Chenyuan Gong, Hongyan Mu, Jiaojiao Luo, Rujun Zhang, Dan Hu, Zhenhua Chen, Cheng Fang, Zhongxian Chen, Xinxue Zhu, Chao Yao, Lixin Wang, Yufu Zhou, Weimin Zhao, Shiguo Zhu
Immune evasion by cancer cells poses a significant challenge for natural killer (NK) cell-based immunotherapy. Pyroptosis, a newly discovered form of programmed cell death, has shown great potential for enhancing the antitumor immunity of NK cells. Consequently, targeting pyroptosis has become an attractive strategy for boosting NK cell activity against cancer. In this study, various assays were conducted, including NK cell cytotoxicity assays, flow cytometry, xenograft tumor models, real-time PCR, and ELISA to assess NK cell-mediated cell killing, as well as gene and protein expressions...
March 8, 2024: Journal of Leukocyte Biology