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Fabiana Policeni, Brittany Pakalniskis, Limin Yang
Metastatic tumors are rare in the breast. Well-differentiated neuroendocrine tumors (WDNETs) are slow-growing neoplasms that arise from neuroendocrine cells, particularly in the gastrointestinal tract and bronchial tree. Metastatic WDNET to the breast is a rare entity. We present a case report of ileal WDNET metastatic to the breast which was initially identified as a small mass in the patient's left breast on screening mammography. Targeted ultrasound identified a suspicious mass, and ultrasound-guided percutaneous core biopsy was performed...
2016: Journal of Clinical Imaging Science
Francisco Campelo-Parada, Ander Regueiro, Eric Dumont, Robert DeLarochellière, Jean-Michel Paradis, Siamak Mohammadi, Daniel Doyle, Josep Rodés-Cabau
BACKGROUND: Stroke remains one of the most worrisome complications following transcatheter aortic valve replacement (TAVR). This pilot study evaluates the safety, feasibility, and exploratory efficacy of the TriGuard HDH embolic deflection device (Keystone Heart Ltd., Caesarea, Israel) in patients undergoing transaortic TAVR. METHODS: A total of 10 patients (median age: 81 years, STS score: 9.6 ± 5.6%) undergoing transaortic TAVR were included. All 30-day events were recorded and defined according to Valve Academic Research Consortium-2 criteria...
October 2016: Journal of Cardiac Surgery
Howard C Herrmann, Vinod H Thourani, Susheel K Kodali, Raj R Makkar, Wilson Y Szeto, Saif Anwaruddin, Nimesh Desai, Scott Lim, S Chris Malaisrie, Dean J Kereiakes, Steven Ramee, Kevin L Greason, Samir Kapadia, Vasilis Babaliaros, Rebecca T Hahn, Philippe Pibarot, Neil J Weissman, Jonathon Leipsic, Brian K Whisenant, John G Webb, Michael J Mack, Martin B Leon
BACKGROUND: In the initial PARTNER trial (Placement of Aortic Transcatheter Valves) of transcatheter aortic valve replacement for high-risk (HR) and inoperable patients, mortality at 1 year was 24% in HR and 31% in inoperable patients. A recent report of the 30-day outcomes with the low-profile SAPIEN 3 transcatheter aortic valve replacement system demonstrated very low rates of adverse events, but little is known about the longer-term outcomes with this device. METHODS: Between October 2013 and September 2014, 583 HR (65%) or inoperable (35%) patients were treated via the transfemoral (84%) or transapical/transaortic (16%) access route at 29 US sites...
July 12, 2016: Circulation
Michael T Raissig, Emily Abrash, Akhila Bettadapur, John P Vogel, Dominique C Bergmann
Stomata, epidermal valves facilitating plant-atmosphere gas exchange, represent a powerful model for understanding cell fate and pattern in plants. Core basic helix-loop-helix (bHLH) transcription factors regulating stomatal development were identified in Arabidopsis, but this dicot's developmental pattern and stomatal morphology represent only one of many possibilities in nature. Here, using unbiased forward genetic screens, followed by analysis of reporters and engineered mutants, we show that stomatal initiation in the grass Brachypodium distachyon uses orthologs of stomatal regulators known from Arabidopsis but that the function and behavior of individual genes, the relationships among genes, and the regulation of their protein products have diverged...
July 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
Lingang Yang, Chuanfeng Cui, Lingzhi Wang, Juying Lei, Jinlong Zhang
The rational design and controlled synthesis of a smart device with flexibly tailored response ability is all along desirable for bioapplication but long remains a considerable challenge. Here, a pH-stimulated valve system with a visualized "on-off" mode is constructed through a dual-shell fluorescence resonance energy transfer (FRET) strategy. The dual shells refer to carbon dots and fluorescent molecules embedded polymethacrylic acid (F-PMAA) layers successively coating around a SiO2 core (ca. 120 nm), which play the roles as energy donor and acceptor, respectively...
July 27, 2016: ACS Applied Materials & Interfaces
Marta Marsilio, Aleksandra Torbica, Stefano Villa
BACKGROUND: The current literature on the enabling conditions of multidisciplinary teams focuses on the singular dimensions of the organizations (i.e., human resources, clinical pathways, objects) without shedding light on to the way in which these organizational factors interact and mutually influence one another. PURPOSE: Drawing on a system perspective of organizations, the authors analyze the organizational patterns that promote and support multidisciplinary teams and how they interrelate and interact to enforce the organization work system...
June 27, 2016: Health Care Management Review
Georg Nickenig, Robert Schueler, Antonio Dager, Pedro Martinez Clark, Alexandre Abizaid, Tomasz Siminiak, Pawel Buszman, Marcin Demkow, Adrian Ebner, Federico M Asch, Christoph Hammerstingl
BACKGROUND: Current surgical and medical treatment options for functional mitral regurgitation (FMR) are limited and additional interventional approaches are required. OBJECTIVES: This study sought to report the safety and performance data from the feasibility study with a novel direct annuloplasty system. METHODS: Seventy-one patients with moderate to severe FMR (mean 67.7 ± 11.3 years of age, left ventricular [LV] ejection fraction 34.0 ± 8...
June 28, 2016: Journal of the American College of Cardiology
Keping Zuo, Thuy Pham, Kewei Li, Caitlin Martin, Zhaoming He, Wei Sun
The mitral valve (MV) is a highly complex cardiac valve consisting of an annulus, anterior and posterior leaflets, chordae tendineae (chords) and two papillary muscles. The chordae tendineae mechanics play a pivotal role in proper MV function: the chords help maintain proper leaflet coaptation and rupture of the chordae tendineae due to disease or aging can lead to mitral valve insufficiency. Therefore, the aim of this study was to characterize the mechanical properties of aged human and ovine mitral chordae tendineae...
September 2016: Journal of the Mechanical Behavior of Biomedical Materials
Stephen H Little, Jae K Oh, Linda Gillam, Partho P Sengupta, David A Orsinelli, João L Cavalcante, James D Chang, David H Adams, George L Zorn, Amy W Pollak, Sahar S Abdelmoneim, Michael J Reardon, Hongyan Qiao, Jeffrey J Popma
BACKGROUND: The CoreValve US High-Risk Clinical Study compared clinical outcomes and serial echocardiographic findings in patients with severe aortic valve stenosis after transcatheter aortic valve replacement (TAVR) with a self-expanding bioprosthesis or surgical aortic valve replacement (SAVR). METHODS AND RESULTS: Eligible patients were randomly assigned 1:1 to TAVR with a self-expanding bioprosthesis or SAVR (N=747). Echocardiograms were obtained at baseline, discharge, 30 days, 6 months, and 1 year after the procedure and were analyzed at a central core laboratory...
June 2016: Circulation. Cardiovascular Interventions
Matheus Simonato, John Webb, Ran Kornowski, Alec Vahanian, Christian Frerker, Henrik Nissen, Sabine Bleiziffer, Alison Duncan, Josep Rodés-Cabau, Guilherme F Attizzani, Eric Horlick, Azeem Latib, Raffi Bekeredjian, Marco Barbanti, Thierry Lefevre, Alfredo Cerillo, José María Hernández, Giuseppe Bruschi, Konstantinos Spargias, Alessandro Iadanza, Stephen Brecker, José Honório Palma, Ariel Finkelstein, Mohamed Abdel-Wahab, Pedro Lemos, Anna Sonia Petronio, Didier Champagnac, Jan-Malte Sinning, Stefano Salizzoni, Massimo Napodano, Claudia Fiorina, Antonio Marzocchi, Martin Leon, Danny Dvir
BACKGROUND: Transcatheter valve implantation inside failed bioprosthetic surgical valves (valve-in-valve [ViV]) may offer an advantage over reoperation. Supra-annular transcatheter valve position may be advantageous in achieving better hemodynamics after ViV. Our objective was to define targets for implantation that would improve hemodynamics after ViV. METHODS AND RESULTS: Cases from the Valve-in-Valve International Data (VIVID) registry were analyzed using centralized core laboratory assessment blinded to clinical events...
June 2016: Circulation. Cardiovascular Interventions
Harold L Dauerman, Michael J Reardon, Jeffrey J Popma, Stephen H Little, João L Cavalcante, David H Adams, Neil S Kleiman, Jae K Oh
BACKGROUND: Approximately one third of patients with symptomatic aortic stenosis have reduced left ventricular ejection fraction (LVEF) before transcatheter aortic valve replacement. The incidence, predictors, and significance of early LVEF recovery after CoreValve transcatheter aortic valve replacement have not been described. METHODS AND RESULTS: We studied 156 patients from the CoreValve Extreme and High-Risk trials with LVEF ≤40% at baseline who had 30-day LVEF data...
June 2016: Circulation. Cardiovascular Interventions
Alec Vahanian, Marina Urena, Thomas Walther, Hendrik Treede, Olaf Wendler, Thierry Lefèvre, Mark S Spence, Simon Redwood, Philipp Kahlert, Josep Rodes-Cabau, Jonathon Leipsic, John Webb
AIMS: This study sought to investigate outcomes of transcatheter aortic valve implantation (TAVI) with the SAPIEN 3 transcatheter heart valve (THV) in patients at intermediate risk for surgery. The 30-day results of the transfemoral cohort are reported. METHODS AND RESULTS: The SAPIEN 3 European approval trial intermediate-risk cohort included a total of 101 patients with severe, symptomatic aortic stenosis, at intermediate risk for surgery suitable for TAVI via the transfemoral route (TF)...
June 12, 2016: EuroIntervention
Jonathan W Weinsaft, Richard B Devereux, Liliana R Preiss, Attila Feher, Mary J Roman, Craig T Basson, Alexi Geevarghese, William Ravekes, Harry C Dietz, Kathryn Holmes, Jennifer Habashi, Reed E Pyeritz, Joseph Bavaria, Karianna Milewski, Scott A LeMaire, Shaine Morris, Dianna M Milewicz, Siddharth Prakash, Cheryl Maslen, Howard K Song, G Michael Silberbach, Ralph V Shohet, Nazli McDonnell, Tabitha Hendershot, Kim A Eagle, Federico M Asch
BACKGROUND: Aortic dissection (AoD) is a serious complication of thoracic aortic aneurysm (TAA). Relative risk for AoD in relation to TAA etiology, incidence, and pattern after prophylactic TAA surgery are poorly understood. OBJECTIVES: This study sought to determine the incidence, pattern, and relative risk for AoD among patients with genetically associated TAA. METHODS: The population included adult GenTAC participants without AoD at baseline...
June 14, 2016: Journal of the American College of Cardiology
M Sazzad Hossain, Karl-Josef Dietz
Soil salinity is a crucial environmental constraint which limits biomass production at many sites on a global scale. Saline growth conditions cause osmotic and ionic imbalances, oxidative stress and perturb metabolism, e.g., the photosynthetic electron flow. The plant ability to tolerate salinity is determined by multiple biochemical and physiological mechanisms protecting cell functions, in particular by regulating proper water relations and maintaining ion homeostasis. Redox homeostasis is a fundamental cell property...
2016: Frontiers in Plant Science
Siva Sankara Vara Prasad Sakamuri, Yusuke Higashi, Sergiy Sukhanov, Jalahalli M Siddesha, Patrice Delafontaine, Ulrich Siebenlist, Bysani Chandrasekar
BACKGROUND AND AIMS: Atherosclerosis is a major cause of heart attack and stroke. Inflammation plays a critical role in the development of atherosclerosis. Since the cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2 mediates atherosclerotic plaque development. METHODS: TRAF3IP2/ApoE double knockout (DKO) mice were generated by crossing TRAF3IP2(-/-) and ApoE(-/-) mice...
September 2016: Atherosclerosis
Mitrofanis Pavlidis
Purpose. To evaluate comparative aspiration flow performance and also vitrectomy operating time efficiency using a double-cutting open port vitreous cutting system incorporated in a two-dimensional cutting (TDC, DORC International) vitrectome design versus standard vitreous cutter. Methods. In vitro investigations compared aspiration flow rates in artificial vitreous humor at varying cutter speeds and vacuum levels using a TDC vitrectome and a standard vitrectome across different aspiration pump systems. A prospective single-centre clinical study evaluated duration of core vitrectomy in 80 patients with macular pucker undergoing 25-gauge or 27-gauge vitrectomy using either a TDC vitrectome at 16,000 cuts per minute (cpm) or standard single-cut vitrectome, combined with a Valve Timing intelligence (VTi) pump system (EVA, DORC International)...
2016: Journal of Ophthalmology
Elisa Vereda Alonso, Ma Del Mar Guerrero, Pilar Colorado Cueto, José Barreno Benítez, José Manuel Cano Pavón, Amparo García de Torres
A new chelating sorbent which employs magnetic nanoparticles (MNPs) functionalized with 1,5-bis(di-2-pyridil)methylene thiocarbohydrazide (DPTH-MNPs) was synthetized and characterized. The aim of the synthesis of this material was to develop fast and simple methods for analysis of trace amounts of metal ions present in biological and environmental samples combining on-line magnetic solid phase microextraction (MSPME) with atomic spectrometry. The MNPs' magnetic core allows overcoming the backpressure problems that usually happen in SPME methods with NPs thanks to the possibility of immobilizing the MNPs by applying an external magnetic field...
June 1, 2016: Talanta
Daisuke Ito, Masanori Teruya, Shojiro Hata, Kaoru Kobayashi, Michio Kaminishi
BACKGROUND: There were only few case reports in which CTC was performed in patients with colostomy. CASE PRESENTATION: A 68-year-old man was admitted with right abdominal pain and bloody stool that had been present for 2 weeks prior to admission. His medical history included abdominoperineal rectal resection with permanent sigmoid stoma (Miles operation). Colonoscopy showed a sub-occlusive tumor in the transverse colon but provided no information about the proximal colon...
2016: World Journal of Surgical Oncology
Trent Reed, Matthew Pirotte, Mary McHugh, Laura Oh, Shannon Lovett, Amy E Hoyt, Donna Quinones, William Adams, Gregory Gruener, William C McGaghie
INTRODUCTION: Simulation-based mastery learning (SBML) improves procedural skills among medical trainees. We employed an SBML method that includes an asynchronous knowledge acquisition portion and a hands-on skill acquisition portion with simulation to assess senior medical student performance and retention of the following 6 core clinical skills: (a) ultrasound-guided peripheral intravenous placement, (b) basic skin laceration repair, (c) chest compressions, (d) bag-valve mask ventilation, (e) defibrillator management, and (f) code leadership...
June 2016: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
Milan A Nedeljković, Branko Beleslin, Milorad Tesić, Vladan Vukcević, Goran Stanković, Sinisa Stojković, Dejan Orlić, Ilija Bilbija, Milos Matković, Tijana Simić, Nemanja Menković, Igor Mrdović, Gian Paolo Ussia, Zoran Perisić, Momcilo Babić
BACKGROUND/AIM: Aortic stenosis (AS) is the most common valvular heart disease in elderly people, with rather poor prognosis in symptomatic patients. Surgical valve replacement is the therapy of choice, but a significant number of patients cannot undergo surgical procedure. We presented initial experience of transcatheter aortic valve implantation (TAVI) performed in Catheterization Laboratory of the Clinic for Cardiology, Clinical Center of Serbia. METHODS: The procedures were performed in 5 patients (mean age 76 ± 6 years, 2 males, 3 female) with severe and symptomatic AS with contraindication to surgery or high surgical risk...
February 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
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