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https://www.readbyqxmd.com/read/29787431/rapid-response-dose-assessment-and-clinical-management-of-a-plutonium-contaminated-puncture-wound
#1
Stephen L Sugarman, William M Findley, Richard E Toohey, Nicholas Dainiak
Internalization of radionuclides occurs not only by inhalation, ingestion, parenteral injection (i.e., administration of radioactive material for a medical purpose), and direct transdermal absorption, but also by contaminated wounds. In June 2010, a glove-box operator at the U.S. Department of Energy's Savannah River Site sustained a puncture wound while venting canisters containing legacy materials contaminated with Pu. To indicate the canisters had been vented, a flag was inserted into the vent hole. The shaft of the flag penetrated the protective gloves worn by the operator...
July 2018: Health Physics
https://www.readbyqxmd.com/read/29768009/use-of-dual-ligand-modification-in-kupffer-cell-targeted-liposomes-to-examine-the-contribution-of-kupffer-cells-to-accelerated-blood-clearance-abc-phenomenon
#2
Chaoyang Lai, Cong Li, Xiang Luo, Mengyang Liu, Xinrong Liu, Ling Hu, Le Kang, Qiujun Qiu, Yihui Deng, Yanzhi Song
The "accelerated blood clearance (ABC) phenomenon" is known to be involved in the adaptive immune system. Regretfully, the relationship between the ABC phenomenon and innate immune system, especially with respect to Kupffer cells (KCs) has been largely unexplored. In this study, the contribution of KCs to ABC was examined using the 4-aminophenyl-α-D-mannopyranoside (APM) lipid derivative DSPE-PEG2000-APM (DPM) and the 4-aminophenyl-β-L-fucopyranoside (APF) lipid derivative DSPE-PEG2000-APF (DPF) as ligands for mannose/fucose receptors on KCs, which were synthesized and modified on the surface of liposomes...
May 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29761523/a-novel-cognitive-disease-progression-model-for-clinical-trials-in-autosomal-dominant-alzheimer-s-disease
#3
Guoqiao Wang, Scott Berry, Chengjie Xiong, Jason Hassenstab, Melanie Quintana, Eric M McDade, Paul Delmar, Matteo Vestrucci, Gopalan Sethuraman, Randall J Bateman
Clinical trial outcomes for Alzheimer's disease are typically analyzed by using the mixed model for repeated measures (MMRM) or similar models that compare an efficacy scale change from baseline between treatment arms with or without participants' disease stage as a covariate. The MMRM focuses on a single-point fixed follow-up duration regardless of the exposure for each participant. In contrast to these typical models, we have developed a novel semiparametric cognitive disease progression model (DPM) for autosomal dominant Alzheimer's disease based on the Dominantly Inherited Alzheimer Network (DIAN) observational study...
May 14, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29738497/a-cooperative-search-and-coverage-algorithm-with-controllable-revisit-and-connectivity-maintenance-for-multiple-unmanned-aerial-vehicles
#4
Zhong Liu, Xiaoguang Gao, Xiaowei Fu
In this paper, we mainly study a cooperative search and coverage algorithm for a given bounded rectangle region, which contains several unknown stationary targets, by a team of unmanned aerial vehicles (UAVs) with non-ideal sensors and limited communication ranges. Our goal is to minimize the search time, while gathering more information about the environment and finding more targets. For this purpose, a novel cooperative search and coverage algorithm with controllable revisit mechanism is presented. Firstly, as the representation of the environment, the cognitive maps that included the target probability map (TPM), the uncertain map (UM), and the digital pheromone map (DPM) are constituted...
May 8, 2018: Sensors
https://www.readbyqxmd.com/read/29726843/functional-graded-fullerene-derivatives-for-improving-the-fill-factor-and-device-stability-of-inverted-type-perovskite-solar-cells
#5
Kuo Yuan Chiu, Sheng Hsiung Chang, Wei-Chen Huang, Hsin-Ming Cheng, Hsin Shaw, Shih-Chieh Yeh, Chin-Ti Chen, Yuhlong Oliver Su, Sheng-Hui Chen, Chun-Guey Wu
A graded fullerene derivative thin film was used as a dual-functional electron transport layer (ETL) in CH3NH3PbI3 (MAPbI3) solar cells, to improve the fill factor and device stability. The graded ETL was made by mixing phenyl-C61-butyric acid methyl ester (PCBM) molecules and C60-diphenylmethanofullerene-oligoether (C60-DPM-OE) molecules using the spin-coating method. The formation of the graded ETLs can be due to the phase separation between hydrophobic PCBM and hydrophilic C60-DPM-OE, which was confirmed by XPS depth-profile analysis and an electron energy-loss spectroscope...
May 4, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29726504/removal-of-millimeter-scale-rolled-edges-using-bevel-cut-like-tool-influence-function-in-magnetorheological-jet-polishing
#6
Hao Yang, Haobo Cheng, Yunpeng Feng, Xiaoli Jing
Subaperture polishing techniques usually produce rolled edges due to edge effect. The rolled edges, especially those in millimeter scale on small components, are difficult to eliminate using conventional polishing methods. Magnetorheological jet polishing (MJP) offers the possibility of the removal of these structures, owing to its small tool influence function (TIF) size. Hence, we investigate the removal characters of inclined MJP jetting models by means of computational fluid dynamics (CFD) simulations and polishing experiments...
May 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29723587/duplex-ultrasound-guided-direct-percutaneous-management-of-pseudoaneurysm-of-branch-of-segmental-renal-artery-technique-and-its-outcome
#7
Kumar Manoj, Gaurav Garg, Deepak Nagathan, Sanjeev Kumar Verma, Neera Kohli, Santosh Kumar, Sant Kumar Pandey, Satya Narayan Sankhwar
OBJECTIVE: To describe the role of Duplex-Ultrasound Imaging (DUI) in prompt diagnosis of pseudoaneurysm (PSA) of a branch of the segmental renal artery (b-SRA) and evaluate outcomes of DUI directed percutaneous embolization. METHODS: Forty-five patients were referred to us for the management of intractable renal hematuria. 20 cases (44.44%) had developed PSA after nephrolithotomy. 12 cases (12.66%) had developed PSA after guided renal biopsies. 6 cases (13.33%) had developed PSA following road side trauma...
April 30, 2018: Urology
https://www.readbyqxmd.com/read/29696536/transgenic-up-regulation-of-claudin-6-decreases-fine-diesel-particulate-matter-dpm-induced-pulmonary-inflammation
#8
Joshua B Lewis, Jared S Bodine, Jason R Gassman, Samuel Arce Muñoz, Dallin C Milner, Todd M Dunaway, Kaleb M Egbert, Troy D Monson, Dallin S Broberg, Juan A Arroyo, Paul R Reynolds
Claudin-6 (Cldn6) is a tetraspanin transmembrane protein that contributes to tight junctional complexes and has been implicated in the maintenance of lung epithelial barriers. In the present study, we tested the hypothesis that genetic up-regulation of Cldn-6 influences inflammation in mice exposed to short-term environmental diesel particulate matter (DPM). Mice were subjected to ten exposures of nebulized DPM (PM2.5) over a period of 20 days via a nose-only inhalation system (Scireq, Montreal, Canada). Using real-time RT-PCR, we discovered that the Cldn6 gene was up-regulated in control mice exposed to DPM and in lung-specific transgenic mice that up-regulate Cldn-6 (Cldn-6 TG)...
April 25, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29629708/dipyridamole-loaded-biodegradable-pla-nanoplatforms-as-coatings-for-cardiovascular-stents
#9
V Bakola, V Karagkiozaki, A R Tsiapla, F Pappa, I Moutsios, E Pavlidou, S Logothetidis
Cardiovascular stents are commonly used for the treatment of cardiovascular diseases that in developed societies are the most frequent causes of mortality and morbidity. In recent years, thorough research and development of drug-eluting stents has been done, with emphasis on coronary stenting to avoid the most common complication, in-stent thrombosis. Dipyridamole (DPM) is a medication that inhibits blood clot formation. Drug delivery nanoplatforms consisting of biodegradable polymers can be fabricated via electrospinning deposition, known for its cost-effective and versatile advantages, that produces fibrous scaffolds that are able to sustain and control drug release...
July 6, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29611137/taxonomic-description-and-genome-sequence-of-halobacillus-marinus-sp-nov-a-novel-strain-isolated-from-chilika-lake-india
#10
Ananta N Panda, Samir Ranjan Mishra, Lopamudra Ray, Surajit Das, Gurdeep Rastogi, Ajit Kumar Pattanaik, Tapan Kumar Adhya, Mrutyunjay Suar, Vishakha Raina
moderately halophilic spore forming, motile, Gram-positive, rod-shaped bacterial strain designated as KGW1T was isolated from water sample of Chilika Lake and characterized taxonomically using polyphasic approach. The strain grew in the presence of 0-25% (w/v) NaCl in marine salt agar media, hydrolyzes casein, and gelatin and shows presence of alkaline proteases. The major cell wall menaquinone was MK7 and major cellular fatty acids were anteiso-C15:0 (44.89%), anteiso-C17:0 (6.18%), isoC15:0 (19.38%), and iso-C16:0 (7...
April 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29608441/diesel-engine-exhaust-exposure-in-underground-mines-comparison-between-different-surrogates-of-particulate-exposure
#11
Alan da Silveira Fleck, Caroline Couture, Jean-François Sauvé, Pierre-Eric Njanga, Eve Neesham-Grenon, Guillaume Lachapelle, Hugo Coulombe, Stéphane Hallé, Simon Aubin, Jérôme Lavoué, Maximilien Debia
Exposure to diesel particulate matter (DPM) is frequently assessed by measuring indicators of carbon speciation, but these measurements may be affected by organic carbon (OC) interference. Furthermore, there are still questions regarding the reliability of direct-reading instruments (DRI) for measuring DPM, since these instruments are not specific and may be interfered by other aerosol sources. This study aimed to to assess DPM exposure in two underground mines by filter-based methods and DRI; and to assess the relationship between the measures of elemental carbon (EC) and the DRI to verify the association of these instruments to DPM...
April 2, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29534005/perceived-benefits-and-barriers-of-a-community-based-diabetes-prevention-and-management-program
#12
Samantha Shawley-Brzoska, Ranjita Misra
This study examined the perceptions of benefits of and barriers to participating in a community-based diabetes program to improve program effectiveness. The Diabetes Prevention and Management (DPM) program was a twenty-two session, 1-year program, modeled after the evidence-based National Diabetes Prevention Program and AADE7 Self-Care Behaviors framework. Community-based participatory research approach was used to culturally tailor the curriculum. Participants included overweight or obese adults with dysglycemia...
March 13, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29498616/marmoricola-silvestris-sp-nov-a-novel-actinobacterium-isolated-from-alpine-forest-soil
#13
Peter Schumann, De-Chao Zhang, Luís França, Rosa Margesin
A Gram-stain-positive, flagellated, catalase- and cytochrome c oxidase-positive bacterial strain, designated S20-100T , was isolated from alpine forest soil. Growth occurred at a temperature range of 0-30 °C, at pH 6-9 and in the presence of 0-1 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequence showed that strain S20-100T was related to the genus Marmoricola and had the highest 16S rRNA gene sequence similarity to Marmoricola ginsengisoli Gsoil 097T (98.4 %) and Marmoricola solisilvae KIS18-7T (98...
April 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29480870/the-clinical-effect-of-rehabilitation-following-arthroscopic-rotator-cuff-repair-a-meta-analysis-of-early-versus-delayed-passive-motion
#14
REVIEW
Shuxiang Li, Han Sun, Xiaomin Luo, Kun Wang, Guofeng Wu, Jian Zhou, Peng Wang, Xiaoliang Sun
BACKGROUND: The argument on the recommended rehabilitation protocol following arthroscopic rotator cuff repair remains to be resolved. So this meta-analysis was presented to evaluate the differences of clinical effects between the 2 distinct rehabilitation protocols after arthroscopic rotator cuff repair. METHODS: The PubMed, Cochrane Library, Web of Science, and EMBASE were systematically searched. Only randomized controlled trials (RCTs) published up to July 25, 2017, comparing early passive motion (EPM) versus delayed passive motion (DPM) rehabilitation protocols following arthroscopic rotator cuff repair were identified...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29478267/a-bayesian-nonparametric-approach-to-causal-inference-on-quantiles
#15
Dandan Xu, Michael J Daniels, Almut G Winterstein
We propose a Bayesian nonparametric approach (BNP) for causal inference on quantiles in the presence of many confounders. In particular, we define relevant causal quantities and specify BNP models to avoid bias from restrictive parametric assumptions. We first use Bayesian additive regression trees (BART) to model the propensity score and then construct the distribution of potential outcomes given the propensity score using a Dirichlet process mixture (DPM) of normals model. We thoroughly evaluate the operating characteristics of our approach and compare it to Bayesian and frequentist competitors...
February 25, 2018: Biometrics
https://www.readbyqxmd.com/read/29462356/nutrient-fortification-of-human-donor-milk-affects-intestinal-function-and-protein-metabolism-in-preterm-pigs
#16
Jing Sun, Yanqi Li, Duc Ninh Nguyen, Martin S Mortensen, Chris H P van den Akker, Tom Skeath, Susanne E Pors, Stanislava Pankratova, Silvia Rudloff, Søren J Sørensen, Douglas G Burrin, Thomas Thymann, Per T Sangild
Background: Nutrient fortification of human milk is often required to secure adequate growth and organ development for very preterm infants. There is concern that formula-based fortifiers (FFs) induce intestinal dysfunction, feeding intolerance, and necrotizing enterocolitis (NEC). Bovine colostrum (BC) may be an alternative nutrient fortifier, considering its high content of protein and milk bioactive factors. Objective: We investigated whether BC was superior to an FF product based on processed bovine milk and vegetable oil to fortify donor human milk (DHM) for preterm pigs, used as a model for infants...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29461816/photolytic-reactivity-of-organometallic-chromium-bipyridine-complexes
#17
Benjamin E Olafsen, Giuseppe V Crescenzo, Luke P Moisey, Brian O Patrick, Kevin M Smith
Known stable [Cr(bpy)2 (Ph)2 ](BPh4 ) complexes undergo reductive elimination of biphenyl with visible-light photolysis using household incandescent or compact fluorescent light bulbs. A series of [Cr(R-bpy)2 (Ar)2 ](X) complexes (R = H or CMe3 ; Ar = Ph, C6 H4 -CMe3 , or C6 H4 -OMe; X = I, BPh4 , or PF6 ) were prepared, and the effect of varying the bipyridine and aryl ligands on the UV-visible spectra and electrochemistry of the chromium(III) complexes was investigated. Photolysis of a mixture of two different bis(aryl) complexes gave only the homocoupled biaryl products by 1 H NMR and gas chromatography/mass spectrometry analysis...
February 20, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29455178/disabling-pansclerotic-morphoea-of-childhood
#18
Indirakshi Jamalpur, Harikrishna Reddy Mogili, Abhilash Koratala
Disabling pansclerotic morphoea (DPM) of childhood is a severe and often fatal variant of deep morphoea. It usually starts in childhood and rarely seen in adults. The course of the disease is progressive with lifelong morbidity in the form of joint contractures and immobility. The causes of mortality include complications such as sepsis, gangrene and cardiopulmonary involvement. Herein, we discuss the case of a 15-year-old girl with limb deformity and finger contractures, that is, bone involvement. The diagnosis of DPM of childhood was fortuitously made after the correction of limb deformity, when the patient was seen in the dermatology department for evaluation of skin discolouration on the thighs...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29431791/the-disclosure-of-mesoscale-behaviour-of-a-3d-smm-monolayer-on-au-111-through-a-multilevel-approach
#19
Guglielmo Fernandez Garcia, Alessandro Lunghi, Federico Totti, Roberta Sessoli
Here we present a computational study of a full- and a half-monolayer of a Fe4 single molecule magnet ([Fe4 (L)2 (dpm)6 ], where H3 L = 2-hydroxymethyl-2-phenylpropane-1,3-diol and Hdpm = dipivaloylmethane, Fe4 Ph) on an unreconstructed surface of Au(111). This has been possible through the application of an integrated approach, which allows the explicit inclusion of the packing effects in the classical dynamics to be used in a second step in periodic and non-periodic high level DFT calculations. In this way we can obtain access to mesoscale geometrical data and verify how they can influence the magnetic properties of interest of the single Fe4 molecule...
February 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29405794/assessment-of-lacrimal-resistance-using-a-manometric-tear-duct-irrigation-system
#20
Ebube E Obi, Oyinkan Olurin, Peter M Mota, Zuzana Sipkova, Oana Vonica, Andrew R Pearson
Lacrimal surgery aims to provide a low-resistance tear drainage passage. An assessment of lacrimal resistance guides decisions on surgery. We present results of a modified tear duct irrigation system that reliably measures lacrimal outflow resistance. Patients in a specialist lacrimal clinic had a full work-up to the point of tear duct syringing. The tear ducts were irrigated using a manometric system, which applied a fixed, known head of fluid pressure to a lacrimal cannula. Fluid flow is recorded and the lacrimal resistance derived as fluid pressure/fluid flow (units cmH20 secml-1, for simplicity presented as drops per minute, dpm)...
February 6, 2018: Orbit
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