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Ayush Attery, Punyatirtha Dey, Prajna Tripathi, Janendra K Batra
Human pancreatic ribonuclease (HPR) and bovine seminal ribonuclease (BS-RNase) are members of the RNase A superfamily. HPR is monomeric, whereas BS-RNase is dimeric. BS-RNase has strong antitumor and cytotoxic activities. However, HPR lacks cytotoxic activity as it is inactivated by intracellular cytosolic ribonuclease inhibitor (RI). Earlier, an RI-resistant cytotoxic variant of HPR, termed HPR-KNE was generated which contained three residues Lys7, Asn71 and Glu111 of HPR, known to interact with RI, mutated to alanine...
February 2018: International Journal of Biological Macromolecules
P Y Iroh Tam, B Krzyzanowski, J M Oakes, L Kne, S Manson
Fine resolution spatial variability in pneumonia hospitalization may identify correlates with socioeconomic, demographic and environmental factors. We performed a retrospective study within the Fairview Health System network of Minnesota. Patients 2 months of age and older hospitalized with pneumonia between 2011 and 2015 were geocoded to their census block group, and pneumonia hospitalization risk was analyzed in relation to socioeconomic, demographic and environmental factors. Spatial analyses were performed using Esri's ArcGIS software, and multivariate Poisson regression was used...
November 2017: Epidemiology and Infection
Alyssa Kne, Heather Zierhut, Shari Baldinger, Karen K Swenson, Pamela Mink, Patricia McCarthy Veach, Michaela L Tsai
Family history information comprises an important tool in identifying and referring patients at risk for hereditary breast and ovarian cancer (HBOC) to cancer genetic counseling. Despite recommendations and support provided by numerous professional organizations, cancer genetic counseling services are underutilized by atrisk patients. This study aimed to: (1) determine the rate of genetic counseling utilization following a referral letter, (2) characterize factors (barriers and supports) which influenced uptake of services, and (3) identify potential strategies for increasing utilization...
August 2017: Journal of Genetic Counseling
Kodjovi Agbodeka, Holaly E Gbekley, Simplice D Karou, Kokou Anani, Amegnona Agbonon, Tchadjobo Tchacondo, Komlan Batawila, Jacques Simpore, Messanvi Gbeassor
BACKGROUND: In Togo, malaria constitutes a major public health problem but, until now, the population still mostly relies on herbal medicine for healing. This study aimed to document medicinal plants used for malaria therapy in the Plateau region of the country. METHODOLOGY: Semi-structured questionnaire interviews were used to gather ethnobotanical and sociodemographic data from traditional healers of the study area. RESULTS: A total of 61 plants species belonging to 33 families were found to be in use for malaria therapy in the Plateau region...
March 2016: Pharmacognosy Research
Małgorzata Drywień, Joanna Frąckiewicz, Magdalena Górnicka, Joanna Gadek, Małgorzata Jałosińska
BACKGROUND: Fermented milk drinks are unique products due to content of Lactobacillus and Bifidobacterium that are recognized as probiotics. They are a natural component of the colon microbiota as well as commonly used probiotics in functional food. OBJECTIVES: The effects of the storage time and prebiotic type (inuline or oligofructose) were studied in banana-milk drink after fermentation by Lactobacillus casei KNE-1 on the thiamine and riboflavin concentrations...
2015: Roczniki Państwowego Zakładu Higieny
Sungahn Ko, Jieqiong Zhao, Jing Xia, Shehzad Afzal, Xiaoyu Wang, Greg Abram, Niklas Elmqvist, Len Kne, David Van Riper, Kelly Gaither, Shaun Kennedy, William Tolone, William Ribarsky, David S Ebert
We present VASA, a visual analytics platform consisting of a desktop application, a component model, and a suite of distributed simulation components for modeling the impact of societal threats such as weather, food contamination, and traffic on critical infrastructure such as supply chains, road networks, and power grids. Each component encapsulates a high-fidelity simulation model that together form an asynchronous simulation pipeline: a system of systems of individual simulations with a common data and parameter exchange format...
December 2014: IEEE Transactions on Visualization and Computer Graphics
Aidas Saldaitis, Oleg Pekarsky
A new tiger moth, Micrarctia kautti sp. n., from southwest China, Sichuan is described. A diagnostic comparison with Micrarctia trigona (Leech, 1899) is provided. During recent years the Chinese Arctiini have been intensively collected and explored (Dubatolov, 1996a; Dubatolov, 1996b; Dubatolov, 2003; Dubatolov, Kishida & Wu, 2005; Fang & Cao, 1984; Fang, 2000 and numerous other publications) so the discovery of a striking new species by Sergey Murzin in the Dafengding Mountains, Sichuan Province, was most unexpected...
May 4, 2015: Zootaxa
Xiuxiu Li, Zhen Sun, Xiaojie Xu, Wen-Xue Li, Cheng Zou, Shanhong Wang, Yunbi Xu, Chuanxiao Xie
Environmental sustainability concerns make improving yield under lower N input a desirable breeding goal. To evaluate genetic variation and heterosis for low-N tolerance breeding, 28 F1 hybrids from a diallel scheme, along with their eight parental lines, were tested for agronomic traits including kernel number per ear (KNE) and grain yield per plant (GY), in replicated plots over two years under low-nitrogen (LN, without nitrogen application) and normal-nitrogen (NN, 220 kg N ha(-1)) conditions. Taken together the heritability in this and our previous studies, the correlation with grain yield, and the sensitivity to the stress for target trait selection, KNE was a good secondary target trait for LN selection in maize breeding...
December 2014: Breeding Science
Bruna Borelli, Roberto Sorrentino, Cecilia Goracci, Fernando Zarone, Marco Ferrari
To evaluate residual dentin thickness (RDT) after different tooth preparations, 90 sound maxillary anterior teeth were selected and divided into 3 groups according to tooth type (n = 30), namely, maxillary central incisors, maxillary lateral incisors, and maxillary canines. In each group, specimens were randomly divided and prepared for single-crown coverage with shoulder (SHO, n = 10, control), slight chamfer (CHA, n = 10), and knife-edge (KNE, n = 10) finish lines. After tooth preparation, specimens were sectioned and divided into 4 subgroups (buccal, distal, palatal, and mesial) according to measurement area...
March 2013: Journal of Oral Science
X H Liu, S L He, Z P Zheng, Z B Tan, Z Li, C He
Kernel number per ear (KNE) is one of the most important yield-related agronomic traits in maize (Zea mays). To clarify its genetic basis, we made a quantitative trait locus (QTL) analysis of KNE in a recombinant inbred line population derived from lines Mo17 and Huangzao4, under two nitrogen (N) regimes. Seven QTLs, on chromosomes 4, 6 and 9, were mapped under the high N regime, which explained phenotypic variation ranging from 5.03 to 15.49%. Under the low N regime, three QTLs were located on chromosomes 6 and 9, which accounted for phenotypic variation ranging from 8...
2011: Genetics and Molecular Research: GMR
Kevin Francis, Giovanni Gadda
Among the enzymes that catalyze the oxidative denitrification of nitroalkanes to carbonyl compounds, 2-nitropropane dioxygenase is the only one known to effectively utilize both the neutral and anionic (nitronate) forms of the substrate. A recent study has established that the catalytic pathway is common to both types of substrates, except for the initial removal of a proton from the carbon of the neutral substrates [Francis, K., Russell, B., and Gadda, G. (2005) J. Biol. Chem. 280, 5195-5204]. In the present study, the mechanistic properties of the enzyme have been investigated with solvent viscosity, pH, and kinetic isotope effects...
November 21, 2006: Biochemistry
George Peat, Laurence Wood, Ross Wilkie, Elaine Thomas
BACKGROUND AND OBJECTIVES: Clinical history and examination remain the cornerstones of diagnosis, prognosis, estimates of severity, and treatment selection in primary care for older adults presenting with knee pain. In this study we investigated the extent and cause of inter- and intraobserver variability of the clinical history using a structured, quantitative, clinical interview (KNE-SCI). METHODS: 58 patients aged 50 years and over with current knee pain were independently interviewed by two trained observers and again by one of these observers a month later...
November 2003: Journal of Clinical Epidemiology
G Peat, H Lawton, E Hay, J Greig, E Thomas
OBJECTIVE: To develop a standardized clinical interview, incorporating the perspectives of general practitioners (GPs) and rheumatologists, for primary care clinical epidemiological studies of adults aged 50 yr and over with knee problems. METHODS: Two parallel, consensus development studies using a modified nominal group technique involving GPs (n=5) and consultant rheumatologists (n=4) from North Staffordshire with reference panels of GPs (n=28) and rheumatologists (n=11) from selected centres in Great Britain, respectively...
October 2002: Rheumatology
Y Suzuki, Y Haruna, H Kobayashi, K Kawakubo, S Goto, A Gunji
Due to prolonged bed rest (BR), maximal oxygen uptake (VO2max) might be decreased by above -8%, even if a moderate supine bicycle exercise (SBE) was performed for 45 to 60 minutes every day during BR. However, the decrement of VO2max was lowered to below -5% by isometric training and using a reverse gradient garment. Further it was rather slightly increased by SBE training with gradually increasing load from 40% to 90% VO2max. The facts suggest the dependency of the decrease of VO2max during BR on exercising muscle mass (MM) and strength...
July 1997: Journal of Gravitational Physiology: a Journal of the International Society for Gravitational Physiology
T Kne, R Young, L Spillane
The objective of this study was to examine the pattern of emergency department (ED) use by frequent ED users over time. This study was a retrospective study of adults with more than 10 visits to a university hospital ED from 8/90 through 7/91. ED visits of this cohort to all hospitals in the metropolitan area were followed for 3 years. Records were reviewed for the etiology of each patient's ED visits. This cohort was comprised of 76 patients making 1,119 (1.9%) of the total 59,051 ED visits. Thirty-five of the 76 (46%) were frequent ED users in only the initial year...
November 1998: American Journal of Emergency Medicine
Olson, Chavez, Conklin, Cousins, Farrell, Ferlic, Keen, Kne, Kowalski, Veldman
The renin/angiotensin system (RAS) is a tonic anti-drop regulator of arterial blood pressure in many teleosts. In trout, angiotensin II (ANG II) has no direct constrictor effect on large arteries or veins and the identity of specific cardiovascular pressor effectors is unknown. Potential targets of angiotensin activation were examined in the present experiments using perfused organs and isolated tissues from the rainbow trout Oncorhynchus mykiss. Perfused gill (arches 2 and 3), perfused skeletal muscle-kidney (via the dorsal aorta; PDA) and perfused splanchnic (via the celiacomesenteric; PCM) circulations vasoconstrict in response to salmonid ANG II in a dose-dependent manner...
September 1994: Journal of Experimental Biology
T Kne, M W Shaw, E F Garfield, J Hicks
The Ravenswood-Stanford Coalition for At-Risk Children promotes school success by intervening with K-3 students identified as drug-exposed, either prenatally or environmentally, enabling them to remain in regular classrooms rather than diverted to special education. This goal was accomplished through professional partnerships, home involvement, individual intervention plans, special school-based services, and mentorships. Results from the project indicate these children are not significantly different from their peers; home involvement promotes better school linkages and reinforces positive behavior change; appropriate short-term, school-based services can increase academic and behavioral performance; dedicated volunteers working individually with students accelerate change processes; and these special at-risk students must be assigned to caring, supportive, and predictable classrooms...
August 1994: Journal of School Health
C C Cockerham, B S Weir
The variances of actual inbreeding and coancestry in terms of their corresponding identities by descent were studied for finite populations. For inbreeding at a single locus, the total variance sigma 2 equal F(1-F) (F is the inbreeding coefficient) is comprised of a component sigma 2w within populations and a component sigma 2b between replicate populations. These variances increase in time to a maximum at about 1.1Ne generations for sigma 2w, about 2.3Ne generations for sigma 2b, and about 1.4 NE generations for sigma 2, and decrease thereafter (Ne is effective population size)...
February 1983: Theoretical Population Biology
Y Kne, O Kane
No abstract text is available yet for this article.
1967: Bulletin de la Société Médicale D'Afrique Noire de Langue Française
P G Schmid, C A Whiteis, R P Oda, D D Lund
Cold stress (4 degrees C) induces a pressor response and variable increases in an index of sympathetic neural function, the rate constant of norepinephrine turnover, kNE. In heart, presynaptic cholinergic muscarinic and alpha-2 adrenergic influences may contribute to regional variation in responses of kNE to cold stress. Animals were pretreated with vehicle, a muscarinic cholinergic antagonist, quinuclidinyl benzilate (QNB), an alpha-2 adrenergic antagonist, yohimbine (YOH) or combined QNB + YOH. An increase in kNE was determined from incorporation of radiolabeled tyrosine into norepinephrine in a control period at 24 degrees C and again at 4 degrees C...
August 1986: Journal of Pharmacology and Experimental Therapeutics
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