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https://www.readbyqxmd.com/read/28091344/a-comprehensive-systematic-review-and-meta-analysis-of-pharmacological-and-dietary-supplement-interventions-in-paediatric-autism-moderators-of-treatment-response-and-recommendations-for-future-research
#1
A Masi, A Lampit, M M DeMayo, N Glozier, I B Hickie, A J Guastella
BACKGROUND: Autism spectrum disorders (ASDs) are pervasive and multifactorial neurodevelopmental conditions, characterized by impairments in social communication and interaction, and restricted, repetitive patterns of behaviour, interests or activities. Treatment options to ameliorate symptoms of ASDs are limited. Heterogeneity complicates the quest for personalized medicine in this population. Our aim was to investigate if there are baseline characteristics of patients that moderate response or trial design features that impede the identification of efficacious interventions for ASDs...
January 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28077731/%C3%AF-3-fatty-acid-supplementation-does-not-affect-autism-spectrum-disorder-in-children-a-systematic-review-and-meta-analysis
#2
Andrea Horvath, Jan Łukasik, Hania Szajewska
BACKGROUND: Effective treatments for the core symptoms of autism spectrum disorder (ASD) are still lacking. OBJECTIVE: We aimed to update the data on the effectiveness of ω-3 (n-3) fatty acid (FA) supplementation as a treatment for ASD. METHODS: The Cochrane Library, MEDLINE, and EMBASE databases were systematically searched up until August 2016, with no language restrictions for randomized controlled trials (RCTs) comparing ω-3 FA supplementation with placebo or with no supplementation...
January 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28074355/evaluation-of-visual-pedagogy-in-dental-check-ups-and-preventive-practices-among-6-12-year-old-children-with-autism
#3
Firoozeh Nilchian, Fereshteh Shakibaei, Zeinab Taghi Jarah
This study was aimed to evaluate the impact of visual pedagogy in dental check-ups and preventive practices among children with autism aged 6-12. In this randomized double-blind clinical trial, the cooperation of 40 children with autism age 6-12. The selected children were equally divided into two groups of case and control (n = 20). The obtained data were analyzed by statistical tests, including Chi square and independent t test. The results of Cochran showed a significant increase in children's cooperation with regard to fluoride therapy in the case group by repeating the visit and training sessions (p ≤ 0...
January 10, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28070786/training-parents-of-youth-with-autism-spectrum-disorder-to-advocate-for-adult-disability-services-results-from-a-pilot-randomized-controlled-trial
#4
Julie Lounds Taylor, Robert M Hodapp, Meghan M Burke, Sydney N Waitz-Kudla, Carol Rabideau
This study presents findings from a pilot randomized controlled trial, testing a 12-week intervention to train parents of youth with autism spectrum disorder (ASD) to advocate for adult disability services-the Volunteer Advocacy Program-Transition (VAP-T). Participants included 41 parents of youth with ASD within 2 years of high school exit, randomly assigned to a treatment (N = 20) or wait-list control (N = 21) group. Outcomes, collected before and after the intervention, included parental knowledge about adult services, advocacy skills-comfort, and empowerment...
January 9, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28025692/age-related-differences-in-inhibitory-control-and-memory-updating-in-boys-with-asperger-syndrome
#5
Elisabeth M Weiss, Bianca Gschaidbauer, Liane Kaufmann, Andreas Fink, Günter Schulter, Erich Mittenecker, Ilona Papousek
Deficits in specific executive domains are highly prevalent in autism spectrum disorder; however, age-related improvements in executive functions (reflecting prefrontal maturational changes) have been reported even in individuals diagnosed with autism. The current study examined two components of cognitive flexibility (inhibition of prepotent responses and memory monitoring/updating) by using a random-motor-generation task (MPT) in a group of 23 boys with Asperger syndrome (AS) and 23 matched healthy controls...
December 26, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28012300/long-term-outcomes-and-predictors-of-internet-delivered-cognitive-behavioral-therapy-for-childhood-anxiety-disorders
#6
Sarah Vigerland, Eva Serlachius, Ulrika Thulin, Gerhard Andersson, Jan-Olov Larsson, Brjánn Ljótsson
OBJECTIVE: This study investigated the long-term outcomes of internet-delivered cognitive behavior therapy (ICBT) for children with anxiety disorders, and potential pre-treatment predictors of treatment outcome. METHOD: The sample included eighty-four children (8-12 years old) with anxiety disorders, from both a treatment group and a waitlist control (after participants had crossed over to treatment) of a previous randomized controlled study. Participants were assessed at post-treatment and three- and twelve-months after treatment using a semi-structured interview and parent ratings...
December 14, 2016: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28004215/aripiprazole-in-the-treatment-of-irritability-in-children-and-adolescents-with-autism-spectrum-disorder-in-japan-a-randomized-double-blind-placebo-controlled-study
#7
Hironobu Ichikawa, Katsunaka Mikami, Takashi Okada, Yushiro Yamashita, Yuko Ishizaki, Akemi Tomoda, Hiroaki Ono, Chiharu Usuki, Yoshihiro Tadori
We evaluated the efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents (6-17 years) with autism spectrum disorder (ASD) in a randomized, double-blind, placebo-controlled 8-week study in Japan. Patients received flexibly dosed aripiprazole (1-15 mg/day) or placebo. Ninety-two patients were randomized to placebo (n = 45) or aripiprazole (n = 47). Aripiprazole produced a significant improvement in the mean parent/caregiver-rated Aberrant Behavior Checklist Japanese Version irritability subscale score relative to placebo from week 3 through week 8...
December 21, 2016: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28002438/development-of-a-machine-learning-algorithm-for-the-surveillance-of-autism-spectrum-disorder
#8
Matthew J Maenner, Marshalyn Yeargin-Allsopp, Kim Van Naarden Braun, Deborah L Christensen, Laura A Schieve
The Autism and Developmental Disabilities Monitoring (ADDM) Network conducts population-based surveillance of autism spectrum disorder (ASD) among 8-year old children in multiple US sites. To classify ASD, trained clinicians review developmental evaluations collected from multiple health and education sources to determine whether the child meets the ASD surveillance case criteria. The number of evaluations collected has dramatically increased since the year 2000, challenging the resources and timeliness of the surveillance system...
2016: PloS One
https://www.readbyqxmd.com/read/28001493/enhancing-conflict-negotiation-strategies-of-adolescents-with-autism-spectrum-disorder-using-video-modeling
#9
M Hochhauser, P L Weiss, E Gal
Adolescents with autism spectrum disorder (ASD) have particular difficulty in negotiating conflict. A randomized control trial (RCT) was carried out to determine whether the negotiation strategies of adolescents with ASD would be enhanced via a 6 week intervention based on a video modeling application. Adolescents with ASD, aged 12-18 years, were randomly divided into an intervention group (n = 36) and a non-treatment control group (n = 25). Participants' negotiating strategies prior to, and following the intervention were measured using the Five Factor Negotiation Scale (Nakkula & Nikitopoulos, 1999) and the ConflicTalk questionnaire (Kimsey & Fuller, 2003)...
December 21, 2016: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/27999683/a-preliminary-investigation-of-a-specialized-music-therapy-model-for-children-with-disabilities-delivered-in-a-classroom-setting
#10
Jenna Mendelson, Yasmine White, Laura Hans, Richard Adebari, Lorrie Schmid, Jan Riggsbee, Ali Goldsmith, Burcu Ozler, Kristen Buehne, Sarah Jones, Jennifer Shapleton, Geraldine Dawson
Music therapy is gaining popularity as an intervention strategy for children with developmental disabilities, including autism spectrum disorder (ASD). This study was a pilot investigation of a classroom-based music-based intervention, Voices Together®, for improving communication skills in children with ASD and children with intellectual disabilities. Four local public elementary school special education classrooms, serving 5 children with a classification of autistic disorder and 32 children with intellectual disability without autism, were randomly selected to receive one of two levels of exposure to Voices Together music therapy: "long-term" (15 weeks beginning in January 2015 (Time 1), n = 14) or "short-term" (7 weeks beginning 7 weeks later in February (Time 2), n = 17)...
2016: Autism Research and Treatment
https://www.readbyqxmd.com/read/27990746/parents-opinions-about-an-intervention-to-manage-repetitive-behaviours-in-young-children-with-autism-spectrum-disorder-a-qualitative-study
#11
Anna R Hodgson, Victoria Grahame, Deborah Garland, Fiona Gaultier, Jan Lecouturier, Ann Le Couteur
BACKGROUND: Early intervention for autism spectrum disorder (ASD) tends to focus on enhancing social communication skills. We report data collected via focus group discussions as part of a feasibility and acceptability pilot randomized controlled trial (RCT) about a new parent group intervention to manage restricted and repetitive behaviours (RRB) in young children with ASD. METHODS: The focus groups were led by two independent facilitators and followed a semi-structured topic guide with the aim of considering three key topics: experiences of participating in a RCT, opinions about the intervention and the impact of the intervention on the participants, their children and the family...
December 19, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/27966784/hybrid-implementation-model-of-community-partnered-early-intervention-for-toddlers-with-autism-a-randomized-trial
#12
Stephanie Y Shire, Ya-Chih Chang, Wendy Shih, Suzanne Bracaglia, Maria Kodjoe, Connie Kasari
BACKGROUND: Interventions found to be effective in research settings are often not as effective when implemented in community settings. Considering children with autism, studies have rarely examined the efficacy of laboratory-tested interventions on child outcomes in community settings using randomized controlled designs. METHODS: One hundred and thirteen children with autism enrolled in public early intervention classrooms in low resource neighborhoods were randomized to Joint Attention, Symbolic Play, Engagement, and Regulation (JASPER) intervention or treatment as usual waitlist for 10 weeks with 1-month follow-up...
December 14, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27940149/close-genetic-relationships-between-a-spousal-pair-with-autism-affected-children-and-high-minor-allele-content-in-cases-in-autism-associated-snps
#13
Zuobin Zhu, Xitong Lu, Dejian Yuan, Shi Huang
Parents of children affected with autism spectrum disorders (ASD) often have mild forms of autistic-like characteristics. Past studies have focused on searching for individual genetic risk loci of ASD. Here we studied the overall properties of the genomes of ASD trios by using previously published genome-wide data for common SNPs. The pairwise genetic distance (PGD) between a spousal pair with ASD-affected children was found smaller than that of a random pair selected among the spouses in the ASD trios, and spousal relatedness correlated with severe forms of ASD...
January 2017: Genomics
https://www.readbyqxmd.com/read/27939561/phakic-intraocular-collamer-lens-visian-icl-implantation-for-correction-of-myopia-in-spectacle-aversive-special-needs-children
#14
Lawrence Tychsen, Nicholas Faron, James Hoekel
PURPOSE: A subset of children with high anisometropia or isoametropia and neurobehavioral disorders have chronic difficulties with spectacle or contact lens wear. We report the results of refractive surgery in a series of these children treated using bilateral or unilateral intraocular collamer lens (Visian ICL) implantation for moderate to high myopia. DESIGN: Prospective non-randomized cohort study. METHODS: Clinical course and outcome data were collated prospectively for 40 implanted eyes in 23 children (mean age 10...
December 6, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27929319/effects-of-psychomotor-intervention-program-on-students-with-autism-spectrum-disorder
#15
Sayed ElGarhy, Ting Liu
The purpose of this study was to examine the effects of a psychomotor intervention program (PIP) on body awareness and psychomotor concepts for students with autism spectrum disorder (ASD). Twenty-eight students (23 boys and 5 girls) with ASD participated in this study. Fourteen students with ASD were randomly assigned to the experimental group (12 boys and 2 girls; mean age of 5.48 years), and 14 students were assigned to the control group (11 boys and 3 girls; mean age of 5.2 years). Students in the experimental group were trained with the PIP activities (targeting body awareness, body concepts, space concepts, and time concepts) three times a week for 10 weeks...
December 2016: School Psychology Quarterly
https://www.readbyqxmd.com/read/27918841/community-effectiveness-rct-of-a-comprehensive-psychosocial-treatment-for-high-functioning-children-with-asd
#16
Marcus L Thomeer, Christopher Lopata, James P Donnelly, Adam Booth, Andrew Shanahan, Veronica Federiconi, Christin A McDonald, Jonathan D Rodgers
This community effectiveness randomized clinical trial examined the feasibility and effectiveness of a comprehensive psychosocial treatment, summerMAX, when implemented by a community agency. Fifty-seven high-functioning children (48 male, 9 female), ages 7-12 years with autism spectrum disorder participated in this study. The 5-week summerMAX treatment included instruction and therapeutic activities targeting social/social-communication skills, interpretation of nonliteral language skills, face-emotion recognition skills, and interest expansion...
December 5, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27917460/moderators-of-parent-training-for-disruptive-behaviors-in-young-children-with-autism-spectrum-disorder
#17
Luc Lecavalier, Tristram Smith, Cynthia Johnson, Karen Bearss, Naomi Swiezy, Michael G Aman, Denis G Sukhodolsky, Yanhong Deng, James Dziura, Lawrence Scahill
We conducted a 6 month, randomized trial of parent training (PT) versus a parent education program (PEP) in 180 young children (158 boys, 22 girls), ages 3-7 years, with autism spectrum disorder (ASD). PT was superior to PEP in decreasing disruptive and noncompliant behaviors. In the current study, we assess moderators of treatment response in this trial. Thirteen clinical and demographic variables were evaluated as potential moderators of three outcome variables: the Aberrant Behavior Checklist-Irritability subscale (ABC-I), Home Situations Questionnaire (HSQ), and Clinical Global Impressions-Improvement Scale (CGI-I)...
December 5, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27893955/using-a-patient-centered-outcome-measure-to-test-methylphenidate-versus-placebo-in-children-with-autism-spectrum-disorder
#18
Lawrence Scahill, Karen Bearss, Rena Sarhangian, Christopher J McDougle, L Eugene Arnold, Michael G Aman, James T McCracken, Elaine Tierney, Scott Gillespie, Valentina Postorino, Benedetto Vitiello
OBJECTIVES: Parent rating scales are commonly used to evaluate change in clinical trials. Despite advantages, these measures may not capture parental impression of the child's most salient problems. We examine the use of parent target problems (PTPs) in a randomized trial of methylphenidate (MPH) in children with autism spectrum disorder and symptoms of attention-deficit/hyperactivity disorder. METHODS: This multisite, 4-week, randomized crossover trial compared three dose levels (low, medium, and high) of MPH with placebo...
November 28, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27884169/study-protocol-implementation-of-a-computer-assisted-intervention-for-autism-in-schools-a-hybrid-type-ii-cluster-randomized-effectiveness-implementation-trial
#19
Melanie Pellecchia, Rinad S Beidas, Steven C Marcus, Jessica Fishman, John R Kimberly, Carolyn C Cannuscio, Erica M Reisinger, Keiran Rump, David S Mandell
BACKGROUND: The number of children diagnosed with autism has rapidly outpaced the capacities of many public school systems to serve them, especially under-resourced, urban school districts. The intensive nature of evidence-based autism interventions, which rely heavily on one-to-one delivery, has caused schools to turn to computer-assisted interventions (CAI). There is little evidence regarding the feasibility, effectiveness, and implementation of CAI in public schools. While CAI has the potential to increase instructional time for students with autism, it may also result in unintended consequences such as reduction in the amount of interpersonal (as opposed to computerized) instruction students receive...
November 25, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27874271/diagnostic-model-generated-by-mri-derived-brain-features-in-toddlers-with-autism-spectrum-disorder
#20
Xiang Xiao, Hui Fang, Jiansheng Wu, ChaoYong Xiao, Ting Xiao, Lu Qian, FengJing Liang, Zhou Xiao, Kang Kang Chu, Xiaoyan Ke
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with core symptoms of atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests, and activities. Although the pathophysiologic mechanism of ASD is unclarified yet, the neuroanatomical features are considered as valuable predictors for discriminating ASD from others. But there has been relatively little scientific study about predictive power of different neuroanatomical features of early age ASD...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
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