Henrique Nunes Pereira Oliva, Tiago Paiva Prudente, Eric J Nunes, Kelly P Cosgrove, Rajiv Radhakrishnan, Marc N Potenza, Gustavo A Angarita
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies, synaptic density markers, like spine density, are altered by substances of abuse (e.g., alcohol, amphetamine, cannabis, cocaine, opioids, nicotine). These changes could be linked to phenomena including behavioral sensitization and drug self-administration in rodents. However, studies have produced heterogeneous results for spine density across substances and brain regions...
April 2, 2024: Molecular Psychiatry