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https://www.readbyqxmd.com/read/29160511/the-importance-of-audiometric-monitoring-in-patients-with-multidrug-resistant-tuberculosis
#1
Karla Anacleto de Vasconcelos, Silvana Maria Monte Coelho Frota, Antonio Ruffino-Netto, Afrânio Lineu Kritski
INTRODUCTION: A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patients treated for MDR-TB and to identify associations between these complaints and the type of aminoglycoside used...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160504/nasal-carriage-rate-of-methicillin-resistant-staphylococcus-aureus-among-iranian-healthcare-workers-a-systematic-review-and-meta-analysis
#2
Mohammad Emaneini, Fereshteh Jabalameli, Hosseinali Rahdar, Willem B van Leeuwen, Reza Beigverdi
Globally, methicillin-resistant Staphylococcus aureus (MRSA) remains a major cause of healthcare-associated infections. Healthcare workers (HCWs), patients and the environment may act as reservoirs for the spread of MRSA to patients and other HCWs. Screening and eradication of MRSA colonization is an effective method of reducing the MRSA infection rate. There are limited data on the prevalence of MRSA among Iranian HCWs. We performed a systematic search by using different electronic databases including Medline (via PubMed), Embase, Web of Science, and Iranian Databases (from January 2000 to July 2016)...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160353/in-vitro-evaluation-of-ivermectin-moxidectin-albendazole-and-pyrantel-against-cyathostomins-of-horses
#3
Marcelo Beltrão Molento, Ricardo José Canever
Cyathostomins are the most prevalent nematodes of horses, and multidrug resistance has been reported worldwide. There is a need to implement alternative drug monitoring analytical tests. The objective of this study was to determine the consistency (5 repetitions) of the larval migration on agar test (LMAT) using ivermectin, moxidectin, pyrantel or albendazole against cyathostomin infective-stage larvae in eight different concentrations. LMAT showed a strong coefficient of determination (R2 > 0.91), between the test repetitions (n=5)...
November 9, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29159032/use-of-ceftolozane-tazobactam-in-a-cystic-fibrosis-patient-with-multidrug-resistant-pseudomonas-infection-and-renal-insufficiency
#4
Katie Stokem, Jonathan B Zuckerman, David P Nicolau, Minkey Wungwattana, Edmund H Sears
We report the successful use of ceftolozane/tazobactam (C/T) to treat a pulmonary exacerbation in a 35 year old female, post lung transplant, with cystic fibrosis (CF), malnutrition, chronic kidney disease, and multi-drug resistant Pseudomonas aeruginosa infection (MDR PSA). Given the complexity of the clinical profile, we measured drug levels of C/T during treatment of her current exacerbation to determine pharmacokinetics. The patient achieved an estimated ceftolozane peak of 174.1 μg/mL and trough of 9...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29158906/molecular-characterization-of-panton-valentine-leukocidin-pvl-toxin-encoding-phages-from-south-india
#5
V Balaji, D B Yamuna, Y I Francis, G Priya Doss
A total of 19 methicillin-resistant Staphylococcus aureus (MRSA) isolates were investigated for Panton-Valentine leukocidin (PVL) toxin, PVL gene sequence variation and PVL-encoding phages. Whole genome sequencing was performed for all isolates. Analysis of MRSA isolates (n = 19) confirmed that most MRSA (n = 11) were positive for the PVL gene and were multidrug resistant. ST772-MRSA-V was the predominant PVL-positive MRSA clone, although all of them were found to carry the ΦIND772PVL phage in the genome...
November 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/29158480/reversal-of-drug-resistance-by-noscapine-chemo-sensitization-in-docetaxel-resistant-triple-negative-breast-cancer
#6
Ravi Doddapaneni, Ketan Patel, Nusrat Chowdhury, Mandip Singh
Multidrug resistance (MDR) is a major impediment to cancer treatment. Here, for the first time, we investigated the chemo-sensitizing effect of Noscapine (Nos) at low concentrations in conjunction with docetaxel (DTX) to overcome drug resistance of triple negative breast cancer (TNBC). In vitro experiments showed that Nos significantly inhibited proliferation of TNBC wild type (p < 0.01) and drug resistant (p < 0.05) TNBC cells. Nos followed by DTX treatment notably increased the cell viability (~1...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158282/fluconazole-resistant-candida-auris-is-susceptible-to-salivary-histatin-5-killing-and-to-intrinsic-host-defenses
#7
Ruvini U Pathirana, Justin Friedman, Hannah L Norris, Ornella Salvatori, Andrew D McCall, Jason Kay, Mira Edgerton
Candida auris is a newly identified species causing invasive candidemia and candidiasis, and has broad multidrug resistance (MDR) not observed for other pathogenic Candida species. Histatin 5 (Hst 5) is a well-studied salivary cationic peptide with significant antifungal activity against C. albicans, and is an attractive candidate to treat MDR fungi since antimicrobial peptides induce minimal drug resistance. We investigated the susceptibility of C. auris to Hst 5 and neutrophils, two first-line innate defenses in the human host...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158275/a-simplified-derivative-of-human-defensin-5-with-potent-efficiency-against-multidrug-resistant-acinetobacter-baumannii
#8
Cheng Wang, Gaomei Zhao, Song Wang, Yin Chen, Yali Gong, Shilei Chen, Yang Xu, Mengjia Hu, Xinmiao Wang, Hao Zeng, Aiping Wang, Dengqun Liu, Yongping Su, Tianmin Cheng, Fang Chen, Junping Wang
The increasing incidence of multidrug-resistant Acinetobacter baumannii (MDRAb) infections worldwide has necessitated the development of novel antibiotics. Human defensin 5 (HD5) is an endogenous peptide with a complex architecture and antibacterial activity against MDRAb In the present study, we attempted to simplify the structure of HD5 by removing disulfide bonds. We found that the Cys2-4 bond was most indispensable for HD5 to inactivate MDRAb, although the antibacterial activity of the derivative was significantly attenuated...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158274/dissemination-of-multidrug-resistant-proteus-mirabilis-clones-carrying-a-novel-integron-borne-blaimp-1-in-a-tertiary-hospital
#9
Ana Carolina Ramos, Rodrigo Cayô, Cecilia Godoy Carvalhaes, Thomas Jové, Greice Pereira da Silva, Fernanda Maciel Paschoin Sancho, Thomas Chagas-Neto, Eduardo Alexandrino Servolo Medeiros, Ana Cristina Gales
This study aimed to characterize multi-drug resistant P. mirabilis clones carrying a novel class 1 integron-borne blaIMP-1 In1359 was inserted into a large conjugative plasmid that also carried blaCTX-M-2 The production of carbapenemases in Enterobacteriaceae that are intrinsically resistant to polymyxins and tigecycline is very worrisome, representing a serious challenge to clinicians and infection control teams.
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158271/evaluation-of-the-in-vitro-activity-of-ceftaroline-and-comparators-against-s-pneumoniae-isolates-from-u-s-hospitals-results-from-7-years-of-the-aware-surveillance-program-2010-2016
#10
Michael A Pfaller, Rodrigo E Mendes, Leonard R Duncan, Robert K Flamm, Helio S Sader
We evaluated trends in Streptococcus pneumoniae antimicrobial susceptibility in United States hospitals in the 2010--2016 period. A total of 8,768 clinical isolates from 47 medical centers were tested for susceptibility by broth microdilution methods. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) rates decreased from 25.7/12.4% (MDR/XDR) in 2010 to 17.7%/3.6% in 2016. Susceptibility to most comparator antimicrobial agents increased, whereas susceptibility to ceftaroline, levofloxacin, linezolid, and tigecycline remained stable...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158270/in-vitro-activity-of-the-siderophore-cephalosporin-cefiderocol-against-carbapenem-non-susceptible-and-multidrug-resistant-isolates-of-gram-negative-bacilli-collected-worldwide-in-2014-2016
#11
Meredith A Hackel, Masakatsu Tsuji, Yoshinori Yamano, Roger Echols, James A Karlowsky, Daniel F Sahm
The in vitro activity of the investigational siderophore cephalosporin, cefiderocol (formerly S-649266), was determined against a 2014-2016, 52-country, worldwide collection of clinical isolates of carbapenem-non-susceptible Enterobacteriaceae (n=1,022), multidrug-resistant (MDR) Acinetobacter baumannii (n=368), MDR Pseudomonas aeruginosa (n=262), Stenotrophomonas maltophilia (n=217), and Burkholderia cepacia (n=4) using the Clinical and Laboratory Standards Institute (CLSI) standard broth microdilution method...
November 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29158144/ceftolozane-tazobactam-in-the-treatment-of-osteomyelitis-and-skin-and-soft-tissue-infections-due-to-extensively-drug-resistant-pseudomonas-aeruginosa-clinical-and-microbiological-outcomes
#12
B Dietl, I Sánchez, P Arcenillas, E Cuchi, L Gómez, F J González de Molina, L Boix-Palop, J Nicolás, E Calbo
Infections due to multidrug-resistant bacteria (MDRB) are currently a clinical challenge, mainly in elderly patients. Ceftolozane/tazobactam spectrum, safety and efficacy make it an attractive option for MDRB beyond the indications approved to date. We report our experience with ceftolozane/tazobactam in 4 cases of osteomyelitis and 3 skin-soft-tissue infections due to extensively-drug-resistant Pseudomonas aeruginosa.
November 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29157954/activity-of-omadacycline-tested-against-streptococcus-pneumoniae-from-a-global-surveillance-program-2014
#13
M A Pfaller, P R Rhomberg, M D Huband, R K Flamm
The activity of omadacycline and comparators when tested against a subset of Streptococcus pneumoniae from US and European regions of a 2014 global surveillance program (304 isolates) are reported. These MIC results were compared to those obtained when testing S. pneumoniae from 2010 surveillance (1,834 isolates). The omadacycline MIC50/90 for S. pneumoniae (2014) was 0.06/0.06μg/mL, similar to 2010 (MIC50/90, 0.06/0.12μg/mL). The omadacycline MIC90 (0.06-0.12μg/mL) was similar for the penicillin-susceptible, -intermediate, -resistant, multidrug-resistance (MDR; ≥3 classes), and ceftriaxone nonsusceptible subgroups...
October 19, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29157953/chromogenic-detection-procedure-for-the-multidrug-resistant-neonatal-sepsis-associated-clone-staphylococcus-capitis-nrcs-a
#14
Marine Butin, Yann Dumont, Jean-Philippe Rasigade, Patricia Martins Simoes, Louise Hoden, Jean-Charles Picaud, Frédéric Laurent
The multiresistant Staphylococcus capitis clone NRCS-A is a major pathogen in neonates worldwide. We show that NRCS-A grows as mauve colonies with a cream-color halo after a 5-day incubation on MRSA Brilliance 2 agar (Oxoid®). This innovative protocol will ease the screening of clinical and environmental niches of this clone.
October 23, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29157899/epidemiology-of-diabetic-foot-infections-in-a-reference-tertiary-hospital-in-india
#15
Sanjith Saseedharan, Manisa Sahu, Roonam Chaddha, Edwin Pathrose, Arun Bal, Pallavi Bhalekar, Priyadharshini Sekar, Padma Krishnan
INTRODUCTION: The present study attempts to examine the microbial profile and antibiotic susceptibility of diabetic foot infections in the intensive care unit of a tertiary referral centre for diabetic foot. As part of the study, we also attempted to find the prevalence of blaNDM-like gene among carbapenem-resistant gram negative infections. METHODOLOGY: A prospective study of 261 patients with diabetic foot infections was performed during the period between January 2014 and June 2014...
November 1, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29157815/an-efflux-pump-mexab-oprm-of-pseudomonas-aeruginosa-is-associated-with-antibacterial-activity-of-epigallocatechin-3-gallate-egcg
#16
Rashmi Kanagaratnam, Rida Sheikh, Fahad Alharbi, Dong H Kwon
BACKGROUND: Pseudomonas aeruginosa is a notorious multidrug resistant nosocomial pathogen. An efflux pump (MexAB-OprM) is the main contributor to the multidrug resistance in clinical isolates of P. aeruginosa. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound extracted from green tea, exhibits antibacterial activity. It is unclear that molecular details of the antibacterial activity of EGCG, EGCG-effect on antibiotic susceptibility, and clinical relevance of EGCG in bacteria...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157326/relative-resistance-of-the-emerging-fungal-pathogen-candida-auris-and-other-candida-species-to-killing-by-ultraviolet-light
#17
Jennifer L Cadnum, Aaron A Shaikh, Christina T Piedrahita, Annette L Jencson, Emily L Larkin, Mahmoud A Ghannoum, Curtis J Donskey
Mobile ultraviolet-C (UV-C) light room decontamination devices are frequently used as an adjunct to standard cleaning in healthcare facilities, but their efficacy in killing Candida species is not clear. In laboratory testing, the emerging multidrug-resistant Candida auris and 2 other Candida species were significantly less susceptible to killing by UV-C than methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 2017;1-3.
November 21, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29157323/prevalence-and-factors-associated-with-multidrug-resistant-gram-negative-organisms-in-patients-with-spinal-cord-injury
#18
Charlesnika T Evans, Margaret A Fitzpatrick, Makoto M Jones, Stephen P Burns, Linda Poggensee, Swetha Ramanathan, Sherri L LaVela, Nasia Safdar, Katie J Suda
OBJECTIVE Infections caused by multidrug-resistant gram-negative organisms (MDRGNOs) have been increasing every year. The objective of this study was to describe the prevalence of MDRGNOs and factors associated with MDRGNOs in patients with spinal cord injury or disorder (SCI/D). DESIGN Retrospective cohort study. METHODS Department of Veterans Affairs (VA) electronic health record data from 142 VA facilities were evaluated for 19,642 patients with SCI/D. Multivariable cluster-adjusted models were fit to identify factors associated with MDRGNO...
November 21, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29157307/multidrug-resistance-associated-protein-4-is-a-bile-transporter-of-clonorchis-sinensis-simulated-by-in-silico-docking
#19
Fuhong Dai, Won Gi Yoo, Ji-Yun Lee, Yanyan Lu, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong
BACKGROUND: Multidrug resistance-associated protein 4 (MRP4) is a member of the C subfamily of the ABC family of ATP-binding cassette (ABC) transporters. MRP4 regulates ATP-dependent efflux of various organic anionic substrates and bile acids out of cells. Since Clonorchis sinensis lives in host's bile duct, accumulation of bile juice can be toxic to the worm's tissues and cells. Therefore, C. sinensis needs bile transporters to reduce accumulation of bile acids within its body. RESULTS: We cloned MRP4 (CsMRP4) from C...
November 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29156858/risk-factors-for-colistin-associated-nephrotoxicity-and-mortality-in-critically-ill-patients
#20
Hüseyin Özkarakaş, Işıl Köse, Çiler Zincircioğlu, Sibel Ersan, Gürsel Ersan, Nimet Şenoğlu, Şükran Köse, Rıza Hakan Erbay
Background/aim: Colistin is gaining popularity against multidrug-resistant bacteria. The primary concern with colistin is its nephrotoxicity (NT). The aim of this study was to evaluate the incidence and risk factors for NT and to evaluate the risk factors for mortality in the toxicity group. Materials and methods: NT was defined according to the RIFLE criteria. Data of patients who did or did not develop NT were compared. Positive and negative predictive values, risk ratio, and correlation coefficients were calculated...
August 23, 2017: Turkish Journal of Medical Sciences
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