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https://www.readbyqxmd.com/read/29741615/the-incidence-and-prognostic-implications-of-worsening-right-ventricular-function-after-surgical-or-transcatheter-aortic-valve-replacement-insights-from-partner-iia
#1
Paul C Cremer, Yiran Zhang, Maria Alu, L Leonardo Rodriguez, Brian R Lindman, Alan Zajarias, Rebecca T Hahn, Stamatios Lerakis, S Chris Malaisrie, Pamela S Douglas, Philippe Pibarot, Lars G Svensson, Martin B Leon, Wael A Jaber
Aims: In patients randomized to transcatheter or surgical aortic valve replacement (TAVR, SAVR), we sought to determine whether SAVR is associated with worsening right ventricular (RV) function and whether RV deterioration is associated with mortality. Methods and results: In 1376 patients from PARTNERIIA with paired baseline and 30-day core lab echocardiograms, worsening RV function was defined as decline by at least one grade from baseline to 30 days. Our primary outcome was all-cause mortality from 30 days to 2 years...
May 8, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29741488/long-term-durability-and-hemodynamic-performance-of-a-self-expanding-transcatheter-heart-valve-beyond-5-years-after-implantation-a-prospective-observational-study-applying-the-standardized-definitions-of-structural-deterioration-and-valve-failure
#2
Erik W Holy, Julia Kebernik, Mohammad Abdelghani, Simon F Stämpfli, Jens Hellermann, Abdelhakim Allali, Mohamed El-Mawardy, Susanne Sachse, Thomas F Lüscher, Felix C Tanner, Gert Richardt, Mohamed Abdel-Wahab
AIMS: Long-term results of transcatheter aortic valve implantation (TAVI), in particular the incidence of bioprosthetic valve failure (BVF), are uncertain. METHODS AND RESULTS: The study prospectively included all 152 patients who had undergone TAVI with the self-expanding CoreValve™ up to December 2011 at the Heart Center, Bad Segeberg, Germany. Late BVF (>30 days) was defined as either: 1) Severe structural valve deterioration (trans-prosthetic mean pressure gradient ≥40 mmHg and/or ≥20 mmHg rise from baseline OR severe intra-prosthetic aortic regurgitation), OR 2) Bioprosthetic valve dysfunction leading to death or re-intervention...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29735255/computed-tomography-predictors-of-mortality-stroke-and-conduction-disturbances-in-women-undergoing-tavr-a-sub-analysis-of-the-win-tavi-registry
#3
Marco Spaziano, Alaide Chieffo, Yusuke Watanabe, Jaya Chandrasekhar, Samantha Sartori, Thierry Lefèvre, Anna Sonia Petronio, Patrizia Presbitero, Didier Tchetche, Alessandro Iadanza, Nicholas M Van Mieghem, Julinda Mehilli, Roxana Mehran, Marie-Claude Morice
BACKGROUND: Aortic valve calcification patterns were associated with short- and long-term outcomes in previous small observational datasets of patients undergoing transcatheter aortic valve implantation (TAVI). The specific impact of multi detector-row computed tomography (MDCT) findings on outcomes in women has not been reported. We sought to describe the associations between MDCT characteristics and clinical outcomes in a registry of 547 women undergoing TAVI. METHODS: WIN-TAVI is the first all-female registry to study the safety and effectiveness of TAVI in women (n = 1019)...
April 27, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29713288/3d-fluid-structure-interaction-simulation-of-aortic-valves-using-a-unified-continuum-ale-fem-model
#4
Jeannette H Spühler, Johan Jansson, Niclas Jansson, Johan Hoffman
Due to advances in medical imaging, computational fluid dynamics algorithms and high performance computing, computer simulation is developing into an important tool for understanding the relationship between cardiovascular diseases and intraventricular blood flow. The field of cardiac flow simulation is challenging and highly interdisciplinary. We apply a computational framework for automated solutions of partial differential equations using Finite Element Methods where any mathematical description directly can be translated to code...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29704125/enlargement-of-sacral-subcutaneous-meningocele-associated-with-retained-medullary-cord
#5
Noritoshi Shirozu, Takato Morioka, Satoshi Inoha, Naoyuki Imamoto, Takakazu Sasaguri
BACKGROUND: A retained medullary cord (RMC) is a rare closed spinal dysraphism with a robust elongated neural structure continuous from the conus and extending to the dural cul-de-sac. Four cases of RMC extending down to the base of an associated subcutaneous meningocele at the sacral level have been reported. CLINICAL PRESENTATION: We report an additional case of RMC, in whom serial MRI examination revealed an enlargement of the meningocele associated with RMC over a 3-month period between 8 and 11 months of age, when he began to stand...
April 27, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29688174/matched-comparison-of-next-and-early-generation-balloon-expandable-transcatheter-heart-valve-implantations-in-failed-surgical-aortic-bioprostheses
#6
Moritz Seiffert, Hendrik Treede, Joachim Schofer, Axel Linke, Jochen Woehrle, Hardy Baumbach, Julinda Mehilli, Vinayak Bapat, Matheus Simonato, Thomas Walther, Mathias Kullmer, Peter Boekstegers, Stephan Ensminger, Thomas Kurz, Hélène Eltchaninoff, Ardawan Rastan, Nicolas Werner, Arend de Weger, Christian Frerker, Bernward Lauer, Olivier Muller, Brian Whisenant, Arun Thukkani, Giora Weisz, Danny Dvir
AIMS: Transcatheter valve-in-valve implantation (VinV) is established for the treatment of degenerated surgical bioprostheses in patients at high operative risk. Our aim was to report on the first large assessment of VinV with next generation balloon-expandable transcatheter heart valves. METHODS AND RESULTS: 514 patients after SAPIEN XT or SAPIEN 3 VinV were analyzed using an inverse probability of treatment weighting. Standardized clinical and hemodynamic outcomes were compared and core laboratory evaluation of implantation depth was performed...
April 24, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29622987/outcome-of-transcatheter-aortic-valve-implantation-in-high-risk-patients-with-severe-aortic-stenosis
#7
Hamdy Soliman, Khlid Alrabaat, Tarek Aboalaazm, Shaimaa Mostafa, Asaad Samy
Aim: To assess outcome of TAVI in high risk patients with severe symptomatic aortic stenosis. Patients and methods: 40 patients with symptomatic severe aortic stenosis and high risk underwent TAVI with implantation of either Sapien XT valve or Core Valve and followed for 6 months. Device success, cardiovascular mortality, myocardial infarction, stroke, life-threatening bleeding and vascular complications were defined according to Valve Academic Research Consortium definitions...
December 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29599990/patients-experiences-of-the-transcatheter-aortic-valve-implantation-trajectory-a-grounded-theory-study
#8
Karin Olsson, Ulf Näslund, Johan Nilsson, Åsa Hörnsten
Aim: The aim of this study was to explore how patients experienced the recovery process from transcatheter aortic valve implantation. Design: A qualitative approach where in-depth interviews were used. Method: Eleven men and eight women undergoing transcatheter aortic valve implantation were individually interviewed 6 months after transcatheter aortic valve implantation. Grounded theory was used for the analysis. Results: The analysis generated the core concept "A journey of balancing between life-struggle and hope" connected to descriptive, bipolar categories...
April 2018: Nursing Open
https://www.readbyqxmd.com/read/29530883/hemodynamic-and-echocardiographic-comparison-of-the-lotus-and-corevalve-transcatheter-aortic-valves-in-patients-with-high-and-extreme-surgical-risk-an-analysis-from-the-reprise-iii-randomized-controlled-trial-repositionable-percutaneous-replacement-of-stenotic
#9
Federico M Asch, Mani A Vannan, Siddharth Singh, Bijoy Khandheria, Stephen H Little, Dominic J Allocco, Ian T Meredith, Ted E Feldman, Michael J Reardon, Neil J Weissman
BACKGROUND : Comparative echocardiographic data on transcatheter aortic valve replacement systems from randomized trials are limited. The REPRISE III trial (Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of Lotus Valve System - Randomized Clinical Evaluation) is a multicenter, randomized comparison of a mechanically expanded (Lotus) versus self-expanding (CoreValve) transcatheter aortic valve replacement device. This analysis rigorously assesses Doppler-derived valve hemodynamics and the impact on outcomes at 1 year in patients with extreme/high surgical risk treated with Lotus and CoreValve from REPRISE III...
March 12, 2018: Circulation
https://www.readbyqxmd.com/read/29495846/an-efficient-laser-vaporization-source-for-chemically-modified-metal-clusters-characterized-by-thermodynamics-and-kinetics
#10
Tsugunosuke Masubuchi, Jan F Eckhard, Kathrin Lange, Bradley Visser, Martin Tschurl, Ulrich Heiz
A laser vaporization cluster source that has a room for cluster aggregation and a reactor volume, each equipped with a pulsed valve, is presented for the efficient gas-phase production of chemically modified metal clusters. The performance of the cluster source is evaluated through the production of Ta and Ta oxide cluster cations, Tax Oy + (y ≥ 0). It is demonstrated that the cluster source produces Tax Oy + over a wide mass range, the metal-to-oxygen ratio of which can easily be controlled by changing the pulse duration that influences the amount of reactant O2 introduced into the cluster source...
February 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29467474/an-in-vitro-proof-of-principle-study-of-sonobactericide
#11
Kirby R Lattwein, Himanshu Shekhar, Willem J B van Wamel, Tammy Gonzalez, Andrew B Herr, Christy K Holland, Klazina Kooiman
Infective endocarditis (IE) is associated with high morbidity and mortality rates. The predominant bacteria causing IE is Staphylococcus aureus (S. aureus), which can bind to existing thrombi on heart valves and generate vegetations (biofilms). In this in vitro flow study, we evaluated sonobactericide as a novel strategy to treat IE, using ultrasound and an ultrasound contrast agent with or without other therapeutics. We developed a model of IE biofilm using human whole-blood clots infected with patient-derived S...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444998/treatment-of-aortic-stenosis-with-a-self-expanding-resheathable-transcatheter-valve-one-year-results-of-the-international-multicenter-portico-transcatheter-aortic-valve-implantation-system-study
#12
Axel Linke, David Holzhey, Helge Möllmann, Ganesh Manoharan, Ulrich Schäfer, Christian Frerker, Stephen G Worthley, A J van Boven, Simon Redwood, Jan Kovac, Christian Butter, Lars Søndergaard, Alexander Lauten, Gerhard Schymik, Thomas Walther
BACKGROUND: The aim of the Portico TAVI (transcatheter aortic valve implantation) system study was to evaluate outcomes ≤1 year after implantation of a novel resheathable, self-expanding TAVI system in a multicenter patient population with severe aortic stenosis (AS). METHODS AND RESULTS: High-risk patients (n=222) with symptomatic severe AS (mean age, 83.0±4.6 years; 74.3% women) were enrolled across 12 centers in Europe and Australia. The study's primary end point was all-cause mortality at 30 days...
February 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29428621/the-congenital-heart-surgeon-s-society-complete-atrioventricular-septal-defect-cohort-baseline-preintervention-echocardiographic-characteristics
#13
James M Meza, Paul J Devlin, David M Overman, David Gremmels, Gina Baffa, Meryl S Cohen, Michael D Quartermain, Christopher A Caldarone, Kamal Pourmoghadam, William M DeCampli, Cheryl T Fackoury, Luc Mertens
Quantifying unbalance, the threshold for single ventricle palliation vs biventricular repair in patients with unbalanced complete atrioventricular septal defect (AVSD), is challenging. Using a core laboratory review of baseline echocardiograms, we sought to assess the correlations among commonly used measures of unbalance and common atrioventricular valve (AVV) and ventricular sizes. A single reviewer evaluated baseline echocardiograms from an inception cohort of babies < age 1 year with complete AVSD admitted to 1 of 25 Congenital Heart Surgeon's Society institutions...
February 8, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29390856/formation-of-he-4-via-electron-impact-of-helium-droplets
#14
Jordan Fine, Deepak Verma, Curtis F Jones, Curt Wittig, Andrey F Vilesov
Electron impact ionization of superfluid helium droplets containing several thousand atoms produces a broad distribution of Hen + ions that peaks at n = 2 and decreases monotonically toward larger n. In larger droplets (say 105 or more atoms), however, the He4 + signal intensity is anomalously large. We have studied the mechanism for the formation of He4 + ions in large helium droplets by varying the duration of the electron impact excitation pulse. Droplets of different average sizes were generated using the expansion of helium at 20 bars and 9-20 K through a pulsed valve nozzle...
January 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29348010/early-outcomes-with-the-evolut-pro-repositionable-self-expanding-transcatheter-aortic-valve-with-pericardial-wrap
#15
John K Forrest, Abeel A Mangi, Jeffrey J Popma, Kamal Khabbaz, Michael J Reardon, Neal S Kleiman, Steven J Yakubov, Daniel Watson, Susheel Kodali, Isaac George, Peter Tadros, George L Zorn, John Brown, Robert Kipperman, Sara Saul, Hongyan Qiao, Jae K Oh, Mathew R Williams
OBJECTIVES: This study sought to evaluate the Medtronic Evolut PRO Transcatheter Aortic Valve System in patients with severe symptomatic aortic stenosis. BACKGROUND: A next-generation self-expanding transcatheter aortic valve was designed with an external pericardial wrap with the intent to reduce paravalvular leak while maintaining the benefits of a low-profile, self-expanding, and repositionable supra-annular valve. METHODS: The Medtronic Evolut PRO Clinical Study included 60 patients undergoing transcatheter aortic valve replacement with the Evolut PRO valve at 8 investigational sites in the United States...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29348006/importance-of-contrast-aortography-with-lotus-transcatheter-aortic-valve-replacement-a-post-hoc-analysis-from-the-respond-post-market-study
#16
Lennart van Gils, Jochen Wöhrle, David Hildick-Smith, Sabine Bleiziffer, Daniel J Blackman, Mohamed Abdel-Wahab, Ulrich Gerckens, Stephen Brecker, Vinayak Bapat, Thomas Modine, Osama I Soliman, Andrey Nersesov, Dominic Allocco, Volkmar Falk, Nicolas M Van Mieghem
OBJECTIVES: The aim of this post hoc analysis from the RESPOND (Repositionable Lotus Valve System-Post-Market Evaluation of Real World Clinical Outcomes) post-market study was to assess the final implantation depth on the contrast aortogram after Lotus valve (Boston Scientific, Marlborough, Massachusetts) transcatheter aortic valve replacement (TAVR) and to correlate with permanent pacemaker implantation (PPI) and paravalvular leak (PVL). BACKGROUND: Contrast aortography allows for the assessment of implantation depth and PVL during and after TAVR...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29289632/prognostic-impact-of-left-ventricular-ejection-fraction-in-patients-with-severe-aortic-stenosis
#17
Tomohiko Taniguchi, Takeshi Morimoto, Hiroki Shiomi, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Kazushige Kadota, Chisato Izumi, Kenji Nakatsuma, Tomoki Sasa, Hirotoshi Watanabe, Yasuhide Kuwabara, Takeru Makiyama, Koh Ono, Satoshi Shizuta, Takao Kato, Naritatsu Saito, Kenji Minatoya, Takeshi Kimura
OBJECTIVES: The aim of this study was to evaluate the prognostic impact of left ventricular ejection fraction (LVEF) in patients with severe aortic stenosis (AS). BACKGROUND: The prognostic impact of LVEF in severe AS remains controversial. METHODS: Among 3,815 consecutive patients with severe AS enrolled in the CURRENT AS (Contemporary Outcomes After Surgery and Medical Treatment in Patients With Severe Aortic Stenosis) registry, the present study population consisted of 3,794 patients after excluding 21 patients without LVEF data...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29283917/anesthetic-management-and-procedural-outcomes-of-patients-undergoing-off-pump-transapical-implantation-of-artificial-chordae-to-correct-mitral-regurgitation-case-series-of-76-patients
#18
Robertas Stasys Samalavicius, Ieva Norkiene, Agne Drasutiene, Arturas Lipnevicius, Vilius Janusauskas, Karolis Urbonas, Diana Zakarkaite, Audrius Aidietis, Kestutis Rucinskas
BACKGROUND: Transapical implantation of artificial chordae using the NeoChord system (NeoChord Inc, Minneapolis, MN) is an emerging beating-heart technique for correction of mitral regurgitation (MR) through a minimally invasive left minithoracotomy. The purpose of the study was to describe the anesthetic management and procedural success of patients undergoing this procedure. METHODS: All patients (n = 76) who underwent mitral valve repair with the NeoChord system in our institution from December 2011 to December 2016 were included in this observational prospective study...
March 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29244962/expression-of-the-frizzled-receptors-and-their-co-receptors-in-calcified-human-aortic-valves
#19
Ateeque Siddique, Bin Yu, Kashif Khan, Ryan Buyting, Hamood Al-Kindi, Hossny Alaws, Eric Rhéaume, Jean-Claude Tardif, Renzo Cecere, Adel Schwertani
The cellular mechanisms that induce calcific aortic stenosis are yet to be unraveled. Wnt signaling is increasingly being considered as a major player in the disease process. However, the presence of Wnt Frizzled (Fzd) receptors and co-receptors LRP5 and 6 in normal and diseased human aortic valves remains to be elucidated. Immunohistochemistry and quantitative polymerase chain reaction were used to determine Fzd receptor expression in normal and calcified human aortic valve tissue, as well as human aortic valve interstitial cells (HAVICs) isolated from calcified and normal human aortic valves...
February 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28988424/maintenance-of-valvular-integrity-with-impella-left-heart-support-results-from-the-multicenter-protect-ii-randomized-study
#20
James A Goldstein, Simon R Dixon, Pamela S Douglas, E Magnus Ohman, Jeffrey Moses, Jeffrey J Popma, William W O'Neill
BACKGROUND: The Impella 2.5 axial flow pump, which is positioned across the aortic valve, is widely employed for hemodynamic support. The present study compared structural and functional integrity of the left heart valves in patients undergoing Impella vs intra-aortic balloon pump in the randomized PROTECT II trial. METHODS AND RESULTS: Transthoracic echocardiograms were performed at baseline, 1 and 3 months in 445 patients in the PROTECT II trial. Serial studies were analyzed by an independent echocardiography core laboratory for aortic and mitral valve structure and function, and left ventricular ejection fraction (LVEF)...
October 8, 2017: Catheterization and Cardiovascular Interventions
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