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cutanous leishmaniasis treatment

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https://www.readbyqxmd.com/read/28335752/development-of-a-rapid-loop-mediated-isothermal-amplification-assay-for-diagnosis-and-assessment-of-cure-of-leishmania-infection
#1
Sandeep Verma, Ruchi Singh, Vanila Sharma, Ram Avtar Bumb, Narendra Singh Negi, V Ramesh, Poonam Salotra
BACKGROUND: Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel. A robust, rapid and cost effective diagnostic test is warranted for on-time diagnosis and field application. METHODS: We have developed a loop mediated isothermal amplification (LAMP) assay with primers (n = 6) based on Leishmania donovani kDNA for detection of Leishmania infection, using a closed tube to prevent cross-contamination...
March 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28327802/in-vitro-and-in-vivo-antileishmanial-activity-of-artemisia-annua-l-leaf-powder-and-its-potential-usefulness-in-the-treatment-of-uncomplicated-cutaneous-leishmaniasis-in-humans
#2
Luz Estella Mesa, Daniel Vasquez, Pierre Lutgen, Iván Darío Vélez, Adriana María Restrepo, Isabel Ortiz, Sara María Robledo
INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of various diseases in 80% of the global population, the validation of these products is essential. Gelatin capsules containing dried Artemisia annua leaf powder were recently developed as a new herbal formulation (totum) for the oral treatment of malaria and other parasitic diseases...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28281913/rapidly-progressing-facial-leishmaniasis-effective-treatment-with-liposomal-amphotericin-b-and-a-review-of-the-management-of-old-world-cutaneous-leishmaniasis
#3
Shamim Islam
Cutaneous leishmaniasis (CL), a common condition in many parts of the world, is being increasingly encountered in non-endemic countries secondary to immigration. The clinical manifestations and course can vary substantially, with appropriate management ranging from observation for self-healing lesions to urgent treatment to prevent damaging anatomical and cosmetic sequelae. While there are now several effective medications, optimal therapy is not well defined, and decision-making can be challenged by the location of lesions and various drug issues, including availability, mode of delivery and adverse effects...
March 10, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28276641/cost-effectiveness-analysis-of-thermotherapy-versus-pentavalent-antimonials-for-the-treatment-of-cutaneous-leishmaniasis
#4
Jaiberth Antonio Cardona-Arias, Liliana López-Carvajal, Mery Patricia Tamayo Plata, Iván Darío-Vélez
OBJECTIVE: The treatment of cutaneous leishmaniasis is toxic, has contraindications and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. METHODS: Effectiveness was the proportion of healing, and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing were conducted...
February 5, 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28274283/topical-tamoxifen-in-the-therapy-of-cutaneous-leishmaniasis
#5
Cristiana T Trinconi, Juliana Q Reimão, Vivian I Bonano, Caroline R Espada, Danilo C Miguel, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana
The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial combinations in an experimental model of cutaneous leishmaniasis. BALB/c mice infected with a luciferase expressing line of Leishmania amazonensis were treated with topical tamoxifen in two different formulations (ethanol or oil-free cream) as monotherapy or in co-administration with pentavalent antimonial. Treatment efficacy was evaluated by lesion size and parasite burden, quantified through luminescence, at the end of treatment and 4 weeks later...
March 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28263719/mechanism-of-ascaridole-activation-in-leishmania
#6
Gerald Geroldinger, Matthias Tonner, Hubert Hettegger, Markus Bacher, Lianet Monzote, Martin Walter, Katrin Staniek, Thomas Rosenau, Lars Gille
Endoperoxides (EP) are an emerging class of drugs which have potential in antiparasitic therapy, but also in other fields. For malaria therapy the EP artemisinin (Art) and its derivatives are successfully used. We have shown in the past that the EP ascaridole (Asc) is useful for the treatment of cutaneous leishmaniasis in a mouse model. Biomimetic experiments suggested that these drugs need activation in the respective target pathogens to exert their function. In spite of this idea, direct activation of EP to radicals inside cells has never been demonstrated...
March 2, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28251109/effect-of-hydroalcoholic-extract-of-echinacea-purpurea-in-combination-with-meglumine-antimoniate-on-treatment-of-leishmania-major-induced-cutaneous-leishmaniasis-in-balb-c-mice
#7
Bahador Sarkari, Mobin Mohseni, Mahmoud Reza Moein, Reza Shahriarirad, Qasem Asgari
CONTEXT: Progressive resistance of Leishmania parasite to available drugs including, meglumine antimoniate, has been reported from various regions of the world, especially Iran. AIMS: This study was conducted to evaluate the effect of hydroalcoholic extract of Echinacea purpurea in a combination therapy with glucantime in the treatment of cutaneous leishmaniasis caused by Leishmania major. MATERIALS AND METHODS: Hydroalcoholic extract of E...
January 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28239885/cutaneous-leishmaniasis-associated-with-anti-tumour-necrosis-factor-%C3%AE-drugs-an-emerging-disease
#8
J Marcoval, R M Penín, N Sabé, F Valentí-Medina, M Bonfill-Ortí, L Martínez-Molina
Leishmaniasis is endemic in several geographic areas of the world. In each of these areas, particular species of Leishmania with differing aggressiveness to humans predominate. In the European Mediterranean basin, cutaneous leishmaniasis usually presents with discrete, self-healing skin lesions. Although it is known that tumour necrosis factor (TNF) inhibitors may increase the risk of developing infections such as tuberculosis, there is scarce literature on Leishmania infections in patients treated with these drugs...
February 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28239875/american-cutaneous-leishmaniasis-in-situ-immune-response-of-patients-with-recent-and-late-lesions
#9
Aparecida Helena Souza Gomes, Roosecelis Brasil Martines, Cristina Takami Kanamura, Maria Lourdes Peris Barbo, Silvia D'Andretta Iglezias, José Angelo Lauletta Lindoso, Vera Lucia Pereira-Chioccola
TNF-α, IFN-γ, IL-10, IL-17, CD68, and CD57 were evaluated in biopsies of patients with American cutaneous leishmaniasis living in Sorocaba, Brazil. The analyses were performed considering the time of lesions from 23 patients with recent lesions (Group I) and 19 patients with late lesions (Group II). All patients were infected with Leishmania (Viannia) braziliensis. Immunostaining cells for CD68, CD57, TNF- α, IFN-γ, IL-10, and IL-17 were performed by immunohistochemistry. Except for CD68 and IL-17, the distribution of in situ for CD57, IL-10, TNF-α and IFN-γ showed that patients with recent lesions expressed higher levels than those with late lesions...
February 26, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28222637/genotyping-leishmania-promastigotes-isolated-from-patients-with-cutaneous-leishmaniasis-in-south-eastern-turkey
#10
Fahriye Ekşi, Orhan Özgöztaşı, Tekin Karslıgil, Mustafa Sağlam
Objective Cutaneous leishmaniasis (CL) is a significant disease in south-eastern Anatolia because it is prevalent among Syrian refugees. We identified the causative Leishmania species in CL patients using molecular methods. Methods Novy-MacNeal-Nicolle medium was inoculated with aspirated fluid from suspected CL lesions and tested for amastigotes with Giemsa staining. PCR amplified the internal transcribed spacer 1 (ITS1) of the Leishmania genome in cultures containing Leishmania promastigotes from 100 patients, which were genotyped with a restriction fragment length polymorphism (RFLP) analysis...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28219639/leishmania-l-amazonensis-induces-hyperalgesia-in-balb-c-mice-contribution-of-endogenous-spinal-cord-tnf%C3%AE-and-nf%C3%AE%C2%BAb-activation
#11
Sergio M Borghi, Victor Fattori, Kenji W Ruiz-Miyazawa, Milena M Miranda-Sapla, Rúbia Casagrande, Phileno Pinge-Filho, Wander R Pavanelli, Waldiceu A Verri
Cutaneous leishmaniasis (CL) is the most common form of the leishmaniasis in humans. Ulcerative painless skin lesions are predominant clinical features of CL. Wider data indicate pain accompanies human leishmaniasis, out with areas of painless ulcerative lesions per se. In rodents, Leishmania (L.) major infection induces nociceptive behaviors that correlate with peripheral cytokine levels. However, the role of the spinal cord in pain processing after Leishmania infection has not been investigated. Balb/c mice received intraplantar (i...
February 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28192528/cd8-t-cell-cytotoxicity-mediates-pathology-in-the-skin-by-inflammasome-activation-and-il-1%C3%AE-production
#12
Fernanda O Novais, Augusto M Carvalho, Megan L Clark, Lucas P Carvalho, Daniel P Beiting, Igor E Brodsky, Edgar M Carvalho, Phillip Scott
Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1β release as a detrimental consequence of CD8+ T cell-mediated cytotoxicity, ultimately resulting in chronic inflammation...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28177049/n-acetyl-cysteine-inhibits-liver-oxidative-stress-markers-in-balb-c-mice-infected-with-leishmania-amazonensis
#13
Juciano Gasparotto, Alice Kunzler, Mario Roberto Senger, Celeste da Silva Freitas de Souza, Salvatore Giovanni de Simone, Rafael Calixto Bortolin, Nauana Somensi, Felipe Dal-Pizzol, José Claudio Fonseca Moreira, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese, Floriano Paes Silva, Daniel Pens Gelain
BACKGROUND: Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES: To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on these parameters. METHODS: Four months after infection, oxidative and inflammatory parameters of liver, kidneys, spleen, heart and lungs from BALB/c mice were assessed...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28167598/in-vitro-sensitivity-of-cutaneous-leishmania-promastigote-isolates-circulating-in-french-guiana-to-a-set-of-drugs
#14
Marine Ginouvès, Stéphane Simon, Mathieu Nacher, Magalie Demar, Bernard Carme, Pierre Couppié, Ghislaine Prévot
Anti-leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of Leishmania isolates circulating in French Guiana and to highlight potential in vitro pentamidine-resistant isolates. This sensitivity study was conducted on 36 patient-promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit-8 viability test. The IC50 values obtained were heterogeneous...
February 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28150041/evaluation-of-a-hypothetical-protein-for-serodiagnosis-and-as-a-potential-marker-for-post-treatment-serological-evaluation-of-tegumentary-leishmaniasis-patients
#15
Mariana Pedrosa Lima, Lourena Emanuele Costa, Mariana Costa Duarte, Daniel Menezes-Souza, Beatriz Cristina Silveira Salles, Thaís Teodoro de Oliveira Santos, Fernanda Fonseca Ramos, Miguel Angel Chávez-Fumagalli, Amanda Christine Silva Kursancew, Roberta Passamani Ambrósio, Bruno Mendes Roatt, Ricardo Andrez Machado-de-Ávila, Denise Utsch Gonçalves, Eduardo Antonio Ferraz Coelho
The serodiagnosis for tegumentary leishmaniasis (TL) presents problems related to the sensitivity and/or specificity of the tests. In the present study, an enzyme-linked immunosorbent assay (ELISA) technique was used to evaluate the performance from a Leishmania braziliensis hypothetical protein, LbHyM, in an attempt to compare its serological reactivity with a soluble Leishmania antigenic preparation (SLA) for the serodiagnosis of cutaneous (CL) and mucosal (ML) leishmaniasis. LbHyM was predicted to be a kinesin-like protein by bioinformatics tools...
February 1, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28137819/use-of-optical-imaging-technology-in-the-validation-of-a-new-rapid-cost-effective-drug-screen-as-part-of-a-tiered-in-vivo-screening-paradigm-for-development-of-drugs-to-treat-cutaneous-leishmaniasis
#16
Diana Caridha, Sandi Parriot, Thomas H Hudson, Thierry Lang, Franklyn Ngundam, Susan Leed, Jenell Sena, Michael Harris, Michael O'Neil, Richard Sciotti, Lisa Read, Herve Lecoeur, Mark Hickman, Max Grogl
In any drug discovery and development effort, reduction in the lead optimization cycle is critical to decrease the time to license and reduce cost. In addition, ethical guidelines call for more ethical use of animals to minimize the number of animals used and decrease their suffering. Therefore, any cutaneous Leishmaniasis drug development effort requires multiple tiers of in vivo testing that start with higher-throughput efficacy assessments and progress to lower-throughput models with the most clinical relevance...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28131912/healing-leishmaniasis-in-amazonia-review-of-ethnomedicinal-concepts-and-pharmaco-chemical-analysis-of-traditional-treatments-to-inspire-modern-phytotherapies
#17
REVIEW
Guillaume Odonne, Emeline Houël, Geneviève Bourdy, Didier Stien
ETHNOPHARMACOLOGICAL RELEVANCE: Cutaneous/mucocutaneous leishmaniasis are neglected tropical diseases occurring in all intertropical regions of the world. Amazonian populations developed an abundant knowledge related to the disease and its remedies. Therefore, we undertook to review traditional antileishmanial plants in Amazonia, and developed new tools to analyze this somewhat dispersed information. MATERIAL AND METHODS: A review of the literature concerning traditional remedies against cutaneous/mucocutaneous leishmaniasis in the Amazon was conducted, and the obtained data used for the calculation of distribution indexes designed to highlight the most relevant uses in Amazonia...
January 25, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28127360/species-identification-and-molecular-typing-of-leishmania-spp-using-targeting-hsp70-gene-in-suspected-patients-of-cutaneous-leishmaniasis-from-sistan-and-baluchestan-province-southeast-iran
#18
Hadi Mirahmadi, Alireza Salimi Khorashad, Alireza Sohrabnahad, Peyman Heydarian, Negar Bizhani
BACKGROUND: Leishmaniasis is a sand fly-borne disease caused by the protozoan parasites belonging to the genus Leishmania. Because of the preventing and controlling methods, clinical course, prognosis and choice of treatment are differing from species; differentiation of species is critical. The present study was aimed to detect the parasite species using the PCR-RFLP method. METHODS: A total of 130 Giemsa-Stained slides from suspected Cutaneous leishmaniasis (CL) patients were examined under a light microscope at ×1000...
October 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28124961/-investigation-of-cutaneous-leishmaniasis-by-active-screening-in-primary-schools-in-sanliurfa-turkey
#19
Nebiye Yentür Doni, Gülcan Gürses, Reşat Dikme, Zeynep Şimşek, Mehmet Muratoğlu, Fadile Yıldız Zeyrek, Yavuz Yeşilova
Cutaneous leishmaniasis (CL) is endemic in Sanliurfa, a province located at southestern part of Turkey. The aims of this study were to determine CL cases among children aged 7-15 years attending primary schools and evaluate the demographical and clinical characteristics by active screening method. In our study, a total of 163.464 children attending to 123 primary schools have been evaluated in terms of CL prevalence between 2010 to 2012 period. Accordingly, 67.585, 72.279 and 23.600 students studying in 74, 37 and 12 primary schools were actively screened, respectively...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28122496/lip-leishmaniasis-a-case-series-with-molecular-identification-and-literature-review
#20
Iraj Mohammadpour, Mohammad Hossein Motazedian, Farhad Handjani, Gholam Reza Hatam
BACKGROUND: Mucocutaneous leishmaniasis (MCL), a protozoan infectious disease, is very rare in Iran despite the endemicity of both cutaneous and visceral forms. It is transmitted by the Phlebotomus sand fly. The lip is considered one of the extraordinary sites. Lesions usually initiate with erythematous papules, slowly enlarges and then it ulcerates. The diagnosis of MCL encompasses epidemiological, clinical and laboratory aspects. Usually, the combination of some of these elements is necessary for the final diagnosis...
January 25, 2017: BMC Infectious Diseases
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