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https://www.readbyqxmd.com/read/28166462/comparison-of-personal-diesel-and-biodiesel-exhaust-exposures-in-an-underground-mine
#1
Eric A Lutz, Rustin J Reed, Vivien S T Lee, Jefferey L Burgess
OBJECTIVE: This study aimed to compare personal exposures to diesel fuel and a biodiesel blend exhaust in an underground mine. METHODS: Personal exposure monitoring was performed in a non-operational, hard rock underground mine during use of a load-haul-dump vehicle. Eight-hour time-weighted average (TWA8) exposure concentrations of ultra-low sulfur diesel and 75% biodiesel/25% diesel blend (B75) fuels were compared. RESULTS: Compared to diesel, use of B75 was associated with relative percent reductions of 22 and 28% in median respirable (r) diesel particulate matter (DPM) and nitrogen dioxide and 25 and 23% increases in median total DPM and nitric oxide TWA8 exposure concentrations, respectively...
February 6, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28152694/using-a-disease-pathway-management-approach-to-improve-the-quality-of-breast-cancer-care-in-ontario
#2
Jasmin Soobrian, Ashley Tyrrell, Clement Li, Derek Muradali, Margaret F Forbes, Angelika Gollnow, Jillian Ross, Claire Holloway
: 109 Background: Disease Pathway Management (DPM) is used by Cancer Care Ontario (CCO) to set priorities for cancer control, plan cancer services, and improve the quality of care in Ontario by promoting standardization. The DPM approach applies a framework to examine the performance of the entire system from prevention to end of life care, and to identify any gaps within the system. In 2014, DPM began its breast cancer pathway initiative by mapping the patient journey, depicting evidence-based best practice along the breast cancer care continuum, identifying where further guidance is needed for clinical decision making, and identifying gaps in quality of care and performance measurement indicators...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152692/pathway-map-development-as-an-approach-to-identifying-priority-areas-for-quality-improvement-in-ontario
#3
Jasmin Soobrian, Joan Murphy, Lorraine Elit, Michael F Milosevic, Angelika Gollnow, Jillian Ross, Claire Holloway
: 108 Background: Disease Pathway Management (DPM) is the unifying approach to the way in which Cancer Care Ontario (CCO) sets priorities for cancer control, plans cancer services and improves the quality of care in Ontario. In 2014 DPM began developing a cervical cancer pathway map (CCPM) to map the patient journey along the cervical cancer care continuum. OBJECTIVE: to report on the CPPM development process as a tool to identify key priorities for cervical cancer management in Ontario...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28147238/endoscopic-evacuation-of-basal-ganglia-hematoma-surgical-technique-outcome-and-learning-curve
#4
LiChao Ma, YuanZheng Hou, RuYuan Zhu, XiaoLei Chen
BACKGROUND: Minimally invasive endoscopic hematoma evacuation is a promising treatment option for intracerebral hemorrhage. However, its technique still needs improvement. We report our clinical experience of utilizing this technique to evacuate deep-seated basal ganglia hematomas. METHODS: The frontal approach was used in the majority of patients. The preoperative and postoperative hematoma volumes, Glasgow Coma Scale (GCS), hematoma evacuation rate, 30-day mortality, and long-term outcome defined by the modified Rankin Scale were analyzed retrospectively...
January 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28056894/study-protocol-the-norfolk-diabetes-prevention-study-ndps-a-46%C3%A2-month-multi-centre-randomised-controlled-parallel-group-trial-of-a-lifestyle-intervention-with-or-without-additional-support-from-lay-lifestyle-mentors-with-type-2-diabetes-to-prevent-transition
#5
Melanie Pascale, Nikki Murray, Max Bachmann, Garry Barton, Allan Clark, Amanda Howe, Colin Greaves, Mike Sampson
BACKGROUND: This 7 year NIHR programme [2011-2018] tests the primary hypothesis that the NDPS diet and physical activity intervention will reduce the risk of transition to type 2 diabetes (T2DM) in groups at high risk of Type 2 diabetes. The NDPS programme recognizes the need to reduce intervention costs through group delivery and the use of lay mentors with T2DM, the realities of normal primary care, and the complexity of the current glycaemic categorisation of T2DM risk. METHODS: NDPS identifies people at highest risk of T2DM on the databases of 135 general practices in the East of England for further screening with ab fasting plasma glucose and glycosylated haemoglobin [HbA1c]...
January 6, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28046636/tu-ab-brc-10-modeling-of-radiotherapy-linac-source-terms-using-archer-monte-carlo-code-performance-comparison-of-gpu-and-mic-computing-accelerators
#6
T Liu, H Lin, L Su, C Shi, X Tang, B Bednarz, X Xu
PURPOSE: (1) To perform phase space (PS) based source modeling for Tomotherapy and Varian TrueBeam 6 MV Linacs, (2) to examine the accuracy and performance of the ARCHER Monte Carlo code on a heterogeneous computing platform with Many Integrated Core coprocessors (MIC, aka Xeon Phi) and GPUs, and (3) to explore the software micro-optimization methods. METHODS: The patient-specific source of Tomotherapy and Varian TrueBeam Linacs was modeled using the PS approach...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032777/a-diversified-portfolio-model-of-adaptability
#7
Siddharth Chandra, Frederick T L Leong
A new model of adaptability, the diversified portfolio model (DPM) of adaptability, is introduced. In the 1950s, Markowitz developed the financial portfolio model by demonstrating that investors could optimize the ratio of risk and return on their portfolios through risk diversification. The DPM integrates attractive features of a variety of models of adaptability, including Linville's self-complexity model, the risk and resilience model, and Bandura's social cognitive theory. The DPM draws on the concept of portfolio diversification, positing that diversified investment in multiple life experiences, life roles, and relationships promotes positive adaptation to life's challenges...
December 2016: American Psychologist
https://www.readbyqxmd.com/read/27998858/-interaction-of-polymorphisms-of-ppar-%C3%AE-2-gene-c34g-and-nadph-oxidase-subunit-p22phox-gene-c242t-with-helicobacter-pylori-infection-in-esophageal-squamous-cell-carcinoma
#8
Chao-Xian Zhang, Li-Ke Guo, Li-Li Zhang, Yu Han
OBJECTIVE: To investigate the interaction of polymorphisms of PPAR-γ2 gene -C34G and NADPH oxidase subunit p22phox gene -C242T with helicobacter pylori (H. pylori) infection in esophageal squamous cell carcinoma (ESCC) . METHODS: A total of 200 cases of LSCC of Broder grade I, 200 of Broder grade II and of grade III were enrolled in this study with 200 healthy individuals as the control group. The genetic polymorphisms of PPAR-γ2 gene -C34G and NADPH oxidase subunit p22phox gene -C242T were analyzed using PCR-RFLP in peripheral blood leukocytes...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27833135/a-simple-method-to-improve-the-stability-of-docetaxel-micelles
#9
Lan Zhang, LiWei Tan, LiJuan Chen, XiaoXin Chen, ChaoFeng Long, JinRong Peng, ZhiYong Qian
Self-assembled polymeric micelles have been widely applied in drug delivery systems. In this study, we found that pH value of micellar system solution was the decisive factor of physical stability. Furthermore, the weak basic solution could maintain the solution clarification for a relative long time. To investigate the stability of polymeric micelles in different pH solutions, the micellar particle size and the docetaxel content remaining in solution were detected at predetermined time points. The crystallographic assay of freeze-drying powder was characterized by an X-ray diffractometer...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27809929/insight-of-brain-degenerative-protein-modifications-in-the-pathology-of-neurodegeneration-and-dementia-by-proteomic-profiling
#10
REVIEW
Sunil S Adav, Siu Kwan Sze
Dementia is a syndrome associated with a wide range of clinical features including progressive cognitive decline and patient inability to self-care. Due to rapidly increasing prevalence in aging society, dementia now confers a major economic, social, and healthcare burden throughout the world, and has therefore been identified as a public health priority by the World Health Organization. Previous studies have established dementia as a 'proteinopathy' caused by detrimental changes in brain protein structure and function that promote misfolding, aggregation, and deposition as insoluble amyloid plaques...
November 3, 2016: Molecular Brain
https://www.readbyqxmd.com/read/27808266/integrative-omics-connects-n-glycoproteome-wide-alterations-with-pathways-and-regulatory-events-in-induced-pluripotent-stem-cells
#11
Putty-Reddy Sudhir, Madireddy Pavana Kumari, Wei-Ting Hsu, Chein-Hung Chen, Hung-Chih Kuo, Chung-Hsuan Chen
Molecular-level differences ranging from genomes to proteomes, but not N-glycoproteomes, between human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs) have been assessed to gain insights into cell reprogramming and induced pluripotency. Our multiplexed quantitative N-glycoproteomics study identified altered N-glycoproteins that significantly regulate cell adhesion processes in hiPSCs compared to hESCs. The integrative proteomics and functional network analyses of the altered N-glycoproteins revealed their significant interactions with known PluriNet (pluripotency-associated network) proteins...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27800567/investigation-of-the-dissolution-profile-of-gliclazide-modified-release-tablets-using-different-apparatuses-and-dissolution-conditions
#12
K K S Skripnik, M K Riekes, B R Pezzini, S G Cardoso, H K Stulzer
In the absence of an official dissolution method for modified-release tablets of gliclazide, dissolution parameters, such as apparatuses (1, 2, and 3), rotation speeds, pH, and composition of the dissolution medium were investigated. The results show that although the drug presents a pH-mediated solubility (pH 7.0 > 6.8 > 6.4 > 6.0 > 5.5 > 4.5), the in vitro release of the studied tablets was not dependent on this parameter, despite of the apparatus tested. On the other hand, the rotation speed demonstrated a greater influence (100 rpm >50 rpm)...
October 31, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27756369/tracing-the-decision-making-process-of-physicians-with-a-decision-process-matrix
#13
Daniel Hausmann, Cristina Zulian, Edouard Battegay, Lukas Zimmerli
BACKGROUND: Decision-making processes in a medical setting are complex, dynamic and under time pressure, often with serious consequences for a patient's condition. OBJECTIVE: The principal aim of the present study was to trace and map the individual diagnostic process of real medical cases using a Decision Process Matrix [DPM]). METHODS: The naturalistic decision-making process of 11 residents and a total of 55 medical cases were recorded in an emergency department, and a DPM was drawn up according to a semi-structured technique following four steps: 1) observing and recording relevant information throughout the entire diagnostic process, 2) assessing options in terms of suspected diagnoses, 3) drawing up an initial version of the DPM, and 4) verifying the DPM, while adding the confidence ratings...
October 18, 2016: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/27722588/photochemical-site-selective-synthesis-of-70-methanofullerenes
#14
Sara Vidal, Marta Izquierdo, Wai Kit Law, Kui Jiang, Salvatore Filippone, Josefina Perles, He Yan, Nazario Martín
Methanofullerenes such as the well-known [70]PCBM are commonly synthesized under harsh conditions to obtain the product as a mixture of site-isomers (namely α, β and minor γ) due to the D5h symmetry of the C70 cage. We report the first site-selective synthesis of [70]methanofullerenes under light irradiation and low temperatures, thus avoiding time-consuming and highly expensive HPLC separations. Pure major site-isomers α-[70]PCBM and α-[70]DPM have been thus efficiently prepared including the crystal structure of 5b...
October 10, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27681807/viable-intact-cryopreserved-human-placental-membrane-for-a-non-surgical-approach-to-closure-in-complex-wounds
#15
K Suzuki, G Michael, Y Tamire
OBJECTIVE: Advances in wound treatment have yielded successful approaches to complex wound closure through plastic surgery or other staged surgical methods. However, not all patients or wounds are candidates for such increasingly rigorous levels of interventions. The exploration of non-surgical treatment options that promote anatomical and functional tissue replacement on an outpatient basis without donor site morbidity is necessary to maximise opportunities for patient mobility and rehabilitation...
October 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27676387/using-bayesian-hierarchical-models-to-better-understand-nitrate-sources-and-sinks-in-agricultural-watersheds
#16
Yongqiu Xia, Donald E Weller, Meghan N Williams, Thomas E Jordan, Xiaoyuan Yan
Export coefficient models (ECMs) are often used to predict nutrient sources and sinks in watersheds because ECMs can flexibly incorporate processes and have minimal data requirements. However, ECMs do not quantify uncertainties in model structure, parameters, or predictions; nor do they account for spatial and temporal variability in land characteristics, weather, and management practices. We applied Bayesian hierarchical methods to address these problems in ECMs used to predict nitrate concentration in streams...
November 15, 2016: Water Research
https://www.readbyqxmd.com/read/27629706/drosophila-neprilysins-are-involved-in-middle-term-and-long-term-memory
#17
Oriane Turrel, Aurélie Lampin-Saint-Amaux, Thomas Préat, Valérie Goguel
UNLABELLED: Neprilysins are type II metalloproteinases known to degrade and inactivate a number of small peptides. Neprilysins in particular are the major amyloid-β peptide-degrading enzymes. In mouse models of Alzheimer's disease, neprilysin overexpression improves learning and memory deficits, whereas neprilysin deficiency aggravates the behavioral phenotypes. However, whether these enzymes are involved in memory in nonpathological conditions is an open question. Drosophila melanogaster is a well suited model system with which to address this issue...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27587701/bayesian-parameter-estimation-for-the-wnt-pathway-an-infinite-mixture-models-approach
#18
Konstantinos Koutroumpas, Paolo Ballarini, Irene Votsi, Paul-Henry Cournède
MOTIVATION: Likelihood-free methods, like Approximate Bayesian Computation (ABC), have been extensively used in model-based statistical inference with intractable likelihood functions. When combined with Sequential Monte Carlo (SMC) algorithms they constitute a powerful approach for parameter estimation and model selection of mathematical models of complex biological systems. A crucial step in the ABC-SMC algorithms, significantly affecting their performance, is the propagation of a set of parameter vectors through a sequence of intermediate distributions using Markov kernels...
September 1, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27561878/highly-increased-125i-jr11-antagonist-binding-in-vitro-reveals-novel-indications-for-sst2-targeting-in-human-cancers
#19
Jean Claude Reubi, Beatrice Waser, Helmut R Maecke, Jean E Rivier
: There is recent in vitro and in vivo evidence that somatostatin receptor sst2 antagonists are better tools to target neuroendocrine tumors (NET) than sst2 agonists. Indeed, antagonists bind to a greater number of sst2 sites than agonists. Whether sst2 antagonists could be used successfully to target non-NET tumors, expressing low sst2 density, is unknown. Here, we compare quantitatively (125)I-JR11 sst2 antagonist binding in vitro with that of the sst2 agonist (125)I-Tyr3-octreotide in large varieties of non-NET and NET...
August 25, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27502896/novel-approaches-to-characterize-age-related-remodelling-of-the-dermal-epidermal-junction-in-2d-3d-and-in-vivo
#20
V L Newton, R S Bradley, P Seroul, M Cherel, C E M Griffiths, A V Rawlings, R Voegeli, R E B Watson, M J Sherratt
BACKGROUND/PURPOSE: The dermal-epidermal junction (DEJ) forms epidermal protrusions down into the dermis (rete ridges) and dermal projections up into the epidermis (dermal papillae). Usually visualized in two-dimensions (2D), our knowledge of how the DEJ changes with ageing is limited. We aimed to characterize how this structure exists in 3D and changes with age. METHODS: Photoprotected and photoexposed skin were imaged using reflectance confocal microscopy (RCM) in young and aged individuals...
August 9, 2016: Skin Research and Technology
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