keyword
Keywords Ventricular structure-function...

Ventricular structure-function relation

https://read.qxmd.com/read/38315669/a-deep-patient-similarity-learning-framework-for-the-assessment-of-diastolic-dysfunction-in-elderly-patients
#21
JOURNAL ARTICLE
Rohan Shah, Marton Tokodi, Ankush Jamthikar, Sabha Bhatti, Ehimare Akhabue, Grace Casaclang-Verzosa, Naveena Yanamala, Partho P Sengupta
BACKGROUND AND AIMS: Age-related changes in cardiac structure and function are well recognized and make the clinical determination of abnormal LV diastolic function (LVDD) particularly challenging in the elderly. We investigated whether a deep neural network (DeepNN) model[70] of LVDD, previously validated in a younger cohort, can be implemented in an older population to predict incident heart failure (HF). METHODS: A previously developed DeepNN was tested on 5,596 older participants (66-90 years; 57% female; 20% black) from the Atherosclerosis Risk in Communities study...
February 5, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38314606/preeclampsia-associated-differences-in-the-placenta-fetal-brain-and-maternal-heart-can-be-demonstrated-antenatally-an-observational-cohort-study-using-mri
#22
JOURNAL ARTICLE
Megan Hall, Antonio de Marvao, Ronny Schweitzer, Daniel Cromb, Kathleen Colford, Priya Jandu, Declan P O'Regan, Alison Ho, Anthony Price, Lucy C Chappell, Mary A Rutherford, Lisa Story, Pablo Lamata, Jana Hutter
BACKGROUND: Preeclampsia is a multiorgan disease of pregnancy that has short- and long-term implications for the woman and fetus, whose immediate impact is poorly understood. We present a novel multiorgan approach to magnetic resonance imaging (MRI) investigation of preeclampsia, with the acquisition of maternal cardiac, placental, and fetal brain anatomic and functional imaging. METHODS: An observational study was performed recruiting 3 groups of pregnant women: those with preeclampsia, chronic hypertension, or no medical complications...
February 5, 2024: Hypertension
https://read.qxmd.com/read/38309367/structure-activity-relationships-for-alkyl-phenanthrenes-support-two-independent-but-interacting-synergistic-models-for-pac-mixture-potency
#23
JOURNAL ARTICLE
John P Incardona, Tiffany L Linbo, James R Cameron, Nathaniel L Scholz
Multiple lines of evidence at whole animal, cellular and molecular levels implicate polycyclic aromatic compounds (PACs) with three rings as drivers of crude oil toxicity to developing fish. Phenanthrene (P0) and its alkylated homologs (C1- through C4-phenanthrenes) comprise the most prominent subfraction of tricyclic PACs in crude oils. Among this family, P0 has been studied intensively, with more limited detail available for the C4-phenanthrene 1-methyl-7-isopropyl-phenanthrene (1-M,7-IP, or retene). While both compounds are cardiotoxic, P0 impacts embryonic cardiac function and development through direct blockade of K+ and Ca2+ currents that regulate cardiomyocyte contractions...
February 1, 2024: Science of the Total Environment
https://read.qxmd.com/read/38306359/left-ventricle-function-and-post-transcriptional-events-with-exercise-training-in-pigs
#24
JOURNAL ARTICLE
Stephanie L Samani, Shayne C Barlow, Lisa A Freeburg, Traci L Jones, Marlee Poole, Mark A Sarzynski, Michael R Zile, Tarek Shazly, Francis G Spinale
BACKGROUND: Standardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly diastolic function and relation to post-transcriptional molecular pathways (microRNAs (miRs)) are poorly understood. This project tested the central hypothesis that adaptive LV remodeling resulting from a large animal exercise training protocol, would be directly associated with specific miRs responsible for regulating pathways relevant to LV myocardial stiffness and geometry...
2024: PloS One
https://read.qxmd.com/read/38301728/right-ventricular-structure-and-function-in-adolescent-athletes-a-3d-echocardiographic-study
#25
JOURNAL ARTICLE
Adrienn Ujvári, Alexandra Fábián, Balint Lakatos, Márton Tokodi, Zsuzsanna Ladányi, Nóra Sydó, Emese Csulak, Hajnalka Vágó, Vencel Juhász, Kinga Grebur, Andrea Szűcs, Márk Zámodics, Máté Babity, Orsolya Kiss, Béla Merkely, Attila Kovács
The aim of this study was to characterize the right ventricular (RV) contraction pattern and its associations with exercise capacity in a large cohort of adolescent athletes using resting three-dimensional echocardiography (3DE). We enrolled 215 adolescent athletes (16±1 years, 169 males, 12±6 hours of training/week) and compared them to 38 age- and sex-matched healthy, sedentary adolescents. We measured the 3DE-derived biventricular ejection fractions (EF). We also determined the relative contributions of longitudinal EF (LEF/RVEF) and radial EF (REF/RVEF) to the RVEF...
February 1, 2024: International Journal of Sports Medicine
https://read.qxmd.com/read/38293941/leukocyte-telomere-length-and-cardiac-structure-and-function-a-mendelian-randomization-study
#26
JOURNAL ARTICLE
Ahmed M Salih, Ilaria Boscolo Galazzo, Gloria Menegaz, André Altmann
BACKGROUND: Existing research demonstrates the association of shorter leukocyte telomere length with increased risk of age-related health outcomes including cardiovascular diseases. However, the direct causality of these relationships has not been definitively established. Cardiovascular aging at an organ level may be captured using image-derived phenotypes of cardiac anatomy and function. METHODS AND RESULTS: In the current study, we use 2-sample Mendelian randomization to assess the causal link between leukocyte telomere length and 54 cardiac magnetic resonance imaging measures representing structure and function across the 4 cardiac chambers...
January 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38293793/features-of-cardiovascular-magnetic-resonance-native-t1-mapping-in-maintenance-hemodialysis-patients-and-their-related-factors
#27
JOURNAL ARTICLE
Changqin Zhang, Lijing Yao, Min Liu, Yilun Zhou
PURPOSE: Increased myocardial T1 values on cardiovascular MRI (CMRI) have been shown to be a surrogate marker for myocardial fibrosis. The use of CMRI in patients on hemodialysis (HD) remains limited. This research aimed to explore the characteristics of native T1 values in HD patients and identify factors related to T1 values. METHODS: A total of thirty-two patients on HD and fourteen healthy controls were included in this study. All participants underwent CMRI...
December 2024: Renal Failure
https://read.qxmd.com/read/38293745/cardiac-remodelling-in-non-alcoholic-fatty-liver-disease-in-the-general-population
#28
JOURNAL ARTICLE
Frederik Kostka, Till Ittermann, Stefan Groß, Fabian Christopher Laqua, Robin Bülow, Henry Völzke, Marcus Dörr, Jens Peter Kühn, Marcello Ricardo Paulista Markus, Marie-Luise Kromrey
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is associated with increased risk for cardiovascular disease. Our study investigates the contribution of NAFLD to changes in cardiac structure and function in a general population. METHODS: One thousand ninety-six adults (49.3% female) from the Study of Health in Pomerania underwent magnetic resonance imaging including cardiac and liver imaging. The presence of NAFLD by proton density fat fraction was related to left cardiac structure and function...
January 31, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/38291668/myocardial-proteome-changes-in-aortic-stenosis-rats-subjected-to-long-term-aerobic-exercise
#29
JOURNAL ARTICLE
Gustavo Augusto Ferreira Mota, Sérgio Luiz Borges de Souza, Danielle Fernandes Vileigas, Vitor Loureiro da Silva, Paula Grippa Sant'Ana, Licia Carla da Silva Costa, Carlos Roberto Padovani, Silméia Garcia Zanatti Bazan, Marília Afonso Rabelo Buzalaf, Lucilene Delazari Dos Santos, Marina Politi Okoshi, Mariana Gatto, Antonio Carlos Cicogna
The effects of exercise training (ET) on the heart of aortic stenosis (AS) rats are controversial and the mechanisms involved in alterations induced by ET have been poorly clarified. In this study, we analyzed the myocardial proteome to identify proteins modulated by moderate-intensity aerobic ET in rats with chronic supravalvular AS. Wistar rats were divided into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary aortic stenosis (AS-Sed), and exercised AS (AS-Ex). ET consisted of five treadmill running sessions per week for 16 weeks...
January 30, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38290462/early-application-of-sacubitril-valsartan-sodium-after-acute-myocardial-infarction-and-its-influence-on-ventricular-remodeling-and-tgf-%C3%AE-1-smad3-signaling-pathway
#30
JOURNAL ARTICLE
Linqing Wang, Yajing Zhang, Jieqian Xue, Yingxiao Da, Yanzhou Gao, Yunjing Sun, Song Zhou
OBJECTIVE: The objective of this study was to investigate the early application of sacubitril valsartan sodium (LCZ696) following acute myocardial infarction (AMI) and its impact on ventricular remodeling and the TGF-β1/Smad3 signaling pathway in patients. METHODS: The clinical data of 73 patients with AMI admitted to the hospital from June 2021 to September 2022 were retrospectively analyzed, and the patients were grouped according to the treatment methods, including 36 cases in the control group (conventional drug treatment) and 37 cases in the observation group (conventional drug + LCZ696 treatment)...
January 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38270932/why-is-early-onset-atrial-fibrillation-uncommon-in-patients-with-duchenne-muscular-dystrophy-insights-from-the-mdx-mouse
#31
JOURNAL ARTICLE
My-Nhan Nguyen, Charlotte Hooper, Matilde Stefanini, Besarte Vrellaku, Ricardo Carnicer, Matthew J Wood, Jillian N Simon, Barbara Casadei
BACKGROUND: A reduction in both dystrophin and neuronal nitric oxide synthase (NOS1) secondary to microRNA-31 (miR-31) upregulation contributes to the atrial electrical remodelling that underpins human and experimental atrial fibrillation (AF). By contrast, patients with Duchenne Muscular Dystrophy (DMD), who lack dystrophin and NOS1 and, at least in the skeletal muscle, have raised miR-31 expression, do not have increase susceptibility to AF in the absence of left ventricular (LV) dysfunction...
January 25, 2024: Cardiovascular Research
https://read.qxmd.com/read/38262578/chronic-kidney-disease-and-left-ventricular-diastolic-dysfunction-ckd-lvdd-alter-cardiac-expression-of-mitochondria-related-genes-in-swine
#32
JOURNAL ARTICLE
Alejandro R Chade, Rhys Sitz, Taylor J Kelty, Elizabeth McCarthy, Darla L Tharp, R Scott Rector, Alfonso Eirin
Cardiovascular disease and heart failure doubles in patients with chronic kidney disease (CKD), but the underlying mechanisms remain obscure. Mitochondria are central to maintaining cellular respiration and modulating cardiomyocyte function. We took advantage of our novel swine model of CKD and left ventricular diastolic dysfunction (CKD-LVDD) to investigate the expression of mitochondria-related genes and potential mechanisms regulating their expression. CKD-LVDD and normal control pigs (n=6/group, 3 males/3 females) were studied for 14 weeks...
January 21, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/38258596/artemisinin-attenuates-isoproterenol-induced-cardiac-hypertrophy-via-the-erk1-2-and-p38-mapk-signaling-pathways
#33
JOURNAL ARTICLE
Renxing Song, Chunming Xiong, Juncai Bai, Zhenzhou Bai, Wei Liu
BACKGROUND: Artemisinin (ART) is mainly derived from Artemisia annua, a traditional Chinese medicinal plant, and has been found to affect cellular biochemical processes, such as proliferation, angiogenesis, and apoptosis, in addition to its antimalarial properties. However, its effect on cardiac hypertrophy and the underlying mechanisms remain unclear. OBJECTIVES: This study aimed to investigate the effect of ART on cardiac hypertrophy and explore its possible mechanisms...
October 13, 2023: Current Molecular Pharmacology
https://read.qxmd.com/read/38256388/left-ventricular-mass-index-predicts-renal-function-decline-in-patients-with-chronic-kidney-disease
#34
JOURNAL ARTICLE
Antonio Lacquaniti, Fabrizio Ceresa, Susanna Campo, Francesco Patané, Paolo Monardo
Background and Objectives : Several studies revealed a relation between abnormal cardiac remodeling and glomerular filtration rate (GFR) decline, but there are limited data regarding echocardiographic changes in chronic kidney disease (CKD). This study evaluated the abnormal cardiac structures characterizing patients with CKD, assessing the independent association between echocardiographic parameters and the risk of decline in renal function. Materials and Methods: In total, 160 patients with CKD were studied...
January 10, 2024: Medicina
https://read.qxmd.com/read/38255202/a-closer-look-at-the-perivascular-unit-in-the-development-of-enlarged-perivascular-spaces-in-obesity-metabolic-syndrome-and-type-2-diabetes-mellitus
#35
REVIEW
Melvin R Hayden
The recently described perivascular unit (PVU) resides immediately adjacent to the true capillary neurovascular unit (NVU) in the postcapillary venule and contains the normal-benign perivascular spaces (PVS) and pathological enlarged perivascular spaces (EPVS). The PVS are important in that they have recently been identified to be the construct and the conduit responsible for the delivery of metabolic waste from the interstitial fluid to the ventricular cerebrospinal fluid for disposal into the systemic circulation, termed the glymphatic system...
January 2, 2024: Biomedicines
https://read.qxmd.com/read/38253779/phenotype-of-takayasu-like-vasculitis-and-cardiopathy-in-patients-with-blau-syndrome
#36
JOURNAL ARTICLE
Linqing Zhong, Wei Wang, Xiaoyan Tang, Yu Zhang, Lijuan Gou, Lin Wang, Changyan Wang, Shan Jian, Meiying Quan, Zhenjie Zhang, Zhongxun Yu, Zhengqing Qiu, Min Wei, Hongmei Song
OBJECTIVES: We aimed to determine the prevalence of cardiovascular involvement in our Blau syndrome (BS) cohort and provide detailed analysis of their cardiovascular manifestations and outcome. We also tried to find out the risk factors for developing cardiovascular involvement. METHODS: Clinical manifestations, laboratory findings, and treatments were reviewed. Clinical features were compared between children with cardiovascular involvement and those without angiocardiopathy...
January 22, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38242041/immune-cells-and-related-cytokines-in-dilated-cardiomyopathy
#37
REVIEW
Jingdi Zhang, Linlin Cheng, Zhan Li, Haolong Li, Yongmei Liu, Haoting Zhan, Honglin Xu, Yuan Huang, Futai Feng, Yongzhe Li
Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy involving one or more underlying etiologies. It is characterized by structural and functional dysfunction of the myocardium, potentially leading to fibrosis and ventricular remodeling, and an elevated risk of heart failure (HF). Although the pathogenesis of DCM remains unknown, compelling evidence suggests that DCM-triggered immune cells and inflammatory cascades play a crucial role in the occurrence and development of DCM. Various factors are linked to myocardial damage, inducing aberrant activation of the immune system and sustained inflammatory responses in DCM...
January 18, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38239133/effect-of-electroacupuncture-on-ventricular-structure-and-function-in-rats-with-myocardial-ischemia-reperfusion-injury
#38
JOURNAL ARTICLE
Shuang Wu, Wen Jiang, Ya-Ping Ding, Qiong-Qiong Liu, Hua Bai, Sen-Lei Xu, Hong-Ru Zhang, Ming-Hui Xia, Yi-Huang Gu
OBJECTIVES: To observe the effect of electroacupuncture (EA) on changes of ventricular structure and function in rats with myocardial ischemia-reperfusion injury (MIRI), so as to explore its potential mechanisms underlying improvement of ventricular remodeling after MIRI. METHODS: Forty male SD rats were randomly divided into 4 groups:sham operation group, model group, EA group and medication (sacubactril valsartan, LCZ696) group, with 10 rats in each group...
January 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/38212679/changes-in-the-shape-and-function-of-the-fetal-heart-of-pre-and-gestational-diabetes-mothers
#39
JOURNAL ARTICLE
Shuang Li, Linlin Wang, Huixia Yang, Lixin Fan
BACKGROUND: Hyperglycemia during pregnancy can affect fetal heart in many ways, including causing cardiac malformation, leading to hypertrophic cardiomyopathy and cardiac dysfunction. Echocardiographic evaluation can assist identify alterations in heart structure, morphology and function, enabling prompt monitoring and management. However, according to earlier research, the cardiac alterations are modest in hyperglycemic mothers' fetuses, and might not be detectable using conventional methods and it is also unclear whether these changes are related to the metabolism of mothers...
January 11, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38203602/-smc5-plays-independent-roles-in-congenital-heart-disease-and-neurodevelopmental-disability
#40
JOURNAL ARTICLE
Matthew P O'Brien, Marina V Pryzhkova, Evelyn M R Lake, Francesca Mandino, Xilin Shen, Ruchika Karnik, Alisa Atkins, Michelle J Xu, Weizhen Ji, Monica Konstantino, Martina Brueckner, Laura R Ment, Mustafa K Khokha, Philip W Jordan
Up to 50% of patients with severe congenital heart disease (CHD) develop life-altering neurodevelopmental disability (NDD). It has been presumed that NDD arises in CHD cases because of hypoxia before, during, or after cardiac surgery. Recent studies detected an enrichment in de novo mutations in CHD and NDD, as well as significant overlap between CHD and NDD candidate genes. However, there is limited evidence demonstrating that genes causing CHD can produce NDD independent of hypoxia. A patient with hypoplastic left heart syndrome and gross motor delay presented with a de novo mutation in SMC5 ...
December 28, 2023: International Journal of Molecular Sciences
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