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Mycobacterium haemophilum

Shradha Subedi, Fanrong Kong, Peter Jelfs, Timothy J Gray, Meng Xiao, Vitali Sintchenko, Sharon C-A Chen
Accurate identification of slowly growing nontuberculous mycobacteria (SG-NTM) of clinical significance remains problematic. This study evaluated a novel method of SG-NTM identification by amplification of the mycobacterial 16S-23S rRNA internal transcribed spacer (ITS) region followed by resolution of amplified fragments by sequencer-based capillary gel electrophoresis (SCGE). Fourteen American Type Culture Collection (ATCC) strains and 103 clinical/environmental isolates (total n = 24 species) of SG-NTM were included...
2016: PloS One
Kyle Donnelly, Thomas B Waltzek, James F X Wellehan, Nicole I Stacy, Maria Chadam, Brian A Stacy
Mycobacteriosis is infrequently reported in free-ranging sea turtles. Nontuberculous Mycobacterium haemophilum was identified as the causative agent of disseminated mycobacteriosis in a juvenile leatherback turtle (Dermochelys coriacea) that was found stranded on the Atlantic coast of Florida. Disseminated granulomatous inflammation was identified histologically, most notably affecting the nervous system. Identification of mycobacterial infection was based on cytologic, molecular, histologic, and microbiologic methods...
November 2016: Journal of Veterinary Diagnostic Investigation
Jean-Philippe Mocho
Considering the numbers of zebrafish held in the laboratories, it is relevant to develop some tools to monitor the health of the animals, as well as their biotope. Environmental samples can be used to detect aquatic pathogens. Comprehensive health monitoring would thus seek pathogens in three dimensions of the animals and microbes' habitat: the fish, the sludge, and the water. This three-dimensional approach is called the 3D screen and it introduces some complementary tools to routine sentinel screening. For example, sludge and sump swabs analyses allow an efficient detection of pathogens at a low cost and with a fast turnover...
July 2016: Zebrafish
Jerome A Lindeboom
BACKGROUND: Nontuberculous mycobacteria rarely cause facial skin lesions in immunocompetent children. AIM: I describe the clinical features and treatment of nontuberculous mycobacteria facial lesions. MATERIALS AND METHODS: The diagnosis of a facial nontuberculous mycobacteria infection was established using polymerase chain reaction. RESULTS: Of 286 children with confirmed nontuberculous mycobacteria infection, 14 (4...
March 2016: Pediatric Dermatology
JoAnn M Tufariello, Christopher A Kerantzas, Catherine Vilchèze, R Brent Calder, Eric K Nordberg, Jack A Fischer, Travis E Hartman, Eva Yang, Timothy Driscoll, Laura E Cole, Robert Sebra, Shahina B Maqbool, Alice R Wattam, William R Jacobs
UNLABELLED: Mycobacterium haemophilum is an emerging pathogen associated with a variety of clinical syndromes, most commonly skin infections in immunocompromised individuals. M. haemophilum exhibits a unique requirement for iron supplementation to support its growth in culture, but the basis for this property and how it may shape pathogenesis is unclear. Using a combination of Illumina, PacBio, and Sanger sequencing, the complete genome sequence of M. haemophilum was determined. Guided by this sequence, experiments were performed to define the basis for the unique growth requirements of M...
November 17, 2015: MBio
Adeel S Zubair, Daniel K Rogstad, Mary J Kasten
No abstract text is available yet for this article.
August 2015: Minnesota Medicine
O Otome, M O'Reilly, L Lim
Disseminated non-tuberculous mycobacterial (NTM) infection is rare in immunocompetent adults. Anti-interferon-gamma (IFN-γ) autoantibodies have recently been associated with NTM infections, particularly in patients of Asian ethnicity. We describe a case of disseminated Mycobacterium haemophilum skeletal infection due to anti IFN-γ autoantibodies in a 71-year-old Cambodian man. He responded to a combination of anti-mycobacterial antibiotics without requirement for immunomodulator therapy. Testing for acquired IFN-γ deficiency due to IFN-γ autoantibodies should be considered when standard tests for immunodeficiency are negative in patients with unusual or severe opportunistic infections, including NTM...
October 2015: Internal Medicine Journal
Wai Sze Agnes Chan, Shang-Ian Tee, Nisha Su Yien Chandran, Jiun Yit Pan
Non-tuberculous mycobacteria (NTM) are a group of environmental pathogens, which cause a broad spectrum of disease. The incidence of NTM infection is increasing, especially in immunocompromized patients. The past three decades also saw a rapid increase in the incidence of NTM infection involving otherwise healthy subjects. We report a case of cutaneous NTM infection in a 79-year-old Chinese woman, who was receiving methotrexate for psoriasis. Mycobacterial culture grew Mycobacterium abscessus, and the lesions cleared with a combination of oral clarithromycin, ciprofloxacin and doxycycline...
May 21, 2015: Dermatology Reports
Kentaro Ishii, Norihisa Ishii, Kazue Nakanaga, Kazuaki Nakano, Ikuo Saito, Akihiko Asahina
Mycobacterium haemophilum is a slow-growing non-tuberculous mycobacterium that is rarely known to cause human skin infection, particularly in immunocompromised patients. We recently experienced a 69-year-old Japanese woman with this infection who had been under immunosuppressive treatment for recalcitrant rheumatoid arthritis. The patient showed disseminated erythematous plaques and subcutaneous nodules on the face and extremities, and interestingly, the face manifested with a striking "facies leontina" appearance...
October 2015: Journal of Dermatology
Luke K Barr, Leroy R Sharer, Erina Khadka Kunwar, Rajendra Kapila, Sherif R Zaki, Clifton P Drew, Julu Bhatnagar, James K Liu, Debra Chew
We report a rare case of Mycobacterium haemophilum presenting as an intraventricular granulomatous mass with loculated hydrocephalus and seizures in a patient with human immunodeficiency virus. M. haemophilum, a slow-growing mycobacteria, causes localized and disseminated disease among immunocompromised hosts. Central nervous system infection with M. haemophilum is extremely rare. Preoperative laboratory testing of our patient for tuberculosis, toxoplasmosis, sarcoidosis and histoplasmosis were negative. Surgical resection of the mass revealed a caseating granuloma that stained positive for acid-fast bacillus suggesting possible tuberculoma...
June 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Nadia Atiya, Helmi Sulaiman, Jennifer Chong, Kee Peng Ng
We report the first case of an immunocompromised adult patient presenting with cervicofacial lymphadenitis due to Mycobacterium haemophilum, confirmed using hsp65 gene sequencing and line-probe assays. In resource-limited settings, especially in developing countries, appropriate culture methods and rapid molecular diagnostic tools such as hsp65 gene sequencing for identification of this organism may not be readily available. This may cause M. haemophilum infections to go unrecognised or lead to delays in diagnosis...
March 2015: Journal of Infection in Developing Countries
Wei Gao, Hao Chen, Hongsheng Wang, Haiqing Jiang, Weijun Liu, Danfeng Hao, Meiyu Tang
No abstract text is available yet for this article.
July 2015: Acta Dermato-venereologica
Sarah J Woodhouse, Scott D Fitzgerald, Ailam Lim, Steven R Bolin
A sub-adult male Assam trinket snake (Elaphe frenata) that was confiscated from an exotic animal dealer was found dead in its enclosure after a 17-mo quarantine. The snake had grown well during that period and had no physical examination or bloodwork abnormalities during the quarantine. On gross necropsy, masses were found in the epaxial musculature and stomach, the lung was diffusely thickened, the ventricular wall was mottled, and there was intracoelomic and pericardial effusion. Histopathology revealed diffusely disseminated granulomatous infiltrates throughout the lung interstitium and multifocal granulomatous infiltrates in the transmural gastric mass, within the myocardium and pericardial adipose tissue, in the liver and kidney parenchyma, in the cervical region surrounding the trachea and thyroid, and replacing the myofibers of the craniolateral epaxial muscles...
December 2014: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Gail B Cross, Quynh Le, Brooke Webb, Grant A Jenkin, Tony M Korman, Michelle Francis, Ian Woolley
We report a case of disseminated Mycobacterium haemophilum osteomyelitis in a patient with advanced HIV infection, who later developed recurrent immune reconstitution inflammatory syndrome after commencement of antiretroviral therapy. We review previous reports of M. haemophilum bone and joint infection associated with HIV infection and describe the management of M. haemophilum-associated immune reconstitution inflammatory syndrome, including the role of surgery as an adjunctive treatment modality and the potential drug interactions between antiretroviral and antimycobacterial agents...
November 2015: International Journal of STD & AIDS
Choon Chiat Oh, Shiu Ming Pang, Inny Busmanis, Shichao Sun, Li-Hwei Sng
No abstract text is available yet for this article.
September 2014: International Journal of Dermatology
Alexander E Merkler, George Parlitsis, Sarju Patel, Cristiano Oliveira, Ehud Lavi, Audrey Schuetz, Alison May, Dara Bier, Sara Simpson, Szilard Kiss, Marc Dinkin
No abstract text is available yet for this article.
August 12, 2014: Neurology
Julie Sogani, Jana Ivanidze, C Douglas Phillips
We report a case of chiasmitis caused by a rare nontuberculous mycobacterium in an immunocompromised patient. A 44-year-old man with a history of AIDS presented with recurrent vision loss and headache. Magnetic resonance imaging (MRI) demonstrated an enhancing mass involving the optic chiasm. Histopathologic and microbiological evaluation revealed infection with Mycobacterium haemophilum. While combination antimicrobial and steroid therapy contributed to improvement in his vision, the patient's symptoms recurred...
September 2014: Clinical Imaging
Aubonphan Buppajarntham, Anucha Apisarnthanarak, Sasinuj Rutjanawech, Thana Khawcharoenporn
Mycobacterium haemophilum is an environmental organism that rarely causes infections in humans. We report a patient with acquired immunodeficiency syndrome who had central nervous system infection due to M. haemophilum. The diagnosis required brain tissue procurement and molecular identification method while the treatment outcome was unfavourable.
March 2015: International Journal of STD & AIDS
T Doherty, M Lynn, A Cavazza, E Sames, R Hughes
A 66-year-old woman presented with pustular lesions of her face, trunk, and limbs and an acute arthritis of the knees and elbows. She had a complex medical background and had been on immunosuppressants for three years after a liver transplant. Tissue samples from her skin lesions and synovial fluid showed acid-fast bacilli. Mycobacterium haemophilum, an atypical mycobacteria, was later grown on culture. During her treatment with combination antibiotic therapy, she developed a pronounced generalised lymphadenopathy...
2014: Case Reports in Rheumatology
Kathryn Ducharlet, Caitlin Murphy, Sven-Jean Tan, Karen M Dwyer, David Goodman, Craig Aboltins, John R Daffy, Robyn G Langham
Mycobacterium haemophilum is a rare isolate of non-tuberculous Mycobacterium which has been reported to affect immunocompromised patients. We report a case of a 32-year-old renal transplant patient with M.  haemophilum infection initially involving his left sinus which was treated with appropriate antimicrobial therapy for thirteen months. Two weeks after cessation of antibiotics the infection rapidly recurred in his skin and soft tissues of his hands and feet. This case highlights the difficult diagnostic and therapeutic implications of atypical infections in transplant patients...
April 2014: Nephrology
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