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Nanomedicine nanotechnology

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https://www.readbyqxmd.com/read/29454063/characterization-of-nanomedicines-a-reflection-on-a-field-under-construction-needed-for-clinical-translation-success
#1
REVIEW
Jean-Baptiste Coty, Christine Vauthier
The nanotechnology revolution offers many expectations for the improvement of medicine treatments. At present, nanomedicine (NM) development is hampered by methodological barriers for a better characterization and a wider understanding of their in vivo behavior. While regulatory agencies setup guidelines to support NM translation from bench to bedside, the gap is still hardly overcome by main nanomedicines. One lever for filling this gap is a better characterization, thus increasing the global knowledge about the NM itself but also validate the confidence in terms of batch to batch reproducibility of such complex nano-objects...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29450964/imparting-designer-biorecognition-functionality-to-metal-organic-frameworks-by-a-dna-mediated-surface-engineering-strategy
#2
Weiyu Ning, Zhenghan Di, Yingjie Yu, Pingmei Zeng, Chunzhi Di, Daquan Chen, Xueqian Kong, Guangjun Nie, Yuliang Zhao, Lele Li
Surface functionality is an essential component for processing and application of metal-organic frameworks (MOFs). A simple and cost-effective strategy for DNA-mediated surface engineering of zirconium-based nanoscale MOFs (NMOFs) is presented, capable of endowing them with specific molecular recognition properties and thus expanding their potential for applications in nanotechnology and biotechnology. It is shown that efficient immobilization of functional DNA on NMOFs can be achieved via surface coordination chemistry...
February 16, 2018: Small
https://www.readbyqxmd.com/read/29447018/summary-of-numerical-analyses-for-therapeutic-uses-of-laser-activated-gold-nanoparticles
#3
Jakub Mesicek, Kamil Kuca
The optimal light dose, heat generation, consequent heat spread, and an accurate thermal damage model, are key components of effective laser therapies. Recent advances in nanotechnology offer numerous possibilities on how to increase the efficacy of hyperthermia for tumour treatments. Gold nanoparticles are a promising candidate towards the achievement of this goal owing to their properties for efficiently converting light to heat. In this review, we summarise the numerical tools that are available for theoretical studies of gold-nanoparticle-mediated photo-thermal therapy...
February 15, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29441706/new-strategies-in-the-design-of-nanomedicine-to-oppose-uptake-by-the-mononuclear-phagocyte-system-for-enhancing-cancer-therapeutic-efficacy
#4
Yiming Zhou, Zhifei Dai
The application of nanotechnology in tumor treatment has boomed the vigorous development in cancer nanomedicine. In spite of the great success has been achieved in this field, the nanomedicine has not realized its full potential owing to a delivery barrier, the mononuclear phagocytic system (MPS), which cuts off more than 95 % of the administrated nanoparticles. This results in an extremely low drug delivery efficacy to the tumor, leading to poor therapeutic outcomes. Moreover, the excessive injection of nanoparticles also raises toxicity concern caused by the accumulation of nanomaterials in the organs like liver and spleen...
February 13, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29436157/precision-engineering-of-targeted-nanocarriers
#5
REVIEW
Michael B Deci, Maixian Liu, Quoc Thai Dinh, Juliane Nguyen
Since their introduction in 1980, the number of advanced targeted nanocarrier systems has grown considerably. Nanocarriers capable of targeting single receptors, multiple receptors, or multiple epitopes have all been used to enhance delivery efficiency and selectivity. Despite tremendous progress, preclinical studies and clinically translatable nanotechnology remain disconnected. The disconnect in targeting efficacy may stem from poorly-understood factors such as receptor clustering, spatial control of targeting ligands, ligand mobility, and ligand architecture...
February 13, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29422412/nanotechnology-based-strategies-for-sirna-brain-delivery-for-disease-therapy
#6
REVIEW
Meng Zheng, Wei Tao, Yan Zou, Omid C Farokhzad, Bingyang Shi
Small interfering RNA (siRNA)-based gene silencing technology has demonstrated significant potential for treating brain-associated diseases. However, effective and safe systemic delivery of siRNA into the brain remains challenging because of biological barriers such as enzymatic degradation, short circulation lifetime, the blood-brain barrier (BBB), insufficient tissue penetration, cell endocytosis, and cytosolic transport. Nanotechnology offers intriguing potential for addressing these challenges in siRNA brain delivery in conjunction with chemical and biological modification strategies...
February 5, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29418076/viral-based-nanomaterials-for-plasmonic-and-photonic-materials-and-devices
#7
REVIEW
Dan Stefan Petrescu, Amy Szuchmacher Blum
Over the last decade, viruses have established themselves as a powerful tool in nanotechnology. Their proteinaceous capsids benefit from biocompatibility, chemical addressability, and a variety of sizes and geometries, while their ability to encapsulate, scaffold, and self-assemble enables their use for a wide array of purposes. Moreover, the scaling up of viral-based nanotechnologies is facilitated by high capsid production yield and speed, which is particularly advantageous when compared with slower and costlier lithographic techniques...
February 8, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29412103/nanotechnology-inspired-advanced-engineering-fundamentals-for-optimizing-drug-delivery
#8
Ahmed Alaa Kassem
BACKGROUND: Drug toxicity and inefficacy are commonly experienced problems with drug therapy failure. To face these problems, extensive research work took place aiming to design new dosage forms for drug delivery especially nanoparticulate systems. These systems are designed to increase the quantity of the therapeutic molecule delivered to the desired site concurrently with reduced side effects. In order to achieve this objective, nanocarriers must principally display suitable drug vehiculization abilities and a controlled biological destiny of drug molecules...
February 6, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29391232/multifunctional-nanoparticles-for-cancer-immunotherapy-a-groundbreaking-approach-for-reprogramming-malfunctioned-tumor-environment
#9
REVIEW
Samaresh Sau, Hashem O Alsaab, Ketki Bhise, Rami Alzhrani, Ghazal Nabil, Arun K Iyer
Several cancer immunotherapy approaches have been recently introduced into the clinics and they have shown remarkable therapeutic potentials. The groundbreaking cancer immunotherapeutic agents function as a stimulant or modulator of the body immune system to fight against or kill cancers. Although targeted immunotherapies such as immune check point inhibitors (CTLA-4 or PD-1/PD-L1), DNA vaccination and CAR-T therapy are revolutionizing cancer treatment, the delivery efficacy can be further improved while their off-target toxicity can be mitigated through nanotechnology approaches...
January 29, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29381129/are-existing-standard-methods-suitable-for-the-evaluation-of-nanomedicines-some-case-studies
#10
Sabrina Gioria, Fanny Caputo, Patricia Urbán, Ciarán Manus Maguire, Susanne Bremer-Hoffmann, Adriele Prina-Mello, Luigi Calzolai, Dora Mehn
The use of nanotechnology in medical products has been demonstrated at laboratory scale, and many resulting nanomedicines are in the translational phase toward clinical applications, with global market trends indicating strong growth of the sector in the coming years. The translation of nanomedicines toward the clinic and subsequent commercialization may require the development of new or adaptation of existing standards to ensure the quality, safety and efficacy of such products. This work addresses some identified needs, and illustrates the shortcomings of currently used standardized methods when applied to medical-nanoparticles to assess particle size, drug loading, drug release and in vitro safety...
January 30, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29363798/evolution-of-structural-dna-nanotechnology
#11
REVIEW
Sami Nummelin, Juhana Kommeri, Mauri A Kostiainen, Veikko Linko
The research field entitled structural DNA nanotechnology emerged in the beginning of the 1980s as the first immobile synthetic nucleic acid junctions were postulated and demonstrated. Since then, the field has taken huge leaps toward advanced applications, especially during the past decade. This Progress Report summarizes how the controllable, custom, and accurate nanostructures have recently evolved together with powerful design and simulation software. Simultaneously they have provided a significant expansion of the shape space of the nanostructures...
January 24, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29357234/biomimetic-nanosponges-for-treating-antibody-mediated-autoimmune-diseases
#12
Yao Jiang, Ronnie H Fang, Liangfang Zhang
Autoimmune diseases are characterized by overactive immunity, where the body's defense system launches an attack against itself. If left unchecked, this can result in the destruction of healthy tissue and significantly affect patient wellbeing. In the case of type II autoimmune hypersensitivities, autoreactive antibodies attack the host's own cells or extracellular matrix. Current clinical treatment modalities for managing this class of disease are generally nonspecific and face considerable limitations. In this review, we cover emerging therapeutic strategies, with an emphasis on novel nanomedicine platforms...
January 22, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29355619/nanotherapeutics-in-oral-and-parenteral-drug-delivery-key-learnings-and-future-outlooks-as-we-think-small
#13
REVIEW
Puneet Tyagi, J Anand Subramony
Nanotechnology ushered the field of medicine in to a new era. Miniaturization, increased surface area, and the unique physicochemical properties in the nano dimension were explored for new applications. Pharmaceutical industry picked up the technology and early success came fast for oral drug delivery through improvement in dissolution properties of the active molecules. Many products were launched using the nanocrystal technology on the oral side. Further development of polymeric nanoparticles led to wide spread research of nanocarriers for parenteral delivery...
January 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29339248/recent-trends-of-nanomedicinal-approaches-in-clinics
#14
REVIEW
Fahima Dilnawaz, Sarbari Acharya, Sanjeeb Kumar Sahoo
Nanotechnology has become the indispensable cutting edge science providing solutions to many problems associated with human being. The application of nanotechnology associated to human health "nanomedicine" has revolutionized the drug delivery system by providing improved pharmacological and therapeutic properties of drugs. These advantageous effects of drug loaded nanocarrier systems are embraced by the pharmaceutical industries for the development of different effective nanocarriers. Currently, several drug loaded nanoformulations are approved by the Food and Drug Administration (FDA), and some of them are undergoing clinical trials for the human use...
January 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29333658/in-situ-shrna-synthesis-on-dna-polylactide-nanoparticles-to-treat-multidrug-resistant-breast-cancer
#15
Qianqian Ni, Fuwu Zhang, Yunlei Zhang, Guizhi Zhu, Zhe Wang, Zhaogang Teng, Chunyan Wang, Bryant C Yung, Gang Niu, Guangming Lu, Longjiang Zhang, Xiaoyuan Chen
Nanomedicine has shown unprecedented potential for cancer theranostics. Nucleic acid (e.g., DNA and RNA) nanomedicines are of particular interest for combination therapy with chemotherapeutics. However, current nanotechnologies to construct such nucleic acid nanomedicines, which rely on chemical conjugation or physical complexation of nucleic acids with chemotherapeutics, have restrained their clinical translation due to limitations such as low drug loading efficiency and poor biostability. Herein, in situ rolling circle transcription (RCT) is applied to synthesize short hairpin RNA (shRNA) on amphiphilic DNA-polylactide (PLA) micelles...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29332566/stimuli-responsive-nanoparticles-for-controlled-anti-cancer-drug-release
#16
Qi Tang, Bing Yu, Lilong Gao, Hailin Cong, Na Song, Chenghao Lu
Conventional drugs used for cancer chemotherapy have severe toxic side effects and show individually varied therapeutic responses. The convergence of nanotechnology, biology, material science and pharmacy offers a perspective strategy for cancer chemotherapy. Nanoparticles loaded with anti-cancer drug have been designed to overcome the limitations associated with conventional drugs, several nanomedicines have been approved by FDA and shown good performances in clinical practice. However, the therapeutic efficacies cannot be enhanced...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29318963/nanodiagnostics-and-nanodelivery-applications-in-genetic-alterations
#17
Maria Sofia Falzarano, Cristina Flesia, Roberta Cavalli, Caterina Guiot, Alessandra Ferlini
Background Genetic alterations cause hereditary diseases (HDs) with a wide range of incidences. Some, like cystic fibrosi, occur frequently (1/1,000 newborns), whilst others, such as Pompe disease and other metabolic disorders are very rare (1/100,000 newborns). They are well under the threshold of 1/3,000, denoted by the European Community as rare diseases (RDs). Genetic alterations are also associated with multifactorial disorders like diabetes, and underline both somatic and germline mutations in cancer...
January 10, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29290280/nanomedicine-an-emerging-therapeutic-strategy-for-oral-cancer-therapy
#18
REVIEW
Sabrina Marcazzan, Elena Maria Varoni, Elvin Blanco, Giovanni Lodi, Mauro Ferrari
Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therapeutic advances in cancer. Indeed, several platforms have been clinically approved for cancer therapy, while other promising systems are undergoing exploration in clinical trials. With its ability to deliver drugs, nucleic acids, and MRI contrast agents with high efficiency, nanomedicine platforms offer the potential to improve drug efficacy and tolerability...
January 2018: Oral Oncology
https://www.readbyqxmd.com/read/29261332/nanomedicine-for-immunosuppressive-therapy-achievements-in-pre-clinical-and-clinical-research
#19
Hanan Al-Lawati, Hamidreza Montazeri Aliabadi, Behzad Sharif MakhmalZadeh, Afsaneh Lavasanifar
Immunosuppression has been the mainstay therapy in organ transplantation and autoimmune diseases. Different classes of drugs have been used in such disease conditions, but their effective clinical application has been limited by the emergence of systemic immunosuppression and/or individual drug side effects. Nanotechnology approaches may be used to modify the mentioned shortcomings of immunosuppressive therapy by enhancing the delivery of immunosuppressant to target cells of the immune system, thus reducing the required dose for function, and/or reducing drug distribution to non-target tissues...
December 20, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29246070/propensity-of-a-single-walled-carbon-nanotube-peptide-to-mimic-a-kk10-peptide-in-an-hla-tcr-complex
#20
Mei Feng, David R Bell, Ruhong Zhou
The application of nanotechnology to improve disease diagnosis, treatment, monitoring, and prevention is the goal of nanomedicine. We report here a theoretical study of a functionalized single-walled carbon nanotube (CNT) mimic binding to a human leukocyte antigen-T cell receptor (HLA-TCR) immune complex as a first attempt of a potential nanomedicine for human immunodeficiency virus (HIV) vaccine development. The carbon nanotube was coated with three arginine residues to imitate the HIV type 1 immunodominant viral peptide KK10 (gag 263-272: KRWIILGLNK), named CNT-peptide hereafter...
December 14, 2017: Journal of Chemical Physics
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