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cutanous leishmaniasis

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https://www.readbyqxmd.com/read/28329481/cutaneous-leishmaniasis-mimicking-squamous-cell-carcinoma
#1
Tara Oetken, Bryan Hiscox, Ida Orengo, Theodore Rosen
A 41-year-old man from Cuero, Texas with a nonhealinglesion on his left cheek was referred to ourclinic for removal of a squamous cell carcinoma. Thepatient first noticed a "pimple" on his left cheek 3-4months prior to presentation. When the lesion beganto grow he presented to his primary care physician anda biopsy was taken, showing "atypical squamous cellproliferation." Mohs surgery was performed and thenodule was removed with no evidence of malignancyseen on histopathology. Upon review of the surgicalbiopsies by consulting pathologists, the diagnosis ofleishmaniasis was established and later confirmed bythe Center for Disease Control and Prevention (CDC)as Leishmania mexicana...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327803/serodiagnosis-of-visceral-and-cutaneous-leishmaniasis-in-human-and-canine-populations-living-in-indigenous-reserves-in-the-brazilian-amazon-region
#2
Julia Teresa Ribeiro de Lima, Solange Maria Gennari, Herbert Sousa Soares, Antonio Humberto Hamad Minervino, Antonio Francisco Malheiros, Fernando Silveira Marques, Márcia Dalastra Laurenti, Rosangela Zacarias Machado, Arlei Marcili, Marcelo Bahia Labruna, Rodrigo Martins Soares
INTRODUCTION: Leishmaniasis is endemic to the Northern, Northeastern, Central-Western, and Southeastern regions of Brazil. We aimed to assess the epidemiological situation of leishmaniasis in humans and dogs in indigenous villages located in the States of Mato Grosso and Tocantins using a serological survey conducted in May 2011. METHODS: Serum samples were collected from 470 humans and 327 dogs living in villages of the Urubu Branco and Tapirapé Karajá indigenous reserves...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327802/in-vitro-and-in-vivo-antileishmanial-activity-of-artemisia-annua-l-leaf-powder-and-its-potential-usefulness-in-the-treatment-of-uncomplicated-cutaneous-leishmaniasis-in-humans
#3
Luz Estella Mesa, Daniel Vasquez, Pierre Lutgen, Iván Darío Vélez, Adriana María Restrepo, Isabel Ortiz, Sara María Robledo
INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of various diseases in 80% of the global population, the validation of these products is essential. Gelatin capsules containing dried Artemisia annua leaf powder were recently developed as a new herbal formulation (totum) for the oral treatment of malaria and other parasitic diseases...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327413/domestic-dogs-as-reservoir-hosts-for-leishmania-donovani-in-the-southernmost-western-ghats-in-india
#4
P Jambulingam, N Pradeep Kumar, S Nandakumar, K P Paily, R Srinivasan
The peripheral blood samples from domestic dogs (n=47) and wild rats (n=25) in the Kani Tribe settlements, located southernmost part of the Western Ghats, Thiruvananthapuram district, Kerala, India were examined for Leishmania infection. This area is known for cases of leishmaniasis with cutaneous manifestations and sandfly abundance. The tribes domesticate dogs to protect them from untoward activities of wild animals. Leishmania donovani parasite DNA was detected only from 6.4% (n=3) of the blood samples collected from the domestic dogs by amplification of the diagnostic kinetoplast mini-circle DNA and PCR-RFLP analysis of the UTR region of heat shock protein 70 (hsp70) gene...
March 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28319012/the-expanding-world-of-human-leishmaniasis
#5
James A Cotton
New Leishmania isolates form a novel group of human parasites related to Leishmania enrietti, with cases in Ghana, Thailand, and Martinique; other relatives infect Australian and South American wildlife. These parasites apparently cause both cutaneous and visceral disease, and may have evolved a novel transmission mechanism exploiting blood-feeding midges.
March 16, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28316425/molecular-characterization-of-leishmania-parasites-isolated-from-sandflies-species-of-a-zoonotic-cutaneous-leishmaniasis-in-musiyan-south-west-iran
#6
Farzaneh Kavarizadeh, Shahram Khademvatan, Babak Vazirianzadeh, Mohammad Hossein Feizhaddad, Mehdi Zarean
Cutaneous leishmaniasis (CL) is vector borne parasitic disease, considered as public health problem especially in border of Iran and Iraq, Dehloran County (Musian district). The aim of this study was molecular identification of Leishmania parasites in sandfly as vectors of Leishmaniasis. Totally 280 female sandflies were trapped by sticky traps from 7 rural areas of Musiyan in September-November 2012. All sandflies were identified using morphological characters of the head and abdominal terminalia. DNA was extracted from female sandflies and Leishmania was identified using PCR and sequencing...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28316408/isolation-and-identification-of-cutaneous-leishmaniasis-species-by-pcr-rflp-in-ilam-province-the-west-of-iran
#7
Ali Kermanjani, Lame Akhlaghi, Hormozd Oormazdi, Ramtin Hadighi
Cutaneous leishmaniasis (CL) is one of the most common parasitic diseases and public health problems in Iran. CL is endemic in most parts of Ilam province, in the west of Iran. The distance from the center of country, the great number of divers rural areas, and lack of specialists and laboratory facilities have been the major causes of Leishmania species remaining unknown in this region. Polymerase chain reaction followed by restriction fragment length polymorphism was performed to identify the Leishmania species in 61 patients with cutaneous lesions...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28304356/spatially-correlated-time-series-and-ecological-niche-analysis-of-cutaneous-leishmaniasis-in-afghanistan
#8
Oyelola A Adegboye, Majeed Adegboye
Leishmaniasis is the third most common vector-borne disease and a very important protozoan infection. Cutaneous leishmaniasis is one of the most common types of leishmaniasis infectious diseases with up to 1.2 million occurrences of new cases each year worldwide. A dynamic transmission multivariate time series model was applied to the data to account for overdispersion and evaluate the effects of three environmental layers as well as seasonality in the data. Furthermore, ecological niche modeling was used to study the geographically suitable conditions for cutaneous leishmaniasis using temperature, precipitation and altitude as environmental layers, together with the leishmaniasis presence data...
March 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28301305/molecular-characterization-of-leishmania-parasites-in-giemsa-stained-slides-from-cases-of-human-cutaneous-and-visceral-leishmaniasis-eastern-algeria
#9
Nadia Beldi, Roukaya Mansouri, Jihene Bettaieb, Alia Yaacoub, Hejer Souguir Omrani, Yusr Saadi Ben Aoun, Farida Saadni, Ikram Guizani, Souheila Guerbouj
BACKGROUND: In Algeria, visceral leishmaniasis (VL) is due to Leishmania (L.) infantum, while three cutaneous forms (CL) are caused by Leishmania major, Leishmania tropica and Leishmania infantum. In this study, the use of Giemsa-stained slides was evaluated with two PCR techniques, in Eastern Algeria. MATERIALS AND METHODS: A total of 136 samples corresponding to 100 CL smears (skin scrapings) and 36 VL slides (bone marrow aspirates) collected from 2008 to 2014 were tested...
March 16, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28294400/chronic-amastigote-negative-cutaneous-leishmaniasis-a-clinical-histopathologic-and-molecular-study-of-27-cases-with-emphasis-on-atypical-and-pseudolymphomatous-presentations
#10
Carlo Tomasini, Laura Moneghini, Maria Barbui Anna
BACKGROUND: Chronic amastigote-negative cutaneous leishmaniasis (CL) is a diagnostic challenge, as the parasite load may be low, or absent in biopsy tissue sections. METHODS: A series of consecutive biopsy specimens, taken from 130 patients with a diagnosis of granulomatous dermatitis of unknown etiology, were reviewed. PCR was carried out for Leishmania-specific DNA. RESULTS: A total of 27/130 samples were positive for Leishmania-specific DNA...
March 10, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28289158/annexin-a1-is-involved-in-the-resolution-of-inflammatory-responses-during-leishmania-braziliensis-infection
#11
Leandro G Oliveira, Míriam C Souza-Testasicca, Juliana P Vago, Amanda Braga Figueiredo, Adriana M C Canavaci, Luiza Oliveira Perucci, Tatiana P Teixeira Ferreira, Eduardo A F Coelho, Denise Utsch Gonçalves, Manoel Otávio C Rocha, Patrícia M R E Silva, Cláudia N Ferreira, Celso Queiroz-Junior, Lirlândia P Sousa, Ana Paula Fernandes
Leishmaniases are diseases caused by several Leishmania species. Leishmania (Viannia) braziliensis can cause localized cutaneous leishmaniasis (LCL), which heals spontaneously, or mucosal leishmaniasis (ML), characterized by chronic and intense inflammation and scanty parasitism. Annexin A1 (AnxA1) is a protein involved in modulation and resolution of inflammation through multiple mechanisms. In the present study, the role of AnxA1 was investigated in L. braziliensis-infected BALB/c mice. AnxA1 levels increased at the peak of tissue lesion and parasitism in infected mice...
March 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28288843/non-invasive-diagnosis-of-cutaneous-leishmaniasis-by-the-direct-boil-loop-mediated-isothermal-amplification-method-and-minion%C3%A2-nanopore-sequencing
#12
Kazuo Imai, Norihito Tarumoto, Kiyoko Amo, Makoto Takahashi, Naoya Sakamoto, Atsushi Kosaka, Yasuyuki Kato, Kei Mikita, Jun Sakai, Takashi Murakami, Yutaka Suzuki, Shigefumi Maesaki, Takuya Maeda
Cutaneous leishmaniasis (CL) is gaining attention as a public health problem. We present two cases of CL imported from Syria and Venezuela in Japan. We diagnosed them as CL non-invasively by the direct boil loop-mediated isothermal amplification method and an innovative sequencing method using the MinION™ sequencer. This report demonstrates that our procedure could be useful for the diagnosis of CL in both clinical and epidemiological settings.
March 11, 2017: Parasitology International
https://www.readbyqxmd.com/read/28285499/clinico-epidemiological-patterns-of-cutaneous-leishmaniasis-patients-attending-the-anuradhapura-teaching-hospital-sri-lanka
#13
Lahiru Sandaruwan Galgamuwa, Buthsiri Sumanasena, Lalani Yatawara, Susiji Wickramasinghe, Devika Iddawela
Cutaneous leishmaniasis (CL) caused by Leishmania donovani is an endemic vector-borne disease in Sri Lanka. Over 2,500 cases have been reported since 2000 and the number of CL cases has dramatically increased annually. Total 57 clinically suspected CL patients attending the dermatology clinic in Anuradhapura Teaching Hospital were recruited from January to June 2015. Slit skin smears and skin biopsies were taken from each of the subjects. Clinical and epidemiological data were obtained using interviewer administered questionnaire...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28283136/temporal-dynamics-of-phlebotomine-sand-flies-population-in-response-to-ambient-temperature-variation-bam-kerman-province-of-iran
#14
Mansour Halimi, Zahra Zarei Cheghabaleki, Mohammad Jafari Modrek, Mahdi Delavari
BACKGROUND: Variations in climate condition may have changed the dynamic of zoonotic cutaneous leishmaniasis (ZCL) and its agents such as sand flies and reservoir in the Bam Kerman the dry region of Iran. OBJECTIVES: In this study we intend to examine the seasonal and interannual dynamics of the phlebotomine mosquito as a function of ambient temperature in Bam, Kerman one of the main leshmaniasis prevalence area in Iran. METHODS: The MODIS land surface temperature product (LST; MODIS/Terra LST/E Monthly L3 Global 0...
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28281913/rapidly-progressing-facial-leishmaniasis-effective-treatment-with-liposomal-amphotericin-b-and-a-review-of-the-management-of-old-world-cutaneous-leishmaniasis
#15
Shamim Islam
Cutaneous leishmaniasis (CL), a common condition in many parts of the world, is being increasingly encountered in non-endemic countries secondary to immigration. The clinical manifestations and course can vary substantially, with appropriate management ranging from observation for self-healing lesions to urgent treatment to prevent damaging anatomical and cosmetic sequelae. While there are now several effective medications, optimal therapy is not well defined, and decision-making can be challenged by the location of lesions and various drug issues, including availability, mode of delivery and adverse effects...
March 10, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28280494/a-chimera-containing-cd4-and-cd8-t-cell-epitopes-of-the-leishmania-donovani-nucleoside-hydrolase-nh36-optimizes-cross-protection-against-leishmania-amazonesis-infection
#16
Marcus Vinícius Alves-Silva, Dirlei Nico, Alexandre Morrot, Marcos Palatnik, Clarisa B Palatnik-de-Sousa
The Leishmania donovani nucleoside hydrolase (NH36) and NH A34480 of Leishmania amazonensis share 93% of sequence identity. In mice, the NH36 induced protection against visceral leishmaniasis is mediated by a CD4+ T cell response against its C-terminal domain (F3). Besides this CD4+ Th1 response, prevention and cure of L. amazonensis infection require also additional CD8+ and regulatory T-cell responses to the NH36 N-terminal (F1 domain). We investigated if mice vaccination with F1 and F3 domains cloned in tandem, in a recombinant chimera, with saponin, optimizes the vaccine efficacy against L...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28276641/cost-effectiveness-analysis-of-thermotherapy-versus-pentavalent-antimonials-for-the-treatment-of-cutaneous-leishmaniasis
#17
Jaiberth Antonio Cardona-Arias, Liliana López-Carvajal, Mery Patricia Tamayo Plata, Iván Darío-Vélez
OBJECTIVE: The treatment of cutaneous leishmaniasis is toxic, has contraindications and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. METHODS: Effectiveness was the proportion of healing, and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing were conducted...
February 5, 2017: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28276497/leishmania-leishmania-amazonensis-induces-macrophage-mir-294-and-mir-721-expression-and-modulates-infection-by-targeting-nos2-and-l-arginine-metabolism
#18
Sandra Marcia Muxel, Maria Fernanda Laranjeira-Silva, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter
Leishmania (Leishmania) amazonensis is an intracellular protozoan parasite responsible for the cutaneous leishmaniasis. The parasite replicates inside mammalian macrophage to establish infection. Host-pathogen interactions result in microRNA-mediated post-transcriptional regulation of host genes involved in inflammatory immune response. We analyzed macrophage miRNA profiles during L. (L.) amazonensis infection. The regulation of macrophage miRNA expression by the parasite correlates with/depends on parasite arginase activity during infection...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28274283/topical-tamoxifen-in-the-therapy-of-cutaneous-leishmaniasis
#19
Cristiana T Trinconi, Juliana Q Reimão, Vivian I Bonano, Caroline R Espada, Danilo C Miguel, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana
The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial combinations in an experimental model of cutaneous leishmaniasis. BALB/c mice infected with a luciferase expressing line of Leishmania amazonensis were treated with topical tamoxifen in two different formulations (ethanol or oil-free cream) as monotherapy or in co-administration with pentavalent antimonial. Treatment efficacy was evaluated by lesion size and parasite burden, quantified through luminescence, at the end of treatment and 4 weeks later...
March 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28267441/natural-infection-of-nesokia-indica-with-leishmania-major-and-leishmania-infantum-parasites-in-damghan-city-northern-iran
#20
Behrad Pourmohammadi, Sadegh Mohammadi-Azni, Mohsen Kalantari
Various species of rodents are proven reservoir hosts of zoonotic cutaneous leishmaniasis in different provinces of Iran and potential reservoir hosts of zoonotic visceral leishmaniasis. Therefore, this study was conducted to determine the leishmanial infection of rodents in Damghan city from April to September, 2015. Sum of 100 rodents of three species; Nesokia indica (95), Mus musculus (3), and Microtus socialis (2), were trapped alive and their tissue samples were examined using parasitological and molecular (nested-PCR) methods...
March 4, 2017: Acta Tropica
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