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lipids and physical activity

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https://www.readbyqxmd.com/read/28918545/increased-postharvest-life-of-tomlox-b-silenced-mutants-of-tomato-solanum-lycopersicum-var-ta234
#1
Elizabeth León-García, Gilber Vela-Gutiérrez, Oscar A Del Ángel-Coronel, Cristobal Torres-Palacios, Javier De La Cruz-Medina, Miguel A Gómez-Lim, Hugo Sergio García
A healthy lifestyle includes fruits and vegetables consumption. Tomato is one of the most consumed vegetables, although it is susceptible to physical damage through postharvest handling, thus leading to important losses. Softening is an important variable during tomato ripening; excessive softening is undesirable and leads to postharvest losses. TomloxB plays an important role in ripening, mainly in the loss of cellular integrity caused by fatty acids released from the lipid matrix of membranes that initiate oxidative deterioration, which is in turn carried into senescence...
September 16, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28917242/comprehensive-school-based-intervention-to-control-overweight-and-obesity-in-china-a-cluster-randomized-controlled-trial
#2
Haiquan Xu, Yanping Li, Qian Zhang, Xiaoqi L Hu, Ailing Liu, Songming Du, Tingyu Li, Hongwei Guo, Ying Li, Guifa Xu, Weijia Liu, Jun Ma, Guansheng Ma
BACKGROUND AND OBJECTIVES: With prevalence of childhood obesity increasing rapidly, developing of effective and sustainable intervention strategies is becoming more and more important for the prevention of childhood obesity in China. A trial was developed to evaluate the effect of comprehensive school-based intervention on childhood obesity. METHODS AND STUDY DESIGN: A multi-center cluster randomized controlled trial was conducted among urban children (n=9,867) aged 6-13 years in 38 primary schools from six large cities...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917060/lipids-and-ions-traverse-the-membrane-by-the-same-physical-pathway-in-the-nhtmem16-scramblase
#3
Tao Jiang, Kuai Yu, H Criss Hartzell, Emad Tajkhorshid
From bacteria to mammals, different phospholipid species are segregated between the inner and outer leaflets of the plasma membrane by ATP-dependent lipid transporters. Disruption of this asymmetry by ATP-independent phospholipid scrambling is important in cellular signaling, but its mechanism remains incompletely understood. Using MD simulations coupled with experimental assays, we show that the surface hydrophilic transmembrane cavity exposed to the lipid bilayer on the fungal scramblase nhTMEM16 serves as the pathway for both lipid translocation and ion conduction across the membrane...
September 16, 2017: ELife
https://www.readbyqxmd.com/read/28915863/lifestyle-intervention-to-improve-quality-of-life-and-prevent-weight-gain-after-renal-transplantation-design-of-the-active-care-after-transplantation-act-randomized-controlled-trial
#4
Gerald Klaassen, Dorien M Zelle, Gerjan J Navis, Desie Dijkema, Frederike J Bemelman, Stephan J L Bakker, Eva Corpeleijn
BACKGROUND: Low physical activity and reduced physical functioning are common after renal transplantation, resulting in a reduced quality of life. Another common post-transplantation complication is poor cardio-metabolic health, which plays a main role in long-term outcomes in renal transplant recipients (RTR). It is increasingly recognized that weight gain in the first year after transplantation, especially an increase in fat mass, is a highly common contributor to cardio-metabolic risk...
September 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28913755/management-and-clinical-outcome-of-stable-coronary-artery-disease-in-austria-results-from-5%C3%A2-years-of-the-clarify-registry
#5
Irene M Lang, Roza Badr-Eslam, Nicola Greenlaw, Robin Young, Philippe Gabriel Steg
BACKGROUND: The population of patients with established coronary artery disease (CAD) is growing because of an improvement in outcomes and survival from acute disease episodes. Nevertheless, these patients remain at high risk of cardiovascular events. Thus, CAD management is important in prevention of disease progression. The objective of this analysis was to describe disease management and clinical outcome of Austrian outpatients with stable CAD over 5 years by using data from the international CLARIFY registry...
September 14, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28912752/disparities-in-cardiovascular-disease-and-type-2-diabetes-risk-factors-in-blacks-and-whites-dissecting-racial-paradox-of-metabolic-syndrome
#6
REVIEW
Kwame Osei, Trudy Gaillard
Cardiovascular diseases (CVD) remain as the leading cause of mortality in the western world and have become a major health threat for developing countries. There are several risk factors that account for the CVD and the associated mortality. These include genetics, type 2 diabetes (T2DM), obesity, physical inactivity, hypertension, and abnormal lipids and lipoproteins. The constellation of these risk factors has been termed metabolic syndrome (MetS). MetS varies among racial and ethnic populations. Thus, race and ethnicity account for some of the differences in the MetS and the associated CVD and T2DM...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28912721/physical-and-chemical-processes-and-the-morphofunctional-characteristics-of-human-erythrocytes-in-hyperglycaemia
#7
Victor V Revin, Natalia A Klenova, Natalia V Gromova, Igor P Grunyushkin, Ilia N Solomadin, Alexander Y Tychkov, Anastasia A Pestryakova, Anna V Sadykhova, Elvira S Revina, Ksenia V Prosnikova, Jean-Christophe Bourdon, Nikolai Zhelev
Background: This study examines the effect of graduated hyperglycaemia on the state and oxygen-binding ability of hemoglobin, the correlation of phospholipid fractions and their metabolites in the membrane, the activity of proteolytic enzymes and the morphofunctional state of erythrocytes. Methods: Conformational changes in the molecule of hemoglobin were determined by Raman spectroscopy. The structure of the erythrocytes was analyzed using laser interference microscopy (LIM). To determine the activity of NADN-methemoglobinreductase, we used the P...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28911818/anti-fatigue-activity-of-a-lachnum-polysaccharide-and-its-carboxymethylated-derivative-in-mice
#8
Maheen Mahwish Surhio, Yufen Wang, Shi Fang, Jinglei Li, Ming Ye
The present study was designed to evaluate the anti-fatigue activity of an exopolysaccharide LEP-1b and its carboxymethylated derivative CLEP-1b from a Lachnum sp. Carboxymethylation was confirmed through FT-IR and (13)C NMR spectroscopies, which showed that the (-CH2COOH) group was attached to an oxygen (O) atom of the hydroxyl group on (C-3) of LEP-1b. Each treatment group LEP-1b and CLEP-1b at doses (50, 100, 200mg/kg, respectively) ameliorated physical fatigue and extended exhaustive swimming time in mice...
July 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28911527/cellular-models-for-the-evaluation-of-the-antiobesity-effect-of-selected-phytochemicals-from%C3%A2-food-and-herbs
#9
REVIEW
Yen-Chen Tung, Pei-Hsuan Hsieh, Min-Hsiung Pan, Chi-Tang Ho
Dietary phytochemicals from food and herbs have been studied for their health benefits for a long time. The incidence of obesity has seen an incredible increase worldwide. Although dieting, along with increased physical activity, seems an easy method in theory to manage obesity, it is hard to apply in real life. Obesity treatment drugs and surgery are not successful or targeted for everyone and can have significant side effects. This low rate of success is the major reason that the overweight as well as the pharmaceutical industry seek alternative methods, including phytochemicals...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911148/age-related-anabolic-resistance-of-myofibrillar-protein-synthesis-is-exacerbated-in-obese-inactive-individuals
#10
Benoit Smeuninx, James Mckendry, Daisy Wilson, Una Martin, Leigh Breen
Context: A diminished muscle anabolic response to protein nutrition may underpin age-associated muscle loss. Objective: To determine how chronological and biological aging influence myofibrillar protein synthesis (MyoPS). Design: Cross-sectional comparison. Setting: Clinical research facility. Participants: Ten older lean [OL: 71.7 ± 6 years; body mass index (BMI) ≤25 kg ⋅ m-2], 7 older obese (OO: 69...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28903625/radioprotective-activity-of-curcumin-encapsulated-liposomes-against-genotoxicity-caused-by-gamma-cobalt-60-irradiation-in-human-blood-cells
#11
Minh-Hiep Nguyen, Pham Ngoc Duy, Bingxue Dong, Thi-Huynh-Nga Nguyen, Chi-Bao Bui, Kunn Hadinoto
PURPOSE: While the radioprotective activity of curcumin against genotoxicity has been well established, its poor oral bioavailability has limited its successful clinical applications. Nanoscale formulations, including liposomes, have been demonstrated to improve curcumin bioavailability. The objective of the present work was (1) to prepare and characterize curcumin-encapsulated liposomes (i.e. size, colloidal stability, encapsulation efficiency, and payload), and (2) subsequently to evaluate their radioprotective activity against genotoxicity in human blood cells caused by Gamma Cobalt-60 irradiation...
September 14, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28901674/atrial-fibrillation-is-associated-with-cognitive-decline-in-stroke-free-subjects-the-troms%C3%A3-study
#12
Sweta Tiwari, Maja-Lisa Løchen, Bjarne K Jacobsen, Laila A Hopstock, Audhild Nyrnes, Inger Njølstad, Ellisiv B Mathiesen, Kjell A Arntzen, Jocasta Ball, Simon Stewart, Tom Wilsgaard, Henrik Schirmer
BACKGROUND: Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men. METHODS: We included 4983 participants (57% women) from the 5(th) survey of the Tromsø Study (Tromsø 5, 2001), of whom 2491 also participated in 6(th) survey (Tromsø 6, 2007-08). Information about age, education, blood pressure, body mass index, lipids, smoking, coffee consumption, physical activity, depression, coronary and valvular heart disease, heart failure and diabetes was obtained at baseline...
September 13, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28901220/biomarkers-of-cardiometabolic-health-are-associated-with-body-composition-characteristics-but-not-physical-activity-in-persons-with-spinal-cord-injury
#13
Tom E Nightingale, Jean-Philippe Walhin, Dylan Thompson, James Lj Bilzon
Objective To examine (i) the associations between physical activity dimensions, cardiorespiratory fitness and body composition and, (ii) the associations between physical activity dimensions, cardiorespiratory fitness, body composition and biomarkers of cardiometabolic health in persons with spinal cord injury (SCI). Methods A cross-sectional prospective cohort study with 7-day follow-up was conducted. Body composition, cardiorespiratory fitness and biomarkers of cardiometabolic health were measured in thirty-three participants with SCI (> 1 year post injury)...
September 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28899482/enzymatic-synthesis-of-chlorogenic-acid-glucoside-using-dextransucrase-and-its-physical-and-functional-properties
#14
Seung-Hee Nam, Jin-A Ko, Woojin Jun, Young-Jung Wee, Marie K Walsh, Kwang-Yeol Yang, Jin-Ho Choi, Jon-Bang Eun, Jeong Choi, Young-Min Kim, Songhee Han, Thi Thanh Hanh Nguyen, Doman Kim
Chlorogenic acid, a major polyphenol in edible plants, possesses strong antioxidant activity, anti-lipid peroxidation and anticancer effects. It used for industrial applications; however, this is limited by its instability to heat or light. In this study, we for the first time synthesized chlorogenic acid glucoside (CHG) via transglycosylation using dextransucrase from Leuconostoc mesenteroides and sucrose. CHG was purified and its structure determined by nuclear magnetic resonance and matrix-associated laser desorption ionization-time-of-flight mass spectroscopy...
December 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28892741/effect-of-diet-with-omega-3-in-basal-brain-electrical-activity-and-during-status-epilepticus-in-rats
#15
Daniella Tavares Pessoa, Eva Luana Almeida da Silva, Edbhergue Ventura Lola Costa, Romildo Albuquerque Nogueira
Western diets are high in saturated fat and low in omega-3. Certain animals cannot produce omega-3 from their own lipids, making it necessary for it to be acquired from the diet. However, omega-3s are important components of the plasma membrane, and altering their proportions can promote physical and chemical alterations in the membranes, which may modify neuronal excitability. These alterations occur in healthy individuals, as well as in patients with epilepsy who are more sensitive to changes in brain electrical activity...
September 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28892239/impact-of-physical-activity-on-obesity-and-lipid-profile-of-adults-with-intellectual-disability
#16
Krystyna Gawlik, Anna Zwierzchowska, Diana Celebańska
INTRODUCTION: This study assessed overweight, obesity and lipid profiles in adults with intellectual disability and compared these metrics with their physical activity. MATERIALS AND METHOD: Basic somatic parameters, lipid profile and weekly physical activity were examined in 27 adults with moderate intellectual disability. Chi-square independence tests and Pearson's linear correlation coefficients were used. RESULTS: The participants had excess body mass, excess body fat and abdominal obesity...
September 11, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28891932/inadequate-vitamin-c-status-in-prediabetes-and-type-2-diabetes-mellitus-associations-with-glycaemic-control-obesity-and-smoking
#17
Renée Wilson, Jinny Willis, Richard Gearry, Paula Skidmore, Elizabeth Fleming, Chris Frampton, Anitra Carr
Vitamin C (ascorbate) is an essential micronutrient in humans, being required for a number of important biological functions via acting as an enzymatic cofactor and reducing agent. There is some evidence to suggest that people with type 2 diabetes mellitus (T2DM) have lower plasma vitamin C concentrations compared to those with normal glucose tolerance (NGT). The aim of this study was to investigate plasma vitamin C concentrations across the glycaemic spectrum and to explore correlations with indices of metabolic health...
September 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28891084/structured-advice-provided-by-a-dietitian-increases-adherence-of-consumers-to-diet-and-lifestyle-changes-and-lowers-blood-low-density-lipoprotein-ldl-cholesterol-the-increasing-adherence-of-consumers-to-diet-lifestyle-changes-to-lower-ldl-cholesterol-act-randomised
#18
T E Sialvera, A Papadopoulou, S P Efstathiou, E A Trautwein, R T Ras, N Kollia, P Farajian, G Goumas, I Dimakopoulos, K Papavasiliou, A Koutsouri, A Zampelas
BACKGROUND: Evidence from healthcare professionals suggest that consumer compliance to healthy diet and lifestyle changes is often poor. The present study investigated the effect of advice provided by a physician or dietitian on consumer adherence to these measures combined with consuming foods with added plant sterols (PS) with the aim of lowering low-density lipoprotein cholesterol (LDL-C). METHODS: One hundred mildly-to-moderately hypercholesterolaemic individuals were enrolled into a parallel, randomised, placebo-controlled study...
September 11, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28890218/serum-perfluoroalkyl-substances-and-cardiometabolic-consequences-in-adolescents-exposed-to-the-world-trade-center-disaster-and-a-matched-comparison-group
#19
Tony T Koshy, Teresa M Attina, Akhgar Ghassabian, Joseph Gilbert, Lauren K Burdine, Michael Marmor, Masato Honda, Dinh Binh Chu, Xiaoxia Han, Yongzhao Shao, Kurunthachalam Kannan, Elaine M Urbina, Leonardo Trasande
BACKGROUND: Large amounts of various chemical contaminants, including perfluoroalkyl substances (PFASs), were released at the time of the World Trade Center (WTC) disaster. Thousands of children who lived and/or attended school near the disaster site were exposed to these substances but few studies have examined the possible consequences related to these exposures. OBJECTIVES: To examine the relationship of PFASs serum levels with cardiometabolic profile in children and adolescents enrolled in the World Trade Center Health Registry (WTCHR) and a matched comparison group...
September 7, 2017: Environment International
https://www.readbyqxmd.com/read/28889276/thallium-toxicity-general-issues-neurological-symptoms-and-neurotoxic-mechanisms
#20
Laura Osorio-Rico, Abel Santamaria, Sonia Galván-Arzate
Thallium (Tl(+)) is a ubiquitous natural trace metal considered as the most toxic among heavy metals. The ionic ratio of Tl(+) is similar to that of potassium (K(+)), therefore accounting for the replacement of the latter during enzymatic reactions. The principal organelle damaged after Tl(+) exposure is mitochondria. Studies on the mechanisms of Tl(+) include intrinsic pathways altered and changes in antiapoptotic and proapoptotic proteins, cytochrome c, and caspases. Oxidative damage pathways increase after Tl(+) exposure to produce reactive oxygen species (ROS), changes in physical properties of the cell membrane caused by lipid peroxidation, and concomitant activation of antioxidant mechanisms...
2017: Advances in Neurobiology
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