keyword
MENU ▼
Read by QxMD icon Read
search

cutanous leishmaniasis treatment

keyword
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#1
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
May 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28524774/cytotoxicity-and-anti-leishmania-amazonensis-activity-of-citrus-sinensis-leaf-extracts
#2
Andreza R Garcia, Ana Claudia F Amaral, Mariana M B Azevedo, Suzana Corte-Real, Rosana C Lopes, Celuta S Alviano, Anderson S Pinheiro, Alane B Vermelho, Igor A Rodrigues
CONTEXT: Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the Citrus genus possess antimicrobial activity. OBJECTIVE: This study evaluated the anti-L. amazonensis activity of Citrus sinensis (L.) Osbeck (Rutaceae) extracts. MATERIALS AND METHODS: Citrus sinensis dried leaves were subjected to maceration with hexane (CH), ethyl acetate (CEA), dichloromethane/ethanol (CD/Et - 1:1) or ethanol/water (CEt/W - 7:3)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28507113/efficacy-of-a-binuclear-cyclopalladated-compound-therapy-for-cutaneous-leishmaniasis-in-the-murine-model-of-infection-with-leishmania-amazonensis-and-its-inhibitory-effect-on-topoisomerase-1b
#3
Angela Maria Arenas Velásquez, Willian Campos Ribeiro, Vutey Venn, Silvia Castelli, Mariana Santoro, Renata Pires de Assis, Rodrigo Alves de Souza, Aline Rimoldi Ribeiro, Thaís Gaban Passalaqua, João Aristeu da Rosa, Amanda Martins Baviera, Antonio Eduardo Mauro, Alessandro Desideri, Elmo Eduardo Almeida-Amaral, Marcia A S Graminha
Leishmaniasis is a disease found throughout the (sub)tropical parts of the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance makes the discovery of new therapeutic alternatives urgent. Here we report the evaluation of a binuclear cyclopalladated complex containing Pd(II) and N,N' -dimethylbenzylamine (Hdmba) against Leishmania amazonensis...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28500815/oral-pentoxifylline-associated-with-pentavalent-antimony-a-randomized-trial-for-cutaneous-leishmaniasis
#4
Graça Brito, Mayra Dourado, Luiz Henrique Guimarães, Everson Meireles, Albert Schriefer, Edgar Marcelino de Carvalho, Paulo Roberto Lima Machado
AbstractCutaneous leishmaniasis (CL) by Leishmania braziliensis is associated with decreasing cure rates in Brazil. Standard treatment with pentavalent antimony (Sb(v)) cures only 50-60% of the cases. The immunopathogenesis of CL ulcer is associated with high interferon-γ and tumor necrosis factor (TNF) production. Pentoxifylline, a TNF inhibitor, has been successfully used in association with Sb(v) in mucosal and cutaneous leishmaniasis. This randomized, double-blind, and placebo-controlled trial aimed to evaluate the efficacy and safety of oral pentoxifylline plus Sb(v) versus placebo plus Sb(v) in patients with CL in Bahia, Brazil...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28484104/design-of-treatments-for-cutaneous-and-visceral-leishmaniasis
#5
Simon Croft
No abstract text is available yet for this article.
2017: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/28483734/leishmaniasis-of-the-feet-sole-a-case-report
#6
Jamshid Ayatollahi, Ali Fattahi Bafghi, Seyed Hossein Shahcheraghi
Here we report the case of a patient with cutaneous leishmaniasis, who was referred to our clinic in Yazd, Iran. On examining the patient, who was a housekeeper, we found a small plaque in the palmoplantar region due to cutaneous leishmaniasis. She had not any history from an identical case in this patient. After treatment, the lesions improved.
March 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28474711/-case-report-disseminated-cutaneous-leishmaniasis-lcd
#7
Alexandra Mancheno-Valencia, Julia Cabezas-Arteaga, Ketty Sacoto-Aizaga, Roberto Arenas-Guzmáno
The World Health Organization (WHO) has classified leishmaniasis as an uncontrolled and emerging disease. In Ecuador, the only anecdotal cases of diffuse cutaneous leishmaniasis were recorded in 1994 and have not been formally published. This form can be differentiated from classical localized cutaneous leishmaniasis by the number of injuries, the clinical type of the main elementary lesions (papular and acneform), and a weak response to standard treatments. The case we report is a 34-year-old woman who presented with disseminated nodular lesions and ulcers of various sizes with erythematous edges and scars...
March 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28472733/in-vitro-inhibition-of-leishmania-attachment-to-sandfly-midguts-and-ll-5-cells-by-divalent-metal-chelators-anti-gp63-and-phosphoglycans
#8
Rodrigo Pedro Soares, Ellen Cristina Félix Altoé, Vítor Ennes-Vidal, Simone M da Costa, Elizabeth Ferreira Rangel, Nataly Araújo de Souza, Vanderlei Campos da Silva, Petr Volf, Claudia Masini d'Avila-Levy
Leishmania braziliensis and Leishmania infantum are the causative agents of cutaneous and visceral leishmaniasis, respectively. Several aspects of the vector-parasite interaction involving gp63 and phosphoglycans have been individually assayed in different studies. However, their role under the same experimental conditions was not studied yet. Here, the roles of divalent metal chelators, anti-gp63 antibodies and purified type I phosphoglycans (PGs) were evaluated during in vitro parasite attachment to the midgut of the vector...
March 29, 2017: Protist
https://www.readbyqxmd.com/read/28460833/application-of-nanotechnology-in-treatment-of-leishmaniasis-a-review
#9
REVIEW
Maryam Akbari, Ahmad Oryan, Gholamreza Hatam
Leishmaniasis is a neglected tropical disease caused by a protozoan species of the genus Leishmania affecting mostly the developing countries. The disease with current mortality rate of 50,000 deaths per year threatens approximately 350 million people in more than 90 countries all over the world. Cutaneous, mucocutaneous and visceral leishmaniasis are the most frequent forms of the disease. Chemotherapy still relies on the use of pentavalent antimonials, amphotericin B, liposomal amphotericin B and miltefosin...
April 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28457848/evaluation-of-methylene-blue-as-photosensitizer-in-promastigotes-of-leishmania-major-and-leishmania-braziliensis
#10
Juliana Guerra Pinto, Jaciara Fagundes, André Henrique Correia Pereira, Josane Mittmann, Leandro José Raniero, Juliana Ferreira-Strixino
The cutaneous leishmaniasis is caused by the protozoan of the genus Leishmania. It is considered by WHO as a public health issue and a neglected disease, which affects rural workers and it is also a risk to travelers in endemic areas. The conventional treatment is toxic and leads to severe side effects. The photodynamic therapy has been studied as an alternative treatment to cutaneous leishmaniasis. This study aimed to evaluate the methylene blue internalization and the impact of the PDT in the viability and morphology of Leishmania major and Leishmania braziliensis promastigote in culture medium...
April 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28446739/suspected-cutaneous-leishmaniasis-in-a-sample-of-westerns-sicily-residents-what-correlation-with-occupation
#11
Maria Gabriella Verso, Fabrizio Vitale, Germano Castelli, Federica Bruno, Antonella Migliazzo, Maria Rita Bongiorno, Fiorella Santi, Giuseppe Pistone, Emanuele Amodio, Diego Picciotto
BACKGROUND: Leishmaniasis is a widespread infectious disease, but there is not much information about its prevalence in high risk occupational categories. OBJECTIVES: The aim of this study is to assess the prevalence of Leishmania immunological positivity in human skin tissues collected from subjects living in Western Sicily, with suspected cutaneous Leishmania infection, in order to explore the risk possibly related to occupation. METHODS: 318 consecutive subjects (M/F ratio=1...
April 21, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28433563/aryl-thiosemicarbazones-in%C3%A2-vitro-and-immunomodulatory-activities-against-l-%C3%A2-amazonensis
#12
Aline Caroline da Silva, Thiago André Ramos Dos Santos, Isis Viviane Bezerra da Silva, Marcos Victor Gregório de Oliveira, Diogo Rodrigo Magalhães Moreira, Ana Cristina Lima Leite, Valéria Rêgo Alves Pereira
Leishmaniasis is an infection caused by different species of Leishmania genus. Currently, there is no vaccine available for Leishmania infections in humans and conventional treatments are limited due to side effects. Therefore, the development of new antileishmanial drugs is an urgent need. In present study, we evaluated the cytotoxicity in host cells, leishmanicidal activity and immunomodulatory potential of seven aryl thiosemicarbazones. Host cell cytotoxicity was determined in peritoneal macrophages of BALB/c mouse, antiparasitic activity was determined against promastigotes and amastigotes of WHOM/00LTB 0016 strain of L...
April 19, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28423087/epidemiological-aspects-of-american-cutaneous-leishmaniasis-acl-in-an-endemic-area-of-forest-extractivist-culture-in-western-brazilian-amazonia
#13
Andreia Fernandes Brilhante, Leonardo Augusto Kohatsu Melchior, Vânia Lúcia Brandão Nunes, Cristiane de Oliveira Cardoso, Eunice Aparecida Bianchi Galati
The study sought to analyze clinical and epidemiological aspects of cutaneous leishmaniasis (CL) in Xapuri, Acre, Brazil. Data from 2008 to 2014 registered in the notification records of the disease of the Information System of the Complaints of Notification (SINAN), and the data of the Information Department of the Unified Health System (DATASUS) available from 2007 to 2013 were used and analyzed in the light of the statistics of the temporal series by the Prais-Winsten method and chi-squared test. A total of 906 cases were registered with 60...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28385151/psychosocial-impact-of-scars-due-to-cutaneous-leishmaniasis-on-high-school-students-in-errachidia-province-morocco
#14
Issam Bennis, Séverine Thys, Hind Filali, Vincent De Brouwere, Hamid Sahibi, Marleen Boelaert
BACKGROUND: In Morocco, cutaneous leishmaniasis (CL) is usually known to be a slowly healing localized skin disease, but in some cases, it can lead to mutilating scars. The outbreak of CL due to Leishmania major in the Errachidia province in southeastern Morocco between 2008 and 2010 left many adolescents with permanent scar tissue on the face or other exposed body parts. We studied the psychosocial impact of CL on these young people. METHODS: In 2015 we conducted a cross-sectional survey among high-school students living in boarding schools in two CL-endemic areas of Errachidia: Rissani and Tinejdad...
April 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28384261/cost-effectiveness-of-meglumine-antimoniate-versus-miltefosine-caregiver-dot-for-the-treatment-of-pediatric-cutaneous-leishmaniasis
#15
Brandon A Berger, Alexandra Cossio, Nancy Gore Saravia, Maria Del Mar Castro, Sergio Prada, Allison H Bartlett, Mai T Pho
BACKGROUND: Oral miltefosine has been shown to be non-inferior to first-line, injectable meglumine antimoniate (MA) for the treatment of cutaneous leishmaniasis (CL) in children. Miltefosine may be administered via in-home caregiver Directly Observed Therapy (cDOT), while patients must travel to clinics to receive MA. We performed a cost-effectiveness analysis comparing miltefosine by cDOT versus MA for pediatric CL in southwest Colombia. METHODOLOGY/PRINCIPLE FINDINGS: We developed a Monte Carlo model comparing the cost-per-cure of miltefosine by cDOT compared to MA from patient, government payer, and societal perspectives (societal = sum of patient and government payer perspective costs)...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28380117/reactivation-of-cutaneous-and-mucocutaneous-tegumentary-leishmaniasis-in-rheumatoid-arthritis-patients-an-emerging-problem
#16
Regina Maia de Souza, Heitor Franco de Andrade, Maria Irma Seixas Duarte, Lucia Maria Almeida Braz, Armando de Oliveira Schubach, Fátima Conceição Silva, Valdir Sabbaga Amato
Rheumatoid arthritis (RA) is a chronic condition that is frequent in patients living in tropical areas exposed to leishmaniasis. RA therapy involves immunosuppressant drugs such as methotrexate (MTX), monoclonal antibodies (mAbs) and prednisone. We report an unusual presentation of cutaneous (CL) or mucocutaneous leishmaniasis (ML) in RA patients from an endemic area of leishmaniasis. A 51-year-old woman noted a cutaneous ulcer on her left ankle during MTX and prednisone RA therapy. Initially diagnosed as a venous stasis ulcer, the aspirate of the injury revealed the presence of Leishmania DNA...
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28379954/risk-factors-for-therapeutic-failure-to-meglumine-antimoniate-and-miltefosine-in-adults-and-children-with-cutaneous-leishmaniasis-in-colombia-a-cohort-study
#17
Maria Del Mar Castro, Alexandra Cossio, Carlos Velasco, Lyda Osorio
INTRODUCTION: Reports of therapeutic failure to meglumine antimoniate (MA) and miltefosine in cutaneous leishmaniasis (CL) varies between species, populations and geographic regions. This study aimed to determine the clinical, drug-related factors, and Leishmania species associated with treatment failure in children and adults with cutaneous leishmaniasis. METHODS: A cohort study was performed with children (2-12 years old) and adults (18-65 years old) with CL, who have participated in clinical studies at CIDEIM Cali, Tumaco and Chaparral...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28367792/safety-and-efficacy-of-current-alternatives-in-the-topical-treatment-of-cutaneous-leishmaniasis-a-systematic-review
#18
Priscila Wolf Nassif, Tatiane França Perles DE Mello, Taísa Rocha Navasconi, Camila Alves Mota, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira
Studies of topical treatments for leishmaniasis were systematically reviewed, to evaluate the therapeutic efficacy, safety and any adverse effects of these treatments. The papers identified in the databases PubMed and Web of Knowledge involved eight studies with a total of 1744 patients. The majority of trials was from Iran (4/8), covered a period of 8 years (2003-2011), and included patients 4-85 years of age. The most frequent Leishmania species in the studies were L. tropica (4/8) and L. major (2/8). The treatments administered were thermotherapy, paromomycin and combinations, CO2 laser, 5-aminolevulinic acid hydrochloride (10%) plus visible red light (633 nm) and cryotherapy...
April 3, 2017: Parasitology
https://www.readbyqxmd.com/read/28349020/treatment-outcome-of-the-drug-resistant-zoonotic-cutaneous-leishmaniasis-by-glucantime
#19
Simindokht Soleimanifard, Reza Arjmand, Sedighe Saberi, Mansoor Salehi, Seyed Hossain Hejazi
BACKGROUND: Resistance of Leishmania species to antimonial drugs has increased. Hence, in the present study Leishmania major isolates were collected from patients with resistance phenotype and the presence/absence of resistance to Glucantime was investigated. MATERIALS AND METHODS: Samples were taken from 10 cutaneous leishmaniasis (CL) patients who had not responded to chemotherapy with Glucantime. Nested polymerase chain reaction (PCR) was performed to identify the isolated species...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28335752/development-of-a-rapid-loop-mediated-isothermal-amplification-assay-for-diagnosis-and-assessment-of-cure-of-leishmania-infection
#20
Sandeep Verma, Ruchi Singh, Vanila Sharma, Ram Avtar Bumb, Narendra Singh Negi, V Ramesh, Poonam Salotra
BACKGROUND: Leishmaniasis is a spectrum of diseases with great relevance to public health. Conventional diagnostic methods are time consuming, needing trained personnel. A robust, rapid and cost effective diagnostic test is warranted for on-time diagnosis and field application. METHODS: We have developed a loop mediated isothermal amplification (LAMP) assay with primers (n = 6) based on Leishmania donovani kDNA for detection of Leishmania infection, using a closed tube to prevent cross-contamination...
March 23, 2017: BMC Infectious Diseases
keyword
keyword
94472
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"