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Spinal stimulation

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https://www.readbyqxmd.com/read/29907903/the-chemokine-ccl4-mip-1%C3%AE-evokes-antinociceptive-effects-in-mice-a-role-for-cd4-lymphocytes-and-met-enkephalin
#1
Mario García-Domínguez, Ana Lastra, Alicia R Folgueras, Rafael Cernuda-Cernuda, María Teresa Fernández-García, Agustín Hidalgo, Luis Menéndez, Ana Baamonde
In the present study, we characterize the antinociceptive effects produced by the chemokine CCL4 in mice. The intraplantar administration of very low doses of CCL4 (0.1-3 pg) produced bilateral antinociception assessed by the unilateral hot-plate test (UHP) without evoking chemotactic responses at the injection site. Moreover, the subcutaneous administration of CCL4 (3-100 pg/kg) also yielded bilateral antinociception in the UHP and the paw pressure test and reduced the number of spinal neurons that express Fos protein in response to noxious stimulation...
June 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29907388/assessment-of-the-corticospinal-fiber-integrity-in-mirror-movement-disorder
#2
Bilgehan Solmaz, Mustafa Görkem Özyurt, Demir Berk Ata, Fulya Akçimen, Mohammed Shabsog, Kemal Sıtkı Türker, Hakkı Dalçik, Oktay Algin, Ayşe Nazlı Başak, Merve Özgür, Safiye Çavdar
Mirror movements are unintended movements occurring on one side of the body that mirror the contralateral voluntary ones. It has been proposed that mirror movements occur due to abnormal decussation of the corticospinal pathways. Using detailed multidisciplinary approach, we aimed to enlighten the detailed mechanism underlying the mirror movements in a case subject who is diagnosed with mirror movements of the hands and we compared the findings with the unaffected control subjects. To evaluate the characteristics of mirror movements, we used several techniques including whole exome sequencing, computed tomography, diffusion tensor imaging and transcranial magnetic stimulation...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29905973/effects-of-teriparatide-and-vibration-on-bone-mass-and-bone-strength-in-people-with-bone-loss-and-spinal-cord-injury-a-randomized-controlled-trial
#3
W Brent Edwards, Narina Simonian, Ifaz T Haider, Alan S Anschel, David Chen, Keith E Gordon, Elaine K Gregory, Ki H Kim, Ramadevi Parachuri, Karen L Troy, Thomas J Schnitzer
Spinal cord injury (SCI) is associated with marked bone loss and an increased risk of fracture. We randomized 61 individuals with chronic SCI and low bone mass to receive either: teriparatide 20 µg/day plus sham vibration 10 min/day (n = 20), placebo plus vibration 10 min/day (n = 20), or teriparatide 20 µg/day plus vibration 10 min/day (n = 21). Patients were evaluated for 12 months; those who completed were given the opportunity to participate in an open-label extension where all participants (n = 25) received teriparatide 20 µg/day for an additional 12 months and had the optional use of vibration (10 min/day)...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905656/pain-processing-in-the-human-brainstem-and-spinal-cord-before-during-and-after-the-application-of-noxious-heat-stimuli
#4
P W Stroman, G Ioachim, J M Powers, R Staud, C Pukall
Descending regulation of spinal cord responses to nociceptive signaling has a strong influence on pain perception. Prior studies using functional magnetic resonance imaging (fMRI) have indicated that in addition to reactive responses to nociceptive signals there is a continuous component to regulation, and that it may vary with differences in pain sensitivity. We hypothesize that this continuous regulation component occurs routinely in fMRI studies prior to noxious stimulation, as well as during, and following stimulation...
June 12, 2018: Pain
https://www.readbyqxmd.com/read/29904685/data-highlighting-the-effects-of-spinal-segmental-stimulation-of-preganglionic-sympathetic-neurons-on-the-electrophysiology-of-the-rabbit-heart
#5
Reshma A Chauhan, John Coote, Emily Allen, Pott Pongpaopattanakul, Kieran E Brack, G Andre Ng
This article presents data highlighting the functional selectivity of cardiac preganglionic sympathetic neurons in the rabbit heart. Specifically, the data draw attention to the role of each spinal segmental outflow on cardiac electrophysiology and the influence of each segment on cardiac excitability through investigating markers of arrhythmia such as electrical restitution. This data holds importance for exploring whether the preganglionic sympathetic neurons have functionally distinct pathways to the heart and whether some spinal segmental outflows have a greater potential for arrhythmia generation than others...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29903620/computational-motility-models-of-neurogastroenterology-and-neuromodulation
#6
Bradley B Barth, Xiling Shen
The success of neuromodulation therapies, particularly in the brain, spinal cord, and peripheral nerves, has been greatly aided by computational, biophysical models. However, treating gastrointestinal disorders with electrical stimulation has been much less explored, partly because the mode of action of such treatments is unclear, and selection of stimulation parameters is often empirical. Progress in gut neuromodulation is limited by the comparative lack of biophysical models capable of simulating neuromodulation of gastrointestinal function...
August 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29896261/electro-acupuncture-stimulation-prevents-remifentanil-induced-postoperative-hyperalgesia-by-suppressing-spinal-microglia-in-rats
#7
Yanhu Xie, Jun Ma, Di Wang, Xiaoqing Chai, Chen Gao
The aim of the present study was to assess the effect of electro-acupuncture (EA) stimulation on remifentanil-induced postoperative hyperalgesia (RIPH) and the possible involvement of spinal microglia suppression. A model of RIPH was established using adult male Sprague-Dawley rats by administration of remifentanil at 0.08 mg/kg intravenously for 60 min. The Huantiao and Yanglingquan acupoints were stimulated continuously by EA (2 Hz, ~1 mA) for 90 min from before paw incision to the end of remifentanil administration...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896101/activation-of-a2a-receptor-by-pdrn-reduces-neuronal-damage-and-stimulates-wnt-%C3%AE-catenin-driven-neurogenesis-in-spinal-cord-injury
#8
Natasha Irrera, Vincenzo Arcoraci, Federica Mannino, Giovanna Vermiglio, Giovanni Pallio, Letteria Minutoli, Gianluca Bagnato, Giuseppe Pio Anastasi, Emanuela Mazzon, Placido Bramanti, Francesco Squadrito, Domenica Altavilla, Alessandra Bitto
Spinal cord injury (SCI) is a complex clinical and progressive condition characterized by neuronal loss, axonal destruction and demyelination. In the last few years, adenosine receptors have been studied as a target for many diseases, including neurodegenerative conditions. The aim of this study was to investigate the effects of an adenosine receptor agonist, PDRN, in an experimental model of SCI. Moreover, since adenosine receptors stimulation may also activate the Wnt pathway, we wanted to study PDRN effects on Wnt signaling following SCI...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29895879/does-trans-spinal-direct-current-stimulation-modulate-the-hoffmann-reflexes-of-healthy-individuals-a-systematic-review-and-meta-analysisc
#9
REVIEW
Plínio Luna Albuquerque, Thyciane Mendonça, Mayara Campêlo, Lívia Shirahige, Kátia Monte-Silva
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVES: To summarize the available evidence regarding the effects of trans-spinal direct current stimulation (tsDCS) on spinal monosynaptic circuit excitability in healthy individuals. SETTING: Applied Neuroscience Laboratory, Brazil. METHODS: Abstract screening was performed independently by two authors for studies found in the following databases: PubMed, CINAHL, PsycINFO, Web of Science, and LILACS...
June 12, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29895874/intermittent-theta-burst-stimulation-for-upper-limb-dysfunction-and-spasticity-in-spinal-cord-injury-a-single-blind-randomized-feasibility-study
#10
Aref-Ali Gharooni, Krishnan Padmakumari Sivaraman Nair, Debby Hawkins, Ian Scivill, Daniel Hind, Ram Hariharan
STUDY DESIGN: Single-blind, sham-controlled, crossover randomized feasibility study OBJECTIVES: (1) Assess the feasibility of a full-scale trial of intermittent theta-burst stimulation (iTBS) for upper-limb sensorimotor dysfunction following spinal cord injury (SCI). (2) Determine the safety and tolerability of iTBS over primary motor cortex on upper-limb function in people with spinal cord injury (SCI). SETTING: Large Tertiary Spinal Injuries Centre METHODS: Participants with incomplete SCI, suffering with upper-limb spasticity were recruited and randomized to receive active/sham iTBS over the hand representation of the primary motor cortex...
June 12, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29895449/kinematics-based-prediction-of-trunk-muscle-activity-in-response-to-multi-directional-perturbations-during-sitting
#11
Jacques Bobet, Kei Masani, Milos R Popovic, Albert H Vette
Recent work suggests that functional electrical stimulation can be used to enhance dynamic trunk stability following spinal cord injury. In this context, knowledge of the relation between trunk kinematics and muscle activation in non-disabled individuals may assist in developing kinematics-based neuroprostheses. Our objective was therefore to predict the activation profiles of the major trunk muscles from trunk kinematics following multi-directional perturbations during sitting. Trunk motion and electromyograms (EMG) from ten major trunk muscles were acquired in twelve non-disabled, seated individuals who experienced a force of approximately 200 N applied to the trunk in eight horizontal directions...
June 9, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29893910/brief-electrical-stimulation-promotes-nerve-regeneration-following-experimental-in-continuity-nerve-injury
#12
Yuval Shapira, Vanessa Sammons, Joanne Forden, Gui Fang Guo, Alexander Kipp, Jill Girgulis, Tanmay Mishra, Jacob Daniel de Villers Alant, Rajiv Midha
BACKGROUND: Brief electrical stimulation (ES) therapy to the nerve may improve outcome in lacerated, repaired nerves. However, most human nerve injuries leave the nerve in continuity with variable and often poor functional recovery from incomplete axon regeneration and reinnervation. OBJECTIVE: To evaluate the effect of brief ES in an experimental model for neuroma-in-continuity (NIC) injuries in rodents. METHODS: Lewis rats were randomly assigned to 1 of 4 groups: NIC injury immediately followed by brief (1 h) ES; NIC injury without ES; sham-operated controls; sciatic nerve transection without repair...
June 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29890702/cellular-and-molecular-mediators-of-bone-metastatic-lesions
#13
REVIEW
Giulia Battafarano, Michela Rossi, Francesco Marampon, Andrea Del Fattore
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling activity, and displaying some features of bone cells. This interplay between tumor and bone cells alters the physiological bone remodeling, leading to the generation of a vicious cycle that promotes bone metastasis growth. To prevent the skeletal-related events (SRE) associated with bone metastasis, approaches to inhibit osteoclast bone resorption are reported...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29890210/the-rostral-medulla-of-bullfrog-tadpoles-contains-critical-lung-rhythmogenic-and-chemosensitive-regions-across-metamorphosis
#14
Mitchell D Reed, Kimberly E Iceman, Michael B Harris, Barbara E Taylor
The development of amphibian breathing provides insight into vertebrate respiratory control mechanisms. Neural oscillators in the rostral and caudal medulla drive ventilation in amphibians, and previous reports describe ventilatory oscillators and CO2 sensitive regions arise during different stages of amphibian metamorphosis. However, inconsistent findings have been enigmatic, and make comparisons to potential mammalian counterparts challenging. In the current study we assessed amphibian central CO2 responsiveness and respiratory rhythm generation during two different developmental stages...
June 8, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29889356/spinal-cord-stimulation-scs-trial-outcomes-after-conversion-to-a-multiple-waveform-scs-system
#15
Nameer Haider, Dwight Ligham, Brett Quave, Kirk E Harum, Eduardo A Garcia, Christopher A Gilmore, Nathan Miller, Gregory A Moore, Amarpreet Bains, Kristen Lechleiter, Roshini Jain
OBJECTIVE: Spinal cord stimulation (SCS) for chronic intractable pain is typically delivered in pulses, classically programmed between approximately 20 and 100 Hz. Though some recent studies suggest that better pain relief is obtained, with only 10 kHz stimulation, other studies show that single-therapy trials do not always lead to permanent implantation. We evaluated SCS outcomes in subjects given trials with multiple waveforms who did not experience satisfactory trial relief with 10 kHz stimulation only...
June 11, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29889116/does-galvanic-vestibular-stimulation-decrease-spasticity-in-clinically-complete-spinal-cord-injury
#16
Radoje D Čobeljić, Ksenija Ribarič-Jankes, Antonina Aleksić, Lana Z Popović-Maneski, Laszlo B Schwirtlich, Dejan B Popović
The aim of this study was to determine changes in clinical and biomechanical measures of spasticity after administering galvanic vestibular stimulation in patients with a complete spinal cord injury (SCI). The spasticity in the lower limbs was assessed using the Modified Ashworth Scale and the pendulum test in seven SCI patients (grade A on the ASIA Impairment Scale) before (0), immediately after (0), and at 5 and 30 min after the real versus sham galvanic vestibular stimulation (15 s each, anode over the right mastoid)...
June 7, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29889084/phenelzine-a-small-organic-compound-mimicking-the-functions-of-cell-adhesion-molecule-l1-promotes-functional-recovery-after-mouse-spinal-cord-injury
#17
Rong Li, Sudhanshu Sahu, Melitta Schachner
BACKGROUND: Neural cell adhesion molecule L1 contributes to nervous system development and maintenance by promoting neuronal survival, neuritogenesis, axonal regrowth/sprouting, myelination, and synapse formation and plasticity. L1 also enhances recovery after spinal cord injury and ameliorates neurodegenerative processes in experimental rodent models. Aiming for clinical translation of L1 into therapy we screened for and functionally characterized in vitro the small organic molecule phenelzine, which mimics characteristic L1 functions...
June 6, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29888571/-stimulating-frequency-dependent-analgesic-effect-of-electroacupuncture-via-down-regulating-expression-of-vegf-in-dorsal-horns-of-lumbar-spinal-cord-in-post-herpetic-neuralgia-rats
#18
Cai-Hua Wu, Hong-Rong Mao, Hong-Ping Li, Xiao-Cui Yuan, Hong-Chun Xiang, He Zhu, Man Li
OBJECTIVE: To observe the effect of different frequencies of electroacupuncture (EA) stimulation on pain threshold (PT) and expression of vascular endothelial growth factor (VEGF) in dorsal horns (DHs) of the lumbar spinal cord in resiniferatoxin (RTX)-induced post-herpetic neuralgia (PHN) rats, so as to reveal its mechanism in alleviating PHN. METHODS: Male SD rats were randomized into control, model, 2 Hz-EA, 15 Hz-EA, 100 Hz-EA and sham EA groups ( n =16 in each)...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29888402/a-3d-magnetic-hyaluronic-acid-hydrogel-for-magnetomechanical-neuromodulation-of-primary-dorsal-root-ganglion-neurons
#19
Andy Tay, Ali Sohrabi, Kate Poole, Stephanie Seidlits, Dino Di Carlo
Neuromodulation tools are useful to decipher and modulate neural circuitries implicated in functions and diseases. Existing electrical and chemical tools cannot offer specific neural modulation while optogenetics has limitations for deep tissue interfaces, which might be overcome by miniaturized optoelectronic devices in the future. Here, a 3D magnetic hyaluronic hydrogel is described that offers noninvasive neuromodulation via magnetomechanical stimulation of primary dorsal root ganglion (DRG) neurons. The hydrogel shares similar biochemical and biophysical properties as the extracellular matrix of spinal cord, facilitating healthy growth of functional neurites and expression of excitatory and inhibitory ion channels...
June 10, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29888265/hydrogen-rich-saline-activated-autophagy-via-hif-1-%C3%AE-pathways-in-neuropathic-pain-model
#20
Huixing Wang, Xiaodong Huo, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Xiaojuan Wang, Keliang Xie, Yonghao Yu, Kemei Shi
Background: Neuropathic pain is a chronic and intractable pain, with very few effective analgesics. It involves an impaired cell autophagy process. Hydrogen-rich saline (HRS) reportedly reduces allodynia and hyperalgesia in a neuropathic pain model; however, it is unknown whether these effects involve autophagy induction. Methods: We investigated the relationship between HRS and cell autophagy in a neuropathic pain model generated by chronic constriction injury (CCI) in Sprague-Dawley rats...
2018: BioMed Research International
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