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lipids and physical activity

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https://www.readbyqxmd.com/read/28630872/effect-of-regular-aerobic-activity-in-young-healthy-athletes-on-profile-of-endothelial-function-and-platelet-activity
#1
Katarzyna Podgórska, Arkadiusz Derkacz, Ewa Szahidewicz-Krupska, Jakub Jasiczek, Piotr Dobrowolski, Aneta Radziwon-Balicka, Robert Skomro, Andrzej Szuba, Grzegorz Mazur, Adrian Doroszko
The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18-40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation (FMD) was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid (ASA-75 mg/day) for 4 days...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28625872/decreased-enteritis-resistance-ability-by-dietary-low-or-excess-levels-of-lipids-through-impairing-the-intestinal-physical-and-immune-barriers-function-of-young-grass-carp-ctenopharyngodon-idella
#2
Lin Feng, Pei-Jun Ni, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xu Tang, He-Qun Shi, Xiao-Qiu Zhou
The current study explores the hypothesis that low or excess levels of lipids decrease the enteritis resistance ability through impairing the intestinal physical and immune barrier function of young grass carp (Ctenopharyngodon idella). A total of 540 young grass carp with an average initial weight of 261.41 ± 0.53 g were fed diets containing six graded levels of lipids at 5.9, 21.4, 36.0, 50.2, 66.6 and 80.1 g/kg for 8 weeks. After that, a challenge trial was conducted by injection of Aeromonas hydrophila over 2 weeks...
June 15, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28624659/surface-engineering-of-solid-lipid-nanoparticle-assemblies-by-methyl-%C3%AE-d-mannopyranoside-for-the-active-targeting-to-macrophages-in-anti-tuberculosis-inhalation-therapy
#3
Eleonora Maretti, Luca Costantino, Cecilia Rustichelli, Eliana Leo, Maria Antonietta Croce, Francesca Buttini, Eleonora Truzzi, Valentina Iannuccelli
This study describes the development of new mannosylated Solid Lipid Nanoparticle assemblies (SLNas) delivering rifampicin for an inhaled treatment of tuberculosis. SLNas were surface engineered with mannose residues to recognize mannose receptors located on infected alveolar macrophages and facilitate cell internalization. Two sets of SLNas were produced by the melt emulsifying technique using biocompatible lipid components, i.e. cholesteryl myristate combined with palmitic acid (PA set) or tripalmitin (TP set), in the presence of the targeting moiety, methyl α-d-mannopyranoside...
June 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28620545/cardiovascular-risk-factors-among-women-with-self-reported-infertility
#4
Shruthi Mahalingaiah, Fangui Sun, J Jojo Cheng, Erika T Chow, Kathryn L Lunetta, Joanne M Murabito
BACKGROUND: Amongst women with certain types of ovulatory disorder infertility, the studies are conflicting whether there is an increased risk of long-term cardiovascular disease risk. This paper evaluates the associations of several CVD risk factors among Framingham women with self-reported infertility. METHODS: Women who completed the Framingham Heart Study Third Generation and Omni Cohort 2 Exam 2 (2008-2011), and reported on past history of infertility and current cardiovascular disease status were included in this cross-sectional study...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28620071/multiancestry-study-of-gene-lifestyle-interactions-for-cardiovascular-traits-in-610-475-individuals-from-124-cohorts-design-and-rationale
#5
D C Rao, Yun J Sung, Thomas W Winkler, Karen Schwander, Ingrid Borecki, L Adrienne Cupples, W James Gauderman, Kenneth Rice, Patricia B Munroe, Bruce M Psaty
BACKGROUND: Several consortia have pursued genome-wide association studies for identifying novel genetic loci for blood pressure, lipids, hypertension, etc. They demonstrated the power of collaborative research through meta-analysis of study-specific results. METHODS AND RESULTS: The Gene-Lifestyle Interactions Working Group was formed to facilitate the first large, concerted, multiancestry study to systematically evaluate gene-lifestyle interactions. In stage 1, genome-wide interaction analysis is performed in 53 cohorts with a total of 149 684 individuals from multiple ancestries...
June 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28620070/prediction-of-adult-dyslipidemia-using-genetic-and-childhood-clinical-risk-factors-the-cardiovascular-risk-in-young-finns-study
#6
Joel Nuotio, Niina Pitkänen, Costan G Magnussen, Marie-Jeanne Buscot, Mikko S Venäläinen, Laura L Elo, Eero Jokinen, Tomi Laitinen, Leena Taittonen, Nina Hutri-Kähönen, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Jorma S Viikari, Markus Juonala, Olli T Raitakari
BACKGROUND: Dyslipidemia is a major modifiable risk factor for cardiovascular disease. We examined whether the addition of novel single-nucleotide polymorphisms for blood lipid levels enhances the prediction of adult dyslipidemia in comparison to childhood lipid measures. METHODS AND RESULTS: Two thousand four hundred and twenty-two participants of the Cardiovascular Risk in Young Finns Study who had participated in 2 surveys held during childhood (in 1980 when aged 3-18 years and in 1986) and at least once in a follow-up study in adulthood (2001, 2007, and 2011) were included...
June 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28614350/ranking-and-characterization-of-established-bmi-and-lipid-associated-loci-as-candidates-for-gene-environment-interactions
#7
Dmitry Shungin, Wei Q Deng, Tibor V Varga, Jian'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P Morris, Nita G Forouhi, Cecilia Lindgren, Patrik K E Magnusson, Nancy L Pedersen, Göran Hallmans, Audrey Y Chu, Anne E Justice, Mariaelisa Graff, Thomas W Winkler, Lynda M Rose, Claudia Langenberg, L Adrienne Cupples, Paul M Ridker, Nicholas J Wareham, Ken K Ong, Ruth J F Loos, Daniel I Chasman, Erik Ingelsson, Tuomas O Kilpeläinen, Robert A Scott, Reedik Mägi, Guillaume Paré, Paul W Franks
Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm). Correlations between Pv and Pm were stronger for SNPs with established marginal effects (Spearman's ρ = 0...
June 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28610721/cationic-liposomal-vectors-incorporating-a-bolaamphiphile-for-oligonucleotide-antimicrobials
#8
Marianna Mamusa, Leopoldo Sitia, Francesco Barbero, Angels Ruyra, Teresa Díaz Calvo, Costanza Montis, Ana Gonzalez-Paredes, Grant N Wheeler, Christopher J Morris, Michael McArthur, Debora Berti
Antibacterial resistance has become a serious crisis for world health over the last few decades, so that new therapeutic approaches are strongly needed to face the threat of resistant infections. Transcription factor decoys (TFD) are a promising new class of antimicrobial oligonucleotides with proven in vivo activity when combined with a bolaamphiphilic cationic molecule, 12-bis-THA. These two molecular species form stable nanoplexes which, however, present very scarce colloidal stability in physiological media, which poses the challenge of drug formulation and delivery...
June 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28607329/influence-of-long-term-physical-activity-on-pcsk9-hdl-ldl-c-and-lp-a-a-prospective-observational-trial
#9
Michael Sponder, Ioana-Alexandra Campean, Daniel Dalos, Michael Emich, Monika Fritzer-Szekeres, Brigitte Litschauer, Jutta Bergler-Klein, Senta Graf, Jeanette Strametz-Juranek
INTRODUCTION    Since PCSK9 (proprotein convertase subtilisin/kexin type 9)-inhibitors were brought to market, the interest in PCSK9 metabolism has increased dramatically.  OBJECTIVES    This study investigates prospectively the influence of long-term physical activity on PCSK9, high and low-density lipoprotein cholesterol (HDL-C/LDL-C) and lipoprotein a [Lp(a)]. PATIENTS AND METHODS    109 subjects were recruited and instructed to increase their sport pensum by 75 minutes/week of vigorous or 150 minutes/week of moderate intensity endurance training (or a mixture) within the calculated training pulse for 8 months...
June 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28606714/effect-of-physical-exercise-on-brain-and-lipid-metabolism-in-mouse-models-of-multiple-sclerosis
#10
REVIEW
Léo Houdebine, Cristina Anna Gallelli, Marialetizia Rastelli, Nirmal Kumar Sampathkumar, Julien Grenier
Multiple sclerosis (MS) is a central nervous demyelinating disease characterized by cyclic loss and repair of myelin sheaths associated with chronic inflammation and neuronal loss. This degenerative pathology is accompanied by modified levels of oxysterols (oxidative derivatives of cholesterol, implicated in cholesterol metabolism), highlighted in the brain, blood and cerebrospinal fluid of MS patients. The pathological accumulation of such derivatives is thought to participate in the onset and progression of the disease through their implication in inflammation, oxidative stress, demyelination and neurodegeneration...
June 9, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28603518/microbial-extracellular-polymeric-substances-epss-in-ocean-systems
#11
REVIEW
Alan W Decho, Tony Gutierrez
Microbial cells (i.e., bacteria, archaea, microeukaryotes) in oceans secrete a diverse array of large molecules, collectively called extracellular polymeric substances (EPSs) or simply exopolymers. These secretions facilitate attachment to surfaces that lead to the formation of structured 'biofilm' communities. In open-water environments, they also lead to formation of organic colloids, and larger aggregations of cells, called 'marine snow.' Secretion of EPS is now recognized as a fundamental microbial adaptation, occurring under many environmental conditions, and one that influences many ocean processes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28601691/effects-of-a-nurse-led-transitional-care-program-on-clinical-outcomes-health-related-knowledge-physical-and-mental-health-status-among-chinese-patients-with-coronary-artery-disease-a-randomized-controlled-trial
#12
Pan Zhang, Yu-Ding Hu, Feng-Mei Xing, Chang-Zai Li, Wang-Feng Lan, Xiao-Li Zhang
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality among adults worldwide, including China. After a hospital stay, transitional care could help to ensure improved patient care and outcomes, and reduce Medicare costs. Nevertheless, the results of the existing transitional care are not always satisfactory and our knowledge of how to perform effective transitional care for patients with coronary artery disease is limited in mainland China. OBJECTIVES: To examine the effectiveness of a nurse-led transitional care program on clinical outcomes, health-related knowledge, and physical and mental health status among Chinese patients with coronary artery disease...
April 14, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28596107/a-novel-function-for-glucocerebrosidase-as-a-regulator-of-sterylglucoside-metabolism
#13
REVIEW
Hisako Akiyama, Yoshio Hirabayashi
BACKGROUND: Sterols are major cell membrane lipids, and in many organisms they are modified with glucose to generate sterylglucosides. Glucosylation dramatically changes the functional properties of sterols. The formation of sterylglucosides from sterols in plants, fungi, and bacteria uses UDP-glucose as a glucose donor. By contrast, sterylglucoside biosynthesis in mammals is catalyzed by the transglucosylation activity of glucocerebrosidases, with glucosylceramide acting as the glucose donor...
June 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28593390/origin-differentiation-and-functional-ultrastructure-of-egg-envelopes-in-the-cestode-echinococcus-multilocularis-leuckart-1863-cyclophyllidea-taeniidae
#14
Zdzisław Świderski, Jordi Miquel, Samira Azzouz-Maache, Anne-Françoise Pétavy
The origin, differentiation and functional ultrastructure of oncospheral or egg envelopes in Echinococcus multilocularis Leuckart, 1863 were studied by transmission electron microscopy (TEM) and cytochemistry. The purpose of our study is to describe the formation of the four primary embryonic envelopes, namely vitelline capsule, outer envelope, inner envelope and oncospheral membrane, and their transformation into the oncospheral or egg envelopes surrounding the mature hexacanth. This transformation takes place in the preoncospheral phase of embryonic development...
July 2017: Parasitology Research
https://www.readbyqxmd.com/read/28592573/protocol-for-a-randomised-controlled-trial-of-the-effect-of-dapagliflozin-metformin-and-exercise-on-glycaemic-variability-body-composition-and-cardiovascular-risk-in-prediabetes-the-pre-d-trial
#15
Kristine Færch, Hanan Amadid, Lea Bruhn Nielsen, Mathias Ried-Larsen, Kristian Karstoft, Frederik Persson, Marit Eika Jørgensen
INTRODUCTION: The primary aim of this study is to compare the efficacy of three short-term glucose-lowering interventions (exercise, metformin and dapagliflozin) on glycaemic variability in overweight or obese men and women with elevated diabetes risk (ie, prediabetes, defined as haemoglobin A1c (HbA1c)39-47 mmol/mol / 5.7%-6.4%). The secondary aims are to investigate the effects of the interventions on body composition and cardiometabolic risk factors. METHODS AND ANALYSIS: The Pre-D Trial is an investigator-initiated, randomised, controlled, parallel, open-label, superiority trial...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28592311/the-effects-of-green-cardamom-on-blood-glucose-indices-lipids-inflammatory-factors-paraxonase-1-sirtuin-1-and-irisin-in-patients-with-nonalcoholic-fatty-liver-disease-and-obesity-study-protocol-for-a-randomized-controlled-trial
#16
Milad Daneshi-Maskooni, Seyed Ali Keshavarz, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Mahtab Badri-Fariman, Seyed Ali Jazayeri-Tehrani, Gity Sotoudeh
BACKGROUND: The relationship between dietary components and nonalcoholic fatty liver disease (NAFLD) needs to be further investigated. The potential health benefits of cardamom have been found in some studies. Cardamom showed beneficial effect on hepatomegaly, dyslipidemia, and fasting hyperglycemia in animals. However, some adverse effects of cardamom have been reported in animals. No previous human study had been conducted on the effects of cardamom in NAFLD. This study aims to determine the effects of green cardamom (Elettaria cardamomum) supplementation on blood glucose indices, lipids, inflammatory profiles, and liver function, especially by examining irisin, paraxonase-1 (PON1) and sirtuin-1 (Sirt1) in obese patients with NAFLD...
June 7, 2017: Trials
https://www.readbyqxmd.com/read/28587828/diphytanoyl-lipids-as-model-systems-for-studying-membrane-active-peptides
#17
Sezgin Kara, Sergii Afonin, Oleg Babii, Anton N Tkachenko, Igor V Komarov, Anne S Ulrich
The branched chains in diphytanoyl lipids provide membranes with unique properties, such as high chemical/physical stability, low water permeability, and no gel-to-fluid phase transition at ambient temperature. Synthetic diphytanoyl phospholipids are often used as model membranes for electrophysiological experiments. To evaluate whether these sturdy lipids are also suitable for solid-state NMR, we have examined their interactions with a typical amphiphilic peptide in comparison with straight-chain lipids. First, their phase properties were monitored using (31)P-NMR, and the structural behaviour of the antimicrobial peptide PGLa was studied by (19)F-NMR and circular dichroism in oriented membrane samples...
June 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28584299/dissociation-of-body-mass-index-excess-weight-loss-and-body-fat-percentage-trajectories-after-3-years-of-gastric-bypass-relationship-with-metabolic-outcomes
#18
J Gómez-Ambrosi, P Andrada, V Valentí, F Rotellar, C Silva, V Catalán, A Rodríguez, B Ramírez, R Moncada, J Escalada, J Salvador, G Frühbeck
BACKGROUND/OBJECTIVES: Body weight, body mass index (BMI) and excess weight loss (EWL) are the most frequently used measures to analyse bariatric surgery outcomes. However, these measurements do not provide accurate information on body composition (BC) with body fat (BF) importantly determining the levels of cardiometabolic risk factors. Our aim was to analyse the evolution of BC after Roux-en-Y Gastric Bypass (RYGB) and its influence on the changes of cardiometabolic risk factors in comparison to BMI and EWL...
June 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28579756/effect-of-a-food-supplement-containing-berberine-monacolin-k-hydroxytyrosol-and-coenzyme-q10-on-lipid-levels-a-randomized-double-blind-placebo-controlled-study
#19
Sergio D'Addato, Luciana Scandiani, Giuliana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli, Giuseppe Derosa
PURPOSE: To evaluate the ability of the new food supplement, Body Lipid (BL), containing red yeast rice, berberine, coenzyme Q10 and hydroxytyrosol, to lower the LDL-C in patients with mild-to-moderate hypercholesterolemia and to assess the overall safety profile of the product. METHODS: In this multicenter, randomized, double-blind, placebo and active comparator (the marketed Armolipid Plus(®) [AM]) controlled study, 158 hypercholesterolemic patients were randomized following a 4-week dietary run-in period...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28573134/high-fat-and-fat-enriched-diets-impair-the-benefits-of-moderate-physical-training-in-the-aorta-and-the-heart-in-rats
#20
Cleverson Rodrigues Fernandes, Vinicius Kannen, Karina Magalhães Mata, Fernando Tadeu Frajacomo, Alceu Afonso Jordão Junior, Bianca Gasparotto, Juliana Yumi Sakita, Jorge Elias Junior, Daphne Santoro Leonardi, Fernando Marum Mauad, Simone Gusmão Ramos, Sergio Akira Uyemura, Sergio Britto Garcia
AIM: Millions of people die each year due to cardiovascular disease (CVD). A Western lifestyle not only fuses a significant intake of fat with physical inactivity and obesity but also promotes CVD. Recent evidence suggests that dietary fat intake impairs the benefits of physical training. We investigated whether aerobic training could reverse the adverse effects of a high-fat diet (HFD) on the aorta. Then, we explored whether this type of exercise could reverse the damage to the heart that is imposed by fat-enriched diet (FED)...
2017: Frontiers in Nutrition
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