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https://www.readbyqxmd.com/read/29127105/epor2-%C3%A3-cr2-independendent-effects-of-low-dose-epoetin-a-in-porcine-liver-transplantation
#1
Linus Kebschull, Leon Franz Christoph Theilmann, Annika Mohr, Wencke Uennigmann, Sandra Stoeppeler, Barbara Heitplatz, Hans-Ullrich Spiegel, Ralf Bahde, Daniel Michael Palmes, Felix Becker
Ischemia-reperfusion injury (IRI) remains the key component of graft damage during transplantation. Erythropoietin (EPO) induces anti-inflammatory and anti-apoptotic effects via the EPOR2/ßcR2-complex, with the potential risk of thrombosis. Previous work indicates that EPO has EPOR2/ßcR2-independent protective effects via direct effects on the endothelium. As the EPOR2/ßcR2-receptor has a very low affinity for EPO, we aimed to test the hypothesis that EPO doses below the level that stimulate this receptor elicit cytoprotective effects via endothelial stimulation in a porcine liver transplantation model...
November 10, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29126895/extracorporeal-membrane-oxygenation-in-circulatory-and-respiratory-failure-a-single-center-experience
#2
Marisa Passos Silva, Daniel Caeiro, Paula Fernandes, Cláudio Guerreiro, Eduardo Vilela, Marta Ponte, Adelaide Dias, Fernando Alves, Jorge Morais, Andreza Mello, Lino Santos, Paula Castelões, Vasco Gama
INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) provides mechanical pulmonary and circulatory support for patients with shock refractory to conventional medical therapy. In this study we aim to describe the indications, clinical characteristics, complications and mortality associated with use of ECMO in a single tertiary hospital. METHODS: We conducted a retrospective observational cohort study of all patients supported with ECMO in two different intensive care units (general and cardiac), from the first patient cannulated in April 2011 up to October 2016...
November 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29118800/septoplasty-scepter-balloon-angioplasty-for-vasospasm-after-aneurysmal-subarachnoid-hemorrhage
#3
Bradley A Gross, Daniel A Tonetti, Gregory M Weiner, David M Panczykowski, William J Ares, Cynthia L Kenmuir, Ashutosh P Jadhav, Tudor G Jovin, Brian T Jankowitz
Introduction: Balloon angioplasty can be a requisite approach for the treatment of symptomatic and/or severe vasospasm. Dual-lumen microcatheter balloons have multiple potential advantages for this indication including accommodating a 0.014-inch wire and the potential to deliver superselective vasodilators directly via the microcatheter prior to angioplasty. Methods: The authors reviewed a 3-year institutional experience with the Scepter XC balloon (Microvention, Tustin, CA, USA) in the treatment of postaneurysmal subarachnoid hemorrhage vasospasm, focusing on treatment methods, angiographic, and clinical results...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29110288/myocardial-perfusion-imaging-lessons-learned-and-work-to-be-done-update
#4
Ami E Iskandrian, Vasken Dilsizian, Ernest V Garcia, Rob S Beanlands, Manuel Cerqueira, Prem Soman, Daniel S Berman, Alberto Cuocolo, Andrew J Einstein, Charity J Morgan, Fadi G Hage, Heinrich R Schelbert, Jeroen J Bax, Joseph C Wu, Leslee J Shaw, Mehran M Sadeghi, Nagara Tamaki, Philipp A Kaufmann, Robert Gropler, Sharmila Dorbala, William Van Decker
As the second term of our commitment to Journal begins, we, the editors, would like to reflect on a few topics that have relevance today. These include prognostication and paradigm shifts; Serial testing: How to handle data? Is the change in perfusion predictive of outcome and which one? Ischemia-guided therapy: fractional flow reserve vs perfusion vs myocardial blood flow; positron emission tomography (PET) imaging using Rubidium-82 vs N-13 ammonia vs F-18 Flurpiridaz; How to differentiate microvascular disease from 3-vessel disease by PET? The imaging scene outside the United States, what are the differences and similarities? Radiation exposure; Special issues with the new cameras? Is attenuation correction needed? Are there normal databases and are these specific to each camera system? And finally, hybrid imaging with single-photon emission tomography or PET combined with computed tomography angiography or coronary calcium score...
November 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29107072/ectopic-phosphorylated-creb-marks-dedifferentiated-proximal-tubules-in-cystic-kidney-disease
#5
Pawan Puri, Caitlin M Schaefer, Daniel Bushnell, Mary E Taglienti, Jordan A Kreidberg, Bradley K Yoder, Carlton M Bates
Ectopic cAMP signaling is pathological in polycystic kidney disease; however, its spatio-temporal actions are unclear. We characterized expression of phosphorylated Creb (p-Creb), a target and mediator of cAMP signaling, in developing and cystic kidney models. We also examined tubule-specific effects of cAMP analogs in cystogenesis in embryonic kidney explants. In wild-type mice, p-Creb marked nephron progenitors (NP), early epithelial NP derivatives, ureteric bud, and cortical stroma; p-Creb was present in differentiated thick ascending limb of Henle, collecting duct, and stroma; however, it disappeared in mature NP-derived proximal tubules...
October 26, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29091756/enteroendocrine-l-cells-sense-lps-after-gut-barrier-injury-to-enhance-glp-1-secretion
#6
Lorène J Lebrun, Kaatje Lenaerts, Dorien Kiers, Jean-Paul Pais de Barros, Naig Le Guern, Jiri Plesnik, Charles Thomas, Thibaut Bourgeois, Cornelis H C Dejong, Matthijs Kox, Inca H R Hundscheid, Naim Akhtar Khan, Stéphane Mandard, Valérie Deckert, Peter Pickkers, Daniel J Drucker, Laurent Lagrost, Jacques Grober
Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that plasma GLP-1 levels are rapidly increased by lipopolysaccharide (LPS) administration in mice via a Toll-like receptor 4 (TLR4)-dependent mechanism. Experimental manipulation of gut barrier integrity after dextran sodium sulfate treatment, or via ischemia/reperfusion experiments in mice, triggered a rapid rise in circulating GLP-1...
October 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/29089437/transient-hypoxemia-chronically-disrupts-maturation-of-preterm-fetal-ovine-subplate-neuron-arborization-and-activity
#7
Evelyn McClendon, Daniel C Shaver, Kiera Degener-O'Brien, Xi Gong, Thuan Nguyen, Anna Hoerder-Suabedissen, Zoltán Molnár, Claudia Mohr, Ben D Richardson, David J Rossi, Stephen A Back
Preterm infants are at risk for a broad spectrum of neurobehavioral disabilities associated with diffuse disturbances in cortical growth and development. During brain development, subplate neurons (SPNs) are a largely transient population that serves a critical role to establish functional cortical circuits. By dynamically integrating into developing cortical circuits they assist in consolidation of intra and extracortical circuits. Although SPNs reside in close proximity to cerebral white matter, which is particularly vulnerable to oxidative stress, the susceptibility of SPNs remains controversial...
October 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29083088/clinical-applications-of-qt-rr-hysteresis-assessment-a%C3%A2-systematic-review
#8
REVIEW
Hugo Gravel, Vincent Jacquemet, Nagib Dahdah, Daniel Curnier
BACKGROUND: QT/RR hysteresis (QT-hys) is an index of the time accommodation of ventricular repolarization to heart rate changes. This report comprehensively reviews studies addressing QT-hys as a biomarker of medical conditions. METHODS: This is a secondary analysis of data from a recent systematic review pertaining to methods of assessment of QT-hys. Articles included in the former review were filtered in order to select original articles investigating the association of QT-hys with medical conditions in humans...
October 30, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29081724/role-of-stress-cardiac-magnetic-resonance-imaging-in-women-with-suspected-ischemia-but-no-obstructive-coronary-artery-disease
#9
Sawan Jalnapurkar, Parham Zarrini, Puja K Mehta, Louise E J Thomson, Megha Agarwal, Bruce A Samuels, Chrisandra L Shufelt, Jo-Ann Eastwood, Daniel Berman, Noel Bairey Merz, Margo B Minissian
OBJECTIVE: Signs and symptoms of ischemia but no obstructive coronary artery disease (CAD) is often a diagnostic dilemma in women. The use of stress cardiac magnetic resonance imaging (CMRI) for advanced diagnostic assessment in these patients is a non-ionizing radiation option, but the diagnostic utility in this population is unknown. We examined the diagnostic role of stress CMRI in our patient population of these women. METHODS: We analyzed 113 consecutive female patients from 2/2006-11/2007 who had prior cardiac evaluations for signs and symptoms of ischemia but no obstructive CAD who underwent stress CMRI, which included anatomic, functional, adenosine stress perfusion and delayed enhancement imaging...
September 2017: Journal of Radiology Nursing
https://www.readbyqxmd.com/read/29073603/vascular-endothelial-dysfunction-during-cardiac-surgery-on-pump-versus-off-pump-coronary-surgery
#10
Florian Brettner, Daniel Chappell, Lisa Schwartz, Alexander Lukasz, Philipp Kümpers, Bernhard F Becker, Bruno Reichart, Markus Rehm, Dirk Bruegger
BACKGROUND: Cardiac surgery often causes ischemia and development of a systemic inflammatory response syndrome, which impairs vascular barrier function, normally maintained by the endothelial cell line and the endothelial glycocalyx (EG). The EG normally covers and protects healthy endothelial cells throughout the vasculature. The aim of the present study was to assess the disruption of the cellular part of the microvascular barrier by determining parameters of endothelial cell activation known to influence and reflect cell-cell junctional integrity...
October 26, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29065463/protective-effect-of-prunus-cerasus-sour-cherry-seed-extract-on-the-recovery-of-ischemia-reperfusion-induced-retinal-damage-in-zucker-diabetic-fatty-rat
#11
Balázs Varga, Dániel Priksz, Nóra Lampé, Mariann Bombicz, Andrea Kurucz, Adrienn Mónika Szabó, Anikó Pósa, Renáta Szabó, Ádám Kemény-Beke, Judit Remenyik, Rudolf Gesztelyi, Béla Juhász
Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats...
October 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29023410/long-term-osmotic-mini-pump-treatment-with-alpha-msh-improves-myocardial-function-in-zucker-diabetic-fatty-rats
#12
Miklos Szokol, Daniel Priksz, Mariann Bombicz, Balazs Varga, Arpad Kovacs, Gabor Aron Fulop, Tamas Csipo, Aniko Posa, Attila Toth, Zoltan Papp, Zoltan Szilvassy, Bela Juhasz
The present investigation evaluates the cardiovascular effects of the anorexigenic mediator alpha-melanocyte stimulating hormone (MSH), in a rat model of type 2 diabetes. Osmotic mini pumps delivering MSH or vehicle, for 6 weeks, were surgically implanted in Zucker Diabetic Fatty (ZDF) rats. Serum parameters, blood pressure, and weight gain were monitored along with oral glucose tolerance (OGTT). Echocardiography was conducted and, following sacrifice, the effects of treatment on ischemia/reperfusion cardiac injury were assessed using the isolated working heart method...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29019146/spinal-cord-injury-after-thoracic-endovascular-aortic-aneurysm-repair
#13
Hamdy Awad, Mohamed Ehab Ramadan, Hosam F El Sayed, Daniel A Tolpin, Esmerina Tili, Charles D Collard
PURPOSE: Thoracic endovascular aortic aneurysm repair (TEVAR) has become a mainstay of therapy for aneurysms and other disorders of the thoracic aorta. The purpose of this narrative review article is to summarize the current literature on the risk factors for and pathophysiology of spinal cord injury (SCI) following TEVAR, and to discuss various intraoperative monitoring and treatment strategies. SOURCE: The articles considered in this review were identified through PubMed using the following search terms: thoracic aortic aneurysm, TEVAR, paralysis+TEVAR, risk factors+TEVAR, spinal cord ischemia+TEVAR, neuromonitoring+thoracic aortic aneurysm, spinal drain, cerebrospinal fluid drainage, treatment of spinal cord ischemia...
December 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28988940/dual-lumen-balloon-to-increase-onyx-venous-penetration-in-the-treatment-of-spinal-dural-arteriovenous-fistulas
#14
Felipe Padovani Trivelato, Marco Túlio Salles Rezende, Alexandre Cordeiro Ulhoa, Guilherme Seizem Nakiri, Daniel Giansante Abud
PURPOSE: Spinal dural arteriovenous fistulas (sDAVF) are the most common spinal vascular lesions. The arterialization of the recipient vein results in venous hypertension and chronic ischemia. Intravascular injection of acrylic glue in order to occlude the draining vein is the principle of endovascular treatment, but a significant portion of embolization procedures do not succeed. We present our initial experience of endovascular balloon augmented embolization of sDAVF using a dual-lumen balloon...
October 5, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28979690/multifaceted-effects-of-astragaloside-iv-on-promotion-of-random-pattern-skin-flap-survival-in-rats
#15
Renjin Lin, Huanwen Chen, Daniel Callow, Shihen Li, Lei Wang, Shi Li, Long Chen, Jian Ding, Weiyang Gao, Huazi Xu, Jianzhong Kong, Kailiang Zhou
Random pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery, but the distal part of skin flaps often suffers necrosis due to ischemia. Astragaloside IV (AS-IV), a natural saponin purified from Astragalus membranaceus, may have beneficial functions for flap survival. In this study, rats were divided into a control group and an AS-IV treatment group, and underwent surgery using a modified "McFarlane flap" model. After intragastric administration of vehicle control or AS-IV for their respective groups, flap survival area and water content were measured 7 days after surgery...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28973000/temporal-similarity-perfusion-mapping-a-standardized-and-model-free-method-for-detecting-perfusion-deficits-in-stroke
#16
Sunbin Song, Reinoud P H Bokkers, Marie Luby, Matthew A Edwardson, Tyler Brown, Shreyansh Shah, Robert W Cox, Ziad S Saad, Richard C Reynolds, Daniel R Glen, Leonardo G Cohen, Lawrence L Latour
INTRODUCTION: Interpretation of the extent of perfusion deficits in stroke MRI is highly dependent on the method used for analyzing the perfusion-weighted signal intensity time-series after gadolinium injection. In this study, we introduce a new model-free standardized method of temporal similarity perfusion (TSP) mapping for perfusion deficit detection and test its ability and reliability in acute ischemia. MATERIALS AND METHODS: Forty patients with an ischemic stroke or transient ischemic attack were included...
2017: PloS One
https://www.readbyqxmd.com/read/28968287/establishing-a-rodent-model-of-ventricular-fibrillation-cardiac-arrest-with-graded-histologic-and-neurologic-damage-with-different-cardiac-arrest-durations
#17
Florian Ettl, Ingrid A M Magnet, Wolfgang Weihs, Alexandra Warenits, Daniel Grassmann, Michael Wagner, Ursula Teubenbacher, Sandra Högler, Fritz Sterz, Andreas Janata
PURPOSE: To establish a ventricular fibrillation (VF) cardiac arrest (CA) resuscitation model with consistent neurologic and neuropathologic damage as potential therapeutic target. METHODS: Prospectively randomized groups of experiments in 2 phases. In phase 1 four groups of male Sprague-Dawley rats (n = 5) were resuscitated after 6 min VFCA with 2 and 6 min basic life support durations (BLS) with and without adrenaline. In phase 2 the most promising group regarding return of spontaneous circulation (ROSC) and survival was compared to a group of 8 min CA...
September 28, 2017: Shock
https://www.readbyqxmd.com/read/28966593/sphingosine-1-phosphate-receptor-modulator-fingolimod-fty720-attenuates-myocardial-fibrosis-in-post-heterotopic-heart-transplantation
#18
Naseer Ahmed, Daniele Linardi, Nazeer Muhammad, Cristiano Chiamulera, Guido Fumagalli, Livio San Biagio, Mebratu A Gebrie, Muhammad Aslam, Giovanni Battista Luciani, Giuseppe Faggian, Alessio Rungatscher
Background and Objective: Sphingosine 1-phosphate (S1P), and S1P receptor modulator fingolimod have been suggested to play important cardioprotective role in animal models of myocardial ischemia/reperfusion injuries. To understand the cardioprotective function of S1P and its mechanism in vivo, we analyzed apoptotic, inflammatory biomarkers, and myocardial fibrosis in an in vivo heterotopic rat heart transplantation model. Methods: Heterotopic heart transplantation is performed in 60 Sprague-Dawley (SD) rats (350-400 g)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28960957/in-vivo-neuroimaging-of-exosomes-using-gold-nanoparticles
#19
Oshra Betzer, Nisim Perets, Ariel Angel, Menachem Motiei, Tamar Sadan, Gal Yadid, Daniel Offen, Rachela Popovtzer
Exosomes are emerging as effective therapeutic tools for various pathologies. These extracellular vesicles can bypass biological barriers, including the blood-brain barrier, and can serve as powerful drug and gene therapy transporters. However, the progress of therapy development is impeded by several challenges, including insufficient data on exosome trafficking and biodistribution and the difficulty to image deep brain structures in vivo. Herein, we established a method for noninvasive in vivo neuroimaging and tracking of exosomes, based on glucose-coated gold nanoparticle (GNP) labeling and computed tomography imaging...
October 5, 2017: ACS Nano
https://www.readbyqxmd.com/read/28954531/is-off-clamp-always-beneficial-during-robotic-partial-nephrectomy-a-propensity-score-matched-comparison-of-clamp-technique-in-patients-with-two-kidneys
#20
Daniel C Rosen, David J Paulucci, Ronney Abaza, Daniel Eun, Akshay Bhandari, Ashok Hemal, Ketan K Badani
OBJECTIVE: The majority of patients undergoing partial nephrectomy (PN) present with a clinical T1a tumor with both kidneys present. Some groups have advocated using Off-Clamp (Off-C) techniques to eliminate warm ischemia whenever possible, even when elective. We evaluated whether Off-C technique during robotic PN (RPN) provides any functional benefit over main arterial clamping (MAC) in these patients. Subjects/Patients and Methods: 351 patients with a R.E.N.A.L. Nephrometry Score (RNS) <10, T1a tumor and two kidneys who underwent RPN from five high volume surgeons between 2008 and 2016 were retrospectively identified from a multi-institutional database...
September 27, 2017: Journal of Endourology
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