Letizia Santinelli, Alessandro Lazzaro, Francesca Sciarra, Luca Maddaloni, Federica Frasca, Matteo Fracella, Sonia Moretti, Alessandra Borsetti, Ginevra Bugani, Francesco Alessandri, Veronica Zullino, Franco Ruberto, Francesco Pugliese, Leonardo Sorrentino, Daniele Gianfrilli, Andrea Isidori, Mary Anna Venneri, Claudio M Mastroianni, Giancarlo Ceccarelli, Gabriella d'Ettorre
BACKGROUND: SARS-CoV-2 related immunopathology may be the driving cause underlying severe COVID-19. Through an immunophenotyping analysis on paired bronchoalveolar lavage fluid (BALF) and blood samples collected from mechanically ventilated patients with COVID-19-associated Acute Respiratory Distress Syndrome (CARDS), this study aimed to evaluate the cellular immune responses in survivors and non-survivors of COVID-19. METHODS: A total of 36 paired clinical samples of bronchoalveolar lavage fluid (BALF) mononuclear cells (BALF-MC) and peripheral blood mononuclear cells (PBMC) were collected from 18 SARS-CoV-2-infected subjects admitted to the intensive care unit (ICU) of the Policlinico Umberto I, Sapienza University Hospital in Rome (Italy) for severe interstitial pneumonia...
March 11, 2023: Pathogens