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mesial temporal sclerosis

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https://www.readbyqxmd.com/read/28188304/-18-f-fdg-pet-patterns-of-surgical-success-and-failure-in-mesial-temporal-lobe-epilepsy
#1
Francine Chassoux, Eric Artiges, Franck Semah, Agathe Laurent, Elisabeth Landré, Baris Turak, Philippe Gervais, Badia-Ourkia Helal, Bertrand Devaux
OBJECTIVE: To search for [(18)F]-fluorodeoxyglucose (FDG)-PET patterns predictive of long-term prognosis in surgery for drug-resistant mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS). METHODS: We analyzed metabolic data with [(18)F]-FDG-PET in 97 patients with MTLE (53 female participants; age range 15-56 years) with unilateral HS (50 left) and compared the metabolic patterns, electroclinical features, and structural atrophy on MRI in patients with the best outcome after anteromesial temporal resection (Engel class IA, completely seizure-free) to those with a non-IA outcome, including suboptimal outcome and failure...
February 10, 2017: Neurology
https://www.readbyqxmd.com/read/28166327/neurological-autoantibody-prevalence-in-epilepsy-of-unknown-etiology
#2
Divyanshu Dubey, Abdulradha Alqallaf, Ryan Hays, Matthew Freeman, Kevin Chen, Kan Ding, Mark Agostini, Steven Vernino
Importance: Autoimmune epilepsy is an underrecognized condition, and its true incidence is unknown. Identifying patients with an underlying autoimmune origin is critical because these patients' condition may remain refractory to conventional antiseizure medications but may respond to immunotherapy. Objective: To determine the prevalence of neurological autoantibodies (Abs) among adult patients with epilepsy of unknown etiology. Design, Setting, and Participants: Consecutive patients presenting to neurology services with new-onset epilepsy or established epilepsy of unknown etiology were identified...
February 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28157273/a-novel-animal-model-of-acquired-human-temporal-lobe-epilepsy-based-on-the-simultaneous-administration-of-kainic-acid-and-lorazepam
#3
Friederike Kienzler-Norwood, Lara Costard, Chinmaya Sadangi, Philipp Müller, Valentin Neubert, Sebastian Bauer, Felix Rosenow, Braxton A Norwood
OBJECTIVE: Kainic acid (KA) is a potent glutamate analog that is used to induce neurodegeneration and model temporal lobe epilepsy (TLE) in rodents. KA reliably induces severe, prolonged seizures, that is, convulsive status epilepticus (cSE), which is typically fatal without pharmacologic intervention. Although the use of KA to model human epilepsy has proven unquestionably valuable for >30 years, significant variability and mortality continue to confound results. These issues are probably the consequence of cSE, an all-or-nothing response that is inherently capricious and uncontrollable...
February 2017: Epilepsia
https://www.readbyqxmd.com/read/28124054/metal-maps-of-sclerotic-hippocampi-of-patients-with-mesial-temporal-lobe-epilepsy
#4
Miloš Opačić, Aleksandar J Ristić, Danijela Savić, Vid Simon Šelih, Marko Živin, Dragoslav Sokić, Savo Raičević, Vladimir Baščarević, Ivan Spasojević
The loss of metal homeostasis has been implicated in the pathophysiology of mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). Here we applied laser ablation inductively coupled plasma mass spectrometry imaging to establish the spatial distribution of Zn, Fe, Cu and Mn in coronal sections of hippocampi of four patients with drug-resistant mTLE-HS who underwent amygdalohippocampectomy. Detailed maps of the metal concentrations in the different morphological areas/layers were built and analyzed...
January 26, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28104639/hippocampal-atrophy-is-associated-with-altered-hippocampus-posterior-cingulate-cortex-connectivity-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#5
Y C Shih, C E Tseng, F-H Lin, H H Liou, W Y I Tseng
BACKGROUND AND PURPOSE: Unilateral mesial temporal lobe epilepsy and hippocampal sclerosis have structural and functional abnormalities in the mesial temporal regions. To gain insight into the pathophysiology of the epileptic network in mesial temporal lobe epilepsy with hippocampal sclerosis, we aimed to clarify the relationships between hippocampal atrophy and the altered connection between the hippocampus and the posterior cingulate cortex in patients with mesial temporal lobe epilepsy with hippocampal sclerosis...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28067149/navigation-assisted-trans-inferotemporal-cortex-selective-amygdalohippocampectomy-for-mesial-temporal-lobe-epilepsy-preserving-the-temporal-stem
#6
Haruhiko Kishima, Amami Kato, Satoru Oshino, Naoki Tani, Tomoyuki Maruo, Hui Ming Khoo, Takufumi Yanagisawa, Kotaro Edakawa, Maki Kobayashi, Masataka Tanaka, Koichi Hosomi, Masayuki Hirata, Toshiki Yoshimine
OBJECTIVE: Selective amygdalohippocampectomy (SAH) can be used to obtain satisfactory seizure control in patients with mesial temporal lobe epilepsy (MTLE). Several SAH procedures have been reported to achieve satisfactory outcomes for seizure control, but none yield fully satisfactory outcomes for memory function. We hypothesized that preserving the temporal stem might play an important role. To preserve the temporal stem, we developed a minimally invasive surgical procedure, 'neuronavigation-assisted trans-inferotemporal cortex SAH' (TITC-SAH)...
March 2017: Neurological Research
https://www.readbyqxmd.com/read/28052106/a-prediction-algorithm-for-drug-response-in-patients-with-mesial-temporal-lobe-epilepsy-based-on-clinical-and-genetic-information
#7
Mariana S Silva-Alves, Rodrigo Secolin, Benilton S Carvalho, Clarissa L Yasuda, Elizabeth Bilevicius, Marina K M Alvim, Renato O Santos, Claudia V Maurer-Morelli, Fernando Cendes, Iscia Lopes-Cendes
Mesial temporal lobe epilepsy is the most common form of adult epilepsy in surgical series. Currently, the only characteristic used to predict poor response to clinical treatment in this syndrome is the presence of hippocampal sclerosis. Single nucleotide polymorphisms (SNPs) located in genes encoding drug transporter and metabolism proteins could influence response to therapy. Therefore, we aimed to evaluate whether combining information from clinical variables as well as SNPs in candidate genes could improve the accuracy of predicting response to drug therapy in patients with mesial temporal lobe epilepsy...
2017: PloS One
https://www.readbyqxmd.com/read/28043064/electrophysiological-resting-state-biomarker-for-diagnosing-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#8
Seung-Hyun Jin, Chun Kee Chung
The main aim of the present study was to evaluate whether resting-state functional connectivity of magnetoencephalography (MEG) signals can differentiate patients with mesial temporal lobe epilepsy (MTLE) from healthy controls (HC) and can differentiate between right and left MTLE as a diagnostic biomarker. To this end, a support vector machine (SVM) method among various machine learning algorithms was employed. We compared resting-state functional networks between 46 MTLE (right MTLE=23; left MTLE=23) patients with histologically proven HS who were free of seizure after surgery, and 46 HC...
November 23, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/28043058/epilepsy-surgery-in-drug-resistant-temporal-lobe-epilepsy-associated-with-neuronal-antibodies
#9
Mar Carreño, Christian G Bien, Ali A Asadi-Pooya, Michael Sperling, Petr Marusic, Martin Elisak, Jose Pimentel, Tim Wehner, Rajiv Mohanraj, Juan Uranga, Asier Gómez-Ibáñez, Vicente Villanueva, Francisco Gil, Antonio Donaire, Nuria Bargalló, Jordi Rumià, Pedro Roldán, Xavier Setoain, Luis Pintor, Teresa Boget, Eva Bailles, Mercè Falip, Javier Aparicio, Josep Dalmau, Francesc Graus
We assessed the outcome of patients with drug resistant epilepsy and neuronal antibodies who underwent epilepsy surgery. Retrospective study, information collected with a questionnaire sent to epilepsy surgery centers. Thirteen patients identified, with antibodies to GAD (8), Ma2 (2), Hu (1), LGI1 (1) or CASPR2 (1). Mean age at seizure onset: 23 years. Five patients had an encephalitic phase. Three had testicular tumors and five had autoimmune diseases. All had drug resistant temporal lobe epilepsy (median: 20 seizures/month)...
January 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28034810/prevalence-and-incidence-of-drug-resistant-mesial-temporal-lobe-epilepsy-in-the-united-states
#10
REVIEW
Ali A Asadi-Pooya, Gregory R Stewart, Daniel J Abrams, Ashwini Sharan
OBJECTIVE: We reviewed data on the epidemiology of epilepsy in the United States and estimated the prevalence and incidence of drug-resistant temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) based on extrapolation from the available data drawn from the literature. METHODS: We searched the electronic database PubMed on December 14, 2016 using the following search terms in the title: "epilepsy" OR "temporal lobe" OR "hippocampal sclerosis" AND "epidemiology" OR "prevalence" OR "incidence"...
December 26, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28031219/preoperative-automated-fibre-quantification-predicts-postoperative-seizure-outcome-in-temporal-lobe-epilepsy
#11
Simon S Keller, G Russell Glenn, Bernd Weber, Barbara A K Kreilkamp, Jens H Jensen, Joseph A Helpern, Jan Wagner, Gareth J Barker, Mark P Richardson, Leonardo Bonilha
Approximately one in every two patients with pharmacoresistant temporal lobe epilepsy will not be rendered completely seizure-free after temporal lobe surgery. The reasons for this are unknown and are likely to be multifactorial. Quantitative volumetric magnetic resonance imaging techniques have provided limited insight into the causes of persistent postoperative seizures in patients with temporal lobe epilepsy. The relationship between postoperative outcome and preoperative pathology of white matter tracts, which constitute crucial components of epileptogenic networks, is unknown...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28018680/distinctive-structural-and-effective-connectivity-changes-of-semantic-cognition-network-across-left-and-right-mesial-temporal-lobe-epilepsy-patients
#12
Xiaotong Fan, Hao Yan, Yi Shan, Kun Shang, Xiaocui Wang, Peipei Wang, Yongzhi Shan, Jie Lu, Guoguang Zhao
Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that gray matter atrophy of left mTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27995064/combined-18-f-fdg-pet-and-diffusion-tensor-imaging-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#13
Javier Aparicio, Mar Carreño, Núria Bargalló, Xavier Setoain, Sebastià Rubí, Jordi Rumià, Carles Falcón, Anna Calvo, Berta Martí-Fuster, Nelly Padilla, Teresa Boget, Luís Pintor, Antonio Donaire
OBJECTIVES: Several studies using (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) or diffusion tensor imaging (DTI) have found both temporal and extratemporal abnormalities in patients with mesial temporal lobe epilepsy with ipsilateral hippocampal sclerosis (MTLE-HS), but data are lacking about the findings of both techniques in the same patients. We aimed to determine whether the extent of (18)F-FDG-PET hypometabolism is related to DTI abnormalities. METHODS: Twenty-one patients with MTLE-HS underwent comprehensive preoperative evaluation; 18 (86%) of these underwent epilepsy surgery...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27989571/mapping-the-convergent-temporal-epileptic-network-in-left-and-right-temporal-lobe-epilepsy
#14
Peng Fang, Jie An, Ling-Li Zeng, Hui Shen, Shijun Qiu, Dewen Hu
Left and right mesial temporal lobe epilepsy (mTLE) with hippocampal sclerosis (HS) exhibits similar functional and clinical dysfunctions, such as depressive mood and emotional dysregulation, implying that the left and right mTLE may share a common network substrate. However, the convergent anatomical network disruption between the left and right HS remains largely uncharacterized. This study aimed to investigate whether the left and right mTLE share a similar anatomical network. We examined 43 (22 left, 21 right) mTLE patients with HS and 39 healthy controls using diffusion tensor imaging...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27984260/persistent-interictal-musical-hallucination-in-a-patient-with-mesial-temporal-sclerosis-related-epilepsy-first-case-report-and-etiopathological-hypothesis
#15
Paolo Borelli, Marcella Vedovello, Massimiliano Braga, Massimo Pederzoli, Sandro Beretta
Musical hallucination is a disorder of complex sound processing of instrumental music, songs, choirs, chants, etc. The underlying pathologies include moderate to severe acquired hearing loss (the auditory equivalent of Charles Bonnet syndrome), psychiatric illnesses (depression, schizophrenia), drug intoxication (benzodiazepines, salicylate, pentoxifylline, propranolol), traumatic lesions along the acoustic pathways, and epilepsy. The hallucinations are most likely to begin late in life; 70% of patients are women...
December 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27926529/altered-microrna-profiles-in-plasma-exosomes-from-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#16
Shaofeng Yan, Hua Zhang, Wenyan Xie, Fangang Meng, Kai Zhang, Yin Jiang, Xin Zhang, Jianguo Zhang
Mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) is the most common type of focal epilepsy. The present study aimed to explore the expression and functions of exosomal microRNAs in mTLE-HS. A total of 50 microRNAs were found to be differentially expressed in mTLE-HS compared with healthy controls. Among them, 2 were increased and 48 were decreased. The 6 significant differentially expressed candidate microRNAs (miR-3613-5p, miR-4668-5p, miR-8071, miR-197-5p, miR-4322, and miR-6781-5p ) in exosome were validated...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27889242/benign-mesial-temporal-lobe-epilepsy-a-clinical-cohort-and-literature-review
#17
Amal AlQassmi, Jorge G Burneo, Richard S McLachlan, Seyed M Mirsattari
OBJECTIVE: We present a single-center retrospective study of benign mesial temporal lobe epilepsy (bMTLE) between 1995 and 2014. METHODS: Hospital records and clinic charts were reviewed. The clinical, Eelectroencephalographic (EEG), imaging features, and response to treatment with antiepileptic drugs (AEDs) were documented. Patients were included in this study if they were seizure-free for a minimum of 24months with or without an AED. RESULTS: Twenty-seven patients were identified...
December 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27875923/age-of-onset-of-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis-the-effect-of-apolipoprotein-e-and-febrile-seizures
#18
Bárbara Leal, João Chaves, Cláudia Carvalho, Andreia Bettencourt, Joel Freitas, João Lopes, João Ramalheira, Paulo P Costa, Denisa Mendonça, António M Silva, Berta M Silva
PURPOSE: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is the most frequent pharmaco-resistant epilepsy. It has been associated with febrile seizures (FS) in childhood. Its aetiology remains unclear but genetic factors are involved. Apolipoprotein E (ApoE) is the main lipoprotein secreted in brain. It has a critical immunomodulatory function, influences neurotransmission and it is involved in repairing damaged neurons. ApoE ϵ4 is an isoform of ApoE with altered protein function, previously associated with refractoriness and early onset epilepsy...
December 12, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27864929/temporal-lobe-epilepsy-and-focal-cortical-dysplasia-in-children-a-tip-to-find-the-abnormality
#19
Luca Bartolini, Matthew T Whitehead, Cheng-Ying Ho, Leigh N Sepeta, Chima O Oluigbo, Kathryn Havens, Emily R Freilich, John M Schreiber, William D Gaillard
OBJECTIVE: To demonstrate an association between magnetic resonance imaging (MRI) findings and pathologic characteristics in children who had surgery for medically refractory epilepsy due to focal cortical dysplasia (FCD). METHODS: We retrospectively studied 110 children who had epilepsy surgery. Twenty-seven patients with FCD were included. Thirteen had temporal lobe epilepsy (TLE) and 14 had extra-temporal lobe epilepsy (ETLE). Three patients had associated mesial temporal sclerosis...
January 2017: Epilepsia
https://www.readbyqxmd.com/read/27794094/neurocysticercosis-in-bhutan-a-cross-sectional-study-in-people-with-epilepsy
#20
Kate Brizzi, Sonam Pelden, Tshokey Tshokey, Damber K Nirola, Megan B Diamond, Joshua P Klein, Lhab Tshering, Sonam Deki, Dechen Nidup, Veronica Bruno, Pierre Dorny, Hector Hugo Garcia, Farrah J Mateen
BACKGROUND: We sought to provide an assessment of the burden of neurocysticercosis among people with epilepsy (PWE) in Bhutan and evaluate the yield of various tests for Taenia solium. METHODS: PWE were enrolled at the National Referral Hospital in Thimphu (2014-2015). Serum was tested for anti-Taenia solium IgG using ELISA (Ab-ELISA), enzyme-linked immunoelectrotransfer blot (EITB), and parasite antigen. Results were compared to brain MRI. Participants were categorized as definite neurocysticercosis (MRI and EITB positive), probable neurocysticercosis (MRI or EITB positive), or without neurocysticercosis...
September 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
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