keyword
MENU ▼
Read by QxMD icon Read
search

astaxanthin, clinical trial

keyword
https://www.readbyqxmd.com/read/27834813/the-potential-of-non-provitamin-a-carotenoids-for-the-prevention-and-treatment-of-non-alcoholic-fatty-liver-disease
#1
REVIEW
Ana Gabriela Murillo, Diana M DiMarco, Maria Luz Fernandez
Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated spectrum of comorbidities defined by the presence of metabolic dysfunction, oxidative stress, inflammation, and fibrosis in the liver. If left untreated, NAFLD can progress to cirrhosis, liver failure, or hepatocellular carcinoma. NAFLD is recognized as the most common liver disease in the United States, affecting around 30% of the population. Identification of dietary components capable of reducing or preventing NAFLD is therefore essential to battle this condition...
November 8, 2016: Biology
https://www.readbyqxmd.com/read/27658618/astaxanthin-a-promising-protector-against-gentamicin-induced-nephrotoxicity-in-rats
#2
Yasser Omar, Naglaa Abd El Khalik Gobba, Mohammed Abdalla Hussein
Gentamicin is an aminoglycoside antibiotic widely used against infections caused by Gram-negative microorganisms. Nephrotoxicity is the main limitation to its therapeutic use. The objective of this study was to evaluate the potential protective effect of astaxanthin on the renal damage generated by gentamicin in rats, in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic applications. The daily oral administration of the astaxanthin at a concentration of 50 mg/kg for 15 days to gentamicin (80 mg/kg...
September 22, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27157250/the-effects-of-a-nutraceutical-combination-on-plasma-lipids-and-glucose-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
Matteo Pirro, Massimo Raffaele Mannarino, Vanessa Bianconi, Luis E Simental-Mendía, Francesco Bagaglia, Elmo Mannarino, Amirhossein Sahebkar
Dyslipidemia and hyperglycemia are associated with an increased risk of ischemic cardiovascular disease. Positive effects of a nutraceutical combination comprising red yeast rice, berberine, policosanol, astaxanthin, coenzyme Q10 and folic acid (NComb) on plasma lipid and glucose levels have been reported in some but not all clinical trials. To address this inconsistency, we tried to estimate the size of lipid- and glucose-lowering effects of NComb through a systematic review and meta-analysis of randomized controlled trials...
August 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26675778/astaxanthin-has-no-effect-on-arterial-stiffness-oxidative-stress-or-inflammation-in-renal-transplant-recipients-a-randomized-controlled-trial-the-xanthin-trial
#4
RANDOMIZED CONTROLLED TRIAL
Jeff S Coombes, James E Sharman, Robert G Fassett
BACKGROUND: There is evidence that renal transplant recipients have accelerated atherosclerosis that is manifest by increased cardiovascular morbidity and mortality. The high incidence of atherosclerosis is, in part, related to increased arterial stiffness, vascular dysfunction, elevated oxidative stress, and inflammation associated with immunosuppressive therapy. The carotenoid astaxanthin has shown potent antioxidant and anti-inflammatory properties. OBJECTIVE: The aim was to investigate the effects of oral astaxanthin on arterial stiffness, oxidative stress, and inflammation in renal transplant recipients...
January 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/25183955/evaluation-of-resettin%C3%A2-on-serum-hormone-levels-in-sedentary-males
#5
Mark L Anderson
BACKGROUND: Comparisons of hormones such as dihydrotestosterone (DHT), estradiol (E2), and testosterone indicate their impact on metabolism and body composition. While less is known regarding DHT and E2, testosterone is an androgenic metabolic hormone capable of positively regulating a variety of anabolic and androgenic processes in the body. Accordingly, it has been postulated that the age-related reduction in serum testosterone levels leads to reductions in lean muscle mass, bone mineral density, and other physical conditions that impair physical performance and decrease quality of life...
2014: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/24523587/cognitive-effects-of-a-dietary-supplement-made-from-extract-of-bacopa-monnieri-astaxanthin-phosphatidylserine-and-vitamin-e-in-subjects-with-mild-cognitive-impairment-a-noncomparative-exploratory-clinical-study
#6
Danilo Zanotta, Silvana Puricelli, Guido Bonoldi
A prospective cohort, noncomparative, multicenter trial was conducted to explore the potential of a phytotherapeutic compound, available as a dietary supplement and containing extracts of Bacopa monnieri and Haematococcus pluvialis (astaxanthin) plus phosphatidylserine and vitamin E, in improving cognition in subjects diagnosed with mild cognitive impairment. Enrolled subjects (n=104) were aged 71.2±9.9 years and had a mini-mental state examination score of 26.0±2.0 (mean ± standard deviation). They underwent the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) test and the clock drawing test at baseline and upon completion of a 60-day period of dietary supplementation with one tablet daily of the tested compound...
2014: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/24489447/dietary-intake-of-carotenoids-and-their-antioxidant-and-anti-inflammatory-effects-in-cardiovascular-care
#7
REVIEW
Marco Matteo Ciccone, Francesca Cortese, Michele Gesualdo, Santa Carbonara, Annapaola Zito, Gabriella Ricci, Francesca De Pascalis, Pietro Scicchitano, Graziano Riccioni
Cardiovascular disease related to atherosclerosis represents nowadays the largest cause of morbidity and mortality in developed countries. Due to inflammatory nature of atherosclerosis, several studies had been conducted in order to search for substances with anti-inflammatory activity on arterial walls, able to exert beneficial roles on health. Researches investigated the role of dietary carotenoids supplementation on cardiovascular disease, due to their free radicals scavenger properties and their skills in improving low-density lipoprotein cholesterol resistance to oxidation...
2013: Mediators of Inflammation
https://www.readbyqxmd.com/read/22418926/cancer-chemoprevention-by-carotenoids
#8
REVIEW
Takuji Tanaka, Masahito Shnimizu, Hisataka Moriwaki
Carotenoids are natural fat-soluble pigments that provide bright coloration to plants and animals. Dietary intake of carotenoids is inversely associated with the risk of a variety of cancers in different tissues. Preclinical studies have shown that some carotenoids have potent antitumor effects both in vitro and in vivo, suggesting potential preventive and/or therapeutic roles for the compounds. Since chemoprevention is one of the most important strategies in the control of cancer development, molecular mechanism-based cancer chemoprevention using carotenoids seems to be an attractive approach...
2012: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/22349894/astaxanthin-in-cardiovascular-health-and-disease
#9
REVIEW
Robert G Fassett, Jeff S Coombes
Oxidative stress and inflammation are established processes contributing to cardiovascular disease caused by atherosclerosis. However, antioxidant therapies tested in cardiovascular disease such as vitamin E, C and β-carotene have proved unsuccessful at reducing cardiovascular events and mortality. Although these outcomes may reflect limitations in trial design, new, more potent antioxidant therapies are being pursued. Astaxanthin, a carotenoid found in microalgae, fungi, complex plants, seafood, flamingos and quail is one such agent...
2012: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/22214255/astaxanthin-cell-membrane-nutrient-with-diverse-clinical-benefits-and-anti-aging-potential
#10
REVIEW
Parris Kidd
Astaxanthin, a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits. This molecule neutralizes free radicals or other oxidants by either accepting or donating electrons, and without being destroyed or becoming a pro-oxidant in the process. Its linear, polar-nonpolar-polar molecular layout equips it to precisely insert into the membrane and span its entire width. In this position, astaxanthin can intercept reactive molecular species within the membrane's hydrophobic interior and along its hydrophilic boundaries...
December 2011: Alternative Medicine Review: a Journal of Clinical Therapeutic
https://www.readbyqxmd.com/read/21822408/marine-carotenoids-and-cardiovascular-risk-markers
#11
REVIEW
Graziano Riccioni, Nicolantonio D'Orazio, Sara Franceschelli, Lorenza Speranza
Marine carotenoids are important bioactive compounds with physiological activities related to prevention of degenerative diseases found principally in plants, with potential antioxidant biological properties deriving from their chemical structure and interaction with biological membranes. They are substances with very special and remarkable properties that no other groups of substances possess and that form the basis of their many, varied functions and actions in all kinds of living organisms. The potential beneficial effects of marine carotenoids have been studied particularly in astaxanthin and fucoxanthin as they are the major marine carotenoids...
2011: Marine Drugs
https://www.readbyqxmd.com/read/21556169/astaxanthin-a-potential-therapeutic-agent-in-cardiovascular-disease
#12
REVIEW
Robert G Fassett, Jeff S Coombes
Astaxanthin is a xanthophyll carotenoid present in microalgae, fungi, complex plants, seafood, flamingos and quail. It is an antioxidant with anti-inflammatory properties and as such has potential as a therapeutic agent in atherosclerotic cardiovascular disease. Synthetic forms of astaxanthin have been manufactured. The safety, bioavailability and effects of astaxanthin on oxidative stress and inflammation that have relevance to the pathophysiology of atherosclerotic cardiovascular disease, have been assessed in a small number of clinical studies...
2011: Marine Drugs
https://www.readbyqxmd.com/read/19852884/carotenoids-and-cardiovascular-disease
#13
REVIEW
Graziano Riccioni
Carotenoids are a class of natural fat-soluble pigments found principally in plants. They have potential antioxidant biological properties due to their chemical structure and interaction with biological membranes. The most abundant carotenoids in the diet are beta-carotene, lycopene, lutein, beta-cryptoxanthin, zeaxanthin, and astaxanthin. Numerous epidemiologic studies have supported the hypothesis that antioxidants could be used as an inexpensive means of prevention, and possibly treatment, of cardiovascular diseases, even though findings from interventional trials have been mixed, with some positive findings, many null findings, and some suggestion of harm in certain high-risk populations...
November 2009: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/19656058/astaxanthin-oxidative-stress-inflammation-and-cardiovascular-disease
#14
REVIEW
Robert G Fassett, Jeff S Coombes
It is accepted that oxidative stress and inflammation play an integral role in the pathophysiology of many chronic diseases including atherosclerotic cardiovascular disease. The xanthophyll carotenoid dietary supplement astaxanthin has demonstrated potential as an antioxidant and anti-inflammatory therapeutic agent in models of cardiovascular disease. There have been at least eight clinical studies conducted in over 180 humans using astaxanthin to assess its safety, bioavailability and clinical aspects relevant to oxidative stress, inflammation or the cardiovascular system...
July 2009: Future Cardiology
https://www.readbyqxmd.com/read/19091127/astaxanthin-vs-placebo-on-arterial-stiffness-oxidative-stress-and-inflammation-in-renal-transplant-patients-xanthin-a-randomised-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Robert G Fassett, Helen Healy, Ritza Driver, Iain K Robertson, Dominic P Geraghty, James E Sharman, Jeff S Coombes
BACKGROUND: There is evidence that renal transplant recipients have accelerated atherosclerosis manifest by increased cardiovascular morbidity and mortality. The high incidence of atherosclerosis is, in part, related to increased arterial stiffness, vascular dysfunction, elevated oxidative stress and inflammation associated with immunosuppressive therapy. The dietary supplement astaxanthin has shown promise as an antioxidant and anti-inflammatory therapeutic agent in cardiovascular disease...
2008: BMC Nephrology
https://www.readbyqxmd.com/read/18474276/astaxanthin-a-novel-potential-treatment-for-oxidative-stress-and-inflammation-in-cardiovascular-disease
#16
REVIEW
Fredric J Pashkow, David G Watumull, Charles L Campbell
Oxidative stress and inflammation are implicated in several different manifestations of cardiovascular disease (CVD). They are generated, in part, from the overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that activate transcriptional messengers, such as nuclear factor-kappaB, tangibly contributing to endothelial dysfunction, the initiation and progression of atherosclerosis, irreversible damage after ischemic reperfusion, and even arrhythmia, such as atrial fibrillation. Despite this connection between oxidative stress and CVD, there are currently no recognized therapeutic interventions to address this important unmet need...
May 22, 2008: American Journal of Cardiology
https://www.readbyqxmd.com/read/12804020/safety-of-an-astaxanthin-rich-haematococcus-pluvialis-algal-extract-a-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Gene A Spiller, Antonella Dewell
A growing body of scientific literature indicates that astaxanthin is a more powerful antioxidant than other carotenoids and vitamin E and may confer numerous health benefits. The purpose of this investigation was to conduct a human safety study with a Haematococcus pluvialis algal extract with high levels of astaxanthin. Thirty-five healthy adults age 35-69 years were enrolled in a randomized, double-blind, placebo-controlled trial of 8 weeks' duration. All participants took three gelcaps per day, one at each meal...
2003: Journal of Medicinal Food
https://www.readbyqxmd.com/read/9795974/radical-interception-by-carotenoids-and-effects-on-uv-carcinogenesis
#18
H S Black
Studies employing time-resolved techniques have shown that beta-carotene, astaxanthin, and lycopene behave quite distinctly with respect to radical quenching and stability, lycopene being the least stable. These results are compatible with the relative effects of the various carotenoids on ultraviolet (UV)-mediated carcinogenesis in mice in which a statistically significant exacerbation by beta-carotene and astaxanthin, but not by lycopene, was observed. Interactions between these carotenoids and vitamin C and E radicals not only provide a chemical basis to explain the failure of beta-carotene to provide benefit in recent clinical trials but suggest that future carotenoid supplementation studies should proceed with caution until carotenoid interactions and radical repair mechanism(s) are elucidated...
1998: Nutrition and Cancer
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"