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https://www.readbyqxmd.com/read/29784190/randomized-trial-comparing-open-radical-cystectomy-and-robot-assisted-laparoscopic-radical-cystectomy-oncologic-outcomes
#1
Bernard H Bochner, Guido Dalbagni, Karim H Marzouk, Daniel D Sjoberg, Justin Lee, Sheri M Donat, Jonathan A Coleman, Andrew Vickers, Harry W Herr, Vincent P Laudone
BACKGROUND: Open radical cystectomy (ORC) has proven to be an important component in the treatment of high-risk bladder cancer (BCa). ORC surgical morbidity remains high; therefore, minimally invasive surgical techniques have been introduced in an attempt to improve patient outcomes. OBJECTIVE: To compare cancer outcomes in BCa patients managed with ORC or robotic-assisted radical cystectomy (RARC). DESIGN, SETTING, AND PARTICIPANTS: A prospective, randomized trial was completed between 2010 and 2013...
May 18, 2018: European Urology
https://www.readbyqxmd.com/read/29783036/retrospective-study-on-the-management-and-follow-up-of-18-patients-with-a-mid-urethral-sling-penetrating-the-urethra-or-bladder
#2
Edouard Goujon, Adélaide Jarniat, Florian Bardet, Lise Bergogne, Emmanuel Delorme
INTRODUCTION: The mid-urethral sling (MUS) procedure is the gold-standard for the surgical treatment of stress urinary incontinence (SUI). Urethro-vesical sling exposure is one of the most serious complications of this procedure. We describe the treatment and follow-up of 18 patients with bladder or urethral sling exposure. PATIENTS AND METHODS: This single-center, retrospective study assessed the diagnosis and management of MUS penetrating the lower urinary tract in 18 women...
May 18, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29777865/a-prospective-non-interventional-registry-study-of-patients-initiating-a-course-of-drug-therapy-for-overactive-bladder-perspective-rationale-design-and-methodology
#3
Eric S Rovner, Kevin V Carlson, Anna S Deal, Kavita V Nair, Eva E Oakkar, Julie Park, Eric Gemmen, Rita M Kristy, Katherine L Gooch, Carol R Schermer
INTRODUCTION: Pharmacotherapy of overactive bladder (OAB) typically involves treatment with an antimuscarinic or mirabegron, a β3-adrenoceptor agonist, but real-world evidence on their use, including treatment access, persistence, and switching, is limited. Here, we describe the design of a prospective, multicenter, non-interventional registry of patients beginning a new course of OAB pharmacological therapy in routine clinical practice. METHODS: Adults with an OAB diagnosis for at least 3 months who either initiated a new course of mirabegron or antimuscarinic, or who switched therapy were enrolled into PERSPECTIVE (A Prospective, Non-intErventional Registry Study of Patients Initiating a Course of Drug Therapy for OveractIVE Bladder)...
May 16, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29777787/patency-and-incontinence-rates-after-robotic-bladder-neck-reconstruction-for-vesicourethral-anastomotic-stenosis-and-recalcitrant-bladder-neck-contractures-the-turns-experience
#4
Eric J Kirshenbaum, Lee C Zhao, Jeremy B Myers, Sean P Elliott, Alex J Vanni, Nima Baradaran, Bradley A Erickson, Jill C Buckley, Bryan B Voelzke, Michael A Granieri, Stephen J Summers, Benjamin N Breyer, Atreya Dash, Aaron Weinberg, Nejd F Alsikafi
OBJECTIVE: To review a robotic approach to recalcitrant bladder neck obstruction and assess success and incontinence rates. METHODS: Patients with a recalcitrant bladder neck contracture or vesicourethral anastomotic stenosis who underwent robotic bladder neck reconstruction (RBNR) were identified. We reviewed patient demographics, medical history, etiology, previous endoscopic management, cystoscopic and symptomatic outcomes, urinary continence and complications...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29777786/photoselective-vaporisation-of-the-bladder-for-the-management-of-radiation-cystitis-technique-and-initial-outcomes
#5
Claire Pascoe, Daniel Christidis, Todd Manning, Benjamin W Lamb, Declan G Murphy, Nathan Lawrentschuk
Objective To describe our technique utilising photoselective vaporisation of the bladder (PVB) for the management of haemorrhagic cystitis and initial results of 12 patients. Materials and Method An audit of theatre records of a single surgeon was performed to identify patients who had undergone PVB for management of radiation-cystitis. TECHNIQUE: Rigid cystoscopy was performed. Ureteric catheters were placed and active bleeding sites targeted to optimise vision. Ablation was commenced using the vaporize function...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29777618/guideline-of-guidelines-bladder-pain-syndrome
#6
REVIEW
Sachin Malde, Stefano Palmisani, Adnan Al-Kaisy, Arun Sahai
Bladder pain syndrome (BPS) is a severely debilitating, chronic disorder of unknown aetiology that has a significant negative impact on quality of life. A community-based study of American women has reported a high prevalence of 2.7% - 6.5% [1]. Despite this, there is still a lack of consensus worldwide on how to define the condition, the nomenclature to use, and how to optimally treat patients. This is reflected in the considerable variation in management worldwide, and the divergent recommendations in national and international guidelines...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29774817/bladder-reconstruction-with-bowel-robot-assisted-laparoscopic-ileocystoplasty-with-mitrofanoff-appendicovesicostomy-in-pediatric-patients
#7
Nimrod S Barashi, Maria Veronica Rodriguez, Vignesh T Packiam, Mohan S Gundeti
Neurogenic bladder occur as a consequence of several conditions, most commonly posterior urethral valves syndrome, spina bifida, tethered cord, sacral agenesis, and Arnold-Chiari malformation. It is characterized by diminished bladder capacity and/or reduced compliance, associated with high-pressure voiding that can lead to deterioration of renal function if left untreated. When medical management fails, bladder reconstruction with bowel (aumentation ileocystoplasty) becomes the treatment of choice for these patients...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29772407/total-laparoscopic-hysterectomy-for-endometriosis-and-an-arteriovenous-malformation
#8
Emilie Schwartz, Emilie Faller, Chérif Youssef Akladios, Michel Greget, Catherine Roy, Arnaud Wattiez
STUDY OBJECTIVE: Demonstrate a laparoscopic management of an arteriovenous malformation in a patient with deep pelvic endometriosis DESIGN: A step-by-step explanation of the surgery using video (instructive video). SETTING: Hautepierre Universitary Hospital of Strasbourg in France INTERVENTION: We describe the case of a 37 years old patient presenting deep pelvic endometriosis and an uterine arteriovenous malformation. It was during a tubal ligation in 2015, that the deep pelvic endometriosis was diagnosed...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29771898/symptoms-of-bowel-dysfunction-and-their-management-after-spinal-cord-injury-in-a-new-zealand-centre
#9
Edwin P Arnold, Giovanni Losco, Sharon English, Frank Frizelle, Angelo Anthony
AIM: To document the symptoms of bowel dysfunction, and how the bowels are managed, in a cohort of patients following a spinal cord injury. To relate these to the level of the spinal injury and to examine the relationship between bowel symptoms and bladder dysfunction. METHOD: Participants were identified from the discharge data from the Burwood Spinal Unit, one of two national Spinal Units in New Zealand, in two two-year sets from 1-3 years post-injury and from 20-21 years post-injury...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29766842/continuous-low-dose-antibiotic-prophylaxis-to-prevent-urinary-tract-infection-in-adults-who-perform-clean-intermittent-self-catheterisation-the-antic-rct
#10
Robert Pickard, Thomas Chadwick, Yemi Oluboyede, Catherine Brennand, Alexander von Wilamowitz-Moellendorff, Doreen McClurg, Jennifer Wilkinson, Laura Ternent, Holly Fisher, Katherine Walton, Elaine McColl, Luke Vale, Ruth Wood, Mohamed Abdel-Fattah, Paul Hilton, Mandy Fader, Simon Harrison, James Larcombe, Paul Little, Anthony Timoney, James N'Dow, Heather Armstrong, Nicola Morris, Kerry Walker, Nikesh Thiruchelvam
BACKGROUND: People carrying out clean intermittent self-catheterisation (CISC) to empty their bladder often suffer repeated urinary tract infections (UTIs). Continuous once-daily, low-dose antibiotic treatment (antibiotic prophylaxis) is commonly advised but knowledge of its effectiveness is lacking. OBJECTIVE: To assess the benefit, harms and cost-effectiveness of antibiotic prophylaxis to prevent UTIs in people who perform CISC. DESIGN: Parallel-group, open-label, patient-randomised 12-month trial of allocated intervention with 3-monthly follow-up...
May 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29757662/a-review-of-the-surgical-management-of-perineal-hernias-in-dogs
#11
Sukhjit Singh Gill, Robert D Barstad
Perineal hernia refers to the failure of the muscular pelvic diaphragm to support the rectal wall, resulting in herniation of pelvic and, occasionally, abdominal viscera into the subcutaneous perineal region. The proposed causes of pelvic diaphragm weakness include tenesmus associated with chronic prostatic disease or constipation, myopathy, rectal abnormalities, and gonadal hormonal imbalances. The most common presentation of perineal hernia in dogs is a unilateral or bilateral nonpainful swelling of the perineum...
May 14, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29756588/toward-a-shared-care-model-of-relapsing-remitting-multiple-sclerosis-role-of-the-primary-care-practitioner
#12
Jiwon Oh, Marie-Sarah Gagné-Brosseau, Melanie Guenette, Catherine Larochelle, François Lemieux, Suresh Menon, Sarah A Morrow, Laurence Poliquin-Lasnier, Chantal Roy-Hewitson, Carolina Rush, Anne-Marie Trudelle, Paul S Giacomini
The objective of this study was to develop a shared-care model to enable primary-care physicians to participate more fully in meeting the complex, multidisciplinary healthcare needs of patients with multiple sclerosis (MS). DESIGN: The design consisted of development of consensus recommendations and a shared-care algorithm. PARTICIPANTS: A working group of 11 Canadian neurologists involved in the management of patients with MS were included in this study. MAIN MESSAGE: The clinical management of patients with multiple sclerosis is increasing in complexity as new disease-modifying therapies (DMTs) become available, and ongoing safety monitoring is required...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29755117/safety-anti-tumour-activity-and-pharmacokinetics-of-fixed-dose-shr-1210-an-anti-pd-1-antibody-in-advanced-solid-tumours-a-dose-escalation-phase-1-study
#13
Hongnan Mo, Jing Huang, Jiachen Xu, Xuelian Chen, Dawei Wu, Dong Qu, Xi Wang, Bo Lan, Xingyuan Wang, Jianping Xu, Honggang Zhang, Yihebali Chi, Qing Yang, Binghe Xu
BACKGROUND: To assess the safety profile, pharmacokinetics, pharmacodynamics and preliminary antitumour activity of fixed-dose SHR-1210, a novel anti-PD-1 antibody, in advanced solid tumours. METHODS: A total of 36 patients with advanced solid tumours received intravenous SHR-1210 at 60 mg, 200 mg and 400 mg (4-week interval after first dose followed by a 2-week schedule) until disease progression or intolerable toxicity. The concentration of SHR-1210 was detected for pharmacokinetics, and receptor occupancy on circulating T lymphocytes was assessed for pharmacodynamics...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29755116/health-related-quality-of-life-after-treatment-for-bladder-cancer-in-england
#14
Samantha J Mason, Amy Downing, Penny Wright, Luke Hounsome, Sarah E Bottomley, Jessica Corner, Mike Richards, James W Catto, Adam W Glaser
BACKGROUND: Little is known about quality of life after bladder cancer treatment. This common cancer is managed using treatments that can affect urinary, sexual and bowel function. METHODS: To understand quality of life and inform future care, the Department of Health (England) surveyed adults surviving bladder cancer 1-5 years after diagnosis. Questions related to disease status, co-existing conditions, generic health (EQ-5D), cancer-generic (Social Difficulties Inventory) and cancer-specific outcomes (Functional Assessment of Cancer Therapy-Bladder)...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29755006/multiparametric-magnetic-resonance-imaging-for-bladder-cancer-development-of-vi-rads-vesical-imaging-reporting-and-data-system
#15
REVIEW
Valeria Panebianco, Yoshifumi Narumi, Ersan Altun, Bernard H Bochner, Jason A Efstathiou, Shaista Hafeez, Robert Huddart, Steve Kennish, Seth Lerner, Rodolfo Montironi, Valdair F Muglia, Georg Salomon, Stephen Thomas, Hebert Alberto Vargas, J Alfred Witjes, Mitsuru Takeuchi, Jelle Barentsz, James W F Catto
CONTEXT: Management of bladder cancer (BC) is primarily driven by stage, grade, and biological potential. Knowledge of each is derived using clinical, histopathological, and radiological investigations. This multimodal approach reduces the risk of error from one particular test, but may present a staging dilemma when results conflict. Multiparametric magnetic resonance imaging (mpMRI) may improve patient care through imaging of the bladder with better resolution of the tissue planes than computed tomography and without radiation exposure...
May 10, 2018: European Urology
https://www.readbyqxmd.com/read/29754838/-bcg-infection-following-intravesicular-immunotherapy-for-bladder-cancer
#16
REVIEW
L Levi, M Groh, N De Castro, A Bergeron, F Schlemmer
BACKGROUND: Bacille of Calmette et Guérin (BCG) immunotherapy is the most effective treatment for non-muscle-invasive bladder cancer. Yet, potentially severe localized or systemic mycobacterial infections can happen. STATE OF KNOWLEDGE: In a patient who underwent BCG instillation for bladder cancer, the diagnosis of BCG infection is usually suggested by more than 3 days of high-grade fever and systemic and/or local symptoms with no other plausible alternative diagnosis...
May 10, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29753705/spinal-cord-injury-how-could-acupuncture-help
#17
REVIEW
Qianqian Fan, Omer Cavus, Lize Xiong, Yun Xia
Spinal cord injury (SCI) is one of the most common causes of death and disability worldwide, and it can result in both permanent disability and serial complications in patients. Research shows that patients with SCI complications are often interested in acupuncture for symptomatic relief. Therefore, the issue of physicians advising their patients regarding the use of acupuncture to alleviate SCI complications becomes pertinent. We review and summarize two types of relevant publications: (1) literature concerning acupuncture for SCI and its complications and (2) underlying mechanisms of acupuncture therapy for SCI...
May 10, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29753647/translating-promising-strategies-for-bowel-and-bladder-management-in-spinal-cord-injury
#18
REVIEW
Tracey L Wheeler, William de Groat, Kymberly Eisner, Anton Emmanuel, Jennifer French, Warren Grill, Michael J Kennelly, Andrei Krassioukov, Bruno Gallo-Santacruz, Fin Biering-Sørensen, Naomi Kleitman
Loss of control over voiding following spinal cord injury (SCI) impacts autonomy, participation and dignity, and can cause life-threatening complications. The importance of SCI bowel and bladder dysfunction warrants significantly more attention from researchers in the field. To address this gap, key SCI clinicians, researchers, government and private funding organizations met to share knowledge and examine emerging approaches. This report reviews recommendations from this effort to identify and prioritize near-term treatment, investigational and translational approaches to addressing the pressing needs of people with SCI...
May 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29752972/urologic-phenotype-and-patterns-of-care-in-patients-with-megacystis-microcolon-intestinal-hypoperistalsis-syndrome-presenting-to-a-major-pediatric-transplantation-center
#19
Lee A Hugar, Rajeev Chaudhry, Thomas W Fuller, Glenn M Cannon, Francis X Schneck, Michael C Ost, Heidi A Stephany
OBJECTIVES: To describe the phenotype, referral pattern, and trends of urologic management for children with megacystis microcolon intestinal hypoperistalsis syndrome. METHODS: We performed a retrospective review of all patients with megacystis microcolon intestinal hypoperistalsis syndrome treated at a large tertiary children's medical center over a 14-year period. Our primary outcomes included the rate of urology referral, urodynamic characteristics of bladder function, and the proportion of patients managed with clean intermittent catheterization...
May 9, 2018: Urology
https://www.readbyqxmd.com/read/29750666/pd-l1-immunohistochemistry-assay-concordance-in-urothelial-carcinoma-of-the-bladder-and-hypopharyngeal-squamous-cell-carcinoma
#20
Anjelica Hodgson, Elzbieta Slodkowska, Achim Jungbluth, Stanley K Liu, Danny Vesprini, Danny Enepekides, Kevin Higgins, Nora Katabi, Bin Xu, Michelle R Downes
Programmed death ligand-1 (PD-L1) immunohistochemistry is used to guide treatment decisions regarding the use of checkpoint immunotherapy in the management of urothelial carcinoma of the bladder and hypopharyngeal (HP) squamous cell carcinoma. With increasing PD-L1 testing options, a need has arisen to assess the analytical comparability of diagnostic assays in order to develop a more sustainable testing strategy. Using tissue microarrays, PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was manually scored in 197 cases and 27 cases of bladder and HP cancer, respectively...
May 10, 2018: American Journal of Surgical Pathology
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