Morgan R Peltier, Jennifer Behbodikhah, Heather A Renna, Saba Ahmed, Ankita Srivastava, Yuko Arita, Lora J Kasselman, Aaron Pinkhasov, Thomas Wisniewski, Joshua De Leon, Allison Bethanne Reiss
Dysregulated cholesterol metabolism represents an increasingly recognized feature of Autism spectrum disorder (ASD). Children with fetal valproate syndrome caused by prenatal exposure to valproic acid (VPA), an anti-epileptic and mood-stabilizing drug, have a higher incidence of developing ASD. However, the role of VPA in cholesterol homeostasis in neurons and microglial cells remains unclear. Therefore, we examined the effect of VPA exposure on regulation of cholesterol homeostasis in the human microglial clone 3 (HMC3) cell line and the human neuroblastoma cell line SH-SY5Y...
October 21, 2023: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research