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Wound healing diabetes

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https://www.readbyqxmd.com/read/28730726/changes-in-the-extracellular-matrix-surrounding-human-chronic-wounds-revealed-by-2-photon-imaging
#1
Jessica E S Sutcliffe, Christopher Thrasivoulou, Thomas E Serena, Leigh Madden, Toby Richards, Anthony R J Phillips, David L Becker
Chronic wounds are a growing problem worldwide with no effective therapeutic treatments available. Our objective was to understand the composition of the dermal tissue surrounding venous leg ulcers and diabetic foot ulcers (DFU). We used novel 2-photon imaging techniques alongside classical histology to examine biopsies from the edges of two common types of chronic wound, venous leg ulcers and DFU. Compared to normal intact skin, we found that collagen levels are significantly reduced throughout the dermis of venous leg ulcer biopsies and DFU, with a reduction in both fibril thickness and abundance...
July 20, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28729818/a-cooperative-copper-metal-organic-framework-hydrogel-system-improves-wound-healing-in-diabetes
#2
Jisheng Xiao, Siyu Chen, Ji Yi, Hao Zhang, Guillermo A Ameer
Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown promise in wound healing applications possibly by promoting angiogenesis. However, reported treatments that use copper ions require multiple applications of copper salts or oxides to the wound bed, exposing the patient to potentially toxic levels of copper ions and resulting in variable outcomes...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28729536/weakened-il-15-production-and-impaired-mtor-activation-alter-dendritic-epidermal-t-cell-homeostasis-in-diabetic-mice
#3
Zhongyang Liu, Guangping Liang, Li Gui, Yashu Li, Meixi Liu, Yang Bai, Xiaorong Zhang, Xiaohong Hu, Jian Chen, Chibing Huang, Xusheng Liu, Gaoxing Luo, Jun Wu, Weifeng He
Diabetes is associated with impaired wound healing, which may be caused primarily by a deficiency in dendritic epidermal T cells (DETCs). In the epidermis, IL-15, IGF-1, and mTOR are known to regulate the maintenance of DETCs; however, it is unclear how these molecules may intersect to regulate DETC homeostasis in diabetes. Here, we show that the reduction of DETCs in the epidermis of diabetic mice is caused by altered homeostasis mediated by a reduction in IL-15 levels. Both impaired mTOR activation and reduction of IL-15 in the epidermis play important roles in DETC homeostasis...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727481/leucocyte-and-platelet-rich-fibrin-l-prf-as-a-regenerative-medicine-strategy-for-the-treatment-of-refractory-leg-ulcers-a-prospective-cohort-study
#4
Nelson R Pinto, Matias Ubilla, Yelka Zamora, Verónica Del Rio, David M Dohan Ehrenfest, Marc Quirynen
Chronic wounds (VLU: venous leg ulcer, DFU: diabetic foot ulcer, PU: pressure ulcer, or complex wounds) affect a significant proportion of the population. Despite appropriate standard wound care, such ulcers unfortunately may remain open for months or even years. The use of leukocyte- and platelet-rich fibrin (L-PRF) to cure skin ulcers is a simple and inexpensive method, widely used in some countries but unknown or neglected in most others. This auto-controlled prospective cohort study explored and quantified accurately for the first time the adjunctive benefits of topical applications of L-PRF in the management of such refractory ulcers in a diverse group of patients...
July 20, 2017: Platelets
https://www.readbyqxmd.com/read/28720320/hydrogen-sulfide-improves-diabetic-wound-healing-in-ob-ob-mice-via-attenuating-inflammation
#5
Huichen Zhao, Shengxia Lu, Jiachao Chai, Yuchao Zhang, Xiaoli Ma, Jicui Chen, Qingbo Guan, Meiyan Wan, Yuantao Liu
BACKGROUND: The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H2S) has been reported to have multiple biological activities. We aim to investigate the role of H2S in impaired wound healing in ob/ob mice and explore the possible mechanisms involved. PROCEDURES: Full-thickness skin dorsal wounds were created on ob/ob mice and C57BL/6 mice. Cystathionine-γ-lyase (CSE) expression and H2S production were determined in granulation tissues of the wounds...
June 30, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28716357/clinical-and-metabolic-response-to-flaxseed-oil-omega-3-fatty-acids-supplementation-in-patients-with-diabetic-foot-ulcer-a-randomized-double-blind-placebo-controlled-trial
#6
Zahra Soleimani, Fatemeh Hashemdokht, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
BACKGROUND: Data on the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU) are scarce. OBJECTIVE: This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with DFU. METHODS: The current randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85years old) with grade 3 DFU...
June 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28713016/a-conducive-bioceramic-polymer-composite-biomaterial-for-diabetic-wound-healing
#7
Fang Lv, Jie Wang, Peng Xu, Yiming Han, Hongshi Ma, He Xu, Shijie Chen, Jiang Chang, Qinfei Ke, Mingyao Liu, Zhengfang Yi, Chengtie Wu
Diabetic wound is a common complication of diabetes. Biomaterials offer great promise in inducing tissue regeneration for chronic wound healing. Herein, we reported a conducive Poly (caprolactone) (PCL)/gelatin nanofibrous composite scaffold containing silicate-based bioceramic particles (Nagelschmidtite, NAGEL, Ca7P2Si2O16) for diabetic wound healing. NAGEL bioceramic particles were well distributed in the inner of PCL/gelatin nanofibers via co-electrospinning process and the Si ions maintained a sustained release from the composite scaffolds during the degradation process...
July 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28712679/the-molecular-biology-in-wound-healing-non-healing-wound
#8
REVIEW
Chun Qing
The development of molecular biology and other new biotechnologies helps us to recognize the wound healing and non-healing wound of skin in the past 30 years. This review mainly focuses on the molecular biology of many cytokines (including growth factors) and other molecular factors such as extracellular matrix (ECM) on wound healing. The molecular biology in cell movement such as epidermal cells in wound healing was also discussed. Moreover many common chronic wounds such as pressure ulcers, leg ulcers, diabetic foot wounds, venous stasis ulcers, etc...
June 30, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28707412/differences-in-the-daily-activity-of-patients-with-diabetic-foot-ulcers-compared-to-controls-in-their-free-living-environments
#9
Helen Sheahan, Kimberley Canning, Nishka Refausse, Ewan M Kinnear, Greg Jorgensen, James R Walsh, Peter A Lazzarini
The aims of our study were to investigate multiple daily activity outcomes in patients with diabetic foot ulcers (DFU) compared to diabetic peripheral neuropathy (DPN) and diabetes (DM) controls in their free-living environments. We examined daily activity outcomes of 30 patients with DFU, 23 DPN and 20 DM. All patients wore a validated multi-sensor device for > 5 days (>22 hours per day) to measure their daily activity outcomes: steps, energy expenditure (kJ), average metabolic equivalent tasks (METs), physical activity (>3·0 METs) duration and energy expenditure, lying duration, sleep duration and sleep quality...
July 13, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28704592/erratum-human-wharton-s-jelly-stem-cells-and-its-conditioned-medium-enhance-healing-of-excisional-and-diabetic-wounds
#10
Chui-Yee Fong, Kimberley Tam, Suganya Cheyyatraivendran, Shu-Uin Gan, Kalamegam Gauthaman, Arunmozhiarasi, Kandiah Jeyaseelan, Mahesh Choolani, Arijt Biswas, Ariff Bongso
No abstract text is available yet for this article.
September 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28704171/a-bioluminescent-pseudomonas-aeruginosa-wound-model-reveals-increased-mortality-of-type-1-diabetic-mice-to-biofilm-infection
#11
Agostinho Hunt A M, Gibson J A, Larrivee C L, O'Reilly S, Navitskaya S, Needle D B, Abramovitch R B, Busik J V, Waters C M
OBJECTIVE: To examine how bacterial biofilms, as contributing factors in the delayed closure of chronic wounds in patients with diabetes, affect the healing process. METHOD: We used daily microscopic imaging and the IVIS Spectrum in vivo imaging system to monitor biofilm infections of bioluminescent Pseudomonas aeruginosa and evaluate healing in non-diabetic and streptozotocin-induced diabetic mice. RESULTS: Our studies determined that diabetes alone did not affect the rate of healing of full-depth murine back wounds compared with non-diabetic mice...
July 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28704149/amputation-predictors-in-diabetic-foot-ulcers-treated-with-hyperbaric-oxygen
#12
S T Kaplan, D Hemsinli, S Kaplan, A Arslan
OBJECTIVE: Although hyperbaric oxygen therapy (HBOT) has long been used for diabetic foot ulcers (DFUs), its effectiveness is still controversial. The aim of this study was to investigate the efficacy of HBOT in the management of DFUs and identify amputation predictors. METHOD: Patients with chronic DFUs (Wanger grade 2-5) were included in the study, which took place between January 2010 and December 2012. HBOT, 100% oxygen, 2.4 atmosphere absolute (ATA) for 120 minutes, was administered to all patients in addition to standard treatment...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28700064/clinical-and-epidemiological-aspects-of-cases-of-tuberculosis-associated-with-diabetes-in-salvador-bahia-brazil
#13
Sâmia Barreto Leal, Gleide Santos de Araújo, Joilda Silva Nery, Carlos Antonio de Souza Teles Santos, Maeli Gomes de Oliveira, Mauricio Lima Barreto, Susan Martins Pereira
INTRODUCTION: This study compares the clinical and epidemiological features of patients with TB, with and without DM. METHODS: New cases of active pulmonary TB that occurred in Salvador, Bahia, Brazil between 2008 and 2010 were included. DM was diagnosed by based on diagnostic criteria established by the American Diabetes Association. RESULT: S: Of the 323 cases of TB, 44 (13.6%) were diabetic . Patients with TB and DM were older (44.7%), with a high level of education (34...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28699352/redox-signaling-in-diabetic-wound-healing-regulates-extracellular-matrix-deposition
#14
Britta Kunkemoeller, Themis Kyriakides
SIGNIFICANCE: Impaired wound healing is a major complication of diabetes, and can lead to development of chronic foot ulcers in a significant portion of patient. Despite the danger posed by poor healing, very few specific therapies exist, leaving patients at risk of hospitalization, amputation, and further decline in overall health. Recent Advances: Redox signaling is a key regulator of wound healing, especially through its influence on the extracellular matrix (ECM). Normal redox signaling is disrupted in diabetes leading to several pathological mechanisms that alter the balance between reactive oxygen species (ROS) generation and scavenging...
July 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28698384/palmitic-acid-dysregulates-the-hippo-yap-pathway-and-inhibits-angiogenesis-by-inducing-mitochondrial-damage-and-activating-the-cytosolic-dna-sensor-cgas-sting-irf3-signaling
#15
Liangshuai Yuan, Yun Mao, Wei Luo, Weiwei Wu, Hao Xu, Xing Li Wang, Ying H Shen
Impaired angiogenesis and wound healing carry significant morbidity and mortality in diabetic patients. Metabolic stress from hyperglycemia and elevated free fatty acids have been shown to inhibit endothelial angiogenesis. However, the underlying mechanisms remain poorly understood. In this study, we show that dysregulation of the Hippo-YAP pathway, an important signaling in regulating tissue repair and regeneration, underlies palmitic acid (PA) -induced inhibition of endothelial angiogenesis. PA inhibited endothelial cell proliferation, migration and tube formation, which were associated with increased MST1 expression, YAP phosphorylation/inactivation and nuclear exclusion...
July 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28697694/midterm-outcomes-from-a-pilot-study-of-percutaneous-deep-vein-arterialization-for-the-treatment-of-no-option-critical-limb-ischemia
#16
Steven Kum, Yih Kai Tan, Michiel A Schreve, Roberto Ferraresi, Ramon L Varcoe, Andrej Schmidt, Dierk Scheinert, Jihad A Mustapha, Darryl M Lim, Derek Ho, Tjun Y Tang, Vlad-Adrian Alexandrescu, Pramook Mutirangura
PURPOSE: To report the initial clinical experience with percutaneous deep vein arterialization (PDVA) to treat critical limb ischemia (CLI) via the creation of an arteriovenous fistula. METHODS: Seven patients (median age 85 years; 5 women) with CLI and no traditional endovascular or surgical revascularization options (no-option CLI) were recruited in a pilot study to determine the safety of PDVA. All patients were diabetic; 4 had Rutherford category 6 ischemia...
July 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28697404/il-33-improves-wound-healing-through-enhanced-m2-macrophage-polarization-in-diabetic-mice
#17
Rongguo He, Hui Yin, Baohong Yuan, Tao Liu, Li Luo, Ping Huang, Liangcheng Dai, Kang Zeng
IL-33 is a newly discovered member of the IL-1 family and has been identified as a potent inducer of Th2 type immunity. Emerging evidence imply that IL-33 may also act as an alarm to alert the immune system when released by epithelial barrier tissues during trauma or infection. In this study, we further investigate the potential efficacy of IL-33 on dermal wound healing in streptozotocin-induced diabetic mice. A full-thickness skin wound was generated on the back of diabetic mice and treated with IL-33 or vehicle topically...
July 8, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28696493/total-contact-cast-system-to-heal-diabetic-foot-ulcers
#18
Brock Liden
Off-loadinga diabetic foot ulcer is a cornerstone of quality wound care for diabetic patients to allow cellular growth in the wound bed. While total contact casts (TCC) have been described as the gold standard for off-loading the wound, the complexity of application and the time commitment for both application and drying have discouraged health professionals from using them. This retrospective case series, conducted in a podiatric practice, evaluated using a TCC system that helps address the three components in which guidelines should be addressed when caring for a diabetic foot: V - vascular management, I - infection management and prevention, and P - pressure relief...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28692083/using-biomaterials-to-rewire-the-process-of-wound-repair
#19
REVIEW
Anna Stejskalová, Benjamin D Almquist
Wound healing is one of the most complex processes that our bodies must perform. While our ability to repair wounds is often taken for granted, conditions such as diabetes, obesity, or simply old age can significantly impair this process. With the incidence of all three predicted to continue growing into the foreseeable future, there is an increasing push to develop strategies that facilitate healing. Biomaterials are an attractive approach for modulating all aspects of repair, and have the potential to steer the healing process towards regeneration...
July 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28688286/co-delivery-of-a-growth-factor-and-a-tissue-protective-molecule-using-elastin-biopolymers-accelerates-wound-healing-in-diabetic-mice
#20
Julie Devalliere, Kevin Dooley, Yong Yu, Sarah S Kelangi, Basak E Uygun, Martin L Yarmush
Growth factor therapy is a promising approach for chronic diabetic wounds, but strategies to efficiently and cost-effectively deliver active molecules to the highly proteolytic wound environment remain as major obstacles. Here, we re-engineered keratinocyte growth factor (KGF) and the cellular protective peptide ARA290 into a protein polymer suspension with the purpose of increasing their proteolytic resistance, thus their activity in vivo. KGF and ARA290 were fused with elastin-like peptide (ELP), a protein polymer derived from tropoelastin, that confers the ability to separate into a colloidal suspension of liquid-like coacervates...
June 30, 2017: Biomaterials
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