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Guglielmo Fernandez Garcia, Alessandro Lunghi, Federico Totti, Roberta Sessoli
Here we present a computational study of a full- and a half-monolayer of a Fe4 single molecule magnet ([Fe4(L)2(dpm)6], where H3L = 2-hydroxymethyl-2-phenylpropane-1,3-diol and Hdpm = dipivaloylmethane, Fe4Ph) on an unreconstructed surface of Au(111). This has been possible through the application of an integrated approach, which allows the explicit inclusion of the packing effects in the classical dynamics to be used in a second step in periodic and non-periodic high level DFT calculations. In this way we can obtain access to mesoscale geometrical data and verify how they can influence the magnetic properties of interest of the single Fe4 molecule...
February 12, 2018: Nanoscale
Ebube E Obi, Oyinkan Olurin, Peter M Mota, Zuzana Sipkova, Oana Vonica, Andrew R Pearson
Lacrimal surgery aims to provide a low-resistance tear drainage passage. An assessment of lacrimal resistance guides decisions on surgery. We present results of a modified tear duct irrigation system that reliably measures lacrimal outflow resistance. Patients in a specialist lacrimal clinic had a full work-up to the point of tear duct syringing. The tear ducts were irrigated using a manometric system, which applied a fixed, known head of fluid pressure to a lacrimal cannula. Fluid flow is recorded and the lacrimal resistance derived as fluid pressure/fluid flow (units cmH20 secml-1, for simplicity presented as drops per minute, dpm)...
February 6, 2018: Orbit
Mari Sekiya, Kazuhiko Sakamoto, Satoshi Matsukuma, Yoshihiro Tokuhisa, Yukio Tokumitsu, Hiroto Matsui, Shinsuke Kanekiyo, Shinobu Tomochika, Michihisa Iida, Shigeru Takeda, Nobuaki Suzuki, Shigefumi Yoshino, Shoichi Hazama, Yoshinobu Hoshii, Hiroaki Nagano
A 56-year-old man with HCV infection was referred to our hospital for further evaluation and treatment of hepatic tumor. Abdominal enhanced computed tomography demonstrated an S8 hepatic tumor, about 15mm in maximal diameter. The tumor showed enhancement on the arterial phase and washout on equilibrium phase. EOB-MRI scan also showed the hepatic tumor with enhancement in the early phase and washout in the delayed phase. Liver function was normal. Serum AFP and PIVKA- II were normal and CEA and CA19-9 were elevated...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
S Yalcin, K Şahin, M Tuzcu, G Bilgen, S Özkan, G T İzzetoğlu, R Işik
1. The objective of this study was to determine muscle structure and gene expression in pectoralis major (p. major) muscle of broilers in response to deep pectoral myopathy (DPM) induction. 2. A total of 160 chickens from slow- and fast-growing broilers were raised under same conditions. Half of the broilers from each strain were encouraged to wing flap when they reached to 2800 g body weight. Pectoralis minor (p. minor) muscle of the broilers was inspected for the occurrence of DPM and p. major samples were collected from broilers with or without DPM...
January 22, 2018: British Poultry Science
Mang Lin, Mark H Thiemens
An ultra-low-level liquid scintillation counting (LSC) technique has been used in measuring radiosulfur (cosmogenic 35S) in natural samples. The ideal half-life of 35S (~87 d) renders it a new way to examine various biogeochemical problems. A major limit of the technique is that complex chemical compositions in atmospheric samples may lead to color quenching of LSC cocktails, a serious problem prolonging the pretreatment time (>1 week) and hampering the accurate determination of 35S. For application of the technique where many of the most important atmospheric chemical processes are examined, significant interferences arise and accurate analysis in small samples is not possible...
January 19, 2018: Analytical Chemistry
Erin A Riley, Emily E Carpenter, Joemy Ramsay, Emily Zamzow, Christopher Pyke, Michael H Paulsen, Lianne Sheppard, Terry M Spear, Noah S Seixas, Dale J Stephenson, Christopher D Simpson
We investigated the viability of particle bound 1-nitropyrene (1-NP) air concentration measurements as a surrogate of diesel exhaust (DE) exposure, as compared with industry-standard elemental carbon (EC) and total carbon (TC) measurements. Personal exposures are reported for 18 employees at a large underground metal mine during four different monitoring campaigns. Full-shift personal air exposure sampling was conducted using a Mine Safety and Health Administration (MSHA) compliant diesel particulate matter (DPM) impactor cassette downstream of a GS-1 cyclone pre-selector...
December 30, 2017: Annals of Work Exposures and Health
Jun-Yi Wu, Show-An Chen
We use the mixed host, 2,6-bis(3(carbazol9yl)phenyl)pyridine (26DCzPPy) blending with 20 wt % tris(4-carbazoyl-9- ylphenyl) amine (TCTA) for lowering hole-injection barrier, along with the bipolar and high photoluminescence quantum yield (Φp= 84 %) blue TADF material of 9,9-dimethyl-9,10-dihydroacridine-2,4,6-triphenyl-1,3,5-triazine (DMAC-TRZ) as blue dopant to compose of the emission layer for fabricating the TADF blue organic light emitting diode (BOLED). The device realizes highly efficient device with the performance parameters: maximum brightness (Bmax) 57586 cd/m2, maximum current efficiency (CEmax) 35...
December 29, 2017: ACS Applied Materials & Interfaces
Ruonan Bai, Abdellah Alem, Hervé Franklin, Alain Tinel, Huaqing Wang, Fatima Kachkouch, Said Taibi, Laurent Bizet
A study was undertaken to characterise the evolution of the clogging of various porous media during filtration experiments. Long term tracer tests were carried out at various flow velocities. To highlight the effects of intraporosity on transport and retention mechanisms, both single porosity and double porosity media (DPM) were used. The presence of matrix porosity in the two investigated DPM provided additional sites, promoting retention of suspended particles (SP). The particle size distribution (PSD) of the recovered particles increased with time...
December 15, 2017: Environmental Technology
Youngmin Kim, Ki-Seong Lee, Chan-Gun Lee
In wireless sensor networks (WSNs), sensor nodes are deployed for collecting and analyzing data. These nodes use limited energy batteries for easy deployment and low cost. The use of limited energy batteries is closely related to the lifetime of the sensor nodes when using wireless sensor networks. Efficient-energy management is important to extending the lifetime of the sensor nodes. Most effort for improving power efficiency in tiny sensor nodes has focused mainly on reducing the power consumed during data transmission...
December 14, 2017: Sensors
Ronél van der Watt, Carina Pheiffer, Stephen Brown
Children living with a congenital heart defect (CHD) carry the burden of a condition affecting their biological, psychological, and social functioning. Even though the physical heartbeats of these children might be inaudible and defective, their intra- and inter-personal 'stories in sound' need to be heard and understood. The aim of this research study was to explore these 'stories in sound' in children diagnosed with CHD. A qualitative, exploratory, descriptive study using thematic analysis was conducted. Semi-structured interviews were conducted with six boys and three girls between the ages of eight and fourteen years, who were diagnosed with CHD...
November 2017: Journal of Child and Adolescent Mental Health
Alexa Schmitz, Kai Schütte, Vesko Ilievski, Juri Barthel, Laura Burk, Rolf Mülhaupt, Junpei Yue, Bernd Smarsly, Christoph Janiak
Metal-fluoride nanoparticles, (MF x -NPs) with M = Fe, Co, Pr, Eu, supported on different types of thermally reduced graphite oxide (TRGO) were obtained by microwave-assisted thermal decomposition of transition-metal amidinates, (M{MeC[N(iPr)]2} n ) or [M(AMD) n ] with M = Fe(II), Co(II), Pr(III), and tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium, Eu(dpm)3, in the presence of TRGO in the ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIm][BF4]). The crystalline phases of the metal fluorides synthesized in [BMIm][BF4] were identified by powder X-ray diffraction (PXRD) to be MF2 for M = Fe, Co and MF3 for M = Eu, Pr...
2017: Beilstein Journal of Nanotechnology
Sarvenaz Sheikh, Joe Iwanaga, Jocelyn R Gonzales, Tsuyoshi Saga, Marios Loukas, Rod J Oskouian, R Shane Tubbs
Direct insertion of the anterior papillary muscle (DPM) into the mitral valve is uncommon. During the routine dissection of an adult female, a DPM into the mitral valve with abnormal chordae tendinae was observed. This abnormal papillary muscle was measured as 28.0 mm in length from myocardial to insertion, 14.8 mm in width, and 7.0 mm in depth. The embryology, symptoms, associated cardiac diseases, and surgical precautions of this congenital malformation in the heart are reviewed.
October 5, 2017: Curēus
Navasona Krishnan, Konstantis F Konidaris, Gilles Gasser, Nicholas K Tonks
The protein tyrosine phosphatase PTP1B is a negative regulator of insulin and leptin signaling, and a highly validated therapeutic target for diabetes and obesity. Conventional approaches to drug development have produced potent and specific PTP1B inhibitors, but these inhibitors lack oral bioavailability, which limits their potential for drug development. Here we report that DPM-1001, an analogue of the specific PTP1B inhibitor trodusquemine (MSI-1436), is a potent, specific and orally bioavailable inhibitor of PTP1B...
December 7, 2017: Journal of Biological Chemistry
Shrawan Baghel, Helen Cathcart, Niall J O'Reilly
In this study, the dissolution behaviour of dipyridamole (DPM) and cinnarizine (CNZ) spray-dried amorphous solid dispersions (ASDs) using polyvinyl pyrrolidone (PVP) and polyacrylic acid (PAA) as a carrier matrix were evaluated and compared. The drug concentrations achieved from the dissolution of PVP and PAA solid dispersions were significantly greater than the equilibrium solubility of crystalline DPM and CNZ in phosphate buffer pH 6.8 (PBS 6.8). The maximum drug concentration achieved by dissolution of PVP and PAA solid dispersions did not exceed the theoretically calculated apparent solubility of amorphous DPM and CNZ...
November 25, 2017: International Journal of Pharmaceutics
Louise Kiru, Tae Jin Kim, Bin Shen, Frederick T Chin, Guillem Pratx
PURPOSE: Cell-based therapies are showing great promise for a variety of diseases, but remain hindered by the limited information available regarding the biological fate, migration routes and differentiation patterns of infused cells in trials. Previous studies have demonstrated the feasibility of using positron emission tomography (PET) to track single cells utilising an approach known as positron emission particle tracking (PEPT). The radiolabel hexadecyl-4-[(18)F]fluorobenzoate ([(18)F]HFB) was identified as a promising candidate for PEPT, due to its efficient and long-lasting labelling capabilities...
November 15, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Zhaoran Hao, Fanyuan Meng, Pu Wang, Yafei Wang, Hua Tan, Yong Pei, Shijian Su, Yu Liu
Two novel mono- and binuclear cyclometalated platinum(ii) complexes of (BuPyrDPy)Pt(dpm) and (BuPyrDPy)[Pt(dpm)]2 incorporating a pyrenyl-dipyridine-based cyclometalated ligand were synthesized and characterized, respectively. Single-crystal X-ray diffraction of the two materials revealed each complex's coordination mode; their photophysical, electrochemical as well as electroluminescent properties were also investigated. Both complexes exhibited good solubility and excellent thermal stability. (BuPyrDPy)[Pt(dpm)]2 presented dual phosphorescence emissive character at room-temperature and showed an increased quantum efficiency compared to that of (BuPyrDPy)Pt(dpm)...
November 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
S Yalcin, S Ozkan, M C Acar, O Meral
1. Two experiments were conducted to determine the effect of slaughter weight on the incidence and intensity of deep pectoral myopathy (DPM) of M. pectoralis minor (p. minor muscle) in commercial conditions in Turkey and to evaluate the impact of DPM on meat quality traits of pectoralis major (p. major) muscle in broilers. 2. In Experiment 1, a total of 116 250 carcasses from 59 Ross-308 broiler flocks, classified according to slaughter weight as 2.0-2.2, 2.2-2.4, 2.4-2.6 and >2.6 kg, were evaluated for occurrence of DPM...
November 8, 2017: British Poultry Science
Balwinder Kaur, Cristiane Andreia Erdmann, Mathias Daniëls, Wim Dehaen, Zbigniew Rafiński, Hanna Radecka, Jerzy Radecki
In the present work, gold electrodes were modified using a redox-active layer based on dipyrromethene complexes with Cu(II) or Co(II) and a dipodal anion receptor functionalized with dipyrromethene. These modified gold electrodes were then applied for the electrochemical detection of anions (Cl(-), SO4(2-), and Br(-)) in a highly diluted water solution (in the picomolar range). The results showed that both systems, incorporating Cu(II) as well as Co(II) redox centers, exhibited highest sensitivity toward Cl(-)...
November 15, 2017: Analytical Chemistry
Jingxu Guo, Peter Erskine, Alun R Coker, Steve P Wood, Jonathan B Cooper
The enzyme porphobilinogen deaminase (PBGD) is one of the key enzymes in tetrapyrrole biosynthesis. It catalyses the formation of a linear tetrapyrrole from four molecules of the substrate porphobilinogen (PBG). It has a dipyrromethane cofactor (DPM) in the active site which is covalently linked to a conserved cysteine residue through a thioether bridge. The substrate molecules are linked to the cofactor in a stepwise head-to-tail manner during the reaction, which is catalysed by a conserved aspartate residue: Asp82 in the B...
November 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
Marco Lorenzi, Maurizio Filippone, Giovanni B Frisoni, Daniel C Alexander, Sebastien Ourselin
Disease progression modeling (DPM) of Alzheimer's disease (AD) aims at revealing long term pathological trajectories from short term clinical data. Along with the ability of providing a data-driven description of the natural evolution of the pathology, DPM has the potential of representing a valuable clinical instrument for automatic diagnosis, by explicitly describing the biomarker transition from normal to pathological stages along the disease time axis. In this work we reformulated DPM within a probabilistic setting to quantify the diagnostic uncertainty of individual disease severity in an hypothetical clinical scenario, with respect to missing measurements, biomarkers, and follow-up information...
October 24, 2017: NeuroImage
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