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https://www.readbyqxmd.com/read/27921043/metabolic-vascular-syndrome-new-insights-into-a-multidimensional-network-of-risk-factors-and-diseases
#1
REVIEW
Gerhard H Scholz, Markolf Hanefeld
BACKGROUND: Since 1981, we have used the term metabolic syndrome to describe an association of a dysregulation in lipid metabolism (high triglycerides, low high-density lipoprotein cholesterol, disturbed glucose homeostasis (enhanced fasting and/or prandial glucose), gout, and hypertension), with android obesity being based on a common soil (overnutrition, reduced physical activity, sociocultural factors, and genetic predisposition). We hypothesized that main traits of the syndrome occur early and are tightly connected with hyperinsulinemia/insulin resistance, procoagulation, and cardiovascular diseases...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27920412/leptin-and-calorie-intake-among-different-nicotine-dependent-groups
#2
Muhammad Zulhusni Suhaimi, Zulkefli Sanip, Hamid Jan Jan, Harmy Mohamed Yusoff
BACKGROUND: Exposure to nicotine via tobacco smoking may influence leptin release and decrease food intake among smokers. However, the effect of nicotine exposure on leptin and food intake among different nicotine dependent groups is unclear. OBJECTIVE: We aimed to measure leptin and calorie intake among different nicotine dependent groups. DESIGN: Cross-sectional study. SETTING: Research department in school of medical sciences...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27916646/roles-of-peroxisome-proliferator-activated-receptor-%C3%AE-%C3%AE-in-skeletal-muscle-physiology
#3
REVIEW
Ravikumar Manickam, Walter Wahli
More than two decades of studying peroxisome proliferator-activated receptors (PPARs) has led to an understanding of their implications in various physiological processes that are key for health and disease. All three PPAR isotypes, PPARα, PPARβ/δ, and PPARγ, are activated by a variety of molecules, including fatty acids, eicosanoids and phospholipids, and regulate a spectrum of genes involved in development, lipid and carbohydrate metabolism, inflammation, and proliferation and differentiation of many cell types in different tissues...
December 1, 2016: Biochimie
https://www.readbyqxmd.com/read/27911408/defining-substrate-specificities-for-lipase-and-phospholipase-candidates
#4
Diana X Sahonero-Canavesi, Maritza Zavaleta-Pastor, Lourdes Martínez-Aguilar, Isabel M López-Lara, Otto Geiger
Microorganisms produce a wide spectrum of (phospho)lipases that are secreted in order to make external substrates available for the organism. Alternatively, other (phospho)lipases may be physically associated with the producing organism causing a turnover of intrinsic lipids and frequently giving rise to a remodeling of the cellular membranes. Although potential (phospho)lipases can be predicted with a number of algorithms when the gene/protein sequence is available, experimental proof of the enzyme activities, substrate specificities, and potential physiological functions has frequently not been obtained...
November 23, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27905643/-inverse-association-of-cardiorespiratory-fitness-with-cardiovascular-risk-factors-in-chilean-adults
#5
Carlos Cristi-Montero, Rodrigo Ramírez-Campillo, Cristian Alvarez, Alex Garrido Méndez, María Adela Martínez, Ximena Díaz Martínez, Ana María Leiva, Carlos Salas, Manuel Gutiérrez, Ruth Sanzana-Inzunza, Eliana Durán, Ana María Labraña, Nicolás Aguilar-Farías, Carlos Celis-Morales
BACKGROUND: A high level of cardiorespiratory fitness (CRF) is an important protector against cardiovascular and metabolic diseases. AIM: To explore the association of CRF with several metabolic markers and estimate the variation of these parameters by an increase of 1 MET change in CRF. MATERIAL AND METHODS: Cross-sectional study of 447 adults (56% women) without medical history of cardiometabolic diseases. Physical activity evaluated using accelerometry, body mass index (BMI), blood pressure, blood glucose and insulin and lipid profile were measured...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27904396/moisture-sensitivity-optical-mechanical-and-structural-properties-of-whey-protein-based-edible-films-incorporated-with-rapeseed-oil
#6
Sabina Galus, Justyna Kadzińska
The objective of this work is to study the effect of the rapeseed oil content on the physical properties of whey protein emulsion films. For this purpose, whey protein films with the addition of 0, 1, 2 and 3% of rapeseed oil, and glycerol as a plasticizer were obtained by the casting method. Film-forming emulsions were evaluated and compared using light scattering granulometry. The Sauter mean diameters (d32) of lipid droplets in film-forming solutions showed an increasing trend when increasing the oil volume fractions...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27900199/effects-of-exercise-on-markers-of-oxidative-stress-an-ancillary-analysis-of-the-alberta-physical-activity-and-breast-cancer-prevention-trial
#7
Christine M Friedenreich, Vincent Pialoux, Qinggang Wang, Eileen Shaw, Darren R Brenner, Xavier Waltz, Shannon M Conroy, Rhys Johnson, Christy G Woolcott, Marc J Poulin, Kerry S Courneya
BACKGROUND: Oxidative stress may contribute to cancer aetiology through several mechanisms involving damage to DNA, proteins and lipids leading to genetic mutations and genomic instability. The objective of this study was to determine the effects of aerobic exercise on markers of oxidative damage and antioxidant enzymes in postmenopausal women. METHODS: The Alberta Physical Activity and Breast Cancer Prevention Trial (ALPHA) was a two-centre, two-armed randomised trial of 320 inactive, healthy, postmenopausal women aged 50-74 years...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900165/evaluation-of-cardiovascular-risk-lowering-health-benefits-accruing-from-laboratory-based-community-based-and-exercise-referral-exercise-programmes
#8
R Webb, J E S Thompson, J-S Ruffino, N A Davies, L Watkeys, S Hooper, P M Jones, G Walters, D Clayton, A W Thomas, K Morris, D H Llewellyn, M Ward, J Wyatt-Williams, B J McDonnell
BACKGROUND: To evaluate the ability of community-based exercise programmes to facilitate public participation in exercise and hence improved cardiovascular health, we assessed the respective impacts of: a continuously monitored exercise programme based within our university (study 1); a Valleys Regional Park-facilitated community-based outdoor exercise programme (study 2); a Wales National Exercise Referral Scheme-delivered exercise-referral programme (study 3). METHODS: Biomolecular (monocytic PPARγ target gene expression), vascular haemodynamic (central/peripheral blood pressure, arterial stiffness), clinical (insulin sensitivity, blood lipids) and anthropometric (body mass index, waist circumference, heart rate) parameters were investigated using RT-PCR, applanation tonometry, chemical analysis and standard anthropometric techniques...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27897402/the-impact-of-ageing-physical-activity-and-pre-frailty-on-skeletal-muscle-phenotype-mitochondrial-content-and-intramyocellular-lipids-in-men
#9
Félix St-Jean-Pelletier, Charlotte H Pion, Jean-Philippe Leduc-Gaudet, Nicolas Sgarioto, Igor Zovilé, Sébastien Barbat-Artigas, Olivier Reynaud, Feras Alkaterji, François C Lemieux, Alexis Grenon, Pierrette Gaudreau, Russell T Hepple, Stéphanie Chevalier, Marc Belanger, José A Morais, Mylène Aubertin-Leheudre, Gilles Gouspillou
BACKGROUND: The exact impact of ageing on skeletal muscle phenotype and mitochondrial and lipid content remains controversial, probably because physical activity, which greatly influences muscle physiology, is rarely accounted for. The present study was therefore designed to investigate the effects of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, and mitochondrial and intramyocellular lipid content in men. METHODS: Recreationally active young adult (20-30 yo; YA); active (ACT) and sedentary (SED) middle-age (50-65 yo; MA-ACT and MA-SED); and older (65 + yo; 65 + ACT and 65 + SED) and pre-frail older (65 + PF) men were recruited...
September 2, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27895666/cardiometabolic-risk-in-hyperlipidemic-men-and-women
#10
Michael Leutner, Christian Göbl, Alice Wielandner, Eleonora Howorka, Marlies Prünner, Latife Bozkurt, Jürgen Harreiter, Helmut Prosch, Oliver Schlager, Silvia Charwat-Resl, Alexandra Kautzky-Willer
Objective. The aim of this study was to evaluate sex specific differences of metabolic and clinical characteristics of treated hyperlipidemic men and women (HL-men and HL-women). Methods. In this study vascular and metabolic characteristics of 35 HL-women and 64 HL-men were assessed. In addition a sex specific analysis of metabolic and nutritional habits of HL-patients with prediabetes (HL-IGR) was done. Results. HL-women were older and had favourable concentrations of high density lipoprotein cholesterol (HDL-cholesterol), triglycerides (TG), and triglyceride/HDL-cholesterol ratio (TG/HDL-ratio) but were also shown to have higher concentrations of lipoprotein-a compared to HL-men...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27894336/curcumin-and-long-chain-omega-3-polyunsaturated-fatty-acids-for-prevention-of-type-2-diabetes-cop-d-study-protocol-for-a-randomised-controlled-trial
#11
Rohith N Thota, Shamasunder H Acharya, Kylie A Abbott, Manohar L Garg
BACKGROUND: Lifestyle interventions, including increase in physical activity and dietary counselling, have shown the ability to prevent type 2 diabetes (T2D) in high-risk state individuals, but the prevalence is still skyrocketing in Australia, in line with global prevalence. Currently, no medicines are approved by the Therapeutic Goods Administration in Australia for the management of prediabetes. Therefore, there is a need of developing a safer, biologically efficacious and cost-effective alternative for delaying the transition of individual health state from prediabetes into T2D...
November 29, 2016: Trials
https://www.readbyqxmd.com/read/27893563/resistance-training-improves-muscle-function-and-cardiometabolic-risks-but-not-quality-of-life-in-older-people-with-type-2-diabetes-mellitus-a-randomized-controlled-trial
#12
Ping-Lun Hsieh, Chin-Hsiao Tseng, Yufeng Jane Tseng, Wei-Shiung Yang
BACKGROUND AND PURPOSE: In older people with type 2 diabetes mellitus (T2DM), the effects of aging and T2DM may compromise the function of skeletal muscle, deteriorate metabolic status, and jeopardize physical performance, aerobic capacity, and quality of life (QoL). The purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) on muscle function, physical performance, cardiometabolic risks, and QoL in older people with T2DM. METHODS: This study was a randomized controlled trial that employed block randomization, assessor blinding, and the intention-to-treat principle...
November 23, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27893473/concurrent-training-promoted-sustained-anti-atherogenic-benefits-in-the-fasting-plasma-triacylglycerolemia-of-postmenopausal-women-at-1-year-follow-up
#13
Fabrício E Rossi, Tiego A Diniz, Ana Claudia S Fortaleza, Lucas M Neves, Malena R Picolo, Paula A Monteiro, Camila Buonani, Fábio S Lira, Ismael F Freitas
The aim of this study was to compare the effects of aerobic and concurrent training (aerobic plus strength training) on the lipid profiles of normotriacylglycerolemic and hypertriacylglycerolemic postmenopausal women and to verify whether the benefits of aerobic and concurrent training were sustained after 1 year. Total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), Triacylglycerol (TAG) and glucose were assessed in 46 normotriacylglycerolemic (TAG<150 mg/dL) postmenopausal women divided into three groups: Aerobic Training (AT), Concurrent Training (CT) and a Control Group (CG)...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27892780/associations-between-prolonged-sedentary-time-and-breaks-in-sedentary-time-with-cardiometabolic-risk-in-10-14-year-old-children-the-happy-study
#14
Daniel P Bailey, Sarah J Charman, Thomas Ploetz, Louise A Savory, Catherine J Kerr
This study examines the association between prolonged sedentary time and breaks in sedentary time with cardiometabolic risk in 10-14-year-old children. This cross-sectional design study analysed accelerometry-determined sedentary behaviour and physical activity collected over 7 days from 111 (66 girls) UK schoolchildren. Objective outcome measures included waist circumference, fasting lipids, fasting glucose, blood pressure, and cardiorespiratory fitness. Logistic regression was used for the main data analysis...
November 28, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27889304/distinct-membrane-properties-are-differentially-influenced-by-cardiolipin-content-and-acyl-chain-composition-in-biomimetic-membranes
#15
Edward Ross Pennington, Amy Fix, E Madison Sullivan, David A Brown, Anthony Kennedy, Saame Raza Shaikh
Cardiolipin (CL) has a critical role in maintaining mitochondrial inner membrane structure. In several conditions such as heart failure and aging, there is loss of CL content and remodeling of CL acyl chains, which are hypothesized to impair mitochondrial inner membrane biophysical organization. Therefore, this study discriminated how CL content and acyl chain composition influenced select properties of simple and complex mitochondrial mimicking model membranes. We focused on monolayer excess area/molecule (a measure of lipid miscibility), bilayer phase transitions, and microdomain organization...
November 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27887661/biochemical-and-proteomic-analyses-of-the-physiological-response-induced-by-individual-housing-in-gilts-provide-new-potential-stress-markers
#16
Anna Marco-Ramell, Laura Arroyo, Raquel Peña, Raquel Pato, Yolanda Saco, Lorenzo Fraile, Emøke Bendixen, Anna Bassols
BACKGROUND: The objective assessment of animal stress and welfare requires proper laboratory biomarkers. In this work, we have analyzed the changes in serum composition in gilts after switching their housing, from pen to individual stalls, which is generally accepted to cause animal discomfort. RESULTS: Blood and saliva samples were collected a day before and up to four days after changing the housing system. Biochemical analyses showed adaptive changes in lipid and protein metabolism after the housing switch, whereas cortisol and muscular markers showed a large variability between animals...
November 25, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27885532/whey-protein-supplementation-enhances-body-fat-and-weight-loss-in-women-long-after-bariatric-surgery-a-randomized-controlled-trial
#17
Daniela Lopes Gomes, Milene Moehlecke, Fernanda Bassan Lopes da Silva, Eliane Said Dutra, Beatriz D'Agord Schaan, Kenia Mara Baiocchi de Carvalho
BACKGROUND: The ideal nutritional approach for weight regain after bariatric surgery remains unclear. OBJECTIVE: The objective of this study is to assess the effect of whey protein supplementation on weight loss and body composition of women who regained weight 24 or more months after bariatric surgery. METHODS: This is a 16-week open-label, parallel-group, randomized controlled trial of women who regained at least 5 % of their lowest postoperative weight after a Roux-en-Y gastric bypass (RYGB)...
November 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27882212/resveratrol-and-exercise
#18
Saltuk Bugra Baltaci, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Although it is recommended for a healthy lifestyle, moderate exercise is known to lead to oxidative stress, inflammation and muscle injury. Hence there are efforts to develop dietary strategies to counter the oxidative stress caused by physical activity. Recently, there has been an interest in the capability of resveratrol (RES) to modulate physical performance and prevent oxidative stress. Despite the inconsistency among reports regarding the topic, it has been suggested that RES delays fatigue by hindering lipid peroxidation...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27881102/associations-of-sedentary-behavior-and-physical-activity-with-physical-measurements-and-dyslipidemia-in-school-age-children-a-cross-sectional-study
#19
Wei Zheng, Yun Chen, Ai Zhao, Yong Xue, Yingdong Zheng, Zhishen Mu, Peiyu Wang, Yumei Zhang
BACKGROUND: Physical activity and sedentary behavior are common factors influencing cardiovascular health. However, how school and leisure-time activity/sedentary behavior are associated with physical fitness and blood lipid levels in primary school children in consideration of gender disparity remains unclear. METHODS: Data was obtained from a health and nutrition survey on primary school children from nine areas in China. The association between physical activities/sedentary behaviors (school and leisure-time physical activity levels, screen time, and other sedentary behaviors) and anthropometric measurements/prevalence of dyslipidemia were examined by multilevel analysis (the individual level, class level, grade level, and investigation area level) adjusted for age, energy intake and family income...
November 24, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27881065/lipids-at-the-cross-road-of-autoimmunity-in-multiple-sclerosis
#20
Marcella Reale, Silvia Sánchez-Ramón
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS) characterized by demyelination and neurodegeneration, driven by a Th17/Th1-immune response, which afflicts mainly young women. Although MS causes are not completely known, it is notorious that the disease is characterized by an extended focal degradation of the myelin sheath, with ulterior axon and neuronal damage. Lipid molecules play a main dual role in MS, both as target molecules of myelin destruction and as mediators of inflammation...
November 22, 2016: Current Medicinal Chemistry
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