keyword
MENU ▼
Read by QxMD icon Read
search

Single-photon

keyword
https://www.readbyqxmd.com/read/28525823/development-and-validation-of-a-reversed-phase-hplc-method-for-analysis-of-radiochemical-purity-in-123-i-ibzm
#1
Shiou-Shiow Farn, Yuen-Han Yeh, Chang-Chin Li, Ching-Shiuann Yang, Jenn-Tzong Chen, Chung-Shan Yu, Wuu-Jyh Lin
[(123)I]IBZM is used widely for in vivo imaging of D2 receptors in human brain and shows relatively fast kinetics and a greater susceptibility to synaptic dopamine release than other single-photon emission computed tomography (SPECT) radioligands. A reliable and reversed-phase HPLC method using UV/VIS and radiometric detectors has been developed for qualitative analysis of BZM and IBZM and radiochemical purity in [(123)I]IBZM preparations. The method uses gradient elution on a Zorbax XDB C-18 column with a mobile phase that consists of 10mM 3,3-dimethylglutaric acid (DMGA), pH 7...
April 15, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28524118/novel-radiolabeled-bisphosphonates-for-pet-diagnosis-and-endoradiotherapy-of-bone-metastases
#2
REVIEW
Nina Pfannkuchen, Marian Meckel, Ralf Bergmann, Michael Bachmann, Chandrasekhar Bal, Mike Sathekge, Wolfgang Mohnike, Richard P Baum, Frank Rösch
Bone metastases, often a consequence of breast, prostate, and lung carcinomas, are characterized by an increased bone turnover, which can be visualized by positron emission tomography (PET), as well as single-photon emission computed tomography (SPECT). Bisphosphonate complexes of (99m)Tc are predominantly used as SPECT tracers. In contrast to SPECT, PET offers a higher spatial resolution and, owing to the (68)Ge/(68)Ga generator, an analog to the established (99m)Tc generator exists. Complexation of Ga(III) requires the use of chelators...
May 18, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28524076/-18-f-fluorinated-carboplatin-and-111-in-liposome-for-image-guided-drug-delivery
#3
Narottam Lamichhane, Gajanan K Dewkar, Gobalakrishnan Sundaresan, Rebecca N Mahon, Jamal Zweit
Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [(111)In]-Liposome as a drug delivery vehicle, encapsulating a novel (18)F-labeled carboplatin drug derivative ([(18)F]-FCP) as a dual-molecular imaging tool as both a radiolabeled drug and radiolabeled carrier. The approach has the potential for clinical translation in individual patients using a dual modal approach of clinically-relevant radionuclides of (18)F positron emission tomography (PET) and (111)In single photon emission computed tomography (SPECT)...
May 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28522868/first-demonstration-of-multi-color-3-d-in-vivo-imaging-using-ultra-compact-compton-camera
#4
Aya Kishimoto, Jun Kataoka, Takanori Taya, Leo Tagawa, Saku Mochizuki, Shinji Ohsuka, Yuto Nagao, Keisuke Kurita, Mitsutaka Yamaguchi, Naoki Kawachi, Keiko Matsunaga, Hayato Ikeda, Eku Shimosegawa, Jun Hatazawa
In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522739/imaging-macrophage-accumulation-in-a-murine-model-of-chronic-pancreatitis-with-125-i-iododpa-spect-ct
#5
Catherine A Foss, Liansheng Liu, Ronnie C Mease, Haofan Wang, Pankaj Pasricha, Martin G Pomper
Background and Aims: Pancreatitis remains a diagnostic challenge in patients with mild to moderate disease, with current imaging modalities inadequate. Given the prominent macrophage infiltrate in chronic pancreatitis, we hypothesized that (125)I-iodo-DPA-713 (iodoDPA), a small-molecule radiotracer that specifically targets macrophages, could be used with single photon emission computed tomography-computed tomography (SPECT-CT) to image pancreatic inflammation in a relevant experimental model. Methods: Chronic pancreatitis was induced in C57BL/6 mice with cerulein and were contrasted with vehicle-injected controls...
May 18, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28522082/brain-perfusion-during-rapid-eye-movement-sleep-successfully-identifies-amnestic-mild-cognitive-impairment
#6
Pauline Brayet, Dominique Petit, Andrée-Ann Baril, Nadia Gosselin, Jean-François Gagnon, Jean-Paul Soucy, Serge Gauthier, Marie-Jeanne Kergoat, Julie Carrier, Isabelle Rouleau, Jacques Montplaisir
INTRODUCTION: Prodromal markers of Alzheimer's disease (AD) have been derived from wakefulness. However, brain perfusion during rapid-eye movement (REM) sleep could be a sensitive marker of amnestic mild cognitive impairment (aMCI), as activation of REM sleep relies more on the cholinergic system. METHODS: Eight subjects with aMCI, and 16 controls, underwent two single-photon emission computed tomography (SPECT) scans with tracer injected during REM sleep then wakefulness...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28520803/multiple-modality-biomarker-prediction-of-cognitive-impairment-in-prospectively-followed-de-novo-parkinson-disease
#7
Chelsea Caspell-Garcia, Tanya Simuni, Duygu Tosun-Turgut, I-Wei Wu, Yu Zhang, Mike Nalls, Andrew Singleton, Leslie A Shaw, Ju-Hee Kang, John Q Trojanowski, Andrew Siderowf, Christopher Coffey, Shirley Lasch, Dag Aarsland, David Burn, Lana M Chahine, Alberto J Espay, Eric D Foster, Keith A Hawkins, Irene Litvan, Irene Richard, Daniel Weintraub
OBJECTIVES: To assess the neurobiological substrate of initial cognitive decline in Parkinson's disease (PD) to inform patient management, clinical trial design, and development of treatments. METHODS: We longitudinally assessed, up to 3 years, 423 newly diagnosed patients with idiopathic PD, untreated at baseline, from 33 international movement disorder centers. Study outcomes were four determinations of cognitive impairment or decline, and biomarker predictors were baseline dopamine transporter (DAT) single photon emission computed tomography (SPECT) scan, structural magnetic resonance imaging (MRI; volume and thickness), diffusion tensor imaging (mean diffusivity and fractional anisotropy), cerebrospinal fluid (CSF; amyloid beta [Aβ], tau and alpha synuclein), and 11 single nucleotide polymorphisms (SNPs) previously associated with PD cognition...
2017: PloS One
https://www.readbyqxmd.com/read/28520430/fluorescence-dynamics-of-a-fret-probe-designed-for-crowding-studies
#8
Megan Currie, Hannah Leopold, Jacob Schwarz, Arnold J Boersma, Erin D Sheets, Ahmed A Heikal
Living cells are crowded with macromolecules and organelles. As a result, there is an urgent need for molecular sensors for quantitative, site-specific assessment of the macromolecular crowding effects on a myriad of biochemical processes towards quantitative cell biology and biophysics. Here we investigate the excited-state dynamics and translational diffusion of a novel FRET sensor (mCerulean-linker-mCitrine) in a buffer (PBS, pH 7.4) at room temperature. Complementary experiments were carried out on free CFP, YFP, and the cleaved FRET probe as controls...
May 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28518023/zika-virus-associated-cognitive-impairment-in-adolescent-2016
#9
Jason Zucker, Natalie Neu, Claudia A Chiriboga, Veronica J Hinton, Marc Leonardo, Arif Sheikh, Kiran Thakur
Incidence of neurologic manifestations associated with Zika virus infection has been increasing. In 2016, neuropsychological and cognitive changes developed in an adolescent after travel to a Zika virus-endemic area. Single-photon emission computed tomography and neuropsychological testing raised the possibility that Zika virus infection may lead to neuropsychiatric and cognitive symptoms.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28515582/evaluation-of-mr-perfusion-abnormalities-in-organophosphorus-poisoning-and-its-correlation-with-spect
#10
K Uday Bhanu, Niranjan Khandelwal, Sameer Vyas, Paramjeet Singh, Anuj Prabhakar, B R Mittal, Ashish Bhalla
AIM: Acute organophosphate (OP) pesticide poisoning causes substantial morbidity and mortality worldwide. Many imaging modalities, such as computerized tomography (CT), magnetic resonance imaging (MRI), and single photon emission computed tomography (SPECT) of the brain, have been used for quantitative assessment of the acute brain insult caused by acute OP poisoning. Perfusion defects on SPECT in acutely poisoned patients with OPs have been described, however, MR perfusion abnormalities have not been described in the literature...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28514394/-the-diagnostic-value-of-measuring-the-momentary-blood-flow-reserve-versus-non-invasive-methods-to-detect-myocardial-ischemia-in-assessing-the-functional-significance-of-borderline-coronary-artery-stenoses
#11
D I Darensky, V V Gramovich, E A Zharova, A A Ansheles, V B Sergienko, M G Mitroshkin, R V Atanesyan, Yu G Matchin
AIM: To estimate the diagnostic value of measuring the momentary blood flow reserve (MBFR) versus the surrogate non-invasive standard (SNS) for myocardial ischemia verification (MIV) (a combination of stress echocardiography and single-photon emission computed tomography). SUBJECTS AND METHODS: The investigation enrolled 50 patients with stable angina in the presence of chronic coronary heart disease (CHD) or suspected CHD, in whom coronary angiography (CA) revealed borderline coronary stenoses (50-70% lumen diameters)...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28514229/an-open-source-wireless-capable-miniature-microscope-system
#12
William A Liberti, L Nathan Perkins, Daniel P Leman, Timothy J Gardner
OBJECTIVE: Fluorescence imaging through head-mounted microscopes in freely behaving animals is becoming a standard method to study neural circuit function. Flexible, open-source designs are needed to spur evolution of the method. APPROACH: We describe a miniature microscope for single-photon fluorescence imaging in freely behaving animals. The device is made from 3D printed parts and off-the-shelf components. These microscopes weigh less than 1.8 g, can be configured to image a variety of fluorophores, and can be used wirelessly or in conjunction with active commutators...
May 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28509077/relationships-between-cognitive-impairment-on-adas-cog-and-regional-cerebral-blood-flow-using-spect-in-late-onset-alzheimer-s-disease
#13
Michio Takahashi, Yasunori Oda, Toshiyuki Okubo, Yukihiko Shirayama
The aim of this study was to examine brain hypoperfusion and its relationship with cognitive dysfunction in late-onset Alzheimer's disease (AD). Forty patients with late-onset AD and not receiving acetylcholinesterase inhibitors were recruited from outpatient clinics. We examined cognitive function using the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and brain perfusion using single-photon emission computed tomography, and analyzed classified gyrus level segments with three-dimensional stereotactic surface projection and the stereotactic extraction estimation method level 3...
May 16, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28508491/implementation-of-absolute-quantification-in-small-animal-spect-imaging-phantom-and-animal-studies
#14
Shabnam Khorasani Gerdekoohi, Naser Vosoughi, Kaveh Tanha, Majid Assadi, Pardis Ghafarian, Arman Rahmim, Mohammad Reza Ay
PURPOSE: Presence of photon attenuation severely challenges quantitative accuracy in single-photon emission computed tomography (SPECT) imaging. Subsequently, various attenuation correction methods have been developed to compensate for this degradation. The present study aims to implement an attenuation correction method and then to evaluate quantification accuracy of attenuation correction in small-animal SPECT imaging. METHODS: Images were reconstructed using an iterative reconstruction method based on the maximum-likelihood expectation maximization (MLEM) algorithm including resolution recovery...
May 16, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28507332/a-solid-state-single-photon-filter
#15
Lorenzo De Santis, Carlos Antón, Bogdan Reznychenko, Niccolo Somaschi, Guillaume Coppola, Jean Senellart, Carmen Gómez, Aristide Lemaître, Isabelle Sagnes, Andrew G White, Loïc Lanco, Alexia Auffèves, Pascale Senellart
A strong limitation of linear optical quantum computing is the probabilistic operation of two-quantum-bit gates based on the coalescence of indistinguishable photons. A route to deterministic operation is to exploit the single-photon nonlinearity of an atomic transition. Through engineering of the atom-photon interaction, phase shifters, photon filters and photon-photon gates have been demonstrated with natural atoms. Proofs of concept have been reported with semiconductor quantum dots, yet limited by inefficient atom-photon interfaces and dephasing...
May 15, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28504798/a-vacuum-ultraviolet-photoionization-study-on-high-temperature-decomposition-of-jp-10-exo-tetrahydrodicyclopentadiene
#16
Long Zhao, Tao Yang, Ralf I Kaiser, Tyler P Troy, Bo Xu, Musahid Ahmed, Juan Alarcon, Daniel Belisario-Lara, Alexander M Mebel, Yan Zhang, Chuangchuang Cao, Jiabiao Zou
Two sets of experiments were performed to unravel the high-temperature pyrolysis of tricyclo[5.2.1.0(2,6)] decane (JP-10) exploiting high-temperature reactors over a temperature range of 1100 K to 1600 K, Advanced Light Source (ALS), and 927 K to 1083 K, National Synchrotron Radiation Laboratory (NSRL), with residence times of a few tens of microseconds (ALS) to typically 144 ms (NSRL). The products were identified in situ in supersonic molecular beams via single photon vacuum ultraviolet (VUV) photoionization coupled with mass spectroscopic detection in a reflectron time-of-flight mass spectrometer (ReTOF)...
May 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28504244/mid-infrared-coincidence-measurements-on-twin-photons-at-room-temperature
#17
M Mancinelli, A Trenti, S Piccione, G Fontana, J S Dam, P Tidemand-Lichtenberg, C Pedersen, L Pavesi
Quantum measurements using single-photon detectors are opening interesting new perspectives in diverse fields such as remote sensing, quantum cryptography and quantum computing. A particularly demanding class of applications relies on the simultaneous detection of correlated single photons. In the visible and near infrared wavelength ranges suitable single-photon detectors do exist. However, low detector quantum efficiency or excessive noise has hampered their mid-infrared (MIR) counterpart. Fast and highly efficient single-photon detectors are thus highly sought after for MIR applications...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28503388/pilot-study-of-99mtc-labeled-ethylene-dicysteine-deoxyglucose-spect-ct-imaging-in-treatment-response-evaluation-in-patients-with-locally-advanced-head-and-neck-cancer
#18
Daniel T Ginat, Charles Westiin, Ryan J Brisson, Chen-Tu Chin, Yonglin Pu, Hannah Zhang, Jonas A De Souza
BACKGROUND: The purpose of this study is to describe the preliminary findings of 99mTc-labeled ethylene dicysteine deoxyglucose (99mTc-EC-DG) performed four weeks after chemoradiotherapy in patients with locally advanced head and neck squamous cell carcinoma. METHODS: Review of nine patients with locally advanced head and neck squamous cell carcinomas imaged with 99mTc-EC-DG single photon emission computed tomography-computed tomography (SPECT-CT) at baseline before treatment and at four weeks after treatment completion was performed...
April 11, 2017: Curēus
https://www.readbyqxmd.com/read/28499601/multicomponent-nanocrystals-with-anti-stokes-luminescence-as-contrast-agents-for-modern-imaging-techniques
#19
REVIEW
A N Generalova, B N Chichkov, E V Khaydukov
Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry...
May 4, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28498703/realization-of-a-cascaded-quantum-system-heralded-absorption-of-a-single-photon-qubit-by-a-single-electron-charged-quantum-dot
#20
Aymeric Delteil, Zhe Sun, Stefan Fält, Atac Imamoğlu
Photonic losses pose a major limitation for the implementation of a quantum state transfer between nodes of a quantum network. A measurement that heralds a successful transfer without revealing any information about the qubit may alleviate this limitation. Here, we demonstrate the heralded absorption of a single photonic qubit, generated by a single neutral quantum dot, by a single-electron charged quantum dot that is located 5 m away. The transfer of quantum information to the spin degree of freedom takes place upon the emission of a photon; for a properly chosen or prepared quantum dot, the detection of this photon yields no information about the qubit...
April 28, 2017: Physical Review Letters
keyword
keyword
94411
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"