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https://www.readbyqxmd.com/read/29458195/human-dorsal-root-ganglion-pulsed-radiofrequency-treatment-modulates-cerebrospinal-fluid-lymphocytes-and-neuroinflammatory-markers-in-chronic-radicular-pain
#1
Basabjit Das, Melissa Conroy, David Moore, Joanne Lysaght, Connail McCrory
Radicular pain is a common cause of disability. Traditionally treatment has been either epidural steroid injection providing short-term relief or surgery with associated complications. Pulsed radiofrequency (PRF) applied to the Dorsal Root Ganglion (DRG) is a minimally invasive day-care treatment, which is gaining significant clinical acceptance in a selective group of patients with pure radicular pain. Greater insights into the immunomodulatory effects of this procedure may help to further optimise its application and find alternative treatment options...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458192/magnetic-resonance-imaging-safety-in-non-conditional-pacemaker-and-defibrillator-recipients-a-meta-analysis-and-systematic-review
#2
Anand D Shah, Mike A Morris, David S Hirsh, Megan Warnock, Yijian Huang, Mike Mollerus, Faisal M Merchant, Anshul M Patel, David B Delurgio, Adarsh U Patel, Michael H Hoskins, Mikhael F El Chami, Angel R Leon, Jonathan J Langberg, Michael S Lloyd
BACKGROUND: Recommendations regarding performance of MRI in non-MRI conditional pacemaker and defibrillator recipients are evolving. Previous studies suggest low adverse event rates with MRI in non-conditional CIED recipients, but low power limits optimal characterization of risk. OBJECTIVE: In order to improve power, a systematic review and meta-analysis was performed to characterize the clinical risk associated with MRI in CIED recipients. METHODS: PUBMED and CINAHL indexed articles from 1990-2017 were queried...
February 16, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29458132/therapeutic-drug-monitoring-in-treatment-experienced-hiv-infected-patients-receiving-darunavir-based-salvage-regimens-a-case-series
#3
Sébastien Landry, Chi-Nan Chen, Nimish Patel, Alice Tseng, Richard G Lalonde, Denis Thibeault, Steven Sanche, Nancy L Sheehan
Therapeutic drug monitoring (TDM) constitutes a compelling approach for the optimization of antiretroviral therapy in treatment-experienced HIV-1 patients. While various inhibitory indices have been proposed to predict virologic outcome, there is a lack of consensus on the clinical value of TDM. Here, we report the comparative results of TDM in 14 HIV-1-infected patients who had previously received at least two different PI-based regimens and who initiated darunavir (DRV)-based salvage therapy. Pharmacokinetic/pharmacodynamics (PK/PD) parameters were calculated for each subject...
February 16, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29457984/cardio-oncology-the-role-of-advanced-echocardiography-in-cancer-patients
#4
Lucia Venneri, Giacomo Zoppellaro, Rajdeep S Khattar
Cardio-oncology is a rapidly growing field aimed at improving the quality of care of cancer patients by preventing and monitoring cardiovascular complications resulting from cancer treatment. Cardiac imaging, and in particular, transthoracic echocardiography, plays an essential role in the baseline assessment and serial follow-up of cardio-oncology patients. Areas covered: This review article discusses the role of cardiac imaging with a focus on advanced echocardiography for the detection and management of cancer therapy related cardiovascular complications, in particular, left ventricular dysfunction and heart failure...
February 19, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29457964/liver-imaging-reporting-and-data-system-patient-outcomes-for-category-4-and-5-nodules
#5
Sang Hyun Choi, Jae Ho Byun, Young-Suk Lim, So Jung Lee, So Yeon Kim, Hyung Jin Won, Yong Moon Shin, Pyo-Nyun Kim
Purpose To determine the outcomes after initial therapy in patients with chronic liver disease and retrospectively assigned Liver Imaging Reporting and Data System (LI-RADS; version 2014) category 4 (LR-4) and 5 (LR-5) nodules at gadoxetate disodium-enhanced MR imaging. Materials and Methods In this retrospective study, 260 patients with a single LR-4 (n = 132) or LR-5 (n = 128) nodule who were assigned a LI-RADS category were included. Patients were identified between January 2012 and December 2012, and were initially treated by resection, liver transplant, radiofrequency ablation (RFA), or transcatheter arterial chemoembolization (TACE) according to the Barcelona Clinic Liver Cancer staging system...
February 19, 2018: Radiology
https://www.readbyqxmd.com/read/29457873/the-impact-of-video-nasal-endoscopy-on-patient-satisfaction
#6
Vidur Bhalla, D David Beahm, Kevin J Sykes, Kavindu K Ndeti, Alexander G Chiu
BACKGROUND: Video nasal endoscopy has significant associated expense for practices, but its use has been justified by the benefit it provides to the examiner. No study has examined the perceived benefit to the patient. In this study, the impact of video endoscopy on patient satisfaction is evaluated. METHODS: A prospective, randomized, single-blinded study was performed on new patients receiving care in the rhinology clinics of a tertiary-care center. Patients were randomized into the standard endoscopic examination (SEE) or video endoscopic examination (VEE) groups...
February 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29457844/effect-of-type-d-personality-on-smoking-status-and-their-combined-impact-on-outcome-after-acute-myocardial-infarction
#7
Egidio Imbalzano, Marco Vatrano, Sebastiano Quartuccio, Roberto Ceravolo, Vincenzo Antonio Ciconte, Paola Rotella, Renato Pardeo, Giovanni Trapani, Pasquale De Fazio, Cristina Segura-Garcia, Rossella Costantino, Antonino Saitta, Giuseppe Mandraffino
BACKGROUND: Smoking cessation is correlated with several psychological, social, biological, and pharmacological aspects. The combined tendency to experience negative emotions and to inhibit the expression of these emotions is indicated as "type D personality," an independent risk marker for clinical outcome in cardiac disease. Despite this effect of type D personality on cardiovascular disease, it is still unclear whether this personality trait may influence smoking cessation after a myocardial infarction...
February 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29457831/low-t3-syndrome-as-a-predictor-of-poor-prognosis-in-chronic-lymphocytic-leukemia
#8
Rui Gao, Rui-Ze Chen, Yi Xia, Jin-Hua Liang, Li Wang, Hua-Yuan Zhu, Jia-Zhu Wu, Lei Fan, Jian-Yong Li, Tao Yang, Wei Xu
Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Two hundred and fifty-eight patients with detailed thyroid hormone profile at CLL diagnosis were enrolled. Low T3 syndrome was defined by low free T3 (FT3) level accompanied by normal-to-low free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) levels...
February 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29457700/impact-of-home-spirometry-on-medication-adherence-among-adolescents-with-cystic-fibrosis
#9
Aarti Shakkottai, Niko Kaciroti, Lauren Kasmikha, Samya Z Nasr
OBJECTIVE: Medication adherence among adolescents with cystic fibrosis (CF) is often suboptimal and this has significant impact on their health and quality of life. The purpose of the study was to evaluate the impact of frequent home pulmonary function (PFT) monitoring on medication adherence among adolescents with CF. HYPOTHESIS: We hypothesized that weekly home PFT monitoring will improve adherence while not significantly adding to the treatment burden. METHODS: Individuals aged 12-21 years with CF were provided a spirometer to measure PFTs weekly for 1 year...
February 19, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29457668/the-relationships-between-depression-neuroticism-and-attitudes-nda-model-in-heroin-abusers-in-taiwan
#10
Kun-Hua Lee, Cheng-Fang Yen
BACKGROUND AND OBJECTIVES: Heroin use is a severe problem worldwide. To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined. We created and assessed a neuroticism, depression, attitudes, and heroin addiction (NDA) model. METHODS: In this cross-sectional study, 234 patients undergoing methadone replacement treatment were recruited from psychiatric clinics. We used Structural Equation Modeling (SEM) to assess all for neuroticism, depression, and a positive outcome expectancy (POE) (attitudes)...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457639/hepatitis-e-virus-infection-in-hiv-infected-patients-a-large-cohort-study-in-yunnan-province-china
#11
Shiyi Zhou, Li Ren, Xueshan Xia, Zhijiang Miao, Fen Huang, Yunlong Li, Mei Zhu, Zhenrong Xie, Yu Xu, Yuan Qian, Qiuwei Pan, Kunhua Wang
BACKGROUND & AIMS: Hepatitis E virus (HEV) infection in immunocompromised patients often results in distinct outcome, compared to the infection in general population. This study aimed to investigate the prevalence, potential risk factors and clinical features of HEV infection among HIV patients treated with antiretroviral therapy (ART) in Yunnan province, China. METHODS: A total of 770 HIV-infected patients between May 2015 and February 2016 were enrolled in Yunnan, China...
February 19, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29457630/combination-drug-delivery-via-multilamellar-vesicles-enables-targeting-of-tumor-cells-and-tumor-vasculature
#12
Yarong Liu, Yu Jeong Kim, Natnaree Siriwon, Jennifer A Rohrs, Zhiqiang Yu, Pin Wang
Blood vessel development is critical for the continued growth and progression of solid tumors and, therefore, makes an attractive target for improving cancer therapy. Indeed, vascular-targeted therapies have been extensively explored but they have shown minimal efficacy as monotherapies. Combretastatin A4 (CA-4) is a tubulin-binding vascular disrupting agent that selectively targets the established tumor endothelium, causing rapid vascular beak down. Despite its potent anticancer potential, the drug has dose-limiting side effects, particularly in the form of cardiovascular toxicity...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29457627/combination-pharmacotherapy-for-the-treatment-of-fibromyalgia-in-adults
#13
REVIEW
Joelle Thorpe, Bonnie Shum, R Andrew Moore, Philip J Wiffen, Ian Gilron
BACKGROUND: Fibromyalgia is a chronic widespread pain condition affecting millions of people worldwide. Current pharmacotherapies are often ineffective and poorly tolerated. Combining different agents could provide superior pain relief and possibly also fewer side effects. OBJECTIVES: To assess the efficacy, safety, and tolerability of combination pharmacotherapy compared to monotherapy or placebo, or both, for the treatment of fibromyalgia pain in adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, and Embase to September 2017...
February 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29457585/training-nurses-in-a-competency-framework-to-support-adults-with-epilepsy-and-intellectual-disability-the-epaid-cluster-rct
#14
Howard Ring, James Howlett, Mark Pennington, Christopher Smith, Marcus Redley, Caroline Murphy, Roxanne Hook, Adam Platt, Nakita Gilbert, Elizabeth Jones, Joanna Kelly, Angela Pullen, Adrian Mander, Cam Donaldson, Simon Rowe, James Wason, Fiona Irvine
BACKGROUND: People with an intellectual (learning) disability (ID) and epilepsy have an increased seizure frequency, higher frequencies of multiple antiepileptic drug (AED) use and side effects, higher treatment costs, higher mortality rates and more behavioural problems than the rest of the population with epilepsy. The introduction of nurse-led care may lead to improvements in outcome for those with an ID and epilepsy; however, this has not been tested in a definitive clinical trial...
February 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29457570/infant-formulae-supplemented-with-prebiotics-are-they-better-than-unsupplemented-formulae-an-updated-systematic-review
#15
Agata Skórka, Małgorzata Pieścik-Lech, Maciej Kołodziej, Hania Szajewska
In 2011, the Committee on Nutrition of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition systematically reviewed published evidence related to the safety and health effects of the administration of formulae supplemented with pro- and/or prebiotics compared with unsupplemented formulae. We updated evidence on the effects of the administration of prebiotic-supplemented infant formulae (IF) compared with unsupplemented IF. Five databases were searched up to March 2017 for randomised controlled trials...
February 19, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29457521/relationships-between-race-ethnicity-and-health-care-utilization-among-older-post-acute-home-health-care-patients
#16
Jo-Ana D Chase, David Russell, Liming Huang, Alexandra Hanlon, Melissa O'Connor, Kathryn H Bowles
Few studies have explored racial/ethnic differences in health care outcomes among patients receiving home health care (HHC), despite known differences in other care settings. We conducted a retrospective cohort study examining racial/ethnic disparities in rehospitalization and emergency room (ER) use among post-acute patients served by a large northeastern HHC agency between 2013 and 2014 ( N = 22,722). We used multivariable binomial logistic regression to describe the relationship between race/ethnicity and health care utilization outcomes, adjusting for individual-level factors that are conceptually related to health service use...
February 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29457513/qualifying-the-difficulty-of-embryo-transfer-with-a-visual-analogue-scale-and-assessing-its-impact-on-ivf-outcomes
#17
Edward Coats, Hannah Carden, Lyndsey Zujovic, Walid Maalouf, James Hopkisson, Nicholas Raine-Fenning
The aim of this study was to determine whether a continuous visual analogue scale (VAS) is a reliable tool to grade embryo transfer (ET) difficulty when assessing IVF outcomes. No standardized grading system exists for reporting ET 'difficulty' which is typically recorded in descriptive terms. Clinicians performing 188 fresh single ETs between November 2014 and May 2016 also recorded a VAS score (0-100). Embryo transfers were stratified into three levels of ET 'difficulty': (A) 'easy' - no resistance; (B) 'medium' - resistance overcome by advancing the catheter's outer sheath; and (C) 'difficult' - a malleable stylet was required to overcome resistance; and these compared to the VAS scores...
February 19, 2018: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/29457488/referral-patterns-and-implementation-costs-of-the-partners-in-recovery-initiative-in-gippsland-learnings-for-the-national-disability-insurance-scheme
#18
Anton N Isaacs, Kim Dalziel, Keith Sutton, Darryl Maybery
OBJECTIVE: The purpose of this paper is to provide some learnings for the NDIS from the referral pattern and cost of implementing the Partners in Recovery initiative of Gippsland. METHOD: Information on referral areas made for each consumer was collated from support facilitators. Cost estimates were determined using budget estimates, administrative costs and a literature review and are reported from a government perspective. RESULTS: Sixty-three per cent of all referrals were made to organisations that provided multiple types of services...
February 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29457445/model-for-end-stage-liver-disease-and-seven-derivations-to-prioritize-liver-transplant-candidates-which-is-the-winner
#19
Fariba Tohidinezhad, Saeid Eslami, Ameen Abu-Hanna, Mohsen Aliakbarian
OBJECTIVES: Under the present liver transplant policy, patients with the highest risk of death receive preference for organ placement. The aim of this study was to evaluate the Model for End-stage Liver Disease (MELD) and seven prognostic derivatives of this test for outcome prediction in cirrhotic patients on liver transplant wait lists. MATERIAL AND METHODS: The study included 416 patients (65.9% male; age 49 ± 13.9 years) who were entered to liver transplant wait lists from January 2013 to October 2016...
February 16, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29457418/-outcomes-and-complications-of-tightrope-button-plate-for-repairing-acromioclavicular-dislocation
#20
Yong-Xiang Zuo, Zi-Ping Ma
OBJECTIVE: To study the clinical outcome and complications of Tightrope button plate for repairing acromioclavicular dislocation of Rockwood type III to V. METHODS: From May 2014 to December 2016, 17 patients with acromioclavicular dislocation of type III-V were treated with Tightrope button plate including 10 males and 7 females with an average age 39.8 years old ranging from 20 to 68 years old. Four patients were treated with arthroscopy and 17 patients were treated with mini-invasive by X-ray assisted...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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