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https://www.readbyqxmd.com/read/29785046/relation-between-hypertension-and-erectile-dysfunction-a-meta-analysisof-cross-section-studies
#1
Xiao-Yan Wang, Wei Huang, Yong Zhang
Erectile dysfunction (ED) is a wide spread and troublesome problem in aging men. Many analyses of hypertensive patients suggest that the prevalence of ED in hypertensive populations is even higher. The purpose of this meta-analysis was to evaluate the relation between hypertension and ED. A literature review was performed to identify all cross-section studies about hypertension and erectile dysfunction. Sources included MEDLINE and EMBASE from 1966 to 2015. The reference lists of the retrieved studies were also investigated, and a meta-analysis were conducted...
May 22, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29781580/neuromuscular-electrical-stimulation-compared-to-volitional-exercise-in-improving-muscle-function-in-rheumatoid-arthritis-a-randomized-pilot-study
#2
Sara R Piva, Samannaaz S Khoja, Frederico G S Toledo, Mary Chester Wasko, G Kelley Fitzgerald, Bret H Goodpaster, Clair N Smith, Anthony Delitto
OBJECTIVES: To compare the feasibility and effectiveness of Neuromuscular Electrical Stimulation (NMES) with high-intensity volitional resistance training in improving muscle structure and function, and physical function in patients with rheumatoid arthritis (RA). We also described pre- and post-intervention values of myocyte characteristics. METHODS: Two-group single-blinded pilot randomized study in adults with RA. Participants were assigned to 36 sessions over 16 weeks of NMES (n=31) or volitional training (n=28)...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29777855/polymer-lipid-hybrid-nanoparticles-as-enhanced-indomethacin-delivery-systems
#3
Annalisa Dalmoro, Sabrina Bochicchio, Shamil F Nasibullin, Paolo Bertoncin, Gaetano Lamberti, Anna Angela Barba, Rouslan I Moustafine
Non-steroidal anti-inflammatory drugs (NSAIDs), i.e. indomethacin used for rheumatoid arthritis and non-rheumatoid inflammatory diseases, are known for their injurious actions on the gastrointestinal (GI) tract. Mucosal damage can be avoided by using nanoscale systems composed by a combination of liposomes and biodegradable natural polymer, i.e. chitosan, for enhancing drug activity. Aim of this study was to prepare chitosan-lipid hybrid delivery systems for indomethacin dosage through a novel continuous method based on microfluidic principles...
May 16, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29770204/diverse-pro-inflammatory-endotoxin-recognition-systems-of-mammalian-innate-immunity
#4
REVIEW
Jerrold Weiss, Jason Barker
In humans and other mammals, recognition of endotoxins-abundant surface lipopolysaccharides (LPS) of Gram-negative bacteria-provides a potent stimulus for induction of inflammation and mobilization of host defenses. The structurally unique lipid A region of LPS is the principal determinant of this pro-inflammatory activity. This region of LPS is normally buried within the bacterial outer membrane and aggregates of purified LPS, making even more remarkable its picomolar potency and the ability of discrete variations in lipid A structure to markedly alter the pro-inflammatory activity of LPS...
2018: F1000Research
https://www.readbyqxmd.com/read/29766791/immunometabolic-changes-in-hepatocytes-arising-from-obesity-and-the-practice-of-physical-exercise
#5
Paula Alves Monteiro, Wagner Prado, Thiago Ricardo Dos Santos Tenório, Luciane Magri Tomaz, David H St-Pierre, Fabio Santos Lira
Over the recent years, a particular interest was shown towards understanding the roles of excessive hepatic fat accumulation and the development of obesity-related diseases. While hepatic triacylglycerol accumulation seems to be a response to the systemic increase of insulin release, fatty acid metabolites contribute to the progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH). It is widely accepted that NAFLD is a polygenic and multifactorial disease under the influence of critical behavioral factors such as overeating and sedentary lifestyles...
May 14, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29760934/the-association-between-high-sensitivity-c-reactive-protein-and-metabolic-risk-factors-in-black-and-white-south-african-women-a-cross-sectional-study
#6
Cindy George, Juliet Evans, Lisa K Micklesfield, Tommy Olsson, Julia H Goedecke
Background: High-sensitivity C-reactive protein (hsCRP) is associated with metabolic risk, however it is unclear whether the relationship is confounded by racial/ethnic differences in socioeconomic status (SES), lifestyle factors or central adiposity. The aims of the study was, (1) to investigate whether hsCRP levels differ by race/ethnicity; (2) to examine the race/ethnic-specific associations between hsCRP, HOMA-IR and serum lipids [total cholesterol (TC), triglycerides (TG), high-density lipoproteins (HDL-C) and low-density lipoproteins (LDL-C)]; and (3) to determine whether race/ethnic-specific associations are explained by SES, lifestyle factors or waist circumference (WC)...
2018: BMC Obesity
https://www.readbyqxmd.com/read/29758395/self-reported-nocturnal-sleep-duration-and-glycosylated-hemoglobin-a-in-the-study-of-cardiovascular-risks-in-adolescents-erica
#7
Luciane Gaspar Guedes, Gabriela de Azevedo Abreu, Katia Vergetti Bloch
OBJECTIVE: At present, epidemiologic studies regarding the relationship between sleep duration and glucose metabolism in adolescents are scarce. The objective was to investigate the association between self-reported nocturnal sleep duration and glycosylated hemoglobin A in 12- to 17-year-old Brazilian adolescents. PATIENTS/METHODS: A school-based multicenter cross-sectional study was carried out in private and public schools from 273 municipalities with more than 100,000 inhabitants...
April 6, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29758349/habitual-aerobic-exercise-gene-apoa5-named-rs662799-snp-and-response-of-blood-lipid-and-lipoprotein-phenotypes-among-older-chinese-adult
#8
Xiangyun Liu, Guoyuan Huang, Zhanbin Niu, Yuqin Wei, Ru Wang
BACKGROUND: The genetic component of dyslipidemia has been studied in adults but little in older population. It is remains unknown regarding influence and interaction of APOA5 gene single nucleotide polymorphism (SNP) and habitual aerobic exercise (HAE) on changes of blood lipids and lipoprotein phenotypes in older Chinese adults. METHODS: Four-hundred-twenty-three old Chinese individuals with HAE were divided into hyperlipidemia and normal groups. We genotyped polymorphic loci using matrix assisted laser desorption ionization time of flight mass spectrometry detection technology (MALDI-TOF)...
May 11, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29756962/impact-of-apoe2allele-on-lipid-profile-change-after-a-weight-loss-program
#9
Blanca Romero-Moraleda, Rocío Cupeiro Coto, Domingo González-Lamuño, Teresa Amigo, Barbara Szendrei, Miguel Ángel Rojo-Tirado, Francisco Javier Calderón, Ana Belén Peinado
BACKGROUND: apolipoprotein E (ApoE) polymorphism is a genetic determinant of lipid and lipoprotein levels and the risk for coronary heart disease. OBJECTIVE: to evaluate the impact of ApoE2allele in lipid plasma levels and the influence of a healthy hypocaloric diet plus a controlled physical activity on the lipid profile, we performed a study in a cohort of overweight and obese healthy subjects (Body Mass Index (BMI) between 25 and 34.9 kg·m-2). METHODS: one hundred eighty participants (96 women), aged 18-50 years participated in a 22 weeks weight loss intervention based on same dietary treatment and different controlled exercise programs...
March 1, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29756961/prevalence-of-metabolic-syndrome-and-its-determinants-in-older-mexican-non-diabetic-adults
#10
Heliodoro Alemán Mateo, Miriam T López Teros, Rene Urquidez-Romero, Luis Huesca
INTRODUCTION: the prevalence of metabolic syndrome (MetS) is high in older people, and several factors have been explored as main determinants. However, few data exist for older people from low- and middle-income countries. Therefore, our objective was to estimate the prevalence of MetS. Secondly, to explore which of the cardio-metabolic, body composition, inflammatory and demographic risk factors were associated with the prevalence of MetS in a population of older Mexican adults. METHODS: data for this analysis were collected in subjects over 60 years of age from northwest Mexico...
February 27, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29756514/ilex-paraguariensis-extends-lifespan-and-increases-an-ability-to-resist-environmental-stresses-in-drosophila
#11
Prakshit Niraula, Saurav Ghimire, Hanna Lee, Man Su Kim
Aging is a complex process resulting in: i) a decline in body functions and capacity to withstand environmental stress and ii) an increased susceptibility to diseases including, but not limited to, cardiovascular disorders, diabetes, cancer and dementia. Among a number of herbal products used to alleviate symptoms associated with aging is Ilex paraguariensis (IP). This product has been reported to have anticancer, anti-inflammatory and antioxidant activities. However, its effect on an organisms' longevity has not been thoroughly studied to date...
May 14, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29755224/no-differences-in-energy-cost-of-a-predetermined-exercise-among-young-overweight-obese-and-undernourished-individuals
#12
D V Muralidhara, Mohd Nasir Mat Nor, Ahmad L Zubaidi
Background: Physical activity is an integral part of one's daily life. Obese (Ob) and undernourished (UN) persons are known to underperform physically as compared to normal weight (N) individuals. In this study, we have measured the energy spent to perform a prefixed exercise on treadmill walking and basal heart rate and blood pressure. Body mass index (BMI) and body fat of participating individuals were assessed. Fasting blood sugar and lipid profile were also evaluated. Materials and Methods: Eighty-three young individuals (male: 41; female: 42) of medical faculty, Universiti Sultan Zainal Abidin, who volunteered for the study, were recruited...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29752857/prevalence-and-risk-factors-of-metabolic-syndrome-in-hiv-infected-adults-at-three-urban-clinics-in-a-post-conflict-setting-eastern-democratic-republic-of-congo
#13
Patrick D M C Katoto, Friedrich Thienemann, André N H Bulabula, Tonya M Esterhuizen, Aimé B Murhula, Pierre P M Lunjwire, Dieudonné M Bihehe, Jean B Nachega
OBJECTIVE: To determine the prevalence of and risk factors for metabolic syndrome (MS) in HIV-infected adults at three urban clinics in Bukavu, Democratic Republic of the Congo. DESIGN: Cross-sectional study. METHODS: From July to September 2016, baseline socio-demographics, risk factors, and clinical characteristics were collected using a structured questionnaire or extracted from medical records. Fasting blood sugar and lipids were measured...
May 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29750416/serum-25-hydroxyvitamin-d-plasma-lipids-and-associated-gene-variants-in-prepubertal-children
#14
Sonja Soininen, Aino-Maija Eloranta, Anna Viitasalo, Geneviève Dion, Arja Erkkilä, Virpi Sidoroff, Virpi Lindi, Anitta Mahonen, Timo A Lakka
Context: The associations of serum 25-hydroxyvitamin D (25(OH)D) with plasma lipids remain controversial in children. Objective: To examine the associations and interactions of 25(OH)D and related gene variants with lipids in children. Design: Cross-sectional. Setting: City of Kuopio, Finland. Participants: Population sample of 419 prepubertal Caucasian children aged 6-8 years. Main Outcome Measures: 25(OH)D, total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), and triglycerides...
May 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29749982/prevalence-of-multiple-coronary-artery-disease-risk-factors-in-kerman-a-population-based-study-in-southeast-iran
#15
Hamid Najafipour, Mahdi Afshari, Farzaneh Rostamzadeh
Background: The risk of disease with 1 risk factor is increased by the presence of additional risk factors. The goal of this study was to assess the prevalence of multiple coronary artery disease (CAD) risk factors among adults in Kerman, Iran, to identify the population groups most at risk. Methods: The present study included 5900 adults aged between 15 and 75 years in 2011 in Kerman, Iran. They were selected by 1-stage cluster sampling. Blood pressure, fasting blood glucose, lipids, and 6 CAD risk factors were assessed in the study population...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29748909/the-effect-of-storage-temperature-on-the-biological-activity-of-extracellular-vesicles-for-the-complement-system
#16
Sang June Park, Hyungtaek Jeon, Seung-Min Yoo, Myung-Shin Lee
Extracellular vesicles (EVs) are mediators of intercellular communication by transporting cargo containing proteins, lipids, mRNA, and miRNA. There is increasing evidence that EVs have various roles in regulating migration, invasion, stemness, survival, and immune functions. Previously, we have found that EVs from Kaposi's sarcoma-associated herpesvirus (KSHV)-infected human endothelial cells have the potential to activate the complement system. Although many studies have shown that the physical properties of EVs can be changed by their storage condition, there have been few studies for the stability of biological activity of EVs in various storage conditions...
May 10, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29742682/lipid-accumulation-product-and-visceral-adiposity-index-are-associated-with-dietary-patterns-in-adult-americans
#17
Mohsen Mazidi, Hong-Kai Gao, Andre Pascal Kengne
In the present study, we aimed to examine the association between lipid accumulation product (LAP) and visceral adiposity index (VAI) with dietary pattern (DP) in the US adults. Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on dietary intake from 2005 to 2010 were included. DPs were derived by principal component analysis. We applied analysis of covariance and multivariable-adjusted linear regressions accounting for the masked variance and utilizing the proposed weighting methodology...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29738378/promotion-of-home-based-exercise-training-as-secondary-prevention-of-coronary-heart-disease-a-pilot-web-based-intervention
#18
Anna Torri, Claudia Panzarino, Anna Scaglione, Maddalena Modica, Bruno Bordoni, Raffaella Redaelli, Renata De Maria, Maurizio Ferratini
BACKGROUND: Although cardiac rehabilitation (CR) is cost-effective in improving the health of patients with coronary heart disease (CHD), less than half of eligible CHD patients attend a CR program. Innovative web-based technologies might improve CR delivery and utilization. We assessed the feasibility and impact on functional capacity and secondary prevention targets of a long-term web-monitored exercise-based CR maintenance program. METHODS: Low- to moderate-risk CHD patients were recruited at discharge from inpatient CR after a coronary event or revascularization...
April 30, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29734771/a-method-for-efficient-loading-of-ciprofloxacin-hydrochloride-in-cationic-solid-lipid-nanoparticles-formulation-and-microbiological-evaluation
#19
Rosario Pignatello, Antonio Leonardi, Virginia Fuochi, Giulio Petronio Petronio, Antonio S Greco, Pio Maria Furneri
The aim of the study was the production of solid lipid nanoparticles (SLN) loaded with ciprofloxacin (CIP) through two different production techniques, quasi-emulsion solvent diffusion (QESD) and solvent injection (SI). In order to efficaciously entrap the commercial salt form (hydrochloride) of the antibiotic in these lipid systems, a conversion of CIP hydrochloride to the free base was realized in situ, through the addition of triethylamine. To ensure physical stability to the carriers over time and ameliorate the interaction with bacterial cell membranes, positively charged SLN were produced by addition of the cationic lipid didecyldimethylammonium bromide (DDAB)...
May 6, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29731703/metabolic-syndrome-and-neuroprotection
#20
REVIEW
Melisa Etchegoyen, Mariana H Nobile, Francisco Baez, Barbara Posesorski, Julian González, Néstor Lago, José Milei, Matilde Otero-Losada
Introduction: Over the years the prevalence of metabolic syndrome (MetS) has drastically increased in developing countries as a major byproduct of industrialization. Many factors, such as the consumption of high-calorie diets and a sedentary lifestyle, bolster the spread of this disorder. Undoubtedly, the massive and still increasing incidence of MetS places this epidemic as an important public health issue. Hereon we revisit another outlook of MetS beyond its classical association with cardiovascular disease (CVD) and Diabetes Mellitus Type 2 (DM2), for MetS also poses a risk factor for the nervous tissue and threatens neuronal function...
2018: Frontiers in Neuroscience
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