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cutanous leishmaniasis

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https://www.readbyqxmd.com/read/29353004/leishmania-tropica-isolates-from-non-healed-and-healed-patients-in-iran-a-molecular-typing-and-phylogenetic-analysis
#1
Mehdi Bamorovat, Iraj Sharifi, Mohammad Ali Mohammadi, Sana Eybpoosh, Saeid Nasibi, Mohammad Reza Aflatoonian, Ahmad Khosravi
The precise identification of the parasite species causing leishmaniasis is essential for selecting proper treatment modality. The present study aims to compare the nucleotide variations of the ITS1, 7SL RNA, and Hsp70 sequences between non-healed and healed anthroponotic cutaneous leishmaniasis (ACL) patients in major foci in Iran. A case-control study was carried out from September 2015 to October 2016 in the cities of Kerman and Bam, in the southeast of Iran. Randomly selected skin-scraping lesions of 40 patients (20 non-healed and 20 healed) were examined and the organisms were grown in a culture medium...
January 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29345298/leishmania-amazonensis-isolated-from-human-visceral-leishmaniasis-histopathological-analysis-and-parasitological-burden-in-different-inbred-mice
#2
Celeste da Silva Freitas de Souza, Kátia da Silva Calabrese, Ana Lúcia Abreu-Silva, Luiz Otávio Pereira Carvalho, Flávia de Oliveira Cardoso, Maria Elizabeth Moraes Cavalheiros Dorval, Elisa Teruya Oshiro, Patrícia Flávia Quaresma, Célia Maria Ferreira Gontijo, Raquel da Silva Pacheco, Maria Isabel Doria Rossi, Sylvio Celso Gonçalves da Costa, Tânia Zaverucha do Valle
Leishmania amazonensis is a major etiological agent of human cutaneous leishmaniasis in the Americas; nevertheless there are some reports of this species causing visceral disease in dogs and men. In the present work we have studied a Leishmania strain isolated from a human case of visceral leishmaniasis. We have infected different mouse strains and analyzed the development of the disease, studying the parasite's ability to visceralize and whether this ability is influenced by host genetics. Female BALB/c, C57BL/6, C57BL/10, CBA, DBA/2, and C3H/He mice were subcutaneously infected with 104 L...
January 18, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29345220/tissue-impression-smears-as-a-supplementary-diagnostic-method-for-histopathology-in-cutaneous-leishmaniasis-in-sri-lanka
#3
Nuwani H Manamperi, M Vipula C de Silva, Nishantha Pathirana, Wimal Abeyewickreme, Nadira D Karunaweera
Cutaneous leishmaniasis (CL) is diagnosed mainly by light microscopy of smears made using lesion material. Histopathology is usually done in atypical presentations or when lesion smears are negative. Tissue impression smears (TIS) made from skin biopsy specimens were compared with histopathology for the diagnosis of CL. Out of the 111 patients included, 83 (74.8%) were positive by either methods. The TIS was positive in 70.3% whereas histopathology was positive in 56.8% of patients. Tissue impression smears can be used as a supplementary diagnostic test that gives sensitive and rapid results when tissue biopsies are used as the source of lesion material for diagnosis of CL...
January 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29342402/cutaneous-cryptococcosis-mimicking-leishmaniasis
#4
Alexandre Moretti de Lima, Milena Marchini Rodrigues, Carmelia Matos Santiago Reis
No abstract text is available yet for this article.
January 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29338557/biosynthesis-characterization-and-leishmanicidal-activity-of-a-biocomposite-containing-agnps-pvp-glucantime
#5
Ana Patricia Cacua Gélvez, Luis Henrique Seabra Farias, Victor Soares Pereira, Inaldo Claudio Martins da Silva, Ana Carolina Costa, Carmen Gilda Barroso Tavares Dias, Roseane Maria Ribeiro Costa, Silvia Helena Marques Da Silva, Ana Paula Drummond Rodrigues
AIM: Development of functionalized nanocomposites containing AgNPs-PVP-Glucantime® to evaluate their leishmanicidal activity as a novel method for improving the pharmacological properties of the drug Glucantime® against extracellular promastigotes and intracellular amastigotes of Leishmania amazonensis in vitro to treat cutaneous leishmaniasis. MATERIALS & METHODS: The silver nanoparticles and nanocomposites prepared containing silver nanoparticles, polyvinylpyrrolidone and different amounts of Glucantime were characterized using transmission electron microscopy, x-ray diffraction, energy-dispersive x-ray spectroscopy and ζ potential analysis; in addition, the in vitro cytotoxicity was evaluated...
January 17, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29329311/harmonized-clinical-trial-methodologies-for-localized-cutaneous-leishmaniasis-and-potential-for-extensive-network-with-capacities-for-clinical-evaluation
#6
Piero Olliaro, Max Grogl, Marina Boni, Edgar M Carvalho, Houda Chebli, Mamoudou Cisse, Ermias Diro, Gláucia Fernandes Cota, Astrid C Erber, Endalamaw Gadisa, Farhad Handjani, Ali Khanesipour, Alejandro Llanos-Cuentas, Liliana López Carvajal, Lise Grout, Badre Eddine Lmimouni, Mourad Mokni, Mohammad Sami Nahzat, Afif Ben Salah, Yusuf Ozbel, Juan Miguel Pascale, Nidia Rizzo Molina, Joelle Rode, Gustavo Romero, José Antonio Ruiz-Postigo, Nancy Gore Saravia, Jaime Soto, Soner Uzun, Vahid Mashayekhi, Ivan Dario Vélez, Florian Vogt, Olga Zerpa, Byron Arana
INTRODUCTION: Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backing current treatment recommendations, as shown by systematic reviews on old-world and new-world CL (OWCL and NWCL). MATERIALS AND METHODS: Using a previously published guidance paper on CL treatment trial methodology as the reference, consensus was sought on key parameters including core eligibility and outcome measures, among OWCL (7 countries, 10 trial sites) and NWCL (7 countries, 11 trial sites) during two separate meetings...
January 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29329207/arnica-tincture-cures-cutaneous-leishmaniasis-in-golden-hamsters
#7
Sara M Robledo, Ivan D Vélez, Thomas J Schmidt
In search for potential therapeutic alternatives to existing treatments for cutaneous Leishmaniasis, we have investigated the effect of Arnica tincture Ph. Eur. (a 70% hydroethanolic tincture prepared from flowerheads of Arnica montana L.) on the lesions caused by infection with Leishmania braziliensis in a model with golden hamsters. The animals were treated topically with a daily single dose of the preparation for 28 days. Subsequently, the healing process was monitored by recording the lesion size in intervals of 15 days up to day 90...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29322057/epidemiological-study-on-cutaneous-leishmaniasis-in-an-endemic-area-of-qom-province-central-iran
#8
Abedin Saghafipour, Hassan Vatandoost, Ali Reza Zahraei-Ramazani, Mohammad Reza Yaghoobi-Ershadi, Moharram Karami Jooshin, Yavar Rassi, Mohammad Reza Shirzadi, Amir Ahmad Akhavan, Ahmad Ali Hanafi-Bojd
Background: Cutaneous leishmaniasis (CL) is one of the most important health problems in many areas of Iran. There are two forms of the disease in Iran, anthroponotic and zoonotic CL. This study conducted to assess the epidemiological situation of CL in an endemic area of Qom Province, central Iran from Apr to Nov 2015. Methods: The sticky paper traps and aspirating tubes were used for collecting adult sand flies. Sherman traps and small insect nets were used to capture rodents and small mammals...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29322056/field-evaluation-of-outdoor-ultra-low-volume-ulv-applications-against-phlebotomine-sand-flies-diptera-psychodidae-in-al-rabta-north-west-of-libya
#9
Mostafa Ramahdan Dokhan, Mohamed Amin Kenawy, Taher Shaibi, Badereddin Bashir Annajar
Background: Al Rabta is a rural area in the North-West of Libya that represents an important focus of zoonotic cutaneous leishmaniasis. This study aimed to evaluate the effect of Ultra Low Volume (ULV) applications in controlling sand flies and its impact on leishmaniasis transmission in this area. Methods: Two neighboring villages were selected: Al Rabta West (RW) as cypermethrin treated village and Al Rabta East (RE) as check one. The ULV was evaluated through 3 spraying cycles during Apr, Jun and Sep 2013...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29322055/the-pcr-rflp-based-detection-and-identification-of-the-leishmania-species-causing-human-cutaneous-leishmaniasis-in-the-khorasan-razavi-province-northeast-of-iran
#10
Anita Mohammadiha, Abdolhossein Dalimi, Mohammad Reza Mahmoodi, Mehdi Parian, Majid Pirestani, Mehdi Mohebali
Background: Leishmania tropica, the causative agent of anthroponotic cutaneous leishmaniasis (ACL), and Leishmania major, which causes zoonotic cutaneous leishmaniasis (ZCL), are endemic in Iran. Methods: Cross-sectional study was designed to identify Leishmania species in cutaneous leishmaniasis patients who referred to Mashhad Health Centers from 2013 to 2014 using ITS-PCR-RFLP technique. First, physical examinations were performed in all suspected patients and CL cases were confirmed with microscopical examinations...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29318992/cutaneous-leishmaniasis-in-pediatric-patients-in-a-single-tertiary-hospital-in-ankara
#11
Ayşe Kaman, Gönül Tanır, Zeynep Gökçe Gayretli Aydın, Özge Metin, Türkan Aydın Teke, Fatma Nur Öz, Mesut Mungan
OBJECTIVE: Leishmaniasis is an infectious disease that is caused by a protozoan parasite of the Leishmania genus and that occurs worldwide. Leishmaniasis is endemic in southeastern Turkey and the neighboring Middle Eastern countries. The purpose of this study was to describe the clinical characteristics of patients admitted to our hospital with a diagnosis of cutaneous leishmaniasis (CL). METHODS: A total of 16 CL patients [11 (69%) boys and five (31%) girls] were admitted between January 2014 and December 2015...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29317889/clinical-and-laboratory-analysis-of-patients-with-leishmaniasis-a-retrospective-study-from-a-tertiary-care-center-in-new-delhi
#12
Nitin Gupta, Kamla Kant, Bijay Ranjan Mirdha
Background: Leishmaniasis manifests as visceral (VL), cutaneous (CL) or a dermal sequel of VL, known as Post kala-azar dermal leishmaniasis (PKDL). The aim of the study was to analyze the clinical and laboratory features of cases diagnosed with leishmaniasis. Methods: This hospital-based retrospective study included all cases of VL, PKDL, and CL diagnosed between Jan 2011 to Jan 2016 at All India Institute of Medical Sciences, New Delhi. Clinical and laboratory profile of the diagnosed cases were analyzed in detail...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317879/clinical-features-of-anthroponotic-cutaneous-leishmaniasis-in-a-major-focus-southeastern-iran-1994-2014
#13
Ahmad Khosravi, Iraj Sharifi, Alireza Fekri, Alireza Kermanizadeh, Mehdi Bamorovat, Mahshid Mostafavi, Mohammad Reza Aflatoonian, Alireza Keyhani
Background: Cutaneous leishmaniasis (CL) is associated with a broad and complex clinical spectrum of diseases. The objectives of this study were to assess the clinical features and identification of the causative agents of CL in a well-known focus of anthroponotic CL (ACL) caused by Leishmania tropica, southeast Iran. Methods: This study was performed randomly as a descriptive cross-sectional survey to evaluate 2000 CL patients by active and passive case-detection approaches in Kerman Province from 1994 to 2014...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317878/cytochrome-b-and-molecular-typing-of-leishmania-spp-in-a-passive-sampling-of-suspected-patients-with-cutaneous-leishmaniasis-in-sistan-and-baluchestan-province-eastern-iran
#14
Gholamreza Motalleb, Hadi Mirahmadi, Ahmad Zare-Zadeh, Ahmad Mehravaran
Background: Despite the high prevalence and drug resistance of disease in Sistan and Baluchestan Province of Iran, the species of cutaneous leishmaniasis (CL) has not been identified. In the present study, cytochrome b (Cyt b) was used in Sistan and Baluchestan to find species of Leishmania in suspected patients of CL using PCR-RFLP and DNA sequencing. Methods: This study was conducted from Oct 2015 to Oct 2016. The samples were collected from the individuals clinically suspected to CL and referred to Iran Shahr, Chabahar, Khash, Zabol, Zahedan, Mirjaveh, and Nikshahr health centers...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29304878/bionomic-aspects-of-lutzomyia-evansi-and-lutzomyia-longipalpis-proven-vectors-of-leishmania-infantum-in-an-endemic-area-of-non-ulcerative-cutaneous-leishmaniasis-in-honduras
#15
Ángel Mejía, Gabriela Matamoros, Gustavo Fontecha, Wilfredo Sosa-Ochoa
BACKGROUND: Some Lutzomyia species are the vectors of human leishmaniasis in the Americas. Visceral and cutaneous leishmaniasis are both endemic in the Pacific region of Honduras, but the non-ulcerative form is the more frequent clinical manifestation in this region, where Lutzomyia longipalpis is the most abundant and the only incriminated vector. Taxonomic identification and distribution studies of sand flies are important to understand the epidemiology and to control these neglected tropical diseases...
January 5, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29302149/epidemiological-trends-of-cutaneous-leishmaniasis-in-al-madinah-al-munawarah-province-western-region-of-saudi-arabia
#16
Miskelyemen Abdelatti Elmekki, Mogahid M Elhassan, Hani A Ozbak, Ilham T Qattan, Satti M Saleh, Ali H Alharbi
Objective: To investigate the epidemiological trends of cutaneous leishmaniasis (CL) in Al-Madinah Al-Munawarah, western region of KSA. Materials and Methods: Four hundred and sixty-seven parasitologically confirmed CL cases attending Al-Meeqat Hospital, Al-Madinah, during 2012-2015, were included in this study. Results: Both Saudi and non-Saudi nationals were infected, with the highest infection rate being among Saudis (68.7%). Males were more affected than females as 86...
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29297684/isolation-derivative-synthesis-and-structure-activity-relationships-of-antiparasitic-bromopyrrole-alkaloids-from-the-marine-sponge-tedania-brasiliensis
#17
Lizbeth L L Parra, Ariane F Bertonha, Ivan R M Severo, Anna C C Aguiar, Guilherme E de Souza, Glaucius Oliva, Rafael V C Guido, Nathalia Grazzia, Tábata R Costa, Danilo C Miguel, Fernanda R Gadelha, Antonio G Ferreira, Eduardo Hajdu, Daniel Romo, Roberto G S Berlinck
The isolation and identification of a series of new pseudoceratidine (1) derivatives from the sponge Tedania brasiliensis enabled the evaluation of their antiparasitic activity against Plasmodium falciparum, Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) infantum, and Trypanosoma cruzi, the causative agents of malaria, cutaneous leishmaniasis, visceral leishmaniasis, and Chagas disease, respectively. The new 3-debromopseudoceratidine (4), 20-debromopseudoceratidine (5), 4-bromopseudoceratidine (6), 19-bromopseudoceratidine (7), and 4,19-dibromopseudoceratidine (8) are reported...
January 3, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29297145/correction-to-molecular-identification-of-leishmania-spp-isolates-causes-cutaneous-leishmaniasis-cl-in-sanliurfa-province-turkey-where-cl-is-highly-endemic
#18
Gulcan Gurses, Mehmet Ozaslan, Fadile Yıldız Zeyrek, Ibrahim H Kılıç, Nebiye Yentür Doni, I Didem Karagoz, Nermin Uluca
In published article (Molecular Identification of Leishmania spp. Isolates Causes Cutaneous Leishmaniasis (CL) in Sanliurfa Province, Turkey, Where CL is Highly Endemic) Table 1 titled "The pH values of yogurts collected from villages in Turkey" doesn't belong to this article.
January 3, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29287805/role-of-environmental-climatic-risk-factors-and-livestock-animals-on-the-occurrence-of-cutaneous-leishmaniasis-in-newly-emerging-focus-in-iran
#19
Mohammad Amin Ghatee, Ali Akbar Haghdoost, Fatemeh Kooreshnia, Zahra Kanannejad, Zafar Parisaie, Mehdi Karamian, Abdolali Moshfe
INTRODUCTION: Occurrence of leishmaniasis is affected by various biological and environmental factors. Kohgiluye and Boyerahmad (K-B) province is an emerging focus of cutaneous leishmaniasis (CL) in Southwest Iran. SUBJECTS AND METHODS: To elucidate some angles of occurrence of CL in this province, climatic and environmental factors and close proximity to livestock were studied by univariate and two multivariate logistic regression models. The dwelling addresses of 275 CL patients were obtained from Health Centers records for a 5 years period...
December 26, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29287089/discovery-of-novel-orally-bioavailable-antileishmanial-compounds-using-phenotypic-screening
#20
Diana Ortiz, W Armand Guiguemde, Jared T Hammill, Angela K Carrillo, Yizhe Chen, Michele Connelly, Kayla Stalheim, Carolyn Elya, Alex Johnson, Jaeki Min, Anang Shelat, David C Smithson, Lei Yang, Fangyi Zhu, R Kiplin Guy, Scott M Landfear
Leishmaniasis is a parasitic infection that afflicts approximately 12 million people worldwide. There are several limitations to the approved drug therapies for leishmaniasis, including moderate to severe toxicity, growing drug resistance, and the need for extended dosing. Moreover, miltefosine is currently the only orally available drug therapy for this infection. We addressed the pressing need for new therapies by pursuing a two-step phenotypic screen to discover novel, potent, and orally bioavailable antileishmanials...
December 29, 2017: PLoS Neglected Tropical Diseases
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