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https://www.readbyqxmd.com/read/29691998/a-novel-method-to-combine-assessment-of-benefit-and-harm-omeract-3x3-methodology-applied-to-two-active-comparator-trials
#1
Maarten Boers, Jasvinder A Singh, Stacey S Cofield, S Louis Bridges, Larry W Moreland, James R O'Dell, Hongsheng Wu, Sarah Leatherman, Jeffrey R Curtis
INTRODUCTION: The Outcome Measures in Rheumatology (OMERACT) '3x3' method analyzes the occurrence of benefit and harm simultaneously at the individual patient level. We applied this method to two recent rheumatoid arthritis (RA) trial datasets. METHODS: Treatment of Early Aggressive RA (TEAR) and the RA Comparison of Active Therapies (RACAT) randomized trial outcomes for safety were defined according to OMERACT as no events, non-serious events, and serious events...
April 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29691957/very-long-term-outcome-of-schizophrenia
#2
REVIEW
Jan Volavka, Jan Vevera
PURPOSE: The principal aim is to review recent data concerning the very long-term outcome of schizophrenia and schizophrenia spectrum disorders. We examine factors that influence outcome, including therapeutic interventions. METHOD: PubMed and Scopus databases were searched for papers published between 2008 and 2017 reporting on prospective studies of schizophrenia or schizophrenia spectrum with a follow-up period ≥5 years with adequate outcome information. Additional publications were found in reference lists and authors' reference libraries...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691955/pharmacist-led-discharge-medication-counselling-a-scoping-review
#3
REVIEW
Aline F Bonetti, Wálleri C Reis, Natália Fracaro Lombardi, Antonio M Mendes, Harli Pasquini Netto, Inajara Rotta, Fernando Fernandez-Llimos, Roberto Pontarolo
RATIONALE, AIMS, AND OBJECTIVES: Discharge medication counselling has produced improved quality of care and health outcomes, especially by reducing medication errors and readmission rates, and improving medication adherence. However, no studies have assembled an evidence-based discharge counselling process for clinical pharmacists. Thus, the present study aims to map the components of the pharmacist-led discharge medication counselling process. METHODS: We performed a scoping review by searching electronic databases (Pubmed, Scopus, and DOAJ) and conducting a manual search to identify studies published up to July 2017...
April 24, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29691950/adapting-evidence-based-clinical-practice-guidelines-at-university-teaching-hospitals-a-model-for-the-eastern-mediterranean-region
#4
Yasser S Amer, Hayfaa A Wahabi, Manal M Abou Elkheir, Ghada A Bawazeer, Shaikh M Iqbal, Maher A Titi, Aishah Ekhzaimy, Khalid A Alswat, Rasmieh A Alzeidan, Lubna A Al-Ansary
RATIONALE, AIMS, AND OBJECTIVES: Clinical practice guidelines (CPGs) are significant tools for evidence-based health care quality improvement. The CPG program at King Saud University was launched as a quality improvement program to fulfil the international accreditation standards. This program was a collaboration between the Research Chair for Evidence-Based Healthcare and Knowledge Translation and the Quality Management Department. This study aims to develop a fast-track method for adaptation of evidence-based CPGs and describe results of the program...
April 24, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29691859/survey-of-rabies-vaccination-status-of-queensland-veterinarians-and-veterinary-students
#5
D Mendez, L Foyle, R Cobbold, R Speare
BACKGROUND: To determine the rabies vaccination status of Queensland veterinarians and veterinary students and their perception of zoonotic risk from Australian bat lyssavirus (ABLV). DESIGN: Cross-sectional questionnaire surveys. METHODS: Questionnaires were sent by post in 2011 to veterinary surgeons registered in Queensland, to final-year veterinary students at James Cook University via SurveyMonkey® in 2013 and to final-year veterinary students at James Cook University and University of Queensland via SurveyMonkey® in 2014...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29691848/children-sustain-high-levels-of-skin-dna-photodamage-with-a-modest-increase-of-serum-25-oh-d-3-after-a-summer-holiday-in-northern-europe
#6
J Narbutt, P A Philipsen, A Lesiak, T Sandberg Liljendahl, D Segerbäck, J Heydenreich, D Chlebna-Sokol, P Olsen, G I Harrison, A Pearson, K Baczynska, M Rogowski-Tylman, H C Wulf, A R Young
BACKGROUND: Childhood solar ultraviolet radiation (UVR) exposure increases the risk of skin cancer in adulthood, which is associated with mutations caused by UVR-induced cyclobutane pyrimidine dimers (CPD). Solar UVR is also the main source of vitamin D, essential for healthy bone development in children. OBJECTIVES: The impact of a 12-day Baltic Sea (54o N) beach holiday on serum 25-dihydroxyvitamin D (25(OH)D3 ) and CPD was assessed in 32 healthy Polish children (skin types I-IV)...
April 24, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29691839/gene-expression-profiles-for-a-prognostic-immunoscore-in-gastric-cancer
#7
D Zeng, R Zhou, Y Yu, Y Luo, J Zhang, H Sun, J Bin, Y Liao, J Rao, Y Zhang, W Liao
BACKGROUND: Increasing evidence has indicated an association between immune infiltration in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on systematic assessments of the immune landscape inferred from bulk tumour transcriptomes, have not been established. The aim was to develop an immune signature, based on the cellular composition of the immune infiltrate inferred from bulk tumour transcriptomes, to improve the prognostic predictions of gastric cancer...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691837/oral-health-status-associated-with-sociodemographic-factors-of-nepalese-schoolchildren-a-population-based-study
#8
Saujanya Karki, Marja-Liisa Laitala, Manoj Humagain, Marjo Seppänen, Jari Päkkila, Vuokko Anttonen
OBJECTIVES: The aim of this study was to investigate the oral health of Nepalese schoolchildren relative to their sociodemographic characteristics. METHODS: This school-based, cross-sectional study was conducted among 5-6-, 12- and 15-year-old Nepalese children in 18 randomly selected districts of the 75 in Nepal. Clinical parameters were recorded according to the World Health Organization (WHO) guidelines. Results were presented as mean (SD) and proportions; the chi-square test, t-test and one way-ANOVA were also performed...
April 25, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29691835/rufinamide-add-on-therapy-for-refractory-epilepsy
#9
REVIEW
Mariangela Panebianco, Hemanshu Prabhakar, Anthony G Marson
BACKGROUND: Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often requiring treatment with a combination of AEDs. In this review, we summarised the current evidence regarding rufinamide, a novel anticonvulsant medication, which, as a triazole derivative, is structurally unrelated to any other currently used anticonvulsant medication, when used as an add-on treatment for refractory epilepsy...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29691828/silk-fibroin-based-hydrogels-and-scaffolds-for-osteochondral-repair-and-regeneration
#10
Viviana P Ribeiro, Sandra Pina, J Miguel Oliveira, Rui L Reis
Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691823/layered-scaffolds-for-osteochondral-tissue-engineering
#11
Diana Ribeiro Pereira, Rui L Reis, J Miguel Oliveira
Despite huge efforts, tissue engineers and orthopedic surgeons still face a great challenge to functionally repair osteochondral (OC) defects. Nevertheless, over the past decade great progress has been made to find suitables strategies towards OC regeneration. In the clinics, some osteochondral tissue engineering (OCTE) strategies have already been applied although with some incongruous outcomes as OC tissue is complex in its architecture and function. In this chapter, we have summarized current OCTE strategies that are focused on hierarchical scaffold design, mainly layered scaffolds...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691813/comparison-of-healing-of-full-thickness-skin-wounds-grafted-with-multidirectional-or-unidirectional-autologous-artificial-dermis-differential-delivery-of-healing-biomarkers
#12
M R Fontanilla, S Casadiegos, R H Bustos, M A Patarroyo
Cytokines, chemokines, and growth and remodeling factors orchestrate wound healing when skin damage occurs. During early stages, when the wound is still open, detection and quantification of these compounds might provide biomarkers of skin wound healing, which could aid to complete the scenario provided by clinical follow-up data and histological and histomorphometric analyses. This work assessed and compared the healing of full-thickness skin wounds grafted with artificial dermis made with autologous skin fibroblasts and unidirectional or multidirectional type I collagen scaffolds to test this hypothesis...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29691809/standardization-of-simple-auxiliary-method-beneficial-to-total-endoscopic-thyroidectomy-on-patients-with-ptc-based-on-retrospective-study-of-356-cases
#13
Shouyi Yan, Wenxin Zhao, Bo Wang, Liyong Zhang
OBJECTIVE: Total endoscopic thyroidectomy (TET) is paid increasing attention to by patients, especially those with thyroid carcinoma. The aim of this study is to evaluate the clinic feasibility of standardization of simple auxiliary method (SOSAM) involved in operating bed adjustment, location of skin traction points and thyroid retractor points for the TET via bilateral breast approach. METHODS: A retrospective study was performed on 356 patients with thyroid carcinoma, who had undergone the TET...
April 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29691782/cost-effectiveness-of-aspirin-adherence-for-secondary-prevention-of-cardiovascular-events
#14
Laurence M Djatche, Stefan Varga, Robert D Lieberthal
BACKGROUND: Suboptimal adherence to aspirin therapy for secondary prevention of cardiovascular (CV) events is an important public health problem. Prior studies have demonstrated non-adherent patients are at higher risk of experiencing CV events. OBJECTIVES: This study aimed to estimate the clinical and economic outcomes of aspirin non-adherence in patients with a prior primary CV event. METHODS: We developed a Markov model to estimate the cost-effectiveness of aspirin adherence from a generic US managed care payer perspective over a 5-year time horizon...
April 24, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29691773/etelcalcetide-for-treating-secondary-hyperparathyroidism-an-evidence-review-group-evaluation-of-a-nice-single-technology-appraisal
#15
Micah Rose, Jonathan Shepherd, Petra Harris, Karen Pickett, Joanne Lord
The manufacturer of the calcimimetic drug etelcalcetide was invited to make an evidence submission as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) programme. Within this submission, they reported evidence on the clinical and cost effectiveness of etelcalcetide for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on haemodialysis. The Southampton Health Technology Assessments Centre (SHTAC), part of the Wessex Institute at the University of Southampton, was the independent Evidence Review Group (ERG) commissioned to appraise the company's submission...
April 25, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29691767/prognostic-impact-of-final-kissing-balloon-technique-after-crossover-stenting-for-the-left-main-coronary-artery-from-the-aoi-lmca-registry
#16
Koji Nishida, Mamoru Toyofuku, Takeshi Morimoto, Masanobu Ohya, Yasushi Fuku, Hirooki Higami, Kyohei Yamaji, Hiromi Muranishi, Yuhei Yamaji, Daisuke Furukawa, Tomohisa Tada, Euihong Ko, Kazushige Kadota, Kenji Ando, Hiroki Sakamoto, Takashi Tamura, Kazuya Kawai, Takeshi Kimura
It is still uncertain whether the final kissing balloon technique (FKBT) is mandatory after crossover stenting for the left main coronary artery (LMCA). Assessing Optimal Percutaneous Coronary Intervention for LMCA (AOI-LMCA) registry, a 6-center retrospective registry, enrolled 1809 consecutive patients for LMCA stenting in Japan. In the present analysis, 5-year clinical outcomes were compared between non-FKBT (n = 160) and FKBT (n = 578) groups in patients treated with crossover stenting with drug-eluting stents from the LMCA to the left anterior descending artery...
April 24, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29691761/open-tibial-inlay-pcl-reconstruction-surgical-technique-and-clinical-outcomes
#17
REVIEW
Evan E Vellios, Kristofer J Jones, David R McAllister
PURPOSE OF REVIEW: To review the current literature on clinical outcomes following open tibial inlay posterior cruciate ligament (PCL) reconstruction and provide the reader with a detailed description of the author's preferred surgical technique. RECENT FINDINGS: Despite earlier biomechanical studies which demonstrated superiority of the PCL inlay technique when compared to transtibial techniques, recent longitudinal cohort studies have shown no significant differences in clinical or functional outcomes at 10-year follow-up...
April 24, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29691681/the-impact-of-the-ryan-white-hiv-aids-medical-case-management-program-on-hiv-clinical-outcomes-a-longitudinal-study
#18
Julia D López, Enbal Shacham, Tawnya Brown
Medical case management (MCM) is a core medical service in The Ryan White HIV/AIDS Program and aims to provide treatment and care for people living with HIV/AIDS by engaging, identifying and eliminating barriers to HIV care. Little research has examined the impact of this intervention; therefore, the purpose of this study was to examine the how MCM affects HIV clinical outcomes. The study took place at a midwestern, outpatient infectious diseases clinic. This study utilized a longitudinal, retrospective study design to analyze to the impact of MCM engagement on HIV clinical outcomes (viral loads, CD4 counts) from 2009 to 2015 as a time-varying predictor...
April 24, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29691651/long-term-results-of-laparoscopic-liver-resection-for-the-primary-treatment-of-hepatocellular-carcinoma-role-of-the-surgeon-in-anatomical-resection
#19
Woo-Hyoung Kang, Ki-Hun Kim, Dong-Hwan Jung, Gil-Chun Park, Seok-Hwan Kim, Hwui-Dong Cho, Sung-Gyu Lee
BACKGROUND: Liver resection is a potentially curative therapy for hepatocellular carcinoma (HCC). LLR is a newly developed and safe technique associated with shorter hospital stay, less pain, better cosmetic outcomes, and similar complication rates as open surgery; however, data on its long-term outcomes remain scarce. METHODS: We retrospectively examined the clinical and follow-up data of 234 patients who underwent LLR (performed by a single surgeon in all cases) for the primary treatment of HCC between July 2007 and December 2015 at Asan Medical Center...
April 24, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29691645/healthcare-associated-pneumonia-and-hospital-acquired-pneumonia-bacterial-aetiology-antibiotic-resistance-and-treatment-outcomes-a-study-from-north-india
#20
Sandeep Kumar, Rafi Ahmed Jan, Bashir Ahmad Fomda, Roohi Rasool, Parvaiz Koul, Sonaullah Shah, Umar Hafiz Khan, Syed Mudasir Qadri, Shariq Rashid Masoodi, Suhail Mantoo, Mudasir Muzamil
BACKGROUND: Data regarding the comparative profiling of HCAP and HAP from developing countries like India are scant. We set out to address the microbial aetiology, antibiotic resistance and treatment outcomes in patients with HCAP and HAP. METHODS: 318 consenting patients with HCAP (n = 165, aged 16-90 years; median 60 years; 97 males) or HAP (n = 153; aged 16-85 years; median 45 years; 92 males) presenting to a tertiary care hospital in North India from 2013 to 2015 were prospectively recruited for the study...
April 25, 2018: Lung
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