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https://www.readbyqxmd.com/read/29046045/comparative-study-of-clinical-and-radiographic-outcomes-of-high-tibial-osteotomy-in-patients-with-kissing-lesions-and-non-kissing-lesions
#1
Oog-Jin Shon, Sang-Jin Park, Bum-Jin Shim, Dong-Yeol Lee
Purpose: High Outerbridge grade lesions of the articular cartilage have been associated with poor outcomes of high tibial osteotomy (HTO). However, there has been no report on the efficacy of HTO in the presence of kissing lesions. The purpose of this study was to compare clinical and radiographic outcomes of HTO between kissing lesion and non-kissing lesion groups. Materials and Methods: Of the patients with medial compartment osteoarthritis and varus deformity treated with HTO between 2007 and 2012, 21 cases with kissing lesions and 22 cases without kissing lesions were selected...
October 19, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/29046041/development-and-content-validation-of-the-transition-readiness-inventory-item-pool-for-adolescent-and-young-adult-survivors-of-childhood-cancer
#2
Lisa A Schwartz, Jessica L Hamilton, Lauren D Brumley, Lamia P Barakat, Janet A Deatrick, Dava E Szalda, Katherine B Bevans, Carole A Tucker, Lauren C Daniel, Eliana Butler, Anne E Kazak, Wendy L Hobbie, Jill P Ginsberg, Alexandra M Psihogios, Elizabeth Ver Hoeve, Lisa K Tuchman
Objective: The development of the Transition Readiness Inventory (TRI) item pool for adolescent and young adult childhood cancer survivors is described, aiming to both advance transition research and provide an example of the application of NIH Patient Reported Outcomes Information System methods. Methods: Using rigorous measurement development methods including mixed methods, patient and parent versions of the TRI item pool were created based on the Social-ecological Model of Adolescent and young adult Readiness for Transition (SMART)...
October 1, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29046003/-ffr-guided-revascularisation-pros-and-cons
#3
Hannes Reuter, Stephan Baldus
An invasive measurement of the fractional flow reserve (FFR) allows the valuation of the individual risk for ischemic events in patients with coronary artery disease. Therefore, FFR has become a valuable tool to guide coronary revascularisations. The cut-off value ≤ 0.80 has been validated in many different subsets of patients. However, FFR values describe a risk continuum with an inverse correlation between FFR value and the risk of events. So FFR should always be interpreted regarding the patient's clinical context, especially in patients with a high risk for rapid disease progression...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29045997/the-influence-of-bis-monitoring-on-sedative-dose-in-pediatric-patients-undergoing-open-muscle-biopsies-a-randomized-controlled-trial
#4
Eva Tschiedel, Oliver Müller, Adela Della Marina, Ursula Felderhoff-Müser, Christian Dohna-Schwake
Background The use of Propofol and Remifentanil for analgosedation in children is common and safe. For sedation monitoring clinical scores as Comfort Score (CS) as well as bispectral index (BIS) are frequently applied. The impact of BIS for sedation monitoring in pediatric patients is still under debate. This prospective study aims to investigate whether dual sedation monitoring of CS and BIS compared with monitoring of CS alone during muscle biopsies in children can reduce sedative doses, reduce awakening time and prevent complications...
October 18, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29045979/-changes-of-serum-krebs-von-den-lungen-6-levels-in-interstitial-lung-disease-associated-with-dermatomyositis-and-secondary-sj%C3%A3-gren-s-syndrome-a-case-report
#5
J F Yu, Y B Jin, J He, Y An, Z G Li
Interstitial lung diseases (ILDs) are a diverse group of pulmonary disorders characterized by various patterns of inflammation and fibrosis in the interstitium of the lung. The underlying pathogenesis of ILDs is complex and associated with multiple rheumatologic conditions, such as systemic sclerosis, rheumatoid arthritis, pollymyositis and dermatomyositis, Sjögren's syndrome, and systemic lupus erythematosus. As the disease progresses, excessive pulmonary fibrosis impairs alveolar gas exchange and damages pulmonary function...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045970/-unilateral-patellar-resurfacing-in-bilateral-total-knee-arthroplasty-a-randomized-controlled-study
#6
J F Wang, Z Li, K S Zhang, F Yuan, R J Li, Q J Zhong, Z P Guan
OBJECTIVE: To perform unilateral patellar resurfacing and contralateral patellar retention in bilateral total knee arthroplasty (TKA) randomly, and to compare the clinical effects of patellar retention with patellar resurfacing in TKA. METHODS: In the study, 14 bilateral knee osteoarthritis (OA) patients were randomized in the bilateral TKA to receive unilateral patellar resurfacing and contralateral patellar retention, including 28 knees, all were females, 53 to 78 years old, with average (66...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045969/-clinical-study-on-locking-plate-for-the-treatment-of-non-osteoporotic-complex-proximal-humeral-fractures
#7
X Li, F L Li, Y Lu, Y M Zhu, S Y Guo, Y J Li, C Y Jiang
OBJECTIVE: To describe long-term results of locking plate used for the treatment of non-osteoporotic fresh three- and four-part proximal humeral fractures with at least 2 years follow-up. METHODS: The functional outcomes and the complications of non-osteoporotic three- and four-part fresh proximal humeral fractures treated with locking plate were assessed retrospectively. The active range of motion, the Constant score, the University of California at Los Angeles (UCLA) shoulder score, the visual analogue score (VAS) were employed to evaluate the postoperative shoulder function, and the radiographic images were taken to evaluate the neck-shaft angle of the proximal humeral and postoperative implant-related complications...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045951/lifestyle-behaviors-and-clinical-outcomes-in-idiopathic-pulmonary-fibrosis
#8
Baruch Vainshelboim, Jose Oliveira, Shimon Izhakian, Avraham Unterman, Mordechai Reuven Kramer
BACKGROUND: Lifestyle behaviors are not well-characterized in idiopathic pulmonary fibrosis (IPF). OBJECTIVES: To assess the association between lifestyle behaviors and clinical outcomes in patients with IPF. METHODS: A total of 34 IPF patients (median age 68 years) were assessed for daily sitting and weekly walking times using the International Physical Activity Questionnaire by in-person interview at baseline, and they were followed up for up to 40 months...
October 19, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29045920/the-association-of-alcohol-consumption-patterns-with-self-rated-physical-health-and-psychiatric-distress-among-afghanistan-and-iraq-era-u-s-veterans
#9
Patrick S Calhoun, Sarah M Wilson, Eric A Dedert, Katherine C Cunningham, Thomas K Burroughs, Terrell A Hicks, Jean C Beckham, Harold S Kudler, Kristy Straits-Troster
Alcohol misuse is associated with negative mental and physical health outcomes, which presents a public health concern in veterans. However, less is known regarding outcomes among veterans with low to moderate alcohol consumption. This study included veterans with military service in Iraq and/or Afghanistan (N = 1083) who resided in the VA Mid-Atlantic region catchment area (North Carolina, Virginia, and parts of West Virginia). Participants completed a mailed survey that inquired about demographics, past-year alcohol consumption, self-rated physical health, and psychiatric symptoms...
September 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29045853/symptomatic-vasospasms-as-a-life-threatening-complication-after-transsphenoidal-surgery
#10
Katharina Osterhage, Patrick Czorlich, Till R Burkhardt, Roman Rotermund, Ulrich Grzyska, Jörg Flitsch
OBJECTIVE: To identify symptomatic vasospasms as a rare complication after pituitary surgery with emphasis on management and outcome. DESIGN AND METHODS: In a retrospective design, 1997 patient charts undergoing microscopic transsphenoidal surgery from 2008 till 2016 were retrospectively analyzed regarding postoperative vasospastic events, its' clinical management, and neurological outcome. RESULTS: Four patients (0.2%) were identified, who developed neurological deficits in the postoperative phase caused by proven vasospasms due to subarachnoid hemorrhage (SAH)...
October 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29045800/survival-and-complications-of-single-dental-implants-in-the-edentulous-mandible-following-immediate-or-delayed-loading-a-randomized-controlled-clinical-trial
#11
M Kern, W Att, E Fritzer, S Kappel, R G Luthardt, T Mundt, D R Reissmann, M Rädel, M Stiesch, S Wolfart, N Passia
It was the aim of this 24-mo randomized controlled clinical trial to investigate whether the survival of a single median implant placed in the edentulous mandible to retain a complete denture is not compromised by immediate loading. Secondary outcomes were differences in prosthetic complications between the loading principles. Each of the 158 patients who received an implant was randomly assigned to the immediate loading group ( n = 81) or the delayed loading group ( n = 77). Recall visits were performed 1 mo after implant placement (for only the delayed loading group) and 1, 4, 12, and 24 mo after implant loading...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29045770/treatment-to-enhance-cognition-in-bipolar-disorder-trec-bd-efficacy-of-a-randomized-controlled-trial-of-cognitive-remediation-versus-active-control
#12
Kathryn E Lewandowski, Sarah H Sperry, Bruce M Cohen, Lesley A Norris, Garrett M Fitzmaurice, Dost Ongur, Matcheri S Keshavan
OBJECTIVE: Cognitive dysfunction is a core symptom dimension in bipolar disorder and a strong predictor of functional outcomes. Cognitive remediation (CR) produces moderate, durable effects on cognition in patients with schizophrenia; however, studies of CR in patients with bipolar disorder are sparse and findings have been mixed. Thus, the aim of this study was to evaluate the effects of CR versus active control in patients with bipolar disorder with psychosis. METHODS: Patients with a DSM-IV diagnosis of bipolar disorder with psychosis (n = 75) were randomized to a 70-hour computerized CR program or a dose-matched computer control using a parallel design with 1:1 allocation between July 2011 and November 2015...
October 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29045765/oral-anti-diabetic-agents-for-women-with-established-diabetes-impaired-glucose-tolerance-or-previous-gestational-diabetes-planning-pregnancy-or-pregnant-women-with-pre-existing-diabetes
#13
REVIEW
Joanna Tieu, Suzette Coat, William Hague, Philippa Middleton, Emily Shepherd
BACKGROUND: While most guidance recommends the use of insulin in women whose pregnancies are affected by pre-existing diabetes, oral anti-diabetic agents may be more acceptable to women. The effects of these oral anti-diabetic agents on maternal and infant health outcomes need to be established in pregnant women with pre-existing diabetes or impaired glucose tolerance, as well as in women with previous gestational diabetes mellitus preconceptionally or during a subsequent pregnancy. OBJECTIVES: To investigate the effects of oral anti-diabetic agents in women with established diabetes, impaired glucose tolerance or previous gestational diabetes who are planning a pregnancy, or pregnant women with pre-existing diabetes, on maternal and infant health...
October 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29045745/long-term-oral-appliance-therapy-improves-daytime-function-and-mood-in-upper-airway-resistance-syndrome-patients
#14
Luciana B M Godoy, Luciana Palombini, Dalva Poyares, Cibele Dal-Fabbro, Thaís Moura Guimarães, Priscila Calixto Klichouvicz, Sergio Tufik, Sonia Maria Togeiro
Objectives: To evaluate the long term effects of an oral appliance on clinical symptoms, respiratory sleep parameters, sleep quality and sustained attention in patients with Upper Airway Resistance Syndrome (UARS) compared with placebo. Methods: This study was a randomized placebo-controlled clinical trial. Thirty UARS patients were randomized in two groups: placebo and mandibular advancement device (MAD) groups. UARS criteria were presence of sleepiness (Epworth Sleepiness Scale ≥ 10) and/or fatigue (Modified Fatigue Impact Scale ≥ 38) associated with an apnea/hypopnea index (AHI) ≤ 5 and a respiratory disturbance index (RDI) > 5 events/hour of sleep, and/or flow limitation in more than 30% of total sleep time...
October 17, 2017: Sleep
https://www.readbyqxmd.com/read/29045741/respiratory-syncytial-virus-genotypes-host-immune-profiles-and-disease-severity-in-young-children-hospitalized-with-bronchiolitis
#15
Rosa Rodriguez-Fernandez, Lorena I Tapia, Chin-Fen Yang, Juan Pablo Torres, Susana Chavez-Bueno, Carla Garcia, Lisa M Jaramillo, Melissa Moore-Clingenpeel, Hasan S Jafri, Mark E Peeples, Pedro A Piedra, Octavio Ramilo, Asuncion Mejias
Background: Data on how RSV genotypes influence disease severity and host immune responses is limited. We characterized the genetic variability of RSV during five seasons, and evaluated the role of RSV subtypes, genotypes and viral loads on disease severity and host transcriptional profiles. Methods: Prospective, observational study including a convenience sample of healthy infants hospitalized with RSV bronchiolitis. Nasopharyngeal samples for viral load quantitation, typing and genotyping, and blood samples for transcriptome analyses were obtained within 24h of hospitalization...
October 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29045736/clinical-trial-parameters-that-influence-outcomes-in-lupus-trials-that-use-the-systemic-lupus-erythematosus-responder-index
#16
Kenneth C Kalunian, Murray B Urowitz, David Isenberg, Joan T Merrill, Michelle Petri, Richard A Furie, Mary-Ann Morgan-Cox, Rebecca Taha, Steven Watts, Maria Silk, Matthew D Linnik
Objective: The SLE Responder Index (SRI) is a composite endpoint used in SLE trials. This investigation examined the clinical trial elements that drive response measured by the SRI. Methods: Analyses are based on data from two phase 3 trials (n = 2262) that evaluated the impact of an anti-B-cell activating factor antibody on disease activity using SRI-5 as the primary endpoint (ClinicalTrials.gov NCT01196091 and NCT01205438). Results: The SRI-5 response rate at week 52 for all patients was 32...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045726/efficacy-and-safety-outcomes-in-systematic-reviews-of-interventions-for-postoperative-pain-in-children-comparison-against-the-recommended-core-outcome-set
#17
Krste Boric, Svjetlana Dosenovic, Antonia Jelicic Kadic, Matija Boric, Milka Jeric, Livia Puljak
Objective: To investigate the range of efficacy and safety outcomes used in systematic reviews (SRs) of randomized controlled trials (RCTs) of interventions for postoperative pain in children and compare them with outcome domains recommended in the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (PedIMMPACT). Methods: Five electronic databases were searched: MEDLINE, Cochrane Database of Systematic Reviews, DARE, CINAHL, and PsycINFO...
October 16, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29045715/towards-precision-medicine-in-anca-associated-vasculitis
#18
Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers
ANCA-associated vasculitis (AAV) is characterized by inflammation and destruction of small and medium-sized vessels. Current management strategies for AAV have been validated in large groups of patients. However, recent insights indicate that distinct patient subsets may actually exist within AAV, thereby justifying the development of more personalized treatment strategies. In this review, we discuss current evidence for a better classification of AAV based on ANCA type. We describe how thus defined categories of AAV patients may differ in genetic background, clinical presentation, immune pathology, response to treatment and disease outcome...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045710/radiation-induced-cognitive-toxicity-pathophysiology-and-interventions-to-reduce-toxicity-in-adults
#19
Christopher Wilke, David Grosshans, Joseph Duman, Paul Brown, Jing Li
Radiotherapy is ubiquitous in the treatment of patients with both primary brain tumors as well as disease which is metastatic to the brain. This therapy is not without cost, however, as cognitive decline is frequently associated with cranial radiation, particularly with whole brain radiotherapy (WBRT). The precise mechanisms responsible for radiation-induced morbidity remain incompletely understood and continue to be an active area of ongoing research. In this article, we review the hypothetical means by which cranial radiation induces cognitive decline as well as potential therapeutic approaches to prevent, minimize or reverse treatment-induced cognitive deterioration...
October 14, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29045667/survey-of-reproductive-experiences-and-outcomes-of-cancer-survivors-who-stored-reproductive-material-before-treatment
#20
K Hammarberg, M Kirkman, C Stern, R I McLachlan, G Clarke, F Agresta, D Gook, L Rombauts, B Vollenhoven, J R W Fishe
STUDY QUESTION: What are the reproductive experiences and outcomes of people who store reproductive material before cancer treatment? SUMMARY ANSWER: Of respondents who had tried to achieve pregnancy since completing cancer treatment almost all had succeeded, in most cases through natural conception. WHAT IS KNOWN ALREADY: People of reproductive age who are diagnosed with cancer can cryopreserve reproductive material to guard against the adverse effects on fertility of gonadotoxic treatment...
October 17, 2017: Human Reproduction
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