keyword
MENU ▼
Read by QxMD icon Read
search

cutanous leishmaniasis treatment

keyword
https://www.readbyqxmd.com/read/28641584/crotoxin-stimulates-an-m1-activation-profile-in-murine-macrophages-during-leishmania-amazonensis-infection
#1
L H S Farias, A P D Rodrigues, E C Coêlho, M F Santos, S C Sampaio, E O Silva
American tegumentary leishmaniasis is caused by different species of Leishmania. This protozoan employs several mechanisms to subvert the microbicidal activity of macrophages and, given the limited efficacy of current therapies, the development of alternative treatments is essential. Animal venoms are known to exhibit a variety of pharmacological activities, including antiparasitic effects. Crotoxin (CTX) is the main component of Crotalus durissus terrificus venom, and it has several biological effects. Nevertheless, there is no report of CTX activity during macrophage - Leishmania interactions...
June 23, 2017: Parasitology
https://www.readbyqxmd.com/read/28630867/potential-challenges-of-controlling-leishmaniasis-in-sri-lanka-at-a-disease-outbreak
#2
REVIEW
Tharaka Wijerathna, Nayana Gunathilaka, Kithsiri Gunawardana, Wasana Rodrigo
The present works reviewed the existing information on leishmaniasis in Sri Lanka and in other countries, focusing on challenges of controlling leishmaniasis in the country, in an outbreak. Evidence from recent studies suggests that there is a possibility of a leishmaniasis outbreak in Sri Lanka in the near future. Difficulty of early diagnosis due to lack of awareness and unavailability or inadequacy of sensitive tests are two of the main challenges for effective case management. Furthermore, the absence of a proper drug for treatment and lack of knowledge about vector biology, distribution, taxonomy and bionomics, and reservoir hosts make the problem serious...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28630182/study-of-biodistribution-and-in-vivo-anti-leishmanial-activity-of-a-distigmasterylhemisuccinoyl-glycero-phosphocholine-liposome-intercalated-amphotericin-b
#3
Maryam Iman, Zhaohua Huang, Seyedeh Hoda Alavizadeh, Francis C Szoka, Mahmoud R Jaafari
Distigmasterylhemisuccinoyl-sn-glycero-3- phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Our previous study revealed that a liposome-intercalated Amphotericin B prepared from DSHemsPC (DSHemsPC-Lip-AmB) possess excellent colloidal properties and in vitro antifungal and anti-leishmanial activity similar to AmBisome™. The aim of this study was to determine biodistribution and evaluate the anti-leishmanial effects of DSHemsPC-Lip-AmB in Leishmania major-infected BALB/c mice...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28616411/identification-of-etiologic-agents-of-cutaneous-leishmaniasis-in-palpebral-position-followed-by-effective-therapy
#4
Sedigheh Saberi, Reza Arjmand, Ali Khamesipour, Mohammad Ali Nilforoushzadeh, Shaghayegh Sayareh, Seyed Hossein Hejazi
CONTEXT: Cutaneous Leishmaniasis (CL) is a self-healing lesion but prevention of complications and involvement of vital organs such as palpebra requires proper treatment. AIMS: The main objectives were to detect agents of CL in palpebral region and estimate the proportion of palpebral lesion also possible complications among CL patients in a zoonotic CL endemic area. SETTINGS AND DESIGN: The study was performed from April 2012 to March 2013 in a total of 1613 CL suspected patients by interview and physically exam...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28607026/efficacy-of-a-paromomycin-plus-chloroquine-combination-therapy-in-experimental-cutaneous-leishmaniasis
#5
Gert-Jan Wijnant, Katrien Van Bocxlaer, Vanessa Yardley, Sudaxshina Murdan, Simon Croft
The 4-aminoquinoline chloroquine (CQ) is clinically used in combination with doxycycline to cure chronic Q-fever, as it enhances the activity of the antibiotic against the causative Coxiella burnetii bacteria residing within macrophage phagolysosomes. As there is a similar cellular host-pathogen biology for Leishmania parasites, this study aimed to determine whether such an approach could be also the basis for a new, improved treatment for cutaneous leishmaniasis (CL). We have evaluated the in vitro and in vivo activity of combinations of CQ with standard drugs paromomycin (PM), miltefosine and amphotericin B against Leishmania major and Leishmania mexicana In 72-hour intracellular anti-leishmanial assays, outcomes were variable for different drugs...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28602835/topical-treatment-with-nanoliposomal-amphotericin-b-reduces-early-lesion-growth-but-fails-to-induce-cure-in-an-experimental-model-of-cutaneous-leishmaniasis-caused-by-leishmania-mexicana
#6
Sanjay Varikuti, Steve Oghumu, Noushin Saljoughian, Marissa S Pioso, Bren E Sedmak, Ali Khamesipour, Abhay R Satoskar
Leishmania mexicana infection causes localized skin lesions that can lead to tissue damage and permanent disfigurement if not resolved. Currently, recommended treatments include intravenous administration of Amphotericin B, which is undesirable due to the associated cost and patient burden related to receiving regular injections. In this study, we evaluated the effect of topical treatment with a nanoliposomal formulation of Amphotericin B that is penetrable to the skin (SinaAmphoLeish 0.4%) in mice infected with L...
June 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28597089/vosalophen-a-vanadium-complex-with-a-stilbene-derivative-induction-of-apoptosis-autophagy-and-efficiency-in-experimental-cutaneous-leishmaniasis
#7
Patrícia de A Machado, Jessica O F Morais, Gustavo S G Carvalho, Wallace P Lima, Gilson C Macedo, Elizandra A Britta, Celso V Nakamura, Adilson D da Silva, Alexandre Cuin, Elaine S Coimbra
In our previous work, we demonstrated the promising in vitro effect of VOSalophen, a vanadium complex with a stilbene derivative, against Leishmania amazonensis. Its antileishmanial activity has been associated with oxidative stress in L. amazonensis promastigotes and L. amazonensis-infected macrophages. In the present study, the mechanism involved in the death of parasites after treatment with VOSalophen, as well as in vivo effect in the murine model cutaneous leishmaniasis, has been investigated. Promastigotes of L...
June 8, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28591265/disseminated-cutaneous-leishmaniasis-caused-by-leishmania-braziliensis-in-southern-brazil
#8
Norberto Assis Membrive, Flávio Jun Kazuma, Thaís Gomes Verzignassi Silveira, Jorge Juarez Vieira Teixeira, Kárin Rosi Reinhold-Castro, Ueslei Teodoro
The authors report a case of disseminated cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis, in a 55 years old patient with 1,119 lesions distributed throughout the body. The patient resides in Sabáudia municipality, North of Paraná State, Southern Brazil, where there was no previous report of this form of leishmaniasis. Treatment with meglumine antimoniate was successful, although the diagnosis was made only five months later.
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28583224/anti-parasitic-effect-of-the-diuretic-and-na-atpase-inhibitor-furosemide-in-cutaneous-leishmaniasis
#9
N Arruda-Costa, D Escrivani, E E Almeida-Amaral, J R Meyer-Fernandes, B Rossi-Bergmann
Leishmania amazonensis promastigotes are known to express furosemide (Lasix®)-sensitive P-type membrane Na+-ATPase. In the present study, furosemide activity was studied in intracellular amastigotes and infected BALB/c mice to investigate its efficacy in cutaneous leishmaniasis (CL). Intracellular parasites, but not macrophages, were found to be sensitive to killing by furosemide (IC50 = 87 µ m vs CC50 ≫ 1000 µ m, respectively). Although furosemide did not induce nitric oxide production or intracellular pH changes in infected macrophages, it led to a significant reactive oxygen species (ROS) burst...
June 6, 2017: Parasitology
https://www.readbyqxmd.com/read/28573235/in-vivo-and-in-vitro-antileishmanial-effects-of-methanolic-extract-from-bark-of-bursera-aptera
#10
O J Nieto-Yañez, A A Resendiz-Albor, P A Ruiz-Hurtado, N Rivera-Yañez, M Rodriguez-Canales, M Rodriguez-Sosa, I Juarez-Avelar, M G Rodriguez-Lopez, M M Canales-Martinez, M A Rodriguez-Monroy
BACKGROUND: Cutaneous leishmaniasis lacks effective and well-tolerated treatments. The current therapies mainly rely on antimonial drugs that are inadequate because of their poor efficacy. Traditional medicine offers a complementary alternative for the treatment of various diseases. Additionally, several plants have shown success as anti-leishmanial agents. Therefore, we sought to evaluate the in vitro and in vivo activity of MEBA against Leishmania mexicana. MATERIALS AND METHODS: Methanolic extract of B...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28562769/intralesional-treatment-with-meglumine-antimoniate-in-three-patients-with-new-world-cutaneous-leishmaniasis-and-large-periarticular-lesions-with-comorbidities
#11
Maria Inês Fernandes Pimentel, Érica de Camargo Ferreira E Vasconcellos, Carla de Oliveira Ribeiro, Marcelo Rosandiski Lyra, Mauricio Naoto Saheki, Mariza de Matos Salgueiro, Liliane de Fátima Antonio, Armando de Oliveira Schubach
Although New World cutaneous leishmaniasis is not itself a life-threatening disease, its treatment with systemic antimonials can cause toxicity that can be dangerous to some patients. Intralesional meglumine antimoniate provides a viable, less toxic alternative. Herein, we describe an alternative treatment with subcutaneous intralesional injections of meglumine antimoniate into large periarticular lesions of three patients with cutaneous leishmaniasis and comorbidities. This treatment was safe, successful, and well tolerated...
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28562730/-socio-epidemiological-and-cultural-aspects-of-cutaneous-leishmaniasis-conceptions-attitudes-and-practices-in-the-populations-of-tierralta-and-valencia-cordoba-colombia
#12
Sandra Yaneth Patiño-Londoño, Lina Marcela Salazar, Catalina Tovar Acero, Iván Darío Vélez Bernal
This article focuses on the conceptions, attitudes and practices of the inhabitants from four villages (veredas) in Tierralta and Valencia (Cordoba, Colombia), who have suffered from or are aware of the existence of cutaneous leishmaniasis. A mixed methodology was implemented based in a qualitative design using interviews and focus groups (n=45) and an epidemiological design which included applying the Montenegro test (n=251), uncovering suspected cases of cutaneous leishmaniasis in humans, (n=5) and applying epidemiological surveys (n=409)...
January 2017: Salud Colectiva
https://www.readbyqxmd.com/read/28558061/low-versus-high-dose-of-antimony-for-american-cutaneous-leishmaniasis-a-randomized-controlled-blind-non-inferiority-trial-in-rio-de-janeiro-brazil
#13
Mauricio Naoto Saheki, Marcelo Rosandiski Lyra, Sandro Javier Bedoya-Pacheco, Liliane de Fátima Antônio, Maria Inês Fernandes Pimentel, Mariza de Matos Salgueiro, Érica de Camargo Ferreira E Vasconcellos, Sonia Regina Lambert Passos, Ginelza Peres Lima Dos Santos, Madelon Novato Ribeiro, Aline Fagundes, Maria de Fátima Madeira, Eliame Mouta-Confort, Mauro Célio de Almeida Marzochi, Cláudia Maria Valete-Rosalino, Armando de Oliveira Schubach
BACKGROUND: Although high dose of antimony is the mainstay for treatment of American cutaneous leishmaniasis (ACL), ongoing major concerns remain over its toxicity. Whether or not low dose antimony regimens provide non-inferior effectiveness and lower toxicity has long been a question of dispute. METHODS: A single-blind, non-inferiority, randomized controlled trial was conducted comparing high dose with low dose of antimony in subjects with ACL treated at a referral center in Rio de Janeiro, an endemic area of Leishmania (Viannia) braziliensis transmission...
2017: PloS One
https://www.readbyqxmd.com/read/28538896/periungual-tegumentary-leishmaniasis-a-diagnostic-challenge
#14
Bruna Morassi Sasso, Ana Beatriz Barbosa Torino, Andréa Fernandes Eloy da Costa França, Paulo Eduardo Neves Ferreira Velho
Periungual and paronychia-like skin lesions can mimic various diseases, setting up a diagnostic challenge that invariably requires correlation with complementary tests. We report a case of an ulcerated tumor of the nailfold diagnosed as leishmaniasis. Although paronychia-like cutaneous leishmaniasis is a rare variant, its epidemiological relevance in Brazil should prompt dermatologists to include it as a plausible diagnosis thus leading to correct work up and treatment.
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28537873/leishmanial-dactylitis-an-unusual-clinical-presentation
#15
Nasrin Saki, Hamid Godarzi, Alireza Heiran
Cutaneous leishmaniasis (CL) is one of the most common endemic diseases in Iran. It has a diverse spectrum of clinical manifestations. Herein we present a woman with leishmanial dactylitis, which is a very rare clinical form of CL. Successful treatment consisted of parenteral pentavalent antimonials for two months. Leishmanial dactylitis can be easily misdiagnosed as bacterial or fungal infections, psoriasis, or even malignancies. Accordingly, it should be considered in the differential diagnosis of dactylitis in endemic areas and in travelers from endemic countries...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28530056/-cutaneous-leishmaniasis-in-israel-2016-an-update
#16
REVIEW
Michal Solomon, Eli Schwartz
Leishmaniasis is endemic in Israel and is increasing in its frequency. The pathogens that cause cutaneous leishmaniasis (CL) in Israel are Leishmania major (L. major) and Leishmania tropica (L. tropica). In recent years, there have been significant changes in the distribution of these species. L. major is endemic mainly in the Negev, Arava and the Beit She'an Valley. L. tropica is endemic in Tiberias, northern Sea of Galilee, Samaria and in the vicinity of Jerusalem such as at Kfar Adumim, Ma'ale Adumim and Anathoth (north-east of Jerusalem)...
October 2016: Harefuah
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#17
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
August 2017: Acta Tropica
https://www.readbyqxmd.com/read/28524774/cytotoxicity-and-anti-leishmania-amazonensis-activity-of-citrus-sinensis-leaf-extracts
#18
Andreza R Garcia, Ana Claudia F Amaral, Mariana M B Azevedo, Suzana Corte-Real, Rosana C Lopes, Celuta S Alviano, Anderson S Pinheiro, Alane B Vermelho, Igor A Rodrigues
CONTEXT: Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the Citrus genus possess antimicrobial activity. OBJECTIVE: This study evaluated the anti-L. amazonensis activity of Citrus sinensis (L.) Osbeck (Rutaceae) extracts. MATERIALS AND METHODS: Citrus sinensis dried leaves were subjected to maceration with hexane (CH), ethyl acetate (CEA), dichloromethane/ethanol (CD/Et - 1:1) or ethanol/water (CEt/W - 7:3)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28507113/efficacy-of-a-binuclear-cyclopalladated-compound-therapy-for-cutaneous-leishmaniasis-in-the-murine-model-of-infection-with-leishmania-amazonensis-and-its-inhibitory-effect-on-topoisomerase-1b
#19
Angela Maria Arenas Velásquez, Willian Campos Ribeiro, Vutey Venn, Silvia Castelli, Mariana Santoro, Renata Pires de Assis, Rodrigo Alves de Souza, Aline Rimoldi Ribeiro, Thaís Gaban Passalaqua, João Aristeu da Rosa, Amanda Martins Baviera, Antonio Eduardo Mauro, Alessandro Desideri, Elmo Eduardo Almeida-Amaral, Marcia A S Graminha
Leishmaniasis is a disease found throughout the (sub)tropical parts of the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance makes the discovery of new therapeutic alternatives urgent. Here we report the evaluation of a binuclear cyclopalladated complex containing Pd(II) and N,N' -dimethylbenzylamine (Hdmba) against Leishmania amazonensis...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28500815/oral-pentoxifylline-associated-with-pentavalent-antimony-a-randomized-trial-for-cutaneous-leishmaniasis
#20
Graça Brito, Mayra Dourado, Luiz Henrique Guimarães, Everson Meireles, Albert Schriefer, Edgar Marcelino de Carvalho, Paulo Roberto Lima Machado
AbstractCutaneous leishmaniasis (CL) by Leishmania braziliensis is associated with decreasing cure rates in Brazil. Standard treatment with pentavalent antimony (Sb(v)) cures only 50-60% of the cases. The immunopathogenesis of CL ulcer is associated with high interferon-γ and tumor necrosis factor (TNF) production. Pentoxifylline, a TNF inhibitor, has been successfully used in association with Sb(v) in mucosal and cutaneous leishmaniasis. This randomized, double-blind, and placebo-controlled trial aimed to evaluate the efficacy and safety of oral pentoxifylline plus Sb(v) versus placebo plus Sb(v) in patients with CL in Bahia, Brazil...
May 2017: American Journal of Tropical Medicine and Hygiene
keyword
keyword
94472
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"