keyword
https://read.qxmd.com/read/37301957/high-tibial-osteotomy-for-acute-correction-and-subsequent-gradual-tensioning-of-the-posterolateral-knee-ligament-complex-in-treating-genu-varum-combined-with-a-lateral-thrust-using-the-ilizarov-technique-in-adults-surgical-technique-and-early-results
#21
JOURNAL ARTICLE
Mohamed Abdelaal Hussein, Ahmed A Khalifa, Gamal Ahmed Hosny
OBJECTIVE: To report the early results of using the Ilizarov technique in performing medial wedge opening high tibial osteotomy (MWOHTO) combined with gradual tensioning of the posterolateral corner in adult patients presenting with genu varum (GV) and lateral thrust. METHODS: A prospective case series study included 12 adult patients with a mean age of 25.2 ± 8.1 years who presented with GV deformity associated with lateral thrust. They were evaluated clinically using the "hospital for special surgery" (HSS) knee scoring system...
June 10, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/37280669/achondroplasia-natural-history-study-clarity-60-year-experience-in-orthopedic-surgery-from-four-skeletal-dysplasia-centers
#22
JOURNAL ARTICLE
Nickolas J Nahm, W G Stuart Mackenzie, William G Mackenzie, Ethan Gough, S Shahrukh Hashmi, Jacqueline T Hecht, Janet M Legare, Mary Ellen Little, Peggy Modaff, Richard M Pauli, David F Rodriguez-Buritica, Maria Elena Serna, Cory J Smid, Julie Hoover-Fong, Michael B Bober
BACKGROUND: The purpose of this study was to describe the frequency and risk factors for orthopedic surgery in patients with achondroplasia. CLARITY (The Achondroplasia Natural History Study) includes clinical data from achondroplasia patients receiving treatment at four skeletal dysplasia centers in the United States from 1957 to 2018. Data were entered and stored in a Research Electronic Data Capture (REDCap) database. RESULTS: Information from one thousand three hundred and seventy-four patients with achondroplasia were included in this study...
June 6, 2023: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/37253708/hemiepiphysiodesis-for-lower-extremity-coronal-plane-angular-correction-in-the-distal-femur-and-proximal-tibia-in-children-with-achondroplasia
#23
JOURNAL ARTICLE
Christopher A Makarewich, Emily Zhang, Peter M Stevens
BACKGROUND: Achondroplasia is the most prevalent form of skeletal dysplasia, affecting more than 250,000 individuals. Lower extremity angular deformities, particularly genu varum, are common in children with achondroplasia, often resulting in pain and limitation of function. The authors aim to determine the utility of lower extremity growth modulation with hemiepiphysiodesis in children with achondroplasia for correction of coronal plane deformities about the knee. METHODS: The authors performed a retrospective chart review of a single center from 1/1/2000 to 12/31/2020 to identify pediatric patients with achondroplasia treated with hemiepiphysiodesis as their initial procedure at the distal femur and/or proximal tibia...
May 29, 2023: Journal of Pediatric Orthopedics
https://read.qxmd.com/read/37214758/variant-of-the-catalytic-cysteine-of-ufsp2-leads-to-spondyloepimetaphyseal-dysplasia-type-di-rocco
#24
Larissa Mattern, Matthias Begemann, Heide Delbrück, Petra Holschbach, Silvia Schröder, Sabine M Schacht, Ingo Kurth, Miriam Elbracht
Spondyloepimetaphyseal dysplasia (SEMD) is characterized by vertebral, epiphyseal, and metaphyseal alterations. Patients become predominantly apparent with disproportionate short stature. The genetic background of SEMD is heterogeneous, with different modes of inheritance (autosomal dominant, autosomal recessive, and X-linked disorders). Amongst the genes in which variants are known to cause SEMD, UFM1-specific protease 2 ( UFSP2 ) encodes a cysteine protease involved in the maturation of Ubiquitin-fold modifier 1 (UFM1)...
June 2023: Bone Reports
https://read.qxmd.com/read/37205724/treatment-of-angular-deformity-and-limb-length-discrepancy-with-a-retrograde-femur-magnetic-intramedullary-nail-a-fixator-assisted-blocking-screw-technique
#25
JOURNAL ARTICLE
Erik J Geiger, Adam D Geffner, S Robert Rozbruch, Austin T Fragomen
BACKGROUND: Fixator-assisted nailing techniques that incorporate magnetic internal lengthening nails (MILNs) permit acute deformity correction and then gradual limb lengthening without needing postoperative external fixators. PURPOSES: We sought to investigate the safety and accuracy of a fixator-assisted, blocking screw technique using retrograde MILNs for the correction of LLD and limb malalignment. METHODS: Forty-one patients (13 patients with genu varum and 28 patients with genu valgum) with LLD treated with fixator-assisted, blocking screw retrograde MILN reconstruction were included...
May 1, 2023: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
https://read.qxmd.com/read/36874732/a-systematic-review-on-quadriceps-angle-in-relation-to-knee-abnormalities
#26
REVIEW
Rahul Sharma, Vikas Vaibhav, Raviprakash Meshram, Brijendra Singh, Gitanjali Khorwal
Previous studies on the quadriceps (Q) angle and its relation to knee problems have led to conflicting conclusions. In this comprehensive review, we evaluate recent studies on the Q angle and analyze the changes in Q angles. Specifically, we investigate the variation in Q angles when measured under the following conditions: 1) under various measurement techniques; 2) between symptomatic and non-symptomatic groups; 3) between samples of men and women; 4) unilateral versus bilateral Q angles; 5) Q angle in adolescent boys and girls...
January 2023: Curēus
https://read.qxmd.com/read/36854319/guided-growth-angular-deformity-correction-through-temporary-hemiepiphysiodesis-with-a-novel-flexible-staple-flextack
#27
JOURNAL ARTICLE
Bjoern Vogt, Gregor Toporowski, Georg Gosheger, Andrea Laufer, Adrien Frommer, Marie-Theres Kleine-Koenig, Robert Roedl, Carina Antfang
Temporary hemiepiphysiodesis (HED) is applied to children and adolescents to correct angular deformities (ADs) in long bones through guided growth. Traditional Blount staples or two-hole plates are mainly used for this indication. Despite precise surgical techniques and attentive postoperative follow-up, implant-associated complications are frequently described. To address these pitfalls, a flexible staple was developed to combine the advantages of the established implants. This study provides the first results of guided growth using the new implant and compares these with the established two-hole plates and Blount staples...
March 1, 2023: Bone & Joint Journal
https://read.qxmd.com/read/36832505/single-stage-tibial-osteotomy-for-correction-of-genu-varum-deformity-in-children
#28
JOURNAL ARTICLE
Nikolas Kolbe, Frank Haydon, Johannes Kolbe, Thomas Dreher
Conservative and operative treatments with gradual or acute correction of severe varus deformities of the leg have been described. We evaluated whether the corrective osteotomy used within the NGO Mercy Ships is an effective treatment for genu varum deformity of different etiologies in children and which patient specific factors have an influence on the radiographic outcome. In total, 208 tibial valgisation osteotomies were performed in 124 patients between 2013 and 2017. The patients' mean age at the time of surgery was 8...
February 14, 2023: Children
https://read.qxmd.com/read/36647862/incidence-of-adductor-tubercle-tendinitis-and-its-effect-on-clinical-results-in-patients-with-genu-varum-undergoing-high-tibial-osteotomy
#29
JOURNAL ARTICLE
A Bedrettin, Y Mucahid Osman
OBJECTIVE: This study aims to investigate the incidence of adductor tubercle tendinitis (ATT) and demonstrate the effects of intraoperative steroid injections on clinical outcomes in patients undergoing high tibial osteotomy (HTO) due to genu varum (GV). PATIENTS AND METHODS: Of 738 patients who underwent HTO due to GV between 2014-2021, 454 patients had accompanying preoperative ATT. Of these patients, 324 patients who presented to follow-ups and had adequate medical records were evaluated...
January 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/36611582/effect-of-combined-exercise-program-on-lower-extremity-alignment-and-knee-pain-in-patients-with-genu-varum
#30
JOURNAL ARTICLE
Hyung-Hoon Moon, Yong-Gon Seo, Won-Moon Kim, Jae-Ho Yu, Hae-Lim Lee, Yun-Jin Park
This study aimed to assess the effect of a combined exercise program on lower-extremity alignment and knee pain in patients with genu varum. Forty-seven middle-aged women with knee pain and genu varum were randomly divided into the exercise (EG, n = 24) and control (CG, n = 23) groups. The exercise group underwent a combined exercise program lasting 60 min in one session, three times a week for 12 weeks. Knee-to-knee length (KTKL), hip-knee-ankle angle (HKAA), hip inclination angle (HIA), and medial proximal tibial angle (MPTA) were assessed to evaluate lower-extremity alignment...
December 30, 2022: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/36583511/growth-modulation-by-tension-band-plate-in-achondroplasia-with-varus-knee-deformity-comparison-of-gait-analysis-measurements
#31
JOURNAL ARTICLE
Armagan C Ulusaloglu, Ali Asma, Luiz C Silva, Freeman Miller, William G Mackenzie, W G Stuart Mackenzie
BACKGROUND: Limited evidence exists concerning growth modulation by tension band plate (TBP) to correct varus deformity in patients with achondroplasia with limited growth due to FGFR3 gene mutation. We evaluated the efficacy of TBP in children with achondroplasia with genu varum and reported the static radiographic and dynamic motion data to determine parameters that impact the rate of deformity correction. METHODS: Patients with achondroplasia with genu varum who underwent TBP surgery for growth modulation were studied...
March 1, 2023: Journal of Pediatric Orthopedics
https://read.qxmd.com/read/36556271/virtual-surgical-planning-3d-printing-and-customized-bone-allograft-for-acute-correction-of-severe-genu-varum-in-children
#32
Giulia Alessandri, Leonardo Frizziero, Gian Maria Santi, Alfredo Liverani, Dante Dallari, Leonardo Vivarelli, Giovanni Luigi Di Gennaro, Diego Antonioli, Grazia Chiara Menozzi, Alessandro Depaoli, Gino Rocca, Giovanni Trisolino
Complex deformities of lower limbs are frequent in children with genetic or metabolic skeletal disorders. Early correction is frequently required, but it is technically difficult and burdened by complications and recurrence. Herein, we described the case of a 7-year-old girl affected by severe bilateral genu varum due to spondyloepiphyseal dysplasia. The patient was treated by patient-specific osteotomies and customized structural wedge allograft using Virtual Surgical Planning (VSP) and 3D-printed patient-specific instrumentation (PSI)...
December 12, 2022: Journal of Personalized Medicine
https://read.qxmd.com/read/36442838/clinical-manifestations-and-outcomes-of-20-korean-hypochondroplasia-patients-with-the-fgfr3-n540k-variant
#33
JOURNAL ARTICLE
Hwa Young Kim, Young Ah Lee, Choong Ho Shin, Tae-Joon Cho, Jung Min Ko
BACKGROUND: Hypochondroplasia is a skeletal dysplasia caused by activating pathologic variants of FGFR3. The N540K variant accounts for 60%-70% of reported cases and is associated with severe manifestations. Here, we analyzed the clinical manifestations and outcomes of Korean patients with hypochondroplasia harboring the FGFR3 N540K variant. METHODS: Medical records of 20 unrelated patients with genetically confirmed N540K-related hypochondroplasia were retrospectively reviewed...
November 28, 2022: Experimental and Clinical Endocrinology & Diabetes
https://read.qxmd.com/read/36334264/the-first-compound-heterozygous-mutations-of-dmp1-causing-rare-autosomal-recessive-hypophosphatemic-rickets-type-1
#34
JOURNAL ARTICLE
Xiaolin Ni, Yiyi Gong, Yan Jiang, Xiang Li, Qianqian Pang, Wei Liu, Yue Chi, Ruizhi Jiajue, Ou Wang, Mei Li, Xiaoping Xing, Weibo Xia
CONTEXT: Hereditary hypophosphatemic rickets (HR) consists of a group of inherited hypophosphatemia due to mutations of different genes, which needs genetic analysis to make differential diagnosis. Among them, autosomal recessive hypophosphatemic rickets type 1 (ARHR1) caused by homozygous mutation of dentin matrix protein 1 (DMP1), is extremely rare only with 30 reported patients. To date, there has been no case with compound heterozygous DMP1 mutations. OBJECTIVES, DESIGN, SETTING AND PARTICIPANTS: In this study, we reported the clinical features of a Chinese patient with HR...
November 5, 2022: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/36292236/influence-of-medial-osteotomy-height-and-hinge-position-in-open-wedge-high-tibial-osteotomy-a-simulation-study
#35
JOURNAL ARTICLE
Grégoire Thürig, Alexander Korthaus, Jannik Frings, Markus Thomas Berninger, Karl-Heinz Frosch, Matthias Krause
(1) Background: In treating medial unicompartmental gonarthrosis, medial open wedge high tibial osteotomy (mOWHTO) reduces pain and is intended to delay a possible indication for joint replacement by relieving the affected compartment. This study aimed to investigate the influence of the osteotomy height with different hinge points in HTO in genu varum on the leg axis. (2) Methods: Fifty-five patients with varus lower leg alignment obtained full-weight bearing long-leg radiographs were analyzed. Different simulations were performed: Osteotomy height was selected at 3 and 4 cm distal to the tibial articular surface, and the hinge points were selected at 0...
October 20, 2022: Diagnostics
https://read.qxmd.com/read/36261652/evaluation-of-volumetric-bone-mineral-density-bone-microarchitecture-and-bone-strength-in-patients-with-achondroplasia-caused-by-fgfr3-c-1138g-a-mutation
#36
JOURNAL ARTICLE
Hanting Liang, Wenting Qi, Chenxi Jin, Qianqian Pang, Wei Liu, Yan Jiang, Ou Wang, Mei Li, Xiaoping Xing, Hui Pan, Weibo Xia
Achondroplasia (ACH) is a skeletal disorder caused by fibroblast growth factor receptor 3 (FGFR3) variants. Volumetric bone mineral density (vBMD), bone microarchitecture, and strength have not been evaluated in these patients previously. This study aims to evaluate vBMD, bone microarchitecture, and strength in ACH patients. Seventeen patients underwent clinical and biochemical evaluations, and genetic testing. High-resolution peripheral quantitative computed tomography was performed in 10 ACH patients and 21 age- and sex-matched healthy subjects...
October 19, 2022: Calcified Tissue International
https://read.qxmd.com/read/36196622/coronal-plane-leg-alignment-in-adolescence-and-the-effects-of-activity-a-full-leg-length-mri-study
#37
JOURNAL ARTICLE
Scott Fernquest, Thomas Lloyd, Claudio Pereira, Mo Gimpel, Richard Birchall, John Broomfield, Sion Glyn-Jones, Antony Palmer
The aim of this study was to explore the association between developing coronal-plane leg alignment and activity levels during adolescence. We performed a cross-sectional cohort study with individuals from soccer club academies and an age-matched control population. Outcome measures were the hip knee angle (HKA), medial proximal tibial physeal angle (MPTPhyA), lateral distal femoral physeal angle (LDFPhyA) on full leg length magnetic reasonance imagine scans, and the physical activity questionnaire (PAQ) score...
October 5, 2022: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/36108819/correction-of-pediatric-angular-deformities-in-lower-limbs-through-guided-growth-using-a-novel-flexible-plate-system
#38
JOURNAL ARTICLE
Daniel Quintero, Miguel Galbán, Cesar Gil
INTRODUCTION: Tension band plates (TBP) for guided growth (GG) are the gold standard treatment for angular deformities around the knee. EPIFLEX® is a novel flexible TBP that adjusts to the patient's bone anatomy. HYPOTHESIS: GG using a flexible TBP produces satisfactory correction rates with minor complications in the pediatric population with angular deformities around the knee. MATERIALS AND METHODS: A retrospective evaluation of 33 patients (60 knees) treated for genu varum and valgum with hemiepiphysiodesis using a flexible TBP between 2017 and 2020 was performed...
May 2023: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/36098615/patellofemoral-joint-after-opening-wedge-high-tibial-osteotomy-a-comparative-study-of-uniplane-versus-biplane-osteotomies
#39
JOURNAL ARTICLE
Yi Zheng, Zhijie Wang, Hongzhi Lv, Jinbo Li, Runqi Zhuo, Juan Wang
OBJECTIVE: To the best of our knowledge, there has been no comparative study of changes in radiographic parameters in the sagittal plane between biplane opening wedge high tibial osteotomy (OWHTO) with plate fixation and uniplane OWHTO with spacer implantation. The aim of the study was to compare sagittal radiographs between the procedures of biplane and uniplane OWHTOs in patients with genu varum and to investigate the impact on the patellofemoral joint. METHODS: A retrospective study of 71 patients (58...
September 13, 2022: Orthopaedic Surgery
https://read.qxmd.com/read/36087834/double-level-osteotomy-for-genu-varum-is-a-return-to-sport-possible
#40
JOURNAL ARTICLE
Alexandre Caubere, Olivier Barbier, Kristian Kley, Lukas Hanak, Christophe Jacquet, Matthieu Ollivier
INTRODUCTION: A double level osteotomy (DLO) may be indicated in patients with genu varum when the deformity involves both the tibia and femur. These patients, who are often young and active, have a high functional demand and hope for a rapid return to sport. The purpose of our study was to assess return to sport and functional outcomes following DLO for symptomatic genu varum. MATERIALS AND METHODS: A total of 40 patients (mean age 45.5 ± 2 years) who underwent a DLO between 2018 and 2020, performed in 2 different hospitals, were reviewed after a minimum follow-up of 1-year...
September 7, 2022: Orthopaedics & Traumatology, Surgery & Research: OTSR
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