keyword
MENU ▼
Read by QxMD icon Read
search

Lean

keyword
https://www.readbyqxmd.com/read/28646876/not-all-waits-are-equal-an-exploratory-investigation-of-emergency-care-patient-pathways
#1
Dawn Swancutt, Sian Joel-Edgar, Michael Allen, Daniel Thomas, Heather Brant, Jonathan Benger, Richard Byng, Jonathan Pinkney
BACKGROUND: Increasing pressure in the United Kingdom (UK) urgent care system has led to Emergency Departments (EDs) failing to meet the national requirement that 95% of patients are admitted, discharged or transferred within 4-h of arrival. Despite the target being the same for all acute hospitals, individual Trusts organise their services in different ways. The impact of this variation on patient journey time and waiting is unknown. Our study aimed to apply the Lean technique of Value Stream Mapping (VSM) to investigate care processes and delays in patient journeys at four contrasting hospitals...
June 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28646476/the-relationship-between-circulating-adiponectin-leptin-and-vaspin-with-bone-mineral-density-bmd-arterial-calcification-and-stiffness-a-cross-sectional-study-in-post-menopausal-women
#2
N Tanna, K Patel, A E Moore, D Dulnoan, S Edwards, G Hampson
OBJECTIVE: To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women. We hypothesised that adipokines produced by adipose tissue may be mediators of bone and cardiovascular disease (CVD) and explain, in part, the observed association between osteoporosis and CVD. DESIGN: We studied 386 ambulant community dwelling postmenopausal women aged (mean [SD] 61 [6...
June 23, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28646101/serum-androgen-profile-and-physical-performance-in-women-olympic-athletes
#3
Emma Eklund, Bo Berglund, Fernand Labrie, Kjell Carlström, Lena Ekström, Angelica Lindén Hirschberg
BACKGROUND: The role of endogenous androgens for body composition and physical performance in women athletes is still not elucidated. AIM: To examine the serum androgen profile in relation to body composition and physical performance in women Olympic athletes and to compare endocrine variables and body composition to controls. STUDY DESIGN: Cross-sectional study, conducted between 2011 and 2015 at the Women's Health Research Unit, Karolinska University Hospital, Stockholm...
June 23, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28645653/catalase-overexpression-modulates-metabolic-parameters-in-a-new-stress-less-leptin-deficient-mouse-model
#4
Deborah L Amos, Tanner Robinson, Melissa B Massie, Carla Cook, Alexis Hoffsted, Courtney Crain, Nalini Santanam
Oxidative stress plays a key role in obesity by modifying the function of important biological molecules, thus altering obesogenic pathways such as glucose and lipid signaling. Catalase, is an important endogenous antioxidant enzyme that catabolizes hydrogen peroxide produced by the dismutation of superoxide. Recent studies have shown knockdown of catalase exacerbates insulin resistance and leads to obesity. We hypothesized that overexpressing catalase in an obese mouse will modulate obesogenic pathways and protect against obesity...
June 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28645478/a-tspo-ligand-prevents-mitochondrial-sterol-accumulation-and-dysfunction-during-myocardial-ischemia-reperfusion-in-hypercholesterolemic-rats
#5
Julien Musman, Stéphanie Paradis, Mathieu Panel, Sandrine Pons, Caroline Barau, Claudio Caccia, Valerio Leoni, Bijan Ghaleh, Didier Morin
A major cause of cell death during myocardial ischemia-reperfusion is mitochondrial dysfunction. We previously showed that the reperfusion of an ischemic myocardium was associated with an accumulation of cholesterol into mitochondria and a concomitant strong generation of auto-oxidized oxysterols. The inhibition of mitochondrial accumulation of cholesterol abolished the formation of oxysterols and prevented mitochondrial injury at reperfusion. The aim of this study was to investigate the impact of hypercholesterolemia on sterol and oxysterol accumulation in rat cardiac cytosols and mitochondria and to analyse the effect of the translocator protein ligand 4'-chlorodiazepam on this accumulation and mitochondrial function...
June 20, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28645093/identification-of-key-outcome-measures-when-using-the-instrumented-timed-up-and-go-and-or-posturography-for-fall-screening
#6
Renee Beach Sample, Allison L Kinney, Kurt Jackson, Wiebke Diestelkamp, Kimberly Edginton Bigelow
The Timed Up and Go (TUG) has been commonly used for fall risk assessment. The instrumented Timed Up and Go (iTUG) adds wearable sensors to capture sub-movements and may be more sensitive. Posturography assessments have also been used for determining fall risk. This study used stepwise logistic regression models to identify key outcome measures for the iTUG and posturography protocols. The effectiveness of the models containing these measures in differentiating fallers from non-fallers were then compared for each: iTUG total time duration only, iTUG, posturography, and combined iTUG and posturography assessments...
June 10, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28644700/intermittent-ischemic-preconditioning-protects-against-hepatic-ischemia-reperfusion-injury-and-extensive-hepatectomy-in-steatotic-rat-liver
#7
Nikolaos Sikalias, Theodore Karatzas, Konstantinos Alexiou, Lamprini Mountzalia, Maria Demonakou, Ioannis D Kostakis, Argyro Zacharioudaki, Apostolos Papalois, Gregory Kouraklis
BACKGROUND: Hepatic steatosis causes severe liver damage and has deleterious effects when associated with ischemia-reperfusion mechanisms. Ischemic preconditioning (IPC) protects lean liver against prolonged ischemia by improving micro-circulation and reducing lipid peroxidation. We investigated the effect of intermittent IPC on liver ischemia-reperfusion injury (IRI) and extensive hepatectomy in severe hepatic steatosis. METHODS: Severe hepatic steatosis was performed by 12-14 weeks of choline-free diet in 108 Wistar rats...
June 23, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28643356/bimagrumab-improves-body-composition-and-insulin-sensitivity-in-insulin-resistant-subjects
#8
Tania Garito, Ronenn Roubenoff, Marcus Hompesch, Linda Morrow, Katherine Gomez, Daniel Rooks, Charles Meyers, Monte Buchsbaum, Srikanth Neelakantham, Therese Swan, Lee Anne Filosa, Didier Laurent, Olivier Petricoul, Marjorie Zakaria
BACKGROUND: Skeletal muscle is a key mediator of insulin resistance. Bimagrumab, an antibody against activin receptor type II (ActRII), prevents binding of negative muscle regulators, like myostatin, and increases lean mass and decreases fat mass in animal models. OBJECTIVE: We hypothesized that an improving body composition in insulin resistant individuals could enhance insulin sensitivity. METHODS: Sixteen individuals with mean body mass index (BMI) = 29...
June 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28642676/international-society-of-sports-nutrition-position-stand-protein-and-exercise
#9
REVIEW
Ralf Jäger, Chad M Kerksick, Bill I Campbell, Paul J Cribb, Shawn D Wells, Tim M Skwiat, Martin Purpura, Tim N Ziegenfuss, Arny A Ferrando, Shawn M Arent, Abbie E Smith-Ryan, Jeffrey R Stout, Paul J Arciero, Michael J Ormsbee, Lem W Taylor, Colin D Wilborn, Doug S Kalman, Richard B Kreider, Darryn S Willoughby, Jay R Hoffman, Jamie L Krzykowski, Jose Antonio
The International Society of Sports Nutrition (ISSN) provides an objective and critical review related to the intake of protein for healthy, exercising individuals. Based on the current available literature, the position of the Society is as follows:An acute exercise stimulus, particularly resistance exercise, and protein ingestion both stimulate muscle protein synthesis (MPS) and are synergistic when protein consumption occurs before or after resistance exercise.For building muscle mass and for maintaining muscle mass through a positive muscle protein balance, an overall daily protein intake in the range of 1...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28642493/diffusional-displacive-transformation-enables-formation-of-long-period-stacking-order-in-magnesium
#10
Jin-Kyung Kim, Lei Jin, Stefanie Sandlöbes, Dierk Raabe
Mg is the most important lightweight engineering alloy enabling future weight-reduced and fuel-saving engineering solutions. Yet, Mg is soft. Long-period stacking ordered (LPSO) structures in Mg alloys have unique crystal structures, characterized by both complex chemical and stacking order. They are essential for strengthening of Mg alloys. The formation mechanism of these LPSO structures is still under discussion. Here we report that Y/Zn enriched Guinier-Preston (GP) zones observed in a lean Mg-Y-Zn model alloy are precursors of early stage LPSO structures...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642059/new-trends-on-obesity-and-nafld-in-asia
#11
REVIEW
Jian-Gao Fan, Seung-Up Kim, Vincent Wai-Sun Wong
Traditionally, obesity and its related diseases are considered problems in Western countries. However, in the past two decades, urbanization in many Asian countries has led to sedentary lifestyle and overnutrition, and has set the stage for the epidemic of obesity. This article reviews the epidemiological trend of obesity in Asia with special emphasis on the emerging condition of non-alcoholic fatty liver disease (NAFLD). Currently, the population prevalence of NAFLD in Asia is around 25%, similar to that in many Western countries...
June 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28641779/macrophage-functions-in-lean-and-obese-adipose-tissue
#12
REVIEW
Dylan Thomas, Caroline Apovian
Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forward loop of increasing inflammatory macrophage activation and worsening adipocyte dysfunction...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28641285/role-of-glycyrrhizin-in-the-reduction-of-inflammation-in-diabetic-kidney-disease
#13
Vikram Thakur, Syeda Nargis, Mayra Gonzalez, Swetak Pradhan, Daniel Terreros, Munmun Chattopadhyay
BACKGROUND: Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes. Recent evidence suggests chronic inflammation to be one of the causal factors of DKD. The mechanisms entailed are not completely elucidated except that a variety of cytokines play a major role in this process. High mobility group box 1 (HMGB1) is a pro-inflammatory toll-like receptor-4 (TLR4)-binding cytokine that is involved in inflammation-associated gene expression. This investigation was designed to assess the involvement of HMGB1, TLR-4, and nuclear factor (NF)-κB in the development of DKD and to evaluate that whether blocking HMGB1 by its natural inhibitor Glycyrrhizin (GLC) can reduce the progression of the disease...
June 23, 2017: Nephron
https://www.readbyqxmd.com/read/28641233/large-eddy-simulation-and-experimental-study-on-vented-gasoline-air-mixture-explosions-in-a-semi-confined-obstructed-pipe
#14
Guoqing Li, Yang Du, Shimao Wang, Sheng Qi, Peili Zhang, Wenzhuo Chen
In this work, LES simulation coupled with a TFC sub-grid combustion model has been performed in a semi-confined pipe (L/D=10, V=10L) in the presence of four hollow-square obstacles (BR=49.8%) with circular hollow cross-section, in order to study the premixed gasoline-air mixture explosions. The comparisons between simulated results and experimental results have been conducted. It was found that the simulated results were in good agreement with experimental data in terms of flame structures, flame locations and overpressure time histories...
June 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28640214/a-pilot-randomized-cross-over-trial-to-examine-the-effect-of-kiwifruit-on-satiety-and-measures-of-gastric-comfort-in-healthy-adult-males
#15
Alison Wallace, Sarah Eady, Lynley Drummond, Duncan Hedderley, Juliet Ansell, Richard Gearry
'Hayward' kiwifruit anecdotally are associated with improved gastrointestinal comfort following the consumption of high protein meals, possibly because of the presence of a protease enzyme, actinidin. The study aimed to use SmartPill™ technology to investigate the acute effect of kiwifruit with actinidin (Actinidia chinensis var. deliciosa 'Hayward') and kiwifruit without actinidin (A. chinensis var. chinensis 'Hort16A') on digestion of a large protein meal. Ten healthy male subjects were recruited. The participants attended the clinic three times, having fasted overnight...
June 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28639302/prospective-validation-of-pathologic-complete-response-models-in-rectal-cancer-transferability-and-reproducibility
#16
Johan van Soest, Elisa Meldolesi, Ruud van Stiphout, Roberto Gatta, Andrea Damiani, Vincenzo Valentini, Philippe Lambin, Andre Dekker
PURPOSE: Multiple models have been developed to predict pathologic complete response (pCR) in locally advanced rectal cancer patients. Unfortunately, validation of these models normally omit the implications of cohort differences on prediction model performance. In this work, we will perform a prospective validation of three pCR models, including information whether this validation will target transferability or reproducibility (cohort differences) of the given models. METHODS: We applied a novel methodology, the cohort differences model, to predict whether a patient belongs to the training or to the validation cohort...
June 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28639138/veterinary-vaccine-nanotechnology-pulmonary-and-nasal-delivery-in-livestock-animals
#17
REVIEW
Daniella Calderon-Nieva, Kalhari Bandara Goonewardene, Susantha Gomis, Marianna Foldvari
Veterinary vaccine development has several similarities with human vaccine development to improve the overall health and well-being of species. However, veterinary goals lean more toward feasible large-scale administration methods and low cost to high benefit immunization. Since the respiratory mucosa is easily accessible and most infectious agents begin their infection cycle at the mucosa, immunization through the respiratory route has been a highly attractive vaccine delivery strategy against infectious diseases...
June 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28638683/low-prevalence-of-obesity-in-beh%C3%A3-et-s-disease-is-associated-with-high-obestatin-level
#18
Süleyman Serdar Koca, Murat Kara, Metin Özgen, Ramazan Dayanan, Caner Feyzi Demir, Kader Aksoy, Nevin İlhan, Emir Dönder, Ahmet Işık
OBJECTIVE: Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to evaluate the prevalence of obesity and ghrelin and obestatin levels in patients with Behçet's disease (BD). MATERIAL AND METHODS: One hundred and forty-three (143) patients with BD and 112 healthy controls (HC) were enrolled. Participants were subdivided according to the body mass index (BMI) as lean (<18...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638220/green-tea-polyphenols-ameliorate-non-alcoholic-fatty-liver-disease-through-upregulating-ampk-activation-in-high-fat-fed-zucker-fatty-rats
#19
Yi Tan, Jane Kim, Jing Cheng, Madeleine Ong, Wei-Guo Lao, Xing-Liang Jin, Yi-Guang Lin, Linda Xiao, Xue-Qiong Zhu, Xian-Qin Qu
AIM: To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on non-alcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS: Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), inflammatory cytokines and hepatic triglyceride and liver histology...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28637773/follow-up-of-a-randomized-trial-on-postdischarge-nutrition-in-preterm-born-children-at-age-8-y
#20
Charlotte A Ruys, Monique van de Lagemaat, Martijn Jj Finken, Harrie N Lafeber
Background: Early nutritional interventions may modulate health risks in preterm-born infants. Previously, we showed that preterm-born infants fed an isocaloric protein- and mineral-enriched postdischarge formula (PDF) from term age to 6-mo corrected age (CA) gained more lean mass than did those fed term formula (TF). Long-term follow-up of randomized nutritional trials is important to test the hypothesis that short-term positive effects on health are sustainable.Objective: The aim of this follow-up study was to compare body size, body composition, and metabolic health at age 8 y in preterm-born children who were randomly assigned to receive either PDF or TF from term age until 6-mo CA...
June 21, 2017: American Journal of Clinical Nutrition
keyword
keyword
9442
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"