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https://www.readbyqxmd.com/read/27918841/community-effectiveness-rct-of-a-comprehensive-psychosocial-treatment-for-high-functioning-children-with-asd
#1
Marcus L Thomeer, Christopher Lopata, James P Donnelly, Adam Booth, Andrew Shanahan, Veronica Federiconi, Christin A McDonald, Jonathan D Rodgers
This community effectiveness randomized clinical trial examined the feasibility and effectiveness of a comprehensive psychosocial treatment, summerMAX, when implemented by a community agency. Fifty-seven high-functioning children (48 male, 9 female), ages 7-12 years with autism spectrum disorder participated in this study. The 5-week summerMAX treatment included instruction and therapeutic activities targeting social/social-communication skills, interpretation of nonliteral language skills, face-emotion recognition skills, and interest expansion...
December 5, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27917460/moderators-of-parent-training-for-disruptive-behaviors-in-young-children-with-autism-spectrum-disorder
#2
Luc Lecavalier, Tristram Smith, Cynthia Johnson, Karen Bearss, Naomi Swiezy, Michael G Aman, Denis G Sukhodolsky, Yanhong Deng, James Dziura, Lawrence Scahill
We conducted a 6 month, randomized trial of parent training (PT) versus a parent education program (PEP) in 180 young children (158 boys, 22 girls), ages 3-7 years, with autism spectrum disorder (ASD). PT was superior to PEP in decreasing disruptive and noncompliant behaviors. In the current study, we assess moderators of treatment response in this trial. Thirteen clinical and demographic variables were evaluated as potential moderators of three outcome variables: the Aberrant Behavior Checklist-Irritability subscale (ABC-I), Home Situations Questionnaire (HSQ), and Clinical Global Impressions-Improvement Scale (CGI-I)...
December 5, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27893955/using-a-patient-centered-outcome-measure-to-test-methylphenidate-versus-placebo-in-children-with-autism-spectrum-disorder
#3
Lawrence Scahill, Karen Bearss, Rena Sarhangian, Christopher J McDougle, L Eugene Arnold, Michael G Aman, James T McCracken, Elaine Tierney, Scott Gillespie, Valentina Postorino, Benedetto Vitiello
OBJECTIVES: Parent rating scales are commonly used to evaluate change in clinical trials. Despite advantages, these measures may not capture parental impression of the child's most salient problems. We examine the use of parent target problems (PTPs) in a randomized trial of methylphenidate (MPH) in children with autism spectrum disorder and symptoms of attention-deficit/hyperactivity disorder. METHODS: This multisite, 4-week, randomized crossover trial compared three dose levels (low, medium, and high) of MPH with placebo...
November 28, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27884169/study-protocol-implementation-of-a-computer-assisted-intervention-for-autism-in-schools-a-hybrid-type-ii-cluster-randomized-effectiveness-implementation-trial
#4
Melanie Pellecchia, Rinad S Beidas, Steven C Marcus, Jessica Fishman, John R Kimberly, Carolyn C Cannuscio, Erica M Reisinger, Keiran Rump, David S Mandell
BACKGROUND: The number of children diagnosed with autism has rapidly outpaced the capacities of many public school systems to serve them, especially under-resourced, urban school districts. The intensive nature of evidence-based autism interventions, which rely heavily on one-to-one delivery, has caused schools to turn to computer-assisted interventions (CAI). There is little evidence regarding the feasibility, effectiveness, and implementation of CAI in public schools. While CAI has the potential to increase instructional time for students with autism, it may also result in unintended consequences such as reduction in the amount of interpersonal (as opposed to computerized) instruction students receive...
November 25, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27874271/diagnostic-model-generated-by-mri-derived-brain-features-in-toddlers-with-autism-spectrum-disorder
#5
Xiang Xiao, Hui Fang, Jiansheng Wu, ChaoYong Xiao, Ting Xiao, Lu Qian, FengJing Liang, Zhou Xiao, Kang Kang Chu, Xiaoyan Ke
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with core symptoms of atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests, and activities. Although the pathophysiologic mechanism of ASD is unclarified yet, the neuroanatomical features are considered as valuable predictors for discriminating ASD from others. But there has been relatively little scientific study about predictive power of different neuroanatomical features of early age ASD...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27869148/motor-noise-is-rich-signal-in-autism-research-and-pharmacological-treatments
#6
E B Torres, K Denisova
The human body is in constant motion, from every breath that we take, to every visibly purposeful action that we perform. Remaining completely still on command is a major achievement as involuntary fluctuations in our motions are difficult to keep under control. Here we examine the noise-to-signal ratio of micro-movements present in time-series of head motions extracted from resting-state functional magnetic resonance imaging scans in 1048 participants. These included individuals with autism spectrum disorders (ASD) and healthy-controls in shared data from the Autism Brain Imaging Data Exchange (ABIDE) and the Attention-Deficit Hyperactivity Disorder (ADHD-200) databases...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27868194/randomized-controlled-trial-of-vitamin-d-supplementation-in-children-with-autism-spectrum-disorder
#7
Khaled Saad, Ahmed A Abdel-Rahman, Yasser M Elserogy, Abdulrahman A Al-Atram, Amira A El-Houfey, Hisham A K Othman, Geir Bjørklund, Feiyong Jia, Mauricio A Urbina, Mohamed Gamil M Abo-Elela, Faisal-Alkhateeb Ahmad, Khaled A Abd El-Baseer, Ahmed E Ahmed, Ahmad M Abdel-Salam
BACKGROUND: Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children. METHODS: This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3-10 years)...
November 21, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27862603/defining-the-hidden-evidence-in-autism-research-forty-per-cent-of-rigorously-designed-clinical-trials-remain-unpublished-a-cross-sectional-analysis
#8
Konstantin Mechler, Georg F Hoffmann, Ralf W Dittmann, Markus Ries
Autism spectrum disorders (ASD) have a prevalence of up to 2.7% and show significant rates of comorbidities. Pharmacological treatment can be difficult. New treatment options are needed, several are currently under investigation. Publication bias presents a major problem in current clinical research. This study was designed to quantify publication bias in rigorously designed ASD research. The database at ClinicalTrials.gov was searched for all completed randomized controlled clinical trials investigating interventions in ASD and their results made public...
November 9, 2016: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/27858958/advanced-parental-age-and-autism-risk-in-children-a-systematic-review-and-meta-analysis
#9
S Wu, F Wu, Y Ding, J Hou, J Bi, Z Zhang
OBJECTIVE: Advanced parental age has raised additional concern as a risk factor of autism. We conducted a meta-analysis of observational studies investigating the association between advanced parental age and risk of autism. METHOD: PubMed, EMBASE, and Web of Science were searched for reports published up to November 11, 2015. Risk estimates from individual studies were pooled using random-effects models. RESULTS: Twenty-seven studies were included in the meta-analysis...
November 14, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27857792/omega-3-supplementation-in-autism-spectrum-disorders-a-still-open-question
#10
Annio Posar, Paola Visconti
One of the most commonly used complementary and alternative practices in children with autism spectrum disorder (ASD) is the supplementation of omega-3. We describe the case of a child with ASD who seemed to respond to omega-3 supplementation in a relevant and lasting manner. So far, based on the results of randomized clinical trials, evidence-based medicine negates the effectiveness of omega-3 in ASD children. Nevertheless, considering anecdotal experiences, including that of our patient, and nonrandomized trials, the presence of a subgroup of ASD patients who are really responders to omega-3 cannot be excluded...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27845765/intranasal-oxytocin-enhances-connectivity-in-the-neural-circuitry-supporting-social-motivation-and-social-perception-in-children-with-autism
#11
Ilanit Gordon, Allison Jack, Charlotte M Pretzsch, Brent Vander Wyk, James F Leckman, Ruth Feldman, Kevin A Pelphrey
Oxytocin (OT) has become a focus in investigations of autism spectrum disorder (ASD). The social deficits that characterize ASD may relate to reduced connectivity between brain sites on the mesolimbic reward pathway (nucleus accumbens; amygdala) that receive OT projections and contribute to social motivation, and cortical sites involved in social perception. Using functional magnetic resonance imaging and a randomized, double blind, placebo-controlled crossover design, we show that OT administration in ASD increases activity in brain regions important for perceiving social-emotional information...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27843460/the-relationship-between-zinc-levels-and-autism-a-systematic-review-and-meta-analysis
#12
REVIEW
Nasim Babaknejad, Fatemeh Sayehmiri, Kourosh Sayehmiri, Ashraf Mohamadkhani, Somaye Bahrami
OBJECTIVE: Autism is a complex behaviorally defined disorder.There is a relationship between zinc (Zn) levels in autistic patients and development of pathogenesis, but the conclusion is not permanent. MATERIALS & METHODS: The present study conducted to estimate this probability using meta-analysis method. In this study, Fixed Effect Model, twelve articles published from 1978 to 2012 were selected by searching Google scholar, PubMed, ISI Web of Science, and Scopus and information were analyzed...
2016: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/27834905/-we-dance-and-find-each-other-1-effects-of-dance-movement-therapy-on-negative-symptoms-in-autism-spectrum-disorder
#13
Malin K Hildebrandt, Sabine C Koch, Thomas Fuchs
The treatment of deficits in social interaction, a shared symptom cluster in persons with schizophrenia (negative symptoms) and autism spectrum disorder (DSM-5 A-criterion), has so far remained widely unsuccessful in common approaches of psychotherapy. The alternative approach of embodiment brings to focus body-oriented intervention methods based on a theoretic framework that explains the disorders on a more basic level than common theory of mind approaches. The randomized controlled trial at hand investigated the effects of a 10-week manualized dance and movement therapy intervention on negative symptoms in participants with autism spectrum disorder...
November 10, 2016: Behavioral Sciences
https://www.readbyqxmd.com/read/27830427/factors-associated-with-self-injurious-behaviors-in-children-with-autism-spectrum-disorder-findings-from-two-large-national-samples
#14
G N Soke, S A Rosenberg, R F Hamman, T Fingerlin, C R Rosenberg, L Carpenter, L C Lee, E Giarelli, L D Wiggins, M S Durkin, A Reynolds, C DiGuiseppi
In this study, we explored potential associations among self-injurious behaviors (SIB) and a diverse group of protective and risk factors in children with autism spectrum disorder from two databases: Autism and Developmental Disabilities Monitoring (ADDM) Network and the Autism Speaks-Autism Treatment Network (AS-ATN). The presence of SIB was determined from children's records in ADDM and a parent questionnaire in AS-ATN. We used multiple imputation to account for missing data and a non-linear mixed model with site as a random effect to test for associations...
November 9, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27824638/autism-spectrum-disorder-and-avoidant-restrictive-food-intake-disorder
#15
Jennifer Lucarelli, Demetra Pappas, Leah Welchons, Marilyn Augustyn
Kendra is a 4-year-old girl with autism spectrum disorder (ASD) who presents for follow-up of feeding problems to her pediatric clinician. She is an only child in a family where both parents are scientists. Feeding concerns date to infancy, when she was diagnosed with Gastroesophageal Reflux Disease (GERD) associated with persistent bottle refusal and the acceptance of few pureed foods. At 13 months, milk and peanut allergies were diagnosed. Following a feeding clinic evaluation at 24 months, she was prescribed a soy milk supplement and an H2 blocker...
November 4, 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27816800/interventions-that-target-improvements-in-mental-health-for-parents-of-children-with-autism-spectrum-disorders-a-narrative-review
#16
REVIEW
Nikko S Da Paz, Jan L Wallander
Prevalence of autism spectrum disorders (ASD) suggest that one in 68 children is affected. With convincing evidence that parenting a child with ASD is associated with elevated distress and mental health problems, researchers have begun to investigate treatments that directly target parents' psychological well-being. We conducted a narrative review of studies that empirically tested the effects of interventions targeting improvements in the mental health of parents of children with ASD. Following a range of search strategies, a total of 13 studies, seven randomized controlled trials (RCTs) and six pre-post test designs, met inclusion criteria...
October 27, 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27815645/the-effect-of-pivotal-response-treatment-in-children-with-autism-spectrum-disorders-a-non-randomized-study-with-a-blinded-outcome-measure
#17
E A Duifhuis, J C den Boer, A Doornbos, J K Buitelaar, I J Oosterling, H Klip
Purpose of this quasi-experimental trial was to investigate the effect of Pivotal response treatment (PRT) versus treatment as usual (TAU) on autism symptoms. Children with autism spectrum disorder (ASD), aged 3-8 years, received either PRT (n = 11) or TAU (n = 13). Primary outcome measure was the total score on the Autism Diagnostic Observation Schedule at pre- and posttreatment. Additionally, general problem behavior and parental stress levels were measured. Children in the PRT condition improved on the primary outcome measure compared to the TAU group with a small effect size [partial η(2) = 0...
November 4, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27809407/unique-effects-of-the-transporters-animated-series-and-of-parental-support-on-emotion-recognition-skills-of-children-with-asd-results-of-a-randomized-controlled-trial
#18
Tali Gev, Ruthie Rosenan, Ofer Golan
Emotion recognition (ER) and understanding deficits are characteristic of autism spectrum disorder (ASD). The Transporters (TT) animated series has shown promising results in teaching children with ASD to recognize emotions, with mixed findings about generalization and maintenance of effects. This study aimed to evaluate the unique role of TT and of parental support in the acquisition, generalization, and maintenance of acquired ER skills in children with ASD. 77 Israeli children with high functioning ASD, aged 4-7 were randomly assigned into four groups according to a 2 × 2 design of the factors Series (TT, control series) and Parental Support (with/without)...
November 3, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27807755/an-evaluation-of-a-behaviorally-based-social-skills-group-for-individuals-diagnosed-with-autism-spectrum-disorder
#19
Justin B Leaf, Jeremy A Leaf, Christine Milne, Mitchell Taubman, Misty Oppenheim-Leaf, Norma Torres, Donna Townley-Cochran, Ronald Leaf, John McEachin, Paul Yoder
In this study we evaluated a social skills group which employed a progressive applied behavior analysis model for individuals diagnosed with autism spectrum disorder. A randomized control trial was utilized; eight participants were randomly assigned to a treatment group and seven participants were randomly assigned to a waitlist control group. The social skills group consisted of 32, 2 h sessions. Teachers implemented a variety of behaviorally based procedures. A blind evaluator measured participants' behavior immediately prior to intervention, immediately following intervention, and during 16 and 32-week maintenance probes...
November 2, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27807466/a-systematic-review-of-peer-mediated-interventions-for-children-with-autism-spectrum-disorder
#20
Ya-Chih Chang, Jill Locke
BACKGROUND: Peer mediated intervention (PMI) is a promising practice used to increase social skills in children with autism spectrum disorder (ASD). PMIs engage typically developing peers as social models to improve social initiations, responses, and interactions. METHOD: The current study is a systematic review examining PMIs for children and adolescents with ASD conducted using group designs. Five studies met the pre-specified review inclusion criteria: four randomized controlled trials and one pre- and post-test design...
July 2016: Research in Autism Spectrum Disorders
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