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https://www.readbyqxmd.com/read/28912658/a-systematic-method-to-detect-the-metabolic-threshold-from-gas-exchange-during-incremental-exercise
#1
Brett A Dolezal, Thomas W Storer, Eric V Neufeld, Stephanie Smooke, Chi-Hong Tseng, Christopher B Cooper
Incremental exercise consists of three domains of exercise intensity demarcated by two thresholds. The first of these thresholds, derived from gas exchange measurements, is defined as the metabolic threshold (V̇O2θ) above which lactate accumulates. Correctly and reliably identified, V̇O2θ is a non-invasive, sub-maximal marker of aerobic function with practical value. This investigation compared variability in selection of V̇O2θ among interpreters with different levels of experience as well as from auto-detection algorithms employed by a commercially available metabolic cart (MC)...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28911803/sensory-overload-and-imbalance-resting-state-vestibular-connectivity-in-ptsd-and-its-dissociative-subtype
#2
Sherain Harricharan, Andrew A Nicholson, Maria Densmore, Jean Théberge, Margaret C McKinnon, Richard W J Neufeld, Ruth A Lanius
BACKGROUND: The vestibular system integrates multisensory information to monitor one's bodily orientation in space, and is influenced by interoceptive awareness. Post-traumatic stress disorder (PTSD) involves typically alterations in interoceptive and bodily self-awareness evidenced by symptoms of hyperarousal, as well as of emotional detachment, including emotional numbing, depersonalization, and derealization. These alterations may disrupt vestibular multisensory integration between the brainstem (vestibular nuclei) and key vestibular cortical regions (parieto-insular vestibular cortex, prefrontal cortex)...
September 11, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28892246/novel-hyperthermia-applicator-system-allows-adaptive-treatment-planning-preliminary-clinical-results-in-tumour-bearing-animals
#3
S Dressel, M-C Gosselin, M H Capstick, E Carrasco, M S Weyland, S Scheidegger, E Neufeld, N Kuster, S Bodis, C Rohrer Bley
Hyperthermia (HT) as an adjuvant to radiation therapy (RT) is a multimodality treatment method to enhance therapeutic efficacy in different tumours. High demands are placed on the hardware and treatment planning software to guarantee adequately planned and applied HT treatments. The aim of this prospective study was to determine the effectiveness and safety of the novel HT system in tumour-bearing dogs and cats in terms of local response and toxicity as well as to compare planned with actual achieved data during heating...
September 11, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28882064/annals-express-development-of-a-novel-fluorescent-activity-assay-for-lecithin-cholesterol-acyltransferase
#4
Toshihiro Sakurai, Akiko Sakurai, Vaisman L Boris, Takafumi Nishida, Edward Neufeld, Stephen J Demosky, Maureen L Sampson, Robert D Shamburek, Lita A Freeman, Alan T Remaley
No abstract text is available yet for this article.
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28871207/optical-flow-based-non-invasive-analysis-of-cardiomyocyte-contractility
#5
Andras Czirok, Dona Greta Isai, Edina Kosa, Sheeja Rajasingh, William Kinsey, Zoltan Neufeld, Johnson Rajasingh
Characterization of cardiomyocyte beat patterns is needed for quality control of cells intended for surgical injection as well as to establish phenotypes in disease modeling or toxicity studies. Optical-flow based analysis of videomicroscopic recordings offer a manipulation-free and efficient characterization of contractile cycles, an important characteristics of cardiomyocyte phenotype. We demonstrate that by appropriate computational analysis of optical flow data one can identify distinct contractile centers and distinguish active cell contractility from passive elastic tissue deformations...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28854532/association-of-intraoperative-changes-in-brain-derived-neurotrophic-factor-and-postoperative-delirium-in-older-adults
#6
J Wyrobek, A LaFlam, L Max, J Tian, K J Neufeld, K M Kebaish, J D Walston, C W Hogue, L H Riley, A D Everett, C H Brown
Background: Delirium is common after surgery, although the aetiology is poorly defined. Brain-derived neurotrophic factor (BDNF) is a neurotrophin important in neurotransmission and neuroplasticity. Decreased levels of BDNF have been associated with poor cognitive outcomes, but few studies have characterized the role of BDNF perioperatively. We hypothesized that intraoperative decreases in BDNF levels are associated with postoperative delirium. Methods: Patients undergoing spine surgery were enrolled in a prospective cohort study...
August 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28838815/standardized-computer-based-organized-reporting-of-eeg-score-second-version
#7
REVIEW
Sándor Beniczky, Harald Aurlien, Jan C Brøgger, Lawrence J Hirsch, Donald L Schomer, Eugen Trinka, Ronit M Pressler, Richard Wennberg, Gerhard H Visser, Monika Eisermann, Beate Diehl, Ronald P Lesser, Peter W Kaplan, Sylvie Nguyen The Tich, Jong Woo Lee, Antonio Martins-da-Silva, Hermann Stefan, Miri Neufeld, Guido Rubboli, Martin Fabricius, Elena Gardella, Daniella Terney, Pirgit Meritam, Tom Eichele, Eishi Asano, Fieke Cox, Walter van Emde Boas, Ruta Mameniskiene, Petr Marusic, Jana Zárubová, Friedhelm C Schmitt, Ingmar Rosén, Anders Fuglsang-Frederiksen, Akio Ikeda, David B MacDonald, Kiyohito Terada, Yoshikazu Ugawa, Dong Zhou, Susan T Herman
Standardized terminology for computer-based assessment and reporting of EEG has been previously developed in Europe. The International Federation of Clinical Neurophysiology established a taskforce in 2013 to develop this further, and to reach international consensus. This work resulted in the second, revised version of SCORE (Standardized Computer-based Organized Reporting of EEG), which is presented in this paper. The revised terminology was implemented in a software package (SCORE EEG), which was tested in clinical practice on 12,160 EEG recordings...
August 9, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28838751/effects-of-a-parenting-program-among-women-who-began-childbearing-as-adolescents-and-young-adults
#8
Rose M C Kagawa, Julianna Deardorff, Armando García-Guerra, Heather A Knauer, Lourdes Schnaas, Lynnette M Neufeld, Lia C H Fernald
PURPOSE: The purpose of the study was to examine whether access to an at-scale, group-based parenting education program ("Educación Inicial") had differential effects on parenting behaviors and child cognitive development according to mother's age at the birth of her first child, with a focus on adolescent mothers in rural Mexico. METHODS: This was a secondary analysis of a cluster-randomized controlled trial (n = 728 households, n = 106 communities). We conducted intent-to-treat analyses and examined the interaction between treatment group and mother's age at first birth...
August 21, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28836726/dynamic-causal-modeling-in-ptsd-and-its-dissociative-subtype-bottom-up-versus-top-down-processing-within-fear-and-emotion-regulation-circuitry
#9
Andrew A Nicholson, Karl J Friston, Peter Zeidman, Sherain Harricharan, Margaret C McKinnon, Maria Densmore, Richard W J Neufeld, Jean Théberge, Frank Corrigan, Rakesh Jetly, David Spiegel, Ruth A Lanius
OBJECTIVE: Posttraumatic stress disorder (PTSD) is associated with decreased top-down emotion modulation from medial prefrontal cortex (mPFC) regions, a pathophysiology accompanied by hyperarousal and hyperactivation of the amygdala. By contrast, PTSD patients with the dissociative subtype (PTSD + DS) often exhibit increased mPFC top-down modulation and decreased amygdala activation associated with emotional detachment and hypoarousal. Crucially, PTSD and PTSD + DS display distinct functional connectivity within the PFC, amygdala complexes, and the periaqueductal gray (PAG), a region related to defensive responses/emotional coping...
August 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28835678/altered-cortical-brain-activity-in-end-stage-liver-disease-assessed-by-multi-channel-near-infrared-spectroscopy-associations-with-delirium
#10
Atsushi Yoshimura, Carrie Goodson, Jordan T Johns, Maxwell M Towe, Esme S Irvine, Nada A Rendradjaja, Laura K Max, Andrew LaFlam, Emily C Ledford, Julia Probert, Zoë Tieges, David H Edwin, Alasdair M J MacLullich, Charles W Hogue, Martin A Lindquist, Ahmet Gurakar, Karin J Neufeld, Atsushi Kamiya
Delirium is a common and serious psychiatric syndrome caused by an underlying medical condition. It is associated with significant mortality and increased healthcare resource utilization. There are few biological markers of delirium, perhaps related to the etiologic heterogeneity of the syndrome. Functional near-infrared spectroscopy (fNIRS) is an optical topography system to measure changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the cerebral cortex. We examined whether altered cortical brain activity in delirious patients with end stage liver disease (ESLD) is detected by fNIRS...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827313/spermine-inhibits-vibrio-cholerae-biofilm-formation-through-the-nsps-mbaa-polyamine-signaling-system
#11
Richard C Sobe, Whitney G Bond, Caitlin K Wotanis, Josiah P Zayner, Marybeth A Burriss, Nicolas Fernandez, Eric L Bruger, Christopher M Waters, Howard S Neufeld, Ece Karatan
The aquatic bacterium and human intestinal pathogen, Vibrio cholerae, senses and responds to a variety of environment-specific cues to regulate biofilm formation. Specifically, the polyamines norspermidine and spermidine enhance and repress V. cholerae biofilm formation, respectively. These effects are relevant for understanding V. cholerae pathogenicity and are mediated through the periplasmic binding protein, NspS, and the transmembrane c-di-GMP phosphodiesterase MbaA. However, the levels of spermidine required to inhibit biofilm formation through this pathway are unlikely to be encountered by V...
August 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28822927/comparative-ozone-responses-of-cutleaf-coneflowers-rudbeckia-laciniata-var-digitata-var-ampla-from-rocky-mountain-and-great-smoky-mountains-national-parks-usa
#12
Howard S Neufeld, Jennifer Johnson, Robert Kohut
Cutleaf coneflower (Rudbeckia laciniata L. var. digitata) is native to Great Smoky Mountains National Park (GRSM) and an ozone bioindicator species. Variety ampla, whose ozone sensitivity is less well known, is native to Rocky Mountain National Park (ROMO). In the early 2000s, researchers found putative ozone symptoms on var. ampla and rhizomes were sent to Appalachian State University to verify that the symptoms were the result of ozone exposure. In 2011, potted plants were exposed to ambient ozone from May to August...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28815880/immunogenicity-efficacy-and-safety-of-nuwiq-%C3%A2-human-cl-rhfviii-in-previously-untreated-patients-with-severe-haemophilia-a-interim-results-from-the-nuprotect-study
#13
R J Liesner, M Abashidze, O Aleinikova, C Altisent, M J Belletrutti, A Borel-Derlon, M Carcao, H Chambost, A K C Chan, L Dubey, J Ducore, N A Fouzia, M Gattens, Y Gruel, B Guillet, N Kavardakova, M El Khorassani, A Klukowska, T Lambert, S Lohade, M Sigaud, V Turea, J K M Wu, V Vdovin, A Pavlova, M Jansen, L Belyanskaya, O Walter, S Knaub, E J Neufeld
INTRODUCTION: Nuwiq(®) (Human-cl rhFVIII) is a fourth generation recombinant FVIII, produced in a human cell line, without chemical modification or protein fusion. No inhibitors developed in studies with Nuwiq(®) in 201 previously treated patients with haemophilia A (HA). The immunogenicity, efficacy and safety of Nuwiq(®) in previously untreated patients (PUPs) with severe HA are being assessed in the ongoing NuProtect study. METHODS: The study, conducted across 38 centres worldwide, is evaluating 110 true PUPs of all ages and ethnicities enrolled for study up to 100 exposure days (EDs) or 5 years maximum...
August 16, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28814832/combinatorial-and-sequential-delivery-of-gemcitabine-and-oseltamivir-phosphate-from-implantable-poly-d-l-lactic-co-glycolic-acid-cylinders-disables-human-pancreatic-cancer-cell-survival
#14
Stephanie Allison Logan, Amanda J Brissenden, Myron R Szewczuk, Ronald J Neufeld
Combination therapies against multiple targets are currently being developed to prevent resistance to a single chemotherapeutic agent and to extirpate pre-existing resistance in heterogeneous cancer cells in tumors due to selective pressure from the single agent. Gemcitabine (GEM), a chemotherapeutic agent, is the current standard of care for patients with pancreatic cancer. Patients with pancreatic cancer receiving GEM have a low progression-free survival. Given the poor response rate to GEM, cancer cells are known to develop rapid resistance to this drug...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28796503/effect-of-processing-on-the-in-vitro-and-in-vivo-protein-quality-of-yellow-and-green-split-peas-pisum-sativum
#15
Matthew G Nosworthy, Adam J Franczyk, Gerardo Medina, Jason Neufeld, Paulyn Appah, Alphonsus Utioh, Peter Frohlich, James D House
In order to determine the effect of extrusion, baking, and cooking on the protein quality of yellow and green split peas, a rodent bioassay was conducted and compared to an in vitro method of protein quality determination. The Protein Digestibility-Corrected Amino Acid Score (PDCAAS) of green split peas (71.4%) was higher than that of yellow split peas (67.8%), on average. Similarly, the average Digestible Indispensable Amino Acid Score (DIAAS) of green split peas (69%) was higher than that of yellow split peas (67%)...
September 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28781118/delirium-phenomenology-and-beyond
#16
EDITORIAL
Karin Neufeld
No abstract text is available yet for this article.
July 12, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28761935/the-skin-microbiome-of-cohabiting-couples
#17
Ashley A Ross, Andrew C Doxey, Josh D Neufeld
Distinct microbial communities inhabit individuals as part of the human skin microbiome and are continually shed to the surrounding environment. Microbial communities from 17 skin sites of 10 sexually active cohabiting couples (20 individuals) were sampled to test whether cohabitation impacts an individual's skin microbiome, leading to shared skin microbiota among partner pairs. Amplified 16S rRNA genes of bacteria and archaea from a total of 340 skin swabs were analyzed by high-throughput sequencing, and the results demonstrated that cohabitation was significantly associated with microbial community composition, although this association was greatly exceeded by characteristics of body location and individuality...
July 2017: MSystems
https://www.readbyqxmd.com/read/28761079/alterations-in-resting-state-connectivity-along-the-autism-trait-continuum-a-twin-study
#18
J Neufeld, R Kuja-Halkola, K Mevel, É Cauvet, P Fransson, S Bölte
Autism spectrum disorder (ASD) has been found to be associated with alterations in resting state (RS) functional connectivity, including areas forming the default mode network (DMN) and salience network (SN). However, insufficient control for confounding genetic and environmental influences and other methodological issues limit the generalizability of previous findings. Moreover, it has been hypothesized that ASD might be marked by early hyper-connectivity followed by later hypo-connectivity. To date, only a few studies have explicitly tested age-related influences on RS connectivity alterations in ASD...
August 1, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28760007/double-fortified-salt-intervention-improved-iron-intake-but-not-energy-and-other-nutrient-intakes-in-female-tea-plantation-workers-from-west-bengal-india
#19
Sudha Venkatramanan, Grace Marquis, Lynnette Neufeld, Michael Wenger, Laura Murray-Kolb, Gregory Reinhart, Jere Haas
BACKGROUND: Iron deficiency is a global public health concern and has implications on the health status of women in reproductive age. OBJECTIVE: We hypothesized that improving iron intake with double fortified salt would improve food intake, resulting in higher energy, nutrient intakes, and weight indicators of female tea plantation workers. METHODS: In this randomized double-masked study, the participants (n = 245) were assigned to receive salt double fortified with iron and iodine (DFS; treatment) or salt fortified with iodine (control) and followed for 7...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28752639/perioperative-management-of-haemophilia-b-a-critical-appraisal-of-the-evidence-and-current-practices
#20
REVIEW
E J Neufeld, L Solimeno, D Quon, C Walsh, S Seremetis, D Cooper, N N Iyer, C S Hoxer, P Giangrande
BACKGROUND: While there is substantial literature addressing the principles of general management of haemophilia, literature on perioperative management of haemostasis is scarce. OBJECTIVE: The aim of this study was to better understand perioperative management among congenital haemophilia B patients (without inhibitors) and to gain insights into real-world surgical practices. METHOD: A systematic literature review, with an emphasis on haemophilia B, was conducted using EMBASE(®) , Medline(®) and the Cochrane Library...
July 27, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
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