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Radiation therapy for small lymphocytic lymphoma

Thomas Gryc, Florian Putz, Nicole Goerig, Sonia Ziegler, Rainer Fietkau, Luitpold V Distel, Barbara Schuster
INTRODUCTION: Idelalisib is approved for the treatment of relapsed chronic lymphocytic leukemia together with Rituximab and for monotherapy of follicular B-cell non-Hodgkin's lymphoma and small lymphocytic lymphoma. It is a potent and selective phosphatidylinositol 3-kinase-δ (PI3K-δ) inhibitor. PI3K-δ primarily is expressed in B-cells and prevents effectively proliferation in malignant B-cells. METHODS: We provide a detailed report on treatment history and photo documentation of acute adverse effects of radiation therapy with simultaneous Idelalisib medication in one case of B-CLL...
June 28, 2017: Radiation Oncology
Tomoko Uchiyama, Hirokazu Nakamine, Kohei Morita, Hiroe Itami, Tokiko Nakai, Masato Takano, Maiko Takeda, Kinta Hatakeyama, Junko Takahama, Yasuhito Tanase, Hiroshi Kobayashi, Chiho Ohbayashi
We report an incidental case of intravascular large B-cell lymphoma (IVLBCL) coexisting with an ovarian carcinoma in a 76-year-old woman. She visited our hospital with difficulty in defecation. Magnetic resonance imaging and computerized tomography scan revealed a solid and cystic mass probably arising from the left ovary. Gross examination of the tumor obtained by an exploratory surgery showed a solid area in a simple cyst. The ovarian tumor was diagnosed as a high-grade serous carcinoma (HGSC). Early in the post-operative course, this patient developed fever of unknown origin with central nervous system manifestations...
2016: Journal of Clinical and Experimental Hematopathology: JCEH
Vishwas Parekh, Eun-Hee Shim, Charles F Knapp, Lauren Hughey, Craig A Elmets, Kristopher McKay
T lymphocytes belong to 2 distinct sublineages that express either αβ or γδ T-cell receptor (TCR) complex. Although malignancy is a great instigator of lineage infidelity, as exemplified by aberrant expression of numerous lineage markers in lymphoma cells, malignant T cells rarely coexpress αβ and γδ TCR complexes. Similarly, only rare cases of CD4/CD8 double-positive primary cutaneous T-cell lymphoma have been reported. In this report, we describe a remarkable case of primary cutaneous T-cell lymphoma coexpressing αβ and γδ TCR complexes, strong diffuse CD8, and a very restricted coexpression of CD4 and CD8...
January 2016: American Journal of Dermatopathology
Taichi Nakamura, Tetsuhide Ito, Yasunobu Abe, Kensaku Izutsu, Junya Gibo, Souichi Itaba, Ken Kawabe, Takamasa Oono, Hisato Igarashi, Koji Yamaguchi, Kouichi Ohshima, Ryoichi Takayanagi
The case concerns a 55-year-old Japanese man with multiple pancreatic tumors that were incidentally detected by ultrasonography (US) in a routine medical examination. He consulted a doctor since either neuroendocrine tumors or metastases of small-cell lung carcinoma were suspected, because he had an abnormal shadow in the lung. Then he was transferred to our hospital. Imaging studies showed multiple pancreatic tumors of 3.0-cm diameter in the head, 1.0 cm in the body and 1.5 cm in the tail, respectively. Specimen by endoscopic ultrasonography fine-needle aspiration cytology (EUS-FNAC) revealed numerous B-cell lymphocytes, but a definite diagnosis of malignant lymphoma could not be obtained...
December 2008: Clinical Journal of Gastroenterology
Martin T King, Sarah S Donaldson, Michael P Link, Yasodha Natkunam, Ranjana H Advani, Richard T Hoppe
PURPOSE: To analyze treatment outcomes for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) at a single institution. PATIENTS AND METHODS: Patients with newly diagnosed NLPHL between 1996 and 2013 were reviewed retrospectively. Patients treated before 1996 were excluded because the majority received extended field radiation therapy (RT) alone. RESULTS: Fifty-five patients (22 ≤ 21 years old) were identified. The median follow-up time was 6...
May 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Steven Hobson, Terence McGarry, Anatoly Leytin
Cancer Student/Resident Case Report Posters ISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Primary intrapulmonary thymomas are rare ectopic thymic epithelial neoplasms with 32 cases reported to date1. Tumors are identified and characterized with various imaging modalities, whereas microscopic morphology and immunohistochemistry provide diagnosis and staging. Treatment involves surgical excision and, if indicated, adjuvant radiation therapy...
October 1, 2014: Chest
Shi Wang, L Jeffrey Medeiros, Zijun Y Xu-Monette, Shanxiang Zhang, Dennis P O'Malley, Attilio Orazi, Zhuang Zuo, Carlos E Bueso-Ramos, Cameron C Yin, Zhiyu Liu, Roberto N Miranda, Ken H Young
Hodgkin lymphoma (HL) is classified into 2 largely distinct subgroups, namely nodular lymphocyte predominant HL (NLPHL) and classic HL (CHL). CHL is further divided into nodular sclerosis, lymphocyte-rich, mixed cellularity (MCCHL) and lymphocyte-depleted (LDCHL) subtypes. In industrialized nations, Epstein-Barr virus (EBV) has been associated with all types of CHL, especially the MCCHL and LDCHL subtypes, but is rare in NLPHL. We report 8 cases of EBV-positive NLPHL occurring in patients in the United States...
August 2014: Annals of Diagnostic Pathology
Ling Zhang, Haipeng Shao
Primary cutaneous CD4 positive small/medium pleomorphic T-cell lymphoma (SMPTCL) represents a provisional subtype of primary cutaneous T-cell lymphoma with indolent clinical course. A few aggressive fatal cases with increased proliferation rate and few infiltrating CD8 positive T-cells have been reported. We describe a case of SMPTCL with an increased proliferation rate, admixed CD30-positive large lymphoid cells, and few infiltrating CD8 positive T-cells. The lymphoma cells were positive for CD3, CD4, CD2 and CD5, and negative for CD8...
August 2013: Journal of Cutaneous Pathology
Andrea L Russo, Yu-Hui Chen, Neil E Martin, Anant Vinjamoori, Sarah K Luthy, Arnold Freedman, Evan M Michaelson, Barbara Silver, Peter M Mauch, Andrea K Ng
PURPOSE: To investigate clinical and pathologic factors significant in predicting local response and time to further treatment after low-dose involved-field radiation therapy (LD-IFRT) for non-Hodgkin lymphoma (NHL). METHODS AND MATERIALS: Records of NHL patients treated at a single institution between April 2004 and September 2011 were retrospectively reviewed. Low-dose involved-field radiation therapy was given as 4 Gy in 2 fractions over 2 consecutive days. Treatment response and disease control were determined by radiographic studies and/or physical examination...
May 1, 2013: International Journal of Radiation Oncology, Biology, Physics
Katharine H Xing, Kerry J Savage
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) represents 5% of all Hodgkin lymphoma and has distinct clinico-pathological features. It is typified by the presence of lymphocyte predominant cells, which are CD20(+) , CD15(-) and CD30(-) and are found scattered amongst small B-lymphocytes arranged in a nodular pattern. Patients typically are males presenting with localized, peripheral lymphadenopathy. Despite frequent and often late or multiple relapses the prognosis is favourable. Deaths due to NLPHL are uncommon, but secondary malignancies and other treatment toxicities contribute appreciably to overall mortality...
May 2013: British Journal of Haematology
(no author information available yet)
OBJECTIVE: To assess the effectiveness, safety and cost-effectiveness of extracorporeal photophoresis (ECP) for the treatment of refractory erythrodermic cutaneous T cell lymphoma (CTCL) and refractory chronic graft versus host disease (cGvHD). BACKGROUND: CUTANEOUS T CELL LYMPHOMA: Cutaneous T cell lymphoma (CTCL) is a general name for a group of skin affecting disorders caused by malignant white blood cells (T lymphocytes). Cutaneous T cell lymphoma is relatively uncommon and represents slightly more than 2% of all lymphomas in the United States...
2006: Ontario Health Technology Assessment Series
Victoria L Williams, Carlos A Torres-Cabala, Madeleine Duvic
BACKGROUND AND OBJECTIVE: Primary cutaneous small- to medium-sized CD4+ pleomorphic T-cell lymphoma (PCSM-TCL) is a rare and provisional subcategory of cutaneous T-cell lymphoma, associated with a favorable prognosis. We present five cases of PCSM-TCL and review the literature to address questions surrounding its diagnosis and treatment. METHODS: A retrospective review was conducted of 353 patients with non-mycosis fungoides cutaneous lymphomas evaluated at the M...
December 1, 2011: American Journal of Clinical Dermatology
Sydney X Lu, Lucy W Kappel, Anne-Marie Charbonneau-Allard, Renée Atallah, Amanda M Holland, Claire Turbide, Vanessa M Hubbard, Jimmy A Rotolo, Marsinay Smith, David Suh, Christopher King, Uttam K Rao, Nury Yim, Johanne L Bautista, Robert R Jenq, Olaf Penack, Il-Kang Na, Chen Liu, George Murphy, Onder Alpdogan, Richard S Blumberg, Fernando Macian, Kathryn V Holmes, Nicole Beauchemin, Marcel R M van den Brink
BACKGROUND: Allogeneic bone marrow transplantation (allo-BMT) is a potentially curative therapy for a variety of hematologic diseases, but benefits, including graft-versus-tumor (GVT) activity are limited by graft-versus-host-disease (GVHD). Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors. It regulates a variety of physiologic and pathological processes such as tumor biology, leukocyte activation, and energy homeostasis...
2011: PloS One
Han-Shui Hsu, Pin-I Huang, Yuh-Lih Chang, Ching Tzao, Yi-Wei Chen, Hsin-Chin Shih, Shih-Chieh Hung, Yu-Chih Chen, Ling-Ming Tseng, Shih-Hwa Chiou
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) signaling reportedly promotes tumor malignancy and recurrence in nonsmall cell lung cancer (NSCLC). It was demonstrated previously that the STAT3 pathway maintains the tumorigenicity and therapeutic resistance of malignant tumors as well as cancer stem cells (CSCs). The objective of the current study was to investigate the effect of the strong STAT3 inhibitor, cucurbitacin I, in prominin-1 (CD133)-positive lung cancer cells...
July 1, 2011: Cancer
Philip Saunders, Adam Cisterne, Jocelyn Weiss, Kenneth F Bradstock, Linda J Bendall
BACKGROUND: Despite incremental improvements in outcomes for patients with acute lymphoblastic leukemia, significant numbers of patients still die from this disease. Mammalian target of rapamycin inhibitors have shown potential in vitro and in vivo as therapeutic agents against a range of tumors including acute lymphoblastic leukemia. DESIGN AND METHODS: Flow cytometry was used to evaluate drug-induced cell death in acute lymphoblastic leukemia cell lines and patients' samples...
January 2011: Haematologica
Puneeth Iyengar, Ali Mazloom, Ferial Shihadeh, Ghina Berjawi, Bouthaina Dabaja
BACKGROUND: Most Hodgkin lymphoma (HL) patients present with disease in nodal regions. However, in a small subset, disease develops in unique anatomic sites such as the head and neck area. This study aims to identify the characteristics and outcomes of patients who develop HL involving extranodal and nodal head and neck sites. METHODS: The authors searched The University of Texas M. D. Anderson Cancer Center's database for HL patients treated between 1967 and 2007 and included those with HL at head and neck sites...
August 15, 2010: Cancer
Ali Tavallali, Carol L Shields, Carlos Bianciotto, Jerry A Shields
PURPOSE: To report a patient with presumed nonarteritic anterior ischemic optic neuropathy (NAION) found on our evaluation to have bilateral uveal lymphoma. METHODS: The clinical history and physical examination, Humphrey visual field testing, ultrasonography, magnetic resonance imaging (MRI), and fine needle aspiration biopsy specimen of a 60-year-old man with presumed NAION were evaluated. RESULTS: The patient initially presented with painless blurred vision OD and foreign body sensation OS...
September 2010: European Journal of Ophthalmology
Karen L Grogg, Sungmi Jung, Lori A Erickson, Rebecca F McClure, Ahmet Dogan
Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, a provisional entity in the 2005 WHO-EORTC classification for cutaneous lymphomas, is not well characterized. Fifteen cases meeting the definition of this entity were identified. Fourteen represented solitary lesions on the head/neck (n=9), upper extremity (n=4), or trunk (n=1). One patient presented with multiple lesions on the trunk and extremities. Histologically, the infiltrate showed a nodular pattern in the dermis and subcutis without epidermotropism, and had a polymorphous composition with a predominance of small to medium-sized CD4-positive T cells...
June 2008: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Sheila N J Sait, Melinda A Claydon, Jeffrey M Conroy, Norma J Nowak, Maurice Barcos, Maria R Baer
Reciprocal chromosomal translocations involving the MLL gene at chromosome region 11q23 are recurring cytogenetic abnormalities in both de novo and therapy-related acute myeloid leukemia (AML) and in acute lymphoblastic leukemia. We report a t(4;11)(p12;q23) with rearrangement of MLL and FRYL (also known as AF4p12), a human homolog to the furry gene of Drosophila, in an adult patient with therapy-related AML after fludarabine and rituximab therapy for small lymphocytic lymphoma and radiation therapy for breast carcinoma...
September 2007: Cancer Genetics and Cytogenetics
Masato Saka, Jun Morioka, Koji Kajiwara, Koichi Yoshikawa, Takayuki Amano, Hisashi Kubota, Sadahiro Nomura, Syoichi Kato, Masami Fujii, Hirosuke Fujisawa, Michiyasu Suzuki
A 72-year-old female presented with a lump in the left superior-lateral eyelid. The magnetic resonance imaging showed a well-delineated mass in the left lacrimal gland. The tumor was isointense on both the T1 and T2 weighted images, and it was homogenously enhanced with Gd-DTPA. Surgery via the trans-cranial approach revealed a pinkish and elastic-hard tumor. Total resection was successfully performed. The hematoxilyn-eosin staining of the surgical specimen showed a dense infiltrate of lymphocytes, which were composed predominantly of small lymphocytes, centrocyte-like cells, monocytoid cells, and occasionally transformed lymphocytes...
May 2007: No Shinkei Geka. Neurological Surgery
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