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cutanous leishmaniasis treatment

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https://www.readbyqxmd.com/read/28096850/expression-analysis-of-multiple-genes-may-involve-in-antimony-resistance-among-leishmania-major-clinical-isolates-from-fars-province-central-iran
#1
Nafiseh Ghobakhloo, Mohammad Hossein Motazedian, Majid Fardaei
BACKGROUND: Treatment of Cutaneous Leishmaniasis (CL) is being faced with serious difficulties in Fars Province, due to emerging of resistance against meglumine antimonite (Glucantime®). In this context, determining some biomarkers for drug sensitivity monitoring seems to be highly essential. Different studies have been carried out to decipher the genes might be involved in antimony resistant phenotype in Leishmania spp. Here, we selected three genes: AQP (as drug transporter), TDR-1-1(as drug activator), and γ-GCS (inducing reduction environment) for comparative expression analysis on clinical resistant and sensitive isolates of L...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28071592/development-and-evaluation-of-zinc-phthalocyanine-nanoemulsions-for-use-in-photodynamic-therapy-for-leishmania-spp
#2
Luciana Betzler de Oliveira de Siqueira, Verônica da Silva Cardoso, Igor Almeida Rodrigues, Ana Lúcia Vazquez-Villa, Elisabete Pereira Dos Santos, Bruno da Costa Leal Ribeiro Guimarães, Cristal Dos Santos Cerqueira Coutinho, Alane Beatriz Vermelho, Eduardo Ricci Junior
Photodynamic therapy (PDT) combines light with photosensitizers (PS) for production of reactive oxygen species (ROS) that can kill infectious microorganisms such as bacteria, fungi and protozoa. The application of nanotechnology has enabled the advancement of PDT because many PS are insoluble in water, necessitating a nanocarrier as a physiologically acceptable carrier. Nanoemulsions are efficient nanocarriers for solubilizing liposoluble drugs, like the PS, in water. Cutaneous (CL) and mucocutaneous leishmaniasis (ML) are caused by different species of the genus Leishmania, transmitted to humans by sandfly bites...
February 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28052994/local-delivery-of-the-tlr9-ligand-cpg-down-regulates-host-immune-and-inflammatory-responses-ameliorating-established-leishmania-viannia-panamensis-chronic-infection
#3
Allison K Ehrlich, Olga L Fernández, Daniel Rodriguez-Pinto, Tiago M Castilho, Maria J Corral Caridad, Karen Goldsmith-Pestana, Nancy Gore Saravia, Diane McMahon-Pratt
Infection by Leishmania (Viannia) panamensis, the predominant etiologic agent for cutaneous leishmaniasis in Colombia, is characterized by a chronic mixed-inflammatory response. Current treatment options are plagued by toxicity, lengthy treatment regimens and growing evidence of drug resistance. Immunotherapy, modulating the immune system to mount a protective response, may provide an alternate therapeutic approach. We investigated the ability of the TLR9 ligand, CpG, to modulate established disease in the L...
January 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28043177/the-pulsed-dye-laser-is-more-effective-and-rapidly-acting-than-intralesional-meglumine-antimoniate-therapy-for-cutaneous-leishmaniasis
#4
Mohammad Radmanesh, Ehsan Omidian
BACKGROUND AND OBJECTIVE: The Pulsed dye laser (PDL) is not tested yet for the treatment of cutaneous leishmaniasis (CL). We compared the efficacy of 585nm PDL with intralesional meglumine antimoniate (MA) on 17 patients with 81 lesions of cutaneous leishmaniasis. PATIENTS AND METHOD: Out of the 81 lesions, 42 lesions were treated with one or two passes of PDL fortnightly and 39 lesions in the same patients were treated with intralesional MA weekly. The fluence chosen for the laser was 7 Joules/cm2 with 5mm spot size...
January 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28011169/leishmanicidal-activity-of-the-alkaloid-rich-fraction-from-guatteria-latifolia
#5
C Ferreira, C L A Passos, D C Soares, K P Costa, M J C Rezende, A Q Lobão, A C Pinto, L Hamerski, E M Saraiva
Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania and includes cutaneous, mucocutaneous and visceral clinical forms. The drugs currently available for leishmaniasis treatment are pentavalent antimonials, amphotericin B and miltefosine, which present high toxicity, elevated cost and development of parasite resistance. The natural products constitute an important source of substances with leishmanicidal potential. Here we evaluated in vitro the anti-Leishmania amazonensis activity of crude extracts of branches, leaves and fruits of Guatteria latifolia...
December 21, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/28008252/nanoscaled-hydrated-antimony-v-oxide-as-a-new-approach-to-first-line-antileishmanial-drugs
#6
Antonia Mr Franco, Iryna Grafova, Fabiane V Soares, Gennaro Gentile, Claudia Dc Wyrepkowski, Marcos A Bolson, Ézio Sargentini, Cosimo Carfagna, Markku Leskelä, Andriy Grafov
BACKGROUND: Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V) complexes are commercialized as sodium stibogluconate (Pentostam(®)) and meglumine antimoniate (MA) (Glucantime(®)). Ever-increasing drug resistance in the parasites limits the use of antimonials, due to the low drug concentrations being administered against high parasitic counts. Sb(5+) toxicity provokes severe side effects during treatment...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28001228/standardization-of-intralesional-meglumine-antimoniate-treatment-for-cutaneous-leishmaniasis
#7
Maria Cristina de Oliveira Duque, Érica de Camargo Ferreira E Vasconcellos, Maria Inês Fernandes Pimentel, Marcelo Rosandiski Lyra, Sandro Javier Bedoya Pacheco, Mauro Celio de Almeida Marzochi, Cláudia Maria Valete Rosalino, Armando de Oliveira Schubach
INTRODUCTION: Intralesional treatment for cutaneous leishmaniasis has been applied for over 30 years at the Oswaldo Cruz Foundation, Rio de Janeiro, with good therapeutic results and without relevant systemic toxicity. METHODS: Meglumine antimoniate was injected subcutaneously, using a long medium-caliber needle (for example, 30mm × 0.8mm); patients received 1-3 injections, with 15-day intervals. RESULTS: The technique is described in detail sufficient to enable replication...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27999013/pharmacological-inhibition-of-p110%C3%AE-subunit-of-pi3k-confers-protection-against-experimental-leishmaniasis
#8
Forough Khadem, Ping Jia, Zhirong Mou, Aida Feiz Barazandeh, Dong Liu, Yoav Keynan, Jude E Uzonna
OBJECTIVES: This study aimed to evaluate the immuno-prophylactic and -therapeutic effect of p110δ-specific pharmacological inhibitors (CAL-101 and IC87114), either alone or in combination with amphotericin B, against experimental cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). METHODS: Female BALB/c mice were infected intravenously with Leishmania donovani or subcutaneously with Leishmania major Prophylactic treatment was initiated 24 h prior to infection, whereas therapeutic treatments with or without amphotericin B were initiated either 1 week or 2 weeks post-infection...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27986151/leishmania-tropica-combined-debulking-and-imiquimod-for-the-treatment-of-nonresponsive-cutaneous-leishmaniasis
#9
Laura A Taylor, Rachel Gormley, Carrie Kovarik
No abstract text is available yet for this article.
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27965662/visceral-leishmaniasis-patients-display-altered-composition-and-maturity-of-neutrophils-as-well-as-impaired-neutrophil-effector-functions
#10
Endalew Yizengaw, Mulusew Getahun, Fitsumbrhan Tajebe, Edward Cruz Cervera, Emebet Adem, Getnet Mesfin, Asrat Hailu, Gert Van der Auwera, Vanessa Yardley, Mulualem Lemma, Ziv Skhedy, Ermias Diro, Arega Yeshanew, Roma Melkamu, Bewketu Mengesha, Manuel Modolell, Markus Munder, Ingrid Müller, Yegnasew Takele, Pascale Kropf
Immunologically, active visceral leishmaniasis (VL) is characterized by profound immunosuppression, severe systemic inflammatory responses, and an impaired capacity to control parasite replication. Neutrophils are highly versatile cells, which play a crucial role in the induction as well as the resolution of inflammation, the control of pathogen replication, and the regulation of immune responses. Neutrophil functions have been investigated in human cutaneous leishmaniasis; however, their role in human VL is poorly understood...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27960617/nuclear-dna-replication-and-repair-in-parasites-of-the-genus-leishmania-exploiting-differences-to-develop-innovative-therapeutic-approaches
#11
Graciela Uzcanga, Eliana Lara, Fernanda Gutiérrez, Doyle Beaty, Timo Beske, Rommy Teran, Juan-Carlos Navarro, Philippe Pasero, Washington Benítez, Ana Poveda
Leishmaniasis is a common tropical disease that affects mainly poor people in underdeveloped and developing countries. This largely neglected infection is caused by Leishmania spp, a parasite from the Trypanosomatidae family. This parasitic disease has different clinical manifestations, ranging from localized cutaneous to more harmful visceral forms. The main limitations of the current treatments are their high cost, toxicity, lack of specificity, and long duration. Efforts to improve treatments are necessary to deal with this infectious disease...
December 14, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27957467/first-report-on-infant-acute-urticaria-after-mother-s-parenteral-use-of-meglumine-antimoniate-glucantime-a-case-report
#12
Omid Mozafari, Seyed Afshin Shorofi, Seyde Sedighe Yousefi
Pentavalent antimonials are still the first drug of choice for the treatment of cutaneous leishmaniasis (CL). Like other treatments, they can cause adverse reactions including musculoskeletal pain, gastrointestinal disturbances, and mild to moderate headaches. In this paper, we report the first case of an infant who developed acute urticaria after her mother's parenteral use of meglumine antimoniate (glucantime).
September 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27957441/therapeutic-effect-of-scrophularia-striata-ethanolic-extract-against-localized-cutaneous-leishmaniasis-caused-by-leishmania-major-mrho-ir-75-er
#13
Malihe Zahiri, Mehdi Mohebali, Mahnaz Khanavi, Mousa Sahebgharani, Abedin Saghafipour, Jamileh Esmaeili, Homa Hajjaran, Amir Ahmad Akhavan, Seyed Mahdi Rezayat
BACKGROUND: We evaluated the effect of the ethanolic extract of Scrophularia striata on the Iranian strain of Leishmania major (MRHO/IR/75/ER) both in vitro and in vivo conditions. METHODS: The effective dose (ED) of ethanolic extract of S. striata were determined using MTT assay on the growth of promastigote forms of L. major in axenic culture media. Then, the ED50 of S. striata on mice peritoneal macrophages was determined using calculation of amastigote forms on mice peritoneal macrophages...
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27956421/pharmacokinetics-of-miltefosine-in-children-and-adults-with-cutaneous-leishmaniasis
#14
María Del Mar Castro, Maria Adelaida Gomez, Anke E Kip, Alexandra Cossio, Eduardo Ortiz, Adriana Navas, Thomas P C Dorlo, Nancy Gore Saravia
AIMS AND DESIGN: An open label, pharmacokinetics clinical trial was conducted to comparatively assess the pharmacokinetics (PK) and explore the pharmacodynamics (PD) of miltefosine in children and adults with cutaneous leishmaniasis in Colombia. METHODS: Sixty patients, 30 children aged 2-12 years and 30 adults aged 18-60 years were enrolled. Participants received miltefosine (Impavido®) at a nominal dose of 2.5 mg/kg/day for 28 days. Miltefosine concentrations were measured in plasma and peripheral blood mononuclear cells by liquid chromatography tandem-mass spectrometry of samples obtained during treatment and up to six months following completion of treatment, when therapeutic outcome was determined...
December 12, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27922065/detc-based-bacterial-cellulose-bio-curatives-for-topical-treatment-of-cutaneous-leishmaniasis
#15
Fabiana S Celes, Eliane Trovatti, Ricardo Khouri, Johan Van Weyenbergh, Sidney J L Ribeiro, Valeria M Borges, Hernane S Barud, Camila I de Oliveira
The treatment of leishmaniasis still relies on drugs with potentially serious adverse effects. Herein, we tested a topical formulation of bacterial cellulose (BC) membranes containing Diethyldithiocarbamate (DETC), a superoxide dismutase 1 inhibitor. Leishmania-infected macrophages exposed to BC-DETC resulted in parasite killing, without pronounced toxic effects to host cells. This outcome was associated with lower SOD1 activity and higher production of superoxide and cytokine mediators. Topical application of BC-DETC significantly decreased lesion size, parasite load and the inflammatory response at the infection site, as well as the production of both IFN-γ and TNF...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27890957/unusual-presentation-of-mucocutaneous-leishmaniasis-in-hiv-infected-patient
#16
Anupama Bains, Deepak Vedant, Priyanka Gupta, G R Tegta
Leishmaniasis is caused by protozoan parasite of genus leishmania. Visceral leishmaniasis, diffuse cutaneous leishmaniasis, and atypical forms of cutaneous leishmaniasis are common in HIV-infected patients. Our patient presented with an obstructive mass in nasal cavity and was diagnosed as a case of mucocutaneous leishmaniasis. Spontaneous healing of lesions in HIV-infected patients is rare rather they are unresponsive to treatment and have frequent relapses, especially in patients with low CD4 count. However, in our patient, the lesion improved significantly after 2 months of highly active antiretroviral therapy and co-trimoxazole prophylaxis...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27886396/5-ala-mediated-photodynamic-therapy-reduces-the-parasite-load-in-mice-infected-with-leishmania-braziliensis
#17
Danila Malheiros Souza, Polyanna Miranda Alves, Mona Lisa Fabiana Silva, Tony Paiva Paulino, Henrique Ovidio Coraspe, Mônica Miguel Sawan Mendonça, Betânia Maria Ribeiro, Marcos Vinicius da Silva, Virmondes Rodrigues Júnior, Denise Bertulucci Rocha Rodrigues
INTRODUCTION: Photodynamic therapy (PDT) has proven to be an effective alternative for the treatment of cutaneous leishmaniasis. Skin lesions consist of ulcers with well-defined raised edges, and granular floor. Th1 immune response is the protective profile in patients infected with Leishmania. In the present study, the photodynamic therapy with 5-aminolevulinic acid, the parasitic load, and the modulation of the immune response were evaluated in mice infected with Leishmania braziliensis...
November 25, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27876985/in-vitro-anti-leishmanial-activity-of-satureja-hortensis-and-artemisia-dracunculus-extracts-on-leishmania-major-promastigotes
#18
Farzaneh Mirzaei, Ali Fattahi Bafghi, Mohammad Ali Mohaghegh, Hossein Zarei Jaliani, Roghiyeh Faridnia, Hamed Kalani
Cutaneous leishmaniasis is one of the important skin diseases with diverse clinical manifestations. With an incidence of 0.7-1.3 million cases annually, this disease is often reported from six countries, including Iran. Accordingly, the purpose of this study was to evaluate the anti-leishmanial effect of the three plant hydroalcoholic extracts including fleawort (Plantago psyllium L.), savory (Satureja hortensis L.) and tarragon (Artemisia dracunculus L.) on Leishmania major promastigotes. The hydroalcoholic extract from each plant was extracted and its anti-leishmanial effect was evaluated in different concentrations (100-1000 µg/ml) and at various hours (24, 48 and 72 h)...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876906/topical-terbinafine-in-the-treatment-of-cutaneous-leishmaniasis-triple-blind-randomized-clinical-trial
#19
Saeedeh Farajzadeh, Amireh Heshmatkhah, Behrooz Vares, Elham Mohebbi, Azadeh Mohebbi, Mahin Aflatoonian, Sana Eybpoosh, Iraj Sharifi, Mohammad Reza Aflatoonian, Simin Shamsi Meymandi, Ali Reza Fekri, Mahshid Mostafavi
Leishmaniasis is a spectrum of disease condition with considerable health impacts, caused by different species of Leishmania. This disease is currently endemic in 98 countries and territories in the world. There are many treatment modalities for cutaneous leishmaniasis. The use of topical terbinafine in the treatment of cutaneous leishmaniasis has recently been considered. Eighty-eight participants more than two years old with proven acute CL by a positive direct smear were randomly allocated to one of the two study arms: first group received meglumine antimoniate (Glucantime) 20 mg/kg/day intramuscular injection (IM) plus a placebo ointment (Mahan Vaseline) for 20 days...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27834055/biopharmaceutical-assessment-and-irritation-potential-of-microemulsions-and-conventional-systems-containing-oil-from-syagrus-cearensis-for-topical-delivery-of-amphotericin-b-using-alternative-methods
#20
Giovana D Sousa, Juliana Kishishita, Kátia A S Aquino, Octávio A F Presgrave, Leila B Leal, Davi P Santana
The aim of this study was to compare the biopharmaceutical characteristics and irritation potentials of microemulsions (MEs) and conventional systems (CSs) containing oil from Syagrus cearensis for topical delivery of Amphotericin B (AmB). Pseudo-ternary phase diagrams were constructed using a water titration method to develop the MEs, and the CSs were prepared according to the classical technique of phase inversion. In the skin permeation and retention study, dermatomed pig skin without stratum corneum was used as an alternative disturbed skin model...
November 10, 2016: AAPS PharmSciTech
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