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https://www.readbyqxmd.com/read/28425920/development-of-a-fast-monte-carlo-dose-calculation-system-for-online-adaptive-radiation-therapy-quality-assurance
#1
Yuhe Wang, Thomas Mazur, Justin Park, Deshan Yang, Sasa Mutic, H Harold Li
Online adaptive radiation therapy (ART) based on real-time magnetic resonance imaging represents a paradigm-changing treatment scheme. However, conventional quality assurance (QA) methods based on phantom measurements are not feasible with the patient on the treatment couch. The purpose of this work is to develop a fast Monte Carlo system for validating online re-optimized tri-60Co IMRT adaptive plans with both high accuracy and speed. The Monte Carlo system is based on Dose Planning Method (DPM) code with further simplification of electron transport and consideration of external magnetic fields...
April 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28415388/targeted-delivery-of-docetaxel-via-pi-pi-stacking-stabilized-dendritic-polymeric-micelles-for-enhanced-therapy-of-liver-cancer
#2
Xiaolong Tang, Shuping Zhou, Xinrong Tao, Jian Wang, Fangyu Wang, Yong Liang
Delivery of taxane-based chemotherapeutics including Docetaxel (DTX) by conventional polymeric micelles still suffers from insufficient stability and rapid premature release during the circulation, which limits their targeting and anticancer efficiency. To conquer these challenges, we developed a novel DTX-loaded Pi-Pi stacking-stabilized dendritic polymeric micelle for targeted therapy of liver cancer. This dendritic polymeric micelle, referred to DPM-DTX-cRGD, was self-assembled from DTX and biodegradable dendritic block copolymers Poly(amidoamine)-poly(γ-benzyl-l-Glutamate)-b-polyethylene glycol-cRGD (PAM-PBLG-b-PEG-cRGD)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28409073/facial-paralysis-and-hearing-loss-a-rare-manifestation-of-prostate-cancer-metastases
#3
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Muhammad R Raza, Nikhil Nalluri, Frank Forte
Dural prostate metastases (DPM) are a rare manifestation of metastatic prostate cancer seen in approximately one to six percent of cases. Presenting symptoms may include signs of elevated intracranial pressure, headache, altered mental status, or cranial nerve palsies. Hearing loss, sensory changes, dysarthria, and dysphagia are rare symptoms in DPM that were present in our patient. We present a case of a 58-year-old male with a known diagnosis of adenocarcinoma of the prostate presenting with symptoms of acute exacerbation of chronic obstructive pulmonary disease (COPD), sub-acute right-sided hearing loss, and right-sided facial paralysis...
March 3, 2017: Curēus
https://www.readbyqxmd.com/read/28400239/efficient-synthesis-of-a-multi-substituted-diphenylmethane-skeleton-as-a-steroid-mimetic
#4
Takashi Misawa, Katsuya Tanaka, Yosuke Demizu, Masaaki Kurihara
Steroids are important components of cell membranes and are involved in several physiological functions. A diphenylmethane (DPM) skeleton has recently been suggested to act as a mimetic of the steroid skeleton. However, difficulties are associated with efficiently introducing different substituents between two phenyl rings of the DPM skeleton, and, thus, further structural development based on the DPM skeleton has been limited. We herein developed an efficient synthetic method for introducing different substituents into two phenyl rings of the DPM skeleton...
March 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28400188/devascularized-parenchymal-mass-associated-with-partial-nephrectomy-predictive-factors-and-impact-on-functional-recovery
#5
Wen Dong, Jitao Wu, Chalairat Suk-Ouichai, Elvis Caraballo Antonio, Erick Remer, Jianbo Li, Joseph Zabell, Sudhir Isharwal, Steven C Campbell
PURPOSE: Parenchymal mass loss is the predominant factor associated with functional outcomes after partial nephrectomy (PN), and is primarily due to excised parenchymal mass (EPM) and/or devascularized parenchymal mass (DPM). We evaluate the importance of EPM and DPM relative to functional recovery after PN. MATERIALS AND METHODS: 168 PN patients had necessary studies to determine EPM and DPM and evaluate parenchymal mass changes and functional loss within the operated kidney...
April 8, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28381304/evaluation-of-biosecurity-measures-to-prevent-indirect-transmission-of-porcine-epidemic-diarrhea-virus
#6
Yonghyan Kim, My Yang, Sagar M Goyal, Maxim C-J Cheeran, Montserrat Torremorell
BACKGROUND: The effectiveness of biosecurity methods to mitigate the transmission of porcine epidemic diarrhea virus (PEDV) via farm personnel or contaminated fomites is poorly understood. This study was undertaken to evaluate the effectiveness of biosecurity procedures directed at minimizing transmission via personnel following different biosecurity protocols using a controlled experimental setting. RESULTS: PEDV RNA was detected from rectal swabs of experimentally infected (INF) and sentinel pigs by real-time reverse transcription polymerase chain reaction (rRT-PCR)...
April 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28346827/effects-of-cerium-oxide-and-ferrocene-nanoparticles-addition-as-fuel-borne-catalysts-on-diesel-engine-particulate-emissions-environmental-and-health-implications
#7
Zhi-Hui Zhang, Rajasekhar Balasubramanian
This study systematically examined the potential impacts of doping CeO2 and Fe(C5H5)2 nanoparticles as fuel-borne catalysts (FBCs) to ultralow sulfur diesel (ULSD) fuel on the physical, chemical and toxicological characteristics of diesel particulate matter (DPM). The FBCs-doped fuels are effective in promoting soot oxidation and reducing the DPM mass emissions, but lead to a significant increase in the total particle counts due to the formation of self-nucleated metallic nanoparticles. Compared to undoped ULSD, the FBCs-doped fuels result in higher concentrations of particle-phase polycyclic aromatic hydrocarbons (PAHs) and n-alkanes, higher fractions of organic carbon (OC) and water-soluble organic carbon (WSOC) in particles, show slight alterations in soot nanostructure, reduce soot ignition temperature and activation energy...
April 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28258928/inhaled-dry-powder-mannitol-in-children-with-cystic-fibrosis-a-randomised-efficacy-and-safety-trial
#8
K De Boeck, E Haarman, J Hull, L C Lands, A Moeller, A Munck, J Riethmüller, H Tiddens, S Volpi, J Leadbetter, B Charlton, A Malfroot
INTRODUCTION: Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This trial examined the efficacy of inhaled mannitol in children with cystic fibrosis (CF). METHODS: The efficacy of inhaled mannitol in children with CF aged 6-17years was assessed in a phase 2, randomised, placebo-controlled crossover study. Subjects were randomly assigned to mannitol 400mg every 12h or matching placebo for 8weeks, followed by an 8week washout and an 8week period with the alternate treatment...
February 28, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28225274/a-rational-design-of-a-selective-inhibitor-for-kv1-1-channels-prevalent-in-demyelinated-nerves-that-improves-their-impaired-axonal-conduction
#9
Ahmed Al-Sabi, Declan Daly, Patrick Hoefer, Gemma K Kinsella, Charles Metais, Mark Pickering, Caroline Herron, Seshu Kumar Kaza, Kieran Nolan, J Oliver Dolly
K(+) channels containing Kv1.1 α subunits, which become prevalent at internodes in demyelinated axons, may underlie their dysfunctional conduction akin to muscle weakness in multiple sclerosis. Small inhibitors were sought with selectivity for the culpable hyper-polarizing K(+) currents. Modeling of interactions with the extracellular pore in a Kv1.1-deduced structure identified diaryldi(2-pyrrolyl)methane as a suitable scaffold with optimized alkyl ammonium side chains. The resultant synthesized candidate [2,2'-((5,5'(di-p-topyldiaryldi(2-pyrrolyl)methane)bis(2,2'carbonyl)bis(azanediyl)) diethaneamine·2HCl] (8) selectively blocked Kv1...
March 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28166462/comparison-of-personal-diesel-and-biodiesel-exhaust-exposures-in-an-underground-mine
#10
Eric A Lutz, Rustin J Reed, Vivien S T Lee, Jefferey L Burgess
OBJECTIVE: This study aimed to compare personal exposures to diesel fuel and a biodiesel blend exhaust in an underground mine. METHODS: Personal exposure monitoring was performed in a non-operational, hard rock underground mine during use of a load-haul-dump vehicle. Eight-hour time-weighted average (TWA8) exposure concentrations of ultra-low sulfur diesel and 75% biodiesel/25% diesel blend (B75) fuels were compared. RESULTS: Compared to diesel, use of B75 was associated with relative percent reductions of 22 and 28% in median respirable (r) diesel particulate matter (DPM) and nitrogen dioxide and 25 and 23% increases in median total DPM and nitric oxide TWA8 exposure concentrations, respectively...
February 6, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28152694/using-a-disease-pathway-management-approach-to-improve-the-quality-of-breast-cancer-care-in-ontario
#11
Jasmin Soobrian, Ashley Tyrrell, Clement Li, Derek Muradali, Margaret F Forbes, Angelika Gollnow, Jillian Ross, Claire Holloway
109 Background: Disease Pathway Management (DPM) is used by Cancer Care Ontario (CCO) to set priorities for cancer control, plan cancer services, and improve the quality of care in Ontario by promoting standardization. The DPM approach applies a framework to examine the performance of the entire system from prevention to end of life care, and to identify any gaps within the system. In 2014, DPM began its breast cancer pathway initiative by mapping the patient journey, depicting evidence-based best practice along the breast cancer care continuum, identifying where further guidance is needed for clinical decision making, and identifying gaps in quality of care and performance measurement indicators...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152692/pathway-map-development-as-an-approach-to-identifying-priority-areas-for-quality-improvement-in-ontario
#12
Jasmin Soobrian, Joan Murphy, Lorraine Elit, Michael F Milosevic, Angelika Gollnow, Jillian Ross, Claire Holloway
108 Background: Disease Pathway Management (DPM) is the unifying approach to the way in which Cancer Care Ontario (CCO) sets priorities for cancer control, plans cancer services and improves the quality of care in Ontario. In 2014 DPM began developing a cervical cancer pathway map (CCPM) to map the patient journey along the cervical cancer care continuum. OBJECTIVE: to report on the CPPM development process as a tool to identify key priorities for cervical cancer management in Ontario...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28147238/endoscopic-evacuation-of-basal-ganglia-hematoma-surgical-technique-outcome-and-learning-curve
#13
LiChao Ma, YuanZheng Hou, RuYuan Zhu, XiaoLei Chen
BACKGROUND: Minimally invasive endoscopic hematoma evacuation is a promising treatment option for intracerebral hemorrhage. However, its technique still needs improvement. We report our clinical experience of utilizing this technique to evacuate deep-seated basal ganglia hematomas. METHODS: The frontal approach was used in the majority of patients. The preoperative and postoperative hematoma volumes, Glasgow Coma Scale (GCS), hematoma evacuation rate, 30-day mortality, and long-term outcome defined by the modified Rankin Scale were analyzed retrospectively...
January 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28056894/study-protocol-the-norfolk-diabetes-prevention-study-ndps-a-46%C3%A2-month-multi-centre-randomised-controlled-parallel-group-trial-of-a-lifestyle-intervention-with-or-without-additional-support-from-lay-lifestyle-mentors-with-type-2-diabetes-to-prevent-transition
#14
Melanie Pascale, Nikki Murray, Max Bachmann, Garry Barton, Allan Clark, Amanda Howe, Colin Greaves, Mike Sampson
BACKGROUND: This 7 year NIHR programme [2011-2018] tests the primary hypothesis that the NDPS diet and physical activity intervention will reduce the risk of transition to type 2 diabetes (T2DM) in groups at high risk of Type 2 diabetes. The NDPS programme recognizes the need to reduce intervention costs through group delivery and the use of lay mentors with T2DM, the realities of normal primary care, and the complexity of the current glycaemic categorisation of T2DM risk. METHODS: NDPS identifies people at highest risk of T2DM on the databases of 135 general practices in the East of England for further screening with ab fasting plasma glucose and glycosylated haemoglobin [HbA1c]...
January 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28046636/tu-ab-brc-10-modeling-of-radiotherapy-linac-source-terms-using-archer-monte-carlo-code-performance-comparison-of-gpu-and-mic-computing-accelerators
#15
T Liu, H Lin, L Su, C Shi, X Tang, B Bednarz, X Xu
PURPOSE: (1) To perform phase space (PS) based source modeling for Tomotherapy and Varian TrueBeam 6 MV Linacs, (2) to examine the accuracy and performance of the ARCHER Monte Carlo code on a heterogeneous computing platform with Many Integrated Core coprocessors (MIC, aka Xeon Phi) and GPUs, and (3) to explore the software micro-optimization methods. METHODS: The patient-specific source of Tomotherapy and Varian TrueBeam Linacs was modeled using the PS approach...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032777/a-diversified-portfolio-model-of-adaptability
#16
Siddharth Chandra, Frederick T L Leong
A new model of adaptability, the diversified portfolio model (DPM) of adaptability, is introduced. In the 1950s, Markowitz developed the financial portfolio model by demonstrating that investors could optimize the ratio of risk and return on their portfolios through risk diversification. The DPM integrates attractive features of a variety of models of adaptability, including Linville's self-complexity model, the risk and resilience model, and Bandura's social cognitive theory. The DPM draws on the concept of portfolio diversification, positing that diversified investment in multiple life experiences, life roles, and relationships promotes positive adaptation to life's challenges...
December 2016: American Psychologist
https://www.readbyqxmd.com/read/27998858/-interaction-of-polymorphisms-of-ppar-%C3%AE-2-gene-c34g-and-nadph-oxidase-subunit-p22phox-gene-c242t-with-helicobacter-pylori-infection-in-esophageal-squamous-cell-carcinoma
#17
Chao-Xian Zhang, Li-Ke Guo, Li-Li Zhang, Yu Han
OBJECTIVE: To investigate the interaction of polymorphisms of PPAR-γ2 gene -C34G and NADPH oxidase subunit p22phox gene -C242T with helicobacter pylori (H. pylori) infection in esophageal squamous cell carcinoma (ESCC) . METHODS: A total of 200 cases of LSCC of Broder grade I, 200 of Broder grade II and of grade III were enrolled in this study with 200 healthy individuals as the control group. The genetic polymorphisms of PPAR-γ2 gene -C34G and NADPH oxidase subunit p22phox gene -C242T were analyzed using PCR-RFLP in peripheral blood leukocytes...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27833135/a-simple-method-to-improve-the-stability-of-docetaxel-micelles
#18
Lan Zhang, LiWei Tan, LiJuan Chen, XiaoXin Chen, ChaoFeng Long, JinRong Peng, ZhiYong Qian
Self-assembled polymeric micelles have been widely applied in drug delivery systems. In this study, we found that pH value of micellar system solution was the decisive factor of physical stability. Furthermore, the weak basic solution could maintain the solution clarification for a relative long time. To investigate the stability of polymeric micelles in different pH solutions, the micellar particle size and the docetaxel content remaining in solution were detected at predetermined time points. The crystallographic assay of freeze-drying powder was characterized by an X-ray diffractometer...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27809929/insight-of-brain-degenerative-protein-modifications-in-the-pathology-of-neurodegeneration-and-dementia-by-proteomic-profiling
#19
REVIEW
Sunil S Adav, Siu Kwan Sze
Dementia is a syndrome associated with a wide range of clinical features including progressive cognitive decline and patient inability to self-care. Due to rapidly increasing prevalence in aging society, dementia now confers a major economic, social, and healthcare burden throughout the world, and has therefore been identified as a public health priority by the World Health Organization. Previous studies have established dementia as a 'proteinopathy' caused by detrimental changes in brain protein structure and function that promote misfolding, aggregation, and deposition as insoluble amyloid plaques...
November 3, 2016: Molecular Brain
https://www.readbyqxmd.com/read/27808266/integrative-omics-connects-n-glycoproteome-wide-alterations-with-pathways-and-regulatory-events-in-induced-pluripotent-stem-cells
#20
Putty-Reddy Sudhir, Madireddy Pavana Kumari, Wei-Ting Hsu, Chein-Hung Chen, Hung-Chih Kuo, Chung-Hsuan Chen
Molecular-level differences ranging from genomes to proteomes, but not N-glycoproteomes, between human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs) have been assessed to gain insights into cell reprogramming and induced pluripotency. Our multiplexed quantitative N-glycoproteomics study identified altered N-glycoproteins that significantly regulate cell adhesion processes in hiPSCs compared to hESCs. The integrative proteomics and functional network analyses of the altered N-glycoproteins revealed their significant interactions with known PluriNet (pluripotency-associated network) proteins...
November 3, 2016: Scientific Reports
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