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cutanous leishmaniasis treatment

Vineetha Mandlik, Sohan Patil, Ramanamurthy Bopanna, Sudipta Basu, Shailza Singh
Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin derivatives and their anti-leishmanial properties has been explored both in-vitro and in-vivo. One of the compounds (compound 2) exhibited leishmanicidal activity and to further study its properties, nanoliposomal formulation of the compound was developed...
2016: PloS One
C Cossart, G Le Moal, M Garcia, E Frouin, E Hainaut-Wierzbicka, F Roblot
BACKGROUND: Visceral leishmaniasis is not normally expressed in skin. Herein, we describe the case of an HIV-positive patient who developed two unusual skin manifestations during an episode of visceral leishmaniasis. PATIENTS AND METHODS: A 48-year-old female patient consulted initially for infiltrated purpura of all four limbs. Skin biopsy revealed leukocytoclastic vasculitis with Leishman-Donovan bodies. Laboratory tests showed medullary, splenic, gastric and colic involvement, suggesting systemic disease, and enabling visceral leishmaniasis to be diagnosed...
October 11, 2016: Annales de Dermatologie et de Vénéréologie
Fathima Wardha Refai, Nayani P Madarasingha, Rohini Fernandopulle, Nadira Karunaweera
Leishmaniasis is caused by parasitic protozoa of the genus Leishmania. Cutaneous leishmaniasis (CL) is endemic in Sri Lanka with over 3000 cases during the last decade and numbers are increasing. Treatment options available in Sri Lanka for CL include intralesional/intramuscular sodium stibogluconate and cryotherapy. Eight cases of treatment failure with standard therapy are reported from the Dermatology Clinic, Teaching Hospital Anuradhapura. Therapeutic regimes aim for clinical healing, these patients responded poorly to anti-leishmanial therapy, indicating the need for close monitoring, explore alternative treatment options and to investigate for drug resistance in parasites...
July 2016: Tropical Parasitology
Eva Iniguez, Armando Varela-Ramirez, Alberto Martínez, Caresse L Torres, Roberto A Sánchez-Delgado, Rosa A Maldonado
In previous studies we reported a novel series of organometallic compounds, Ru(II) complexed with clotrimazole, displaying potent trypanosomatid activity with unnoticeable toxicity toward normal mammalian cells. In view of the promising activity of Ru-clotrimazole complexes against Leishmania major (L. major), the present work sought to investigate the anti-leishmanial activity of the AM162 complex in the murine model of cutaneous leishmaniasis. In addition, to facilitate the design of new therapeutic strategies against this disease, we investigated the mode of action of two Ru-clotrimazole complexes in L...
September 30, 2016: Acta Tropica
Manisha Balai, Lalit Kumar Gupta, Ashok Kumar Khare, Ankita Srivastava, Asit Mittal, Ajit Singh
BACKGROUND: Cutaneous leishmaniasis (CL) usually occurs in areas with hot and dry climate. In India, the desert areas of Rajasthan, Gujarat, and the plains of Northwestern frontier are endemic for this disorder. AIMS AND OBJECTIVES: The present study was aimed to describe clinicoepidemiological profile of the cases of CL from South Rajasthan, which is a nonendemic area of Rajasthan. MATERIALS AND METHODS: During a period of 4 years (2010-2014), a total of 23 patients with CL were diagnosed...
September 2016: Indian Journal of Dermatology
Lissa Cruz-Saavedra, Andrea Díaz-Roa, María A Gaona, Mónica L Cruz, Martha Ayala, Jesús A Cortés-Vecino, Manuel A Patarroyo, Felio J Bello
This study's main objective was to evaluate the action of larval therapy derived from Lucilia sericata and Sarconesiopsis magellanica (blowflies) regarding Leishmania panamensis using an in vivo model. Eighteen golden hamsters (Mesocricetus auratus) were used; they were divided into 6 groups. The first three groups consisted of 4 animals each; these, in turn, were internally distributed into subgroups consisting of 2 hamsters to be used separately in treatments derived from each blowfly species. Group 1 was used in treating leishmanial lesions with larval therapy (LT), whilst the other two groups were used for evaluating the used of larval excretions and secretions (ES) after the ulcers had formed (group 2) and before they appeared (group 3)...
September 26, 2016: Acta Tropica
Marzieh Fattahi-Dolatabadi, Tahereh Mousavi, Hajar Mohammadi-Barzelighi, Saeed Irian, Bita Bakhshi, Mohammad-Ali Nilforoushzadeh, Leila Shirani-Bidabadi, Mohammad-Mahdi Hariri, Nazli Ansari, Nahid Akbari
BACKGROUND & OBJECTIVES: Association between polymorphisms in the natural resistance associated macrophage protein 1 (NRAMP1) gene and susceptibility to cutaneous leishmaniasis (CL) has been demonstrated worldwide; however, the reported results were inconsistent. This study aimed to determine the association of NRAMP1 variants with susceptibility to CL infection and patients' response to treatment in Isfahan province of Iran. METHODS: Peripheral blood samples were collected from 150 patients with CL and 136 healthy controls...
July 2016: Journal of Vector Borne Diseases
Marcelo Rosandiski Lyra, Sonia Regina Lambert Passos, Maria Inês Fernandes Pimentel, Sandro Javier Bedoya-Pacheco, Cláudia Maria Valete-Rosalino, Erica Camargo Ferreira Vasconcellos, Liliane Fatima Antonio, Mauricio Naoto Saheki, Mariza Mattos Salgueiro, Ginelza Peres Lima Santos, Madelon Noato Ribeiro, Fatima Conceição-Silva, Maria Fatima Madeira, Jorge Luiz Nunes Silva, Aline Fagundes, Armando Oliveria Schubach
American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are the first choice drugs for cutaneous leishmaniasis (CL), although doses are controversial. In a clinical trial for CL we investigated the occurrence of pancreatic toxicity with different schedules of treatment with meglumine antimoniate (MA). Seventy-two patients were allocated in two different therapeutic groups: 20 or 5 mg of pentavalent antimony (Sb5+)/kg/day for 20 or 30 days, respectively...
2016: Revista do Instituto de Medicina Tropical de São Paulo
M de Wild, F H Wiersma, T F W Wolfs, P M van Hasselt
BACKGROUND: Cutaneous leishmaniasis is rare in the Netherlands, but it is endemic to Syria. The disease can manifest itself many years after initial exposure. Given the arrival of Syrian refugees in the Netherlands, awareness of this disease entity is warranted. CASE DESCRIPTION: A 5-year-old boy from Syria had investigations for hepatosplenomegaly. As an incidental finding a solitary, moderately demarcated, erythematous plaque was noted on his right cheek. It measured 4 × 2 cm and had a central haemorrhagic, exudative, honey-yellow slough...
2016: Nederlands Tijdschrift Voor Geneeskunde
Carmen María Alcántara-Reifs, Gloria Garnacho-Saucedo, Rafael Salido-Vallejo, Antonio Vélez García-Nieto
No abstract text is available yet for this article.
September 16, 2016: Dermatologic Therapy
Suraj P Parihar, Mary-Anne Hartley, Ramona Hurdayal, Reto Guler, Frank Brombacher
We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here, we investigated the immunomodulatory potential of simvastatin as a topical or systemic host-directed drug therapy in controlling inflammatory responses in an experimental mouse model of cutaneous leishmaniasis caused by Leishmania major (LV39). In an ear infection model, topical application of simvastatin directly on established lesions significantly reduced severity of the disease reflected by ear lesion size and ulceration...
2016: Scientific Reports
Victoriano Corpas-López, Gemma Merino-Espinosa, Margarita López-Viota, Patricia Gijón-Robles, María Jesús Morillas-Mancilla, Julian López-Viota, Victoriano Díaz-Sáez, Francisco Morillas-Márquez, María Concepción Navarro Moll, Joaquina Martín-Sánchez
There is currently no reliable treatment for the management of cutaneous leishmaniasis, and intralesional antimonial injections remain the main treatment. The present work aims at evaluating the antileishmanial effectiveness and safety of (-)-α-bisabolol (1) in a novel topical formulation on a cutaneous leishmaniasis model involving Leishmania tropica-infected Syrian hamsters. The topical treatment with 1 reduced lesion thickness to 56% at 2.5%, showing a higher efficacy than the reference control, meglumine antimoniate...
September 23, 2016: Journal of Natural Products
Saeedeh Farajzadeh, Maryam Hakimi Parizi, Ali Akbar Haghdoost, Azadeh Mohebbi, Saman Mohammadi, Abbas Pardakhty, Sana Eybpoosh, Amireh Heshmatkhah, Behrooz Vares, Simin Saryazdi, Ali Reza Fekri, Elham Mohebbi
Zinc sulfate (ZS) has been used for the treatment of acute cutaneous leishmaniasis (CL) in both forms of in vivo and in vitro recently. The aim of the present study was to compare the efficacy of intralesional injection of ZS 2 % solution with intralesional glucantime in the treatment of acute CL. In this double-blind randomized clinical trial, 80 cases with acute old world dry type CL were enrolled in the study. The treatment protocol in the first group consisted of intralesional injection of ZS 2 % vials once a week for 10 weeks or sooner in case of complete resolution of the lesions...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Alireza Sanei-Dehkordi, Ali Khamesipour, Kamran Akbarzadeh, Amir Ahmad Akhavan, Akram Mir Amin Mohammadi, Younes Mohammadi, Yavar Rassi, Mohammad Ali Oshaghi, Zahra Alebrahim, Seyed Ebrahim Eskandari, Javad Rafinejad
Use of sterile fly larvae (maggots) of blow flies for the treatment of many different types of skin and soft tissue wounds is called Maggot debridement therapy (MDT). The larvae of blow flies secrete a broad spectrum of compounds with diverse mechanisms of action in the gut and salivary glands called excretion/secretion (ES) products which showed to have antimicrobial activities against Gram negative and positive bacteria. Cutaneous leishmaniasis (CL) which is the common form of leishmaniasis is difficult to treat...
August 24, 2016: Experimental Parasitology
Anila Chacko, Marissa Joseph, Timothy Feltis, Shaun K Morris
It is challenging to find safe, nonscarring and noninvasive treatment of facial cutaneous leishmaniasis (CL) in children. Herein, we report a child with CL from a region endemic for Leishmania tropica, whose lesion persisted after treatment with oral fluconazole but responded to topical paromomycin. Paromomycin should be considered early for treatment of Old World CL and is a well-tolerated and effective mode of therapy for facial lesions.
October 5, 2016: American Journal of Tropical Medicine and Hygiene
V Corpas-López, G Merino-Espinosa, V Díaz-Sáez, F Morillas-Márquez, M C Navarro-Moll, J Martín-Sánchez
Cutaneous leishmaniasis treatment remains challenging due to the absence of a satisfactory treatment. The screening of natural compounds is a valuable strategy in the search of new drugs against leishmaniasis. The sesquiterpene (-)-α-bisabolol is effective in vivo against visceral leishmaniasis due to Leishmania infantum, but its mechanism of action remains elusive. The aim of this study is to validate this promising compound against the causative species of Old World cutaneous leishmaniasis and to get an insight into its antileishmanial mode of action...
October 2016: Apoptosis: An International Journal on Programmed Cell Death
Rosiana Estéfane da Silva, Antonio Toledo, Maria Camilo Senna, Ana Rabello, Gláucia Cota
Although intralesional meglumine antimoniate (MA) infiltration is considered an option for cutaneous leishmaniasis (CL) therapy and is widely used in the Old World, there have been few studies supporting this therapeutic approach in the Americas. This study aims to describe outcomes and adverse events associated with intralesional therapy for CL. This retrospective study reviewed the experience of a Brazilian leishmaniasis reference centre using intralesional MA to treat 31 patients over five years (2008 and 2013)...
August 2016: Memórias do Instituto Oswaldo Cruz
Sabha Mushtaq, Devraj Dogra, Naina Dogra
Cutaneous leishmaniasis (CL) is a vector-borne tropical disease caused by a heterogeneous group of protozoan parasites that belong to the genus Leishmania. With an annual incidence of 1.5 million new cases, CL is a global health concern mainly in developing countries. The treatment options for CL are numerous but none is optimal. Pentavalent antimonials despite their side effects remain the preferred choice since decades. Alternate new treatment options are being explored to expand the therapeutic armamentarium of CL...
August 1, 2016: Dermatologic Therapy
Guru R Valicherla, Priyanka Tripathi, Sandeep K Singh, Anees A Syed, Mohammed Riyazuddin, Athar Husain, Deep Javia, Kishan S Italiya, Prabhat R Mishra, Jiaur R Gayen
Miltefosine (MFS) is the first effective oral drug for treatment of visceral, mucosal and cutaneous leishmaniasis. In this study, liquid chromatography coupled mass spectrometry (LC-MS/MS) method of MFS was validated in rat plasma and its practical utilization to pharmacokinetic studies in rats for the first time. A rapid, selective and sensitive LC-MS/MS method for MFS in rat plasma was linear over the calibration range of 1-500ng/mL. MFS and Phenacetin (internal standard) were separated on Phenomenex Luna 3μ HILIC 200A (150×4...
September 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Farnaz Kheirandish, Bahram Delfan, Hossein Mahmoudvand, Nasim Moradi, Behrouz Ezatpour, Farzad Ebrahimzadeh, Marzieh Rashidipour
Currently, there is no effective vaccine available, and chemotherapy is the main approach for treatment of cutaneous leishmaniasis (CL). During recent decades, studies have demonstrated that a number of plant-derived compounds may act as new therapeutic tools against leishmaniasis. This study was evaluated the antileishmanial, antioxidant, and cytotoxic activities of Quercus infectoria Olivier (oak) extract. The total amount of phenolic and flavonoid compounds was measured in oak extract. High performance liquid chromatography (HPLC) analysis was also performed to determine the amount of quercetin and gallic acid in this plant...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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