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cutanous leishmaniasis

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https://www.readbyqxmd.com/read/28228154/circulating-species-of-leishmania-at-microclimate-area-of-boulemane-province-morocco-impact-of-environmental-and-human-factors
#1
Asmae Hmamouch, Mahmoud Mohamed El Alem, Maryam Hakkour, Fatima Amarir, Hassan Daghbach, Khalid Habbari, Hajiba Fellah, Khadija Bekhti, Faiza Sebti
BACKGROUND: Cutaneous leishmaniasis (CL) is widely distributed in Morocco where its geographical range and incidence are related to environmental factors. This study aimed to examine the impact of several factors on the distribution of CL in Boulemane Province, which is characterized by several microclimates, and to identify the Leishmania species circulating in these areas. METHODS: Ordinary least squares regression (OLSR) analysis was performed to study the impact of poverty, vulnerability, population density, urbanization and bioclimatic factors on the distribution of CL in this province...
February 22, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28224222/immunopathological-characterization-of-human-cutaneous-leishmaniasis-lesions-caused-by-leishmania-viannia-spp-in-amazonian-brazil
#2
Cláudia Maria Castro Gomes, Maria Gloria Teixeira Sousa, Joyce Prieto Bezerra Menezes, Marliane Campos Batista, Ana Carolina Stocco Lima, Walter Belda, Daniel Bradshaw, Monica Elinor Alves Gama, Márcia Dalastra Laurenti, Fernando Tobias Silveira, Carlos Eduardo Pereira Corbett
American cutaneous leishmaniasis (ACL) is a chronic infectious disease caused by different protozoan species of Leishmania, and it is endemic in both tropical and subtropical countries. Using immunohistochemistry, we investigate the density of CD68(+), lysozyme(+), CD1a(+), factor XIIIa(+), CD4(+), CD8(+), CD56(+), interferon (IFN)-γ(+), and inducible NO synthase (iNOS(+)) cells. These cells were analyzed from 22 biopsy samples obtained from the lesions of ACL patients, whose infection was caused by Leishmania (Viannia) spp...
February 21, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28222637/genotyping-leishmania-promastigotes-isolated-from-patients-with-cutaneous-leishmaniasis-in-south-eastern-turkey
#3
Fahriye Ekşi, Orhan Özgöztaşı, Tekin Karslıgil, Mustafa Sağlam
Objective Cutaneous leishmaniasis (CL) is a significant disease in south-eastern Anatolia because it is prevalent among Syrian refugees. We identified the causative Leishmania species in CL patients using molecular methods. Methods Novy-MacNeal-Nicolle medium was inoculated with aspirated fluid from suspected CL lesions and tested for amastigotes with Giemsa staining. PCR amplified the internal transcribed spacer 1 (ITS1) of the Leishmania genome in cultures containing Leishmania promastigotes from 100 patients, which were genotyped with a restriction fragment length polymorphism (RFLP) analysis...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28219639/leishmania-l-amazonensis-induces-hyperalgesia-in-balb-c-mice-contribution-of-endogenous-spinal-cord-tnf%C3%AE-and-nf%C3%AE%C2%BAb-activation
#4
Sergio M Borghi, Victor Fattori, Kenji W Ruiz-Miyazawa, Milena M Miranda-Sapla, Rúbia Casagrande, Phileno Pinge-Filho, Wander R Pavanelli, Waldiceu A Verri
: Cutaneous leishmaniasis (CL) is the most common form of the leishmaniasis in humans. Ulcerative painless skin lesions are predominant clinical features of CL. Wider data indicate pain accompanies human leishmaniasis, out with areas of painless ulcerative lesions per se. In rodents, Leishmania (L.) major infection induces nociceptive behaviors that correlate with peripheral cytokine levels. However, the role of the spinal cord in pain processing after Leishmania infection has not been investigated...
February 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28216726/desert-dermatoses-thar-desert-india
#5
Col Manas Chatterjee
Desert dermatology describes the cutaneous changes and the diseases affecting those living in the desert. Diurnal variation in temperature is high and is characteristic of the deserts. The lack of water affects daily activities and impacts dermatological conditions. Adaptation to the desert is, therefore, important to survival. Infections are the most common conditions seen among this population, and among them, fungal infections are the most common. The high incidence of these infections would be accounted for by the poor hygienic conditions due to lack of bathing facilities due to scarcity of water and the consequent sweat retention and overgrowth of cutaneous infective organisms...
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28210511/unusual-presentation-of-cutaneous-leishmaniasis-ocular-leishmaniasis
#6
Masoud Doroodgar, Moein Doroodgar, Abbas Doroodgar
The leishmaniases are parasitic diseases that are transmitted to humans by infected female sandflies. Cutaneous leishmaniasis (CL) is one of 3 main forms of the disease. CL is the most common form of the disease and is endemic in many urban and rural parts of Iran and usually caused by two species of Leishmania: L. major and L. tropica. We report a case of unusual leishmaniasis with 25 lesions on exposed parts of the body and right eyelid involvement (ocular leishmaniasis). The patient was a 75-year-old male farmer referred to health care center in Aran va Bidgol city...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28209553/intraspecific-genetic-variability-in-a-population-of-moroccan-leishmania-infantum-revealed-by-pcr-rflp-of-kdna-minicircles
#7
Adil El Hamouchi, Rajaa Ejghal, Moustapha Hida, Meryem Lemrani
In Morocco, Leishmania infantum is the main etiologic agent of human and canine visceral leishmaniasis (VL). This species has been proven to be an opportunistic agent in HIV+ patients and is also responsible of sporadic cutaneous leishmaniasis (CL).This work aims to evaluate the genetic variability of Moroccan L. infantum strains based on PCR-RFLP analysis of the kinetoplastid DNA (kDNA) minicircles. A total of 75 DNA samples extracted from positive Giemsa-stained smears (n=32) and from L. infantum cultures (n=43) was studied...
February 14, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28207936/th17-cells-and-neutrophils-close-collaborators-in-chronic-leishmania-mexicana-infections-leading-to-disease-severity
#8
Claudia Patricia Pedraza-Zamora, José Delgado-Domínguez, Jaime Zamora-Chimal, Ingeborg Becker
Cutaneous leishmaniasis caused by Leishmania mexicana is associated with an important inflammatory response. We here analyzed the kinetics of Th17 cells and neutrophils in earlobe lesions caused by Leishmania mexicana throughout 90 days of disease progresion in susceptible BALB/c and semi-resistant C57BL/6 mice infected with 1x10(5) Leishmania mexicana promastigotes. Cells in the lesions were extracted and quantified by flow cytometry, whereas their distribution in the tissues in relation to the parasites was analyzed by immunohistochemistry...
February 16, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28202077/repellent-effects-of-the-essential-oils-of-cymbopogon-citratus-and-tagetes-minuta-on-the-sandfly-phlebotomus-duboscqi
#9
Albert Kimutai, Moses Ngeiywa, Margaret Mulaa, Peter G N Njagi, Johnstone Ingonga, Lydia B Nyamwamu, Cyprian Ombati, Philip Ngumbi
BACKGROUND: The sandfly, Phlebotomus duboscqi is a vector of zoonotic cutaneous leishmaniasis (ZCL) that is an important public health problem in Eastern Africa. Repellents have been used for protection of humans against vectors of ZCL and other vectors that transmit killer diseases including malaria, Rift Valley fever, dengue, and yellow fever. The repellent effects of different doses of the essential oils from the lemon grass, Cymbopogon citratus and Mexican marigold, Tagetes minuta were evaluated in a two-chamber bioassay against 3- to 7-day-old unfed females of P...
February 15, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28199331/correction-prevalence-of-cutaneous-leishmaniasis-in-districts-of-high-and-low-endemicity-in-mali
#10
Bourama Traoré, Fabiano Oliveira, Ousmane Faye, Adama Dicko, Cheick A Coulibaly, Ibrahim M Sissoko, Samake Sibiry, Nafomon Sogoba, Moussa Brema Sangare, Yaya I Coulibaly, Pierre Traore, Sekou F Traore, Jennifer M Anderson, Somita Keita, Jesus G Valenzuela, Shaden Kamhawi, Seydou Doumbia
[This corrects the article DOI: 10.1371/journal.pntd.0005141.].
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28193741/coinfection-of-leishmania-guyanensis-and-human-immunodeficiency-virus-acquired-immune-deficiency-syndrome-report-of-a-case-of-disseminated-cutaneous-leishmaniasis-in-ecuador
#11
Manuel Calvopina, Cristina Aguirre, William Cevallos, Alberto Castillo, Ibrahim Abbasi, Alon Warburg
Reported herein is the first case of Leishmania-human immunodeficiency virus (HIV) coinfection in Ecuador. In Ecuador, HIV infections overlap endemic areas of leishmaniasis. Immunosuppression is a well-established risk factor for developing severe disease. This is a severe case of a 32-year-old man presenting with disseminated pleomorphic ulcers, papules, and cutaneous plaque-like lesions over his whole body. Numerous amastigotes were observed in both skin scrapings and biopsies. The sequence of the cytochrome b gene confirmed the presence of Leishmania guyanensis The patient was treated but failed to respond to meglumine antimoniate and amphotericin B...
February 13, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28192528/cd8-t-cell-cytotoxicity-mediates-pathology-in-the-skin-by-inflammasome-activation-and-il-1%C3%AE-production
#12
Fernanda O Novais, Augusto M Carvalho, Megan L Clark, Lucas P Carvalho, Daniel P Beiting, Igor E Brodsky, Edgar M Carvalho, Phillip Scott
Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in several conditions. However, we have little understanding of the mechanisms by which immunopathology develops as a consequence of cytotoxicity. Using murine models of inflammation induced by the protozoan parasite leishmania, and data obtained from patients with cutaneous leishmaniasis, we uncovered a previously unrecognized role for NLRP3 inflammasome activation and IL-1β release as a detrimental consequence of CD8+ T cell-mediated cytotoxicity, ultimately resulting in chronic inflammation...
February 13, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28177049/n-acetyl-cysteine-inhibits-liver-oxidative-stress-markers-in-balb-c-mice-infected-with-leishmania-amazonensis
#13
Juciano Gasparotto, Alice Kunzler, Mario Roberto Senger, Celeste da Silva Freitas de Souza, Salvatore Giovanni de Simone, Rafael Calixto Bortolin, Nauana Somensi, Felipe Dal-Pizzol, José Claudio Fonseca Moreira, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese, Floriano Paes Silva, Daniel Pens Gelain
BACKGROUND: Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES: To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on these parameters. METHODS: Four months after infection, oxidative and inflammatory parameters of liver, kidneys, spleen, heart and lungs from BALB/c mice were assessed...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28177045/maxadilan-simile-expression-in-nyssomyia-neivai-a-sandfly-vector-in-an-endemic-region-of-brazil-and-its-immunogenicity-in-patients-with-american-tegumentary-leishmaniasis
#14
Juliana Aires, Claudio Casanova, Sebastian Vernal, Margarida Nascimento, Sandra Rodrigues, Ethan A Lerner, Ana Maria Roselino
BACKGROUND: Maxadilan (Max) is a salivary component in the sandfly Lutzomyia longipalpis (Lutz & Neiva 1912), a vector of visceral leishmaniasis. Max has a powerful vasodilatory effect and is a candidate vaccine that has been tested in experimental leishmaniasis. Nyssomyia neivai (Pinto 1926) is a vector of the pathogen responsible for American tegumentary leishmaniasis (ATL) in Brazil. OBJECTIVE: We searched for Max expression in Ny. neivai and for antibodies against Max in ATL patients...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28177044/comparison-of-lamp-and-pcr-for-molecular-mass-screening-of-sand-flies-for-leishmania-martiniquensis-infection
#15
Saruda Tiwananthagorn, Hirotomo Kato, Ranchana Yeewa, Amontip Muengpan, Raxsina Polseela, Saovanee Leelayoova
BACKGROUND: Leishmaniasis caused by Leishmania martiniquensis infection has been reported in human and domestic animals of Martinique Island, Germany, Switzerland, USA, Myanmar and Thailand. The peculiar clinical features of disseminated cutaneous and visceral forms co-existence render the urgent need of specific diagnostic tool to identify the natural sand fly vectors for effective prevention and control strategies. Loop-mediated isothermal amplification (LAMP) of 18S rRNA gene as well as polymerase chain reaction (PCR) of minicircle kinetoplast DNA gene (PCR-mkDNA) have never been applied to detect L...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28168727/comparison-of-pro-inflammatory-cytokines-of-non-healing-and-healing-cutaneous-leishmaniasis
#16
Mohammad Moafi, Hossein Rezvan, Roya Sherkat, Roya Taleban, Ali Asilian, Sayyed Hamid Zarkesh-Esfahani, Mohammad Ali Nilforoushzadeh, Fariba Jaffary, Marjan Mansourian, Fatemeh Sokhanvari, Nazli Ansari
Cutaneous Leishmaniasis (CL) heals spontaneously within several weeks or months, but, in rare cases, CL active lesions last for many years. In the current study, we assessed cell-mediated immunity in non-healing CL through the measurement of three pro-inflammatory cytokines: Interferon-γ (IFN-γ), IL-17a, and CXCL-11. For this, 32 patients afflicted with healing or non-healing CL were recruited in this study. Peripheral blood mononuclear cells (PBMCs) of every patient were treated with three antigens: purified protein derivative (PPD), soluble Leishmania antigen (SLA), and Phytohaemagglutinin (PHA)...
February 7, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28167598/in-vitro-sensitivity-of-cutaneous-leishmania-promastigote-isolates-circulating-in-french-guiana-to-a-set-of-drugs
#17
Marine Ginouvès, Stéphane Simon, Mathieu Nacher, Magalie Demar, Bernard Carme, Pierre Couppié, Ghislaine Prévot
Anti-leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of Leishmania isolates circulating in French Guiana and to highlight potential in vitro pentamidine-resistant isolates. This sensitivity study was conducted on 36 patient-promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit-8 viability test. The IC50 values obtained were heterogeneous...
February 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28150041/evaluation-of-a-hypothetical-protein-for-serodiagnosis-and-as-a-potential-marker-for-post-treatment-serological-evaluation-of-tegumentary-leishmaniasis-patients
#18
Mariana Pedrosa Lima, Lourena Emanuele Costa, Mariana Costa Duarte, Daniel Menezes-Souza, Beatriz Cristina Silveira Salles, Thaís Teodoro de Oliveira Santos, Fernanda Fonseca Ramos, Miguel Angel Chávez-Fumagalli, Amanda Christine Silva Kursancew, Roberta Passamani Ambrósio, Bruno Mendes Roatt, Ricardo Andrez Machado-de-Ávila, Denise Utsch Gonçalves, Eduardo Antonio Ferraz Coelho
The serodiagnosis for tegumentary leishmaniasis (TL) presents problems related to the sensitivity and/or specificity of the tests. In the present study, an enzyme-linked immunosorbent assay (ELISA) technique was used to evaluate the performance from a Leishmania braziliensis hypothetical protein, LbHyM, in an attempt to compare its serological reactivity with a soluble Leishmania antigenic preparation (SLA) for the serodiagnosis of cutaneous (CL) and mucosal (ML) leishmaniasis. LbHyM was predicted to be a kinesin-like protein by bioinformatics tools...
February 1, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28141598/leishmaniasis-recidivans-in-ethiopia-cutaneous-and-mucocutaneous-features
#19
Federica Dassoni, Frehiwot Daba, Bernard Naafs, Aldo Morrone
Cutaneous leishmaniasis (CL) is endemic in Ethiopia. An unusual clinical form of this disease is leishmaniasis recidivans (LR), a prolonged, relapsing form of cutaneous leishmaniasis resembling tuberculosis of the skin that may persist for many years with a chronic and relapsing course. This rare variant has been shown to be caused by Leishmania tropica species in the Old World and by Leishmania braziliensis, Leishmania amazonensis, Leishmania panamensis, and Leishmania guyanensis in the New World, as reported in various studies...
January 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28137819/use-of-optical-imaging-technology-in-the-validation-of-a-new-rapid-cost-effective-drug-screen-as-part-of-a-tiered-in-vivo-screening-paradigm-for-development-of-drugs-to-treat-cutaneous-leishmaniasis
#20
Diana Caridha, Sandi Parriot, Thomas H Hudson, Thierry Lang, Franklyn Ngundam, Susan Leed, Jenell Sena, Michael Harris, Michael O'Neil, Richard Sciotti, Lisa Read, Herve Lecoeur, Mark Hickman, Max Grogl
In any drug discovery and development effort, reduction in the lead optimization cycle is critical to decrease the time to license and reduce cost. In addition, ethical guidelines call for more ethical use of animals to minimize the number of animals used and decrease their suffering. Therefore, any cutaneous Leishmaniasis drug development effort requires multiple tiers of in vivo testing that start with higher-throughput efficacy assessments and progress to lower-throughput models with the most clinical relevance...
January 30, 2017: Antimicrobial Agents and Chemotherapy
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