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https://www.readbyqxmd.com/read/27912846/new-insights-and-evolving-role-of-pegylated-liposomal-doxorubicin-in-cancer-therapy
#1
REVIEW
Alberto A Gabizon, Yogita Patil, Ninh M La-Beck
We herein review various pharmacological and clinical aspects of pegylated liposomal doxorubicin (PLD), the first nanomedicine to be approved for cancer therapy, and discuss the gap between its potent antitumor activity in preclinical studies and its comparatively modest achievements in clinical studies and limited use in clinical practice. PLD is a complex formulation of doxorubicin based on pharmaceutical nanotechnology with unique pharmacokinetic and pharmacodynamic properties. Its long circulation time with stable retention of the payload and its accumulation in tumors with high vascular permeability both result in important advantages over conventional chemotherapy...
November 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/27863668/nanotechnologies-for-the-treatment-of-colon-cancer-from-old-drugs-to-new-hope
#2
Larissa Kotelevets, Eric Chastre, Didier Desmaële, Patrick Couvreur
Colorectal cancer is a wide-reaching health problem due to its incidence and to the high mortality rates. Adjuvant chemotherapies have considerably improved the prognosis and/or the overall survival of patients with locally advanced and metastatic cancers. Nevertheless, their efficiency remains limited due to intrinsic and emerging multidrug resistance (MDR) of cancer cells, and to major adverse effects and dose limiting toxicities. The present review discusses the knowledge of clinically relevant mechanisms of resistance to cytotoxic and targeted therapies for the treatment of colorectal cancer, and focuses on the benefit of nanomedicine approach to circumvent these processes...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27858045/droplet-microfluidics-towards-the-assembly-of-advanced-building-blocks-in-cell-mimicry
#3
Ana Armada-Moreira, Essi Taipaleenmäki, Fabian Itel, Yan Zhang, Brigitte Städler
Therapeutic cell mimicry is an approach in nanomedicine aiming at substituting for missing or lost cellular functions employing nature-inspired concepts. Pioneered decades ago, only now is this technology empowered with the arsenal of nanotechnological tools and ready to provide radically new solutions such as assembling synthetic organelles and artificial cells. One of these tools is droplet microfluidics (D-μF), which provides the flexibility to generate cargo-loaded particles with tunable size and shape in a fast and reliable manner, an essential requirement in cell mimicry...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27834398/cancer-nanomedicine-progress-challenges-and-opportunities
#4
Jinjun Shi, Philip W Kantoff, Richard Wooster, Omid C Farokhzad
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a new paradigm in cancer therapy stem from the complexities and heterogeneity of tumour biology, an incomplete understanding of nano-bio interactions and the challenges regarding chemistry, manufacturing and controls required for clinical translation and commercialization...
November 11, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27826368/native-and-reconstituted-plasma-lipoproteins-in-nanomedicine-physicochemical-determinants-of-nanoparticle-structure-stability-and-metabolism
#5
Henry J Pownall, Corina Rosales, Baiba K Gillard, Mauro Ferrari
Although many acute and chronic diseases are managed via pharmacological means, challenges remain regarding appropriate drug targeting and maintenance of therapeutic levels within target tissues. Advances in nanotechnology will overcome these challenges through the development of lipidic particles, including liposomes, lipoproteins, and reconstituted high-density lipoproteins (rHDL) that are potential carriers of water-soluble, hydrophobic, and amphiphilic molecules. Herein we summarize the properties of human plasma lipoproteins and rHDL, identify the physicochemical determinants of lipid transfer between phospholipid surfaces, and discuss strategies for increasing the plasma half-life of lipoprotein- and liposome-associated molecules...
September 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/27822601/nanomaterial-drug-products-manufacturing-and-analytical-perspectives
#6
Christie M Sayes, Grace V Aquino, Anthony J Hickey
The increasing use of nanotechnology, including nanoparticles, in the preparation of drug products requires both manufacturing and analytical considerations in order to establish the quality metrics suitable for performance and risk assessment. A range of different nanoparticle systems exists including (but not limited to) nano-drugs, nano-additives, and nano-carriers. These systems generally require more complex production and characterization strategies than conventional pharmaceutical dosage forms. The advantage of using nanoparticle systems in pharmaceutical science is that the effective and desired function of the material can be designed through modern manufacturing processes...
November 7, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27821998/nanotechnology-in-orthopedics
#7
REVIEW
Roja Garimella, Adam E M Eltorai
Nanotechnology has revolutionized science and consumer products for several decades. Most recently, its applications to the fields of medicine and biology have improved drug delivery, medical diagnostics, and manufacturing. Recent research of this modern technology has demonstrated its potential with novel forms of disease detection and intervention, particularly within orthopedics. Nanomedicine has transformed orthopedics through recent advances in bone tissue engineering, implantable materials, diagnosis and therapeutics, and surface adhesives...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27816266/pharmaceutical-amorphous-nanoparticles
#8
REVIEW
Rajan Jog, Diane J Burgess
There has been a tremendous revolution in the field of nanotechnology, resulting in the advent of novel drug delivery systems known as nanomedicines for diagnosis and therapy. One of the applications is nanoparticulate drug delivery systems which are used to improve the solubility and oral bioavailability of poorly soluble compounds. This is particularly important because most of the molecules emerging from the drug discovery pipeline in recent years have problems associated with solubility and bioavailability...
November 2, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27807501/multimodality-imaging-in-nanomedicine-and-nanotheranostics
#9
Xue Li, Xue-Ning Zhang, Xiao-Dong Li, Jin Chang
Accurate diagnosis of tumors needs much detailed information. However, available single imaging modality cannot provide complete or comprehensive data. Nanomedicine is the application of nanotechnology to medicine, and multimodality imaging based on nanoparticles has been receiving extensive attention. This new hybrid imaging technology could provide complementary information from different imaging modalities using only a single injection of contrast agent. In this review, we introduce recent developments in multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27796139/a-celebration-of-the-contributions-of-professor-pieter-cullis-to-the-fields-of-membrane-biophysics-nanotechnology-and-nanomedicine
#10
Theresa M Allen
No abstract text is available yet for this article.
October 31, 2016: Journal of Drug Targeting
https://www.readbyqxmd.com/read/27795549/nanomedicines-for-renal-disease-current-status-and-future-applications
#11
REVIEW
Nazila Kamaly, John C He, Dennis A Ausiello, Omid C Farokhzad
Treatment and management of kidney disease currently presents an enormous global burden, and the application of nanotechnology principles to renal disease therapy, although still at an early stage, has profound transformative potential. The increasing translation of nanomedicines to the clinic, alongside research efforts in tissue regeneration and organ-on-a-chip investigations, are likely to provide novel solutions to treat kidney diseases. Our understanding of renal anatomy and of how the biological and physico-chemical properties of nanomedicines (the combination of a nanocarrier and a drug) influence their interactions with renal tissues has improved dramatically...
December 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27776214/advances-in-molecular-modeling-of-nanoparticle-nucleic-acid-interfaces
#12
Jessica A Nash, Albert L Kwansa, James Samuel Peerless, Ho Shin Kim, Yaroslava G Yingling
Nanoparticles (NPs) play increasingly important roles in nanotechnology and nanomedicine where nanoparticle surface chemistry allows for control over interactions with other nanoparticles and biomolecules. In particular, for applications in drug and gene delivery, a fundamental understanding of the NP-nucleic acid interface allows for development of more efficient and effective nanoparticle carriers. Computational modeling can provide insights of processes occurring at the inorganic NP-nucleic interface, in detail which is difficult to access by experimental methods...
October 24, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27766216/nanomedicine-in-central-nervous-system-cns-disorders-a-present-and-future-prospective
#13
Shringika Soni, Rakesh Kumar Ruhela, Bikash Medhi
Purpose: For the past few decades central nervous system disorders were considered as a major strike on human health and social system of developing countries. The natural therapeutic methods for CNS disorders limited for many patients. Moreover, nanotechnology-based drug delivery to the brain may an exciting and promising platform to overcome the problem of BBB crossing. In this review, first we focused on the role of the blood-brain barrier in drug delivery; and second, we summarized synthesis methods of nanomedicine and their role in different CNS disorder...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27752975/highly-aqueous-soluble-caf2-ce-tb-nanocrystals-effect-of-surface-functionalization-on-structural-optical-band-gap-and-photoluminescence-properties
#14
Anees A Ansari, Abdul K Parchur, Brijesh Kumar, S B Rai
The design of nanostructured materials with highly stable water-dispersion and luminescence efficiency is an important concern in nanotechnology and nanomedicine. In this paper, we described the synthesis and distinct surface modification on the morphological structure and optical (optical absorption, band gap energy, excitation, emission, decay time, etc.) properties of highly crystalline water-dispersible CaF2:Ce/Tb nanocrystals (core-nanocrystals). The epitaxial growth of inert CaF2 and silica shell, respectively, on their surface forming as CaF2:Ce/Tb@CaF2 (core/shell) and CaF2:Ce/Tb@CaF2@SiO2 (core/shell/SiO2) nanoarchitecture...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27745949/environmental-behaviour-and-ecotoxicity-of-quantum-dots-at-various-trophic-levels-a-review
#15
Thiago Lopes Rocha, Nélia C Mestre, Simone Maria Teixeira Sabóia-Morais, Maria João Bebianno
Despite the wide application of quantum dots (QDs) in electronics, pharmacy and nanomedicine, limited data is available on their environmental health risk. To advance our current understanding of the environmental impact of these engineered nanomaterials, the aim of this review is to give a detailed insight on the existing information concerning the behaviour, transformation and fate of QDs in the aquatic environment, as well as on its mode of action (MoA), ecotoxicity, trophic transfer and biomagnification at various trophic levels (micro-organisms, aquatic invertebrates and vertebrates)...
October 13, 2016: Environment International
https://www.readbyqxmd.com/read/27735003/mito-magneto-a-tool-for-nanoparticle-mediated-mitochondria-isolation
#16
Bhabatosh Banik, Brett W Askins, Shanta Dhar
The field of intracellular organelle targeting using nanoparticle (NP) is mushrooming rapidly. Thus, the area of nanotechnology-enabled targeting of mitochondrion, the cellular powerhouse, for diseases characterized by mitochondrial dysfunctions such as cancer, diseases of the central nervous system, and cardiovascular diseases is also growing at a rapid pace. Optimization of a NP's ability to target the mitochondria requires quantification of the particles in this subcellular organelle and isolation of mitochondria from the cells...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27722328/reactive-oxygen-species-generating-systems-meeting-challenges-of-photodynamic-cancer-therapy
#17
REVIEW
Zijian Zhou, Jibin Song, Liming Nie, Xiaoyuan Chen
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, a photosensitizer (PS) and oxygen, which greatly favors the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) the limited penetration depth of light, which restricts traditional PDT to superficial tumours; (ii) oxygen reliance does not allow PDT treatment of hypoxic tumours; (iii) light can complicate the phototherapeutic outcomes because of the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects from undesirable white-light activation and self-catalysation of traditional PSs...
November 21, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27709137/recent-trends-on-hydrogel-based-drug-delivery-systems-for-infectious-diseases
#18
Arti Vashist, Ajeet Kaushik, Atul Vashist, Rahul Dev Jayant, Asahi Tomitaka, Sharif Ahmad, Y K Gupta, Madhavan Nair
Since centuries, the rapid spread and cure of infectious diseases have been a major concern to the progress and survival of humans. These diseases are a global burden and the prominent cause for worldwide deaths and disabilities. Nanomedicine has emerged as the most excellent tool to eradicate and halt their spread. Various nanoformulations (NFs) using advanced nanotechnology are in demand. Recently, hydrogel and nanogel based drug delivery devices have posed new prospects to simulate the natural intelligence of various biological systems...
October 18, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27703233/biomimetic-carriers-mimicking-leukocyte-plasma-membrane-to-increase-tumor-vasculature-permeability
#19
R Palomba, A Parodi, M Evangelopoulos, S Acciardo, C Corbo, E de Rosa, I K Yazdi, S Scaria, R Molinaro, N E Toledano Furman, J You, M Ferrari, F Salvatore, E Tasciotti
Recent advances in the field of nanomedicine have demonstrated that biomimicry can further improve targeting properties of current nanotechnologies while simultaneously enable carriers with a biological identity to better interact with the biological environment. Immune cells for example employ membrane proteins to target inflamed vasculature, locally increase vascular permeability, and extravasate across inflamed endothelium. Inspired by the physiology of immune cells, we recently developed a procedure to transfer leukocyte membranes onto nanoporous silicon particles (NPS), yielding Leukolike Vectors (LLV)...
October 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27682869/diamonds-digital-health-and-drug-development-optimizing-combinatorial-nanomedicine
#20
Dean Ho, Ali Zarrinpar, Edward Kai-Hua Chow
The field of nanomedicine has already seen substantial progress in the clinic, with multiple formulations being evaluated through clinical studies. From poly(lactic-co-glycolic acid) and cyclodextrin-based drug-delivery platforms to metallic nanoparticles for photothermal treatment and imaging, nanotechnology has enabled versatile strategies to treat and to diagnose a wide range of disorders. However, as the field as a whole pushes forward, barriers that have always challenged conventional drug development have already started to impact nanomedicine translation...
September 28, 2016: ACS Nano
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