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https://www.readbyqxmd.com/read/29346781/laparoscopic-nephron-sparing-calycectomy-for-treating-fraley-s-syndrome
#1
Francesco Porpiglia, Riccardo Bertolo, Enrico Checcucci, Daniele Amparore, Matteo Manfredi, Cristian Fiori
Background/Aims/Objectives: Various nephron-sparing approaches were described as part of surgical management for Fraley's syndrome, a rare anatomic variant of the renal vascular anatomy that compresses the upper pole infundibulum resulting in an upper calyceal obstruction and dilatation, with symptoms of flank pain and hematuria. To date, descriptions of minimally invasive correction techniques are anecdotal. METHODS: A retroperitoneal pure laparoscopic approach using the nephron-sparing technique was chosen in the presented case...
January 18, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29342151/cd8-signaling-in-microglia-macrophage-m1-polarization-in-a-rat-model-of-cerebral-ischemia
#2
Jan Boddaert, Kenny Bielen, Bart 's Jongers, Ekta Manocha, Laetitia Yperzeele, Patrick Cras, Daniel Pirici, Samir Kumar-Singh
Classical or M1 activity of microglia/macrophages has been described in several neurodegenerative and brain inflammatory conditions and has also been linked to expansion of ischemic injury in post-stroke brain. While different pathways of M1 polarization have been suggested to occur in the post-stroke brain, the precise underlying mechanisms remain undefined. Using a transient middle cerebral artery occlusion (MCAO) rat model, we showed a progressive M2 to M1 polarization in the perilesional brain region with M1 cells becoming one of the dominant subsets by day 4 post-stroke...
2018: PloS One
https://www.readbyqxmd.com/read/29341964/renal-decapsulation-prevents-intrinsic-renal-compartment-syndrome-in-ischemia-reperfusion-induced-acute-kidney-injury-a-physiologic-approach
#3
Pablo Cruces, Pablo Lillo, Camila Salas, Tatiana Salomon, Felipe Lillo, Carlos González, Alejandro Pacheco, Daniel E Hurtado
OBJECTIVES: Acute kidney injury is a serious complication with unacceptably high mortality that lacks of specific curative treatment. Therapies focusing on the hydraulic behavior have shown promising results in preventing structural and functional renal impairment, but the underlying mechanisms remain understudied. Our goal is to assess the effects of renal decapsulation on regional hemodynamics, oxygenation, and perfusion in an ischemic acute kidney injury experimental model. METHODS: In piglets, intra renal pressure, renal tissue oxygen pressure, and dysoxia markers were measured in an ischemia-reperfusion group with intact kidney, an ischemia-reperfusion group where the kidney capsule was removed, and in a sham group...
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29335599/hindlimb-ischemia-impairs-endothelial-recovery-and-increases-neointimal-proliferation-in-the-carotid-artery
#4
Sabato Sorrentino, Claudio Iaconetti, Salvatore De Rosa, Alberto Polimeni, Jolanda Sabatino, Clarice Gareri, Francesco Passafaro, Teresa Mancuso, Laura Tammè, Chiara Mignogna, Caterina Camastra, Giovanni Esposito, Antonio Curcio, Daniele Torella, Ciro Indolfi
Peripheral ischemia is associated with higher degree of endothelial dysfunction and a worse prognosis after percutaneous coronary interventions (PCI). However, the role of peripheral ischemia on vascular remodeling in remote districts remains poorly understood. Here we show that the presence of hindlimb ischemia significantly enhances neointima formation and impairs endothelial recovery in balloon-injured carotid arteries. Endothelial-derived microRNAs are involved in the modulation of these processes. Indeed, endothelial miR-16 is remarkably upregulated after vascular injury in the presences of hindlimb ischemia and exerts a negative effect on endothelial repair through the inhibition of RhoGDIα and nitric oxide (NO) production...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335464/evaluation-of-endothelial-function-by-vop-and-inflammatory-biomarkers-in-patients-with-arterial-hypertension
#5
Camillo L C Junqueira, Maria Eliane C Magalhães, Andréa Araújo Brandão, Esmeralci Ferreira, Adriana S M Junqueira, José Firmino N Neto, Maria das Graças C Souza, Daniel Alexandre Bottino, Eliete Bouskela
Hypertension is associated with microcirculatory impairment. Our objectives were to evaluate endothelial function and inflammatory biomarkers in patients with resistant (RH) and mild to moderate (MMH) arterial hypertension in comparison to normotensives (control group-CG). Three groups, 25 patients each, have been investigated, by anamnesis, venous occlusion plethysmography (VOP) and serum determination of adhesion molecules (VCAM, ICAM), adiponectin, endothelin and C-reactive protein (CRP). Patients not using statins and with or without blood pressure control were also analyzed...
January 15, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29335333/predictors-of-in-hospital-death-after-aneurysmal-subarachnoid-hemorrhage-analysis-of-a-nationwide-database-swiss-sos-swiss-study-on-aneurysmal-subarachnoid-hemorrhage
#6
Martin Nikolaus Stienens, Menno Germans, Jan-Karl Burkhardt, Marian C Neidert, Christian Fung, David Bervini, Daniel Zumofen, Michel Röthlisberger, Serge Marbacher, Rodolfo Maduri, Thomas Robert, Martin A Seule, Philippe Bijlenga, Karl Schaller, Javier Fandino, Nicolas R Smoll, Nicolai Maldaner, Sina Finkenstädt, Giuseppe Esposito, Bawarjan Schatlo, Emanuela Keller, Oliver Bozinov, Luca Regli
BACKGROUND AND PURPOSE: To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage and to estimate their impact. METHODS: Retrospective analysis of prospective data from a nationwide multicenter registry on all aneurysmal subarachnoid hemorrhage cases admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009-2015). Both clinical and radiological independent predictors of in-hospital mortality were identified, and their effect size was determined by calculating adjusted odds ratios (aORs) using multivariate logistic regression...
January 15, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29327562/development-of-a-porcine-beating-heart-model-of-self-myocardial-retroperfusion-evaluation-of-hemodynamic-and-cardiac-responses-to-ischemia-and-clinical-applications
#7
Daniel Grandmougin, Jean-Mathieu Casse, Antoine Chalon, Yun Luo, Aude Falanga, Vanessa Marie, Fréderique Groubatch-Joineau, Brice Mourer, Marie Grandmougin, David Grandmougin, Guillaume Gauchotte, Juan-Pablo Maureira, Nguyen Tran
BACKGROUND: Retrograde perfusion into the coronary sinus is used to deliver cardioplegia. We developed an in-vivo porcine beating-heart model of self-myocardial retroperfusion (SMR) using the venous route to supply myocardial oxygenation and sought to assess hemodynamic and cardiac responses triggered by SMR before and after a prolonged occlusion of the LAD. METHODS: A bypass-line between the ascending aorta and the coronary sinus was made to perform a selective retrograde perfusion of the great cardiac vein with oxygenated blood (SMR)...
January 9, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29317081/hyperaccuracy-three-dimensional-reconstruction-is-able-to-maximize-the-efficacy-of-selective-clamping-during-robot-assisted-partial-nephrectomy-for-complex-renal-masses
#8
Francesco Porpiglia, Cristian Fiori, Enrico Checcucci, Daniele Amparore, Riccardo Bertolo
BACKGROUND: Available technologies could avoid global ischemia for the removal of a renal tumor. OBJECTIVE: To present hyperaccuracy three-dimensional (HA3D) reconstruction during robot-assisted partial nephrectomy (RAPN) and compare its efficacy in sponsoring successful selective clamping of renal arterial branches during RAPN. DESIGN, SETTING, AND PARTICIPANTS: Patients undergoing RAPN (January 2016-July 2017) for renal mass PADUA score ≥10 who underwent abdominal computed tomography scan with angiography...
January 6, 2018: European Urology
https://www.readbyqxmd.com/read/29316357/cerebrovascular-events-in-systemic-lupus-erythematosus
#9
John G Hanly, Qiuju Li, Li Su, Murray B Urowitz, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Ann E Clarke, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul Fortin, Dafna D Gladman, Ian N Bruce, Michelle Petri, Ellen M Ginzler, M A Dooley, Kristjan Steinsson, Rosalind Ramsey-Goldman, Asad A Zoma, Susan Manzi, Ola Nived, Andreas Jonsen, Munther A Khamashta, Graciela S Alarcón, Winn Chatham, Ronald F van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Manuel Ramos-Casals, S Sam Lim, Murat Inanc, Kenneth C Kalunian, Soren Jacobsen, Christine A Peschken, Diane L Kamen, Anca Askanase, Chris Theriault, Vernon Farewell
OBJECTIVE: To determine the frequency, associations and outcomes of cerebrovascular events (CerVEs) in a multi-ethnic/racial, prospective, SLE disease inception cohort. METHODS: Patients were assessed annually for 19 neuropsychiatric (NP) events including 5 types of CerVEs: (i) Stroke; (ii) Transient ischemia; (iii) Chronic multifocal ischemia; (iv) Subarachnoid/intracranial hemorrhage; (v) Sinus thrombosis. Global disease activity (SLEDAI-2K), SLICC/ACR damage index (SDI) and SF-36 scores were collected...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29315561/faim2-contributes-to-neuroprotection-by-erythropoietin-in-transient-brain-ischemia
#10
Daniel Komnig, Karen Gertz, Pardes Habib, Kay W Nolte, Tareq Meyer, Marc A Brockmann, Matthias Endres, Birgit Rathkolb, Martin Hrabě de Angelis, Jörg B Schulz, Björn H Falkenburger, Arno Reich
Delayed cell death in the penumbra region of acute ischemic stroke occurs through apoptotic mechanisms, making it amenable to therapeutic interventions. Fas/CD95 mediates apoptotic cell death in response to external stimuli. In mature neurons, Fas/CD95 signaling is modulated by Fas-apoptotic inhibitory molecule 2 (Faim2), which reduces cell death in animal models of stroke, meningitis, and Parkinson disease. Erythropoietin (EPO) has been studied as a therapeutic strategy in ischemic stroke. Erythropoietin stimulates the phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway, which regulates Faim2 expression...
January 8, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29313713/ischemic-and-bleeding-outcomes-after-coronary-artery-bypass-grafting-among-patients-initially-treated-with-a-p2y12-receptor-antagonist-for-acute-coronary-syndromes-insights-on-timing-of-discontinuation-of-ticagrelor-and-clopidogrel-prior-to-surgery
#11
Juan J Russo, Tyler E James, Marc Ruel, Jean-Yves Dupuis, Kuljit Singh, Daniel Goubran, Nikita Malhotra, Fraser Rubens, Aun-Yeong Chong, Benjamin Hibbert, Paul Boland, Diem Tt Tran, Jean-Francois Tanguay, Marie Lordkipanidzé, Louis Perrault, George A Wells, Michael Bourke, Vincent Chan, Derek Yf So
BACKGROUND: Clinical outcomes in acute coronary syndrome patients treated with P2Y12 inhibitors who require urgent coronary artery bypass grafting (CABG) have not been well studied. METHODS: We examined clinical outcomes in acute coronary syndrome patients in relation to the timing of CABG following P2Y12 inhibitor discontinuation (<72 h, 72 h to five days, >5 days). The primary ischemic outcome was a composite of death, reinfarction, need for revascularization, or stroke...
January 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29295526/inhibition-of-aquaporin-4-improves-the-outcome-of-ischaemic-stroke-and-modulates-brain-paravascular-drainage-pathways
#12
Ionica Pirici, Tudor Adrian Balsanu, Catalin Bogdan, Claudiu Margaritescu, Tamir Divan, Vacaras Vitalie, Laurentiu Mogoanta, Daniel Pirici, Roxana Octavia Carare, Dafin Fior Muresanu
Aquaporin-4 (AQP4) is the most abundant water channel in the brain, and its inhibition before inducing focal ischemia, using the AQP4 inhibitor TGN-020, has been showed to reduce oedema in imaging studies. Here, we aimed to evaluate, for the first time, the histopathological effects of a single dose of TGN-020 administered after the occlusion of the medial cerebral artery (MCAO). On a rat model of non-reperfusion ischemia, we have assessed vascular densities, albumin extravasation, gliosis, and apoptosis at 3 and 7 days after MCAO...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29288316/risk-factors-for-mortality-and-morbidity-in-elderly-patients-presenting-with-digestive-surgical-emergencies
#13
Hassen Hentati, Chady Salloum, Philippe Caillet, Eylon Lahat, Mara Disabato, Eric Levesque, Philippe Compagnon, Chetana Lim, Daniel Azoulay
BACKGROUND: Emergency digestive surgery is being increasingly performed in elderly patients. The aim of the present study was to identify the predictors of mortality and morbidity following emergency digestive surgery in patients aged 80 years and older. METHODS: A single-center retrospective review was performed of consecutive patients aged ≥65 years operated for a digestive surgical emergency between January 2011 and December 2013. Two groups were compared: group A (aged 65-79 years) and group B (aged ≥80 years)...
December 30, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29285808/is-prolonged-cold-ischemia-a-contraindication-to-using-kidneys-from-acute-kidney-injury-donors
#14
Giuseppe Orlando, Muhammad A Khan, Hany El-Hennawy, Alan C Farney, Jeffrey Rogers, Amber Reeves-Daniel, Michael D Gautreaux, William Doares, Scott Kaczmorski, Robert J Stratta
To determine the impact of prolonged cold ischemia time (CIT) on the outcome of acute kidney injury (AKI) renal grafts, we therefore performed a single center retrospective analysis in adult patients receiving kidney transplantation (KT) from AKI donors. Outcomes were stratified according to duration of CIT. 118 patients receiving AKI grafts were enrolled. Based on CIT, patients were stratified as follows: a) <20 hours, 27 patients; b) 20-30 hours, 52 patients; c) 30-40 hours, 30 patients; ≥40 hours, 9 patients...
December 28, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29284676/coordinated-regulation-of-intracellular-ph-by-two-glucose-sensing-pathways-in-yeast
#15
Daniel G Isom, Stephani C Page, Leonard B Collins, Nicholas J Kapolka, Geoffrey J Taghon, Henrik G Dohlman
The yeast Saccharomyces cerevisiae employs multiple pathways to coordinate sugar availability and metabolism. Glucose and other sugars are detected by a G protein coupled receptor, Gpr1, as well as a pair of transporter-like proteins, Rgt2 and Snf3. When glucose is limiting however, an ATP-driven proton pump (Pma1) is inactivated leading to a marked decrease in cytoplasmic pH. Here we determine the relative contribution of the two sugar sensing pathways to pH regulation. Whereas cytoplasmic pH is strongly dependent on glucose abundance, and is regulated by both glucose-sensing pathways, ATP is largely unaffected and therefore cannot account for the changes in Pma1 activity...
December 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29278540/a-case-of-fatal-cerebral-air-embolism-after-blunt-lung-trauma-postmortem-computed-tomography-and-autopsy-findings
#16
Isabella Mercurio, Daniele Capano, Riccardo Torre, Aldo Taddei, Gianmarco Troiano, Michele Scialpi, Mario Gabbrielli
Cerebral air embolism is caused by gas bubbles in the vascular system. These bubbles can cause cerebral ischemia by obstructing encephalic blood vessels. It is frequently associated with blunt and penetrating chest trauma as well as iatrogenic interventions. Lung trauma involving laceration of the respiratory tract, lung parenchyma, and blood vessels may result in direct communication of these structures, driving air or gas into the pulmonary venous system. We report a case of a blunt chest trauma that led to massive arterial air embolism that was possible to recognize with the help of postmortem computed tomographic scan examination...
December 22, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29276176/coronary-aneurysms-in-the-acute-patient-incidence-characterization-and-long-term-management-results
#17
Iván J Núñez-Gil, Belén Terol, Gisela Feltes, Luis Nombela-Franco, Pablo Salinas, Javier Escaned, Pilar Jiménez-Quevedo, Nieves Gonzalo, David Vivas, Daniel Bautista, Carlos Macaya, Antonio Fernández-Ortiz
BACKGROUND: Coronary aneurysms (1.5 times dilation the reference-vessel) are uncommon and have been diagnosed with increasing frequency with coronary angiography. The incidence varies from 1.5% to 5%. Reported complications are multiple: thrombosis, distal embolization, rupture and vasospasm, causing ischemia, heart failure or arrhythmias. However, the natural history and prognosis remains obscure. We aimed to describe the characteristics of acute patients with coronary aneurysms. METHODS: Prospective coronariography registry of patients with the diagnosis of coronary aneurysm between 2002 and 2013...
December 6, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29275960/inactivation-of-the-glucose-dependent-insulinotropic-polypeptide-receptor-improves-outcomes-following-experimental-myocardial-infarction
#18
John R Ussher, Jonathan E Campbell, Erin E Mulvihill, Laurie L Baggio, Holly E Bates, Brent A McLean, Keshav Gopal, Megan Capozzi, Bernardo Yusta, Xiemin Cao, Safina Ali, Minsuk Kim, M Golam Kabir, Yutaka Seino, Jinya Suzuki, Daniel J Drucker
Incretin hormones exert pleiotropic metabolic actions beyond the pancreas. Although the heart expresses both incretin receptors, the cardiac biology of GIP receptor (GIPR) action remains incompletely understood. Here we show that GIPR agonism did not impair the response to cardiac ischemia. In contrast, genetic elimination of the Gipr reduced myocardial infarction (MI)-induced ventricular injury and enhanced survival associated with reduced hormone sensitive lipase (HSL) phosphorylation; it also increased myocardial triacylglycerol (TAG) stores...
December 20, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29275946/ecg-predictors-of-cardiac-arrhythmias-in-older-adults-with-syncope
#19
Daniel K Nishijima, Amber L Lin, Robert E Weiss, Annick N Yagapen, Susan E Malveau, David H Adler, Aveh Bastani, Christopher W Baugh, Jeffrey M Caterino, Carol L Clark, Deborah B Diercks, Judd E Hollander, Bret A Nicks, Manish N Shah, Kirk A Stiffler, Alan B Storrow, Scott T Wilber, Benjamin C Sun
STUDY OBJECTIVE: Cardiac arrhythmia is a life-threatening condition in older adults who present to the emergency department (ED) with syncope. Previous work suggests the initial ED ECG can predict arrhythmia risk; however, specific ECG predictors have been variably specified. Our objective is to identify specific ECG abnormalities predictive of 30-day serious cardiac arrhythmias in older adults presenting to the ED with syncope. METHODS: We conducted a prospective, observational study at 11 EDs in adults aged 60 years or older who presented with syncope or near syncope...
December 21, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29274187/sex-differences-in-diagnoses-treatment-and-outcomes-for-emergency-department-patients-with-chest-pain-and-elevated-cardiac-troponin
#20
Karin H Humphries, May K Lee, Mona Izadnegahdar, Min Gao, Daniel T Holmes, Frank X Scheuermeyer, Martha Mackay, Andre Mattman, Eric Grafstein
OBJECTIVE: While sex differences in the treatment and outcomes of subjects with acute coronary syndromes are well documented, little is known about the impact of cardiac troponin (cTn) levels obtained in the emergency department (ED) on the observed sex differences. We sought to determine whether cTn levels by chest pain features modify sex differences in diagnosis, treatment and outcomes in patients presenting with chest pain suggestive of ischemia. METHODS: All adults presenting to two hospitals in Vancouver, Canada between May 2008 and Mar 2013 with ischemic chest pain and with cTn testing were included in the study...
December 23, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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