keyword
MENU ▼
Read by QxMD icon Read
search

Daniels and ischemia

keyword
https://www.readbyqxmd.com/read/28090786/inorganic-nitrite-modulates-mirna-signatures-in-acute-myocardial-in-vivo-ischemia-reperfusion
#1
Ulrike B Hendgen-Cotta, Daniel Messiha, Sonja Esfeld, René Deenen, Tienush Rassaf, Matthias Totzeck
Acute myocardial infarction is the leading cause of mortality in the industrialized world. While it is essential to attempt an early reperfusion of ischemic myocardial territories, reperfusion itself adds damage to the heart, the ischemia-reperfusion (I/R) injury. Particularly the injury resulting from the very first minutes of reperfusion remains incompletely understood. MicroRNAs (miRNAs) are dynamic regulators in I/R injury. Nitric oxide (•NO) signaling, in turn, interacts with miRNA signaling. Our previous investigations showed that •NO signaling in I/R could be modulated by nitrite...
January 16, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28088802/interplay-between-cortical-spreading-depolarization-and-seizures
#2
Daniel R Kramer, Tatsuhiro Fujii, Ifije Ohiorhenuan, Charles Y Liu
Cortical spreading depolarization (CSD) is an electrophysiologic phenomenon found mostly in the setting of neurologic injury resulting in the disturbance of ion homeostasis and leading to changes in the local vascular response. The bioelectric etiology of CSD shares similarities to those in epileptic disorders, yet the relationship between seizures and CSD is unclear, with several studies observing cortical depression before, during, and after seizure activity, thus obscuring our understanding of whether CSD activity potentiates or limits seizures and vice versa...
January 14, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28081214/cold-pressor-stress-cardiac-magnetic-resonance-myocardial-flow-reserve-is-not-useful-for-detection-of-coronary-endothelial-dysfunction-in-women-with-signs-and-symptoms-of-ischemia-and-no-obstructive-cad
#3
Sofy Landes, Sherwin Dela Cruz, Janet Wei, Ahmed AlBadri, Chrisandra Shufelt, Puja Mehta, Louise E Thomson, Marcio A Diniz, Xiao Zhang, John W Petersen, R David Anderson, Carl J Pepine, Daniel S Berman, C Noel Bairey Merz
BACKGROUND: Coronary endothelial function testing using acetylcholine is not routinely available, while non-pharmacological cold pressor testing (CPT) is considered an endothelial stressor. Noninvasive cardiac magnetic resonance imaging (CMRI) myocardial perfusion reserve index (MPRI) can detect coronary microvascular dysfunction (CMD). We evaluated if CPT stress CMRI MPRI could detect invasive coronary endothelial dysfunction. METHODS: Coronary reactivity testing was performed in 189 women with symptoms and signs of ischemic but no obstructive coronary artery disease as previously described plus CPT stress...
2017: PloS One
https://www.readbyqxmd.com/read/28079433/pet-imaging-of-cannabinoid-type-2-receptors-with-11-c-a-836339-did-not-evidence-changes-following-neuroinflammation-in-rats
#4
Geraldine Pottier, Vanessa Gómez-Vallejo, Daniel Padro, Raphaël Boisgard, Frédéric Dollé, Jordi Llop, Alexandra Winkeler, Abraham Martín
Cannabinoid type 2 receptors (CB2R) have emerged as promising targets for the diagnosis and therapy of brain pathologies. However, no suitable radiotracers for accurate CB2R mapping have been found to date, limiting the investigation of the CB2 receptor expression using positron emission tomography (PET) imaging. In this work, we report the evaluation of the in vivo expression of CB2R with [(11)C]A-836339 PET after cerebral ischemia and in two rat models of neuroinflammation, first by intrastriatal LPS and then by AMPA injection...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28074603/supplementing-diet-with-manitoba-lingonberry-juice-reduces-kidney-ischemia-reperfusion-injury
#5
Cara K Isaak, Pengqi Wang, Suvira Prashar, Karmin O, Daniel C W Brown, Samir C Debnath, Yaw L Siow
BACKGROUND: Lingonberry (Vaccinium vitis-idaea L.) contains high levels of anthocyanins which are bioavailable in the kidney and may be protective against ischemia-reperfusion (IR)-induced acute kidney injury. This study investigated the effect of lingonberry juice on IR-induced stress-activated signaling pathway and inflammatory response in the kidney. RESULTS: Sprague-Dawley rats subjected to kidney IR had significantly impaired kidney function, with increased activation of the JNK signaling pathway and increased inflammatory response, measured using a multiplex panel containing an extensive array of inflammatory biomarkers...
January 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28065616/experience-on-mechanical-thrombectomy-for-acute-stroke-treatment-in-a-brazilian-university-hospital
#6
Guilherme S Nakiri, Luis H Castro-Afonso, Lucas M Monsignore, Francisco A Dias, Frederico F Alessio-Alves, Soraia Ramos C Fabio, Millene R Camilo, Pedro T Cougo-Pinto, Octavio M Pontes-Neto, João Pereira Leite, Daniel G Abud
BACKGROUND: Brazil is a developing country struggling to reduce its extreme social inequality, which is reflected on shortage of health-care infrastructure, mainly to the low-income class, which depends exclusively on the public health system. In Brazil, less than 1% of stroke patients have access to intravenous thrombolysis in a stroke unit, and constraints to the development of mechanical thrombectomy in the public health system increase the social burden of stroke. OBJECTIVE: Report the feasibility of mechanical thrombectomy as part of routine stroke care in a Brazilian public university hospital...
January 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28062895/3d-printed-renal-cancer-models-derived-from-mri-data-application-in-pre-surgical-planning
#7
Nicole Wake, Temitope Rude, Stella K Kang, Michael D Stifelman, James F Borin, Daniel K Sodickson, William C Huang, Hersh Chandarana
OBJECTIVE: To determine whether patient-specific 3D printed renal tumor models change pre-operative planning decisions made by urological surgeons in preparation for complex renal mass surgical procedures. MATERIALS AND METHODS: From our ongoing IRB approved study on renal neoplasms, ten renal mass cases were retrospectively selected based on Nephrometry Score greater than 5 (range 6-10). A 3D post-contrast fat-suppressed gradient-echo T1-weighted sequence was used to generate 3D printed models...
January 7, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28059967/actual-risk-of-using-very-aged-donors-for-unselected-liver-transplant-candidates-a-european-single-center-experience-in-the-meld-era
#8
Valentina Rosa Bertuzzo, Matteo Cescon, Federica Odaldi, Marco Di Laudo, Alessandro Cucchetti, Matteo Ravaioli, Massimo Del Gaudio, Giorgio Ercolani, Antonietta D'Errico, Antonio Daniele Pinna
OBJECTIVE: To evaluate the whole experience of liver transplantation (LT) with donors ≥70 years in a single center not applying specific donor/recipient matching criteria. BACKGROUND: LT with very old donors has historically been associated with poorer outcomes. With the increasing average donor age and the advent of Model for End-stage Liver Diseases (MELD) score-based allocation criteria, an optimal donor/recipient matching is often unsuitable. METHODS: Outcomes of all types of LTs were compared according to 4 study groups: patients transplanted between 1998 and 2003 with donors <70 (group 1, n = 396) or ≥70 years (group 2, n = 88); patients transplanted between 2004 and 2010 with donors <70 (group 3, n = 409), or ≥70 years (group 4, n = 190)...
February 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28025263/quantitative-plaque-features-from-coronary-computed-tomography-angiography-to-identify-regional-ischemia-by-myocardial-perfusion-imaging
#9
Mariana Diaz-Zamudio, Tobias A Fuchs, Piotr Slomka, Yuka Otaki, Reza Arsanjani, Heidi Gransar, Guido Germano, Daniel S Berman, Philipp A Kaufmann, Damini Dey
AIMS: We aimed to investigate whether quantitative plaque features measured from coronary CT angiography (CCTA) predict ischemia by myocardial perfusion SPECT imaging (MPI). METHODS AND RESULTS: Hundred and eighty-four consecutive patients (63% males) with suspected-coronary artery disease, undergoing hybrid CCTA, and attenuation corrected solid state (99m)Tc stress/rest MPI and single vessel ischemia were considered. Quantitative analysis of CCTA derived non-calcified plaque (NCP), low-density NCP [< 30 Hounsfield Units (HU)] (LDNCP), calcified and total plaque burdens (%, normalized to vessel volume), maximum diameter stenosis and contrast density difference (CD, maximum difference in HU/lumen area within lesion)...
December 26, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28009096/in-vivo-ischemia-detection-by-luminescent-nanothermometers
#10
Erving Clayton Ximendes, Uéslen Rocha, Blanca Del Rosal, Alberto Vaquero, Francisco Sanz-Rodríguez, Luis Monge, Fuqiang Ren, Fiorenzo Vetrone, Dongling Ma, José García-Solé, Carlos Jacinto, Daniel Jaque, Nuria Fernández
There is an urgent need to develop new diagnosis tools for real in vivo detection of first stages of ischemia for the early treatment of cardiovascular diseases and accidents. However, traditional approaches show low sensitivity and a limited penetration into tissues, so they are only applicable for the detection of surface lesions. Here, it is shown how the superior thermal sensing capabilities of near infrared-emitting quantum dots (NIR-QDs) can be efficiently used for in vivo detection of subcutaneous ischemic tissues...
December 23, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28000016/robotic-assisted-partial-nephrectomy-provides-better-operative-outcomes-as-compared-to-the-laparoscopic-and-open-approaches-results-from-a-prospective-cohort-study
#11
Lorenzo G Luciani, Stefano Chiodini, Daniele Mattevi, Tommaso Cai, Marco Puglisi, William Mantovani, Gianni Malossini
The objective of this is to compare the surgical outcomes of partial nephrectomy (PN), performed via three different approaches: robot-assisted (RAPN), laparoscopic (LPN), and open (OPN), in a single non-academic regional center. The data of patients undergoing PN at our Department from 2005 to 2016 were prospectively collected. A logistic regression model adjusted for preoperative variables (age, tumor size, creatinine and hemoglobin, ASA and Padua scores) was performed to evaluate whether transfusion, conversion, and postoperative complication rate were influenced by the surgical approach...
December 20, 2016: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/27993119/pathophysiology-of-myocardial-infarction-and-acute-management-strategies
#12
Daniel Petrovič, Miha Tibaut, Dušan Mekiš
Yearly, 13,2% of all deaths are attributable to coronary artery disease (CAD), which with 7.4 million deaths makes CAD leading cause of death in the world. In this review we discuss current knowledge in pathophysiology of atherosclerosis with its progression to stable CAD and its destabilization and complication with thrombus formation - myocardial infarction (MI). Next, we describe mechanisms of myocardial cell death in MI, ischemia-reperfusion injury, left-ventricular remodeling and complications of MI. Furthermore, we add acute management strategies concentrating on medical therapy, decision on reperfusion strategy, timing and cardiac protection by ischemic preconditioning, postconditioning and remote ischemic conditioning...
December 15, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27982159/comparative-study-between-perfusion-changes-and-positive-findings-on-coronary-flow-reserve
#13
Costantino Roberto Frack Costantini, Jose Antonio Ramires, Costantino Ortiz Costantini, Marcos Antonio Denk, Sergio Gustavo Tarbine, Marcelo de Freitas Santos, Daniel Aníbal Zanuttini, Carmen Weigert Silveira, Admar Moraes de Souza, Rafael Michel de Macedo
Background: Functional assessment of coronary artery obstruction is used in cardiology practice to correlate anatomic obstructions with flow decrease. Among such assessments, the study of the coronary fractional flow reserve (FFR) has become the most widely used. Objective: To evaluate the correlation between FFR and findings of ischemia obtained by noninvasive methods including stress echocardiography and nuclear medicine and the presence of critical coronary artery obstruction...
December 8, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27960536/oxidative-stress-induced-mir-200c-disrupts-the-regulatory-loop-among-sirt1-foxo1-and-enos
#14
Fabrizio Carlomosti, Marco D'Agostino, Sara Beji, Alessio Torcinaro, Roberto Rizzi, Germana Zaccagnini, Biagina Maimone, Valeria Di Stefano, Francesca De Santa, Sonia Cordisco, Annalisa Antonini, Roberta Ciarapica, Elena Dellambra, Fabio Martelli, Daniele Avitabile, Maurizio C Capogrossi, Alessandra Magenta
AIMS: Reactive oxygen species (ROS) play a pivotal role in different pathologic conditions including ischemia, diabetes and aging. We previously showed that ROS enhance miR-200c expression, causing endothelial cells (EC) apoptosis and senescence. Herein, we dissect the interaction among miR-200c and three strictly related proteins that modulate EC function and ROS production: Sirtuin 1 (SIRT1), endothelial nitric oxide synthase (eNOS) and forkhead box O1 (FOXO1). Moreover the role of miR-200c on ROS modulation was also investigated...
December 13, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27941354/the-endothelial-glycocalyx-and-perioperative-lung-injury
#15
Florian Brettner, Vera von Dossow, Daniel Chappell
PURPOSE OF REVIEW: Ventilator-induced lung injury is a major contributor to perioperative lung injury. The end-expiratory lung volume, regional lung overdistension, and tidal recruitment are known to be the main factors causing subsequent alveolar damage and inflammation. The alveolar-capillary membrane including the endothelial glycocalyx as an integral part of the vascular endothelium seems to play a major role in different kinds of lung injury. RECENT FINDINGS: Recent studies underline the pivotal importance of the endothelial glycocalyx in lung injury...
February 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27940009/no-protection-of-heart-kidneys-and-brain-by-remote-ischemic-preconditioning-before-transfemoral-transcatheter-aortic-valve-implantation-interim-analysis-of-a-randomized-single-blinded-placebo-controlled-single-center-trial
#16
Philipp Kahlert, Heike Annelie Hildebrandt, Polykarpos Christos Patsalis, Fadi Al-Rashid, Rolf Alexander Jánosi, Felix Nensa, Thomas Wilfried Schlosser, Marc Schlamann, Daniel Wendt, Matthias Thielmann, Eva Kottenberg, Ulrich Frey, Markus Neuhäuser, Michael Forsting, Heinz Günther Jakob, Tienush Rassaf, Jürgen Peters, Gerd Heusch, Petra Kleinbongard
BACKGROUND: Remote ischemic preconditioning (RIPC) reduces myocardial injury and improves clinical outcome in patients undergoing coronary revascularization, but only in the absence of propofol-anesthesia. We investigated whether RIPC provides protection of heart, kidneys and brain and improves outcome in patients undergoing transfemoral transcatheter aortic valve implantation (TF-TAVI). METHODS: Patients undergoing TF-TAVI were randomized to receive RIPC (3cycles of 5min left upper arm ischemia and 5min reperfusion) or placebo...
December 6, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27936928/use-of-main-renal-artery-clamping-predominates-over-minimal-clamping-techniques-during-robotic-partial-nephrectomy-for-complex-tumors
#17
Leedor Lieberman, Ravi Barod, Deepansh Dalela, Mireya Insua, Ronney Abaza, James Adshead, Rajesh Ahlawat, Benjamin Challacombe, Prokar Dasgupta, Giorgio Gandaglia, Daniel A Moon, Giacomo Novara, Francesco Porpiglia, Alexandre Mottrie, Mahendra Bhandari, Craig G Rogers
INTRODUCTION Hilar clamping is often performed to facilitate robotic partial nephrectomy (RPN). Minimal clamping techniques may reduce renal ischemia, including early unclamping, selective clamping, and off-clamp RPN. We assess the utilization of clamping techniques in a large international consortium of surgeons performing RPN for complex tumors. METHODS We retrospectively evaluated 721 patients with complex tumors who underwent RPN at 11 centers worldwide between 2008 and 2014. Complex tumors were defined as renal masses with a nephrometry score > 6...
December 9, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27932607/randomized-open-label-phase-1-2a-study-to-determine-the-maximum-tolerated-dose-of-intraventricular-sustained-release-nimodipine-for-subarachnoid-hemorrhage-newton-nimodipine-microparticles-to-enhance-recovery-while-reducing-toxicity-after-subarachnoid-hemorrhage
#18
Daniel Hänggi, Nima Etminan, Francois Aldrich, Hans Jakob Steiger, Stephan A Mayer, Michael N Diringer, Brian L Hoh, J Mocco, Herbert J Faleck, R Loch Macdonald
BACKGROUND AND PURPOSE: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal subarachnoid hemorrhage. METHODS: Subjects with aneurysmal subarachnoid hemorrhage repaired by clipping or coiling were randomized to EG-1962 or enteral nimodipine. Subjects were World Federation of Neurological Surgeons grade 2 to 4 and had an external ventricular drain...
January 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27927035/robotic-partial-nephrectomy-for-posterior-tumors-via-a-retroperitoneal-approach-offers-decreased-length-of-stay-compared-to-the-transperitoneal-approach-a-propensity-matched-analysis
#19
Matthew Joseph Maurice, Jihad Kaouk, Daniel Ramirez, Sam Bhayani, Mohamad E Allaf, Craig G Rogers, Michael D Stifelman
INTRODUCTION: We sought to compare surgical outcomes between transperitoneal and retroperitoneal robotic partial nephrectomy (RPN) for posterior tumors. PATIENTS AND METHODS: Using our multi-institutional RPN database, we reviewed 610 consecutive cases for posterior renal masses treated between 2007-2015. Primary outcomes were complications, operative time, length of stay (LOS), surgical margin status, and eGFR preservation. Secondary outcomes were estimated blood loss, warm ischemia time (WIT), disease recurrence, and disease-specific mortality...
December 7, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27914836/perioperative-retinal-artery-occlusion-risk-factors-in-cardiac-surgery-from-the-united-states-national-inpatient-sample-1998-2013
#20
Tyler Calway, Daniel S Rubin, Heather E Moss, Charlotte E Joslin, Katharina Beckmann, Steven Roth
PURPOSE: To study the incidence and risk factors for retinal artery occlusion (RAO) in cardiac surgery. DESIGN: Retrospective study using the National Inpatient Sample (NIS). METHODS: The NIS was searched for cardiac surgery. Retinal artery occlusion was identified by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Postulated risk factors based on literature review were included in multivariate logistic models...
November 30, 2016: Ophthalmology
keyword
keyword
9444
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"