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https://www.readbyqxmd.com/read/29046993/synthesis-and-in-vitro-performance-of-polypyrrole-coated-iron-platinum-nanoparticles-for-photothermal-therapy-and-photoacoustic-imaging
#1
Thi Tuong Vy Phan, Nhat Quang Bui, Madhappan Santha Moorthy, Kang Dae Lee, Junghwan Oh
Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron-platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as novel agents for combined photothermal therapy (PTT) and PAI. The obtained PPy-coated FePt NPs (FePt@PPy NPs) showed excellent biocompatibility, photothermal stability, and high near-infrared (NIR) absorbance for the combination of PTT and PAI...
October 18, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29039917/multifunctional-theranostic-nanoparticles-based-on-exceedingly-small-magnetic-iron-oxide-nanoparticles-for-t1-weighted-magnetic-resonance-imaging-and-chemotherapy
#2
Zheyu Shen, Tianxiang Chen, Xuehua Ma, Wenzhi Ren, Zijian Zhou, Guizhi Zhu, Ariel Zhang, Yijing Liu, Jibin Song, Zihou Li, Huimin Ruan, Wenpei Fan, Lisen Lin, Jeeva Munasinghe, Xiaoyuan Chen, Aiguo Wu
The recently emerged exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) (<5 nm) are promising T1-weighted contrast agents for magnetic resonance imaging (MRI) due to their good biocompatibility compared with Gd-chelates. However, the best particle size of ES-MIONs for T1 imaging is still unknown because the synthesis of ES-MIONs with precise size control to clarify the relationship between the r1 (or r2/r1) and the particle size remains a challenge. In this study, we synthesized ES-MIONs with seven different sizes below 5 nm and found that 3...
October 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/29039462/antiproliferative-activity-of-di-2-pyridylhydrazone-dithiocarbamate-acetate-partly-involved-in-p53-mediated-apoptosis-and-autophagy
#3
Tingting Wang, Youxun Liu, Yun Fu, Tengfei Huang, Yun Yang, Shaoshan Li, Changzheng Li
Cancer cells have higher demand of iron and copper ions for growth, disturbing the metal's homeostasis can inhibit proliferation of cancer cell. Dithiocarbamates possessing excellent metal chelating ability and antitumor activity are considered as candidates in chelation therapy, however, their antitumor molecular mechanisms remain to be elucidated. In the present study, a dithiocarbamate derivative, di-2-pyridylhydrazone dithiocarbamate s-acetic acid (DpdtaA) was prepared to address the issue whether the molecular mechanism behind biological behavior showed by dithiocarbamate was p53 mediated...
October 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29038584/dual-drug-containing-core-shell-nanoparticles-for-lung-cancer-therapy
#4
Jyothi U Menon, Aneetta Kuriakose, Roshni Iyer, Elizabeth Hernandez, Leah Gandee, Shanrong Zhang, Masaya Takahashi, Zhang Zhang, Debabrata Saha, Kytai T Nguyen
Late-stage diagnosis of lung cancer occurs ~95% of the time due to late manifestation of its symptoms, necessitating rigorous treatment following diagnosis. Existing treatment methods are limited by lack of specificity, systemic toxicity, temporary remission, and radio-resistance in lung cancer cells. In this research, we have developed a folate receptor-targeting multifunctional dual drug-loaded nanoparticle (MDNP) containing a poly(N-isopropylacrylamide)-carboxymethyl chitosan shell and poly lactic-co-glycolic acid (PLGA) core for enhancing localized chemo-radiotherapy to effectively treat lung cancers...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038383/biological-effects-of-mri-contrast-agents-gadolinium-retention-potential-mechanisms-and-a-role-for-phosphorus
#5
REVIEW
Joel Garcia, Stephen Z Liu, Angelique Y Louie
No discussion of challenges for chemistry in molecular imaging would be complete without addressing the elephant in the room-which is that the purest of chemical compounds needs to interact with a biological system in a manner that does not perturb normal biology while still providing efficacious feedback to assist in diagnosis of disease. In the past decade, magnetic resonance imaging (MRI) agents long considered inert have produced adverse effects in certain patient populations under certain treatment regimens...
November 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29035540/targeted-clinical-nanoparticles-for-precision-cancer-therapy-based-on-disease-specific-molecular-inflection-points
#6
Charalambos Kaittanis, Alexander Bolaender, Barney Yoo, Nilesh Shah, Ouathek Ouerfelli, Jan Grimm
ional approaches based on clinical modular nanoplatforms are needed, in order to treat solid cancers according to their discrete molecular features. In the present study, we show that the clinical nanopharmaceutical Ferumoxytol, which consists of a glucose-based coat surrounding an iron oxide core, could identify molecular characteristics of prostate cancer, corresponding to unique phases of the disease continuum. By affixing a targeting probe for the prostate-specific membrane antigen on its surface, the nanopharmaceutical was able to assess the functional state of the androgen receptor pathway via MRI, guiding therapy and delivering it with the same clinical nanoparticle...
October 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/29035507/sequential-delivery-of-doxorubicin-and-zoledronic-acid-to-breast-cancer-cells-by-cb-7-modified-iron-oxide-nanoparticles
#7
Farah Benyettou, Marwa Alhashimi, Matthew O'Connor, Renu Pasricha, Jérémy Brandel, Hassan Trabousli, Javed Mazher, John-Carl Olsen, Ali Trabolsi
Drug-loaded magnetic nanoparticles were synthesized and used for the sequential delivery of the anti-resorptive agent zoledronic acid (Zol) and the cytotoxic drug doxorubicin (Dox) to breast cancer cells (MCF-7). Zol was attached to bare iron oxide nanoparticles (IONPs) via phosphonate coordination to form Z-NPs. The unbound imidazole of Zol was then used to complex the organic macrocycle CB[7] to obtain CZ-NPs. Dox was then complexed to the CZ-NPs to form the fully loaded particles (DCZ-NPs), which were stable in solution at 37 ºC and physiological pH (7...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29033565/double-receptor-targeting-multifunctional-iron-oxide-nanoparticles-drug-delivery-system-for-the-treatment-and-imaging-of-prostate-cancer
#8
Md Shakir Uddin Ahmed, Ahmad Bin Salam, Clayton Yates, Kyle Willian, Jesse Jaynes, Timothy Turner, Mohamed O Abdalla
As an alternative therapeutic treatment to reduce or eliminate the current side effects associated with advanced prostate cancer (PCa) chemotherapy, a multifunctional double-receptor-targeting iron oxide nanoparticles (IONPs) (luteinizing hormone-releasing hormone receptor [LHRH-R] peptide- and urokinase-type plasminogen activator receptor [uPAR] peptide-targeted iron oxide nanoparticles, LHRH-AE105-IONPs) drug delivery system was developed. Two tumor-targeting peptides guided this double-receptor-targeting nanoscale drug delivery system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29032246/transcriptional-regulation-of-the-cyclin-dependent-kinase-inhibitor-p21-cip1-waf1-by-the-chelator-dp44mt
#9
Rayan Saleh Moussa, Zaklina Kovacevic, Dong-Hun Bae, Darius J R Lane, Des R Richardson
BACKGROUND: The cyclin-dependent kinase inhibitor, p21, is well known for its role in cell cycle arrest. Novel anti-cancer agents that deplete iron pools demonstrate marked anti-tumor activity and are also active in regulating p21 expression. These agents induce p21 mRNA levels independently of the tumor suppressor, p53, and differentially regulate p21 protein expression depending on the cell-type. Several chelators, including an analogue of the potent anti-tumor agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), have entered clinical trials, and thus, their molecular mechanism of action is crucial to assess...
October 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29030222/vascular-changes-in-tumors-resistant-to-a-vascular-disrupting-nanoparticle-treatment
#10
Shweta Sharma, Aman P Mann, Tarmo Mölder, Venkata Ramana Kotamraju, Robert Mattrey, Tambet Teesalu, Erkki Ruoslahti
Anti-angiogenic and vascular disrupting therapies rely on the dependence of tumors on new blood vessels to sustain tumor growth. We previously reported a potent vascular disrupting agent, a theranostic nanosystem consisting of a tumor vasculature-homing peptide (CGKRK) fused to a pro-apoptotic peptide [D(KLAKLAK)2] coated on iron oxide nanoparticles. This nanosystem showed promising therapeutic efficacy in glioblastoma (GBM) and breast cancer models. However, complete control of the tumors was not achieved, and some tumors became non-responsive to the treatment...
October 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29027306/fenton-reaction-induced-renal-carcinogenesis-in-mutyh-deficient-mice-exhibits-less-chromosomal-aberrations-than-the-rat-model
#11
Guang Hua Li, Shinya Akatsuka, Shan Hwu Chew, Li Jiang, Takahiro Nishiyama, Akihiko Sakamoto, Takashi Takahashi, Mitsuru Futakuchi, Hiromu Suzuki, Kunihiko Sakumi, Yusaku Nakabeppu, Shinya Toyokuni
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26...
October 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29022497/estrogen-induced-disruption-of-intracellular-iron-metabolism-leads-to-oxidative-stress-membrane-damage-and-cell-cycle-arrest-in-mcf-7-cells
#12
Khuloud Bajbouj, Jasmin Shafarin, Maher Y Abdalla, Iman M Ahmad, Mawieh Hamad
It is well established that several forms of cancer associate with significant iron overload. Recent studies have suggested that estrogen (E2) disrupts intracellular iron homeostasis by reducing hepcidin synthesis and maintaining ferroportin integrity. Here, the ability of E2 to alter intracellular iron status and cell growth potential was investigated in MCF-7 cells treated with increasing concentrations of E2. Treated cells were assessed for intracellular iron status, the expression of key proteins involved in iron metabolism, oxidative stress, cell survival, growth, and apoptosis...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28994325/folic-acid-conjugated-peg-coated-gold-iron-oxide-core-shell-nanocomplex-as-a-potential-agent-for-targeted-photothermal-therapy-of-cancer
#13
Habib Ghaznavi, Samira Hosseini-Nami, S Kamran Kamrava, Rasoul Irajirad, Shayan Maleki, Ali Shakeri-Zadeh, Alireza Montazerabadi
This study reports the synthesis and characterization of poly(ethylene glycol) coated gold@iron oxide core-shell nanoparticles conjugated with folic acid (FA-PEG-Au@IONP). Also, targeted therapeutic properties of such a nanocomplex were studied on human nasopharyngeal carcinoma cell line KB and human breast adenocarcinoma cell line MCF-7 in vitro. The synthesized nanocomplex was characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-Vis spectroscopy, vibrating sample magnetometry (VSM), and Fourier transform infrared (FTIR) spectroscopy...
October 10, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28991359/association-between-the-gut-microbiota-and-mineral-metabolism
#14
REVIEW
Katarzyna Skrypnik, Joanna Suliburska
The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and minerals, and the effect of this interaction on the health of the host. The Web of Science database from the years 2013-2017 on this topic was reviewed. Numerous in vitro studies have shown that iron significantly affects the intestinal microbiota. However, Bifidobacteriaceae are capable of binding iron in the large intestine, thereby limiting the formation of free radicals synthesized in the presence of iron, and thus reducing the risk of colorectal cancer...
October 9, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28989585/absolute-and-functional-iron-deficiency-anemia-among-different-tumors-in-cancer-patients-in-south-part-of-iran-2014
#15
Seyed Mehdi Hashemi, Mohammad Ali Mashhadi, Mehdi Mohammadi, Maryam Ebrahimi, Abolghasem Allahyari
Background: Anemia is a common problem in cancer patients. This study aimed to investigate the frequency rate of absolute and functional iron deficiency anemia among different tumors and its distribution in different stages of cancer in solid tumors. Materials and Methods: This study was performed on 597 patients with cancer referred to Ali-Ebne-Abitaleb Hospital in Zahedan. Laboratory tests included serum iron, transferrin saturation, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and complete blood count (CBC)...
July 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28986753/toward-a-new-and-noninvasive-diagnostic-method-of-papillary-thyroid-cancer-by-using-peptide-vectorized-contrast-agents-targeted-to-galectin-1
#16
Deborah Fanfone, Nadège Despretz, Dimitri Stanicki, Jenifer Rubio-Magnieto, Mathieu Fossépré, Mathieu Surin, Sandrine Rorive, Isabelle Salmon, Luce Vander Elst, Sophie Laurent, Robert N Muller, Sven Saussez, Carmen Burtea
The incidence of papillary thyroid cancer has increased these last decades due to a better detection. High prevalence of nodules combined with the low incidence of thyroid cancers constitutes an important diagnostic challenge. We propose to develop an alternative diagnostic method to reduce the number of useless and painful thyroidectomies using a vectorized contrast agent for magnetic resonance imaging. Galectin-1 (gal-1), a protein overexpressed in well-differentiated thyroid cancer, has been targeted with a randomized linear 12-mer peptide library using the phage display technique...
October 6, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28985560/ferroptosis-a-regulated-cell-death-nexus-linking-metabolism-redox-biology-and-disease
#17
REVIEW
Brent R Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I Bush, Marcus Conrad, Scott J Dixon, Simone Fulda, Sergio Gascón, Stavroula K Hatzios, Valerian E Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C Pagnussat, Jason Park, Qitao Ran, Craig S Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M Torti, Suzy V Torti, Shinya Toyokuni, K A Woerpel, Donna D Zhang
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q10...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28983289/dietary-heme-induces-gut-dysbiosis-aggravates-colitis-and-potentiates-the-development-of-adenomas-in-mice
#18
Marco Constante, Gabriela Fragoso, Annie Calvé, Macha Samba-Mondonga, Manuela M Santos
Dietary heme can be used by colonic bacteria equipped with heme-uptake systems as a growth factor and thereby impact on the microbial community structure. The impact of heme on the gut microbiota composition may be particularly pertinent in chronic inflammation such as in inflammatory bowel disease (IBD), where a strong association with gut dysbiosis has been consistently reported. In this study we investigated the influence of dietary heme on the gut microbiota and inferred metagenomic composition, and on chemically induced colitis and colitis-associated adenoma development in mice...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28981278/eight-coordinate-stable-fe-ii-complex-as-a-dual-19-f-and-cest-contrast-agent-for-ratiometric-ph-imaging
#19
Kriti Srivastava, Giuseppe Ferrauto, Victor G Young, Silvio Aime, Valérie C Pierre
Accurate mapping of small changes in pH is essential to the diagnosis of diseases such as cancer. The difficulty in mapping pH accurately in vivo resides in the need for the probe to have a ratiometric response so as to be able to independently determine the concentration of the probe in the body independently from its response to pH. The complex Fe(II)-DOTAm-F12 behaves as an MRI contrast agent with dual (19)F and CEST modality. The magnitude of its CEST response is dependent both on the concentration of the complex and on the pH, with a significant increase in saturation transfer between pH 6...
October 5, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28975372/t-buooh-induces-ferroptosis-in-human-and-murine-cell-lines
#20
Christine Wenz, Dagmar Faust, Berenike Linz, Christian Turmann, Teodora Nikolova, John Bertin, Peter Gough, Peter Wipf, Anna Sophia Schröder, Stefan Krautwald, Cornelia Dietrich
Reactive oxygen species (ROS)-induced apoptosis has been extensively studied. Increasing evidence suggests that ROS, for instance, induced by hydrogen peroxide (H2O2), might also trigger regulated necrotic cell death pathways. Almost nothing is known about the cell death pathways triggered by tertiary-butyl hydroperoxide (t-BuOOH), a widely used inducer of oxidative stress. The lipid peroxidation products induced by t-BuOOH are involved in the pathophysiology of many diseases, such as cancer, cardiovascular diseases, or diabetes...
October 3, 2017: Archives of Toxicology
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