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https://read.qxmd.com/read/38333680/pregnancy-associated-anti-tif1-dermatomyositis-responsive-to-intravenous-immunoglobulin
#1
Jason Kieffer, Chenan Andy Huang, William Steffes
No abstract text is available yet for this article.
March 2024: JAAD Case Reports
https://read.qxmd.com/read/38317519/the-impact-of-hormones-in-autoimmune-cutaneous-diseases
#2
REVIEW
Lais Lopes Almeida Gomes, Adrienne J Werth, Preethi Thomas, Victoria P Werth
INTRODUCTION: Dermatomyositis, systemic and cutaneous lupus erythematosus have a significantly higher prevalence in women than men, emphasizing the relevance of exploring the relationship between sex hormones and autoimmune skin diseases. This review analyzes the interplay between sex hormones and these two skin diseases. MATERIALS AND METHODS: We performed an extensive literature search using the PubMed database from July to August 2023. Search terms included 'contraceptives', 'pregnancy', 'hormone replacement', 'tamoxifen', and 'aromatase inhibitors'...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38235694/neutrophilic-dermatoses-as-a-manifestation-of-a-systemic-lupus-erythematosus-flare
#3
JOURNAL ARTICLE
Yingxue Wang, Eugenia Chen, Priyanka Iyer
Neutrophilic dermatoses (NDs) refer to a group of cutaneous conditions histologically characterized by the dense accumulation of neutrophils in the skin in the absence of infection. NDs have been associated with underlying autoimmune connective tissue disorders (CTDs) such as systemic lupus erythematosus (SLE), Sjogren's syndrome, and dermatomyositis. We describe a case of neutrophilic dermatoses as a manifestation of a SLE flare.
January 18, 2024: Lupus
https://read.qxmd.com/read/38222766/mixed-connective-tissue-and-ovarian-cancer-a-case-report
#4
Maysoun Kudsi, Naram Khalayli, Leen Hola, Maria Aldeeb, Aghiad Aziz
BACKGROUND: Mixed connective tissue disease (MCTD) is characterized by high titres of distinct antibodies: U1 ribonucleoprotein with variable clinical features seen in rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis, and dermatomyositis. Limited case reports revealed the association between MCTD and cancer, like lymphoma, lung cancers, and others. CASE PRESENTATION: A 22-year-old female presented with enlargement of the abdomen and oedema of the lower extremities, gradually started 25 days The patient had been diagnosed to have rheumatoid arthritis...
January 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/37972926/patients-with-autoimmune-skin-diseases-are-at-increased-risk-of-adverse-pregnancy-outcomes
#5
JOURNAL ARTICLE
Heejo Keum, Bonnie Bermas, Shivani Patel, Heidi T Jacobe, Benjamin F Chong
BACKGROUND: Increased rates of adverse pregnancy outcomes have been reported in association with rheumatologic diseases such as systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis. However, little is known about pregnancy outcomes in patients with autoimmune skin diseases. OBJECTIVE: This study aimed to determine the frequency of adverse pregnancy outcomes in patients with autoimmune skin diseases. We hypothesized that similar to rheumatic diseases, the rate of adverse pregnancy outcomes in patients with autoimmune skin diseases would be higher than the general population...
January 2024: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/37026900/pregnancy-course-and-outcomes-of-patients-with-polymyositis-and-dermatomyositis-pm-dm-managed-in-a-single-center
#6
JOURNAL ARTICLE
Rina Mino, Hiromi Shimada, Risa Wakiya, Shusaku Nakashima, Taichi Miyagi, Koichi Sugihara, Yusuke Ushio, Mao Mizusaki, Kanako Chujo, Tomohiro Kameda, Kenji Kanenishi, Norimitsu Kadowaki, Hiroaki Dobashi
We aimed to determine the association between disease activity during pregnancy and pregnancy outcomes of women with polymyositis and dermatomyositis (PM/DM). Patients with PM/DM who were managed from pregnancy to delivery at Kagawa University Hospital from March 2006 to May 2021 were enrolled. Clinical data were retrospectively analyzed to evaluate the association between disease activity during pregnancy and pregnancy outcomes. Eight pregnancies in 5 women with PM/DM were analyzed. The mean age at conception was 28...
April 7, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/36828636/new-onset-mda-5-positive-dermatomyositis-and-massive-perivillous-fibrin-deposition-in-third-trimester-of-pregnancy-a-case-report
#7
Charlotte Krones, Mi Vu, Benjamin Popp, Laura Scardamaglia
We report a case of a 42-year-old woman (Gravida 1, Para 1) who presented in her third trimester of pregnancy with a photo distributed eruption and arthralgias and was subsequently diagnosed with dermatomyositis. She had an emergency Caesarean section at 34 weeks plus 6 days gestation due to decreased fetal movements and non-reassuring fetal heart rate. Her placenta was sent for histopathology and showed features of massive perivillous fibrin deposition. To our knowledge, this is the first case of MDA-5 positive dermatomyositis in pregnancy with a live delivery...
February 24, 2023: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/36683783/immunosuppressive-therapy-before-and-during-pregnancy-may-improve-obstetric-outcomes-in-pregnancy-complicated-by-dermatomyositis-with-anti-mda-5-antibody-positivity-a-case-report
#8
Hiroyuki Goto, Kimito Kawahata, Akiko Shida, Saeko Nakagane, Hitoshi Isohata, Yu Yamazaki, Yoshihiro Yoshimura, Kyoko Hattori, Kazuki Sekiguchi, Ryuzo Ishikawa, Yoko Onishi, Yuji Kanai, Nobuya Unno, Daigo Ochiai
Dermatomyositis (DM) is one of the most common autoimmune rheumatic diseases affecting women of childbearing age. Pregnancy may lead to exacerbation of DM, especially of DM with anti-melanoma differentiation-associated gene (MDA) 5 antibody positivity, leading to a poor obstetric outcome. Here, we report consecutive pregnancies complicated by DM with anti-MDA-5 antibodies. A 32-year-old pregnant woman, gravida 3 para 1, presented with fetal growth restriction. Emergency cesarean section was performed because of non-reassuring fetal status at 28 weeks of gestation...
March 2023: Case Reports in Women's Health
https://read.qxmd.com/read/35867856/pregnancy-in-adult-onset-dermatomyositis-polymyositis-a-systematic-review
#9
REVIEW
Keyun Tang, Jia Zhou, Yining Lan, Hanlin Zhang, Hongzhong Jin
BACKGROUND: Idiopathic inflammatory myopathy (IIM) in pregnancy is uncommon but may result in complications for both mother and the fetus. AIM: In this systematic review, we summarized the current literature investigating outcomes of pregnancy related to the dermatomyositis/polymyositis (DM/PM) process. CONTENT: We searched PubMed, Embase, Cochrane Library, and Web of Science databases and included 61 studies reporting the disease course, pregnancy outcomes, and management of both pregnancy and DM/PM in the final analysis...
November 2022: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/35691682/severe-paraneoplastic-dermatomyositis-in-a-patient-with-high-grade-serous-ovarian-cancer
#10
Catherine Lajoie, Claudèle Brault, Suzanne Fortin, Lara de Guerke, Marie-Hélène Auclair
BACKGROUND: Paraneoplastic dermatomyositis following a diagnosis of ovarian cancer is rare. There are very few cases reported on the management of severe forms. CASE: We report the case of a 50-year-old woman diagnosed with stage IIIC high-grade serous ovarian cancer and a severe form of paraneoplastic dermatomyositis requiring mechanical ventilation. She had significant comorbidities further adding to the complexity of the chemotherapy regimen. Intravenous immunoglobulin and corticosteroids were also administered...
June 2022: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/34998078/the-effects-of-autoimmune-rheumatic-related-diseases-on-male-reproductive-health-a-systematic-review
#11
REVIEW
Soumaya Boussaid, Yasmine Makhlouf, Sonia Rekik, Samia Jammali, Elhem Cheour, Hela Sahli, Mohamed Elleuch, Helmi Ben Saad
Autoimmune rheumatic-related diseases (ARRDs) have physical and psychological impact on patients, including their sexual life. While many studies have investigated fertility problems in females, data on males-related fertility are scarce, which explains the lack of guidance. The main objective of this systematic review was to evaluate the reproductive health in males with ARRDs. This systematic review followed the preferred reporting items for systematic reviews guidelines. Original articles from Pubmed and Scopus, published until September 16, 2021, and tackling the effects of ARRDs and/or ARRDs treatments on male fertility and/or pregnancy outcomes, were included...
March 2022: Journal of Reproductive Immunology
https://read.qxmd.com/read/34394721/diagnosis-of-amyopathic-dermatomyositis-after-two-intrauterine-fetal-deaths
#12
M Alonso-Espías, N Martínez-Sánchez, A Robles-Marhuenda, M E Martín-Boado, R M Regojo-Zapata, J L Bartha
Chronic histiocytic intervillositis (CHIV) is an uncommon condition, characterized by an infiltrate of mononuclear cells of maternal origin in the intervillous space that has been related to placenta insufficiency and poor perinatal outcomes. The aetiology is unclear, although maternal immunological aggression toward fetal tissues has been proposed. Dermatomyositis (DM) is a multisystem autoimmune inflammatory myopathy. Different autoantibodies have been associated with particular clinical phenotypes; presence of anti-melanoma differentiation-associated gen 5 (MDA5) antibody has been associated with rapidly progressive interstitial lung disease and severe skin lesions, none of which the woman had...
June 2021: Obstetric Medicine
https://read.qxmd.com/read/34334572/clinical-and-serological-features-and-pregnancy-outcomes-in-women-with-polymyositis-dermatomyositis-a-case-based-review
#13
JOURNAL ARTICLE
Yuhei Ito, Yoshiki Yamamoto, Yasuo Suzuki, Kentaro Noda, Ayako Nakajima
We encountered a 30-year-old woman who developed dermatomyositis during pregnancy and was positive for anti-Mi-2 antibodies. She was successfully treated with prednisolone and tacrolimus and delivered a healthy child. We reviewed the cases of idiopathic inflammatory myositis (IIM) that developed during pregnancy that were published after the year 2000 to elucidate the profile of myositis-specific antibodies (MSAs) in them and to evaluate their obstetric outcomes. In cases with IIM that developed during pregnancy, anti-Mi-2, anti-TIF1-g, anti-Jo-1, and anti-EJ antibodies was detected in one case each...
January 15, 2022: Internal Medicine
https://read.qxmd.com/read/33837447/association-of-various-myositis-specific-autoantibodies-with-dermatomyositis-and-polymyositis-triggered-by-pregnancy
#14
REVIEW
Chikaho Akiyama, Tsuyoshi Shirai, Hiroko Sato, Hiroshi Fujii, Tomonori Ishii, Hideo Harigae
Although pregnancy is an important risk factor for autoimmune rheumatic diseases, little is known regarding the association between pregnancy and dermatomyositis (DM) or polymyositis (PM). Herein, we present two patients with DM that developed during the perinatal period. The first patient was positive for anti-aminoacyl synthetase (ARS) antibody and developed DM in the 14th week of pregnancy. Despite treatment, her foetus died of intrauterine growth restriction in the 27th week. The second patient was positive for anti-melanoma differentiation-associated gene 5 (MDA-5) antibody and developed DM 1 week after miscarriage at 9 weeks of gestation...
July 2022: Rheumatology International
https://read.qxmd.com/read/33717138/case-report-rapidly-progressive-interstitial-lung-disease-in-a-pregnant-patient-with-anti-melanoma-differentiation-associated-gene-5-antibody-positive-dermatomyositis
#15
Cuihong Chen, Yulan Chen, Qin Huang, Qiu Hu, Xiaoping Hong
Dermatomyositis occurs extremely rarely during pregnancy. A number of studies in the published literature have documented how the outcome of pregnancy is poor for both mother and fetus. The present case study reports on a patient who was diagnosed with clinically amyopathic dermatomyositis complicated by interstitial lung disease during pregnancy, and was successfully treated with a combined immunosuppressant regimen. To the best of the authors' knowledge, this is the first case study detailing how a pregnant woman with clinically amyopathic dermatomyositis with positive anti-melanoma differentiation-associated gene 5 antibody achieved complete remission after early intervention of combined immunosuppressive therapy without residual pulmonary interstitial changes...
2021: Frontiers in Immunology
https://read.qxmd.com/read/32732613/outcomes-of-pregnancy-in-women-with-inflammatory-myositis-a-cohort-study-from-india
#16
JOURNAL ARTICLE
Latika Gupta, Abhishek Zanwar, Sakir Ahmed, Amita Aggarwal
OBJECTIVES: Idiopathic inflammatory myositis (IIM) commonly affects women in the childbearing age group. Both disease activity and immunosuppressants used may have adverse effects on fertility and outcomes of pregnancy. We explored these outcomes in a cohort of women with IIM. METHODS: Women 18 years or older with IIM (Bohan and Peter criteria) were interviewed for demography, menstrual status, history of conception, outcomes, and disease features. Comparisons were drawn between pregnancies occurring before and after onset of disease...
August 2020: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/32222877/jak-inhibitors-prospects-in-connective-tissue-diseases
#17
REVIEW
Hanxiao You, Dong Xu, Jiuliang Zhao, Jing Li, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng
The dysregulation of the JAK-STAT pathway is associated with various immune disorders. Four JAK inhibitors have been approved for rheumatoid arthritis (RA), and numerous JAK inhibitors are currently being tested in phase II and III trials for the treatment of various autoimmune inflammatory diseases. In this narrative review, we elucidate the involvement of the JAK-STAT signaling pathway in the pathogenesis of connective tissue diseases (CTDs). We also discuss the efficacy of the first- and second-generation JAK inhibitors (tofacitinib, baricitinib, ruxolitinib, peficitinib, filgotinib, upadacitinib, solcitinib, itacitinib, decernotinib, R333, and pf-06651600) for CTDs including RA, systemic lupus erythematosus, dermatomyositis, systemic sclerosis, Sjögren's syndrome, and vasculitis, based on laboratory and clinical research findings...
December 2020: Clinical Reviews in Allergy & Immunology
https://read.qxmd.com/read/31665457/pregnancy-triggers-the-onset-of-anti-transcriptional-intermediary-factor-1%C3%AE-antibody-positive-dermatomyositis-a-case-series
#18
LETTER
Kazumasa Oya, Sae Inoue, Akimasa Saito, Yoshiyuki Nakamura, Yosuke Ishitsuka, Yasuhiro Fujisawa, Rei Watanabe, Shijima Taguchi, Manabu Fujimoto, Naoko Okiyama
No abstract text is available yet for this article.
June 1, 2020: Rheumatology
https://read.qxmd.com/read/31571337/preterm-birth-phenotypes-in-women-with-autoimmune-rheumatic-diseases-a-population-based-cohort-study
#19
JOURNAL ARTICLE
K D Kolstad, J A Mayo, L Chung, Y Chaichian, V M Kelly, M Druzin, D K Stevenson, G M Shaw, J F Simard
OBJECTIVE: To investigate preterm birth (PTB) phenotypes in women with different autoimmune rheumatic diseases in a large population-based cohort. DESIGN: Retrospective cohort study. SETTING: California, USA. POPULATION: All live singleton births in California between 2007 and 2011 were analysed. Patients with autoimmune disease at delivery were identified by International Classification of Diseases, Ninth Revision , Clinical Modification (ICD-9-CM), codes for systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), polymyositis/dermatomyositis (DM/PM), and juvenile idiopathic arthritis (JIA)...
September 30, 2019: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/31379350/pregnancy-in-autoimmune-diseases-in-the-sub-saharan-zone-the-experience-of-the-university-hospital-of-libreville-department-of-internal-medicine
#20
JOURNAL ARTICLE
J Iba Ba, I Nseng Nseng Obiang, S Ntsame Ngoua, M Igala, U D Kombila, D Malekou Mwenpindi, M I Nziengui Madjinou, N O Cabrera, L Ledaga Letombo, J B Boguikouma
Autoimmune diseases are a group of heterogeneous conditions responsible for polymorphic clinical and biological manifestations. Because pregnancy activates them and promotes gestational complications, it is difficult for women with these diseases. Pregnancy and autoimmune diseases have rarely been studied in sub-Saharan Africa. We report the experience of the Internal Medicine Department of the University Hospital of Libreville. Conducted retrospectively for 2008 through 2011, and prospectively from 2012 through August 31, 2018, this descriptive and analytical study examined the records at the Department of Internal Medicine of the University Hospital Center of Libreville of women with a known autoimmune disease, receiving regular care there, and who became pregnant after the diagnosis...
May 1, 2019: Médecine et Santé Tropicales
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