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https://www.readbyqxmd.com/read/29739056/development-of-a-combined-human-transferrin-hemoglobin-lateral-immunochromatographic-assay-for-accurate-and-rapid-fecal-occult-blood-test
#1
Yuanyuan Ye, Yin Deng, Jinju Mao, Qin Yan, Yidan Huang, Jun Zhang, Jian Zheng, Yue Li, Weixian Chen
BACKGROUND: Fecal occult bloodtest (FOBT) plays an important role in the diagnosis of gastrointestinal diseases. The sensitivities of current FOBT methods are still not satisfactory. The aim of this study is to develop a combined human transferrin (HTf)-hemoglobin (HHb) lateral flow assay (LFA) for accurate and rapid FOBT. METHODS: Monoclonal antibodies (MAbs) targeting HTf were developed by conventional methods and paired using LFA strips. The best HTf MAb pair was chosen according to the overall performance on testing limit and specificity...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29643290/-screening-for-colorectal-cancer-using-immunological-fecal-occult-blood-test-in-inpatients
#2
Hideaki Kawabata, Naonori Inoue, Yukino Kawakatsu, Yuji Okazaki, Misuzu Hitomi, Masatoshi Miyata, Shigehiro Motoi
We investigated the usefulness of screening for colorectal cancer (CRC) using immunological fecal occult blood test (FOBT) in 472 scheduled inpatients (median age, 68.6 years) who underwent screening for CRC via FOBT (single stool sample) at our hospital. The recall rate for further examination was 26.6% (126/472), and the rate of patients who underwent further examination was only 34.9% (44/126). The overall colorectal neoplasm detection rate, overall CRC detection rate, and positive predictive value for CRC in inpatients were 5...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29626451/effectiveness-of-colorectal-cancer-screening-in-detecting-earlier-stage-disease-a-nationwide-cohort-study-in-denmark
#3
Mette Bach Larsen, Sisse Njor, Peter Ingeholm, Berit Andersen
BACKGROUND & AIMS: Most studies of the effectiveness of screening for colorectal cancer (CRC) using the fecal occult blood test (FOBT) tested the guaiac FOBT. However, the fecal immunochemical test (FIT) is now commonly used in screening. We aimed to evaluate the effects of FIT-based screening for CRC on the number of incident CRC diagnoses and stage at diagnosis for individuals in Denmark who were invited for screening vs not invited. METHODS: We collected data from a register-based retrospective cohort study during the first 16 months of the prevalence round of a FIT-based CRC screening program (March 1, 2014 through June 30, 2015)...
April 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29626277/evaluation-of-fecal-m2pk-as-a-diagnostic-marker-in-colorectal-cancer
#4
Hisham K Dabbous, Yosry Abd El-Rahman Mohamed, Runia F El-Folly, Mohamed D El-Talkawy, Hani E Seddik, Dina Johar, Mohammed A Sarhan
BACKGROUND: Invasive colonoscopy is the gold standard for patients at risk for colorectal cancer. However, the need for non-invasive and specific markers is required. OBJECTIVE: To evaluate the sensitivity of the glycolytic pyruvate kinase isoenzyme type M2 dimer (M2PK) as a diagnostic biomarker for colorectal cancer (CRC) and adenomatous colorectal polyps (CRP) screening. DESIGN: Case-control. PATIENTS: Twenty patients with CRC, 20 patients with CRP (lack criteria for colonic cancer by biopsy), and 20 normal subjects...
April 7, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29603075/promoting-colorectal-cancer-screening-in-foreign-born-chinese-american-women-does-racial-ethnic-and-language-concordance-matter
#5
Karen Kim, Michal Quinn, Helen Lam
Chinese Americans are one of the fastest-growing and largest Asian-American subgroups. Approximately 70% of Chinese Americans are immigrants with 46% being of limited English proficiency. Despite colorectal cancer (CRC) being the second leading cause of cancer death in Chinese Americans, Chinese Americans have lower CRC screening rates than other Asian subgroups, and only 40% of CRC cases among Chinese Americans are diagnosed early. Furthermore, CRC is the second most common cancer among Chinese American women...
March 30, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29578594/a-physician-initiated-intervention-to-increase-colorectal-cancer-screening-in-chinese-patients
#6
Angela Sun, Janice Y Tsoh, Elisa K Tong, Joyce Cheng, Edward A Chow, Susan L Stewart, Tung T Nguyen
BACKGROUND: Among Chinese American individuals, only approximately 42% of cases of colorectal cancer (CRC) are diagnosed at an early stage, possibly because these patients are less likely than non-Hispanic white individuals to undergo CRC screening. METHODS: Primary care physicians (PCPs) were recruited from a local independent practice association serving Chinese Americans and randomized into early-intervention and delayed-intervention groups. PCPs in the early-intervention group received continuing medical education (CME), and their patients received an intervention mailer, consisting of a letter with the PCP's recommendation, a bilingual educational booklet, and a fecal occult blood test (FOBT) kit in year 1...
April 1, 2018: Cancer
https://www.readbyqxmd.com/read/29528551/prevalence-of-appropriate-colorectal-cancer-screening-and-preferences-for-receiving-screening-advice-among-people-attending-outpatient-clinics
#7
Natalie Dodd, Elise Mansfield, Mariko Carey, Christopher Oldmeadow
OBJECTIVE: To examine among people attending outpatient clinics aged 50-74 at average risk of colorectal cancer (CRC): 1) The proportion who report: a) faecal occult blood test (FOBT) within the past two years; and b) colonoscopy within the past five years, including the reasons for undergoing colonoscopy; 2) characteristics associated with under-screening; 3) For those who are under-screened, the proportion who are: a) willing to receive help and the acceptability of different methods of receiving help, and; b) unwilling to receive help and reasons for this...
March 12, 2018: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29487413/patterns-and-predictors-of-repeat-fecal-immunochemical-and-occult-blood-test-screening-in-four-large-health-care-systems-in-the-united-states
#8
Amit G Singal, Douglas A Corley, Aruna Kamineni, Michael Garcia, Yingye Zheng, Paul V Doria-Rose, Virginia P Quinn, Christopher D Jensen, Jessica Chubak, Jasmin Tiro, Chyke A Doubeni, Nirupa R Ghai, Celette Sugg Skinner, Karen Wernli, Ethan A Halm
OBJECTIVES: Effectiveness of fecal occult blood test (FOBT) for colorectal cancer (CRC) screening depends on annual testing, but little is known about patterns of repeat stool-based screening within different settings. Our study's objective was to characterize screening patterns and identify factors associated with repeat screening among patients who completed an index guaiac FOBT (gFOBT) or fecal immunochemical test (FIT). METHODS: We performed a multi-center retrospective cohort study among people who completed a FOBT between January 2010 and December 2011 to characterize repeat screening patterns over the subsequent 3 years...
February 27, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29465743/participation-in-bowel-screening-among-men-attending-abdominal-aortic-aneurysm-screening
#9
A J Quyn, C G Fraser, J Rodger, A Digan, A S Anderson, R J C Steele
BACKGROUND: Uptake of population-based screening for colorectal cancer in Scotland is around 55 per cent. Abdominal aortic aneurysm (AAA) screening has recently been introduced for men aged 65 years and the reported uptake is 78 per cent. The aim was to determine the impact of a brief intervention on bowel screening in men who attended AAA screening, but previously failed to complete bowel screening. METHODS: Men invited for AAA screening between September 2015 and March 2016 within NHS Tayside were included...
April 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29410020/impact-of-2-generational-improvements-in-colonoscopes-on-adenoma-miss-rates-results-of-a-prospective-randomized-multicenter-tandem-study
#10
Mathieu Pioche, Angélique Denis, Hans-Dieter Allescher, Gianluca Andrisani, Guido Costamagna, Evelien Dekker, Paul Fockens, Christian Gerges, Stefan Groth, Jennis Kandler, Isabelle Lienhart, Horst Neuhaus, Lucio Petruzziello, Guido Schachschal, Kristien Tytgat, Jürgen Wallner, Vincens Weingart, Sandrine Touzet, Thierry Ponchon, Thomas Rösch
BACKGROUND AND AIMS: Numerous randomized studies have shown that changing certain features of colonoscopes, usually incorporated when switching from one endoscope generation to the next, mostly do not increase adenoma yield. There is, however, indirect evidence that it may be necessary to skip one instrument generation (ie, changing from one generation to the next but one) to achieve this effect. METHODS: We compared the latest-generation colonoscopes from one company (Olympus Exera III, 190-C) with the next to last one (Olympus 160/5-C) in a prospective multicenter study randomized for the order of colonoscopes in a tandem fashion, involving 2 different examiners...
February 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29368418/ileo-colonic-neuroendocrine-tumours-identified-in-the-english-bowel-cancer-screening-programme-bcsp
#11
R Basuroy, C M O'Donnell, R Srirajaskanthan, J K Ramage
AIMS: Ileocolonic neuroendocrine tumours (NETs) are diagnosed as part of bowel cancer screening programmes (BCSP). The aim of this study was to identify and characterise NETs diagnosed within the English BCSP, a double screen programme using guaic faecal occult blood (FOBT) screening and colonoscopy, by interrogating the national colorectal screening database and validating the findings with individual BCSP centers. METHODS: The Exeter database was interrogated by running queries to identify participants with coded NETs (2006-2014)...
January 25, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29363535/improved-adenoma-detection-with-endocuff-vision-the-adenoma-randomised-controlled-trial
#12
Wee Sing Ngu, Roisin Bevan, Zacharias P Tsiamoulos, Paul Bassett, Zoë Hoare, Matthew D Rutter, Gayle Clifford, Nicola Totton, Thomas J Lee, Arvind Ramadas, John G Silcock, John Painter, Laura J Neilson, Brian P Saunders, Colin J Rees
OBJECTIVE: Low adenoma detection rates (ADR) are linked to increased postcolonoscopy colorectal cancer rates and reduced cancer survival. Devices to enhance mucosal visualisation such as Endocuff Vision (EV) may improve ADR. This multicentre randomised controlled trial compared ADR between EV-assisted colonoscopy (EAC) and standard colonoscopy (SC). DESIGN: Patients referred because of symptoms, surveillance or following a positive faecal occult blood test (FOBt) as part of the Bowel Cancer Screening Programme were recruited from seven hospitals...
January 23, 2018: Gut
https://www.readbyqxmd.com/read/29358889/systematic-review-of-colorectal-cancer-screening-guidelines-for-average-risk-adults-summarizing-the-current-global-recommendations
#13
Florence Bénard, Alan N Barkun, Myriam Martel, Daniel von Renteln
AIM: To summarize and compare worldwide colorectal cancer (CRC) screening recommendations in order to identify similarities and disparities. METHODS: A systematic literature search was performed using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of National Gastroenterology Society websites, the National Guideline Clearinghouse, the BMJ Clinical Evidence website, Google and Google Scholar was performed...
January 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29324557/factors-influencing-participation-in-fecal-occult-blood-testing-to-screen-for-colorectal-cancer-in-australia-a-scoping-review-protocol
#14
Simone Lee, Andrea Miller
The objective of this scoping review is to examine and map the evidence on the range of factors influencing a person's decision to screen or not screen for colorectal cancer using a fecal occult blood test (FOBT) in Australia, with the view to identifying gaps in the research and informing appropriate questions for future systematic reviews.The question of this review is: what evidence is available around the barriers and facilitators that influence an individual's decision to screen or not screen for colorectal cancer using a fecal occult blood test in Australia?...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29304835/a-systematic-review-of-clinic-and-community-intervention-to-increase-fecal-testing-for-colorectal-cancer-in-rural-and-low-income-populations-in-the-united-states-how-what-and-when
#15
Melinda M Davis, Michele Freeman, Jackilen Shannon, Gloria D Coronado, Kurt C Stange, Jeanne-Marie Guise, Stephanie B Wheeler, David I Buckley
BACKGROUND: Interventions to improve fecal testing for colorectal cancer (CRC) exist, but are not yet routine practice. We conducted this systematic review to determine how implementation strategies and contextual factors influenced the uptake of interventions to increase Fecal Immunochemical Tests (FIT) and Fecal Occult Blood Testing (FOBT) for CRC in rural and low-income populations in the United States. METHODS: We searched Medline and the Cochrane Library from January 1998 through July 2016, and Scopus and clinicaltrials...
January 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29283904/role-of-full-spectrum-endoscopy-in-colorectal-cancer-screening-randomized-trial
#16
Henar Núñez-Rodríguez, Pilar Diez-Redondo, Manuel Pérez-Miranda, Manuel Gonzalez Sagrado, Rosa Conde, Carlos De la Serna
GOALS: The aim of this study was to compare a new, full-spectrum endoscope (Fuse; EndoChoice, Alpharetta, GA) to standard forward-viewing colonoscopy in the detection of colorectal neoplasms. BACKGROUND: Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22% to 28% of polyps, increasing the risk of interval cancer. Endoscopic improvement of the adenoma detection rate decrease interval carcinomas. Full-spectrum endoscopy (FUSE) (330-degree field of view), in a tandem study, has been shown to reduce the adenoma miss rate...
December 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29281865/cancer-screening-awareness-and-practice-in-a-middle-income-country-a-systematic-review-from-iran
#17
Azam Majidi, Somayye Majidi, Somayye Salimzadeh, Maryam Khazaee- Pool, Alireza Sadjadi, Hamideh Salimzadeh, Alireza Delavari
Objective: Ageing population and noticeable changes in lifestyle in developing countries like Iran caused an increase in cancer incidence. This requires organized cancer prevention and screening programs in population level, but most importantly community should be aware of these programs and willing to use them. This study explored existing evidence on public awareness and practice, as well as, adherence to cancer screening in Iranian population. Methods: Major English databases including Web of Science, PubMed, Scopus, and domestic Persian databases i...
December 28, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29246126/perceptions-of-colorectal-cancer-screening-and-recommendation-behaviors-among-physicians-in-korea
#18
Hye Young Shin, Mina Suh, Boyoung Park, Jae Kwan Jun, Kui Son Choi
BACKGROUND: Physician recommendations for colorectal cancer (CRC) screening have consistently been shown to be a strong predictor of screening. The aim of this study was to investigate perceptions of CRC screening modalities and recommendation behaviors among physicians in Korea. METHODS: A cross-sectional, nationally representative survey conducted between November 2013 and February 2014. In total, 379 physicians (241 primary care physicians and 138 physicians affiliated with the Korean Association for the Study of Intestinal Diseases responded to this survey (overall response rate of 31...
December 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29239679/primary-care-variability-in-patients-at-higher-risk-for-colorectal-cancer-evaluation-of-screening-and-preventive-care-practices
#19
John Peabody, Juan-Sebastien Saldivar, Eric Swagel, Steven Fugaro, David Paculdo, Mary Tran
OBJECTIVE: Sub-optimal colorectal cancer (CRC) evaluations have been attributed to both physician and patient factors. The primary objective of this study was to evaluate physician practice variation in patients with a higher risk of CRC. We wanted to identify the physician characteristics and the types of patients that were associated with missed screening opportunities; we also explored whether screening for CRC served as a proxy for better preventive care practices. METHODS: A total of 213 board-certified family and internal medicine physicians participated in the study, conducted between September and December 2016...
January 21, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29197686/the-impact-of-screening-on-cancer-incidence-and-mortality-in-missouri-usa-2004-2013
#20
Y Yoshida, C L Schmaltz, J Jackson-Thompson, E J Simoes
OBJECTIVES: Population-based evidence regarding impact of cancer screenings and cancer rates in Missouri is lacking. This study examined whether screenings of breast cancer, cervical cancer, and colorectal cancer impact early-stage cancer incidence and mortality in Missouri. STUDY DESIGN: This is an ecological study based on county-specific estimates of selected cancer screening prevalence and early-stage cancer incidence and cancer mortality. METHODS: County-specific prevalence of clinical breast examination, mammography, Pap test, sigmoidoscopy or colonoscopy, and fecal occult blood test (FOBT) were generated from Missouri County-Level Study (2003, 2007, and 2011)...
January 2018: Public Health
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