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Mycobacterium haemophilum

U Anandh, K Jayanna
A 71-year-old male, a renal allograft recipient, presented to us with a history of fever and right palm swelling. He had a history of fever 7 years back when he was treated with antitubercular treatment (ATT). Three years back, he was diagnosed to have gout and he was started on allopurinol. He developed severe bone marrow toxicity and allopurinol was changed to febuxostat. On admission, routine investigations did not reveal any focus of infection. The fluid aspirate from the palm revealed acid-fast bacilli (AFB)...
November 2017: Indian Journal of Nephrology
Shinji Takeyari, Yoshiko Hashii, Hisao Yoshida, Shigetoyo Kogaki, Keiichi Ozono
No abstract text is available yet for this article.
December 4, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
S Willemse, M Oomens, L Karssemakers, J de Lange
BACKGROUND: The differential diagnosis in a child with a swelling in the neck is broad. Chronic lymphadenopathy in children quite often leads to extensive blood tests. Cervicofacial non-tuberculous mycobacterial (NTM) lymphadenitis is, however, not revealed by blood tests. It is a rare condition, which is mostly seen in young children. CASE DESCRIPTION: A 4-year-old girl had a 9-week history of a swelling in her neck; the skin covering the swelling had been red and flaking for the past week...
2017: Nederlands Tijdschrift Voor Geneeskunde
Michael H Woodworth, Carina Marquez, Henry Chambers, Anne Luetkemeyer
No abstract text is available yet for this article.
2017: Open Forum Infectious Diseases
Rika Nishikawa, Yozo Yamada, Haruhisa Kanki, Hiroshi Matsuoka, Tatsuya Nakamura, Takumi Jikimoto, Mari Kusuki, Norihisa Ishii, Kenichiro Ohnuma, Kazue Nakanaga, Chikako Nishigori
Mycobacterium haemophilum is a slow-growing, non-tuberculous mycobacteria that causes cutaneous infection. We describe a case of cutaneous infection in a 68-year-old Japanese man with polymyositis. This was caused by M. haemophilum harboring one base insertion in gene sequence. At first, the causal microorganism was misidentified as M. intracellulare by COBAS(®) TaqMan(®) MAI test. However, poor growth on Ogawa media and growth enhancement on 7H11C agar around a hemin-containing disk prompted us to reinvestigate the causal microorganisms, which were revealed to be M...
August 3, 2017: Journal of Dermatology
Gary W Procop
The importance of mycobacteria as opportunistic pathogens, particularly members of the M. avium complex (MAC), in patients with progressive HIV infection was recognized early in the AIDS epidemic. It took longer to appreciate the global impact and devastation that would result from the deadly synergy that exists between HIV and M. tuberculosis. This HIV/M. tuberculosis co-pandemic is ongoing and claiming millions of lives every year. In addition to MAC, a number of other non-tuberculous mycobacteria have been recognized as opportunistic pathogens in HIV-infected individuals; some of these are more commonly encountered (e...
July 2017: Seminars in Diagnostic Pathology
Danielle M Meritet, Donna M Mulrooney, Michael L Kent, Christiane V Löhr
Mycobacterium spp. infections are common in zebrafish kept in research facilities. These comorbidities can substantially modulate the responses of these fish to external and internal stimuli. Therefore, diagnostic tests to detect Mycobacterium spp. infections in zebrafish colonies prove essential. Here, we outline the development of quantitative simplex real-time PCR assays to detect the 3 Mycobacterium species most commonly identified in laboratory zebrafish. The assays targeted the heatshock protein 65 gene of M...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
Danielle M Meritet Donna M Mulrooney Michael L Kent And Christiane V Löhr
Mycobacterium spp. infections are common in zebrafish kept in research facilities. These comorbidities can substantiallymodulate the responses of these fish to external and internal stimuli. Therefore, diagnostic tests to detect Mycobacterium spp.infections in zebrafish colonies prove essential. Here, we outline the development of quantitative simplex real-time PCRassays to detect the 3 Mycobacterium species most commonly identified in laboratory zebrafish. The assays targeted the heatshock protein 65 gene of M...
February 9, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
Shahram Sabeti, Mahsa Pourabdollah Tootkaboni, Mitra Abdolahi, Mihan Pourabdollah
INTRODUCTION: Mycobacterium haemophilum is a slow-growing nontuberculous mycobacterium (NTM) that can cause ulcerating cutaneous or subcutaneous nodular skin lesions in immunocompromised and immunocompetent patients. Acid-fast staining cannot distinguish NTM from M. tuberculosis; culturing at two temperatures with iron-supplemented media and polymerase chain reaction (PCR) are needed for optimal detection of M. haemophilum. CASE PRESENTATION: A 32-year-old man with end-stage renal disease, undergoing hemodialysis twice a week, presented with multiple, painless, nonpruritic nodular lesions...
December 2016: International Journal of Mycobacteriology
Silke R Brix, Christof Iking-Konert, Rolf A K Stahl, Ulrich Wenzel
Opportunistic infections are a major concern in renal and transplant medicine. We present the case of a renal transplant recipient with a generalised Mycobacterium haemophilum infection after an increase in immunosuppressive therapy and treatment with a tumour necrosis factor-α (TNF-α) inhibitor. Infection involved skin and soft tissue, joints and bones, as well as the renal transplant with an interstitial nephritis. Rapid diagnosis using PCR and DNA sequencing allowed early appropriate treatment. Triple antibiotic therapy and reduction in immunosuppression resulted in a slow but sustained recovery...
October 31, 2016: BMJ Case Reports
Aliyah Baluch, Yanina Pasikhova, Matthew Snyder
Nontuberculous mycobacterial infections can often occur in individuals with adequate immune function. Such infections typically have cutaneous involvement and are caused by rapidly growing mycobacterium. Other nontuberculous mycobacteria species, like Mycobacterium haemophilum, almost always present as opportunistic infections occurring in severely immunocompromised hosts. Here, we present a complicated and protracted course of diagnosing M. haemophilum lower extremity cutaneous infection in a matched-unrelated donor stem cell transplant recipient...
February 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Shradha Subedi, Fanrong Kong, Peter Jelfs, Timothy J Gray, Meng Xiao, Vitali Sintchenko, Sharon C-A Chen
Accurate identification of slowly growing nontuberculous mycobacteria (SG-NTM) of clinical significance remains problematic. This study evaluated a novel method of SG-NTM identification by amplification of the mycobacterial 16S-23S rRNA internal transcribed spacer (ITS) region followed by resolution of amplified fragments by sequencer-based capillary gel electrophoresis (SCGE). Fourteen American Type Culture Collection (ATCC) strains and 103 clinical/environmental isolates (total n = 24 species) of SG-NTM were included...
2016: PloS One
Kyle Donnelly, Thomas B Waltzek, James F X Wellehan, Nicole I Stacy, Maria Chadam, Brian A Stacy
Mycobacteriosis is infrequently reported in free-ranging sea turtles. Nontuberculous Mycobacterium haemophilum was identified as the causative agent of disseminated mycobacteriosis in a juvenile leatherback turtle (Dermochelys coriacea) that was found stranded on the Atlantic coast of Florida. Disseminated granulomatous inflammation was identified histologically, most notably affecting the nervous system. Identification of mycobacterial infection was based on cytologic, molecular, histologic, and microbiologic methods...
November 2016: Journal of Veterinary Diagnostic Investigation
Jean-Philippe Mocho
Considering the numbers of zebrafish held in the laboratories, it is relevant to develop some tools to monitor the health of the animals, as well as their biotope. Environmental samples can be used to detect aquatic pathogens. Comprehensive health monitoring would thus seek pathogens in three dimensions of the animals and microbes' habitat: the fish, the sludge, and the water. This three-dimensional approach is called the 3D screen and it introduces some complementary tools to routine sentinel screening. For example, sludge and sump swabs analyses allow an efficient detection of pathogens at a low cost and with a fast turnover...
July 2016: Zebrafish
Jerome A Lindeboom
BACKGROUND: Nontuberculous mycobacteria rarely cause facial skin lesions in immunocompetent children. AIM: I describe the clinical features and treatment of nontuberculous mycobacteria facial lesions. MATERIALS AND METHODS: The diagnosis of a facial nontuberculous mycobacteria infection was established using polymerase chain reaction. RESULTS: Of 286 children with confirmed nontuberculous mycobacteria infection, 14 (4...
March 2016: Pediatric Dermatology
JoAnn M Tufariello, Christopher A Kerantzas, Catherine Vilchèze, R Brent Calder, Eric K Nordberg, Jack A Fischer, Travis E Hartman, Eva Yang, Timothy Driscoll, Laura E Cole, Robert Sebra, Shahina B Maqbool, Alice R Wattam, William R Jacobs
UNLABELLED: Mycobacterium haemophilum is an emerging pathogen associated with a variety of clinical syndromes, most commonly skin infections in immunocompromised individuals. M. haemophilum exhibits a unique requirement for iron supplementation to support its growth in culture, but the basis for this property and how it may shape pathogenesis is unclear. Using a combination of Illumina, PacBio, and Sanger sequencing, the complete genome sequence of M. haemophilum was determined. Guided by this sequence, experiments were performed to define the basis for the unique growth requirements of M...
November 17, 2015: MBio
Adeel S Zubair, Daniel K Rogstad, Mary J Kasten
No abstract text is available yet for this article.
August 2015: Minnesota Medicine
O Otome, M O'Reilly, L Lim
Disseminated non-tuberculous mycobacterial (NTM) infection is rare in immunocompetent adults. Anti-interferon-gamma (IFN-γ) autoantibodies have recently been associated with NTM infections, particularly in patients of Asian ethnicity. We describe a case of disseminated Mycobacterium haemophilum skeletal infection due to anti IFN-γ autoantibodies in a 71-year-old Cambodian man. He responded to a combination of anti-mycobacterial antibiotics without requirement for immunomodulator therapy. Testing for acquired IFN-γ deficiency due to IFN-γ autoantibodies should be considered when standard tests for immunodeficiency are negative in patients with unusual or severe opportunistic infections, including NTM...
October 2015: Internal Medicine Journal
Wai Sze Agnes Chan, Shang-Ian Tee, Nisha Su Yien Chandran, Jiun Yit Pan
Non-tuberculous mycobacteria (NTM) are a group of environmental pathogens, which cause a broad spectrum of disease. The incidence of NTM infection is increasing, especially in immunocompromized patients. The past three decades also saw a rapid increase in the incidence of NTM infection involving otherwise healthy subjects. We report a case of cutaneous NTM infection in a 79-year-old Chinese woman, who was receiving methotrexate for psoriasis. Mycobacterial culture grew Mycobacterium abscessus, and the lesions cleared with a combination of oral clarithromycin, ciprofloxacin and doxycycline...
May 21, 2015: Dermatology Reports
Kentaro Ishii, Norihisa Ishii, Kazue Nakanaga, Kazuaki Nakano, Ikuo Saito, Akihiko Asahina
Mycobacterium haemophilum is a slow-growing non-tuberculous mycobacterium that is rarely known to cause human skin infection, particularly in immunocompromised patients. We recently experienced a 69-year-old Japanese woman with this infection who had been under immunosuppressive treatment for recalcitrant rheumatoid arthritis. The patient showed disseminated erythematous plaques and subcutaneous nodules on the face and extremities, and interestingly, the face manifested with a striking "facies leontina" appearance...
October 2015: Journal of Dermatology
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