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https://www.readbyqxmd.com/read/29225106/tannic-acid-ta-a-molecular-tool-for-chelating-and-imaging-labile-iron
#1
Isara Phiwchai, Wiphawee Yuensook, Natsaree Sawaengsiriphon, Saowalak Krungchanuchat, Chalermchai Pilapong
This report presents the potential utilization of tannic acid (TA) as a natural iron chelator. TA is capable of binding with small ferric complexes without competitive binding with endogenous iron-containing molecules such as ferritin and transferrin. It was observed that the extracellular iron binding of TA resulted in the formation of self-assembled Fe3+-TA complexes, which were then taken up by HepG2 cells via phagocytosis pathway with autophagy-inducing properties. Obviously, TA was found to inhibit iron-induced HepG2 cell growth...
December 7, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29225034/cytosolic-iron-sulfur-assembly-is-evolutionarily-tuned-by-a-cancer-amplified-ubiquitin-ligase
#2
Jenny L Weon, Seung Wook Yang, Patrick Ryan Potts
The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) pathway functions to incorporate inorganic Fe-S cofactors into a variety of proteins, including several DNA repair enzymes. However, the mechanisms regulating the CIA pathway are unknown. We describe here that the MAGE-F1-NSE1 E3 ubiquitin ligase regulates the CIA pathway through ubiquitination and degradation of the CIA-targeting protein MMS19. Overexpression or knockout of MAGE-F1 altered Fe-S incorporation into MMS19-dependent DNA repair enzymes, DNA repair capacity, sensitivity to DNA-damaging agents, and iron homeostasis...
November 30, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29223642/fighting-resilient-cancers-with-iron
#3
Jonathan J Chen, Lorenzo Galluzzi
Tumor progression and resistance to treatment are often accompanied by the polarization of malignant cells towards a mesenchymal or poorly differentiated state. Such a transition generates an accrued vulnerability to the induction of ferroptosis, potentially paving the way to novel therapeutic strategies for targeting residual disease in patients with cancer.
December 6, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/29220122/expression-profile-analysis-of-long-noncoding-rna-in-acute-myeloid-leukemia-by-microarray-and-bioinformatics
#4
Yuandong Feng, Ying Shen, Hongli Chen, Xiaman Wang, Ru Zhang, Yue Peng, Xiaoru Lei, Tian Liu, Jing Liu, Liufang Gu, Fangxia Wang, Yun Yang, Ju Bai, Jianli Wang, Wanhong Zhao, Aili He
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, which are involved in tumorigenesis and play a key role in cancer progression. To determine whether lncRNAs are involved in acute myeloid leukemia (AML), we analyzed the expression profile of lncRNAs and mRNAs in AML. 5 pairs of AML patients and iron deficiency anemia (IDA) controls were screened by microarray. Through co-expression analysis, differently expressed transcripts were done into modules, and lncRNAs got the functional annotations...
December 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/29219922/multimodal-prehabilitation-programs-as-a-bundle-of-care-in-gastrointestinal-cancer-surgery-a-systematic-review
#5
Vladimir Bolshinsky, Michael H-G Li, Hilmy Ismail, Kate Burbury, Bernhard Riedel, Alexander Heriot
BACKGROUND: Prehabilitation reflects a proactive process of preoperative optimization undertaken between cancer diagnosis and definitive surgical treatment, with the intent of improving physiological capacity to withstand the major insult of surgery. Prehabilitation before GI cancer surgery is currently not widely adopted, and most research has focused on unimodal interventions such as exercise therapy, nutritional supplementation, and hematinic optimization. A review of the existing literature was undertaken to investigate the impact of multimodal prehabilitation programs as a "bundle of care...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29212168/nrf2-induces-cisplatin-resistance-via-suppressing-the-iron-export-related-gene-slc40a1-in-ovarian-cancer-cells
#6
Jianfa Wu, Lingjie Bao, Zhenbo Zhang, Xiaofang Yi
Induction of Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) has been demonstrated to be involved in cisplatin resistance in ovarian cancer. Solute carrier family 40 member 1 (SLC40A1) is an iron exporter, which possesses many putative Nrf2 binding sites. Here we hypothesize that it may be a possible downstream gene of Nrf2. Elevated level of Nrf2 and reduced level of SLC40A1 were found in cisplatin-resistant ovarian cancer cells as compared with cisplatin-sensitive ovarian cancer cells. Exogenous knockdown of Nrf2 leaded to increased expression of SLC40A1...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210434/nano-confinement-driven-enhanced-magnetic-relaxivity-of-spions-for-targeted-tumor-bioimaging
#7
Tuyen Duong Thanh Nguyen, Arunkumar Pitchaimani, Colin Ferrel, Ravindra Thakkar, Santosh Aryal
Superparamagnetic iron oxide nanoparticles (SPIONs) are highly biocompatible and have a versatile synthetic technique based on coprecipitation, reduction-precipitation, and hydrothermal methods, where Fe3+ and Fe2+ react in aqueous solutions; both these ions are present in our body and have clear metabolic pathways; therefore, they have attracted extensive research interest and development in the field of diagnostic imaging and therapy. However, most SPION-based clinical diagnostic contrast agents are discontinued due to severe pain, low transverse magnetic relaxivity range of 80-180 mM-1 s-1, shorter circulation half-life, and lack of disease specificity...
December 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/29207552/hydroxyapatite-coated-iron-oxide-nanoparticles-a-promising-nanomaterial-for-magnetic-hyperthermia-cancer-treatment
#8
Sudip Mondal, Panchanathan Manivasagan, Subramaniyan Bharathiraja, Madhappan Santha Moorthy, Van Tu Nguyen, Hye Hyun Kim, Seung Yun Nam, Kang Dae Lee, Junghwan Oh
Targeting cancer cells without injuring normal cells is the prime objective in treatment of cancer. In this present study, solvothermal and wet chemical precipitation techniques were employed to synthesize iron oxide (IO), hydroxyapatite (HAp), and hydroxyapatite coated iron oxide (IO-HAp) nanoparticles for magnetic hyperthermia mediated cancer therapy. The synthesized well dispersed spherical IO-HAp nanoparticles, magnetite, and apatite phases were confirmed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and Field emission transmission electron microscopy (FETEM) with Energy Dispersive X-ray spectroscopy (EDS)...
December 4, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29205944/iron-oxide-nanoparticles-innovative-tool-in-cancer-diagnosis-and-therapy
#9
REVIEW
Pavla Martinkova, Martin Brtnicky, Jindrich Kynicky, Miroslav Pohanka
Although cancer is one of the most dangerous and the second most lethal disease in the world, current therapy including surgery, chemotherapy, radiotherapy, etc., is highly insufficient not in the view of therapy success rate or the amount of side effects. Accordingly, procedures with better outcomes are highly desirable. Iron oxide nanoparticles (IONPs) present an innovative tool-ideal for innovation and implementation into practice. This review is focused on summarizing some well-known facts about pharmacokinetics, toxicity, and the types of IONPs, and furthermore, provides a survey of their use in cancer diagnosis and therapy...
December 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29205621/multiparametric-characterization-of-response-to-anti-angiogenic-therapy-using-uspio-contrast-enhanced-mri-in-combination-with-dynamic-contrast-enhanced-mri
#10
Jana Kim, Eugene Kim, Leslie R Euceda, Dan E Meyer, Karina Langseth, Tone F Bathen, Siver A Moestue, Else Marie Huuse
BACKGROUND: Steady state susceptibility contrast (SSC)-MRI provides information on vascular morphology but is a rarely used method. PURPOSE: To investigate the utility of the ultrasmall superparamagnetic iron oxide particles (USPIOs) GEH121333 for measuring tumor response to bevacizumab and compare this with gadolinium-based DCE-MRI. STUDY TYPE: Prospective preclinical animal model study. ANIMAL MODEL: Mice bearing subcutaneous TOV-21G human ovarian cancer xenografts treated with bevacizumab (n = 9) or saline (n = 9)...
December 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29203959/cancer-cell-specific-mitochondrial-reactive-oxygen-species-promote-non-heme-iron-uptake-and-enhance-the-proliferation-of-gastric-epithelial-cancer-cell
#11
Hiromu Ito, Hiromi Kurokawa, Aki Hirayama, Hiroko P Indo, Hideyuki J Majima, Hirofumi Matsui
Iron is an essential nutrient for life and is involved in many important processes such as oxygen transport and DNA synthesis. However, excess amounts of iron can cause carcinogenesis by producing reactive oxygen species. Thus, the cellular transport of iron must be tightly regulated. In the human body, iron may be present as heme or non-heme iron. The mechanisms governing the cellular transport of these forms have not been clearly elucidated. We previously reported that the expression of an important heme transporter, heme carrier protein 1 was regulated by cancer-specific reactive oxygen species derived from mitochondria...
November 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29202474/adhfe1-is-a-breast-cancer-oncogene-and-induces-metabolic-reprogramming
#12
Prachi Mishra, Wei Tang, Vasanta Putluri, Tiffany H Dorsey, Feng Jin, Fang Wang, Donewei Zhu, Lauren Amable, Tao Deng, Shaofei Zhang, J Keith Killian, Yonghong Wang, Tsion Z Minas, Harry G Yfantis, Dong H Lee, Arun Sreekumar, Michael Bustin, Wei Liu, Nagireddy Putluri, Stefan Ambs
Metabolic reprogramming in breast tumors is linked to increases in putative oncogenic metabolites that may contribute to malignant transformation. We previously showed that accumulation of the oncometabolite, 2-hydroxyglutarate (2HG), in breast tumors was associated with MYC signaling, but not with isocitrate dehydrogenase (IDH) mutations, suggesting a distinct mechanism for increased 2HG in breast cancer. Here, we determined that D-2HG is the predominant enantiomer in human breast tumors and show that the D-2HG-producing mitochondrial enzyme, alcohol dehydrogenase, iron-containing protein 1 (ADHFE1), is a breast cancer oncogene that decreases patient survival...
November 27, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29200260/tuning-the-distance-of-rattle-shaped-ionp-shell-in-shell-nanoparticles-for-magnetically-targeted-photothermal-therapy-in-the-second-near-infrared-window
#13
Ming-Fong Tsai, Chin Hsu, Chen-Sheng Yeh, Yu-Jen Hsiao, Chia-Hao Su, Li Fang Wang
Construction of multifunctional nanoparticles (NPs) with near-infrared (NIR) plasmonic responses is considered a versatile and multifaceted platform for several biomedical applications. Herein, a double layer of Au/Ag alloy on the surface of truncated octahedral iron oxide NPs (IONPs) was prepared and the distance between the layers was controlled to exhibit broad and strong NIR absorption. The rattle-shaped IONP@shell-in-shell nanostructure showed light-response to the NIR biological window from 650 to 1300 nm for photothermal therapy (PTT) and magnetic guidance for hyperthermia and magnetic resonance imaging (MRI) diagnosis...
December 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29197070/the-role-of-oxidative-stress-in-friedreich-s-ataxia
#14
REVIEW
Federica Lupoli, Tommaso Vannocci, Giovanni Longo, Neri Niccolai, Annalisa Pastore
Oxidative stress and increase in the levels of free radicals are important markers associated with several pathologies, including Alzheimer's disease, cancer and diabetes. Friedreich's ataxia is an excellent paradigmatic example of a disease in which oxidative stress plays an important, albeit not completely understood, role. Friedreich's ataxia is a rare genetic neurodegenerative disease which involves partial silencing of frataxin, a small mitochondrial protein completely ignored before being linked to Friedreich's ataxia...
December 2, 2017: FEBS Letters
https://www.readbyqxmd.com/read/29193231/using-mri-cell-tracking-to-monitor-immune-cell-recruitment-in-response-to-a-peptide-based-cancer-vaccine
#15
Marie-Laurence Tremblay, Christa Davis, Chris V Bowen, Olivia Stanley, Cathryn Parsons, Genevieve Weir, Mohan Karkada, Marianne M Stanford, Kimberly D Brewer
PURPOSE: MRI cell tracking can be used to monitor immune cells involved in the immunotherapy response, providing insight into the mechanism of action, temporal progression of tumor growth, and individual potency of therapies. To evaluate whether MRI could be used to track immune cell populations in response to immunotherapy, CD8+ cytotoxic T cells, CD4+ CD25+ FoxP3+ regulatory T cells, and myeloid-derived suppressor cells were labeled with superparamagnetic iron oxide particles. METHODS: Superparamagnetic iron oxide-labeled cells were injected into mice (one cell type/mouse) implanted with a human papillomavirus-based cervical cancer model...
November 29, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29192767/a-trojan-horse-for-light-triggered-bifurcated-production-of-singlet-oxygen-and-fenton-reactive-iron-within-cancer-cells
#16
Daniela Cioloboc, Christopher Kennedy, Emily N Boice, Emily R Clark, Donald M Kurtz
Traditional photodynamic therapy for cancer relies on dye-photosensitized generation of singlet oxygen. However, therapeutically effective singlet oxygen generation requires well-oxygenated tissues, whereas many tumor environments tend to be hypoxic. We describe a platform for targeted enhancement of photodynamic therapy that produces singlet oxygen in oxygenated environments and hydroxyl radical, which is typically regarded as the most toxic reactive oxygen species, in hypoxic environments. The 24-subunit iron storage protein bacterioferritin (Bfr) has the unique property of binding 12 heme groups in its protein shell...
December 1, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29190945/serum-ferritin-and-primary-lung-cancer
#17
Zhongqing Chen, Bo Zhu, Chao Ou, Yuxuan Li
Existing research yields conflicting results regarding the relation between iron deficiency and high serum ferritin (SF) levels in primary lung cancer patients. We investigated the concentrations of SF, hemoglobin (Hb) and transferrin (TRF) in 569 male primary lung cancer patients and 252 female primary lung cancer patients. We grouped the subjects according to gender, smoking status, menopausal status, pathological type, stage, and TNM stage. The levels of SF and TRF were correlated with T stage in male patients (p<0...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29180001/effect-of-the-fe2-chelation-by-2-2-dipyridyl-in-the-doxorubicin-induced-lethality-in-breast-tumor-cell-lines
#18
Jéssica R Bernardes, Caroline C de Faria, Iris S Andrade, Andrea Claudia Freitas Ferreira, Denise P Carvalho, Alvaro C Leitão, Tatiana A M de Alencar, Rodrigo S Fortunato
Breast cancer cells may exhibit changes in iron homeostasis, which results in increased labile iron pool (LIP) levels. Several studies highlight the crucial role of high LIP levels in the maintenance of tumor cell physiology. Iron chelators have been tested in anticancer therapy in combination with chemotherapeutic agents, to improve drug efficacy. Thus, the aim of this study was to evaluate the effect of 2,2'-dipyridyl (DIP), a Fe2+ chelator, in combination with doxorubicin (DOX) in breast tumor cells. The maximum concentration of DIP that did not significantly reduce the viability of MDA-MB-231 cells was 10μM and for MCF-7 cells was 50μM...
November 24, 2017: Life Sciences
https://www.readbyqxmd.com/read/29175080/targeted-iron-nanoparticles-with-platinum-iv-prodrugs-and-anti-ezh2-sirna-show-great-synergy-in-combating-drug-resistance-in%C3%A2-vitro-and-in%C3%A2-vivo
#19
Chang Yu, Binbin Ding, Xinyang Zhang, Xiaoran Deng, Kerong Deng, Ziyong Cheng, Bengang Xing, Dayong Jin, Ping'an Ma, Jun Lin
Resistance to platinum agents is challenging in cancer treatment with platinum drugs. Such resistant cells prevent effective platinum accumulation intracellular and alter cellular adaptations to survive from cytotoxicity by regulating corresponding proteins expression. Ideal therapeutics should combine resolution to these pump and non-pump relevant resistance of cancer cells to achieve high efficacy and low side effect. Fe3O4 nanocarrier loaded with drugs could enter cells in a more efficient endocytosis manner which circumvents pump-relevant drug resistance...
November 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/29172705/expression-of-iron-related-proteins-in-feline-and-canine-mammary-gland-reveals-unexpected-accumulation-of-iron
#20
O Marques, A Canadas, F Faria, E Oliveira, I Amorim, F Seixas, A Gama, A Lobo-da-Cunha, B Martins da Silva, G Porto, C Lopes
Dysregulation of cellular iron homeostasis in human breast cancer is reflected by the altered expression of regulatory proteins. The expressions of iron-related proteins in the mammary glands of cats and dogs have not been assessed. We evaluated the expressions of ferritin, ferroportin, hepcidin and transferrin receptor 1 in benign and malignant mammary gland lesions in cats and dogs. Iron deposition was detected using Perls' Prussian blue staining. We found no major differences in the expression of iron-related proteins between benign and malignant mammary gland lesions in either cats or dogs; however, these species exhibited accumulation of iron in benign lesions...
November 27, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
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