keyword
https://read.qxmd.com/read/38402375/the-correlation-between-brain-structure-characteristics-and-emotion-regulation-ability-in-children-at-high-risk-of-autism-spectrum-disorder
#1
JOURNAL ARTICLE
Ning Ding, Linyan Fu, Lu Qian, Bei Sun, Chunyan Li, Huiyun Gao, Tianyu Lei, Xiaoyan Ke
As indicated by longitudinal observation, autism has difficulty controlling emotions to a certain extent in early childhood, and most children's emotional and behavioral problems are further aggravated with the growth of age. This study aimed at exploring the correlation between white matter and white matter fiber bundle connectivity characteristics and their emotional regulation ability in children with autism using machine learning methods, which can lay an empirical basis for early clinical intervention of autism...
February 24, 2024: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/38398422/paroxysmal-dystonic-posturing-mimicking-nocturnal-leg-cramps-as-a-presenting-sign-in-an-infant-with-dcc-mutation-callosal-agenesis-and-mirror-movements
#2
JOURNAL ARTICLE
Adriana Prato, Lara Cirnigliaro, Federica Maugeri, Antonina Luca, Loretta Giuliano, Giuseppina Vitiello, Edoardo Errichiello, Enza Maria Valente, Ennio Del Giudice, Giovanni Mostile, Renata Rizzo, Rita Barone
Background/Objectives : Pathogenic variants in the deleted in colorectal cancer gene (DCC), encoding the Netrin-1 receptor, may lead to mirror movements (MMs) associated with agenesis/dysgenesis of the corpus callosum (ACC) and cognitive and/or neuropsychiatric issues. The clinical phenotype is related to the biological function of DCC in the corpus callosum and corticospinal tract development as Netrin-1 is implicated in the guidance of developing axons toward the midline. We report on a child with a novel inherited, monoallelic, pathogenic variant in the DCC gene...
February 16, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38347594/single-molecule-imaging-of-tau-reveals-how-phosphorylation-affects-its-movement-and-confinement-in-living-cells
#3
JOURNAL ARTICLE
Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner, Jürgen Götz
Tau is a microtubule-associated protein that is regulated by post-translational modifications. The most studied of these modifications is phosphorylation, which affects Tau's aggregation and loss- and gain-of-functions, including the interaction with microtubules, in Alzheimer's disease and primary tauopathies. However, little is known about how Tau's phosphorylation state affects its dynamics and organisation at the single-molecule level. Here, using quantitative single-molecule localisation microscopy, we examined how mimicking or abrogating phosphorylation at 14 disease-associated serine and threonine residues through mutagenesis influences the behaviour of Tau in live Neuro-2a cells...
February 12, 2024: Molecular Brain
https://read.qxmd.com/read/38346889/persian-traffic-safety-and-health-cohort-a-population-based-precrash-cohort-study
#4
JOURNAL ARTICLE
Mina Golestani, Alireza Razzaghi, Mehdi Rezaei, Leila Vahedi, Faramarz Pourasghar, Mostafa Farahbakhsh, Alireza Shafiee-Kandjani, Mohammad Meshkini, Fatemeh Jahanjoo, Mir Bahador Yazdani, Elham Davtalab Esmaeili, Ali Jafari-Khounigh, Sajjad Ahmadi, Reza Mohammadi, Morteza Ghojazadeh, Homayoun Sadeghi-Bazargani
PURPOSE: Despite to high burden of road traffic injuries (RTIs), the RTI epidemiology has received less attention with rare investments on robust population cohorts. The PERSIAN Traffic Safety and Health Cohort (PTSHC) was designed to assess the potential causal relationships between human factors and RTI mortality, injuries, severity of the injury, hospitalised injury, violation of traffic law as well as offer the strongest scientific evidence. PARTICIPANTS: The precrash cohort study is carried out in four cities of Tabriz, Jolfa, Shabestar and Osku in East Azerbaijan province located in northwest Iran...
February 12, 2024: BMJ Open
https://read.qxmd.com/read/38335655/ameliorative-effects-of-vanillin-against-pentylenetetrazole-induced-epilepsy-and-associated-memory-loss-in-mice-the-role-of-nrf2-ho-1-nqo1-and-hmgb1-rage-tlr4-nf%C3%AE%C2%BAb-pathways
#5
JOURNAL ARTICLE
Mervt M Almostafa, Maged E Mohamed, Nancy S Younis
BACKGROUND: Epilepsy is a severe neurological disorder associated with substantial morbidity and mortality. Vanillin (Van) is a natural phenolic aldehyde with beneficial pharmacological properties. This study investigated the neuroprotective effects of Van in epilepsy and elucidated its mechanism of action. METHODS: Swiss albino mice were divided into the following five groups: "normal group", 0.9 % saline; "pentylenetetrazole (PTZ) group", intraperitoneal administration of 35 mg/kg PTZ on alternate days up to 42 days; and "PTZ + Van 20", "PTZ + Van 40", and "PTZ + sodium valproate (Val)" groups received PTZ injections in conjunction withVan 20 mg, Van 40 mg/kg, and Val 300 mg/kg, respectively...
February 8, 2024: International Immunopharmacology
https://read.qxmd.com/read/38321326/a-systematic-review-of-the-impact-of-brain-tumours-on-risk-of-motor-vehicle-crashes
#6
REVIEW
Sophie Tran, Adam Lapidus, Andrew Neal, Katherine B Peters, Lucy Gately, Malaka Ameratunga
PURPOSE: Brain tumours are associated with neurocognitive impairments that are important for safe driving. Driving is vital to maintaining patient autonomy, despite this there is limited research on driving capacity amongst patients with brain tumours. The purpose of this review is to examine MVC risk in patients with brain tumours to inform development of clearer driving guidelines. METHODS: A systematic review was performed using Medline and EMBASE. Observational studies were included...
February 6, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38313757/masseter-vestibular-evoked-myogenic-potentials-a-new-tool-to-assess-the-vestibulomasseteric-reflex-pathway
#7
REVIEW
Aishwarya Nagarajan, Sujeet Kumar Sinha
PURPOSE: This review article provides the readers with an in-depth insight in understanding and interpreting various research literatures on the masseter vestibular evoked myogenic potentials (mVEMP). The article also reviews the contemporary researches involving the clinical applications of the mVEMP. CONCLUSIONS: Masseter VEMP is an evolving yet clinically promising neuro-otology test tool that has recently gained more research interest and is considered an additional tool to diagnose various vestibular disorders...
January 2024: Journal of Otology
https://read.qxmd.com/read/38309329/atypical-alpha-band-microstates-produced-during-eyes-closed-resting-state-eeg-in-autism
#8
JOURNAL ARTICLE
Sushmit Das, Reza Zomorrodi, Melissa Kirkovski, Aron T Hill, Peter G Enticott, Daniel M Blumberger, Tarek K Rajji, Pushpal Desarkar
Electroencephalogram (EEG) microstates, which represent quasi-stable patterns of scalp topography, are a promising tool that has the temporal resolution to study atypical spatial and temporal networks in autism spectrum disorder (ASD). While current literature suggests microstates are atypical in ASD, their clinical utility, i.e., relationship with the core behavioural characteristics of ASD, is not fully understood. The aim of this study was to examine microstate parameters in ASD, and examine the relationship between these parameters and core behavioural characteristics in ASD...
February 1, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38296154/effects-of-the-pam-of-mglur2-jnj-46356479-on-brain-apoptotic-protein-levels-in-a-mouse-model-of-schizophrenia
#9
JOURNAL ARTICLE
David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Santiago Madero, Llucía Prohens, Irene Martínez-Serrano, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó
Current treatment for schizophrenia (SZ) ameliorates the positive symptoms, but is inefficient in treating the negative and cognitive symptoms. The SZ glutamatergic dysfunction hypothesis has opened new avenues in the development of novel drugs targeting the glutamate storm, an inducer of progressive neuropathological changes. Positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2), such as JNJ-46356479 (JNJ), reduce the presynaptic release of glutamate, which has previously been demonstrated to attenuate glutamate- and dopamine-induced apoptosis in human neuroblastoma cell cultures...
January 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38295426/tactile-stimulation-promotes-the-recovery-of%C3%A2-motor-function-in-rats-with-cerebral-ischaemia
#10
JOURNAL ARTICLE
Changkai Ke, Guangchen Yang, Heng Wang, Jiayi Hu, Chen Li, Chuan Huang, Chunxiao Wan
OBJECTIVES: Tactile stimulation (TS) can promote neurogenesis and motor function recovery in rats with hypoxic-ischaemic brain injury, but the underlying mechanism is not clear. This study aimed to assess the effects of TS on neurological function in rats after cerebral ischaemia and explore the underlying mechanism. METHODS: Adult SD rats were randomly divided into a sham operation (SHAM) group, middle cerebral artery occlusion with tactile stimulation (TS-MCAO) group and middle cerebral artery occlusion with sedentary intervention (SED-MCAO) group...
January 31, 2024: Neuro Endocrinology Letters
https://read.qxmd.com/read/38295424/exploring-self-care-within-the-context-of%C3%A2-cognitive-behavioural-therapy-and-supervision
#11
REVIEW
Jan Prasko, Marija Abeltina, Julija Gecaite-Stonciene, Julius Burkauskas, Ilona Krone, Erika Jurisova, Marta Zatkova, Jakub Vanek, Milos Slepecky, Marie Ociskova
This article emphasizes the critical role of self-care in the professional lives of cognitive behavioural therapy (CBT) therapists and supervisors. It delves into the importance of self-care, elucidating its significance in maintaining therapists' mental health and effectiveness. The article presents a range of practical strategies that promote self-care, providing therapists and supervisors with specific steps to incorporate self-care into their daily routines. Moreover, the article explores common challenges and barriers to self-care, such as a lack of time, feelings of guilt associated with prioritizing one's needs, and a lack of available resources for self-care...
January 31, 2024: Neuro Endocrinology Letters
https://read.qxmd.com/read/38290680/developmental-defects-in-cognition-metabolic-and-cardiac-function-following-maternal-exposures-to-low-environmental-levels-of-selective-serotonin-re-uptake-inhibitors-and-tributyltin-in-daphnia-magna
#12
JOURNAL ARTICLE
Hugo Moro, Demetrio Raldúa, Carlos Barata
Aquatic organisms are exposed to low concentrations of neuro-active chemicals, many of them acting also as neuroendocrine disruptors that can be hazardous during earlier embryonic stages. The present study aims to assess how exposure early in live to environmental low concentrations of two selective serotonin reuptake inhibitors (SSRIs), fluoxetine and sertraline, and tributyltin (TBT) affected cognitive, metabolic and cardiac responses in the model aquatic crustacean Daphnia magna. To that end, newly brooded females were exposed for an entire reproductive cycle (3-4 days) and the response of collected juveniles in the first, second and third consecutive broods, which were exposed, respectively, as embryos, provisioned and un-provisioned egg stages, was monitored...
January 28, 2024: Science of the Total Environment
https://read.qxmd.com/read/38287921/disruptive-consequences-of-monosodium-glutamate-on-male-reproductive-function-a-review
#13
REVIEW
David Tolulope Oluwole, Oladipupo Samuel Ebiwonjumi, Lydia Oluwatoyin Ajayi, Olubunmi Dupe Alabi, Victor Amos, Grace Akanbi, Wale Johnson Adeyemi, Ayodeji Folorunsho Ajayi
Monosodium glutamate (MSG) is one of the most extensively used flavour enhancers worldwide. Although it is widely regarded as a safe food additive with no recommended daily dosage, its over-consumption has been associated with notably pathophysiological events in various tissues and organs of the body. Previous studies have reported of the neuro- cardio- and hepato- toxic effects of its excessive exposure. Moreover, the food additive instigates metabolic dysfunction. It has been established that MSG damages male reproductive accessory organs like prostate glands and epididymis...
2024: Current research in toxicology
https://read.qxmd.com/read/38251069/neuro-orthopaedic-assessment-and-management-in-patients-with-prolonged-disorders-of-consciousness-a-review
#14
REVIEW
Aurore Thibaut, Marta Aloisi, Joëlle Dreessen, Naji Alnagger, Nicolas Lejeune, Rita Formisano
BACKGROUND: Following a severe acquired brain injury, neuro-orthopaedic disorders are commonplace. While these disorders can impact patients' functional recovery and quality of life, little is known regarding the assessment, management and treatment of neuro-orthopaedic disorders in patients with disorders of consciousness (DoC). OBJECTIVE: To describe neuro-orthopaedic disorders in the context of DoC and provide insights on their management and treatment. METHODS: A review of the literature was conducted focusing on neuro-orthopaedic disorders in patients with prolonged DoC...
2024: NeuroRehabilitation
https://read.qxmd.com/read/38246395/the-molecular-fingerprint-of-neuroinflammation-in-covid-19-a-comprehensive-discussion-on-molecular-mechanisms-of-neuroinflammation-due-to-sars-cov2-antigens
#15
REVIEW
Zeinab Deris Zayeri, Mehdi Torabizadeh, Masoud Kargar, Hashem Kazemi
BACKGROUND AND OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 attacks the neural system directly and indirectly via various systems, such as the nasal cavity, olfactory system, and facial nerves. Considering the high energy requirement, lack of antioxidant defenses, and high amounts of metal ions in the brain, oxidative damage is very harmful to the brain. Various neuropathic pain conditions, neurological disorders, and neuropsychiatric complications were reported in Coronavirus disease 2019, prolonged Coronavirus disease 2019, and after Coronavirus disease 2019 immunization...
January 19, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38244146/a-new-method-to-design-energy-conserving-surrogate-models-for-the-coupled-nonlinear-responses-of-intervertebral-discs
#16
JOURNAL ARTICLE
Maria Hammer, Tizian Wenzel, Gabriele Santin, Laura Meszaros-Beller, Judith Paige Little, Bernard Haasdonk, Syn Schmitt
The aim of this study was to design physics-preserving and precise surrogate models of the nonlinear elastic behaviour of an intervertebral disc (IVD). Based on artificial force-displacement data sets from detailed finite element (FE) disc models, we used greedy kernel and polynomial approximations of second, third and fourth order to train surrogate models for the scalar force-torque -potential. Doing so, the resulting models of the elastic IVD responses ensured the conservation of mechanical energy through their structure...
January 20, 2024: Biomechanics and Modeling in Mechanobiology
https://read.qxmd.com/read/38242425/increased-stress-vulnerability-in-the-offspring-of-socially-isolated-rats-behavioural-neurochemical-and-redox-dysfunctions
#17
JOURNAL ARTICLE
Maria Bove, Maria Grazia Morgese, Stefania Dimonte, Vladyslav Sikora, Lisa Pia Agosti, Maria Adelaide Palmieri, Paolo Tucci, Stefania Schiavone, Luigia Trabace
Stressful events during pregnancy impact on the progeny neurodevelopment. However, little is known about preconceptional stress effects. The rat social isolation represents an animal model of chronic stress inducing a variety of dysfunctions. Moreover, social deprivation during adolescence interferes with key neurodevelopmental processes. Here, we investigated the development of behavioural, neurochemical and redox alterations in the male offspring of socially isolated female rats before pregnancy, reared in group (GRP) or in social isolation (ISO) from weaning until young-adulthood...
January 17, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38241230/environmental-enrichment-improves-social-isolation-induced-memory-impairment-the-possible-role-of-itsn1-reelin-ampa-receptor-signaling-pathway
#18
JOURNAL ARTICLE
Swamynathan Sowndharya, Koilmani Emmanuvel Rajan
Environmental enrichment (EE) through combination of social and non-biological stimuli enhances activity-dependent synaptic plasticity and improves behavioural performance. Our earlier studies have suggested that EE resilience the stress induced depression/ anxiety-like behaviour in Indian field mice Mus booduga. This study was designed to test whether EE reverses the social isolation (SI) induced effect and improve memory. Field-caught mice M. booduga were subjected to behaviour test (Direct wild, DW), remaining animals were housed under SI for ten days and then housed for short-term at standard condition (STSC)/ long-term at standard condition (LTSC) or as group in EE cage...
2024: PloS One
https://read.qxmd.com/read/38228265/daphnia-magna-an-emerging-environmental-model-of-neuro-and-cardiotoxicity-of-illicit-drugs
#19
JOURNAL ARTICLE
Marina Bellot, Fernando Soria, Raul López-Arnau, Cristian Gómez-Canela, Carlos Barata
Cocaine, methamphetamine, ectasy (3,4-methylenedioxy amphetamine (MDMA)) and ketamine are among the most consumed drugs worldwide causing cognitive, oxidative stress and cardiovascular problems in humans. Residue levels of these drugs and their transformation products may still enter the aquatic environment, where concentrations up to hundreds of ng/L have been measured. In the present work we tested the hypothesis that psychotropic effects and the mode of action of these drugs in D. magna cognitive, oxidative stress and cardiovascular responses are equivalent to those reported in humans and other vertebrate models...
January 14, 2024: Environmental Pollution
https://read.qxmd.com/read/38168729/long-term-antipsychotic-use-orthostatic-hypotension-and-falls-in-older-adults-with-alzheimer-s-disease
#20
JOURNAL ARTICLE
Adam H Dyer, Claire Murphy, Helena Dolphin, Laura Morrison, Robert Briggs, Brian Lawlor, Sean P Kennelly
PURPOSE: Antipsychotic use in Alzheimer disease (AD) is associated with adverse events and mortality. Whilst postulated to cause/exacerbate orthostatic hypotension (OH), the exact relationship between antipsychotic use and OH has never been explored in AD-a group who are particularly vulnerable to neuro-cardiovascular instability and adverse effects of medication on orthostatic blood pressure (BP) behaviour. METHODS: We analysed longitudinal data from an 18-month trial of Nilvadipine in mild-moderate AD...
January 2, 2024: European Geriatric Medicine
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