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https://www.readbyqxmd.com/read/29026942/the-effects-of-subclinical-neck-pain-on-sensorimotor-integration-following-a-complex-motor-pursuit-task
#1
Danielle Andrew, Paul Yielder, Heidi Haavik, Bernadette Murphy
Recurrent subclinical neck pain (SCNP) may be associated with neural plastic changes in sensory processing and sensorimotor integration (SMI); however, its impact on motor learning has not been investigated. The aim of this study was to investigate whether SCNP alters neural markers of SMI during a complex motor acquisition task as compared to a healthy control group. Peripheral N9, spinal N13, brainstem N18, and cortical N20, P25, N24 and N30 early somatosensory evoked potentials (SEPs) were recorded following median nerve stimulation for 24 participants (12 control and 12 SCNP) before and after a 10-min tracing motor task intervention...
October 12, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29026048/spinal-cord-stimulation-for-chronic-non-cancer-pain-a-review-of-current-evidence-and-practice
#2
S Sc Wong, C W Chan, C W Cheung
Spinal cord stimulation provides analgesia through electrical stimulation of the dorsal column of the spinal cord via electrode leads placed into the epidural space. In traditional tonic stimulation, a painful sensation is replaced with paraesthesia. Spinal cord stimulation is effective in reducing neuropathic pain, enhancing function, and improving quality of life in different chronic pain conditions. Currently, there is most evidence to support its use for failed back surgery syndrome when multidisciplinary conventional management is unsuccessful...
October 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29025152/cervical-myelopathy-secondary-to-metallic-irritation-of-the-dura-mater-following-insertion-of-a-spinal-cord-stimulator-in-a-patient-with-ossification-of-posterior-longitudinal-ligament
#3
Jung Eun Kim, Jae Hyuk Yang, Mi Kyoung Lee, Seung Woo Suh, Sung Wook Kang
No abstract text is available yet for this article.
August 29, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29021917/a-feasibility-pilot-using-telehealth-videoconference-monitoring-of-home-based-nmes-resistance-training-in-persons-with-spinal-cord-injury
#4
Ashraf S Gorgey, Robert M Lester, Rodney C Wade, Refka E Khalil, Rehan K Khan, Melodie L Anderson, Teodoro Castillo
INTRODUCTION: The objective of the study was to investigate the feasibility and initial efficacy of telehealth communication in conjunction with surface neuromuscular electrical stimulation (NMES) resistance training (RT) to induce muscle hypertrophy. MATERIALS AND METHODS: This was a home-based setting of within-subject control design of trained vs controlled limbs. Five men with chronic (>1 year postinjury) motor-complete spinal cord injury (SCI) participated in a twice-weekly telehealth videoconference program using home-based NMES-RT for 8 weeks...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29020054/a-novel-approach-for-automatic-visualization-and-activation-detection-of-evoked-potentials-induced-by-epidural-spinal-cord-stimulation-in-individuals-with-spinal-cord-injury
#5
Samineh Mesbah, Claudia A Angeli, Robert S Keynton, Ayman El-Baz, Susan J Harkema
Voluntary movements and the standing of spinal cord injured patients have been facilitated using lumbosacral spinal cord epidural stimulation (scES). Identifying the appropriate stimulation parameters (intensity, frequency and anode/cathode assignment) is an arduous task and requires extensive mapping of the spinal cord using evoked potentials. Effective visualization and detection of muscle evoked potentials induced by scES from the recorded electromyography (EMG) signals is critical to identify the optimal configurations and the effects of specific scES parameters on muscle activation...
2017: PloS One
https://www.readbyqxmd.com/read/29018896/hypericum-perforatum-extract-modulates-cortical-plasticity-in-humans
#6
Carmen Concerto, Hyunji Boo, Charles Hu, Priam Sandilya, Anita Krish, Eileen Chusid, Diego Coira, Eugenio Aguglia, Fortunato Battaglia
BACKGROUND: Hypericum perforatum (HYP) extract is one of the most commonly used complementary alternative medicines (CAMs) for the treatment of mild-to-moderate depression. Non-invasive brain stimulation protocols can be used to investigate the effect of psychoactive substances on the human brain. In this study, we explored the effect of a single dose of HYP extract (WS 5570) intake on corticospinal excitability and plasticity in humans. METHODS: Twenty-eight healthy subjects were required to intake 900 mg of either HYP extract or placebo...
October 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29017400/minimally-invasive-method-to-activate-the-expiratory-muscles-to-restore-cough
#7
Anthony F DiMarco, Robert T Geertman, Kutaiba Tabbaa, Rebecca R Polito, Krzysztof E Kowalski
CONTEXT: Spinal cord stimulation (SCS) via disc electrodes surgically placed via laminotomy incisions has been shown to restore an effective cough in subjects with spinal cord injury (SCI). The purpose of this study was to evaluate a new method of expiratory muscle activation utilizing spinal cord wire leads, which can be implanted with minimally invasive techniques. METHODS: In a subject with SCI, parallel wire leads with two electrode contacts were inserted percutaneously through a needle, advanced to the T9, T11 spinal levels and connected to an implanted radiofrequency receiver...
October 11, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29016994/neuromodulation-in-postherpetic-neuralgia-case-reports-and-review-of-the-literature
#8
Svetlana Kurklinsky, Scott C Palmer, Mack J Arroliga, Salim M Ghazi
Objective: Postherpetic neuralgia (PHN) is common in the United States. Current treatment options for PHN are fairly limited. Spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) are considered mostly experimental and still rarely performed in patients with PHN. Design: Two case reports and a review of the literature. Setting: Tertiary academic medical center. Methods: 1) Pubmed, Ovid, and EBMR databases were searched for all reports that had the following key words: postherpetic neuralgia, spinal cord stimulation, and peripheral nerve stimulation...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28987766/nervous-system-excitability-and-joint-stiffness-following-short-term-dynamic-ankle-immobilization
#9
Alyssa M Stirling, Jeffrey M McBride, Edward K Merritt, Alan R Needle
Joint immobilization has been demonstrated to modify neural excitability in subsets of healthy populations, leading to disinhibition of cortical and reflexive pathways. However, these findings may have limited clinical application as most models have investigated casting and rigid immobilization, while many musculoskeletal injuries often utilize dynamic immobilization devices such as boot immobilizers and pneumatic splints that allow for modified ambulation. We therefore aimed to determine the short-term effects of ambulation in ankle immobilization devices on nervous system excitability and stiffness in able-bodied individuals...
September 23, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28986411/virtual-reality-improves-embodiment-and-neuropathic-pain-caused-by-spinal-cord-injury
#10
Polona Pozeg, Estelle Palluel, Roberta Ronchi, Marco Solcà, Abdul-Wahab Al-Khodairy, Xavier Jordan, Ammar Kassouha, Olaf Blanke
OBJECTIVE: To investigate changes in body ownership and chronic neuropathic pain in patients with spinal cord injury (SCI) using multisensory own body illusions and virtual reality (VR). METHODS: Twenty patients with SCI with paraplegia and 20 healthy control participants (HC) participated in 2 factorial, randomized, repeated-measures design studies. In the virtual leg illusion (VLI), we applied asynchronous or synchronous visuotactile stimulation to the participant's back (either immediately above the lesion level or at the shoulder) and to the virtual legs as seen on a VR head-mounted display...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28982974/protein-kinase-a-induced-internalization-of-slack-channels-from-the-neuronal-membrane-occurs-by-adaptor-protein-2-clathrin-mediated-endocytosis
#11
Sushmitha Gururaj, Katherine M Evely, Kerri D Pryce, Jun Li, Jun Qu, Arin Bhattacharjee
The sodium-activated potassium (KNa) channel Kcnt1 (Slack) is abundantly expressed in nociceptor (pain sending) neurons of the dorsal root ganglion (DRG), where they transmit the large outward conductance IKNa and arbitrate membrane excitability. Slack channel expression at the DRG membrane is necessary for their characteristic firing accommodation during maintained stimulation, and reduced membrane channel density causes hyperexcitability. We have previously shown that in a pro-inflammatory state, a decrease in membrane channel expression leading to reduced Slack-mediated IKNa expression underlies DRG sensitization...
October 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28980850/rilmenidine-promotes-mtor-independent-autophagy-in-the-mutant-sod1-mouse-model-of-amyotrophic-lateral-sclerosis-without-slowing-disease-progression
#12
Nirma D Perera, Rebecca K Sheean, Chew L Lau, Yea Seul Shin, Philip M Beart, Malcolm K Horne, Bradley J Turner
Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence that autophagy is compromised in neurodegenerative disorders, which may contribute to cytoplasmic sequestration of aggregation-prone and toxic proteins in neurons. Genetic or pharmacological modulation of autophagy to promote clearance of misfolded proteins may be a promising therapeutic avenue for these disorders...
October 5, 2017: Autophagy
https://www.readbyqxmd.com/read/28980364/neuropathic-pain-medication-use-does-not-alter-outcomes-of-spinal-cord-stimulation-for-lower-extremity-pain
#13
Dermot P Maher, Yuri Chaves Martins, Tina Doshi, Mark Bicket, Kui Zhang, George Hanna, Shihab Ahmed
INTRODUCTION: Spinal cord stimulation (SCS) for the treatment of lower extremity pain is believed to the result of increased activity in the descending inhibitory and decreased activity in the ascending excitatory tracts. Evidence suggests that the analgesia afforded by SCS may be altered using certain neuropathic pain medications that also modulate neurotransmitters in these sensory tracts. We hypothesize that neuropathic pain medications may alter the response to SCS therapy. METHODS: One hundred and fifteen subjects undergoing SCS therapy for lower extremity pain were retrospectively examined...
October 4, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28978123/iaspp-overexpression-is-associated-with-clinical-outcome-in-spinal-chordoma-and-influences-cellular-proliferation-invasion-and-sensitivity-to-cisplatin-in-vitro
#14
Yunlong Ma, Bin Zhu, Xiaoguang Liu, Zhongjun Liu, Liang Jiang, Feng Wei, Miao Yu, Fengliang Wu, Hua Zhou, Nanfang Xu, Xiao Liu, Lei Yong, Yongqiang Wang, Peng Wang, Chen Liang, Guanping He
The oncogenetic function of inhibitory member of the apoptosis stimulating protein of p53 family (iASPP) in chordoma is unclear and remains to elucidate. The expression of iASPP in chordoma tissues and cells, its correlation to clinicopathological parameters and the effect on the patients' prognosis were evaluated. Cellular proliferation, invasion and cisplatin-response were observed after the iASPP knockdown or overexpression in vitro. Co-Immunoprecipitation assay was used to explore the interaction between iASPP and p53...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975677/sacral-neuromodulation-standardized-electrode-placement-technique
#15
Klaus E Matzel, Emmanuel Chartier-Kastler, Charles H Knowles, Paul A Lehur, Arantxa Muñoz-Duyos, Carlo Ratto, Mona B Rydningen, Michael Sørensen, Philip van Kerrebroeck, Stefan de Wachter
INTRODUCTION: Sacral neuromodulation (SNM) (sacral nerve stimulation SNS) has become an established therapy for functional disorders of the pelvic organs. Despite its overall success, the therapy fails in a proportion of patients. This may be partially due to inadequate electrode placement with suboptimal coupling of the electrode and nerve. Based on these assumptions the technique of sacral spinal neuromodulation has been redefined. All descriptions relate to the only currently available system licensed for all pelvic indications (Medtronic Interstim(®) )...
October 4, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28973941/granulocyte-colony-stimulating-factor-g-csf-signaling-in-spinal-microglia-drives-visceral-sensitization-following-colitis
#16
Lilian Basso, Tamia K Lapointe, Mircea Iftinca, Candace Marsters, Morley D Hollenberg, Deborah M Kurrasch, Christophe Altier
Pain is a main symptom of inflammatory diseases and often persists beyond clinical remission. Although we have a good understanding of the mechanisms of sensitization at the periphery during inflammation, little is known about the mediators that drive central sensitization. Recent reports have identified hematopoietic colony-stimulating factors as important regulators of tumor- and nerve injury-associated pain. Using a mouse model of colitis, we identify the proinflammatory cytokine granulocyte-colony-stimulating factor (G-CSF or Csf-3) as a key mediator of visceral sensitization...
October 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28973581/establishing-minimal-clinically-important-difference-of-spinal-cord-stimulation-therapy-in-post-laminectomy-syndrome
#17
Alexandra R Paul, Vignessh Kumar, Steven Roth, M Reid Gooch, Julie G Pilitsis
BACKGROUND: The concept of minimum clinically important difference (MCID) has been shown to be effective in spine surgery to differentiate between clinically insignificant and significant improvements as determined by the patient. OBJECTIVE: The MCID for spinal cord stimulation (SCS) to date has not been established. We sought to determine the MCID for SCS therapy for failed laminectomy syndromes. METHODS: Preoperative and 6-mo outcomes were assessed prospectively, including the Oswestry Disability Index (ODI), Beck Depression Inventory (BDI), and McGill and Visual Analog Survey questionnaires...
June 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28972143/shedding-of-membrane-associated-ldl-receptor-related-protein-1-from-microglia-amplifies-and-sustains-neuro-inflammation
#18
Coralie Brifault, Andrew S Gilder, Emilia Laudati, Michael Banki, Steven L Gonias
In the CNS, microglia are activated in response to injury or infection and in neurodegenerative diseases. The endocytic and cell-signaling receptor, LDL receptor-related protein-1 (LRP1), is reported to suppress innate immunity in macrophages and oppose microglial activation. The goal of this study was to identify novel mechanisms by which LRP1 may regulate microglial activation. Using primary cultures of microglia isolated from mouse brains, we demonstrated that LRP1 gene-silencing increases expression of pro-inflammatory mediators; however, the observed response was modest...
September 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28970100/early-intensive-hand-rehabilitation-is-not-more-effective-than-usual-care-plus-one-to-one-hand-therapy-in-people-with-sub-acute-spinal-cord-injury-hands-on-a-randomised-trial
#19
Lisa A Harvey, Sarah A Dunlop, Leonid Churilov, Mary P Galea
QUESTION: What is the effect of adding an intensive task-specific hand-training program involving functional electrical stimulation to a combination of usual care plus three 15-minute sessions per week of one-to-one hand therapy in people with sub-acute tetraplegia? DESIGN: A parallel group, randomised, controlled trial. Participants were randomly assigned (1:1) via a computer-generated concealed block randomisation procedure to either a control or experimental intervention...
October 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28967294/an-autonomic-neuroprosthesis-non-invasive-electrical-spinal-cord-stimulation-restores-autonomic-cardiovascular-function-in-individuals-with-spinal-cord-injury
#20
Aaron A Phillips, Jordan W Squair, Dimitry Sayenko, Victor Reggie Edgerton, Yury Gerasimenko, Andrei V Krassioukov
Despite autonomic dysfunction after spinal cord injury being the major cause of death and top health priority, the clinical management options for these conditions are limited to drugs with delayed onset and non-pharmacological interventions with equivocal effectiveness. We tested the capacity of electrical stimulation, applied transcutaneously over the spinal cord, to manage autonomic dysfunction in the form of orthostatic hypotension after spinal cord injury. We assessed beat-by-beat blood pressure (BP), stroke volume and cardiac contractility (dP/dt; Finometer), as well as cerebral blood flow (transcranial Doppler) in five individuals with motor complete spinal cord injury (four cervical, one thoracic) during an orthostatic challenge with and without transcutaneous electrical stimulation applied at the TVII level...
October 1, 2017: Journal of Neurotrauma
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