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https://www.readbyqxmd.com/read/28648086/lower-morbidity-and-improved-outcomes-in-patients-with-screen-detected-colorectal-cancer
#1
David Mansouri
Screening for colorectal cancer is now integrated into the fabric of healthcare systems across the world, as a wealth of evidence exists as regards its benefits in reducing cancer-specific mortality through the detection of early-stage disease. Options for screening include both endoscopic and stool-based tests, with a majority of countries opting for repeated faecal occult blood screening tests (FOBt). These can be either guaiac-based, as is the current system across the UK, or immunoglobulin-based, as is the case in the accompanying article from Spain...
June 26, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28626067/the-impact-of-a-population-based-screening-program-on-income-and-immigration-related-disparities-in-colorectal-cancer-screening
#2
Tara Kiran, Richard H Glazier, Rahim Moineddin, Sumei Gu, Andrew S Wilton, Lawrence Paszat
A population-based program promoting the Fecal Occult Blood Test (FOBT) for colorectal cancer screening was introduced in 2008 in Ontario, Canada, where opportunistic screening with colonoscopy had been increasing in frequency. We evaluated the impact of the program on income and immigration-related disparities in screening. We used linked administrative data to calculate colorectal cancer screening rates for eligible Ontarians in each year between 2001/02 (n=2,852,619) and 2013/14 (n=4,139,304). We quantified disparities using an "inequality ratio" of screening rates in the most disadvantaged group relative to the most advantaged group...
June 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28614895/endocuff-assisted-vs-standard-colonoscopy-in-the-fecal-occult-blood-test-based-uk-bowel-cancer-screening-programme-e-cap-study-a-randomized-trial
#3
Rupam Bhattacharyya, Fergus Chedgy, Kesavan Kandiah, Carole Fogg, Bernard Higgins, Ben Haysom-Newport, Lisa Gadeke, Fergus Thursby-Pelham, Richard Ellis, Patrick Goggin, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims Up to 25 % colorectal adenomas are missed during colonoscopy. The aim of this study was to investigate whether the endocuff could improve polyp detection in an organized bowel cancer screening program (BCSP). Patients and methods This parallel group, single-blinded, randomized controlled trial included patients with positive fecal occult blood test (FOBT) who were attending for BCSP colonoscopy. The primary outcome was the number of polyps per patient. Secondary outcomes included the number of adenomas per patient, adenoma and polyp detection rates, and withdrawal times...
June 14, 2017: Endoscopy
https://www.readbyqxmd.com/read/28584248/fecal-occult-blood-test-results-of-the-national-colorectal-cancer-screening-program-in-south-korea-2006-2013
#4
John Hoon Rim, Taemi Youk, Jung Gu Kang, Byung Kyu Park, Heon Yung Gee, Jeong-Ho Kim, Jongha Yoo
There has been controversy regarding the clinical utility of fecal occult blood test (FOBT) as a screening tool for colorectal cancer (CRC) in the general population. The purpose of this study was to examine the results of Korea national CRC screening using FOBT from 2006 to 2013 and to evaluate the implementation of the program. We analyzed the results of FOBT, colonoscopy, and the side effects during colonoscopy for the subjects (n = 20,609,909) from the Korea National Health Insurance Cancer Screening database...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28572616/comparison-of-non-invasive-biomarkers-faecal-baff-calprotectin-and-fobt-in-discriminating-ibs-from-ibd-and-evaluation-of-intestinal-inflammation
#5
Yu Fu, Lingli Wang, Cheng Xie, Kaifang Zou, Lei Tu, Wei Yan, Xiaohua Hou
Faecal calprotectin and faecal occult blood test (FOBT) were widely used in the diagnosis and assessment of intestinal inflammation in inflammatory bowel disease (IBD). Recently we identified an excellent new biomarker B cell-activating factor (BAFF) for IBD. Here in this study we compared the efficacy of faecal BAFF, calprotectin and FOBT to find the "best non-invasive marker". Results showed that for discriminating IBD from IBS, BAFF ≥227.3 pg/ml yield 84% sensitivity, 100% specificity, 100% positive predictive value (PPV) and 64% negative predictive value (NPV) while calprotectin ≥50 µg/g yield 76% sensitivity, 93% specificity, 97% PPV and 53% NPV...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494531/stages-of-adoption-for-fobt-and-colonoscopy-tests-for-colorectal-cancer-screening-in-korea
#6
Nhung Bui Cam, Hana Cho, Yoon Young Lee, Mina Suh, Boyoung Park, Jae Kwan Jun, Yeol Kim, Kui Son Choi
Purpose: While colorectal cancer (CRC) is common in Asian countries, screening for CRC is not. Moreover, CRC screening behaviors in Asian populations remain largely unknown. The present study aimed to investigate the stages of adopting CRC screening in Korea according to screening modality. Materials and Methods: Data were obtained from the 2014 Korean National Cancer Screening Survey, a cross-sectional survey that utilized nationally representative random sampling to investigate cancer screening rates...
May 10, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28493543/contribution-of-patient-physician-and-environmental-factors-to-demographic-and-health-variation-in-colonoscopy-follow-up-for-abnormal-colorectal-cancer-screening-test-results
#7
Melissa R Partin, Amy A Gravely, James F Burgess, David A Haggstrom, Sarah E Lillie, David B Nelson, Sean M Nugent, Aasma Shaukat, Shahnaz Sultan, Louise C Walter, Diana J Burgess
BACKGROUND: Patient, physician, and environmental factors were identified, and the authors examined the contribution of these factors to demographic and health variation in colonoscopy follow-up after a positive fecal occult blood test/fecal immunochemical test (FOBT/FIT) screening. METHODS: In total, 76,243 FOBT/FIT-positive patients were identified from 120 Veterans Health Administration (VHA) facilities between August 16, 2009 and March 20, 2011 and were followed for 6 months...
May 11, 2017: Cancer
https://www.readbyqxmd.com/read/28490420/testing-the-effectiveness-of-a-primary-care-intervention-to-improve-uptake-of-colorectal-cancer-screening-a-randomized-controlled-trial-protocol
#8
Natalie Dodd, Mariko Leanne Carey, Elise Mansfield, Christopher Oldmeadow
BACKGROUND: Screening for colorectal cancer (CRC) significantly reduces mortality associated with this disease. In Australia, the National Bowel Cancer Screening Program provides regular fecal occult blood tests (FOBT) for those aged 50 to 74 years, however, participation rates in the program have plateaued at 36%. Given low uptake in the National Bowel Cancer Screening Program, it is necessary to explore alternate methods to increase CRC screening rates. Primary care is a promising adjunct setting to test methods to increase CRC screening participation...
May 10, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28475117/a-label-free-quantitative-fecal-hemoglobin-detection-platform-for-colorectal-cancer-screening
#9
Gita V Soraya, Thanh C Nguyen, Chathurika D Abeyrathne, Duc H Huynh, Jianxiong Chan, Phuong D Nguyen, Babak Nasr, Gursharan Chana, Patrick Kwan, Efstratios Skafidas
The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings...
May 5, 2017: Biosensors
https://www.readbyqxmd.com/read/28469908/measuring-and-improving-cervical-breast-and-colorectal-cancer-screening-rates-in-a-multi-site-urban-practice-in-toronto-canada
#10
Joshua Feldman, Sam Davie, Tara Kiran
Our Family Health Team is located in Toronto, Canada and provides care to over 35 000 patients. Like many practices in Canada, we took an opportunistic approach to cervical, breast, and colorectal cancer screening. We wanted to shift to a proactive, population-based approach but were unable to systematically identify patients overdue for screening or calculate baseline screening rates. Our initiative had two goals: (1) to develop a method for systematically identifying patients eligible for screening and whether they were overdue and (2) to increase screening rates for cervical, breast, and colorectal cancer...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28464181/utility-of-hemoccult-testing-before-therapeutic-anticoagulation-in-venous-thromboembolism
#11
Ryan Urbas, Marwan Badri, Nicole E Albert, Catherine Prince, Barani Mayilvaganan
OBJECTIVES: Fecal occult blood testing (FOBT) is performed routinely before starting therapeutic anticoagulation in patients despite it never being validated to predict gastrointestinal bleeding (GIB) risk. Our objective was to determine the utility in checking the guaiac FOBT test (gFOBT) before initiating therapeutic anticoagulation in patients with a new diagnosis of venous thromboembolism (VTE). METHODS: This was a retrospective chart review that examined patients with a diagnosis of VTE admitted during a 2-year period in one mid-sized tertiary care center...
May 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28463410/long-term-risk-of-colorectal-cancer-after-negative-colonoscopy-in-a-danish-gfobt-screening-cohort
#12
Andreas Bjerrum, Ole Andersen, Anders Fischer, Jan Lindebjerg, Elsebeth Lynge
Faecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all screen positive persons have negative colonoscopy, but consensus is lacking on how these persons should be followed up. Health authorities in Denmark and The Netherlands recommend suspending screening for 8-10 years, while patients in UK are invited to screening after 2 years. In this cohort-study, we followed 166,277 individuals invited to FOBT-screening in 2005-2006 and a reference group comprising the remaining 1,240,348 Danes of the same age...
April 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28447326/ct-colonography-role-in-fobt-based-screening-programs-for-colorectal-cancer
#13
REVIEW
Lapo Sali, Grazia Grazzini, Mario Mascalchi
Computed tomographic colonography (CTC) is a minimally invasive imaging examination for the colon, and is safe, well tolerated and accurate for the detection of colorectal cancer (CRC) and advanced adenoma. While the role of CTC as a primary test for population screening of CRC is under investigation, the fecal occult blood test (FOBT) has been recommended for population screening of CRC in Europe. Subjects with positive FOBT are invited to undergo total colonoscopy, which has some critical issues, such as suboptimal compliance, contraindications and the possibility of an incomplete exploration of the colon...
April 26, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28368949/uptake-of-a-colorectal-cancer-screening-blood-test-in-people-with-elevated-risk-for-cancer-who-cannot-or-will-not-complete-a-faecal-occult-blood-test
#14
Erin L Symonds, Charles Cock, Rosie Meng, Stephen R Cole, Robert J L Fraser, Graeme P Young
Participation rates in colorectal cancer (CRC) screening programmes using faecal occult blood tests (FOBTs) are low. Nonparticipation is commonly attributed to psychosocial factors, but some medical conditions also prevent screening. These barriers might be partially overcome if a blood test for CRC screening was available. This study determined whether people who had always declined screening by FOBT would participate if offered a blood test. An audit of registrants within a personalized CRC screening programme was undertaken to determine the reasons for regular nonparticipation in FOBT...
March 31, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28344855/changes-in-colorectal-cancer-screening-knowledge-behavior-beliefs-self-efficacy-and-barriers-among-community-health-clinic-patients-after-a-health-literacy-intervention
#15
Connie L Arnold, Alfred Rademaker, Dachao Liu, Terry C Davis
OBJECTIVE: The objective in this pre- and post-survey assessment was to compare the effectiveness of a health literacy-directed intervention designed to increase knowledge, beliefs, barriers, self-efficacy and behavior associated with CRC screening with FOBT among patients cared for in predominantly rural community clinics and the change in these characteristics over the first 15 months after enrolling in a study designed to assess screening strategies. METHODS: Between 2008 and 2011, a quasi-experimental intervention was conducted in 8 predominantly rural Federally Qualified Health Centers...
February 2017: Journal of Community Medicine & Health Education
https://www.readbyqxmd.com/read/28298185/general-practitioners-perceptions-of-population-based-bowel-screening-and-their-influence-on-practice-a-qualitative-study
#16
Greer Dawson, Melanie Crane, Claudine Lyons, Anna Burnham, Tara Bowman, Donna Perez, Joanne Travaglia
BACKGROUND: Although largely preventable, Australia has one of the highest rates of bowel cancer in the world. General Practitioners (GPs) have an important role to play in prevention and early detection of bowel cancer, however in Australia this is yet to be optimised and participation remains low. This study sought to understand how GPs' perceptions of bowel screening influence their attitudes to, and promotion of the faecal occult blood test (FOBT), to identify opportunities to enhance their role...
March 15, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28289733/correcting-for-microbial-blooms-in-fecal-samples-during-room-temperature-shipping
#17
Amnon Amir, Daniel McDonald, Jose A Navas-Molina, Justine Debelius, James T Morton, Embriette Hyde, Adam Robbins-Pianka, Rob Knight
The use of sterile swabs is a convenient and common way to collect microbiome samples, and many studies have shown that the effects of room-temperature storage are smaller than physiologically relevant differences between subjects. However, several bacterial taxa, notably members of the class Gammaproteobacteria, grow at room temperature, sometimes confusing microbiome results, particularly when stability is assumed. Although comparative benchmarking has shown that several preservation methods, including the use of 95% ethanol, fecal occult blood test (FOBT) and FTA cards, and Omnigene-GUT kits, reduce changes in taxon abundance during room-temperature storage, these techniques all have drawbacks and cannot be applied retrospectively to samples that have already been collected...
March 2017: MSystems
https://www.readbyqxmd.com/read/28282604/the-fecal-occult-blood-test-as-a-tool-for-improved-outpatient-qualification-for-colonoscopy-a-single-center-experience-and-10-year-follow-up-survey
#18
Zbigniew Banaszkiewicz, Jacek Budzyński, Krzysztof Tojek, Paweł Jarmocik, Jacek Frasz, Marcin Mrozowski, Maciej Świtoński, Arkadiusz Jawień
PURPOSE: Colonoscopy is not widely and easily available in all countries, even for symptomatic patients. This is one of the causes of tumors not being diagnosed until an advanced stage. The aim of this study was to estimate the efficacy of the fecal occult blood test (FOBT) in the diagnostic work-up of outpatients referred to a colorectal unit due to indistinct abdominal symptoms. PATIENTS/METHODS: Among 10418 consecutive symptomatic individuals referred to the outpatient clinic, an immunochemical FOBT (Hem-Check 1(®)) was recommended for 9432 patients with indistinct symptoms as a tool for qualifying them for colonoscopy...
March 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28277021/the-chinese-and-korean-american-immigrant-experience-a-mixed-methods-examination-of-facilitators-and-barriers-of-colorectal-cancer-screening
#19
Mary Y Jung, Cheryl L Holt, Diane Ng, Hwa J Sim, Xiaoxiao Lu, Daisy Le, Hee-Soon Juon, Jun Li, Sunmin Lee
OBJECTIVE: Among Asian Americans, colorectal cancer (CRC) is the second leading cause of cancer deaths. Despite strong evidence that screening can reduce CRC-related mortality, fewer Chinese and Koreans receive screening as compared to non-Hispanic whites and blacks. The objective of this study was to examine facilitators and barriers as well as strategies to promote CRC screening in this population. DESIGN: This study employed a mixed-methods design. We conducted 17 key informant interviews and 12 focus groups in the Washington, D...
February 25, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28270725/a-centrally-generated-primary-care-physician-audit-report-does-not-improve-colonoscopy-uptake-after-a-positive-result-on-a-fecal-occult-blood-test-in-ontario-s-coloncancercheck-program
#20
D Stock, L Rabeneck, N N Baxter, L F Paszat, R Sutradhar, L Yun, J Tinmouth
BACKGROUND: Timely follow-up of fecal occult blood screening with colonoscopy is essential for achieving colorectal cancer mortality reduction. In the present study, we evaluated the effectiveness of centrally generated, physician-targeted audit and feedback to improve colonoscopy uptake after a positive fecal occult blood test (fobt) result within Ontario's population-wide ColonCancerCheck Program. METHODS: This prospective cohort study used data sets from Ontario's ColonCancerCheck Program (2008-2011) that were linked to provincial administrative health databases...
February 2017: Current Oncology
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