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https://www.readbyqxmd.com/read/27892923/origin-and-function-of-stomata-in-the-moss-physcomitrella-patens
#1
Caspar C Chater, Robert S Caine, Marta Tomek, Simon Wallace, Yasuko Kamisugi, Andrew C Cuming, Daniel Lang, Cora A MacAlister, Stuart Casson, Dominique C Bergmann, Eva L Decker, Wolfgang Frank, Julie E Gray, Andrew Fleming, Ralf Reski, David J Beerling
Stomata are microscopic valves on plant surfaces that originated over 400 million years (Myr) ago and facilitated the greening of Earth's continents by permitting efficient shoot-atmosphere gas exchange and plant hydration(1). However, the core genetic machinery regulating stomatal development in non-vascular land plants is poorly understood(2-4) and their function has remained a matter of debate for a century(5). Here, we show that genes encoding the two basic helix-loop-helix proteins PpSMF1 (SPEECH, MUTE and FAMA-like) and PpSCREAM1 (SCRM1) in the moss Physcomitrella patens are orthologous to transcriptional regulators of stomatal development in the flowering plant Arabidopsis thaliana and essential for stomata formation in moss...
November 28, 2016: Nature Plants
https://www.readbyqxmd.com/read/27806099/plaque-vulnerability-as-assessed-by-radiofrequency-intravascular-ultrasound-in-patients-with-valvular-calcification
#2
Nagendra Boopathy Senguttuvan, Sharath Kumar, Wang-Soo Lee, Sundeep Mishra, Jun Hwan Cho, Jee Eun Kwon, Seong Hyeop Hyeon, Yun Sang Jeong, Hoyoun Won, Seung Yong Shin, Kwang Je Lee, Tae Ho Kim, Chee Jeong Kim, Sang-Wook Kim
BACKGROUND: Cardiac valvular calcification is associated with the overall coronary plaque burden and considered an independent cardiovascular risk and prognostic factor. The purpose of this study was to evaluate the relationship between the presence of valvular calcification and plaque morphology and/or vulnerability. METHODS: Transthoracic echocardiography was used to assess valvular calcification in 280 patients with coronary artery disease who underwent radiofrequency intravascular ultrasound (Virtual Histology IVUS, VH-IVUS)...
2016: PloS One
https://www.readbyqxmd.com/read/27793402/one-year-outcomes-of-transcatheter-aortic%C3%A2-valve-implantation-using-the-direct%C3%A2-aortic%C3%A2-approach
#3
Giuseppe Bruschi, Marian Branny, Molly Schiltgen, Federica Ettori, Bertrand Marcheix, Hafid Amrane, Hasan Bushnaq, M Erwin S H Tan, Uday Trivedi, Piotr Branny, Silvio Klugmann, Giuseppe Coletti, Nicolas Dumonteil, Fabiano Porta, Anna Nordell, Neil Moat
BACKGROUND: The direct aortic (DA) approach allows for transcatheter aortic valve implantation (TAVI) in patients with difficult peripheral vascular anatomy. The CoreValve ADVANCE Direct Aortic (ADVANCE DA) study was performed to assess the outcomes of DA TAVI with the CoreValve System (Medtronic, Minneapolis, MN) in routine practice. METHODS: Patients were selected for the DA approach by local cardiac surgical teams, and TAVI was performed with patients under general anesthesia...
October 25, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27782584/a-kind-of-fast-shutter-for-z-pinch-diagnosis-device
#4
Liangping Wang, Xinjun Zhang, Tieping Sun, Wentin Mao
A kind of fast shutter for protecting the diagnosis devices in Z pinch experiments is introduced in this paper. The shutter is composed of a pulling rod, a magnetic core, and a solenoid. Different from the traditional coils which were used at the voltage of 220 V, the solenoid we used must endure the high voltage of 5-10 kV and the deformation which maybe caused by the 5-10 T intense magnetic field. A creative configuration for the solenoid is developed including the winding guide, insulating sleeve, and stainless-steel sleeve...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27776799/relation-between-clinical-best-practices-and-6-month-outcomes-after-transcatheter-aortic-valve-implantation-with-corevalve-from-the-advance-ii-study
#5
Jan-Malte Sinning, Anna Sonia Petronio, Nicolas Van Mieghem, Giulio Zucchelli, Georg Nickenig, Raffi Bekeredjian, Johan Bosmans, Francesco Bedogni, Marian Branny, Karl Stangl, Jan Kovac, Anna Nordell, Molly Schiltgen, Nicolo Piazza, Peter de Jaegere
Best practices for transcatheter aortic valve implantation with CoreValve include patient screening and valve size selection using multislice computed tomography, adherence to manufacturer recommendations for oversizing, control of implant depth to 6 mm or less, and management of conduction disturbances according to international guidelines. The ADVANCE II study implemented these strategies and demonstrated their relation to clinical outcomes. From October 2011 to April 2013, 200 patients with severe aortic stenosis were enrolled, and 194 were implanted...
September 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27761301/occult-primary-neuroendocrine-tumor-metastasis-to-the-breast-detected-on-screening-mammogram
#6
Fabiana Policeni, Brittany Pakalniskis, Limin Yang
Metastatic tumors are rare in the breast. Well-differentiated neuroendocrine tumors (WDNETs) are slow-growing neoplasms that arise from neuroendocrine cells, particularly in the gastrointestinal tract and bronchial tree. Metastatic WDNET to the breast is a rare entity. We present a case report of ileal WDNET metastatic to the breast which was initially identified as a small mass in the patient's left breast on screening mammography. Targeted ultrasound identified a suspicious mass, and ultrasound-guided percutaneous core biopsy was performed...
2016: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/27577965/embolic-protection-in-patients-undergoing-transaortic-transcatheter-aortic-valve-replacement-initial-experience-with-the-triguard-hdh-embolic-deflection-device
#7
Francisco Campelo-Parada, Ander Regueiro, Eric Dumont, Robert DeLarochellière, Jean-Michel Paradis, Siamak Mohammadi, Daniel Doyle, Josep Rodés-Cabau
BACKGROUND: Stroke remains one of the most worrisome complications following transcatheter aortic valve replacement (TAVR). This pilot study evaluates the safety, feasibility, and exploratory efficacy of the TriGuard HDH embolic deflection device (Keystone Heart Ltd., Caesarea, Israel) in patients undergoing transaortic TAVR. METHODS: A total of 10 patients (median age: 81 years, STS score: 9.6 ± 5.6%) undergoing transaortic TAVR were included. All 30-day events were recorded and defined according to Valve Academic Research Consortium-2 criteria...
October 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27400898/one-year-clinical-outcomes-with-sapien-3-transcatheter-aortic-valve-replacement-in-high-risk-and-inoperable-patients-with-severe-aortic-stenosis
#8
Howard C Herrmann, Vinod H Thourani, Susheel K Kodali, Raj R Makkar, Wilson Y Szeto, Saif Anwaruddin, Nimesh Desai, Scott Lim, S Chris Malaisrie, Dean J Kereiakes, Steven Ramee, Kevin L Greason, Samir Kapadia, Vasilis Babaliaros, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, Jonathon Leipsic, Brian K Whisenant, John G Webb, Michael J Mack, Martin B Leon
BACKGROUND: In the initial PARTNER trial (Placement of Aortic Transcatheter Valves) of transcatheter aortic valve replacement for high-risk (HR) and inoperable patients, mortality at 1 year was 24% in HR and 31% in inoperable patients. A recent report of the 30-day outcomes with the low-profile SAPIEN 3 transcatheter aortic valve replacement system demonstrated very low rates of adverse events, but little is known about the longer-term outcomes with this device. METHODS: Between October 2013 and September 2014, 583 HR (65%) or inoperable (35%) patients were treated via the transfemoral (84%) or transapical/transaortic (16%) access route at 29 US sites...
July 12, 2016: Circulation
https://www.readbyqxmd.com/read/27382177/grasses-use-an-alternatively-wired-bhlh-transcription-factor-network-to-establish-stomatal-identity
#9
Michael T Raissig, Emily Abrash, Akhila Bettadapur, John P Vogel, Dominique C Bergmann
Stomata, epidermal valves facilitating plant-atmosphere gas exchange, represent a powerful model for understanding cell fate and pattern in plants. Core basic helix-loop-helix (bHLH) transcription factors regulating stomatal development were identified in Arabidopsis, but this dicot's developmental pattern and stomatal morphology represent only one of many possibilities in nature. Here, using unbiased forward genetic screens, followed by analysis of reporters and engineered mutants, we show that stomatal initiation in the grass Brachypodium distachyon uses orthologs of stomatal regulators known from Arabidopsis but that the function and behavior of individual genes, the relationships among genes, and the regulation of their protein products have diverged...
July 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27377369/dual-shell-fluorescent-nanoparticles-for-self-monitoring-of-ph-responsive-molecule-releasing-in-a-visualized-way
#10
Lingang Yang, Chuanfeng Cui, Lingzhi Wang, Juying Lei, Jinlong Zhang
The rational design and controlled synthesis of a smart device with flexibly tailored response ability is all along desirable for bioapplication but long remains a considerable challenge. Here, a pH-stimulated valve system with a visualized "on-off" mode is constructed through a dual-shell fluorescence resonance energy transfer (FRET) strategy. The dual shells refer to carbon dots and fluorescent molecules embedded polymethacrylic acid (F-PMAA) layers successively coating around a SiO2 core (ca. 120 nm), which play the roles as energy donor and acceptor, respectively...
July 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27351480/health-care-multidisciplinary-teams-the-sociotechnical-approach-for-an-integrated-system-wide-perspective
#11
Marta Marsilio, Aleksandra Torbica, Stefano Villa
BACKGROUND: The current literature on the enabling conditions of multidisciplinary teams focuses on the singular dimensions of the organizations (i.e., human resources, clinical pathways, objects) without shedding light on to the way in which these organizational factors interact and mutually influence one another. PURPOSE: Drawing on a system perspective of organizations, the authors analyze the organizational patterns that promote and support multidisciplinary teams and how they interrelate and interact to enforce the organization work system...
June 27, 2016: Health Care Management Review
https://www.readbyqxmd.com/read/27339489/treatment-of-chronic-functional-mitral%C3%A2-valve-regurgitation-with-a-percutaneous-annuloplasty-system
#12
Georg Nickenig, Robert Schueler, Antonio Dager, Pedro Martinez Clark, Alexandre Abizaid, Tomasz Siminiak, Pawel Buszman, Marcin Demkow, Adrian Ebner, Federico M Asch, Christoph Hammerstingl
BACKGROUND: Current surgical and medical treatment options for functional mitral regurgitation (FMR) are limited and additional interventional approaches are required. OBJECTIVES: This study sought to report the safety and performance data from the feasibility study with a novel direct annuloplasty system. METHODS: Seventy-one patients with moderate to severe FMR (mean 67.7 ± 11.3 years of age, left ventricular [LV] ejection fraction 34.0 ± 8...
June 28, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27315372/characterization-of-biomechanical-properties-of-aged-human-and-ovine-mitral-valve-chordae-tendineae
#13
Keping Zuo, Thuy Pham, Kewei Li, Caitlin Martin, Zhaoming He, Wei Sun
The mitral valve (MV) is a highly complex cardiac valve consisting of an annulus, anterior and posterior leaflets, chordae tendineae (chords) and two papillary muscles. The chordae tendineae mechanics play a pivotal role in proper MV function: the chords help maintain proper leaflet coaptation and rupture of the chordae tendineae due to disease or aging can lead to mitral valve insufficiency. Therefore, the aim of this study was to characterize the mechanical properties of aged human and ovine mitral chordae tendineae...
September 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27313280/self-expanding-transcatheter-aortic-valve-replacement-versus-surgical-valve-replacement-in-patients-at-high-risk-for-surgery-a-study-of-echocardiographic-change-and-risk-prediction
#14
Stephen H Little, Jae K Oh, Linda Gillam, Partho P Sengupta, David A Orsinelli, João L Cavalcante, James D Chang, David H Adams, George L Zorn, Amy W Pollak, Sahar S Abdelmoneim, Michael J Reardon, Hongyan Qiao, Jeffrey J Popma
BACKGROUND: The CoreValve US High-Risk Clinical Study compared clinical outcomes and serial echocardiographic findings in patients with severe aortic valve stenosis after transcatheter aortic valve replacement (TAVR) with a self-expanding bioprosthesis or surgical aortic valve replacement (SAVR). METHODS AND RESULTS: Eligible patients were randomly assigned 1:1 to TAVR with a self-expanding bioprosthesis or SAVR (N=747). Echocardiograms were obtained at baseline, discharge, 30 days, 6 months, and 1 year after the procedure and were analyzed at a central core laboratory...
June 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27301396/transcatheter-replacement-of-failed-bioprosthetic-valves-large-multicenter-assessment-of-the-effect-of-implantation-depth-on-hemodynamics-after-aortic-valve-in-valve
#15
Matheus Simonato, John Webb, Ran Kornowski, Alec Vahanian, Christian Frerker, Henrik Nissen, Sabine Bleiziffer, Alison Duncan, Josep Rodés-Cabau, Guilherme F Attizzani, Eric Horlick, Azeem Latib, Raffi Bekeredjian, Marco Barbanti, Thierry Lefevre, Alfredo Cerillo, José María Hernández, Giuseppe Bruschi, Konstantinos Spargias, Alessandro Iadanza, Stephen Brecker, José Honório Palma, Ariel Finkelstein, Mohamed Abdel-Wahab, Pedro Lemos, Anna Sonia Petronio, Didier Champagnac, Jan-Malte Sinning, Stefano Salizzoni, Massimo Napodano, Claudia Fiorina, Antonio Marzocchi, Martin Leon, Danny Dvir
BACKGROUND: Transcatheter valve implantation inside failed bioprosthetic surgical valves (valve-in-valve [ViV]) may offer an advantage over reoperation. Supra-annular transcatheter valve position may be advantageous in achieving better hemodynamics after ViV. Our objective was to define targets for implantation that would improve hemodynamics after ViV. METHODS AND RESULTS: Cases from the Valve-in-Valve International Data (VIVID) registry were analyzed using centralized core laboratory assessment blinded to clinical events...
June 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27296201/early-recovery-of-left-ventricular-systolic-function-after-corevalve-transcatheter-aortic-valve-replacement
#16
Harold L Dauerman, Michael J Reardon, Jeffrey J Popma, Stephen H Little, João L Cavalcante, David H Adams, Neil S Kleiman, Jae K Oh
BACKGROUND: Approximately one third of patients with symptomatic aortic stenosis have reduced left ventricular ejection fraction (LVEF) before transcatheter aortic valve replacement. The incidence, predictors, and significance of early LVEF recovery after CoreValve transcatheter aortic valve replacement have not been described. METHODS AND RESULTS: We studied 156 patients from the CoreValve Extreme and High-Risk trials with LVEF ≤40% at baseline who had 30-day LVEF data...
June 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27290682/thirty-day-outcomes-in-patients-at-intermediate-risk-for-surgery-from-the-sapien-3-european-approval-trial
#17
Alec Vahanian, Marina Urena, Thomas Walther, Hendrik Treede, Olaf Wendler, Thierry Lefèvre, Mark S Spence, Simon Redwood, Philipp Kahlert, Josep Rodes-Cabau, Jonathon Leipsic, John Webb
AIMS: This study sought to investigate outcomes of transcatheter aortic valve implantation (TAVI) with the SAPIEN 3 transcatheter heart valve (THV) in patients at intermediate risk for surgery. The 30-day results of the transfemoral cohort are reported. METHODS AND RESULTS: The SAPIEN 3 European approval trial intermediate-risk cohort included a total of 101 patients with severe, symptomatic aortic stenosis, at intermediate risk for surgery suitable for TAVI via the transfemoral route (TF)...
June 12, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27282895/aortic-dissection-in-patients-with-genetically-mediated-aneurysms-incidence-and-predictors-in-the-gentac-registry
#18
Jonathan W Weinsaft, Richard B Devereux, Liliana R Preiss, Attila Feher, Mary J Roman, Craig T Basson, Alexi Geevarghese, William Ravekes, Harry C Dietz, Kathryn Holmes, Jennifer Habashi, Reed E Pyeritz, Joseph Bavaria, Karianna Milewski, Scott A LeMaire, Shaine Morris, Dianna M Milewicz, Siddharth Prakash, Cheryl Maslen, Howard K Song, G Michael Silberbach, Ralph V Shohet, Nazli McDonnell, Tabitha Hendershot, Kim A Eagle, Federico M Asch
BACKGROUND: Aortic dissection (AoD) is a serious complication of thoracic aortic aneurysm (TAA). Relative risk for AoD in relation to TAA etiology, incidence, and pattern after prophylactic TAA surgery are poorly understood. OBJECTIVES: This study sought to determine the incidence, pattern, and relative risk for AoD among patients with genetically associated TAA. METHODS: The population included adult GenTAC participants without AoD at baseline...
June 14, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27242807/tuning-of-redox-regulatory-mechanisms-reactive-oxygen-species-and-redox-homeostasis-under-salinity-stress
#19
REVIEW
M Sazzad Hossain, Karl-Josef Dietz
Soil salinity is a crucial environmental constraint which limits biomass production at many sites on a global scale. Saline growth conditions cause osmotic and ionic imbalances, oxidative stress and perturb metabolism, e.g., the photosynthetic electron flow. The plant ability to tolerate salinity is determined by multiple biochemical and physiological mechanisms protecting cell functions, in particular by regulating proper water relations and maintaining ion homeostasis. Redox homeostasis is a fundamental cell property...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27237075/traf3ip2-mediates-atherosclerotic-plaque-development-and-vulnerability-in-apoe-mice
#20
Siva Sankara Vara Prasad Sakamuri, Yusuke Higashi, Sergiy Sukhanov, Jalahalli M Siddesha, Patrice Delafontaine, Ulrich Siebenlist, Bysani Chandrasekar
BACKGROUND AND AIMS: Atherosclerosis is a major cause of heart attack and stroke. Inflammation plays a critical role in the development of atherosclerosis. Since the cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2 mediates atherosclerotic plaque development. METHODS: TRAF3IP2/ApoE double knockout (DKO) mice were generated by crossing TRAF3IP2(-/-) and ApoE(-/-) mice...
September 2016: Atherosclerosis
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