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https://www.readbyqxmd.com/read/28392435/sex-specific-differences-in-colon-cancer-when-quality-measures-are-adhered-to-results-from-international-prospective-multicenter-clinical-trials
#1
Shrawan G Gaitonde, Aviram Nissan, Mladjan Protić, Alexander Stojadinovic, Zev A Wainberg, David C Chen, Anton J Bilchik
INTRODUCTION: There is no consensus on the relationship between patient sex and the location, stage and oncologic outcome of colon cancer (CC). We hypothesized a sex-specific difference in the biology and management of CC. STUDY DESIGN: Our cohort was drawn from a database of patients enrolled in international trials of nodal ultrastaging for non-metastatic CC. These trials required strict adherence to surgical and pathological quality measures. Postoperative follow-up included colonoscopy at 1 and 4 years and annual CT scans...
April 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28380627/promoting-cancer-screening-among-churchgoing-latinas-fe-en-acci%C3%A3-n-faith-in-action
#2
J P Elder, J Haughton, L G Perez, M E Martínez, C L De la Torre, D J Slymen, E M Arredondo
Cancer screening rates among Latinas are generally low, reducing the likelihood of early cancer detection in this population. This article examines the effects of a community intervention (Fe en Acción/Faith in Action) led by community health workers (promotoras) on promoting breast, cervical and colorectal cancer screening among churchgoing Latinas. Sixteen churches were randomly assigned to a cancer screening or a physical activity intervention. We examined cancer knowledge, barriers to screening and self-reported mammography, clinical breast exam, Pap test, fecal occult blood test and sigmoidoscopy or colonoscopy at baseline and 12 months follow-up...
April 1, 2017: Health Education Research
https://www.readbyqxmd.com/read/28373768/colonic-ulcerations-may-predict-steroid-refractory-course-in-patients-with-ipilimumab-mediated-enterocolitis
#3
Animesh Jain, Evan J Lipson, William H Sharfman, Steven R Brant, Mark G Lazarev
AIM: To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy. METHODS: We retrospectively reviewed all patients at our center with metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression...
March 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28336719/colon-cancer-screening-among-patients-receiving-dialysis-in-the-united-states-are-we-choosing-wisely
#4
Christopher A Carlos, Charles E McCulloch, Chi-Yuan Hsu, Barbara Grimes, Meda E Pavkov, Nilka R Burrows, Vahakn B Shahinian, Rajiv Saran, Neil R Powe, Kirsten L Johansen
The American Society of Nephrology recommends against routine cancer screening among asymptomatic patients receiving maintenance dialysis on the basis of limited survival benefit. To determine the frequency of colorectal cancer screening among patients on dialysis and the extent to which screening tests were targeted toward patients at lower risk of death and higher likelihood of receiving a kidney transplant, we performed a cohort study of 469,574 Medicare beneficiaries ages ≥50 years old who received dialysis between January 1, 2007 and September 30, 2012...
March 23, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28296471/the-safety-of-multiple-flexible-sigmoidoscopies-with-mucosal-biopsies-in-healthy-clinical-trial-participants
#5
Wai Kan Chiu, Rhonda M Brand, Danielle Camp, Stacey Edick, Carol Mitchell, Sherri Karas, Amanda Zehmisch, Ken Ho, Randall E Brand, Janet Harrison, Steven Abo, Ross D Cranston, Ian McGowan
During Phase 1 pharmacokinetic/pharmacodynamics studies, participants may undergo multiple sigmoidoscopies, with a collection of 10-20 biopsies during each procedure. This article characterizes the safety of flexible sigmoidoscopies in clinical trial participants. We determined the number of flexible sigmoidoscopies and rectal biopsies that participants underwent and analyzed the frequency, duration, and severity of flexible sigmoidoscopy-related adverse events (AEs). During the study period, 278 participants underwent 1,004 flexible sigmoidoscopies with the collection of 15,930 rectal biopsies...
March 15, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28283508/absolute-risk-reductions-in-paper-on-flexible-sigmoidoscopy
#6
John Doherty
No abstract text is available yet for this article.
March 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28267007/twenty-years-of-a-veterans-spinal-cord-injury-colorectal-clinic-flexible-sigmoidoscopy-and-multiple-hemorrhoid-ligation
#7
Bard C Cosman, Luis C Cajas-Monson, Sonia L Ramamoorthy
BACKGROUND: Colorectal and anal problems arise in chronic spinal cord injury care. We review 20 years of experience in a colorectal clinic at a veterans medical center treating mostly male veterans who have spinal cord injury. OBJECTIVE: We aim to show the results of colorectal interventions in a population with chronic spinal cord injury. DESIGN: This study is a retrospective records review. SETTINGS: This study was conducted at a Department of Veterans Affairs regional spinal cord injury center...
April 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28256902/the-role-of-colonoscopy-and-ct-colonography-in-patients-presenting-with-symptoms-of-constipation
#8
Kumaran Ratnasingham, Tammy Lo, Karim Jamal, Lavanya Varatharajan, Yasmin Tabbakh, Hussein Kaderbhai, Nicholas J West
OBJECTIVES: There is controversy whether constipation as a primary presenting complaint is an indication for diagnostic colonoscopy. Computed tomographic colonography (CTC) is a less invasive and more acceptable alternative. We compared the completion and sensitivity of colonoscopy with CTC in patients who presented with the primary symptom of constipation. METHOD: A retrospective study was conducted which examined the first 100 colonoscopies and 100 CTCs carried out for the primary symptom of constipation from June 2012 to December 2013...
March 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28252461/the-effect-of-a-health-education-intervention-on-jordanian-participants-colorectal-cancer-knowledge-health-perceptions-and-screening-practices
#9
Fuad H Abuadas, Wasileh J Petro-Nustas, Mohammad H Abuadas
BACKGROUND: Globally, colorectal cancer (CRC) is the second and third most commonly diagnosed cancer in women and men, respectively. OBJECTIVES: The aim of this study is to test the effectiveness of a health education intervention on the current level of Jordanians' CRC knowledge, health perceptions, and screening practices. METHODS: A convenience sampling method was used to recruit a sample of 197 average-risk Jordanian adults aged 50 to 75 years...
March 1, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28236467/long-term-effects-of-once-only-flexible-sigmoidoscopy-screening-after-17-years-of-follow-up-the-uk-flexible-sigmoidoscopy-screening-randomised-controlled-trial
#10
Wendy Atkin, Kate Wooldrage, D Maxwell Parkin, Ines Kralj-Hans, Eilidh MacRae, Urvi Shah, Stephen Duffy, Amanda J Cross
BACKGROUND: Colorectal cancer is the third most common cancer worldwide. Previous analyses have only reported follow-up after flexible sigmoidoscopy for a maximum of 12 years. We aimed to examine colorectal cancer incidence and mortality after a single flexible sigmoidoscopy screening and 17 years of follow-up. METHODS: In this multicentre randomised trial (UK Flexible Sigmoidoscopy Screening Trial), done between Nov 14, 1994, and March 30, 1999, 170 432 eligible men and women, who had indicated on a previous questionnaire that they would probably attend screening if invited, were randomly assigned (1:2) to an intervention group (offered flexible sigmoidoscopy screening) or a control group (not contacted)...
April 1, 2017: Lancet
https://www.readbyqxmd.com/read/28236465/flexible-sigmoidoscopy-screening-is-once-enough
#11
Paul F Pinsky
No abstract text is available yet for this article.
February 21, 2017: Lancet
https://www.readbyqxmd.com/read/28235850/one-off-sigmoidoscopy-screening-cuts-bowel-cancer-risk-for-17-years-uk-study-finds
#12
Susan Mayor
No abstract text is available yet for this article.
February 23, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28214250/colorectal-cancer-screening-adherence-in-selected-disabilities-over-10-years
#13
Chelsea B Deroche, Suzanne W McDermott, Joshua R Mann, James W Hardin
INTRODUCTION: Colorectal cancer (CRC) is the second leading cause of cancer mortality in the U.S.; however, if the population aged 50 years or older received routine screening, approximately 60% of these deaths could be eliminated. This study investigates whether adults, aged 50-75 years, with one of three disabilities (blind/low vision [BLV], intellectual disability [ID], spinal cord injury [SCI]) receive CRC screening at rates equivalent to adults without the three disabilities, by accounting for combinations of recommended CRC screenings during a 10-year period (colonoscopy, sigmoidoscopy, fecal occult blood test)...
February 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28155091/epi-procolon-%C3%A2-2-0-ce-a-blood-based-screening-test-for-colorectal-cancer
#14
Yvette N Lamb, Sohita Dhillon
Epi proColon(®) 2.0 CE is a blood-based test designed to aid in the early detection of colorectal cancer. The test comprises a qualitative assay for the polymerase chain reaction (PCR) detection of methylated Septin9 DNA, the presence of which is associated with colorectal cancer: however, positive results should be verified by colonoscopy or sigmoidoscopy. Epi proColon(®) 2.0 CE discriminated between patients with colorectal cancer and healthy controls with high clinical sensitivity and specificity in pivotal case-control studies...
April 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28148540/acute-lower-gi-bleeding-in-the-uk-patient-characteristics-interventions-and-outcomes-in-the-first-nationwide-audit
#15
Kathryn Oakland, Richard Guy, Raman Uberoi, Rachel Hogg, Neil Mortensen, Michael F Murphy, Vipul Jairath
OBJECTIVE: Lower GI bleeding (LGIB) is a common reason for emergency hospital admission, although there is paucity of data on presentations, interventions and outcomes. In this nationwide UK audit, we describe patient characteristics, interventions including endoscopy, radiology and surgery as well as clinical outcomes. DESIGN: Multicentre audit of adults presenting with LGIB to UK hospitals over 2 months in 2015. Consecutive cases were prospectively enrolled by clinical teams and followed for 28 days...
February 1, 2017: Gut
https://www.readbyqxmd.com/read/28143522/aspirin-intervention-for-the-reduction-of-colorectal-cancer-risk-aspired-a-study-protocol-for-a-randomized-controlled-trial
#16
David A Drew, Samantha M Chin, Katherine K Gilpin, Melanie Parziale, Emily Pond, Madeline M Schuck, Kathleen Stewart, Meaghan Flagg, Crystal A Rawlings, Vadim Backman, Peter J Carolan, Daniel C Chung, Francis P Colizzo, Matthew Freedman, Manish Gala, John J Garber, Curtis Huttenhower, Dmitriy Kedrin, Hamed Khalili, Douglas S Kwon, Sanford D Markowitz, Ginger L Milne, Norman S Nishioka, James M Richter, Hemant K Roy, Kyle Staller, Molin Wang, Andrew T Chan
BACKGROUND: Although aspirin is recommended for the prevention of colorectal cancer, the specific individuals for whom the benefits outweigh the risks are not clearly defined. Moreover, the precise mechanisms by which aspirin reduces the risk of cancer are unclear. We recently launched the ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED) trial to address these uncertainties. METHODS/DESIGN: ASPIRED is a prospective, double-blind, multidose, placebo-controlled, biomarker clinical trial of aspirin use in individuals previously diagnosed with colorectal adenoma...
February 1, 2017: Trials
https://www.readbyqxmd.com/read/28137903/subcorneal-pustular-dermatosis-and-episcleritis-associated-with-poorly-controlled-ulcerative-colitis
#17
Jeffrey J Wargo, Megan Adams, Julian Trevino
A man aged 56 years with a history of ulcerative colitis (UC) status postsubtotal colectomy was hospitalised with fevers, dry cough, eye redness and a new bloody, mucoid rectal discharge. 2 months prior to admission, the dermatologist had started him on dapsone for subcorneal pustular dermatosis but did not recognise that he had recently self-discontinued mesalamine enemas, inducing a flare of his UC. After a thorough inpatient evaluation, including flexible sigmoidoscopy, active UC involving the rectal stump was determined to be driving his dermatological and ophthalmological findings...
January 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28117881/comparative-effectiveness-of-screening-strategies-for-colorectal-cancer
#18
Afsaneh Barzi, Heinz-Josef Lenz, David I Quinn, Sarmad Sadeghi
BACKGROUND: Screening for colorectal cancer (CRC) has been successful in decreasing the incidence and mortality from CRC. Although new screening tests have become available, their relative impact on CRC outcomes remains unexplored. This study compares the outcomes of various screening strategies on CRC outcomes. METHODS: A Markov model representing the natural history of CRC was built and validated against empiric data from screening trials as well as the Microstimulation Screening Analysis (MISCAN) model...
January 24, 2017: Cancer
https://www.readbyqxmd.com/read/28111691/colorectal-cancer-screening
#19
Pak Wo Webber Chan, Jing Hieng Ngu, Zhongxian Poh, Roy Soetikno
Colorectal cancer, which is the leading cancer in Singapore, can be prevented by increased use of screening and polypectomy. A range of screening strategies such as stool-based tests, flexible sigmoidoscopy, colonoscopy and computed tomography colonography are available, each with different strengths and limitations. Primary care physicians should discuss appropriate screening modalities with their patients, tailored to their individual needs. Physicians, patients and the government should work in partnership to improve uptake of colorectal cancer screening to reduce the morbidity and mortality from colorectal cancer...
January 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28108788/outpatient-application-of-formalin-for-chronic-rectal-bleeding-after-prostate-irradiation-a-quasi-experimental-study
#20
Gustavo Arruda Viani, Aline Sakamoto
PURPOSE: The aim of this quasi-experimental study is to evaluate a novel technique for an outpatient application of formalin for chronic rectal bleeding after prostate irradiation. METHODS: This is a quasi- experimental clinical trial developed between January 2010 and July 2015, including 35 patients with chronic radiation rectitis (CRP) due to a previous prostate radiation course. The study's eligibility was (1) completed external beam radiation therapy for prostate carcinoma >6 months previously, (2) rectal bleeding, defined as a frequency of >1× per week and/or needing of blood transfusions, and (3) diagnosis of chronic proctitis at colonoscopy...
January 20, 2017: International Journal of Colorectal Disease
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