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Daniel Hausmann, Cristina Zulian, Edouard Battegay, Lukas Zimmerli
BACKGROUND: Decision-making processes in a medical setting are complex, dynamic and under time pressure, often with serious consequences for a patient's condition. OBJECTIVE: The principal aim of the present study was to trace and map the individual diagnostic process of real medical cases using a Decision Process Matrix [DPM]). METHODS: The naturalistic decision-making process of 11 residents and a total of 55 medical cases were recorded in an emergency department, and a DPM was drawn up according to a semi-structured technique following four steps: 1) observing and recording relevant information throughout the entire diagnostic process, 2) assessing options in terms of suspected diagnoses, 3) drawing up an initial version of the DPM, and 4) verifying the DPM, while adding the confidence ratings...
October 18, 2016: BMC Medical Informatics and Decision Making
Sara Vidal, Marta Izquierdo, Wai Kit Law, Kui Jiang, Salvatore Filippone, Josefina Perles, He Yan, Nazario Martín
Methanofullerenes such as the well-known [70]PCBM are commonly synthesized under harsh conditions to obtain the product as a mixture of site-isomers (namely α, β and minor γ) due to the D5h symmetry of the C70 cage. We report the first site-selective synthesis of [70]methanofullerenes under light irradiation and low temperatures, thus avoiding time-consuming and highly expensive HPLC separations. Pure major site-isomers α-[70]PCBM and α-[70]DPM have been thus efficiently prepared including the crystal structure of 5b...
October 10, 2016: Chemical Communications: Chem Comm
K Suzuki, G Michael, Y Tamire
OBJECTIVE: Advances in wound treatment have yielded successful approaches to complex wound closure through plastic surgery or other staged surgical methods. However, not all patients or wounds are candidates for such increasingly rigorous levels of interventions. The exploration of non-surgical treatment options that promote anatomical and functional tissue replacement on an outpatient basis without donor site morbidity is necessary to maximise opportunities for patient mobility and rehabilitation...
October 2016: Journal of Wound Care
Yongqiu Xia, Donald E Weller, Meghan N Williams, Thomas E Jordan, Xiaoyuan Yan
Export coefficient models (ECMs) are often used to predict nutrient sources and sinks in watersheds because ECMs can flexibly incorporate processes and have minimal data requirements. However, ECMs do not quantify uncertainties in model structure, parameters, or predictions; nor do they account for spatial and temporal variability in land characteristics, weather, and management practices. We applied Bayesian hierarchical methods to address these problems in ECMs used to predict nitrate concentration in streams...
November 15, 2016: Water Research
Oriane Turrel, Aurélie Lampin-Saint-Amaux, Thomas Préat, Valérie Goguel
UNLABELLED: Neprilysins are type II metalloproteinases known to degrade and inactivate a number of small peptides. Neprilysins in particular are the major amyloid-β peptide-degrading enzymes. In mouse models of Alzheimer's disease, neprilysin overexpression improves learning and memory deficits, whereas neprilysin deficiency aggravates the behavioral phenotypes. However, whether these enzymes are involved in memory in nonpathological conditions is an open question. Drosophila melanogaster is a well suited model system with which to address this issue...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Konstantinos Koutroumpas, Paolo Ballarini, Irene Votsi, Paul-Henry Cournède
MOTIVATION: Likelihood-free methods, like Approximate Bayesian Computation (ABC), have been extensively used in model-based statistical inference with intractable likelihood functions. When combined with Sequential Monte Carlo (SMC) algorithms they constitute a powerful approach for parameter estimation and model selection of mathematical models of complex biological systems. A crucial step in the ABC-SMC algorithms, significantly affecting their performance, is the propagation of a set of parameter vectors through a sequence of intermediate distributions using Markov kernels...
September 1, 2016: Bioinformatics
Jean Claude Reubi, Beatrice Waser, Helmut R Maecke, Jean E Rivier
: There is recent in vitro and in vivo evidence that somatostatin receptor sst2 antagonists are better tools to target neuroendocrine tumors (NET) than sst2 agonists. Indeed, antagonists bind to a greater number of sst2 sites than agonists. Whether sst2 antagonists could be used successfully to target non-NET tumors, expressing low sst2 density, is unknown. Here, we compare quantitatively (125)I-JR11 sst2 antagonist binding in vitro with that of the sst2 agonist (125)I-Tyr3-octreotide in large varieties of non-NET and NET...
August 25, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
V L Newton, R S Bradley, P Seroul, M Cherel, C E M Griffiths, A V Rawlings, R Voegeli, R E B Watson, M J Sherratt
BACKGROUND/PURPOSE: The dermal-epidermal junction (DEJ) forms epidermal protrusions down into the dermis (rete ridges) and dermal projections up into the epidermis (dermal papillae). Usually visualized in two-dimensions (2D), our knowledge of how the DEJ changes with ageing is limited. We aimed to characterize how this structure exists in 3D and changes with age. METHODS: Photoprotected and photoexposed skin were imaged using reflectance confocal microscopy (RCM) in young and aged individuals...
August 9, 2016: Skin Research and Technology
Yasuaki Tokudome, Megu Fukui, Naoki Tarutani, Sari Nishimura, Vanessa Prevot, Claude Forano, Gowsihan Poologasundarampillai, Peter D Lee, Masahide Takahashi
Hierarchically porous biocompatible Mg-Al-Cl-type layered double hydroxide (LDH) composites containing aluminum hydroxide (Alhy) have been prepared using a phase-separation process. The sol-gel synthesis allows for the hierarchical pores of the LDH-Alhy composites to be tuned, leading to a high specific solid surface area per unit volume available for high-molecular-weight protein adsorptions. A linear relationship between the effective surface area, SEFF, and loading capacity of a model protein, bovine serum albumin (BSA), is established following successful control of the structure of the LDH-Alhy composite...
September 6, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Jonathan Lombard
BACKGROUND: The N-glycosylation is an essential protein modification taking place in the membranes of the endoplasmic reticulum (ER) in eukaryotes and the plasma membranes in archaea. It shares mechanistic similarities based on the use of polyisoprenol lipid carriers with other glycosylation pathways involved in the synthesis of bacterial cell wall components (e.g. peptidoglycan and teichoic acids). Here, a phylogenomic analysis was carried out to examine the validity of rival hypotheses suggesting alternative archaeal or bacterial origins to the eukaryotic N-glycosylation pathway...
2016: Biology Direct
Scott E Davidson, Jing Cui, Stephen Kry, Joseph O Deasy, Geoffrey S Ibbott, Milos Vicic, R Allen White, David S Followill
PURPOSE: A dose calculation tool, which combines the accuracy of the dose planning method (DPM) Monte Carlo code and the versatility of a practical analytical multisource model, which was previously reported has been improved and validated for the Varian 6 and 10 MV linear accelerators (linacs). The calculation tool can be used to calculate doses in advanced clinical application studies. One shortcoming of current clinical trials that report dose from patient plans is the lack of a standardized dose calculation methodology...
August 2016: Medical Physics
L Tesi, A Lunghi, M Atzori, E Lucaccini, L Sorace, F Totti, R Sessoli
Vanadium(iv) complexes have recently shown record quantum spin coherence times that in several circumstances are limited by spin-lattice relaxation. The role of the environment and vibronic properties in the low temperature dynamics is here investigated by a comparative study of the magnetization dynamics as a function of crystallite size and the steric hindrance of the β-diketonate ligands in VO(acac)2 (1), VO(dpm)2 (2) and VO(dbm)2 (3) evaporable complexes (acac(-) = acetylacetonate, dpm(-) = dipivaloylmethanate, and dbm(-) = dibenzoylmethanate)...
August 3, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Juma Obayashi, Kunihide Tanaka, Kei Ohyama, Shutaro Manabe, Hideki Nagae, Hideki Shima, Hideaki Sato, Shigeyuki Furuta, Munechika Wakisaka, Junki Koike, Masayuki Takagi, Hiroaki Kitagawa
BACKGROUND: There is no good prognostic indicator for biliary atresia (BA). We reviewed liver biopsies taken during the initial procedure to find a prognostic marker. METHODS: Thirty-two BA cases underwent Kasai operation from 1976 to 2009. We compared two groups at 1, 3, and 9 years. Group A required liver transplantation or died. Group B survived with their native liver. Biopsies were analyzed for liver fibrosis, portal-central vein bridging (P-C bridging), ductal plate malformation (DPM) and the number of the bile ducts in portal canal/measured surface area of the portal canal (BDP ratio)...
September 2016: Pediatric Surgery International
Nawel Khaldi, Yoldoss Chouari, Hatem Mhiri, Philippe Bournot
A series of numerical simulations are performed to study the pollutant and sediment transport in free surface channel flow. The present paper examines the dispersion of passive contaminants injected from a time periodic source in a fully developed turbulent flow. More precisely, the pulsation effects on the distribution behaviors of dissolved and particulate pollutants are analyzed and discussed. Simulations are carried out using a commercial Computational Fluid Dynamic (CFD) code, Fluent 6.3, which is based on the finite volume approach...
July 13, 2016: Environmental Pollution
Youngmin Kim, Ki-Seong Lee, Ngoc-Son Pham, Sun-Ro Lee, Chan-Gun Lee
Energy efficiency is considered as a critical requirement for wireless sensor networks. As more wireless sensor nodes are equipped with multi-cores, there are emerging needs for energy-efficient real-time scheduling algorithms. The T-L plane-based scheme is known to be an optimal global scheduling technique for periodic real-time tasks on multi-cores. Unfortunately, there has been a scarcity of studies on extending T-L plane-based scheduling algorithms to exploit energy-saving techniques. In this paper, we propose a new T-L plane-based algorithm enabling energy-efficient real-time scheduling on multi-core sensor nodes with dynamic power management (DPM)...
2016: Sensors
Shrawan Baghel, Helen Cathcart, Niall J O'Reilly
Amorphous solid dispersions (ASDs) have the potential to offer higher apparent solubility and bioavailability of BCS class II drugs. Knowledge of the solid state drug-polymer solubility/miscibility and their mutual interaction are fundamental requirements for the effective design and development of such systems. To this end, we have carried out a comprehensive investigation of various ASD systems of dipyridamole and cinnarizine in polyvinylpyrrolidone (PVP) and polyacrylic acid (PAA) at different drug loadings...
October 2016: European Journal of Pharmaceutics and Biopharmaceutics
Luca Rigamonti, Carri Cotton, Andrea Nava, Heinrich Lang, Tobias Rüffer, Mauro Perfetti, Lorenzo Sorace, Anne-Laure Barra, Yanhua Lan, Wolfgang Wernsdorfer, Roberta Sessoli, Andrea Cornia
A 3D metal-organic framework (MOF) having single-molecule magnet (SMM) linkers was prepared in crystalline form by using a tetrairon(III) complex functionalised with two divergent pyridyl groups, namely [Fe4 (pPy)2 (dpm)6 ] (1; H3 pPy=2-(hydroxymethyl)-2-(pyridin-4-yl)propane-1,3-diol, Hdpm=dipivaloylmethane). Reaction of 1 with silver(I) perchlorate afforded {[Fe4 (pPy)2 (dpm)6 ]2 Ag}ClO4 (2), which crystallises in a cubic face-centred lattice and exhibits two interlocked diamondoid networks. In 2, the SMMs act as linear ditopic synthons, and silver(I) ions as tetrahedral nodes coordinated by four pyridyl nitrogen atoms...
September 12, 2016: Chemistry: a European Journal
Maria Marchese, Andrea Pappalardo, Jacopo Baldacci, Tiziano Verri, Stefano Doccini, Denise Cassandrini, Claudio Bruno, Chiara Fiorillo, Mercedes Garcia-Gil, Enrico Bertini, Letizia Pitto, Filippo M Santorelli
Defective dolichol-phosphate mannose synthase (DPMS) complex is a rare cause of congenital muscular dystrophy associated with hypoglycosylation of alpha-dystroglycan (α-DG) in skeletal muscle. We used the zebrafish (Danio rerio) to model muscle abnormalities due to defects in the subunits of DPMS. The three zebrafish ortholog subunits (encoded by the dpm1, dpm2 and dpm3 genes, respectively) showed high similarity to the human proteins, and their expression displayed localization in the midbrain/hindbrain area and somites...
August 12, 2016: Biochemical and Biophysical Research Communications
Su-Yang Yao, Yan-Ling Ou, Bao-Hui Ye
Chiral precursors Λ-[Ir(ppy)2(l-pro)] (Λ-L, where ppy is 2-phenylpyridine; pro is proline), Λ-[Ir(ppy)2(MeCN)2](PF6) (Λ-1), Δ-[Ir(ppy)2(d-pro)] (Δ-D), and Δ-[Ir(ppy)2(MeCN)2](PF6) (Δ-1) were synthesized from rac-[(Ir(ppy)2)2Cl2] and l-pro or d-pro by means of the auxiliary ligand strategy with 99% de values. The enantiopure mono complexes Λ/Δ-[Ir(ppy)2(L)](PF6) (L is 2,2'-bipyridine, Λ/Δ-2; L is 2,2'-dipyrimidine (dpm), Λ/Δ-3; L is 2,2'-bibenzimidazole (H2bbim), Λ/Δ-4) with 99% ee values and binuclear complexes ΛΛ/ΔΔ-[(Ir(ppy)2)2(dpm)](PF6)2 (ΛΛ-5 and ΔΔ-5) and ΛΛ/ΔΔ-[(Ir(ppy)2)2(bbim)] (ΛΛ-6 and ΔΔ-6) with 99% de values were synthesized in one step using the corresponding chiral precursors...
June 20, 2016: Inorganic Chemistry
Chaoxian Zhang, Like Guo, Yongmei Qin, Guangyan Li
OBJECTIVE: To investigate the correlation between Helicobacter pylori (H. Pylori) infection and polymorphism of adiponectin gene promoter -11391G/A, extracellular superoxide dismutase (EC-SOD) gene in nonalcoholic fatty liver disease (NAFLD).
 METHODS: From June, 2010 to July, 2014, a hospital-based 1:1 matched case-control study was carried out, with 600 cases of NAFLD and 600 healthy people in the First Affiliated Hospital of Xinxiang Medical University. The genetic polymorphisms of adiponectin gene promoter -11391G/A and EC-SOD were analyzed by polymorphism-polymerase chain reaction (PCR) technique in peripheral blood leukocytes of the subjects...
April 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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