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https://www.readbyqxmd.com/read/29662451/risk-assessment-and-risk-minimization-in-nanomedicine-a-need-for-predictive-alternative-and-3rs-strategies
#1
REVIEW
Lisa Accomasso, Caterina Cristallini, Claudia Giachino
The use of nanomaterials in medicine has grown very rapidly, leading to a concern about possible health risks. Surely, the application of nanotechnology in medicine has many significant potentialities as it can improve human health in at least three different ways: by contributing to early disease diagnosis, improved treatment outcomes and containment of health care costs. However, toxicology or safety assessment is an integral part of any new medical technology and the nanotechnologies are no exception. The principle aim of nanosafety studies in this frame is to enable safer design of nanomedicines...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29661045/recent-approaches-for-targeted-drug-delivery-in-rheumatoid-arthritis-diagnosis-and-treatment
#2
Sana Pirmardvand Chegini, Jaleh Varshosaz, Somayeh Taymouri
Rheumatoid arthritis (RA) is a chronic inflammatory disease with complex pathology characterized by inflammation of joints, devastation of the synovium, pannus formation, bones and cartilage destruction and often is associated with persistent arthritic pain, swelling, stiffness and work disability. In conventional RA therapy, because of short biological half-life, poor bioavailability, high and frequent dosing is required. Thereby, these anti-RA medications, which unable to selectively target affected zone, may cause severe side effects in extra-articular tissues...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29602957/nanotechnology-the-scope-and-potential-applications-in-orthopedic-surgery
#3
EDITORIAL
Ashok Gavaskar, D Rojas, F Videla
Nanotechnology involves manipulation of matter measuring 1-100 nm in at least one of its dimensions at the molecular level. Engineering and manipulation of matter at the molecular level has several advantages in the field of medicine (nanomedicine) since most of the biological molecules exist and function at a nanoscale. Though promising, questions still remain on how much of this will ultimately translate into achieving better patient care. Concerns of cost-effectiveness and nanotechnology safety still remain unclear...
March 30, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29602254/nanomedicine-approaches-against-parasitic-worm-infections
#4
REVIEW
Pengyang Li, Pamela E Rios Coronado, Xóchitl R R Longstaff, Alexander J Tarashansky, Bo Wang
Nanomedicine approaches have the potential to transform the battle against parasitic worm (helminth) infections, a major global health scourge from which billions are currently suffering. It is anticipated that the intersection of two currently disparate fields, nanomedicine and helminth biology, will constitute a new frontier in science and technology. This progress report surveys current innovations in these research fields and discusses research opportunities. In particular, the focus is on: (1) major challenges that helminth infections impose on mankind; (2) key aspects of helminth biology that inform future research directions; (3) efforts to construct nanodelivery platforms to target drugs and genes to helminths hidden in their hosts; (4) attempts in applying nanotechnology to enable vaccination against helminth infections; (5) outlooks in utilizing nanoparticles to enhance immunomodulatory activities of worm-derived factors to cure allergy and autoimmune diseases...
March 30, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29582476/cell-membrane-coating-nanotechnology
#5
REVIEW
Ronnie H Fang, Ashley V Kroll, Weiwei Gao, Liangfang Zhang
Nanoparticle-based therapeutic, prevention, and detection modalities have the potential to greatly impact how diseases are diagnosed and managed in the clinic. With the wide range of nanomaterials available, the rational design of nanocarriers on an application-specific basis has become increasingly commonplace. Here, a comprehensive overview is provided on an emerging platform: cell-membrane-coating nanotechnology. As a fundamental unit of biology, cells carry out a wide range of functions, including the remarkable ability to interface and interact with their surrounding environment...
March 27, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29567397/nanopharmaceuticals-for-wound-healing-lost-in-translation
#6
Mukul Ashtikar, Matthias G Wacker
Today, many of the newly developed pharmaceuticals and medical devices take advantage of nanotechnology and with a rising incidence of chronic diseases such as diabetes and cardiovascular disease, the number of patients afflicted globally with non-healing wounds is growing. This has created a requirement for improved therapies and wound care. However, converting the strategies applied in early research into new products is still challenging. Many of them fail to comply with the market requirements. This review discusses the legal and scientific challenges in the design of nanomedicines for wound healing...
March 19, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29559165/debugging-nano-bio-interfaces-systematic-strategies-to-accelerate-clinical-translation-of-nanotechnologies
#7
REVIEW
Morteza Mahmoudi
Despite considerable efforts in the field of nanomedicine that have been made by researchers, funding agencies, entrepreneurs, and the media, fewer nanoparticle (NP) technologies than expected have made it to clinical trials. The wide gap between the efforts and effective clinical translation is, at least in part, due to multiple overlooked factors in both in vitro and in vivo environments, a poor understanding of the nano-bio interface, and misinterpretation of the data collected in vitro, all of which reduce the accuracy of predictions regarding the NPs' fate and safety in humans...
March 17, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29545106/size-shrinkable-drug-delivery-nanosystems-and-priming-the-tumor-microenvironment-for-deep-intratumoral-penetration-of-nanoparticles
#8
REVIEW
Yimin Niu, Jianhua Zhu, Yang Li, Huihui Shi, Yaxiang Gong, Rui Li, Qiang Huo, Tao Ma, Yang Liu
The penetration of nanomedicine into solid tumor still constitutes a great challenge for cancer therapy, which lead to the failure of thorough clearance of tumor cells. Aiming at solving this issue, lots of encouraging progress has been made in the development of multistage nanoparticles triggered by various stimuli in the past few years. Besides, the therapeutical effects of nanoagents are also greatly impacted by the complex tumor microenvironment, and remodeling tumor microenvironment has become another important approach for promoting nanoparticles penetration...
March 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29528075/recent-advances-in-anti-angiogenic-nanomedicines-for-cancer-therapy
#9
Pravin Bhattarai, Sadaf Hameed, Zhifei Dai
Angiogenesis is a normal physiological remodeling process initiated at the time of embryonic development and lessened with the progress of time. Nevertheless, continuous activation of stringent signaling pathways and proangiogenic factors during tumorigenesis (a pathological condition) instigates serious vessel abnormalities eliciting severe therapeutic inefficiency. In principle, systemic delivery of robust antiangiogenic drugs often fails to reach these abnormal tumor vessels depicting poor pharmacokinetics, biodistribution profiles and adverse side effects in vivo...
March 28, 2018: Nanoscale
https://www.readbyqxmd.com/read/29512450/pharmacokinetics-metabolism-distribution-and-permeability-of-nanomedicine
#10
Selvan Ravindran, Jitendra Kumar Suthar, Rutuja Rokade, Pooja Deshpande, Pooja Singh, Ashutosh Pratinidhi, Rajeshree Khambadkhar, Srushti Utekar
Background Medical application of nanotechnology is termed as Nanomedicine and is widely used in healthcare industries. Nanotechnology has helped Physicians, Scientists and Technologists to understand the changes in cellular levels to develop nanomedicines and address the challenges faced by the healthcare sectors. Nanoparticles with less than 1nm in size have been used as drug delivery and gene delivery systems to accelerate the drug action in humans. Size of nanomaterials is akin to that of biomolecules and expected to have better interactions...
March 5, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29510526/nanotechnology-and-glycosaminoglycans-paving-the-way-forward-for-ovarian-cancer-intervention
#11
REVIEW
Yasar Hoosen, Priyamvada Pradeep, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Viness Pillay
Ovarian cancer (OC) has gained a great deal of attention due to its aggressive proliferative capabilities, high death rates and poor treatment outcomes, rendering the disease the ultimate lethal gynaecological cancer. Nanotechnology provides a promising avenue to combat this malignancy by the niche fabrication of optimally-structured nanomedicines that ensure potent delivery of chemotherapeutics to OC, employing nanocarriers to act as "intelligent" drug delivery vehicles, functionalized with active targeting approaches for precision delivery of chemotherapeutics to overexpressed biomarkers on cancer cells...
March 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29509403/recent-advances-of-membrane-cloaked-nanoplatforms-for-biomedical-applications
#12
Bengang Xing, Xiangzhao Ai, Ming Hu, Zhimin Wang, Wenmin Zhang, Juan Li, Jun Lin, Huang-Hao Yang
In terms of the extremely small size and large specific surface area, nanomaterials often exhibit unusual physical and chemical properties, which have recently attracted considerable attention in bionanotechnology and nanomedicine. Currently, the extensive usage of nanotechnology in medicine holds the great potential for precise diagnosis and effective therapeutics of various human diseases in clinical practice in past decades. However, a detailed understanding regarding how nanomedicines interact with the intricate environment in complex living systems remains a pressing and challenging goal...
March 6, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29467575/nanoscale-polysaccharide-derivative-as-an-aeg-1-sirna-carrier-for-effective-osteosarcoma-therapy
#13
Fen Wang, Jia-Dong Pang, Lei-Lei Huang, Ran Wang, Dan Li, Kang Sun, Lian-Tang Wang, Li-Ming Zhang
Background: Nanomedicine, which is the application of nanotechnology in medicine to make medical diagnosis and treatment more accurate, has great potential for precision medicine. Despite some improvements in nanomedicine, the lack of efficient and low-toxic vectors remains a major obstacle. Objective: The aim of this study was to prepare an efficient and low-toxic vector which could deliver astrocyte elevated gene-1 ( AEG-1 ) small interfering RNA (siRNA; siAEG-1) into osteosarcoma cells effectively and silence the targeted gene both in vitro and in vivo...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29465222/dna-nanotechnology-enabled-drug-delivery-systems
#14
Qinqin Hu, Hua Li, Lihua Wang, Hongzhou Gu, Chunhai Fan
Over the past decade, we have seen rapid advances in applying nanotechnology in biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging field, DNA nanotechnology offers simple yet powerful design techniques for self-assembly of nanostructures with unique advantages and high potential in enhancing drug targeting and reducing drug toxicity. Various sequence programming and optimization approaches have been developed to design DNA nanostructures with precisely engineered, controllable size, shape, surface chemistry, and function...
February 21, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29464309/nanotechnology-in-plants
#15
Ismail Ocsoy, Didar Tasdemir, Sumeyye Mazicioglu, Weihong Tan
The integration of nanotechnology in medicine has had a tremendous impact in the past few decades. The discovery of synthesis of nanomaterials (NMs) and their functions as versatile tools promoted various applications in nano-biotechnology and nanomedicine. Although the physical and chemical methods are still considered as commonly used methods, they introduce several drawbacks such as the use of toxic chemicals (solvent, reducing, and capping agents) and poor control of size, size distribution, and morphology, respectively...
February 21, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29461122/synchronous-delivery-of-oxygen-and-photosensitizer-for-alleviation-of-hypoxia-tumor-microenvironment-and-dramatically-enhanced-photodynamic-therapy
#16
Xiaomeng Guo, Jiaxin Qu, Chunqi Zhu, Wei Li, Lihua Luo, Jie Yang, Xiaoyi Yin, Qingpo Li, Yongzhong Du, Dawei Chen, Yunqing Qiu, Yan Lou, Jian You
Photosensitizer, proper laser irradiation, and oxygen are essential components for effective photodynamic therapy (PDT) in clinical cancer therapy. However, native hypoxic tumoral microenvironment is a major barrier hindering photodynamic reactions in vivo. Thus, we have prepared biocompatible liposomes by loading complexes of oxygen-carrier (hemoglobin, Hb) and photosensitizer (indocyanine green, ICG) for enhanced PDT against hypoxic tumor. Ideal oxygen donor Hb, which is an oxygen-carried protein in red blood cells, makes such liposome which provide stable oxygen supply...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29458568/nanoformulations-for-targeted-drug-delivery-to-prostate-cancer-an-overview
#17
Soundararajan Hema, Selvarathinam Thambiraj, Dhesingh Ravi Shankaran
Cancer is the second leading causes of death worldwide and it is one of the fatal diseases that kill millions of people every year. It is characterized by uncontrolled proliferation of cells and loss of apoptosis that generates an abnormal mass of cells or tumors. Prostate cancer (PCa) is one of the most common cancers in men and the risk is higher over the age of 55-65. Currently, PCa is the second most common cancer, which causes death in men has a high prevalence with relatively lower cancer mortality risk compared to lung and colon cancer...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29454063/characterization-of-nanomedicines-a-reflection-on-a-field-under-construction-needed-for-clinical-translation-success
#18
REVIEW
Jean-Baptiste Coty, Christine Vauthier
The nanotechnology revolution offers many expectations for the improvement of medicine treatments. At present, nanomedicine (NM) development is hampered by methodological barriers for a better characterization and a wider understanding of their in vivo behavior. While regulatory agencies setup guidelines to support NM translation from bench to bedside, the gap is still hardly overcome by main nanomedicines. One lever for filling this gap is a better characterization, thus increasing the global knowledge about the NM itself but also validate the confidence in terms of batch to batch reproducibility of such complex nano-objects...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29450964/imparting-designer-biorecognition-functionality-to-metal-organic-frameworks-by-a-dna-mediated-surface-engineering-strategy
#19
Weiyu Ning, Zhenghan Di, Yingjie Yu, Pingmei Zeng, Chunzhi Di, Daquan Chen, Xueqian Kong, Guangjun Nie, Yuliang Zhao, Lele Li
Surface functionality is an essential component for processing and application of metal-organic frameworks (MOFs). A simple and cost-effective strategy for DNA-mediated surface engineering of zirconium-based nanoscale MOFs (NMOFs) is presented, capable of endowing them with specific molecular recognition properties and thus expanding their potential for applications in nanotechnology and biotechnology. It is shown that efficient immobilization of functional DNA on NMOFs can be achieved via surface coordination chemistry...
February 16, 2018: Small
https://www.readbyqxmd.com/read/29447018/summary-of-numerical-analyses-for-therapeutic-uses-of-laser-activated-gold-nanoparticles
#20
Jakub Mesicek, Kamil Kuca
The optimal light dose, heat generation, consequent heat spread, and an accurate thermal damage model, are key components of effective laser therapies. Recent advances in nanotechnology offer numerous possibilities on how to increase the efficacy of hyperthermia for tumour treatments. Gold nanoparticles are a promising candidate towards the achievement of this goal owing to their properties for efficiently converting light to heat. In this review, we summarise the numerical tools that are available for theoretical studies of gold-nanoparticle-mediated photo-thermal therapy...
February 15, 2018: International Journal of Hyperthermia
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