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cutanous leishmaniasis

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https://www.readbyqxmd.com/read/29155831/prevalence-and-risk-factors-associated-with-leishmania-infection-in-trang-province-southern-thailand
#1
Jipada Manomat, Saovanee Leelayoova, Lertwut Bualert, Peerapan Tan-Ariya, Suradej Siripattanapipong, Mathirut Mungthin, Tawee Naaglor, Phunlerd Piyaraj
BACKGROUND: Autochthonous cutaneous and visceral leishmaniasis (VL) caused by Leishmania martiniquensis and Leishmania siamensis have been considered emerging infectious diseases in Thailand. The disease burden is significantly underestimated, especially the prevalence of Leishmania infection among HIV-positive patients. METHODS: A cross-sectional study was conducted to determine the prevalence and risk factors associated with Leishmania infection among patients with HIV/AIDS living in Trang province, southern Thailand, between 2015 and 2016...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29155816/liposomal-amphotericin-b-in-travelers-with-cutaneous-and-muco-cutaneous-leishmaniasis-not-a-panacea
#2
Romain Guery, Benoit Henry, Guillaume Martin-Blondel, Claire Rouzaud, Florence Cordoliani, Gundel Harms, Jean-Pierre Gangneux, Françoise Foulet, Emmanuelle Bourrat, Michel Baccard, Gloria Morizot, Paul-Henri Consigny, Antoine Berry, Johannes Blum, Olivier Lortholary, Pierre Buffet
BACKGROUND: Complex cutaneous and muco-cutaneous leishmaniasis (CL and MCL) often requires systemic therapy. Liposomal amphotericin B (L-AmB) has a strong potential for a solid clinical benefit in this indication. METHODS: We conducted a retrospective analysis of data from a French centralized referral treatment program and from the "LeishMan" European consortium database. All patients with parasitologically proven CL or MCL who received at least one dose of L-AmB were included...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29153064/-comparison-of-polymerase-chain-reaction-using-kinetoplast-dna-specific-primers-and-other-parasitological-methods-in-the-diagnosis-of-clinical-samples-of-suspected-patients-with-cutaneous-leishmaniasis-in-%C3%A5-anl%C3%A4-urfa
#3
Fadile Yıldız Zeyrek, Seray Töz, Fehmi Yüksel, Nevin Turgay, Yusuf Özbel
Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are seen endemically in Turkey and CL caused by Leishmania tropica is an important public health problem in southeastern as well as other regions of Turkey. The diagnosis has been usually made by clinical view of lesion and/or parasitologically using lesion aspiration smears. Histological examination does not, always reveal the parasite in the skin biopsy, particularly in chronic lesions. Besides this, due to CL infections caused by different species in endemic areas, diagnostic methods enabling species identification are in great need...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29149474/interventions-for-old-world-cutaneous-leishmaniasis
#4
REVIEW
Julio Heras-Mosteiro, Begoña Monge-Maillo, Mariona Pinart, Patricia Lopez Pereira, Emely Garcia-Carrasco, Pedro Campuzano Cuadrado, Ana Royuela, Irene Mendez Roman, Rogelio López-Vélez
BACKGROUND: Cutaneous leishmaniasis, caused by a parasitic infection, is considered one of the most serious skin diseases in many low- and middle-income countries. Old World cutaneous leishmaniasis (OWCL) is caused by species found in Africa, Asia, the Middle East, the Mediterranean, and India. The most commonly prescribed treatments are antimonials, but other drugs have been used with varying success. As OWCL tends to heal spontaneously, it is necessary to justify the use of systemic and topical treatments...
November 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29141753/serological-evaluation-of-cutaneous-leishmania-tropica-infection-in-northern-israel
#5
Iva Rohoušová, Dalit Talmi-Frank, Michaela Vlková, Tatiana Spitzová, Koranit Rishpon, Charles L Jaffe, Petr Volf, Gad Baneth, Moshe Efrat
Leishmania spp. are medically important unicellular parasites transmitted by phlebotomine sand flies. The World Health Organization recently highlighted the importance of reliable diagnostic tools for leishmaniasis. Our study of human infection was conducted in two endemic foci of Leishmania tropica in the Galilee region, northern Israel. Elevated anti-Leishmania antibodies were present in the majority (78.6%) of L. tropica-PCR positive individuals. Moreover, the enzyme-linked immunosorbent assay showed high sensitivity, specificity, and negative and positive predictive values (ranging between 73% and 79%), thus fulfilling the basic requirement for future development of a serodiagnostic and screening tool...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141751/assessment-of-a-leishmaniasis-reporting-system-in-tropical-bolivia-using-the-capture-recapture-method
#6
Daniel Eid, Miguel Guzman-Rivero, Ernesto Rojas, Isabel Goicolea, Anna-Karin Hurtig, Daniel Illanes, Miguel San Sebastian
This study evaluates the level of underreporting of the National Program of Leishmaniasis Control (NPLC) in two communities of Cochabamba, Bolivia during the period 2013-2014. Montenegro skin test-confirmed cases of cutaneous leishmaniasis (CL) were identified through active surveillance during medical campaigns. These cases were compared with those registered in the NPLC by passive surveillance. After matching and cleaning data from the two sources, the total number of cases and the level of underreporting of the National Program were calculated using the capture-recapture analysis...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29135995/efficacy-of-a-new-rapid-diagnostic-test-kit-to-diagnose-sri-lankan-cutaneous-leishmaniasis-caused-by-leishmania-donovani
#7
Gayani De Silva, Vijani Somaratne, Sujai Senaratne, Manuja Vipuladasa, Rajitha Wickremasinghe, Renu Wickremasinghe, Shalindra Ranasinghe
BACKGROUND: Cutaneous leishmaniasis (CL) in Sri Lanka is caused by Leishmania donovani. This study assessed the diagnostic value of a new rapid diagnostic immunochromatographic strip (CL-Detect™ IC-RDT), that captures the peroxidoxin antigen of Leishmania amastigotes. METHODOLOGY/PRINCIPAL FINDINGS: We sampled 74 clinically suspected CL lesions, of which 59 (79.7%) were positive by PCR, 43 (58.1%) by Giemsa stained slit skin smear (SSS) and 21 (28.4%) by the new IC-RDT...
2017: PloS One
https://www.readbyqxmd.com/read/29129568/cutaneous-leishmaniasis-distinct-functions-of-dendritic-cells-and-macrophages-in-the-interaction-of-the-host-immune-system-with-leishmania-major
#8
REVIEW
Esther von Stebut, Stefan Tenzer
Leishmaniasis is transmitted by sand flies leading to parasite inoculation into skin. In the mammalian host, the parasite primarily resides in skin macrophages (MΦ) and dendritic cells (DC). MΦ are silently invaded by the parasite eliciting a stress response, whereas DC become activated, release IL-12, and prime antigen-specific T cells. Here we review the basics of the immune response against this human pathogen and elucidate the role and function DC and MΦ for establishment of protective immunity against leishmaniasis...
November 6, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29126812/infectious-disease-risks-among-refugees-from-north-korea
#9
Hiroshi Nishiura, Hyojung Lee, Baoyin Yuan, Akira Endo, Andrei R Akhmetzhanov, Gerardo Chowell
OBJECTIVES: Disease characteristics of North Korea including severe malnutrition and infectious disease risks have not been openly and widely analyzed. The present study aimed to estimate infectious disease risks among refugees from North Korea. METHODS: To statistically estimate risks of infectious diseases among North Korean, literature review of clinical studies among North Korean defectors was conducted. RESULTS: A total of six groups of data from five publications were identified from 2004 to 2014...
November 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29125243/wing-morphology-variations-in-a-natural-population-of-phlebotomus-tobbi-adler-and-theodor-1930
#10
Gizem Oguz, Ozge Erisoz Kasap, Bulent Alten
Cutaneous leishmaniasis (CL) is highly endemic in the Cukurova region, located on the crossroads of main refugee routes from the Middle East to Europe on the eastern Mediterranean part of Turkey. Our purpose was to investigate the phenotypic variation of Phlebotomus tobbi, the known vector of CL in the region, during one active season. Sand flies and microclimatic data were collected monthly from May to October, 2011, from five locations in six villages in the study area. A geometric morphometric approach was used to investigate wing morphology...
December 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/29119087/a-new-primary-health-care-system-in-the-syrian-opposition-territories-good-effort-but-far-from-being-perfect
#11
Tarek Alsaied, Abdullah Mawas, Fatima Al Sayah, Abdulrazzak Kental, Maher Saqqur
Objectives: The primary health-care system in Syria has suffered a great deal of damage over the past 6 years. A large number of physicians and health-care providers have left the country. The objectives of this study are to describe our experience in establishing a primary health-care system in the opposition territories (OTs) in Syria and report the most common treated diseases. Methods: The administrative databases of ten primary care centers in the OT from January 2014 to December 2015 were reviewed...
October 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29114151/spatio-temporal-analysis-of-cutaneous-leishmaniasis-using-geographic-information-system-among-iranian-army-units-and-its-comparison-with-the-general-population-of-iran-during-2005-2014
#12
Reza Pakzad, Arasb Dabbagh-Moghaddam, Mehdi Mohebali, Saeid Safiri, Mohammad Barati
To investigate the time trend and distribution of cutaneous leishmaniasis in Iranian Army Units (IAUs) and general population (GP). with using census, Data on CL incidence in IAUs (from AJA University of Medical Sciences) and GP (from Ministry of Health) during 2005-2014 were extracted and entered into the GIS software. Cochran-Armitage test, choropleth map, hot-spot analysis and high/low clustering analysis were used to determine time trend, distribution of disease, hot-spots, and possible abnormal clustering, respectively...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29113609/dermotropic-leishmania-donovani-in-sri-lanka-visceralizing-potential-in-clinical-and-preclinical-studies
#13
K K G D U L Kariyawasam, A Selvapandiyan, H V Y D Siriwardana, A Dube, P Karunanayake, S A S C Senanayake, R Dey, S Gannavaram, H L Nakhasi, N D Karunaweera
The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka (L. donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) patients and in vivo and in vitro experimental infection models. CL patients (n = 250) treated effectively with intra-lesional antimony therapy were followed-up six monthly for 4 years. There was no clinical evidence of visceralization of infection (VL) during this period. Infection of BALB/c mice with L. donovani-SL (test) through intra-dermal route led to the development of cutaneous lesions at the site of inoculation with no signs of systemic dissemination, in contrast to the observations made in animals similarly infected with a visceralizing strain of L...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29111137/biogenic-silver-nanoparticles-inducing-leishmania-amazonensis-promastigote-and-amastigote-death-in-vitro
#14
Jacqueline Rodrigues Fanti, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, Allan Henrique Depieri Cataneo, Célia Guadalupe Tardeli de Jesus Andrade, Carolina Panis, Jean Henrique da Silva Rodrigues, Pryscilla Fanini Wowk, Diogo Kuczera, Idessania Nazareth Costa, Celso Vataru Nakamura, Gerson Nakazato, Nelson Durán, Wander Rogério Pavanelli, Ivete Conchon-Costa
American Cutaneous Leishmaniasis (ACL) is a zoonosis caused by Leishmania protozoa. The ACL chemotherapy available is unsatisfactory motivating researches to seek alternative treatments. In this study, we investigated the action of biogenic silver nanoparticle (AgNp-bio) obtained from Fusarium oxysporium, against Leishmania amazonensis promastigote and amastigote forms. The AgNp-bio promastigote treatment results in promastigote death leading to apoptosis-like events due an increased production of reactive oxygen species (ROS), loss of mitochondrial integrity, phosphatidylserine exposure and damage on promastigotes membrane...
October 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29107954/distribution-and-identification-of-sand-flies-naturally-infected-with-leishmania-from-the-southeastern-peruvian-amazon
#15
Victor Zorrilla, Maxy B De Los Santos, Liz Espada, Rocío Del Pilar Santos, Roberto Fernandez, Albino Urquia, Craig A Stoops, Sarah-Blythe Ballard, Andres G Lescano, Gissella M Vásquez, Hugo O Valdivia
BACKGROUND: Cutaneous leishmaniasis (CL) is an important health problem in the New World affecting civilian and military populations that are frequently exposed in endemic settings. The Peruvian region of Madre de Dios located near the border with Brazil is one of the most endemic CL regions in South America with more than 4,451 reported cases between 2010 and 2015 according to the Peruvian epidemiology directorate. However, little is known regarding the diversity and distribution of sand fly vectors in this region...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29097645/susceptibility-status-of-wild-population-of-phlebotomus-sergenti-diptera-psychodidae-to-different-imagicides-in-a-endemic-focus-of-cutaneous-leishmaniasis-in-northeast-of-iran
#16
Kourosh Arzamani, Hassan Vatandoost, Yavar Rassi, Mohammad Reza Abai, Amir Ahmad Akhavan, Mohammad Alavinia, Kamran Akbarzadeh, Mehdi Mohebali, Sayena Rafizadeh
BACKGROUND & OBJECTIVES: Phlebotomine sandflies (Diptera: Psychodidae) transmit several important zoonotic diseases to humans and leishmaniasis is one of them. Two types of leishmaniasis, viz. visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are endemic in Iran. The main vector of anthroponotic cutaneous leishmaniasis (ACL) is Phlebotomus sergenti. The aim of the present study was to determine the susceptibility status of wild strain of P. sergenti to different imagicides of DDT, bendiocarb and permethrin at the median lethal time, LT50 level...
July 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29097638/investigation-of-the-spatial-distribution-of-sandfly-species-and-cutaneous-leishmaniasis-risk-factors-by-using-geographical-information-system-technologies-in-karaisali-district-of-adana-province-turkey
#17
Ozan Artun, Hakan Kavur
BACKGROUND & OBJECTIVES: Cutaneous leishmaniasis displays two epidemiological routes of transmission, zoonotic cutaneous leishmaniasis (ZCL) which includes animal reservoir hosts in the transmission cycle and anthroponotic cutaneous leishmaniasis (ACL), where human is the sole source of infection for the vector sandflies. About 10-13% of CL cases are reported each year from Adana province in Turkey. The aim of this study was to develop a predictive model for determining the spatial risk level of cutaneous leishmaniasis in the Adana province, southern part of Turkey, in relation to environmental factors...
July 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29097502/inhibitor-of-serine-peptidase-2-enhances-leishmania-major-survival-in-the-skin-through-control-of-monocytes-and-monocyte-derived-cells
#18
Amy Goundry, Audrey Romano, Ana Paula C A Lima, Jeremy C Mottram, Elmarie Myburgh
Leishmania major is the causative agent of the neglected tropical disease, cutaneous leishmaniasis. In the mouse, protective immunity to Leishmania is associated with inflammatory responses. Here, we assess the dynamics of the inflammatory responses at the lesion site during experimental long-term, low-dose intradermal infection of the ear, employing noninvasive imaging and genetically modified L. major Significant infiltrates of neutrophils and monocytes occurred at 1-4 d and 2-4 wk, whereas dermal macrophage and dendritic cell (DC) numbers were only slightly elevated in the first days...
November 2, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29096720/neglected-tropical-diseases-in-brazilian-children-and-adolescents-data-analysis-from-2009-to-2013
#19
Eduardo Brandão, Sebastián Romero, Maria Almerice Lopes da Silva, Fred Luciano Neves Santos
BACKGROUND: Neglected tropical diseases (NTDs) prevail in conditions of poverty and contribute to the maintenance of social inequality. Out of the NTDs prioritized by the Brazilian Ministry of Health, four parasitic infections require mandatory notification: acute Chagas disease, leishmaniasis, malaria, and schistosomiasis. Data on the behaviour of these NTDs in the young population are currently limited. This study seeks to analyse the epidemiological aspects of these parasitic infections in children and adolescents in Brazil...
November 3, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29096693/cutaneous-leishmaniasis-in-northwestern-saudi-arabia-identification-of-sand-fly-fauna-and-parasites
#20
Najoua Haouas, Omar Amer, Fawwaz Freih Alshammri, Shorooq Al-Shammari, Latifa Remadi, Ibrahim Ashankyty
BACKGROUND: Cutaneous leishmaniasis (CL) is a vector-borne disease transmitted by the bite of an infected sand fly. This disease is highly prevalent in Saudi Arabia where Leishmania major and L. tropica are the etiological agents. In the region of Hail, northwestern of Saudi Arabia, the incidence is about 183 cases/year. However, the epidemiology of the disease in this area is not well understood. Thus, an epidemiological survey was conducted in 2015-2016 to identify the circulating parasite and the sand fly fauna in the region of Hail...
November 2, 2017: Parasites & Vectors
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