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https://www.readbyqxmd.com/read/29147630/sulforaphane-from-broccoli-reduces-symptoms-of-autism-a-follow-up-case-series-from-a-randomized-double-blind-study
#1
Rhoda Lynch, Eileen L Diggins, Susan L Connors, Andrew W Zimmerman, Kanwaljit Singh, Hua Liu, Paul Talalay, Jed W Fahey
Introduction: Autism spectrum disorder (ASD) affects 1 in 68 children, is characterized by impaired social interaction and communication as well as restricted or repetitive behaviors, and varies widely with respect to its causes and presentations. There are no validated pharmacologic treatments for the core symptoms of ASD. The social, medical, and economic burdens of ASD on families and caregivers are profound. We recently showed in a small clinical trial that sulforaphane (SF) from broccoli sprouts could significantly reduce the behavioral symptoms of ASD...
2017: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29112459/atomoxetine-parent-training-and-their-effects-on-sleep-in-youth-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#2
Jill A Hollway, Marrisa Mendoza-Burcham, Rebecca Andridge, Michael G Aman, Benjamin Handen, L Eugene Arnold, Luc Lecavalier, Craig Williams, Laura Silverman, Tristram Smith
OBJECTIVE: Sleep disturbance is often a problem for children with either autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). Psychostimulant medications used to treat ADHD symptoms can exacerbate this problem. For children with ASD and ADHD, atomoxetine (ATX) is a viable alternative to psychostimulants. We investigated the effects of ATX and a manualized parent training (PT) program targeting noncompliance, on the sleep quality of children with ASD and ADHD...
November 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29096777/efficacy-and-safety-of-pediatric-prolonged-release-melatonin-for-insomnia-in-children-with-autism-spectrum-disorder
#3
Paul Gringras, Tali Nir, John Breddy, Anat Frydman-Marom, Robert L Findling
OBJECTIVE: To assess the efficacy and safety of novel pediatric-appropriate, prolonged-release melatonin minitablets (PedPRM) versus placebo for insomnia in children and adolescents with autism spectrum disorder (ASD), with or without attention-deficit/hyperactivity disorder (ADHD) comorbidity, and neurogenetic disorders (NGD). METHOD: A total of 125 children and adolescents (2-17.5 years of age; 96.8% ASD, 3.2% Smith-Magenis syndrome [SMS]) whose sleep failed to improve on behavioral intervention alone were randomized (1:1 ratio), double-blind, to receive PedPRM (2 mg escalated to 5 mg) or placebo for 13 weeks...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29071983/-a-preliminary-study-on-effect-of-transcutaneous-electrical-acupoint-stimulation-for-children-with-autism
#4
Ji-Shui Zhang, Xiu-Ting Zhang, Li-Ping Zou, Rong Zhang, Song-Ping Han, Ji-Sheng Han
OBJECTIVE: To investigate the clinical efficacy of transcutaneous electrical acupoint stimulation (TEAS) in treating children with autism spectrum disorders. METHODS: Forty-one autistic children receiving rehabilitation training were randomized into TEAS (n=21) and control (n=20) groups. The control group only received rehabilitation training. The TEAS group received both rehabilitation training and TEAS treatment[2 Hz/15 Hz alternating frequencies through two pairs of skin electrodes placed at Hegu (LI 4)-Neiguan (PC 6) on unilateral side, and Zusanli (ST 36)-Sanyinjiao (SP 6) on the contralateral side]...
June 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29051774/effectiveness-of-the-boost-a%C3%A2-online-transition-planning-program-for-adolescents-on-the-autism-spectrum-a-quasi-randomized-controlled-trial
#5
Megan Hatfield, Marita Falkmer, Torbjorn Falkmer, Marina Ciccarelli
BACKGROUND: The majority of existing transition planning programs are focused on people with a disability in general and may not meet the specific need of adolescents on the autism spectrum. In addition, these interventions focus on specific skills (e.g. job readiness or self-determination) rather than the overall transition planning process and there are methodological limitations to many of the studies determining their effectiveness. The Better OutcOmes & Successful Transitions for Autism (BOOST-A™) is an online program that supports adolescents on the autism spectrum to prepare for leaving school...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/29048234/parent-education-for-young-children-with-autism-and-disruptive-behavior-response-to-active-control-treatment
#6
Jessica Bradshaw, Karen Bearss, Courtney McCracken, Tristram Smith, Cynthia Johnson, Luc Lecavalier, Naomi Swiezy, Lawrence Scahill
This study examines parent and child characteristics in young children with autism spectrum disorder and disruptive behavior who showed a positive response to a parent education program in a randomized clinical trial of parent training. Children with autism spectrum disorder (N = 180) were randomized to parent training (PT) or parent education program (PEP) for 6 months. Using the Clinical Global Impression-Improvement scale, masked independent evaluators rated positive response in 68.5% of children in PT compared to 39...
October 19, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29045959/-prevalence-of-autism-spectrum-disorders-in-children-aged-0-6-years-in-china-a-meta-analysis
#7
H F Shi, J X Zhang, R Zhang, X L Wang
OBJECTIVE: To estimate the prevalence and trend of autism spectrum disorders (ASD) in children aged 0-6 years in China. METHODS: Systematic literature searches were conducted in PubMed, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wanfang and Weipu Database (VIP ), and the literatures published before February 25, 2017 were selected according to the same criteria. Prevalence Data of three periods were abstracted, then pooled using random effect model...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29042783/supplementation-of-omega-3-fatty-acids-may-improve-hyperactivity-lethargy-and-stereotypy-in-children-with-autism-spectrum-disorders-a-meta-analysis-of-randomized-controlled-trials
#8
Yu-Shian Cheng, Ping-Tao Tseng, Yen-Wen Chen, Brendon Stubbs, Wei-Chieh Yang, Tien-Yu Chen, Ching-Kuan Wu, Pao-Yen Lin
AIM: Deficiency of omega 3 fatty acids may be linked to autism spectrum disorder (ASD). Evidence about the potential therapeutic effects of supplementation of omega 3 fatty acids is lacking in ASD patients. METHODS: We searched major electronic databases from inception to June 21, 2017, for randomized clinical trials, which compared treatment outcomes between supplementation of omega 3 fatty acids and placebo in patients with ASD. An exploratory random-effects meta-analysis of the included studies was undertaken...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29027815/l-carnosine-as-an-adjunctive-therapy-to-risperidone-in-children-with-autistic-disorder-a-randomized-double-blind-placebo-controlled-trial
#9
Reihaneh Hajizadeh-Zaker, Alireza Ghajar, Bita Mesgarpour, Mohsen Afarideh, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
OBJECTIVES: This study aimed at investigating the efficacy and tolerability of l-carnosine as an add-on to risperidone in the management of children with autism. METHODS: This was a 10-week, randomized, double-blind, placebo-controlled study. Seventy drug-free children aged 4-12 years old with a diagnosis of autism spectrum disorder (ASD), according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (DSM-5) who had an Aberrant Behavior Checklist-Community (ABC-C) scale irritability subscale score of ≥12, entered the study...
October 13, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29026508/the-association-between-maternal-use-of-folic-acid-supplements-during-pregnancy-and-risk-of-autism-spectrum-disorders-in-children-a-meta-analysis
#10
Meiyun Wang, Kaiqin Li, Dongmei Zhao, Ling Li
Previous reviews have been conducted to evaluate the association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders (ASD) in children, with no definitive conclusion. We therefore conducted a more comprehensive meta-analysis to reassess the relationship between folic acid and the risk of ASD. The electronic databases PubMed, Web of Knowledge, and Wanfang Data were carefully searched to find eligible studies as recent as March 2017. A random effects model was used to combine the relative risk (RR) with 95% confidence intervals (CI)...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29022125/parent-stress-in-a-randomized-clinical-trial-of-atomoxetine-and-parent-training-for-children-with-autism-spectrum-disorder
#11
Luc Lecavalier, Xueliang Pan, Tristram Smith, Benjamin L Handen, L Eugene Arnold, Laura Silverman, Rameshwari V Tumuluru, Jill Hollway, Michael G Aman
We previously reported a 2 × 2 randomized clinical trial of atomoxetine (ATX) and parent training (PT) for attention deficit hyperactivity disorder (ADHD) symptoms and behavioral noncompliance in 128 children with autism spectrum disorder, ages 5-14 years. Children were randomized to one of four conditions: ATX alone, placebo alone, ATX + PT, or PT + placebo. Both ATX and PT improved some indices of ADHD and behavioral compliance. In this report, we describe parent stress over time and across conditions...
October 11, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29020136/traffic-related-air-pollution-and-autism-spectrum-disorder-a-population-based-nested-case-control-study-in-israel
#12
Raanan Raz, Hagai Levine, Ofir Pinto, David M Broday, Yuval, Marc G Weisskopf
Accumulating evidence suggests that perinatal air pollutant exposures are associated with increased risk of autism spectrum disorder (ASD), but evidence outside the US for traffic pollutants is inconclusive. We assessed the association between NO2, a traffic pollution tracer, and risk of ASD. We conducted a nested case-control study among the entire population of children born 2005-2009 in the central coastal area of Israel. Cases were identified through the National Insurance Institute of Israel (n = 2,098)...
August 17, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28994903/antidepressant-exposure-during-pregnancy-and-risk-of-autism-in-the-offspring-1-meta-review-of-meta-analyses
#13
Chittaranjan Andrade
There are no randomized controlled trials of antidepressant drugs to treat depression, or to prevent relapse into depression, during pregnancy; therefore, the safety of antidepressant drug exposure during pregnancy is based on evidence from case-control or cohort studies. Many of these observational studies, during the past decade, examined the risk of autism spectrum disorder (ASD) in exposed offspring. Different studies using different methods and examining different periods of antidepressant exposure before and during pregnancy obtained different results...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28988339/teaching-parents-behavioral-strategies-for-autism-spectrum-disorder-asd-effects-on-stress-strain-and-competence
#14
Suzannah Iadarola, Lynne Levato, Bryan Harrison, Tristram Smith, Luc Lecavalier, Cynthia Johnson, Naomi Swiezy, Karen Bearss, Lawrence Scahill
We report on parent outcomes from a randomized clinical trial of parent training (PT) versus psychoeducation (PEP) in 180 children with autism spectrum disorder (ASD) and disruptive behavior. We compare the impact of PT and PEP on parent outcomes: Parenting Stress Index (PSI), Parent Sense of Competence (PSOC), and Caregiver Strain Questionnaire (CGSQ). Mixed-effects linear models evaluated differences at weeks 12 and 24, controlling for baseline scores. Parents in PT reported greater improvement than PEP on the PSOC (ES = 0...
October 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28976309/simple-transparent-and-flexible-automated-quality-assessment-procedures-for-ambulatory-electrodermal-activity-data
#15
Ian R Kleckner, Rebecca M Jones, Oliver Wilder-Smith, Jolie B Wormwood, Murat Akcakaya, Karen S Quigley, Catherine Lord, Matthew S Goodwin
OBJECTIVE: Electrodermal activity (EDA) is a non-invasive measure of sympathetic activation often used to study emotions, decision-making, and health. The use of "ambulatory" EDA in everyday life presents novel challenges-frequent artifacts and long recordings-with inconsistent methods available for efficiently and accurately assessing data quality. We developed and validated a simple, transparent, flexible, and automated quality assessment procedure for ambulatory EDA data. METHODS: Twenty individuals with autism (5 females, 5-13 years) provided a combined 181 hours of EDA data in their home using the Affectiva Q Sensor across 8 weeks...
October 2, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28965590/the-association-between-mercury-levels-and-autism-spectrum-disorders-a-systematic-review-and-meta-analysis
#16
Tina Jafari, Noushin Rostampour, Aziz A Fallah, Afshin Hesami
BACKGROUND & AIMS: The relationship between mercury and autism spectrum disorders (ASD) has always been a topic of controversy among researchers. This study aimed to assess the relationship between ASD and mercury levels in hair, urine, blood, red blood cells (RBC), and brain through a meta-analysis. METHODS: A systematic search was performed in several databases including PubMed, ISI Web of Science, Cochrane register of controlled trials, Google Scholar, Scopus, and MagIran until June 2017...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28955254/android-robot-mediated-mock-job-interview-sessions-for-young-adults-with-autism-spectrum-disorder-a-pilot-study
#17
Hirokazu Kumazaki, Zachary Warren, Blythe A Corbett, Yuichiro Yoshikawa, Yoshio Matsumoto, Haruhiro Higashida, Teruko Yuhi, Takashi Ikeda, Hiroshi Ishiguro, Mitsuru Kikuchi
The feasibility and preliminary efficacy of an android robot-mediated mock job interview training in terms of both bolstering self-confidence and reducing biological levels of stress in comparison to a psycho-educational approach human interview was assessed in a randomized study. Young adults (ages 18-25 years) with autism spectrum disorder (ASD) were randomized to participate either in a mock job interview training with our android robot system (n = 7) or a self-paced review of materials about job-interviewing skills (n = 8)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28942807/a-randomized-placebo-controlled-trial-of-metformin-for-the-treatment-of-overweight-induced-by-antipsychotic-medication-in-young-people-with-autism-spectrum-disorder-open-label-extension
#18
Benjamin L Handen, Evdokia Anagnostou, Michael G Aman, Kevin B Sanders, James Chan, Jill A Hollway, Jessica Brian, L Eugene Arnold, Lucia Capano, Craig Williams, Jessica A Hellings, Eric Butter, Deepali Mankad, Rameshwari Tumuluru, Jessica Kettel, Cassandra R Newsom, Naomi Peleg, Dina Odrobina, Sarah McAuliffe-Bellin, Sarah Marler, Taylor Wong, Alexis Wagner, Stasia Hadjiyannakis, Eric A Macklin, Jeremy Veenstra-VanderWeele
OBJECTIVE: A previous study reported on a 16-week placebo-controlled, randomized clinical trial (RCT) of metformin for weight stabilization in 61 children and adolescents 6 to 17 years old with autism spectrum disorder who were prescribed atypical antipsychotics. The present study describes the results of a 16-week open-label extension. METHOD: Fifty-two participants from the acute trial (85%) entered the extension; 22 had been on metformin during the initial RCT and 30 had been on placebo...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28941976/omega-3-and-6-fatty-acid-supplementation-and-sensory-processing-in-toddlers-with-asd-symptomology-born-preterm-a-randomized-controlled-trial
#19
Kelly M Boone, Barbara Gracious, Mark A Klebanoff, Lynette K Rogers, Joseph Rausch, Daniel L Coury, Sarah A Keim
BACKGROUND: Despite advances in the health and long-term survival of infants born preterm, they continue to face developmental challenges including higher risk for autism spectrum disorder (ASD) and atypical sensory processing patterns. AIMS: This secondary analysis aimed to describe sensory profiles and explore effects of combined dietary docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and gamma-linolenic acid (GLA) supplementation on parent-reported sensory processing in toddlers born preterm who were exhibiting ASD symptoms...
September 20, 2017: Early Human Development
https://www.readbyqxmd.com/read/28941259/an-open-label-extension-long-term-study-of-the-safety-and-efficacy-of-aripiprazole-for-irritability-in-children-and-adolescents-with-autistic-disorder-in-japan
#20
Hironobu Ichikawa, Michio Hiratani, Akihiro Yasuhara, Noa Tsujii, Takashi Oshimo, Hiroaki Ono, Yoshihiro Tadori
AIM: The purpose of this study was to evaluate the long-term safety and efficacy of aripiprazole in treating irritability in pediatric patients (6-17 years) with autistic disorder (AD) in Japan. METHODS: In this open-label extension study, patients who had completed a previous randomized, double-blind, placebo-controlled 8-week study were enrolled and were flexibly dosed with aripiprazole (1-15 mg/day) until the new indication of irritability in pediatric autism spectrum disorder was approved in Japan...
September 23, 2017: Psychiatry and Clinical Neurosciences
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