracetamol may be an alternative for the closure of a PDA. An association between prenatal or postnatal exposure to paracetamol and later development of autism or autism spectrum disorder has been reported...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29609630/rationale-and-design-for-cognitive-behavioral-therapy-for-anxiety-disorders-in-children-with-autism-spectrum-disorder-a-study-protocol-of-a-randomized-controlled-trial
#3
Tina R Kilburn, Merete Juul Sørensen, Mikael Thastum, Ronald M Rapee, Charlotte Ulrikka Rask, Kristian Bech Arendt, Per Hove Thomsen
BACKGROUND: Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, social and general development as well as quality of life. The main goal of this study is to examine the effectiveness of a manualized cognitive behavioral therapy (CBT) anxiety program adapted for children with ASD...
April 2, 2018: Trials
https://www.readbyqxmd.com/read/29568212/effectiveness-of-cognitive-behavioral-therapy-for-individuals-with-autism-spectrum-disorders-and-comorbid-obsessive-compulsive-disorder-a-review-of-the-research
#4
Leman Kaniturk Kose, Lise Fox, Eric A Storch
Autism spectrum disorders (ASD) and obsessive-compulsive disorder (OCD) are highly comorbid, precipitating an urgent need to identify evidence-based practices that might be used to address this comorbidity exclusively. The aim of this study was to conduct a review of intervention research and clinical reports to examine the use of cognitive behavioral therapy (CBT) with individuals who have comorbid ASD and OCD. Based on the pre-determined review inclusion criteria, 11 studies were included in the review: three randomized control trials (RCT), one case controlled study, two single subject experimental designs, and five case studies...
February 2018: Journal of Developmental and Physical Disabilities
https://www.readbyqxmd.com/read/29527682/peer-mediated-intervention-to-improve-play-skills-in-children-with-autism-spectrum-disorder-a-feasibility-study
#5
Cally Kent, Reinie Cordier, Annette Joosten, Sarah Wilkes-Gillan, Anita Bundy
BACKGROUND/AIM: Children with autism spectrum disorder (ASD) frequently demonstrate impaired play skills and poor quality social interactions compared to typically developing peers. Complex interventions to improve play skills should be investigated with randomised control trials (RCT) where possible to support evidence-based practice for occupational therapists. Prior to a RCT, multiple feasibility studies are recommended to identify barriers to the trial. The aim of this study is to adapt a complex intervention to improve play skills in children with ASD and investigate the feasibility of conducting a RCT...
March 11, 2018: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29484149/randomised-controlled-trial-of-simvastatin-treatment-for-autism-in-young-children-with-neurofibromatosis-type-1-santa
#6
Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X Castellanos, Alcino J Silva, Sue Huson, Stephen Williams, D Gareth Evans, Richard Emsley, Jonathan Green
Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29325223/maternal-thyroid-hormone-insufficiency-during-pregnancy-and-risk-of-neurodevelopmental-disorders-in-offspring-a-systematic-review-and-meta-analysis
#7
William Thompson, Ginny Russell, Genevieve Baragwanath, Justin Matthews, Bijay Vaidya, Jo Thompson-Coon
BACKGROUND: In the last 2 decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results. AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes...
April 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29203509/protocol-for-a-feasibility-study-and-randomised-pilot-trial-of-a-low-intensity-psychological-intervention-for-depression-in-adults-with-autism-the-autism-depression-trial-adept
#8
Ailsa Russell, Kate Cooper, Stephen Barton, Ian Ensum, Daisy Gaunt, Jeremy Horwood, Barry Ingham, David Kessler, Chris Metcalfe, Jeremy Parr, Dheeraj Rai, Nicola Wiles
INTRODUCTION: High rates of co-occurring depression are reported in autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social communication impairments and repetitive behaviours. Cognitive-behavioural interventions adapted for ASD have been effective for anxiety problems. There have been evaluation studies of group cognitive-behavioural therapy for co-occurring depression, but no randomised trials investigating low-intensity psychological interventions as recommended in clinical guidelines for mild-moderate depression...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28942807/a-randomized-placebo-controlled-trial-of-metformin-for-the-treatment-of-overweight-induced-by-antipsychotic-medication-in-young-people-with-autism-spectrum-disorder-open-label-extension
#9
Benjamin L Handen, Evdokia Anagnostou, Michael G Aman, Kevin B Sanders, James Chan, Jill A Hollway, Jessica Brian, L Eugene Arnold, Lucia Capano, Craig Williams, Jessica A Hellings, Eric Butter, Deepali Mankad, Rameshwari Tumuluru, Jessica Kettel, Cassandra R Newsom, Naomi Peleg, Dina Odrobina, Sarah McAuliffe-Bellin, Sarah Marler, Taylor Wong, Alexis Wagner, Stasia Hadjiyannakis, Eric A Macklin, Jeremy Veenstra-VanderWeele
OBJECTIVE: A previous study reported on a 16-week placebo-controlled, randomized clinical trial (RCT) of metformin for weight stabilization in 61 children and adolescents 6 to 17 years old with autism spectrum disorder who were prescribed atypical antipsychotics. The present study describes the results of a 16-week open-label extension. METHOD: Fifty-two participants from the acute trial (85%) entered the extension; 22 had been on metformin during the initial RCT and 30 had been on placebo...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28884333/supplement-intervention-associated-with-nutritional-deficiencies-in-autism-spectrum-disorders-a-systematic-review
#10
Yong-Jiang Li, Ya-Min Li, Da-Xiong Xiang
PURPOSE: Nutritional supplements have been used for correction of deficiencies that may occur in patient with autism spectrum disorder (ASD) and to improve core symptoms. We aim to provide current best evidence about supplements for nutritional deficiencies and core symptoms in children with ASD and to evaluate the effectiveness and safety. METHODS: A systematic literature search of scientific databases was performed to retrieve relevant randomized controlled trials...
September 7, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28645986/feasibility-study-of-a-randomised-controlled-trial-to-investigate-the-effectiveness-of-using-a-humanoid-robot-to-improve-the-social-skills-of-children-with-autism-spectrum-disorder-kaspar-rct-a-study-protocol
#11
Silvana E Mengoni, Karen Irvine, Deepshikha Thakur, Garry Barton, Kerstin Dautenhahn, Karen Guldberg, Ben Robins, David Wellsted, Shivani Sharma
INTRODUCTION: Interventions using robot-assisted therapy may be beneficial for the social skills development of children with autism spectrum disorder (ASD); however, randomised controlled trials (RCTs) are lacking. The present research aims to assess the feasibility of conducting an RCT evaluating the effectiveness of a social skills intervention using Kinesics and Synchronisation in Personal Assistant Robotics (Kaspar) with children with ASD. METHODS AND ANALYSIS: Forty children will be recruited...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28626020/lack-of-effect-of-vitamin-d-3-supplementation-in-autism-a-20-week-placebo-controlled-rct
#12
RANDOMIZED CONTROLLED TRIAL
Conor P Kerley, Clare Power, Louise Gallagher, David Coghlan
OBJECTIVES: Data suggest a potential role for vitamin D in autism spectrum disorder (ASD). We wanted to assess the effect of vitamin D3 supplementation compared with placebo in children with ASD. DESIGN: This was a double-blind, randomised, placebo-controlled trial. SETTING: A paediatric outpatient centre at high latitude over the winter season in Dublin, Ireland (53°N). PATIENTS: 42 children with ASD. INTERVENTIONS: 2000 IU vitamin D3 supplementation or placebo daily for 20 weeks...
November 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28574669/cross-site-randomized-control-trial-of-the-social-abcs-caregiver-mediated-intervention-for-toddlers-with-autism-spectrum-disorder
#13
Jessica A Brian, Isabel M Smith, Lonnie Zwaigenbaum, Susan E Bryson
To evaluate the efficacy of the Social ABCs parent-mediated intervention for toddlers with suspected or confirmed autism spectrum disorder (ASD), through a cross-site randomized control trial, sixty-three parent-toddler dyads (toddler age: 16-30 months) were randomized into treatment (Social ABCs) or control (service-as-usual) conditions. Video data were obtained at three key time-points: Baseline; Post-training (PT; week 12); and Follow-Up (week 24). Analyses included 62 dyads. Treatment allocation significantly accounted for PT gains, all favouring the Treatment group, in (1) child functional vocal responsiveness to parent prompts (R2  = 0...
October 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28562286/nutritional-and-dietary-interventions-for-autism-spectrum-disorder-a-systematic-review
#14
REVIEW
Nila Sathe, Jeffrey C Andrews, Melissa L McPheeters, Zachary E Warren
CONTEXT: Children with autism spectrum disorder (ASD) frequently use special diets or receive nutritional supplements to treat ASD symptoms. OBJECTIVES: Our objective was to evaluate the effectiveness and safety of dietary interventions or nutritional supplements in ASD. DATA SOURCES: Databases, including Medline and PsycINFO. STUDY SELECTION: Two investigators independently screened studies against predetermined criteria...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28543302/a-randomised-controlled-trial-of-an-ipad-based-application-to-complement-early-behavioural-intervention-in-autism-spectrum-disorder
#15
Andrew J O Whitehouse, Joanna Granich, Gail Alvares, Margherita Busacca, Matthew N Cooper, Alena Dass, Thi Duong, Rajes Harper, Wendy Marshall, Amanda Richdale, Tania Rodwell, David Trembath, Pratibha Vellanki, Dennis W Moore, Angelika Anderson
BACKGROUND: Technology-based interventions for Autism Spectrum Disorder (ASD) have proliferated, but few have been evaluated within the context of a randomised controlled trial (RCT). This RCT evaluated the efficacy of one technology-based early intervention programme (Therapy Outcomes By You; TOBY) in young children with ASD. METHODS: TOBY is an app-based learning curriculum designed for children and parents as a complement to early behavioural intervention. Eighty children (16 female) were recruited to this RCT within 12 months of receiving a diagnosis of ASD (M age = 3...
May 25, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28454928/community-partnered-research-with-urban-school-districts-that-serve-children-with-autism-spectrum-disorder
#16
Tristram Smith, Suzannah Iadarola, David S Mandell, Robin Harwood, Connie Kasari
OBJECTIVE: To illustrate the process of community-partnered participatory research to develop and evaluate interventions for children with autism in urban school districts. METHODS: We formed partnerships of school personnel, parents, and researchers to guide the project. We then conducted focus groups, key informant interviews, and town halls to explore how public schools currently serve students with autism. We used findings from these activities to adapt interventions for public schools...
August 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28393350/randomised-trial-of-a-parent-mediated-intervention-for-infants-at-high-risk-for-autism-longitudinal-outcomes-to-age-3-years
#17
Jonathan Green, Andrew Pickles, Greg Pasco, Rachael Bedford, Ming Wai Wan, Mayada Elsabbagh, Vicky Slonims, Teea Gliga, Emily Jones, Celeste Cheung, Tony Charman, Mark Johnson
BACKGROUND: There has been increasing interest in the potential for pre-emptive interventions in the prodrome of autism, but little investigation as to their effect. METHODS: A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention...
December 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28391453/moderating-effects-of-parental-characteristics-on-the-effectiveness-of-a-theory-of-mind-training-for-children-with-autism-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Danielle M J de Veld, Patricia Howlin, Elske Hoddenbach, Fleur Mulder, Imke Wolf, Hans M Koot, Ramón Lindauer, Sander Begeer
This RCT investigated whether the effect of a Theory of Mind (ToM) intervention for children with ASD was moderated by parental education level and employment, family structure, and parental ASD. Children with autism aged 8-13 years (n = 136) were randomized over a waitlist control or treatment condition. At posttest, children in the treatment condition had more ToM knowledge, showed fewer autistic features, and more ToM-related behavior than children in the control condition. Children who had one or two parents with at least a college degree, and children with parents not diagnosed with/suspected of having ASD themselves benefitted from the training...
July 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28351374/working-memory-training-in-children-with-neuropsychiatric-disorders-and-mild-to-borderline-intellectual-functioning-the-role-of-coaching-a-double-blind-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Sammy Roording-Ragetlie, Helen Klip, Jan Buitelaar, Dorine Slaats-Willemse
BACKGROUND: Working memory training (WMT) has been shown to offer therapeutic benefits to both patients with Attention-Deficit Hyperactivity Disorder (ADHD) and patients with mild to borderline Intellectual Disabilities (MBID; 60 < IQ < 85). However, robust evidence for transfer effects and treatment benefits of WMT over placebo training are lacking. Owing to the nature of double-blind research designs in RCTs, children have received non-specific coaching not based on their actual training performance...
March 28, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28217829/vitamin-d-and-autism-what-s-new
#20
REVIEW
John Jacob Cannell
An increasing amount of evidence points to the possibility that gestational and early childhood vitamin D deficiency [25(OH)D < 40 ng/ml] cause some cases of autism. Vitamin D is metabolized into a seco-steroid hormone that regulates about 3% of the 26,000 genes in the coding human genome. It is also a neurosteroid that is active in brain development, having effects on cellular proliferation, differentiation, calcium signaling, neurotrophic and neuroprotective actions; it also appears to have an effect on neurotransmission and synaptic plasticity...
June 2017: Reviews in Endocrine & Metabolic Disorders
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