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cutanous leishmaniasis

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https://www.readbyqxmd.com/read/28630867/potential-challenges-of-controlling-leishmaniasis-in-sri-lanka-at-a-disease-outbreak
#1
REVIEW
Tharaka Wijerathna, Nayana Gunathilaka, Kithsiri Gunawardana, Wasana Rodrigo
The present works reviewed the existing information on leishmaniasis in Sri Lanka and in other countries, focusing on challenges of controlling leishmaniasis in the country, in an outbreak. Evidence from recent studies suggests that there is a possibility of a leishmaniasis outbreak in Sri Lanka in the near future. Difficulty of early diagnosis due to lack of awareness and unavailability or inadequacy of sensitive tests are two of the main challenges for effective case management. Furthermore, the absence of a proper drug for treatment and lack of knowledge about vector biology, distribution, taxonomy and bionomics, and reservoir hosts make the problem serious...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28630182/study-of-biodistribution-and-in-vivo-anti-leishmanial-activity-of-a-distigmasterylhemisuccinoyl-glycero-phosphocholine-liposome-intercalated-amphotericin-b
#2
Maryam Iman, Zhaohua Huang, Seyedeh Hoda Alavizadeh, Francis C Szoka, Mahmoud R Jaafari
Distigmasterylhemisuccinoyl-sn-glycero-3- phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Our previous study revealed that a liposome-intercalated Amphotericin B prepared from DSHemsPC (DSHemsPC-Lip-AmB) possess excellent colloidal properties and in vitro antifungal and anti-leishmanial activity similar to AmBisome™. The aim of this study was to determine biodistribution and evaluate the anti-leishmanial effects of DSHemsPC-Lip-AmB in Leishmania major-infected BALB/c mice...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28629171/cutaneous-manifestations-of-human-and-murine-leishmaniasis
#3
REVIEW
Breanna M Scorza, Edgar M Carvalho, Mary E Wilson
The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes...
June 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28616411/identification-of-etiologic-agents-of-cutaneous-leishmaniasis-in-palpebral-position-followed-by-effective-therapy
#4
Sedigheh Saberi, Reza Arjmand, Ali Khamesipour, Mohammad Ali Nilforoushzadeh, Shaghayegh Sayareh, Seyed Hossein Hejazi
CONTEXT: Cutaneous Leishmaniasis (CL) is a self-healing lesion but prevention of complications and involvement of vital organs such as palpebra requires proper treatment. AIMS: The main objectives were to detect agents of CL in palpebral region and estimate the proportion of palpebral lesion also possible complications among CL patients in a zoonotic CL endemic area. SETTINGS AND DESIGN: The study was performed from April 2012 to March 2013 in a total of 1613 CL suspected patients by interview and physically exam...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28607026/efficacy-of-a-paromomycin-plus-chloroquine-combination-therapy-in-experimental-cutaneous-leishmaniasis
#5
Gert-Jan Wijnant, Katrien Van Bocxlaer, Vanessa Yardley, Sudaxshina Murdan, Simon Croft
The 4-aminoquinoline chloroquine (CQ) is clinically used in combination with doxycycline to cure chronic Q-fever, as it enhances the activity of the antibiotic against the causative Coxiella burnetii bacteria residing within macrophage phagolysosomes. As there is a similar cellular host-pathogen biology for Leishmania parasites, this study aimed to determine whether such an approach could be also the basis for a new, improved treatment for cutaneous leishmaniasis (CL). We have evaluated the in vitro and in vivo activity of combinations of CQ with standard drugs paromomycin (PM), miltefosine and amphotericin B against Leishmania major and Leishmania mexicana In 72-hour intracellular anti-leishmanial assays, outcomes were variable for different drugs...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28606698/comparative-analyses-of-whole-genome-sequences-of-leishmania-infantum-isolates-from-humans-and-dogs-in-northeastern-brazil
#6
D G Teixeira, G R G Monteiro, D R A Martins, M Z Fernandes, V Macedo-Silva, M Ansaldi, P R P Nascimento, M A Kurtz, J A Streit, M F F M Ximenes, R D Pearson, A Miles, J M Blackwell, M E Wilson, A Kitchen, J E Donelson, J P M S Lima, S M B Jeronimo
The genomic sequences of 20 Leishmania infantum isolates collected in northeastern Brazil were compared with each other and with the available genomic sequences of 29 L. infantum/donovani isolates from Nepal and Turkey. The Brazilian isolates were obtained in the early 1990s or since 2009 from patients with visceral or non-ulcerating cutaneous leishmaniasis, asymptomatic humans, or dogs with visceral leishmaniasis. Two isolates were from the blood and bone marrow of the same visceral leishmaniasis patient. All 20 genomic sequences display 99...
June 10, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28602835/topical-treatment-with-nanoliposomal-amphotericin-b-reduces-early-lesion-growth-but-fails-to-induce-cure-in-an-experimental-model-of-cutaneous-leishmaniasis-caused-by-leishmania-mexicana
#7
Sanjay Varikuti, Steve Oghumu, Noushin Saljoughian, Marissa S Pioso, Bren E Sedmak, Ali Khamesipour, Abhay R Satoskar
Leishmania mexicana infection causes localized skin lesions that can lead to tissue damage and permanent disfigurement if not resolved. Currently, recommended treatments include intravenous administration of Amphotericin B, which is undesirable due to the associated cost and patient burden related to receiving regular injections. In this study, we evaluated the effect of topical treatment with a nanoliposomal formulation of Amphotericin B that is penetrable to the skin (SinaAmphoLeish 0.4%) in mice infected with L...
June 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28602279/an-elisa-immunoassay-employing-a-conserved-leishmania-hypothetical-protein-for-the-serodiagnosis-of-visceral-and-tegumentary-leishmaniasis-in-dogs-and-humans
#8
Ana Maria R S Carvalho, Lourena E Costa, Beatriz C S Salles, Thaís T O Santos, Fernanda F Ramos, Mariana P Lima, Miguel A Chávez-Fumagalli, Bruna T Silvestre, Áquila S B Portela, Bruno M Roatt, Julia A G Silveira, Denise U Gonçalves, Danielle F Magalhães-Soares, Mariana C Duarte, Daniel Menezes-Souza, Eduardo A F Coelho
In the present study, a conserved Leishmania hypothetical protein, namely LiHypA, was evaluated for the serodiagnosis of visceral and tegumentary leishmaniasis in dogs and humans. This protein showed a high amino acid sequence homology between viscerotropic and cutaneotropic Leishmania species. An enzyme-linked immunosorbent assay (ELISA) was developed using the recombinant antigen (rLiHypA), in addition to the A2 protein and two parasite antigenic preparations, which were used as controls. Regarding human diagnosis, results showed that rLiHypA was more sensitive and specific than ELISA-L...
June 8, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28600554/seroconversion-to-lutzomyia-intermedia-linb-13-as-a-biomarker-for-developing-cutaneous-leishmaniasis
#9
Augusto M Carvalho, Kiyoshi F Fukutani, Rohit Sharma, Rebecca P Curvelo, José Carlos Miranda, Aldina Barral, Edgar M Carvalho, Jesus G Valenzuela, Fabiano Oliveira, Camila I de Oliveira
Sand flies inject saliva while feeding in the vertebrate host and anti-saliva antibodies can be used as biomarkers of exposure to Leishmania vectors. We expressed recombinant salivary proteins from Lutzomyia intermedia, a vector of Leishmania braziliensis, and evaluated the seroreactivity in exposed individuals in search for exposure markers. We found a strong correlation among positive serology to recombinant proteins LinB-13, 26, 15, 21 and to salivary proteins: rLinB-13 was the top performing molecule; IgG4 was the most predominant antibody subclass and antibodies to rLinB-13 did not cross react with Lu...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28597089/vosalophen-a-vanadium-complex-with-a-stilbene-derivative-induction-of-apoptosis-autophagy-and-efficiency-in-experimental-cutaneous-leishmaniasis
#10
Patrícia de A Machado, Jessica O F Morais, Gustavo S G Carvalho, Wallace P Lima, Gilson C Macedo, Elizandra A Britta, Celso V Nakamura, Adilson D da Silva, Alexandre Cuin, Elaine S Coimbra
In our previous work, we demonstrated the promising in vitro effect of VOSalophen, a vanadium complex with a stilbene derivative, against Leishmania amazonensis. Its antileishmanial activity has been associated with oxidative stress in L. amazonensis promastigotes and L. amazonensis-infected macrophages. In the present study, the mechanism involved in the death of parasites after treatment with VOSalophen, as well as in vivo effect in the murine model cutaneous leishmaniasis, has been investigated. Promastigotes of L...
June 8, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28597032/-leishmaniasis-diagnosis-and-therapy
#11
REVIEW
E von Stebut
The delayed appearance of a papule after returning from travelling hints towards the diagnosis cutaneous leishmaniasis. Histologically, a granulomatous inflammatory response is seen, and using Giemsa staining, intracellular parasites can be visualized within histiocytes. Polymer chain reaction (PCR) from the tissue or subsequent cultures not only aids in excluding other differential diagnoses, but also in the identification of the causing Leishmania subspecies. The latter is important for the choice of the optimal therapeutic regimen...
June 8, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28593838/attractiveness-of-black-and-white-modified-shannon-traps-to-phlebotomine-sandflies-diptera-psychodidae-in-the-brazilian-amazon-basin-an-area-of-intense-transmission-of-american-cutaneous-leishmaniasis
#12
Andreia Fernandes Brilhante, Márcia Moreira de Ávila, Jailson Ferreira de Souza, Antônio Ralph Medeiros-Sousa, Priscila Bassan Sábio, Marcia Bicudo de Paula, Rodrigo Espindola Godoy, Leonardo Augusto Kohara Melchior, Vânia Lúcia Brandão Nunes, Cristiane de Oliveira Cardoso, Eunice Aparecida Bianchi Galati
In the Amazon region the phlebotomine fauna is considered one of the most diverse in the world. The use of Shannon traps may provide information on the anthropophily of the species and improve the traps' performance in terms of diversity and quantity of insects collected when white and black colored traps are used together. This study sought to verify the attractiveness of the traps to the phlebotomine species of the Brazilian Amazon basin using Shannon traps under these conditions. The insects were collected using two Shannon traps installed side by side, one white and the other black, in a primary forest area of the municipality of Xapuri, Acre, Brazil...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28591265/disseminated-cutaneous-leishmaniasis-caused-by-leishmania-braziliensis-in-southern-brazil
#13
Norberto Assis Membrive, Flávio Jun Kazuma, Thaís Gomes Verzignassi Silveira, Jorge Juarez Vieira Teixeira, Kárin Rosi Reinhold-Castro, Ueslei Teodoro
The authors report a case of disseminated cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis, in a 55 years old patient with 1,119 lesions distributed throughout the body. The patient resides in Sabáudia municipality, North of Paraná State, Southern Brazil, where there was no previous report of this form of leishmaniasis. Treatment with meglumine antimoniate was successful, although the diagnosis was made only five months later.
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28591261/sporotrichoid-leishmaniasis-a-cross-sectional-clinical-epidemiological-and-laboratory-study-in-rio-de-janeiro-state-brazil
#14
Livia Martins Veloso de Carvalho, Maria Inês Fernandes Pimentel, Fátima Conceição-Silva, Érica de Camargo Ferreira E Vasconcellos, Cláudia Maria Valete-Rosalino, Marcelo Rosandiski Lyra, Mariza de Matos Salgueiro, Maurício Naoto Saheki, Maria de Fátima Madeira, Eliame Mouta-Confort, Liliane de Fátima Antonio, Aline Fagundes da Silva, Leonardo Pereira Quintella, Sandro Javier Bedoya-Pacheco, Armando de Oliveira Schubach
Background: Atypical presentations of cutaneous leishmaniasis include sporotrichoid leishmaniasis (SL), which is clinically described as a primary ulcer combined with lymphangitis and nodules and/or ulcerated lesions along its pathway. Aims: To assess the differences between patients with sporotrichoid leishmaniasis and typical cutaneous leishmaniasis (CL). Methods: From January 2004 to December 2010, 23 cases of SL (4.7%) were detected among 494 CL patients diagnosed at a reference center for the disease in Rio de Janeiro State, Brazil...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28591228/a-secondary-wave-of-neutrophil-infiltration-causes-necrosis-and-ulceration-in-lesions-of-experimental-american-cutaneous-leishmaniasis
#15
Alex G Peniche, Diana L Bonilla, Gloria I Palma, Peter C Melby, Bruno L Travi, E Yaneth Osorio
We evaluated the importance of neutrophils in the development of chronic lesions caused by L. Viannia spp. using the hamster as experimental model of American Cutaneous Leishmaniasis (ACL). Neutrophils infiltrated the lesion within the first six hours post-infection. Inhibition of this early infiltration using a polyclonal antibody or cyclophosphamide was associated with transient parasite control but the protective effect vanished when lesions became clinically apparent. At lesion onset (approximately 10 days p...
2017: PloS One
https://www.readbyqxmd.com/read/28587839/leishmaniasis-in-turkey-visceral-and-cutaneous-leishmaniasis-caused-by-leishmania-donovani-in-turkey
#16
Ahmet Özbilgin, Mehmet Harman, Mehmet Karakuş, Aldert Bart, Seray Töz, Özgür Kurt, İbrahim Çavuş, Erdal Polat, Cumhur Gündüz, Tom Van Gool, Yusuf Özbel
In Turkey, the main causative agents are Leishmania tropica (L. tropica) and Leishmania infantum (L. infantum) for cutaneous leishmaniasis (CL) and L. infantum for visceral leishmaniasis (VL). In this study, we investigated leishmaniasis cases caused by L. donovani and established animal models for understanding its tropism in in vivo conditions. Clinical samples (lesion aspirations and bone marrow) obtained from CL/VL patients were investigated using parasitological (smear/NNN) and DNA-based techniques. For species identification, a real time ITS1-PCR was performed using isolates and results were confirmed by hsp70 PCR-N/sequencing and cpb gene PCR/sequencing in order to reveal Leishmania donovani and Leishmania infantum discrimination...
June 3, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28587683/spatial-and-temporal-distribution-of-american-cutaneous-leishmaniasis-in-acre-state-brazil
#17
Leonardo Augusto Kohara Melchior, Andréia Fernandes Brilhante, Francisco Chiaravalloti-Neto
BACKGROUND: Acre has reported the highest incidence of American cutaneous leishmaniasis (ACL) in Brazil in recent years. The present study seeks to identify high and low risk agglomerations of ACL in space and space-time during the period from 2007 to 2013 in Acre, and also to characterize the occurrence of the disease in time and according to sociodemographic variables. METHODS: This is an ecological study, the study population of which consisted of autochthonous ACL cases notified in the municipalities of Acre by an epidemiological surveillance system...
June 7, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28584380/prospective-study-design-conundrum-disease-registry-for-cutaneous-leishmaniasis
#18
Kanica Kaushal
No abstract text is available yet for this article.
May 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28583224/anti-parasitic-effect-of-the-diuretic-and-na-atpase-inhibitor-furosemide-in-cutaneous-leishmaniasis
#19
N Arruda-Costa, D Escrivani, E E Almeida-Amaral, J R Meyer-Fernandes, B Rossi-Bergmann
Leishmania amazonensis promastigotes are known to express furosemide (Lasix®)-sensitive P-type membrane Na+-ATPase. In the present study, furosemide activity was studied in intracellular amastigotes and infected BALB/c mice to investigate its efficacy in cutaneous leishmaniasis (CL). Intracellular parasites, but not macrophages, were found to be sensitive to killing by furosemide (IC50 = 87 µ m vs CC50 ≫ 1000 µ m, respectively). Although furosemide did not induce nitric oxide production or intracellular pH changes in infected macrophages, it led to a significant reactive oxygen species (ROS) burst...
June 6, 2017: Parasitology
https://www.readbyqxmd.com/read/28573235/in-vivo-and-in-vitro-antileishmanial-effects-of-methanolic-extract-from-bark-of-bursera-aptera
#20
O J Nieto-Yañez, A A Resendiz-Albor, P A Ruiz-Hurtado, N Rivera-Yañez, M Rodriguez-Canales, M Rodriguez-Sosa, I Juarez-Avelar, M G Rodriguez-Lopez, M M Canales-Martinez, M A Rodriguez-Monroy
BACKGROUND: Cutaneous leishmaniasis lacks effective and well-tolerated treatments. The current therapies mainly rely on antimonial drugs that are inadequate because of their poor efficacy. Traditional medicine offers a complementary alternative for the treatment of various diseases. Additionally, several plants have shown success as anti-leishmanial agents. Therefore, we sought to evaluate the in vitro and in vivo activity of MEBA against Leishmania mexicana. MATERIALS AND METHODS: Methanolic extract of B...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
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