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https://www.readbyqxmd.com/read/29222662/enhanced-activity-and-stability-of-la-doped-ceo2-monolithic-catalysts-for-lean-oxygen-methane-combustion
#1
Wenjun Zhu, Jianhui Jin, Xiao Chen, Chuang Li, Tonghua Wang, Chi-Wing Tsang, Changhai Liang
Effective utilization of coal bed methane is very significant for energy utilization and environment protection. Catalytic combustion of methane is a promising way to eliminate trace amounts of oxygen in the coal bed methane and the key to this technology is the development of high-efficiency catalysts. Herein, we report a series of Ce1-xLaxO2-δ (x = 0-0.8) monolithic catalysts for the catalytic combustion of methane, which are prepared by citric acid method. The structural characterization shows that the substitution of La enhance the oxygen vacancy concentration and reducibility of the supports and promote the migration of the surface oxygen, as a result improve the catalytic activity of CeO2...
December 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29221901/role-of-heel-lifting-in-standing-balance-recovery-a-simulation-study
#2
Kuangyou B Cheng, Hiroko Tanabe, Wen-Chien Chen, Hung-Ta Chiu
Although lifting the heels has frequently been observed during balance recovery, the function of this movement has generally been overlooked. The present study aimed to investigate the functional role of heel lifting during regaining balance from a perturbed state. Computer simulation was employed to objectively examine the effect of allowing/constraining heel lifting on balance performance. The human model consisted of 3 rigid body segments connected by frictionless joints. Movements were driven by joint torques depending on current joint angle, angular velocity, and activation level...
December 2, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29221645/primary-care-led-weight-management-for-remission-of-type-2-diabetes-direct-an-open-label-cluster-randomised-trial
#3
Michael Ej Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Carl Peters, Sviatlana Zhyzhneuskaya, Ahmad Al-Mrabeh, Kieren G Hollingsworth, Angela M Rodrigues, Lucia Rehackova, Ashley J Adamson, Falko F Sniehotta, John C Mathers, Hazel M Ross, Yvonne McIlvenna, Renae Stefanetti, Michael Trenell, Paul Welsh, Sharon Kean, Ian Ford, Alex McConnachie, Naveed Sattar, Roy Taylor
BACKGROUND: Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management within routine primary care would achieve remission of type 2 diabetes. METHODS: We did this open-label, cluster-randomised trial (DiRECT) at 49 primary care practices in Scotland and the Tyneside region of England. Practices were randomly assigned (1:1), via a computer-generated list, to provide either a weight management programme (intervention) or best-practice care by guidelines (control), with stratification for study site (Tyneside or Scotland) and practice list size (>5700 or ≤5700)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29221501/lean-methodology-reduces-inappropriate-use-of-antipsychotics-for-agitation-at-a-psychiatric-hospital
#4
Joshana K Goga, Antonio Depaolo, Sunil Khushalani, J Ken Walters, Robert Roca, Marc Zisselman, Christopher Borleis
OBJECTIVE: To Evaluate the Effects of Applying Lean Methodology-Improving Quality Increasing Efficiency by Eliminating Waste and Reducing Costs-An Approach To Decrease the Prescribing Frequency of Antipsychotics for The Indication of Agitation. DESIGN: Historically Controlled Study. SETTING: Bheppard Pratt Health System is the Largest Private Provider of Psychiatric Care in Maryland With a Total Bed Capacity of 300. There Were 4 337 Patient Days From November 1 2012 to October 31 2013 on the Dementia Unit...
January 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29220752/genomic-characterization-of-the-porcine-crtc3-and-the-effects-of-a-non-synonymous-mutation-p-v515f-on-lean-meat-production-and-belly-fat
#5
S H Lee, M H Hur, E A Lee, K C Hong, J M Kim
cAMP-responsive element-binding protein (CREB)-regulated transcriptional coactivator 3 (CRTC3) is well known to be related to obesity in humans and mice. However, the effects of CRTC3 have not been studied in pigs. Here, we characterized the structure of the porcine CRTC3 gene and identified single nucleotide polymorphisms (SNPs) in its coding region. Moreover, mRNA expression profiles of CRTC3 in muscle and fat tissues were examined. Of the 40 identified SNPs, the p.V515F mutation, located on exon 16, was genotyped in 368 Yorkshire pigs...
November 20, 2017: Meat Science
https://www.readbyqxmd.com/read/29220408/comparison-of-goto-kakizaki-rats-and-high-fat-diet-induced-obese-rats-are-they-reliable-models-to-study-type-2-diabetes-mellitus
#6
Wilson Mitsuo Tatagiba Kuwabara, Ana Carolina Panveloski-Costa, Caroline Naomi Fukusawa Yokota, Joice Naiara Bertaglia Pereira, Jorge Mancini Filho, Rosangela Pavan Torres, Sandro Massao Hirabara, Rui Curi, Tatiana Carolina Alba-Loureiro
Type 2 Diabetes mellitus (T2DM) is an evident growing disease that affects different cultures throughout the world. T2DM occurs under the influence of three main factors: the genetic background, environmental and behavioral components. Obesity is strongly associated to the development of T2DM in the occident, while in the orient most of the diabetic patients are considered lean. Genetics may be a key factor in the development of T2DM in societies where obesity is not a recurrent public health problem. Herein, two different models of rats were used to understand their differences and reliability as experimental models to study the pathophysiology of T2DM, in two different approaches: the genetic (GK rats) and the environmental (HFD-induced obese rats) influences...
2017: PloS One
https://www.readbyqxmd.com/read/29219895/effect-of-8-week-of-hospital-based-resistance-training-program-on-tcd4-cell-count-and-anthropometric-characteristic-of-hiv-patients-in-tehran-iran-a-randomized-controlled-trial
#7
Morteza Ghayomzadeh, SeyedAhmad SeyedAlinaghi, Mahdieh Molanouri Shamsi, Sajjad Rezaei, Conrad P Earnest, Sima Akbarnejad, Leila Taj, Minoo Mohraz, James Wilfred Navalta, Peyman Ghasemi, Fabrício Azevedo Voltarelli
We examined the effects of an 8 w circuit resistance training (RES) program using elastic bands and body weight on TCD4+ cell counts and anthropometry in HIV patients. Patients (N=21) receiving antiretroviral therapy were randomly assigned to resistance training (RES; n=14) or control group (CON; n=7) groups. RES (3/w) consisted of training with elastic bands and bodyweight training focusing on major muscle groups. CON received standard care. Statistical analyses were performed using general linear models adjusted for age, gender, length of infection and respective baseline measures...
December 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29219006/distribution-and-quantitative-analysis-of-cidea-and-cidec-in-broiler-chickens-accounting-for-differential-fat-deposition-between-strains
#8
J Huang, L Huang, Q Zeng, E Huang, H Liang, Q Wei, X Xie, J Ruan
1. Differences in the expression of CIDEa and CIDEc in 20 different tissues were examined. Both CIDEa and CIDEc mRNA transcripts were predominantly but variably expressed in white adipose tissue (WAT) but were also expressed at moderate levels in the kidney and liver and at lower levels in the ovary. Interestingly, among white adipose tissue types, both CIDEa and CIDEc were expressed at the lowest levels in hWAT (heart coronary white adipose tissue). 2. To better understand the roles of CIDEa and CIDEc in the fat deposition of broiler chickens, the differences in lipid droplet size and mRNA levels of CIDEa and CIDEc between lean-type and fat-type broiler chicken lines was studied...
December 8, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29218921/machine-learning-and-deep-analytics-for-biocomputing-call-for-better-explainability
#9
Dragutin Petkovic, Lester Kobzik, Christopher Re
The goals of this workshop are to discuss challenges in explainability of current Machine Leaning and Deep Analytics (MLDA) used in biocomputing and to start the discussion on ways to improve it. We define explainability in MLDA as easy to use information explaining why and how the MLDA approach made its decisions. We believe that much greater effort is needed to address the issue of MLDA explainability because of: 1) the ever increasing use and dependence on MLDA in biocomputing including the need for increased adoption by non-MLD experts; 2) the diversity, complexity and scale of biocomputing data and MLDA algorithms; 3) the emerging importance of MLDA-based decisions in patient care, in daily research, as well as in the development of new costly medical procedures and drugs...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29217665/critical-determinants-of-combined-sprint-and-endurance-performance-an-integrative-analysis-from-muscle-fiber-to-the-human-body
#10
Stephan van der Zwaard, Willem J van der Laarse, Guido Weide, Frank W Bloemers, Mathijs J Hofmijster, Koen Levels, Dionne A Noordhof, Jos J de Koning, Cornelis J de Ruiter, Richard T Jaspers
Optimizing physical performance is a major goal in current physiology. However, basic understanding of combining high sprint and endurance performance is currently lacking. This study identifies critical determinants of combined sprint and endurance performance using multiple regression analyses of physiologic determinants at different biologic levels. Cyclists, including 6 international sprint, 8 team pursuit, and 14 road cyclists, completed a Wingate test and 15-km time trial to obtain sprint and endurance performance results, respectively...
December 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29216746/employing-a-fixed-lean-multiple-schedule-in-the-treatment-of-challenging-behavior-for-children-with-autism-spectrum-disorder
#11
Shaji S Haq, Wendy Machalicek, S Andrew Garbacz, Christine Drew
Despite its utility, there is limited applied research on employing fixed-lean (FL) schedules of reinforcement in treatment packages to address challenging behavior. One potential reason is that abrupt shifts to terminal schedules of reinforcement have been associated with immediate increases in challenging behavior before subsiding to clinically acceptable levels. The purpose of the present study was to (a) provide evidence demonstrating the utility of a FL multiple schedule (MS) in the treatment of challenging behavior in applied settings, (b) examine the potential effects of alternative stimuli on challenging behavior during a FL MS, and (c) assess the social validity of this treatment package with participants and caregivers...
December 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/29216392/dioxin-like-pcb-126-increases-systemic-inflammation-and-accelerates-atherosclerosis-in-lean-ldl-receptor-deficient-mice
#12
Michael C Petriello, J Anthony Brandon, Jessie Hoffman, Chunyan Wang, Himi Tripathi, Ahmed Abdel-Latif, Xiang Ye, Xiangan Li, Liping Yang, Eun Lee, Sony Soman, Jazmyne Barney, Banrida Wahlang, Bernhard Hennig, Andrew J Morris
Exposure to dioxins and related persistent organic pollutants likely contributes to cardiovascular disease (CVD) risk through multiple mechanisms including the induction of chronic inflammation. Epidemiological studies have shown that leaner individuals may be more susceptible to the detrimental effects of lipophilic toxicants because they lack large adipose tissue depots that can accumulate and sequester these pollutants. This phenomenon complicates efforts to study mechanisms of pollutant-accelerated atherosclerosis in experimental animal models where high-fat feeding and adipose expansion limit the bioavailability of lipophilic pollutants...
December 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29216357/parental-history-of-type-2-diabetes-abrogates-ethnic-disparities-in-key-glucoregulatory-indices
#13
Ebenezer Nyenwe, Ibiye Owei, Jim Wan, Sam Dagogo-Jack
Background: There are ethnic differences in glucoregulation and prevalence of type 2 diabetes but studies on the role of genetics in modifying ethnic effects in normoglycemic African-Americans and Caucasians are limited. Therefore, we investigated glucoregulation in normoglycemic African-Americans and Caucasians with or without parental diabetes. Design and Methods: Fifty subjects with parental diabetes (from the POP-ABC cohort) and 50 subjects without parental diabetes were matched in age, sex, ethnicity, and BMI...
December 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29215962/personal-exposure-to-fine-particulate-matter-concentrations-in-central-business-district-of-a-tropical-coastal-city
#14
Jyothi S Menon, S M Shiva Nagendra
In the present study, personal exposure to fine particulate matter (PM2.5) concentrations in an urban hotspot (CBD: central business district) was investigated. The PM monitoring campaigns were carried out at an urban hotspot from June to October 2015. The personal exposure monitoring was performed during three different time periods, i.e. morning (8AM -9AM), afternoon (12.30PM-1.30PM) and evening (4PM-5PM), to cover both the peak and lean hour activities of the CBD. The median PM2.5 concentrations were 38...
December 7, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29215172/fibroblast-growth-factor-21-increases-hepatic-oxidative-capacity-but-not-physical-activity-or-energy-expenditure-in-hepatic-pgc-1%C3%AE-deficient-mice
#15
Justin A Fletcher, Melissa A Linden, Ryan D Sheldon, Grace M Meers, E Matthew Morris, Anthony Butterfield, James W Perfield, R Scott Rector, John P Thyfault
Fibroblast growth factor 21 (FGF21) treatment drives metabolic improvements, including increased metabolic flux and reduced hepatic steatosis, but mechanisms responsible for these effects remain to be fully elucidated. We tested if a targeted reduction in hepatic PGC-1α, which has been shown to occur with obesity, negatively impacted the metabolic effects of FGF21. We infused FGF21 (1 mg kg-1  day-1 ) or saline in chow-fed wild-type (WT) and liver-specific PGC-1α +/- (LPGC-1α) mice for 4 weeks. FGF21 administration lowered serum insulin and cholesterol (P ≤ 0...
December 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29215066/pharmacological-inhibition-of-rev-erb-stimulates-differentiation-inhibits-turnover-and-reduces-fibrosis-in-dystrophic-muscle
#16
Ryan D Welch, Cyrielle Billon, Aurore-Cecile Valfort, Thomas P Burris, Colin A Flaveny
Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal. DMD patients lack the expression of the structural protein dystrophin caused by mutations within the DMD gene. The absence of functional dystrophin protein results in excessive damage from normal muscle use due to the compromised structural integrity of the dystrophin associated glycoprotein complex. As a result, DMD patients exhibit ongoing cycles of muscle destruction and regeneration that promote inflammation, fibrosis, mitochondrial dysfunction, satellite cell (SC) exhaustion and loss of skeletal and cardiac muscle function...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214923/creatine-supplementation-elicits-greater-muscle-hypertrophy-in-upper-than-lower-limbs-and-trunk-in-resistance-trained-men
#17
João Pedro Nunes, Alex S Ribeiro, Brad J Schoenfeld, Crisieli M Tomeleri, Ademar Avelar, Michele Cc Trindade, Hellen Cg Nabuco, Edilaine F Cavalcante, Paulo Sugihara Junior, Rodrigo R Fernandes, Ferdinando O Carvalho, Edilson S Cyrino
BACKGROUND: Creatine (Cr) supplementation associated with resistance training produces greater muscular strength improvements in the upper compared with the lower body; however, no study has investigated if such region-specific results are seen with gains in muscle mass. AIM: We aimed to evaluate the effect of Cr supplementation in combination with resistance training on lean soft tissue changes in the upper and lower limbs and trunk in resistance-trained young adult men...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29214191/vascular-mechanotransduction-data-in-a-rodent-model-of-diabetes-pressure-induced-regulation-of-shp2-and-associated-signaling-in-the-rat-inferior-vena-cava
#18
Kevin M Rice, Nandini D P K Manne, Ravikumar Arvapalli, Gautam K Ginjupalli, Eric R Blough
The effect of diabetes on vascular mechano-transductive response is of great concern. Given the higher rate of vein graft failures associated with diabetes, understanding the multiple cellular and molecular events associated with vascular remodeling is of vital importance. This article represents data related to a study published in Cardiovascular Diabetology [1] (Rice et al., 2006) and Open Journal of Endocrine and Metabolic Diseases [2] (Rice et al., 2015) evaluating the effect of pressurization on rat inferior venae cavae (IVC)...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29213261/antibiotic-induced-alterations-in-gut-microbiota-are-associated-with-changes-in-glucose-metabolism-in-healthy-mice
#19
Richard R Rodrigues, Renee L Greer, Xiaoxi Dong, Karen N DSouza, Manoj Gurung, Jia Y Wu, Andrey Morgun, Natalia Shulzhenko
The gut microbiome plays an important role in health and disease. Antibiotics are known to alter gut microbiota, yet their effects on glucose tolerance in lean, normoglycemic mice have not been widely investigated. In this study, we aimed to explore mechanisms by which treatment of lean mice with antibiotics (ampicillin, metronidazole, neomycin, vancomycin, or their cocktail) influences the microbiome and glucose metabolism. Specifically, we sought to: (i) study the effects on body weight, fasting glucose, glucose tolerance, and fasting insulin, (ii) examine the changes in expression of key genes of the bile acid and glucose metabolic pathways in the liver and ileum, (iii) identify the shifts in the cecal microbiota, and (iv) infer interactions between gene expression, microbiome, and the metabolic parameters...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29213245/implication-of-free-fatty-acids-in-thrombin-generation-and-fibrinolysis-in-vascular-inflammation-in-zucker-rats-and-evolution-with-aging
#20
Jérémy Lagrange, Mélusine Didelot, Amel Mohamadi, Lucy A Walton, Saartje Bloemen, Bas de Laat, Huguette Louis, Simon N Thornton, Brian Derby, Michael J Sherratt, Bruno Fève, Pascal Challande, Riaz Akhtar, J Kennedy Cruickshank, Patrick Lacolley, Véronique Regnault
Background: The metabolic syndrome (MetS) and aging are associated with modifications in blood coagulation factors, vascular inflammation, and increased risk of thrombosis. Objectives: Our aim was to determine concomitant changes in thrombin generation in the blood compartment and at the surface of vascular smooth muscle cells (VSMCs) and its interplay with adipokines, free fatty acids (FFA), and metalloproteinases (MMPs) in obese Zucker rats that share features of the human MetS. Methods: Obese and age-matched lean Zucker rats were compared at 25 and 80 weeks of age...
2017: Frontiers in Physiology
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