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cutanous leishmaniasis treatment

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https://www.readbyqxmd.com/read/28446739/suspected-cutaneous-leishmaniasis-in-a-sample-of-westerns-sicily-residents-what-correlation-with-occupation
#1
Maria Gabriella Verso, Fabrizio Vitale, Germano Castelli, Federica Bruno, Antonella Migliazzo, Maria Rita Bongiorno, Fiorella Santi, Giuseppe Pistone, Emanuele Amodio, Diego Picciotto
BACKGROUND: Leishmaniasis is a widespread infectious disease, but there is not much information about its prevalence in high risk occupational categories. OBJECTIVES: The aim of this study is to assess the prevalence of Leishmania immunological positivity in human skin tissues collected from subjects living in Western Sicily, with suspected cutaneous Leishmania infection, in order to explore the risk possibly related to occupation. METHODS: 318 consecutive subjects (M/F ratio=1...
April 21, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28433563/aryl-thiosemicarbazones-in-vitro-and-immunomodulatory-activities-against-l-amazonensis
#2
Aline Caroline da Silva, Thiago André Ramos Dos Santos, Isis Viviane Bezerra da Silva, Marcos Victor Gregório de Oliveira, Diogo Rodrigo Magalhães Moreira, Ana Cristina Lima Leite, Valéria Rêgo Alves Pereira
Leishmaniasis is an infection caused by different species of Leishmania genus. Currently, there is no vaccine available for Leishmania infections in humans and conventional treatments are limited due to side effects. Therefore, the development of new antileishmanial drugs is an urgent need. In present study, we evaluated the cytotoxicity in host cells, leishmanicidal activity and immunomodulatory potential of seven aryl thiosemicarbazones. Host cell cytotoxicity was determined in peritoneal macrophages of BALB/c mouse, antiparasitic activity was determined against promastigotes and amastigotes of WHOM/00LTB 0016 strain of L...
April 19, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28423087/epidemiological-aspects-of-american-cutaneous-leishmaniasis-acl-in-an-endemic-area-of-forest-extractivist-culture-in-western-brazilian-amazonia
#3
Andreia Fernandes Brilhante, Leonardo Augusto Kohatsu Melchior, Vânia Lúcia Brandão Nunes, Cristiane de Oliveira Cardoso, Eunice Aparecida Bianchi Galati
The study sought to analyze clinical and epidemiological aspects of cutaneous leishmaniasis (CL) in Xapuri, Acre, Brazil. Data from 2008 to 2014 registered in the notification records of the disease of the Information System of the Complaints of Notification (SINAN), and the data of the Information Department of the Unified Health System (DATASUS) available from 2007 to 2013 were used and analyzed in the light of the statistics of the temporal series by the Prais-Winsten method and chi-squared test. A total of 906 cases were registered with 60...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28385151/psychosocial-impact-of-scars-due-to-cutaneous-leishmaniasis-on-high-school-students-in-errachidia-province-morocco
#4
Issam Bennis, Séverine Thys, Hind Filali, Vincent De Brouwere, Hamid Sahibi, Marleen Boelaert
BACKGROUND: In Morocco, cutaneous leishmaniasis (CL) is usually known to be a slowly healing localized skin disease, but in some cases, it can lead to mutilating scars. The outbreak of CL due to Leishmania major in the Errachidia province in southeastern Morocco between 2008 and 2010 left many adolescents with permanent scar tissue on the face or other exposed body parts. We studied the psychosocial impact of CL on these young people. METHODS: In 2015 we conducted a cross-sectional survey among high-school students living in boarding schools in two CL-endemic areas of Errachidia: Rissani and Tinejdad...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28384261/cost-effectiveness-of-meglumine-antimoniate-versus-miltefosine-caregiver-dot-for-the-treatment-of-pediatric-cutaneous-leishmaniasis
#5
Brandon A Berger, Alexandra Cossio, Nancy Gore Saravia, Maria Del Mar Castro, Sergio Prada, Allison H Bartlett, Mai T Pho
BACKGROUND: Oral miltefosine has been shown to be non-inferior to first-line, injectable meglumine antimoniate (MA) for the treatment of cutaneous leishmaniasis (CL) in children. Miltefosine may be administered via in-home caregiver Directly Observed Therapy (cDOT), while patients must travel to clinics to receive MA. We performed a cost-effectiveness analysis comparing miltefosine by cDOT versus MA for pediatric CL in southwest Colombia. METHODOLOGY/PRINCIPLE FINDINGS: We developed a Monte Carlo model comparing the cost-per-cure of miltefosine by cDOT compared to MA from patient, government payer, and societal perspectives (societal = sum of patient and government payer perspective costs)...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28380117/reactivation-of-cutaneous-and-mucocutaneous-tegumentary-leishmaniasis-in-rheumatoid-arthritis-patients-an-emerging-problem
#6
Regina Maia de Souza, Heitor Franco de Andrade, Maria Irma Seixas Duarte, Lucia Maria Almeida Braz, Armando de Oliveira Schubach, Fátima Conceição Silva, Valdir Sabbaga Amato
Rheumatoid arthritis (RA) is a chronic condition that is frequent in patients living in tropical areas exposed to leishmaniasis. RA therapy involves immunosuppressant drugs such as methotrexate (MTX), monoclonal antibodies (mAbs) and prednisone. We report an unusual presentation of cutaneous (CL) or mucocutaneous leishmaniasis (ML) in RA patients from an endemic area of leishmaniasis. A 51-year-old woman noted a cutaneous ulcer on her left ankle during MTX and prednisone RA therapy. Initially diagnosed as a venous stasis ulcer, the aspirate of the injury revealed the presence of Leishmania DNA...
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28379954/risk-factors-for-therapeutic-failure-to-meglumine-antimoniate-and-miltefosine-in-adults-and-children-with-cutaneous-leishmaniasis-in-colombia-a-cohort-study
#7
Maria Del Mar Castro, Alexandra Cossio, Carlos Velasco, Lyda Osorio
INTRODUCTION: Reports of therapeutic failure to meglumine antimoniate (MA) and miltefosine in cutaneous leishmaniasis (CL) varies between species, populations and geographic regions. This study aimed to determine the clinical, drug-related factors, and Leishmania species associated with treatment failure in children and adults with cutaneous leishmaniasis. METHODS: A cohort study was performed with children (2-12 years old) and adults (18-65 years old) with CL, who have participated in clinical studies at CIDEIM Cali, Tumaco and Chaparral...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28367792/safety-and-efficacy-of-current-alternatives-in-the-topical-treatment-of-cutaneous-leishmaniasis-a-systematic-review
#8
Priscila Wolf Nassif, Tatiane França Perles DE Mello, Taísa Rocha Navasconi, Camila Alves Mota, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira
Studies of topical treatments for leishmaniasis were systematically reviewed, to evaluate the therapeutic efficacy, safety and any adverse effects of these treatments. The papers identified in the databases PubMed and Web of Knowledge involved eight studies with a total of 1744 patients. The majority of trials was from Iran (4/8), covered a period of 8 years (2003-2011), and included patients 4-85 years of age. The most frequent Leishmania species in the studies were L. tropica (4/8) and L. major (2/8). The treatments administered were thermotherapy, paromomycin and combinations, CO2 laser, 5-aminolevulinic acid hydrochloride (10%) plus visible red light (633 nm) and cryotherapy...
April 3, 2017: Parasitology
https://www.readbyqxmd.com/read/28349020/treatment-outcome-of-the-drug-resistant-zoonotic-cutaneous-leishmaniasis-by-glucantime
#9
Simindokht Soleimanifard, Reza Arjmand, Sedighe Saberi, Mansoor Salehi, Seyed Hossain Hejazi
BACKGROUND: Resistance of Leishmania species to antimonial drugs has increased. Hence, in the present study Leishmania major isolates were collected from patients with resistance phenotype and the presence/absence of resistance to Glucantime was investigated. MATERIALS AND METHODS: Samples were taken from 10 cutaneous leishmaniasis (CL) patients who had not responded to chemotherapy with Glucantime. Nested polymerase chain reaction (PCR) was performed to identify the isolated species...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28335752/development-of-a-rapid-loop-mediated-isothermal-amplification-assay-for-diagnosis-and-assessment-of-cure-of-leishmania-infection
#10
Sandeep Verma, Ruchi Singh, Vanila Sharma, Ram Avtar Bumb, Narendra Singh Negi, V Ramesh, Poonam Salotra
BACKGROUND: Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel. A robust, rapid and cost effective diagnostic test is warranted for on-time diagnosis and field application. METHODS: We have developed a loop mediated isothermal amplification (LAMP) assay with primers (n = 6) based on Leishmania donovani kDNA for detection of Leishmania infection, using a closed tube to prevent cross-contamination...
March 23, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28327802/in-vitro-and-in-vivo-antileishmanial-activity-of-artemisia-annua-l-leaf-powder-and-its-potential-usefulness-in-the-treatment-of-uncomplicated-cutaneous-leishmaniasis-in-humans
#11
Luz Estella Mesa, Daniel Vasquez, Pierre Lutgen, Iván Darío Vélez, Adriana María Restrepo, Isabel Ortiz, Sara María Robledo
INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of various diseases in 80% of the global population, the validation of these products is essential. Gelatin capsules containing dried Artemisia annua leaf powder were recently developed as a new herbal formulation (totum) for the oral treatment of malaria and other parasitic diseases...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28281913/rapidly-progressing-facial-leishmaniasis-effective-treatment-with-liposomal-amphotericin-b-and-a-review-of-the-management-of-old-world-cutaneous-leishmaniasis
#12
Shamim Islam
Cutaneous leishmaniasis (CL), a common condition in many parts of the world, is being increasingly encountered in non-endemic countries secondary to immigration. The clinical manifestations and course can vary substantially, with appropriate management ranging from observation for self-healing lesions to urgent treatment to prevent damaging anatomical and cosmetic sequelae. While there are now several effective medications, optimal therapy is not well defined, and decision-making can be challenged by the location of lesions and various drug issues, including availability, mode of delivery and adverse effects...
March 10, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28276641/cost-effectiveness-analysis-of-thermotherapy-versus-pentavalent-antimonials-for-the-treatment-of-cutaneous-leishmaniasis
#13
Jaiberth Antonio Cardona-Arias, Liliana López-Carvajal, Mery Patricia Tamayo Plata, Iván Darío-Vélez
OBJECTIVE: The treatment of cutaneous leishmaniasis is toxic, has contraindications and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. METHODS: Effectiveness was the proportion of healing, and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing were conducted...
February 5, 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28274283/topical-tamoxifen-in-the-therapy-of-cutaneous-leishmaniasis
#14
Cristiana T Trinconi, Juliana Q Reimão, Vivian I Bonano, Caroline R Espada, Danilo C Miguel, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana
The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial combinations in an experimental model of cutaneous leishmaniasis. BALB/c mice infected with a luciferase expressing line of Leishmania amazonensis were treated with topical tamoxifen in two different formulations (ethanol or oil-free cream) as monotherapy or in co-administration with pentavalent antimonial. Treatment efficacy was evaluated by lesion size and parasite burden, quantified through luminescence, at the end of treatment and 4 weeks later...
March 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28263719/mechanism-of-ascaridole-activation-in-leishmania
#15
Gerald Geroldinger, Matthias Tonner, Hubert Hettegger, Markus Bacher, Lianet Monzote, Martin Walter, Katrin Staniek, Thomas Rosenau, Lars Gille
Endoperoxides (EP) are an emerging class of drugs which have potential in antiparasitic therapy, but also in other fields. For malaria therapy the EP artemisinin (Art) and its derivatives are successfully used. We have shown in the past that the EP ascaridole (Asc) is useful for the treatment of cutaneous leishmaniasis in a mouse model. Biomimetic experiments suggested that these drugs need activation in the respective target pathogens to exert their function. In spite of this idea, direct activation of EP to radicals inside cells has never been demonstrated...
March 2, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28251109/effect-of-hydroalcoholic-extract-of-echinacea-purpurea-in-combination-with-meglumine-antimoniate-on-treatment-of-leishmania-major-induced-cutaneous-leishmaniasis-in-balb-c-mice
#16
Bahador Sarkari, Mobin Mohseni, Mahmoud Reza Moein, Reza Shahriarirad, Qasem Asgari
CONTEXT: Progressive resistance of Leishmania parasite to available drugs including, meglumine antimoniate, has been reported from various regions of the world, especially Iran. AIMS: This study was conducted to evaluate the effect of hydroalcoholic extract of Echinacea purpurea in a combination therapy with glucantime in the treatment of cutaneous leishmaniasis caused by Leishmania major. MATERIALS AND METHODS: Hydroalcoholic extract of E...
January 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28239885/cutaneous-leishmaniasis-associated-with-anti-tumour-necrosis-factor-%C3%AE-drugs-an-emerging-disease
#17
J Marcoval, R M Penín, N Sabé, F Valentí-Medina, M Bonfill-Ortí, L Martínez-Molina
Leishmaniasis is endemic in several geographic areas of the world. In each of these areas, particular species of Leishmania with differing aggressiveness to humans predominate. In the European Mediterranean basin, cutaneous leishmaniasis usually presents with discrete, self-healing skin lesions. Although it is known that tumour necrosis factor (TNF) inhibitors may increase the risk of developing infections such as tuberculosis, there is scarce literature on Leishmania infections in patients treated with these drugs...
February 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28239875/american-cutaneous-leishmaniasis-in-situ-immune-response-of-patients-with-recent-and-late-lesions
#18
A H S Gomes, R B Martines, C T Kanamura, M L P Barbo, S D Iglezias, J A Lauletta Lindoso, V L Pereira-Chioccola
TNF-α, IFN-γ, IL-10, IL-17, CD68 and CD57 were evaluated in biopsies of patients with American cutaneous leishmaniasis living in Sorocaba, Brazil. The analyses were performed considering the time of lesions from 23 patients with recent lesions (Group I) and 19 patients with late lesions (Group II). All patients were infected with Leishmania (Viannia) braziliensis. Immunostaining cells for CD68, CD57, TNF- α, IFN-γ, IL-10 and IL-17 were performed by immunohistochemistry. Except for CD68 and IL-17, the distribution of in situ for CD57, IL-10, TNF-α and IFN-γ showed that patients with recent lesions expressed higher levels than those with late lesions...
February 26, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28222637/genotyping-leishmania-promastigotes-isolated-from-patients-with-cutaneous-leishmaniasis-in-south-eastern-turkey
#19
Fahriye Ekşi, Orhan Özgöztaşı, Tekin Karslıgil, Mustafa Sağlam
Objective Cutaneous leishmaniasis (CL) is a significant disease in south-eastern Anatolia because it is prevalent among Syrian refugees. We identified the causative Leishmania species in CL patients using molecular methods. Methods Novy-MacNeal-Nicolle medium was inoculated with aspirated fluid from suspected CL lesions and tested for amastigotes with Giemsa staining. PCR amplified the internal transcribed spacer 1 (ITS1) of the Leishmania genome in cultures containing Leishmania promastigotes from 100 patients, which were genotyped with a restriction fragment length polymorphism (RFLP) analysis...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28219639/leishmania-l-amazonensis-induces-hyperalgesia-in-balb-c-mice-contribution-of-endogenous-spinal-cord-tnf%C3%AE-and-nf%C3%AE%C2%BAb-activation
#20
Sergio M Borghi, Victor Fattori, Kenji W Ruiz-Miyazawa, Milena M Miranda-Sapla, Rúbia Casagrande, Phileno Pinge-Filho, Wander R Pavanelli, Waldiceu A Verri
Cutaneous leishmaniasis (CL) is the most common form of the leishmaniasis in humans. Ulcerative painless skin lesions are predominant clinical features of CL. Wider data indicate pain accompanies human leishmaniasis, out with areas of painless ulcerative lesions per se. In rodents, Leishmania (L.) major infection induces nociceptive behaviors that correlate with peripheral cytokine levels. However, the role of the spinal cord in pain processing after Leishmania infection has not been investigated. Balb/c mice received intraplantar (i...
April 25, 2017: Chemico-biological Interactions
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