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https://www.readbyqxmd.com/read/28819800/nanotechnology-from-in-vivo-imaging-system-to-controlled-drug-delivery
#1
REVIEW
Maria Mir, Saba Ishtiaq, Samreen Rabia, Maryam Khatoon, Ahmad Zeb, Gul Majid Khan, Asim Ur Rehman, Fakhar Ud Din
Science and technology have always been the vitals of human's struggle, utilized exclusively for the development of novel tools and products, ranging from micro- to nanosize. Nanotechnology has gained significant attention due to its extensive applications in biomedicine, particularly related to bio imaging and drug delivery. Various nanodevices and nanomaterials have been developed for the diagnosis and treatment of different diseases. Herein, we have described two primary aspects of the nanomedicine, i.e...
August 17, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28815721/rgd-peptide-based-target-drug-delivery-of-doxorubicin-nanomedicine
#2
Yuan Sun, Chen Kang, Fei Liu, You Zhou, Lei Luo, Hongzhi Qiao
Preclinical Research Doxorubicin (DOX) is commonly used for the treatment of breast cancer and lymphoma. However, its clinical use has been severely limited due to cardiotoxicity, requiring the development of safer and more efficient pharmaceutical formulations of DOX. Advances in nanotechnology have provided new ways to administer chemotherapeutic drugs like DOX are conveyed into the body and to tumor sites. These Nanotechnology approaches have aided in the selective accumulation of DOX into tumor sites via the enhanced permeability and retention...
August 16, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28795530/construction-of-silica-based-micro-nanoplatforms-for-ultrasound-theranostic-biomedicine
#3
REVIEW
Yang Zhou, Xiaoxia Han, Xiangxiang Jing, Yu Chen
Ultrasound (US)-based biomedicine has been extensively explored for its applications in both diagnostic imaging and disease therapy. The fast development of theranostic nanomedicine significantly promotes the development of US-based biomedicine. This progress report summarizes and discusses the recent developments of rational design and fabrication of silica-based micro/nanoparticles for versatile US-based biomedical applications. The synthetic strategies and surface-engineering approaches of silica-based micro/nanoparticles are initially discussed, followed by detailed introduction on their US-based theranostic applications...
August 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28791576/tolerogenic-nanoparticles-to-treat-islet-autoimmunity
#4
REVIEW
Tobias Neef, Stephen D Miller
PURPOSE OF REVIEW: The current standard therapy for type 1 diabetes (T1D) is insulin replacement. Autoimmune diseases are typically treated with broad immunosuppression, but this has multiple disadvantages. Induction of antigen-specific tolerance is preferable. The application of nanomedicine to the problem of T1D can take different forms, but one promising way is the development of tolerogenic nanoparticles, the aim of which is to mitigate the islet-destroying autoimmunity. We review the topic and highlight recent strategies to produce tolerogenic nanoparticles for the purpose of treating T1D...
August 8, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28782570/nanomedicine-and-advanced-technologies-for-burns-preventing-infection-and-facilitating-wound-healing
#5
Mirza Ali Mofazzal Jahromi, Parham Sahandi Zangabad, Seyed Masoud Moosavi Basri, Keyvan Sahandi Zangabad, Ameneh Ghamarypour, Amir R Aref, Mahdi Karimi, Michael R Hamblin
According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections...
August 3, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28780932/cancer-nanomedicine-lessons-for-immuno-oncology
#6
REVIEW
Shiladitya Sengupta
Cancer nanotechnology and cancer immunotherapy are two parallel themes that have emerged over the last few decades in the search for a cure for cancer. Exciting applications can emerge at the intersection of these two fields. However, it is important to learn from the past successes and failures of cancer nanomedicines for its future applications in cancer immunotherapy. This review discusses the two key parameters that defined clinical success in the case of cancer nanomedicines: (i) physicochemical design principles, and (ii) clinical trial design, which are frequently overlooked in most analyses of the state of the field...
August 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28761415/dual-and-multi-drug-delivery-nanoparticles-towards-neuronal-survival-and-synaptic-repair
#7
REVIEW
Angelina Angelova, Borislav Angelov
Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related kinase receptor (TrkB) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB (cAMP response element-binding protein) has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28758581/implications-of-pegylation-of-carbon-nanotubes-for-central-nervous-system-bioavailability
#8
Gisele Eva Bruch, Marcos F Cordeiro, Livia S Gomides, Carolina Peixoto, Arthur P Cordeiro, Lidiane Dal Bosco, Adelina P Santos, Daniela M Barros
In this mini-review we have compiled the most recent and comparable information to shed a light on the action of PEGylation in the biodistribution of Carbon Nanotubes (CNT) in the Central Nervous System (CNS). It is well known that due to the complexity of the CNS and the severity of the outcome of changes in this system, this is one of the areas where there are more investments in research to develop new technologies and approaches for more effective and less invasive treatments. The CNS is highly protected against toxic and invasive microorganisms thanks to the blood brain barrier (BBB), but this protection also prevents the passage of potentially beneficial molecules for the treatment of neurological disorders, Nanotechnology attempts to develop nanocompounds that are biocompatible and non-immunogenic, and that are able to cross the BBB in therapeutic amounts without causing damage and to diffuse through nerve tissue...
July 31, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28756272/novel-nanosystems-for-the-treatment-of-ocular-inflammation-current-paradigms-and-future-research-directions
#9
REVIEW
Lida Lalu, Vishakha Tambe, Deepak Pradhan, Kritika Nayak, Suchandra Bagchi, Rahul Maheshwari, Kiran Kalia, Rakesh Kumar Tekade
Ocular discomforts involve anterior/posterior-segment diseases, symptomatic distress and associated inflammations and severe retinal disorders. Conventionally, the formulations such as eye drops, eye solutions, eye ointments and lotions, etc. were used as modalities to attain relief from such ocular discomforts. However, eye allows limited access to these traditional formulations due to its unique anatomical structure and dynamic ocular environment and therefore calls for improvement in disease intervention...
July 26, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28754609/the-drug-delivery-field-at-the-inflection-point-time-to-fight-its-way-out-of-the-egg
#10
Kinam Park
The world is becoming a better place, in part, by breakthrough findings by scientists. In the drug delivery field, many breakthrough formulations have been achieved helping patients deal with various diseases effectively. The recent progress, however, has been slowing down, and many important drug delivery problems have not been resolved. They can be overcome by understanding the causes and finding the remedies. For the last three decades, the field has been overwhelmed by nanotechnology, nanomedicine, and many nano-sized drug delivery systems...
July 25, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28745122/cell-membrane-derived-nanoparticles-emerging-clinical-opportunities-for-targeted-drug-delivery
#11
Svetlana T Yurkin, Zhenjia Wang
Biofunctionalization of nanoparticles (NPs) is an essential component in targeted drug delivery. However, current nanotechnology remains inadequate to imitate complex intercellular interactions existing in physiological conditions in human bodies. Emerging concepts have been explored to utilize human cells to generate cell membrane-formed NPs because cells retain inherent abilities to interact with human tissues compared with synthetic nanomaterials. Neutrophils, red blood cells (RBCs), platelets and monocytes have been employed to form therapeutic NPs to treat vascular disease and cancer, and these novel drug delivery platforms show the translation potential to improve patient quality of life...
August 2017: Nanomedicine
https://www.readbyqxmd.com/read/28733245/engineered-nanoparticles-for-the-detection-treatment-and-prevention-of-atherosclerosis-how-close-are-we
#12
REVIEW
Luong T H Nguyen, Aristo Muktabar, Jinkai Tang, Vinayak P Dravid, C Shad Thaxton, Subbu Venkatraman, Kee Woei Ng
Atherosclerosis is one of the leading causes of morbidity and mortality worldwide. Nanotechnology has provided the possibility of designing nanoparticles that can translocate through tissues and home in to atherosclerotic plaques to achieve desired diagnostic, therapeutic, theranostic or 'theralivery' outcomes. Although nanomedicine approaches have demonstrated exciting possibilities, clinical reality is still distant and challenges are aplenty, such as specificity of targeting and nanotoxicity. Nevertheless, developments in formulations, delivery strategies and experimental models over the coming years will generate new knowledge to define the true potential of this field...
July 18, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28730451/using-planar-phi29-prna-three-way-junction-to-control-size-and-shape-of-rna-nanoparticles-for-biodistribution-profiling-in-mice
#13
Farzin Haque, Congcong Xu, Daniel L Jasinski, Hui Li, Peixuan Guo
RNA is rapidly emerging as a versatile building block for nanoparticle assembly due to its simplicity in base pairing, while exhibiting diversity in function such as enzymatic activity similar to some proteins. Recent advances in RNA nanotechnology have generated significant interests in applying RNA nanoparticles for various applications in nanotechnology and nanomedicine. In particular, assessing the effect of size and shape on cell entry and intracellular trafficking as well as in vivo biodistribution of nanoparticles is challenging due to the lack of nanoparticles rich in structure while varying in size and shape...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730435/supported-fluid-lipid-bilayer-as-a-scaffold-to-direct-assembly-of-rna-nanostructures
#14
Aleksandra P Dabkowska, Agnes Michanek, Luc Jaeger, Arkadiusz Chworos, Tommy Nylander, Emma Sparr
RNA architectonics offers the possibility to design and assemble RNA into specific shapes, such as nanoscale 3D solids or nanogrids. Combining the minute size of these programmable shapes with precise positioning on a surface further enhances their potential as building blocks in nanotechnology and nanomedicine. Here we describe a bottom-up approach to direct the arrangement of nucleic acid nanostructures by using a supported fluid lipid bilayer as a surface scaffold. The strong attractive electrostatic interactions between RNA polyanions and cationic lipids promote RNA adsorption and self-assembly...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28705729/nanomedicine-and-epigenome-possible-health-risks
#15
Bozena Smolkova, Maria Dusinska, Alena Gabelova
Nanomedicine is an emerging field that combines knowledge of nanotechnology and material science with pharmaceutical and biomedical sciences, aiming to develop nanodrugs with increased efficacy and safety. Compared to conventional therapeutics, nanodrugs manifest higher stability and circulation time, reduced toxicity and improved targeted delivery. Despite the obvious benefit, the accumulation of imaging agents and nanocarriers in the body following their therapeutic or diagnostic application generates concerns about their safety for human health...
July 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28675413/nano-p%C3%A3-gott-och-ont-m%C3%A3-jligheter-och-risker-med-nanoteknologi
#16
Bengt Fadeel
Engineered nanomaterials are produced for a wide range of applications, not least in medicine. Indeed, the field of nanomedicine is rapidly attaining maturity, with novel nanoscale constructs for diagnosis or therapy, or both (so-called theranostics). However, close attention should be paid to the potential environmental and human health impact of the emerging nanotechnologies. More information on human and environmental exposure is needed, along with a more detailed understanding of the hazard potential of different classes of nanomaterials...
July 4, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28669714/parameters-affecting-the-enhanced-permeability-and-retention-effect-the-need-for-patient-selection
#17
Az Alddien Natfji, Divyashree Ravishankar, Helen M I Osborn, Francesca Greco
The enhanced permeability and retention (EPR) effect constitutes the rationale by which nanotechnologies selectively target drugs to tumors. Despite promising pre-clinical and clinical results, these technologies have, in our view, underachieved compared to their potential, possibly due to a suboptimal exploitation of the EPR effect. Here, we have systematically analyzed clinical data to identify key parameters affecting the extent of the EPR effect. An analysis of 17 clinical studies showed that the magnitude of the EPR effect was varied and was influenced by tumor type and size...
June 29, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28669337/synthetic-lethality-from-research-to-precision-cancer-nanomedicine
#18
Anuradha Gupta, Anas Ahmad, Aqib Iqbal Dar, Rehan Khan
Cancer is an evolutionary disease with multiple genetic alterations, accumulated due to chromosomal instability and/or aneuploidy and it sometimes acquires drug-resistant phenotype also. Whole genome sequencing and mutational analysis helped in understanding the differences among persons for predisposition of a disease and its treatment non-responsiveness. Thus, molecular targeted therapies came into existence. Among them, the concept of synthetic lethality have enthralled great attention as it is a pragmatic approach towards exploiting cancer cell specific mutations to specifically kill cancer cells without affecting normal cells and thus enhancing anti-cancer drug therapeutic index...
June 30, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28643452/emerging-nanotechnology-and-advanced-materials-for-cancer-radiation-therapy
#19
REVIEW
Guosheng Song, Liang Cheng, Yu Chao, Kai Yang, Zhuang Liu
Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages...
June 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28641516/updated-regulatory-considerations-for-nanomedicines
#20
Sankarankutty Subin, Venugopal Vijayan, Jaya Raja Kumar
BACKGROUND: Nanomedicine is a branch which deals with medicinal products, devices, non-biological complex drugs and antibody-nanoparticle conjugates and general health products that are manufactured using nanotechnology. OBJECTIVE: Nanomedicine provide the same efficacies as traditional medicines owing to their improved solubility and bioavailability with reduced dosages. However, there are currently safety concerns due to the difficulties related to nanomaterial characterization; this might be the reason for unawareness of such medicines among the patients...
June 14, 2017: Pharmaceutical Nanotechnology
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