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https://www.readbyqxmd.com/read/28651336/safety-and-efficacy-of-a-repositionable-and-fully-retrievable-aortic-valve-used-in-routine-clinical-practice-the-respond-study
#1
Volkmar Falk, Jochen Wöhrle, David Hildick-Smith, Sabine Bleiziffer, Daniel J Blackman, Mohamed Abdel-Wahab, Ulrich Gerckens, Axel Linke, Hüseyin Ince, Peter Wenaweser, Dominic J Allocco, Keith D Dawkins, Nicolas M Van Mieghem
Aims: RESPOND is a prospective, open-label, single-arm study evaluating the outcomes following transcatheter aortic valve implantation (TAVI) with the repositionable and fully retrievable Lotus Valve used in routine clinical practice for the treatment of patients with aortic valve stenosis. Methods and results: RESPOND enrolled 1014 patients at sites across Europe, New Zealand, and Latin America; 996 patients received a Lotus Valve (mean age: 80.8 years; 50.8% female; Society of Thoracic Surgeons score: 6...
June 22, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28634535/effectiveness-and-safety-of-daptomycin-in-patients-with-infective-endocarditis-undergoing-heart-valve-replacement-a-subgroup-analysis-from-real-world-data
#2
Achyut Guleri, Riccardo Utili, Pascal Dohmen, Kamal Hamed
BACKGROUND: European Cubicin(®) Outcomes Registry and Experience (EU-CORE) was a retrospective, non-interventional, multicenter registry that collected real-world clinical outcomes following daptomycin use for the treatment of Gram-positive infections. EU-CORE data from patients with infective endocarditis (IE) who underwent heart valve replacement were analysed. METHODS: Clinical outcomes were assessed as success (cured or improved), failure, or non-evaluable...
March 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28605428/the-commence-trial-2-year-outcomes-with-an-aortic-bioprosthesis-with-resilia-tissue%C3%A2
#3
John D Puskas, Joseph E Bavaria, Lars G Svensson, Eugene H Blackstone, Bartley Griffith, James S Gammie, David A Heimansohn, Jerzy Sadowski, Krzysztof Bartus, Douglas R Johnston, Jacek Rozanski, Todd Rosengart, Leonard N Girardi, Charles T Klodell, Mubashir A Mumtaz, Hiroo Takayama, Michael Halkos, Vaughn Starnes, Percy Boateng, Tomasz A Timek, William Ryan, Shuab Omer, Craig R Smith
OBJECTIVES: The COMMENCE trial was conducted to evaluate the safety and effectiveness of a novel bioprosthetic tissue for surgical aortic valve replacement (AVR). METHODS: Patients underwent clinically indicated surgical AVR with the Carpentier-Edwards PERIMOUNT™ Magna Ease™ aortic valve with RESILIA™ tissue (Model 11000A) in a prospective, multinational, multicentre ( n  = 27), single-arm, FDA Investigational Device Exemption trial. Events were adjudicated by an independent Clinical Events Committee; echocardiograms were analysed by an independent Core Laboratory...
June 10, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28595747/transcathether-aortic-valve-implantation-with-the-new-repositionable-self-expandable-evolut-r-versus-corevalve-system-a-case-matched-comparison
#4
Cristina Giannini, Marco De Carlo, Corrado Tamburino, Federica Ettori, Azeem M Latib, Francesco Bedogni, Giuseppe Bruschi, Patrizia Presbitero, Arnaldo Poli, Franco Fabbiocchi, Roberto Violini, Carlo Trani, Pietro Giudice, Marco Barbanti, Marianna Adamo, Paola Colombo, Susanna Benincasa, Mauro Agnifili, A Sonia Petronio
BACKGROUND: Despite promising results following transcatheter aortic valve implantation (TAVI), several relevant challenges still remain. To overcome these issues, new generation devices have been developed. The purpose of the present study was to determine whether TAVI with the new self-expanding repositionable Evolut R offers potential benefits compared to the preceding CoreValve, using propensity matching. METHODS: Between June 2007 and November 2015, 2148 consecutive patients undergoing TAVI either CoreValve (n=1846) or Evolut R (n=302) were prospectively included in the Italian TAVI ClinicalService® project...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28557850/compensatory-muscle-activation-during-unstable-overhead-squat-using-a-water-filled-training-tube
#5
Stephen C Glass, Robert W Albert
The purpose of this study was to assess compensatory muscle activation of core and support muscle during an overhead squat using a water-filled training tube. Eleven experienced weight lifting (age= 20.10 ± 0.99, mass 89.17 ± 6.88kg) men completed three, 30s trials of an overhead squat using an 11.4 kg tube that was partially filled with water. A central valve allowed three conditions of water movement: 50% open, 100% open, and a stable(S), closed valve condition. Subjects completed 8-10 repetitions within each condition...
May 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28555592/repositionable-percutaneous-aortic-valve-implantation-with-the-lotus-valve-30-day-and-1-year-outcomes-in-250-high-risk-surgical-patients
#6
Ian T Meredith, Nicolas Dumonteil, Daniel J Blackman, Didier Tchétché, Darren L Walters, David Hildick-Smith, Ganesh Manoharan, Jan Harnek, Stephen G Worthley, Gilles Rioufol, Thierry Lefèvre, Thomas Modine, Nicolas M Van Mieghem, Ted Feldman, Dominic J Allocco, Keith D Dawkins
AIMS: The REPRISE IIE trial evaluated outcomes following transcatheter aortic valve implantation of the fully repositionable and retrievable Lotus Valve with a unique seal designed to minimize paravalvular leak (PVL). METHODS AND RESULTS: This prospective, multicentre study enrolled 250 patients with severe aortic stenosis considered high-risk for surgery by a multidisciplinary Heart Team. An independent Clinical Events Committee adjudicated events per Valve Academic Research Consortium criteria...
May 30, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28535962/predictors-of-paravalvular-regurgitation-after-implantation-of-the-fully-repositionable-and-retrievable-lotus-transcatheter-aortic-valve-from-the-reprise-ii-trial-extended-cohort
#7
Daniel J Blackman, Ian T Meredith, Nicolas Dumonteil, Didier Tchétché, David Hildick-Smith, Mark S Spence, Darren L Walters, Jan Harnek, Stephen G Worthley, Gilles Rioufol, Thierry Lefèvre, Vicki M Houle, Dominic J Allocco, Keith D Dawkins
Paravalvular leak (PVL) after transcatheter aortic valve replacement is associated with worse long-term outcomes. The Lotus Valve incorporates an innovative Adaptive Seal designed to minimize PVL. This analysis evaluated the incidence and predictors of PVL after implantation of the Lotus transcatheter aortic valve. The REPRISE II (REpositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of Lotus Valve System - Evaluation of Safety and Performance) Study With Extended Cohort enrolled 250 high-surgical risk patients with severe symptomatic aortic stenosis...
July 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28521921/1-year-results-in-patients-undergoing-transcatheter-aortic-valve-replacement-with-failed-surgical-bioprostheses
#8
G Michael Deeb, Stanley J Chetcuti, Michael J Reardon, Himanshu J Patel, P Michael Grossman, Theodore Schreiber, John K Forrest, Tanvir K Bajwa, Daniel P O'Hair, George Petrossian, Newell Robinson, Stanley Katz, Alan Hartman, Harold L Dauerman, Joseph Schmoker, Kamal Khabbaz, Daniel R Watson, Steven J Yakubov, Jae K Oh, Shuzhen Li, Neal S Kleiman, David H Adams, Jeffrey J Popma
OBJECTIVES: This study evaluated the safety and effectiveness of self-expanding transcatheter aortic valve replacement (TAVR) in patients with surgical valve failure (SVF). BACKGROUND: Self-expanding TAVR is superior to medical therapy for patients with severe native aortic valve stenosis at increased surgical risk. METHODS: The CoreValve U.S. Expanded Use Study was a prospective, nonrandomized study that enrolled 233 patients with symptomatic SVF who were deemed unsuitable for reoperation...
May 22, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28506942/insights-into-the-need-for-permanent-pacemaker-following-implantation-of-the-repositionable-lotus%C3%A2-valve-for-the-transcatheter-aortic-valve-replacement-in-250-patients-results-from-the-reprise-ii-trial-with-extended-cohort
#9
Nicolas Dumonteil, Ian T Meredith, Daniel J Blackman, Didier Tchétché, David Hildick-Smith, Mark S Spence, Darren L Walters, Jan Harnek, Stephen G Worthley, Gilles Rioufol, Thierry Lefèvre, Thomas Modine, Nicolas Van Mieghem, Vicki M Houle, Dominic J Allocco, Keith D Dawkins
AIMS: This analysis evaluated the incidence and predictors of the need for permanent pacemaker (PPM) implantation following implantation of the repositionable and fully retrievable Lotus Aortic Valve Replacement System. METHODS & RESULTS: The prospective, single arm, multicentre REPRISE II study with extended cohort enrolled 250 symptomatic, high surgical risk patients with severe aortic stenosis for transfemoral transcatheter aortic valve implantation (TAVI) with a 23mm or 27mm Lotus Valve...
May 16, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28501374/the-effect-of-the-superior-cavopulmonary-anastomosis-on-ventricular-remodeling-in-infants-with-single-ventricle
#10
Renee Margossian, Victor Zak, Amanda J Shillingford, Anthony M Hlavacek, James F Cnota, Michael D Puchalski, Jami C Levine, Brian W McCrindle, Meryl S Cohen, Karen Altmann, Piers C Barker, Daphne T Hsu, Steven D Colan
BACKGROUND: Infants with single ventricular physiology have volume and pressure overload that adversely affect ventricular mechanics. The impact of superior cavopulmonary anastomosis (SCPA) on single left ventricles versus single right ventricles is not known. METHODS: As part of the Pediatric Heart Network placebo-controlled trial of enalapril in infants with single ventricular physiology, echocardiograms were obtained before SCPA and at 14 months and analyzed in a core laboratory...
May 10, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28453629/long-term-outcomes-of-a-rapid-deployment-aortic-valve-data-up-to-5-years%C3%A2
#11
Günther Laufer, Axel Haverich, Martin Andreas, Friedrich W Mohr, Thomas Walther, Malakh Shrestha, Parwis Rahmanian, David Holzhey, Matthias Roth, Christoph Schmitz, René Schramm, Christophe Giot, Thorsten C W Wahlers
OBJECTIVES: Rapid deployment aortic valve replacement (AVR) has been developed to facilitate minimally invasive approaches for cardiac surgery and shorten procedural times. TRITON is a prospectively designed study to assess safety and efficacy of rapid deployment AVR with Edwards INTUITY valve system. This report presents the 5-year outcomes of the TRITON trial. METHODS: A total of 295 patients with aortic valve stenosis were enrolled in the TRITON trial and 287 patients received the study valve...
April 26, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28451658/transformation-from-single-mesoporous-to-dual-mesoporous-organosilica-nanoparticles
#12
Xue Wang, Libo Zhou, Yunling Liu, Shengyan Yin, Zhen-An Qiao, Qisheng Huo
Transformation from single-mesoporous to dual-mesoporous structured organosilica nanoparticles can be achieved by simply varying the volume fraction of ethanol in the synthesis system, using lauryl sulfonate betaine and sodium dodecyl sulfonate as dual-templates. Core-shell structured dual-mesoporous organosilica nanoparticles possess smaller mesopores (4.0 nm) in the shell and flower-like larger mesopores (46 nm) in the core. Owing to the unique mesostructure, dual-mesoporous organosilica nanoparticles show a high loading capacity and a slow release rate for cargo molecules...
May 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28430909/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#13
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28427582/clinical-trial-principles-and-endpoint-definitions-for-paravalvular-leaks-in-surgical-prosthesis-an-expert-statement
#14
REVIEW
Carlos E Ruiz, Rebecca T Hahn, Alain Berrebi, Jeffrey S Borer, Donald E Cutlip, Greg Fontana, Gino Gerosa, Reda Ibrahim, Vladimir Jelnin, Hasan Jilaihawi, E Marc Jolicoeur, Chad Kliger, Itzhak Kronzon, Jonathon Leipsic, Francesco Maisano, Xavier Millan, Patrick Nataf, Patrick T O'Gara, Philippe Pibarot, Stephen R Ramee, Charanjit S Rihal, Josep Rodes-Cabau, Paul Sorajja, Rakesh Suri, Julie A Swain, Zoltan G Turi, E Murat Tuzcu, Neil J Weissman, Jose L Zamorano, Patrick W Serruys, Martin B Leon
The VARC (Valve Academic Research Consortium) for transcatheter aortic valve replacement set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness of transcatheter devices, and defining single and composite clinical endpoints for clinical trials. No such standardization exists for circumferentially sutured surgical valve paravalvular leak (PVL) closure. This document seeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used in clinical trials of PVL closure devices...
April 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28406475/depletion-of-polycomb-repressive-complex-2-core-component-eed-impairs-fetal-hematopoiesis
#15
Wenhua Yu, Fang Zhang, Shiyan Wang, Yi Fu, Jiahuan Chen, Xiaodong Liang, Huangying Le, William T Pu, Bing Zhang
Polycomb repressive complex 2 (PRC2), a H3K27me3 methyltransferase complex, promotes the development of many organs by silencing ectopic transcription program. However, currently little is known about the role of PRC2 in blood and vascular development. In this study, we interrogated the function of embryonic ectoderm development (EED), a core PRC2 component, in both endothelial and hematopoietic tissues by inactivating a floxed murine EED allele with Tie2Cre, which catalyzes recombination in endothelial and hematopoietic lineages...
April 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28400461/matched-comparison-of-self-expanding-transcatheter-heart-valves-for-the-treatment-of-failed-aortic-surgical-bioprosthesis-insights-from-the-valve-in-valve-international-data-registry-vivid
#16
MULTICENTER STUDY
Sami Alnasser, Asim N Cheema, Matheus Simonato, Marco Barbanti, Jeremy Edwards, Ran Kornowski, Eric Horlick, Harindra C Wijeysundera, Luca Testa, Francesco Bedogni, Hafid Amrane, Thomas Walther, Marc Pelletier, Azeem Latib, Jean-Claude Laborde, David Hildick-Smith, Won-Keun Kim, Didier Tchetche, Marco Agrifoglio, Jan-Malte Sinning, Ad J van Boven, Joëlle Kefer, Christian Frerker, Nicolas M van Mieghem, Axel Linke, Stephen Worthley, Anita Asgar, Carmelo Sgroi, Mina Aziz, Haim D Danenberg, Marino Labinaz, Ganesh Manoharan, Anson Cheung, John G Webb, Danny Dvir
BACKGROUND: Transcatheter valve-in-valve implantation is an established therapy for high-risk patients with failed surgical aortic bioprosthesis. There are limited data comparing outcomes of valve-in-valve implantation using different transcatheter heart valves (THV). METHODS AND RESULTS: Patients included in the Valve-in-Valve International Data registry (VIVID) and treated with self-expanding THV devices were analyzed using centralized core laboratory blinded to clinical events...
April 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28331573/evolution-of-the-spatula-alcatraz-gene-lineage-and-expression-analyses-in-the-basal-eudicot-bocconia-frutescens-l-papaveraceae
#17
Cecilia Zumajo-Cardona, Barbara Ann Ambrose, Natalia Pabón-Mora
BACKGROUND: SPATULA (SPT) and ALCATRAZ (ALC) are recent paralogs that belong to the large bHLH transcription factor family. Orthologs of these genes have been found in all core eudicots, whereas pre-duplication genes, named paleoSPATULA/ALCATRAZ, have been found in basal eudicots, monocots, basal angiosperms and gymnosperms. Nevertheless, functional studies have only been performed in Arabidopsis thaliana, where SPT and ALC are partially redundant in carpel and valve margin development and ALC has a unique role in the dehiscence zone...
2017: EvoDevo
https://www.readbyqxmd.com/read/28274243/presence-of-coxiella-burnetii-dna-in-inflamed-bovine-cardiac-valves
#18
Jørgen S Agerholm, Tim K Jensen, Jens F Agger, Marc Y Engelsma, Hendrik I J Roest
BACKGROUND: Bacterial endocarditis is a recognised disease in humans and animals. In humans, infection with Coxiella burnetii can cause endocarditis, but this has not been investigated thoroughly in animals. Endocarditis in cattle is a common post-mortem finding in abattoirs and studies have identified Trueperella pyogenes as a major cause. Despite exposure of cattle to C. burnetii, the significance of this particular bacterium for development and progression of endocarditis has not been studied in detail...
March 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28238245/rheumatic-fever-and-rheumatic-heart-disease-collaboration-patterns-and-research-core-topics
#19
Alejandro Salinas, Gregorio González, Jose Manuel Ramos
BACKGROUND: Rheumatic fever and rheumatic heart disease (RHD) are important health problems in developing countries. The study aim was to provide a review and content analysis of the scientific literature on rheumatic fever and RHD over a 70-year period. METHODS: Medline was employed via the online PubMed service of the US National Library of Medicine, to search for all documents containing the MeSH terms 'rheumatic fever' or 'rheumatic heart disease' between January 1945 and December 2013...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28219920/impact-of-coronary-artery-disease-severity-assessed-with-the-syntax-score-on-outcomes-following-transcatheter-aortic-valve-replacement
#20
Jean-Michel Paradis, Jonathon M White, Philippe Généreux, Marina Urena, Darshan Doshi, Tamim Nazif, Rebecca Hahn, Isaac George, Omar Khalique, Kishore Harjai, Laura Lasalle, Benoit M Labbé, Robert DeLarochellière, Daniel Doyle, Éric Dumont, Siamak Mohammadi, Martin B Leon, Josep Rodés-Cabau, Susheel Kodali
BACKGROUND: The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. METHODS AND RESULTS: A total of 377 patients who underwent TAVR in 2 high-volume centers in North America were included in our retrospective analysis. A blinded angiographic core laboratory calculated the SS on all available coronary angiograms with the use of quantitative coronary analysis...
February 20, 2017: Journal of the American Heart Association
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