Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Mengsha Yao, Susan E Luczak, I Gary Rosen
LQG control in Hilbert space, a novel approach for random abstract parabolic systems, and new transdermal alcohol biosensor technology are combined to yield tracking controllers that can be used to automate inpatient management of alcohol withdrawal syndrome and human subject intravenous alcohol infusion studies, and to blindly deconvolve blood or breath alcohol concentration from biosensor measured transdermal alcohol level. The approach taken is based on a full-body alcohol population model in the form of a random, nonlinear, hybrid system of ordinary and partial differential equations and its abstract formulation in a Gelfand triple of Bochner spaces...
January 2023: Automatica: the Journal of IFAC, the International Federation of Automatic Control
#2
JOURNAL ARTICLE
Laisa Bonafim Negri, Yara Mannaa, Sandeep Korupolu, William A Farinelli, R Rox Anderson, Jeffrey A Gelfand
Cutaneous bacterial wound infections typically involve gram-positive cocci such as Staphylococcus aureus (SA) and usually become biofilm infections. Bacteria in biofilms may be 100-1000-fold more resistant to an antibiotic than the clinical laboratory minimal inhibitory concentration (MIC) for that antibiotic, contributing to antimicrobial resistance (AMR). AMR is a growing global threat to humanity. One pathogen-antibiotic resistant combination, methicillin-resistant SA (MRSA) caused more deaths globally than any other such combination in a recent worldwide statistical review...
May 4, 2023: Journal of Photochemistry and Photobiology. B, Biology
#3
JOURNAL ARTICLE
Alysa J Baumann, Kerry O Cleveland, Michael S Gelfand, Nicholson B Perkins Iii, Angela D Covington, Athena L V Hobbs
Intravenous (IV) drugs are administered through infusion pumps and IV administration sets for patients who are seen in healthcare settings. There are multiple areas of the medication administration process that can influence the amount of a drug a patient receives. For example, IV administration sets that deliver a drug from an infusion bag to a patient vary in terms of length and bore. In addition, fluid manufacturers report that the total acceptable volume range for a 250 mL bag of normal saline can be anywhere from 265 to 285 mL...
April 13, 2023: Pharmacy (Basel, Switzerland)
#4
JOURNAL ARTICLE
McKayla Kelly, Justin Turcotte, M Brook Fowler, Michaline West, Cyrus Lashgari, Jeffrey Gelfand
Background: The purpose of this study is to evaluate the impact of intravenous tranexamic acid on clinical and hematologic outcomes after total shoulder arthroplasty. Methods: Retrospective review was conducted for 282 consecutive patients undergoing either anatomic shoulder arthroplasty or reverse total shoulder arthroplasty. Univariate analysis and multivariate linear regression were used to compare outcomes for patients receiving intravenous tranexamic acid with those who did not...
October 2022: Shoulder & Elbow
#5
JOURNAL ARTICLE
Jordan K Abbott, Sanny K Chan, Morgan MacBeth, James L Crooks, Cathy Hancock, Vijaya Knight, Erwin W Gelfand
Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, subjects with humoral immunodeficiency receiving replacement doses of IVIG were studied over 3 infusion cycles. Questionnaire data from 6 time points spread over 3 IVIG infusions cycles (infusion day and 7 days after each infusion) were collected in conjunction with monitoring the blood for number of regulatory T-cells (Treg) and levels of 40 secreted analytes: primarily cytokines, chemokines, and growth factors...
2022: PloS One
#6
JOURNAL ARTICLE
Sara Pavitt, Amy A Gelfand, Natalia Zorrilla, Isabel Allen, Nina Riggins
BACKGROUND: Chronic headache disorders can cause substantial disability and be treatment refractory. Often, these patients are excluded from clinical trials with leaving little evidence to guide treatment. In adults, divalproex sodium is an effective preventive migraine treatment. METHODS: All pediatric patients admitted for first-time sodium valproate infusions to treat refractory, chronic migraine (CM), new daily persistent headache, or persistent headache attributed to head trauma from January 2017 to October 2020 were identified for review...
March 2022: Pediatric Neurology
#7
JOURNAL ARTICLE
Katsuyuki Takeda, Soo-Hyun Kim, Anthony Joetham, Irina Petrache, Erwin W Gelfand
BACKGROUND: Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema. In well-selected AATD patients, therapy with plasma-derived AAT (pAAT), "augmentation therapy", provides modest clinical improvement but is perceived as cumbersome with weekly intravenous infusions. Using mouse models of emphysema, we compared the effects of a recombinant AAT-IgG1 Fc-fusion protein (AAT-Fc), which is expected to have a longer half-life following infusion, to those of pAAT...
July 16, 2021: Respiratory Research
#8
JOURNAL ARTICLE
Esha Kothekar, Mona-Elisabeth Revheim, Austin J Borja, Emily C Hancin, Donald K Detchou, Thomas J Werner, Daniel B Shin, Joel M Gelfand, Abass Alavi
Psoriatic skin lesions are metabolically active, which makes them candidates for imaging with 18-F fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). The aim of our study was to correlate FDG-PET findings with Psoriasis Area and Severity Index (PASI) scores, the most widely-used grading system for psoriasis. Thirty-three subjects and a total of 84 FDG-PET/CT scans from a prospective clinical trial [NCT01553058] with >2 months moderate-to-severe psoriasis were included. Subjects underwent whole-body FDG-PET/CT imaging 60 min after intravenous FDG administration, prior to the start of treatment...
2020: American Journal of Nuclear Medicine and Molecular Imaging
#9
JOURNAL ARTICLE
Jocelyn R Farmer, Zsofia Foldvari, Boglarka Ujhazi, Suk See De Ravin, Karin Chen, Jack J H Bleesing, Catharina Schuetz, Waleed Al-Herz, Roshini S Abraham, Avni Y Joshi, Beatriz T Costa-Carvalho, David Buchbinder, Claire Booth, Andreas Reiff, Polly J Ferguson, Asghar Aghamohammadi, Hassan Abolhassani, Jennifer M Puck, Mehdi Adeli, Caterina Cancrini, Paolo Palma, Alice Bertaina, Franco Locatelli, Gigliola Di Matteo, Raif S Geha, Maria G Kanariou, Lilia Lycopoulou, Marianna Tzanoudaki, John W Sleasman, Suhag Parikh, Gloria Pinero, Bernard M Fischer, Ghassan Dbaibo, Ekrem Unal, Turkan Patiroglu, Musa Karakukcu, Khulood Khalifa Al-Saad, Meredith A Dilley, Sung-Yun Pai, Cullen M Dutmer, Erwin W Gelfand, Christoph B Geier, Martha M Eibl, Hermann M Wolf, Lauren A Henderson, Melissa M Hazen, Carmem Bonfim, Beata Wolska-Kuśnierz, Manish J Butte, Joseph D Hernandez, Sarah K Nicholas, Polina Stepensky, Shanmuganathan Chandrakasan, Maurizio Miano, Emma Westermann-Clark, Vera Goda, Gergely Kriván, Steven M Holland, Olajumoke Fadugba, Sarah E Henrickson, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Ayca Kiykim, Robbert Bredius, Birgit Hoeger, Kaan Boztug, Olga Pashchenko, Benedicte Neven, Despina Moshous, Jean-Pierre de Villartay, Ahmed Aziz Bousfiha, Harry R Hill, Luigi D Notarangelo, Jolan E Walter
BACKGROUND: Although autoimmunity and hyperinflammation secondary to recombination activating gene (RAG) deficiency have been associated with delayed diagnosis and even death, our current understanding is limited primarily to small case series. OBJECTIVE: Understand the frequency, severity, and treatment responsiveness of autoimmunity and hyperinflammation in RAG deficiency. METHODS: In reviewing the literature and our own database, we identified 85 patients with RAG deficiency, reported between 2001 and 2016, and compiled the largest case series to date of 63 patients with prominent autoimmune and/or hyperinflammatory pathology...
July 2019: Journal of Allergy and Clinical Immunology in Practice
#10
JOURNAL ARTICLE
Parmanand Singh, Silvia González-Ramos, Marina Mojena, César Eduardo Rosales-Mendoza, Hamed Emami, Jeffrey Swanson, Alex Morss, Zahi A Fayad, James H F Rudd, Jeffrey Gelfand, Marta Paz-García, Paloma Martín-Sanz, Lisardo Boscá, Ahmed Tawakol
UNLABELLED: (18)F-FDG accumulates in glycolytically active tissues and is known to concentrate in tissues that are rich in activated macrophages. In this study, we tested the hypotheses that human granulocyte-macrophage colony-stimulating factor (GM-CSF), a clinically used cytokine, increases macrophage glycolysis and deoxyglucose uptake in vitro and acutely enhances (18)F-FDG uptake within inflamed tissues such as atherosclerotic plaques in vivo. METHODS: In vitro experiments were conducted on human macrophages whereby inflammatory activation and uptake of radiolabeled 2-deoxyglucose was assessed before and after GM-CSF exposure...
September 2016: Journal of Nuclear Medicine
#11
JOURNAL ARTICLE
Reo Yasuma, Valeria Cicatiello, Takeshi Mizutani, Laura Tudisco, Younghee Kim, Valeria Tarallo, Sasha Bogdanovich, Yoshio Hirano, Nagaraj Kerur, Shengjian Li, Tetsuhiro Yasuma, Benjamin J Fowler, Charles B Wright, Ivana Apicella, Adelaide Greco, Arturo Brunetti, Balamurali K Ambati, Sevim Barbasso Helmers, Ingrid E Lundberg, Ondrej Viklicky, Jeanette Hw Leusen, J Sjef Verbeek, Bradley D Gelfand, Ana Bastos-Carvalho, Sandro De Falco, Jayakrishna Ambati
Human intravenous immune globulin (IVIg), a purified IgG fraction composed of ~ 60% IgG1 and obtained from the pooled plasma of thousands of donors, is clinically used for a wide range of diseases. The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG (IgG) Fc regions. Recently, we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI, a high-affinity receptor for IgG1...
2016: Signal Transduction and Targeted Therapy
#12
JOURNAL ARTICLE
Melanie E Gelfand, Rodney A Gabriel, Robert Gimlich, Sascha S Beutler, Richard D Urman
Assessing the depth of anesthesia and reducing intraoperative awareness has become a focus of much technology development and research in the field of anesthesia. Bispectral index (BIS) is the most widely utilized technology that uses electroencephalogram to provide a measurement of anesthetic depth. There are no definitive guidelines on when BIS should be used. Our aim was to assess actual patterns of intraoperative use of BIS by anesthesia professionals. We retrospectively collected intraoperative data on 55,210 surgical cases at a tertiary care hospital...
April 2017: Journal of Clinical Monitoring and Computing
#13
JOURNAL ARTICLE
Carolyn Bevan, Jeffrey M Gelfand
While not all multiple sclerosis (MS) relapses require treatment, relapses that are bothersome or that impair function should prompt consideration of timely treatment to restore function and minimize disability. Patients with suspected MS relapses should be evaluated to confirm the diagnosis, exclude other causes of neurological dysfunction, and identify potential triggers for relapse or pseudo-relapse, such as urinary tract infections, fever, or metabolic derangements. The diagnosis of an MS relapse is clinical, but MRI may be useful for confirmation and to evaluate for multifocal disease activity...
April 2015: Current Treatment Options in Neurology
#14
JOURNAL ARTICLE
Frederic Fahey, Katherine Zukotynski, David Zurakowski, Robert Markelewicz, Anthony Falone, Marie Vitello, Xinhua Cao, Frederick Grant, Laura Drubach, A Hans Vija, Manojeet Bhattacharya, Xinhong Ding, Zvi Bar-Sever, Michael Gelfand, S Ted Treves
PURPOSE: To determine if the minimum administered radiopharmaceutical activity for hepatobiliary scintigraphy can be reduced while preserving diagnostic image quality using enhanced planar processing (EPP). METHODS: A total of 40 infants between 10 and 270 days old (body mass 2.2 - 6.5 kg) had hepatobiliary scintigraphy during the period 2004 - 2010 following the intravenous administration of either (99m)Tc-mebrofenin (18 patients) or (99m)Tc-disofenin (22 patients)...
December 2014: European Journal of Nuclear Medicine and Molecular Imaging
#15
JOURNAL ARTICLE
Sarosh R Irani, Jeffrey M Gelfand, Brianne M Bettcher, Neel S Singhal, Michael D Geschwind
IMPORTANCE: This observational study describes the efficacy and safety of rituximab in 5 patients with voltage-gated potassium channel (VGKC)-complex/leucine-rich, glioma-inactivated 1 (LGI1) antibody-associated encephalopathy. Rituximab is a monoclonal antibody that targets CD20 and is used to treat other neurologic and nonneurologic diseases. OBSERVATIONS: This case series reports sequential seizure frequencies, modified Rankin Scale scores, and VGKC-complex antibody titers in 5 adult patients (median age, 65 years; range, 48-73 years) treated with rituximab...
July 1, 2014: JAMA Neurology
#16
REVIEW
Maaz S Mohiuddin, Jordan K Abbott, Nicholas Hubbard, Troy R Torgerson, Hans D Ochs, Erwin W Gelfand
No abstract text is available yet for this article.
June 2013: Journal of Allergy and Clinical Immunology
#17
REVIEW
Erwin W Gelfand, Hans D Ochs, William T Shearer
This Current perspectives article will review and highlight the importance of accurate diagnosis of patients who have failed to produce specific antibodies to naturally encountered foreign proteins or polysaccharides or after vaccination and the appropriate institution of immunoglobulin replacement therapy. The field of primary immunodeficiency disease (PIDD) has expanded remarkably since the early descriptions 6 decades ago. With greater recognition and advanced cellular and molecular diagnostic technology, new entities and single-gene defects in patients with PIDD are rapidly being defined...
April 2013: Journal of Allergy and Clinical Immunology
#18
REVIEW
Erwin W Gelfand
New England Journal of Medicine, Volume 367, Issue 21, Page 2015-2025, November 2012.
November 22, 2012: New England Journal of Medicine
#19
REVIEW
Jamie D Murphy, Harold J Gelfand, Mark C Bicket, Jean-Pierre P Ouanes, Kanupriya K Kumar, Gillian R Isaac, Christopher L Wu
OBJECTIVES: Pruritus may be a significant problem for patients in the postoperative period. There are many options for the treatment of pruritus including intravenous (IV) naloxone. However, it is not clear whether the use of IV naloxone may also affect analgesia or other opioid-related side effects. The authors have performed a systematic review to further examine this issue. METHODS: Systematic literature searches of the National Library of Medicine's PubMed and EMBASE databases were conducted using terms related to postoperative use of IV naloxone...
July 2011: Journal of Opioid Management
#20
JOURNAL ARTICLE
Amar Dhand, Kazuma Nakagawa, Seema Nagpal, Jeffrey M Gelfand, Anthony S Kim, Wade S Smith, Tarik Tihan
BACKGROUND: Ventricular free wall rupture is a fatal complication of myocardial infarction (MI). Although described in MI patients who receive thrombolytic therapy, this complication is not well known in ischemic stroke patients who receive intravenous (IV) t-PA. METHODS: Case report. RESULTS: We present a 93-year-old woman with an acute onset of a right middle cerebral artery syndrome in the setting of subacute MI. IV t-PA was administered and she subsequently developed asystolic arrest and died...
October 2010: Neurocritical Care
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
