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https://www.readbyqxmd.com/read/28346865/repetitive-transcranial-magnetic-stimulation-for-the-treatment-of-executive-function-deficits-in-autism-spectrum-disorder-clinical-trial-approach
#1
Stephanie H Ameis, Zafiris J Daskalakis, Daniel M Blumberger, Pushpal Desarkar, Irene Drmic, Donald J Mabbott, Meng-Chuan Lai, Paul E Croarkin, Peter Szatmari
OBJECTIVE: Executive function (EF) deficits in patients with autism spectrum disorder (ASD) are ubiquitous and understudied. Further, there are no effective, neuroscience-based treatments to address this impairing feature of ASD. Repetitive transcranial magnetic stimulation (rTMS) has demonstrated promise in addressing EF deficits in adult neuropsychiatric disorders. This article will outline the design of a novel randomized-controlled trial of bilateral, 20 Hz, rTMS applied to the dorsolateral prefrontal cortex (DLPFC) for treatment of EF deficits in ASD that is currently ongoing...
March 27, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28344643/goliah-gaming-open-library-for-intervention-in-autism-at-home-a-6-month-single-blind-matched-controlled-exploratory-study
#2
Anne-Lise Jouen, Antonio Narzisi, Jean Xavier, Elodie Tilmont, Nicolas Bodeau, Valentina Bono, Nabila Ketem-Premel, Salvatore Anzalone, Koushik Maharatna, Mohamed Chetouani, Filippo Muratori, David Cohen
BACKGROUND: To meet the required hours of intensive intervention for treating children with autism spectrum disorder (ASD), we developed an automated serious gaming platform (11 games) to deliver intervention at home (GOLIAH) by mapping the imitation and joint attention (JA) subset of age-adapted stimuli from the Early Start Denver Model (ESDM) intervention. Here, we report the results of a 6-month matched controlled exploratory study. METHODS: From two specialized clinics, we included 14 children (age range 5-8 years) with ASD and 10 controls matched for gender, age, sites, and treatment as usual (TAU)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28317138/impact-of-providing-psychiatry-specialty-pharmacist-intervention-on-reducing-drug-related-problems-among-children-with-autism-spectrum-disorder-related-to-disruptive-behavioural-symptoms-a-prospective-randomized-open-label-study
#3
R Wongpakaran, T Suansanae, T Tan-Khum, C Kraivichian, R Ongarjsakulman, C Suthisisang
WHAT IS KNOWN AND OBJECTIVES: Psychopharmacologic therapy has so far focused on ameliorating disruptive behaviours to improve patient's function and quality of life. Due to the complicated neurobiological aetiology of autism spectrum disorder (ASD), a traditional pharmacist intervention may be insufficient to initiate the optimal care for this vulnerable population. We evaluate the impact of providing specialty psychiatry (PS) pharmacist intervention in identifying and resolving drug-related problems (DRPs) among children with ASD associated with disruptive behaviours...
March 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28292223/mechanism-of-action-for-obtaining-job-offers-with-virtual-reality-job-interview-training
#4
Matthew J Smith, Justin D Smith, Michael F Fleming, Neil Jordan, C Hendricks Brown, Laura Humm, Dale Olsen, Morris D Bell
OBJECTIVE: Four randomized controlled trials revealed that virtual-reality job interview training (VR-JIT) improved interviewing skills and the odds of obtaining a job offer among trainees with severe mental illness or autism spectrum disorder. This study assessed whether postintervention interviewing skills mediated the relationship between completion of virtual interviews and receiving job offers by six-month follow-up. METHODS: VR-JIT trainees (N=79) completed pre- and posttest mock interviews and a brief survey approximately six months later to assess whether they received a job offer...
March 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28291262/effects-of-bumetanide-on-neurobehavioral-function-in-children-and-adolescents-with-autism-spectrum-disorders
#5
E Lemonnier, N Villeneuve, S Sonie, S Serret, A Rosier, M Roue, P Brosset, M Viellard, D Bernoux, S Rondeau, S Thummler, D Ravel, Y Ben-Ari
In animal models of autism spectrum disorder (ASD), the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl(-))i levels, enhances GABAergic inhibition and attenuates electrical and behavioral symptoms of ASD. In an earlier phase 2 trial; bumetanide reduced the severity of ASD in children and adolescents (3-11 years old). Here we report the results of a multicenter phase 2B study primarily to assess dose/response and safety effects of bumetanide. Efficacy outcome measures included the Childhood Autism Rating Scale (CARS), the Social Responsive Scale (SRS) and the Clinical Global Impressions (CGI) Improvement scale (CGI-I)...
March 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28276079/a-randomized-controlled-trial-to-examine-the-effects-of-the-tackling-teenage-psychosexual-training-program-for-adolescents-with-autism-spectrum-disorder
#6
Kirsten Visser, Kirstin Greaves-Lord, Nouchka T Tick, Frank C Verhulst, Athanasios Maras, Esther J M van der Vegt
BACKGROUND: Previous research underscores the importance of psychosexual guidance for adolescents with autism spectrum disorder (ASD). Such guidance is provided in the Tackling Teenage Training (TTT) program, in which adolescents with ASD receive psycho-education and practice communicative skills regarding topics related to puberty, sexuality, and intimate relationships. This randomized controlled trial investigated the effects of the TTT program on (a) cognitive outcomes (i.e. psychosexual knowledge, and insight in interpersonal boundaries) and (b) behavioral outcomes (i...
March 9, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28275895/-emotiplay-a-serious-game-for-learning-about-emotions-in-children-with-autism-results-of-a-cross-cultural-evaluation
#7
S Fridenson-Hayo, S Berggren, A Lassalle, S Tal, D Pigat, N Meir-Goren, H O'Reilly, S Ben-Zur, S Bölte, S Baron-Cohen, O Golan
Children with autism spectrum conditions (ASC) experience difficulties recognizing others' emotions and mental states. It has been shown that serious games (SG) can produce simplified versions of the socio-emotional world. The current study performed a cross-cultural evaluation (in the UK, Israel and Sweden) of Emotiplay's SG, a system aimed to teach emotion recognition (ER) to children with ASC in an entertaining, and intrinsically motivating way. Participants were 6-9 year olds with high functioning ASC who used the SG for 8-12 weeks...
March 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28273822/therapeutic-horseback-riding-crossover-effects-of-attachment-behaviors-with-family-pets-in-a-sample-of-children-with-autism-spectrum-disorder
#8
Jessie D Petty, Zhaoxing Pan, Briar Dechant, Robin L Gabriels
The unique needs of individuals with autism spectrum disorder (ASD) have implications for animal welfare. This nested pilot study examined the effects of a randomized trial of 10-week therapeutic horseback riding (THR) intervention versus a no-horse barn activity (BA) control group on children's behaviors with family pets. Sixty-seven (THR n = 31; BA n = 36) participants with ASD (ages 6-16 years) with one or more family pet, were enrolled from a larger trial (n = 116) following their randomization to intervention groups, stratified by nonverbal intellectual ability...
March 3, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28266806/a-pilot-study-of-serotonergic-modulation-after-long-term-administration-of-oxytocin-in-autism-spectrum-disorder
#9
Tetsu Hirosawa, Mitsuru Kikuchi, Yasuomi Ouchi, Tetsuya Takahashi, Yuko Yoshimura, Hirotaka Kosaka, Naoki Furutani, Hirotoshi Hiraishi, Mina Fukai, Masamichi Yokokura, Etsuji Yoshikawa, Tomoyasu Bunai, Yoshio Minabe
Oxytocin (OT) and the serotonergic system putatively play important roles in autism spectrum disorder (ASD) etiology and symptoms, but no direct neurobiological evidence exists for long-term OT administration effects on the brain's serotonergic system. This pilot study examined 10 male participants with ASD who were administered OT intranasally for 8-10 weeks in an open-label, single-arm, nonrandomized, and uncontrolled manner. Positron emission tomography (PET) with a radiotracer ((11) C)-3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile ((11) C-DASB) was used before and after OT treatment...
March 7, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28261045/a-statistical-method-to-distinguish-functional-brain-networks
#10
André Fujita, Maciel C Vidal, Daniel Y Takahashi
One major problem in neuroscience is the comparison of functional brain networks of different populations, e.g., distinguishing the networks of controls and patients. Traditional algorithms are based on search for isomorphism between networks, assuming that they are deterministic. However, biological networks present randomness that cannot be well modeled by those algorithms. For instance, functional brain networks of distinct subjects of the same population can be different due to individual characteristics...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28256072/perceived-social-support-in-adults-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#11
Sonia Alvarez-Fernandez, Hallie R Brown, Yihong Zhao, Jessica A Raithel, Somer L Bishop, Sarah B Kern, Catherine Lord, Eva Petkova, Adriana Di Martino
Perceived social support (PSS) has been related to physical and mental well-being in typically developing individuals, but systematic characterizations of PSS in autism spectrum disorder (ASD) are limited. We compared self-report ratings of the multidimensional scale of PSS (MSPSS) among age- and IQ-matched groups of adults (18-58 years) with cognitively high-functioning ASD (N = 41), or attention-deficit/hyperactivity disorder (ADHD; N = 69), and neurotypical controls (NC; N = 69). Accompanying group comparisons, we used machine learning random forest (RF) analyses to explore predictors among a range of psychopathological and socio-emotional variables...
March 3, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28246025/pediatricians-comfort-level-in-caring-for-children-with-special-health-care-needs
#12
Megumi J Okumura, Heather Knauer, Kris Calvin, John I Takayama
BACKGROUND: Few studies have investigated pediatrician attitudes about providing primary medical care for children with special health care needs (CSHCN). OBJECTIVE: To determine pediatrician perspectives on their comfort level in providing care, and on where the medical home should be for children with chronic medical and developmental conditions. METHODS: Survey of pediatricians in California in 2014. Pediatricians were randomized to receive surveys featuring either a case of a child with a chronic medical (neurofibromatosis) or a developmental condition (autism)...
February 25, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28239517/cortical-interactions-during-the-resolution-of-information-processing-demands-in-autism-spectrum-disorders
#13
Kristina Denisova, Guihu Zhao, Zhishun Wang, Suzanne Goh, Yuankai Huo, Bradley S Peterson
INTRODUCTION: Our flexible and adaptive interactions with the environment are guided by our individual representation of the physical world, estimated through sensation and evaluation of available information against prior knowledge. When linking sensory evidence with higher-level expectations for action, the central nervous system (CNS) in typically developing (TD) individuals relies in part on distributed and interacting cortical regions to communicate neuronal signals flexibly across the brain...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28217829/vitamin-d-and-autism-what-s-new
#14
REVIEW
John Jacob Cannell
An increasing amount of evidence points to the possibility that gestational and early childhood vitamin D deficiency [25(OH)D < 40 ng/ml] cause some cases of autism. Vitamin D is metabolized into a seco-steroid hormone that regulates about 3% of the 26,000 genes in the coding human genome. It is also a neurosteroid that is active in brain development, having effects on cellular proliferation, differentiation, calcium signaling, neurotrophic and neuroprotective actions; it also appears to have an effect on neurotransmission and synaptic plasticity...
February 20, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28209607/parenting-for-autism-language-and-communication-evaluation-study-palaces-protocol-for-a-pilot-randomised-controlled-trial
#15
Margiad Elen Williams, Richard Hastings, Joanna Mary Charles, Sue Evans, Judy Hutchings
INTRODUCTION: Children with autistic spectrum disorder (ASD) often have associated behavioural difficulties that can present a challenge for parents and parenting. There are several effective social learning theory-based parenting programmes for dealing with behavioural difficulties, including the Incredible Years (IY) parent programmes. However, these programmes typically do not specifically target parents of children with ASD. Recently, a new addition to the IY suite of programmes known as the IY Autistic Spectrum and Language Delays (IY-ASLD) parent programme was developed...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28194195/effect-of-mobile-parenting-skills-education-on-anxiety-of-the-mothers-with-autistic-children
#16
Zahra Hajiabolhasani-Nargani, Mostafa Najafi, Tayebeh Mehrabi
BACKGROUND: The parents of autistic children suffer from anxiety and tension. Unawareness of parenting skills required for autistic children (parenting) doubles their anxiety. Researchers have recently considered research on mobile education, especially mobile text messages. The present study aimed to investigate the effect of mobile parenting skills education on the anxiety of mothers with autistic children. MATERIALS AND METHODS: This is a clinical trial conducted on 64 mothers of children suffering from autism who had a medical file...
November 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28193532/age-dependent-atypicalities-in-body-and-face-sensitive-activation-of-the-eba-and-ffa-in-individuals-with-asd
#17
Yuko Okamoto, Hirotaka Kosaka, Ryo Kitada, Ayumi Seki, Hiroki C Tanabe, Masamichi J Hayashi, Takanori Kochiyama, Daisuke N Saito, Hisakazu T Yanaka, Toshio Munesue, Makoto Ishitobi, Masao Omori, Yuji Wada, Hidehiko Okazawa, Tatsuya Koeda, Norihiro Sadato
Individuals with autism spectrum disorder (ASD) have difficuly in recognizing bodies and faces, which are more pronounced in children than adults. If such difficulties originate from dysfunction of the extrastriate body area (EBA) and the fusiform face area (FFA), activation in these regions might be more atypical in children than in adults. We preformed functional magnetic resonance imaging while children and adults with ASD and age-matched typically developed (TD) individuals observed face, body, car, and scene...
February 11, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28168677/examining-the-efficacy-of-a-family-peer-advocate-model-for-black-and-hispanic-caregivers-of-children-with-autism-spectrum-disorder
#18
J M Jamison, E Fourie, P M Siper, M P Trelles, Julia George-Jones, A Buxbaum Grice, J Krata, E Holl, J Shaoul, B Hernandez, L Mitchell, M M McKay, J D Buxbaum, Alexander Kolevzon
Autism spectrum disorder (ASD) affects individuals across all racial and ethnic groups, yet rates of diagnosis are disproportionately higher for Black and Hispanic children. Caregivers of children with ASD experience significant stressors, which have been associated with parental strain, inadequate utilization of mental health services and lower quality of life. The family peer advocate (FPA) model has been utilized across service delivery systems to provide family-to-family support, facilitate engagement, and increase access to care...
February 6, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28130983/efficacy-of-group-social-skills-interventions-for-youth-with-autism-spectrum-disorder-a-systematic-review-and-meta-analysis
#19
REVIEW
Jacquelyn A Gates, Erin Kang, Matthew D Lerner
Group-based social skills interventions (GSSIs) are widely used for treating social competence among youth with autism spectrum disorder (ASD), but their efficacy is unclear. Previous meta-analysis of the literature on well-designed trials of GSSIs is limited in size and scope, collapsing across highly heterogeneous sources (parents; youths; teachers; observers; behavioral tasks). The current meta-analysis of randomized control trials (RCTs) was conducted to ascertain overall effectiveness of GSSIs and differences by reporting sources...
March 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28111607/psychosocial-and-computer-assisted-intervention-for-college-students-with-autism-spectrum-disorder-preliminary-support-for-feasibility
#20
Susan W White, John A Richey, Denis Gracanin, Marika Coffman, Rebecca Elias, Stephen LaConte, Thomas H Ollendick
The number of young adults with Autism Spectrum Disorders (ASD) enrolled in higher education institutions has steadily increased over the last decade. Despite this, there has been little research on how to most effectively support this growing population. The current study presents data from a pilot trial of two novel intervention programs developed for college students with ASD. In this small randomized controlled trial, college students with ASD (n = 8) were assigned to one of two new programs - either an intervention based on a virtual reality-Brain-Computer Interface for ASD (BCI-ASD) or a psychosocial intervention, the College and Living Success (CLS) program...
September 2016: Education and Training in Autism and Developmental Disabilities
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