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https://www.readbyqxmd.com/read/28942807/a-randomized-placebo-controlled-trial-of-metformin-for-the-treatment-of-overweight-induced-by-antipsychotic-medication-in-young-people-with-autism-spectrum-disorder-open-label-extension
#1
Benjamin L Handen, Evdokia Anagnostou, Michael G Aman, Kevin B Sanders, James Chan, Jill A Hollway, Jessica Brian, L Eugene Arnold, Lucia Capano, Craig Williams, Jessica A Hellings, Eric Butter, Deepali Mankad, Rameshwari Tumuluru, Jessica Kettel, Cassandra R Newsom, Naomi Peleg, Dina Odrobina, Sarah McAuliffe-Bellin, Sarah Marler, Taylor Wong, Alexis Wagner, Stasia Hadjiyannakis, Eric A Macklin, Jeremy Veenstra-VanderWeele
OBJECTIVE: A previous study reported on a 16-week placebo-controlled, randomized clinical trial (RCT) of metformin for weight stabilization in 61 children and adolescents 6 to 17 years old with autism spectrum disorder who were prescribed atypical antipsychotics. The present study describes the results of a 16-week open-label extension. METHOD: Fifty-two participants from the acute trial (85%) entered the extension; 22 had been on metformin during the initial RCT and 30 had been on placebo...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28941976/omega-3-and-6-fatty-acid-supplementation-and-sensory-processing-in-toddlers-with-asd-symptomology-born-preterm-a-randomized-controlled-trial
#2
Kelly M Boone, Barbara Gracious, Mark A Klebanoff, Lynette K Rogers, Joseph Rausch, Daniel L Coury, Sarah A Keim
BACKGROUND: Despite advances in the health and long-term survival of infants born preterm, they continue to face developmental challenges including higher risk for autism spectrum disorder (ASD) and atypical sensory processing patterns. AIMS: This secondary analysis aimed to describe sensory profiles and explore effects of combined dietary docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and gamma-linolenic acid (GLA) supplementation on parent-reported sensory processing in toddlers born preterm who were exhibiting ASD symptoms...
September 20, 2017: Early Human Development
https://www.readbyqxmd.com/read/28941259/an-open-label-extension-long-term-study-of-the-safety-and-efficacy-of-aripiprazole-for-irritability-in-children-and-adolescents-with-autistic-disorder-in-japan
#3
Hironobu Ichikawa, Michio Hiratani, Akihiro Yasuhara, Noa Tsujii, Takashi Oshimo, Hiroaki Ono, Yoshihiro Tadori
AIMS: The purpose of this study was to evaluate the long-term safety and efficacy of aripiprazole in treating irritability in pediatric patients (6-17 years) with autistic disorder (AD) in Japan. METHODS: In this open-label extension study, patients who completed a previous randomized, double-blind, placebo-controlled 8-week study were enrolled and were flexibly dosed with aripiprazole (1-15 mg/day) until the new indication of irritability in pediatric autism spectrum disorder was approved in Japan...
September 23, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28935269/randomized-trial-of-omega-3-for-autism-spectrum-disorders-effect-on-cell-membrane-composition-and-behavior
#4
Mara Parellada, Cloe Llorente, Rosa Calvo, Silvia Gutierrez, Luisa Lázaro, Montserrat Graell, Maria Guisasola, Maria Luisa Dorado, Leticia Boada, Jose Romo, Elena Dulin, Inmaculada Sanz, Celso Arango, Carmen Moreno
A high ω6/ω3 ratio [fatty acid (FA) index] in the cell membrane has been associated with inadequate brain development. It has started to be used as a biomarker of treatment efficacy in human diseases. The aim of this study was to investigate if omega-3 supplementation improves erythrocyte membrane ω6/ω3, plasma antioxidant status (TAS) and autistic behaviors. A randomized, crossover, placebo-controlled study was designed to investigate the effect of 8 weeks of supplementation with ω3 (962mg/d and 1155mg/d for children and adolescents, respectively)...
September 18, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28934215/tracing-the-temporal-stability-of-autism-spectrum-diagnosis-and-severity-as-measured-by-the-autism-diagnostic-observation-schedule-a-systematic-review-and-meta-analysis
#5
Łucja Bieleninik, Maj-Britt Posserud, Monika Geretsegger, Grace Thompson, Cochavit Elefant, Christian Gold
BACKGROUND: Exploring ways to improve the trajectory and symptoms of autism spectrum disorder is prevalent in research, but less is known about the natural prognosis of autism spectrum disorder and course of symptoms. The objective of this study was to examine the temporal stability of autism spectrum disorder and autism diagnosis, and the longitudinal trajectories of autism core symptom severity. We furthermore sought to identify possible predictors for change. METHODS: We searched PubMed, PsycInfo, EMBASE, Web of Science, Cochrane Library up to October 2015 for prospective cohort studies addressing the autism spectrum disorder/autism diagnostic stability, and prospective studies of intervention effects...
2017: PloS One
https://www.readbyqxmd.com/read/28932904/a-computational-method-using-the-random-walk-with-restart-algorithm-for-identifying-novel-epigenetic-factors
#6
JiaRui Li, Lei Chen, ShaoPeng Wang, YuHang Zhang, XiangYin Kong, Tao Huang, Yu-Dong Cai
Epigenetic regulation has long been recognized as a significant factor in various biological processes, such as development, transcriptional regulation, spermatogenesis, and chromosome stabilization. Epigenetic alterations lead to many human diseases, including cancer, depression, autism, and immune system defects. Although efforts have been made to identify epigenetic regulators, it remains a challenge to systematically uncover all the components of the epigenetic regulation in the genome level using experimental approaches...
September 20, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28929582/the-effectiveness-of-a-psychoeducation-intervention-delivered-via-whatsapp-for-mothers-of-children-with-autism-spectrum-disorder-asd-in-the-kingdom-of-saudi-arabia-a-randomized-controlled-trial
#7
A Hemdi, D Daley
BACKGROUND: Mothers of children with autism spectrum disorder (ASD) report high levels of stress and lower levels of well-being than parents of typically developing children. Current interventions for ASD typically focus on working with the child rather than delivering strategies to help support parents. OBJECTIVE: To evaluate the effectiveness of a psychoeducation intervention developed to support mothers of children with ASD in Saudi Arabia. METHOD: Sixty-two mothers (23-52 years) of children (26-78 months) were recruited to a multisite randomized controlled trials of the intervention...
September 20, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28928448/intact-animacy-perception-during-chase-detection-in-asd
#8
Steven Vanmarcke, Sander van de Cruys, Pieter Moors, Johan Wagemans
We explored the strength of implicit social inferences in adolescents with and without Autism Spectrum Disorder (ASD) using a chasing paradigm in which participants judged the absence/presence of a chase within a display of four seemingly randomly moving dots. While two of these dots always moved randomly, the two others could fulfill the role of being either the chasing (wolf) or chased (sheep) dot. In the chase-present (but not the chase-absent) trials the wolf displayed chasing behavior defined by the degree to which the dot reliably moved towards the sheep (chasing subtlety)...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926975/non-invasive-brain-stimulation-for-children-with-autism-spectrum-disorders-a-short-term-outcome-study
#9
Lázaro Gómez, Belkis Vidal, Carlos Maragoto, Lilia Maria Morales, Sheyla Berrillo, Héctor Vera Cuesta, Margarita Baez, Marlén Denis, Tairí Marín, Yaumara Cabrera, Abel Sánchez, Celia Alarcón, Maribel Selguera, Yaima Llanez, Lucila Dieguez, María Robinson
Non-Invasive Brain Stimulation (NIBS) is a relatively new therapeutic approach that has shown beneficial effects in Autism Spectrum Disorder (ASD). One question to be answered is how enduring its neuromodulatory effect could be. Twenty-four patients with ASD (mean age: 12.2 years) received 20 sessions of NIBS over the left dorsolateral prefrontal cortex (L-DLPFC). They were randomized into two groups with two (G1) or three (G2) clinical evaluations before NIBS. Both groups had a complete follow-up at six months after the intervention, with the aim of determining the short-term outcome using the total score on the Autism Behavior Checklist, Autism Treatment Evaluation Checklist, and the Autism Diagnostic Interview...
September 17, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28924187/the-ipsych2012-case-cohort-sample-new-directions-for-unravelling-genetic-and-environmental-architectures-of-severe-mental-disorders
#10
C B Pedersen, J Bybjerg-Grauholm, M G Pedersen, J Grove, E Agerbo, M Bækvad-Hansen, J B Poulsen, C S Hansen, J J McGrath, T D Als, J I Goldstein, B M Neale, M J Daly, D M Hougaard, O Mors, M Nordentoft, A D Børglum, T Werge, P B Mortensen
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28919764/levetiracetam-is-associated-with-decrease-in-subclinical-epileptiform-discharges-and-improved-cognitive-functions-in-pediatric-patients-with-autism-spectrum-disorder
#11
Minjian Wang, Li Jiang, Xiaoju Tang
OBJECTIVE: Subclinical epileptiform discharges (SEDs) are common in pediatric patients with autism spectrum disorder (ASD), but the effect of antiepileptic drugs on SEDs in ASD remains inconclusive. This physician-blinded, prospective, randomized controlled trial investigated an association between the anticonvulsant drug levetiracetam and SEDs in children with ASD. METHODS: A total of 70 children with ASD (4-6 years) and SEDs identified by electroencephalogram were randomly divided into two equal groups to receive either levetiracetam and educational training (treatment group) or educational training only (control)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28916794/association-among-obesity-overweight-and-autism-spectrum-disorder-a-systematic-review-and-meta-analysis
#12
Zhen Zheng, Li Zhang, Shiping Li, Fengyan Zhao, Yan Wang, Lan Huang, Jinglan Huang, Rong Zou, Yi Qu, Dezhi Mu
Obesity, overweight and autism spectrum disorder (ASD) remain serious public health problems. Although lots of studies have recently explored the association among obesity, overweight and ASD, the findings are inconsistent. Thus, we conducted a meta-analysis of epidemiological studies to examine the association among obesity, overweight and ASD. PubMed, Embase, and the Cochrane Library were used for literature searches to identify eligible studies published in English before November 15, 2016. Relevant studies estimating the association among obesity, overweight and ASD were included...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915839/risk-of-mortality-among-children-adolescents-and-adults-with-autism-spectrum-disorder-or-attention-deficit-hyperactivity-disorder-and-their-first-degree-relatives-a-protocol-for-a-systematic-review-and-meta-analysis-of-observational-studies
#13
Ferrán Catalá-López, Brian Hutton, Matthew J Page, Manuel Ridao, Jane A Driver, Adolfo Alonso-Arroyo, Jaume Forés-Martos, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia, Rafael Tabarés-Seisdedos
BACKGROUND: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are childhood onset neurodevelopmental disorders that may persist into adulthood. ASD and ADHD tend to run in families and may have a significant negative impact on the health and longevity of those with the disorder and their relatives. The aim of this study will be to analyze the risk of mortality among children, adolescents, and adults with ASD or ADHD and their first-degree relatives. METHODS/DESIGN: We will conduct a systematic review and meta-analysis of observational studies...
September 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28884333/supplement-intervention-associated-with-nutritional-deficiencies-in-autism-spectrum-disorders-a-systematic-review
#14
Yong-Jiang Li, Ya-Min Li, Da-Xiong Xiang
PURPOSE: Nutritional supplements have been used for correction of deficiencies that may occur in patient with autism spectrum disorder (ASD) and to improve core symptoms. We aim to provide current best evidence about supplements for nutritional deficiencies and core symptoms in children with ASD and to evaluate the effectiveness and safety. METHODS: A systematic literature search of scientific databases was performed to retrieve relevant randomized controlled trials...
September 7, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28879629/feasibility-of-coping-effectiveness-training-for-caregivers-of-children-with-autism-spectrum-disorder-a-genetic-counseling-intervention
#15
Christy Haakonsen Smith, Erin Turbitt, John Muschelli, Lori Leonard, Katie L Lewis, Brian Freedman, Michelle Muratori, Barbara B Biesecker
Caregivers of children with autism spectrum disorder (ASD) may find it difficult to feel a sense of control and to cope with the overall physical and emotional demands of caring for their child. While caregivers are able to successfully cope with a high level of stress, there are limits to their resources and abilities to cope over time. Genetic counselors working with affected families may be able to help parents more effectively manage stress related to the disorder. Few short-term interventions have been reported in genetic counseling yet implementation of evidence-based examples may be achievable...
September 6, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28878697/dietary-supplement-for-core-symptoms-of-autism-spectrum-disorder-where-are-we-now-and-where-should-we-go
#16
REVIEW
Yong-Jiang Li, Jian-Jun Ou, Ya-Min Li, Da-Xiong Xiang
Autism spectrum disorders (ASDs) are a class of severe and chronic conditions and core symptoms are deficits in social interaction, language communication impairments, and repetitive/stereotyped behavior. Given the limitations of available treatments and substantially increased prevalence of the disease, additional interventions are needed. Since the use of dietary supplements for ASD is of high prevalence, up-to-date information about those supplements are required for both parents and clinicians. Relevant articles were identified through a systematic search of PubMed, EMBASE, Cochrane library, and PsychINFO databases (through May 2017)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28869842/changes-in-intrinsic-local-connectivity-after-reading-intervention-in-children-with-autism
#17
Jose O Maximo, Donna L Murdaugh, Sarah O'Kelley, Rajesh K Kana
Most of the existing behavioral and cognitive intervention programs in autism spectrum disorders (ASD) have not been tested at the neurobiological level, thus falling short of finding quantifiable neurobiological changes underlying behavioral improvement. The current study takes a translational neuroimaging approach to test the impact of a structured visual imagery-based reading intervention on improving reading comprehension and assessing its underlying local neural circuitry. Behavioral and resting state functional MRI (rs-fMRI) data were collected from children with ASD who were randomly assigned to an Experimental group (ASD-EXP; n=14) and a Wait-list control group (ASD-WLC; n=14)...
September 1, 2017: Brain and Language
https://www.readbyqxmd.com/read/28861935/children-with-autism-spectrum-disorder-who-improve-with-fever-insights-from-the-simons-simplex-collection
#18
Rebecca Grzadzinski, Catherine Lord, Stephan J Sanders, Donna Werling, Vanessa H Bal
Literature indicates that some children with ASD may show behavioral improvements during fever; however, little is known about the behavioral profiles of these children. This study aims to (a) investigate the subset of children who show parent-reported behavioral improvements associated with fever and (b) compare the demographic, behavioral, and genetic characteristics of this subset of children to children whose parents report no change during fever. Parents of 2,152 children from the Simons Simplex Collection provided information about whether and in which areas their child improved during fever...
August 31, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28861651/parent-mediated-intervention-for-one-year-olds-screened-as-at-risk-for-autism-spectrum-disorder-a-randomized-controlled-trial
#19
Linda R Watson, Elizabeth R Crais, Grace T Baranek, Lauren Turner-Brown, John Sideris, Linn Wakeford, Jessica Kinard, J Steven Reznick, Katrina L Martin, Sallie W Nowell
Theoretically, interventions initiated with at-risk infants prior to the point in time a definitive autism spectrum disorder (ASD) diagnosis can be made will improve outcomes. Pursuing this idea, we tested the efficacy of a parent-mediated early intervention called Adapted Responsive Teaching (ART) via a randomized controlled trial with 87 one-year-olds identified by community screening with the First Year Inventory as at-risk of later ASD diagnoses. We found minimal evidence for main effects of ART on child outcomes...
August 31, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28856093/from-word-reading-to-multisentence-comprehension-improvements-in-brain-activity-in-children-with-autism-after-reading-intervention
#20
Donna L Murdaugh, Jose O Maximo, Claire E Cordes, Sarah E O'Kelley, Rajesh K Kana
BACKGROUND: Children with ASD show a unique reading profile characterized by decoding abilities equivalent to verbal abilities, but with lower comprehension skills. Neuroimaging studies have found recruitment of regions primarily associated with visual processing (e.g., fusiform gyrus and medial parietal cortex), but reduced activation in frontal and temporal regions, when reading in adults with ASD. The purpose of this study was to assess neural changes associated with an intense reading intervention program in children with ASD using three fMRI tasks of reading...
2017: NeuroImage: Clinical
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