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https://www.readbyqxmd.com/read/29346173/the-subresolution-datscan-phantom-a-cost-effective-flexible-alternative-to-traditional-phantom-technology
#1
Jonathan C Taylor, Nicholas Vennart, Ian Negus, Robin Holmes, Oliver Bandmann, Christine Lo, John Fenner
The Alderson striatal phantom is frequently used to assess I-FP-CIT (Ioflupane) image quality and to test semi-quantification software. However, its design is associated with a number of limitations, in particular: unrealistic image appearances and inflexibility. A new physical phantom approach is proposed on the basis of subresolution phantom technology. The design incorporates thin slabs of attenuating material generated through additive manufacturing, and paper sheets with radioactive ink patterns printed on their surface, created with a conventional inkjet printer...
January 17, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29344922/impact-of-renin-angiotensin-aldosterone-system-polymorphisms-on-myocardial-perfusion-correlations-with-myocardial-single-photon-emission-computed-tomography-derived-parameters
#2
George Angelidis, Maria Samara, Maria Papathanassiou, Maria Satra, Varvara Valotassiou, Ioannis Tsougos, Dimitrios Psimadas, Chara Tzavara, Sotiria Alexiou, John Koutsikos, Nikolaos Demakopoulos, Gregory Giamouzis, Filippos Triposkiadis, John Skoularigis, Panagoula Kollia, Panagiotis Georgoulias
BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) has an important role in atherosclerosis. We investigated the effects of six RAAS gene polymorphisms on myocardial perfusion. METHODS AND RESULTS: We examined 810 patients with known or suspected coronary artery disease (CAD) using stress-rest myocardial single-photon emission computed tomography. Summed stress score (SSS), summed rest score (SRS), summed difference score (SDS), transient ischemic dilation (TID), and lung/heart ratio (LHR) were recorded...
January 17, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29344917/non-cardiac-uptake-of-technetium-99m-pyrophosphate-in-transthyretin-cardiac-amyloidosis
#3
Brett W Sperry, Matthew H Gonzalez, Richard Brunken, Manuel D Cerqueira, Mazen Hanna, Wael A Jaber
BACKGROUND: Technetium-based bone scintigraphy is rapidly becoming the most common non-invasive imaging tool in the diagnosis of Transthyretin cardiac amyloidosis (ATTR). Skeletal muscle uptake has been described with technetium-99m-3,3-diphosphono-1,2-propanodicarboxylic acid (TcDPD), and may account for masking of bony uptake. We sought to investigate skeletal muscle uptake of technetium-99m-pyrophosphate (TcPYP) in patients with ATTR. METHODS AND RESULTS: This was a retrospective analysis of 57 patients diagnosed with ATTR who underwent TcPYP scintigraphy...
January 17, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29344827/molecular-imaging-of-cardiac-remodelling-after-myocardial-infarction
#4
REVIEW
Daniel Curley, Begoña Lavin Plaza, Ajay M Shah, René M Botnar
Myocardial infarction and subsequent heart failure is a major health burden associated with significant mortality and morbidity in western societies. The ability of cardiac tissue to recover after myocardial infarction is affected by numerous complex cellular and molecular pathways. Unbalance or failure of these pathways can lead to adverse remodelling of the heart and poor prognosis. Current clinical cardiac imaging modalities assess anatomy, perfusion, function, and viability of the myocardium, yet do not offer any insight into the specific molecular pathways involved in the repair process...
January 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29344519/icg-clearance-test-and-99mtc-gsa-spect-ct-fusion-images
#5
REVIEW
Yuji Iimuro
Preoperative estimation of future remnant liver function is critical for major hepatic surgery to avoid postoperative morbidity and mortality. Among several liver function tests, the indocyanine green (ICG) clearance test is still the most popular dynamic method. The usefulness of ICG clearance test parameters, such as ICGR15, KICG, or PDRICG, has been reported by many investigators. The transcutaneous non-invasive pulse dye densitometry system has made the ICG clearance test more convenient and attractive, even in Western countries...
December 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29344306/131i-labeled-copper-sulfide-loaded-microspheres-to-treat-hepatic-tumors-via-hepatic-artery-embolization
#6
Qiufang Liu, Yuyi Qian, Panli Li, Sihang Zhang, Jianjun Liu, Xiaoguang Sun, Michael Fulham, Dagan Feng, Gang Huang, Wei Lu, Shaoli Song
Purpose: Transcatheter hepatic artery embolization therapy is a minimally invasive alternative for treating inoperable liver cancer but recurrence is frequent. Multifunctional agents, however, offer an opportunity for tumor eradication. In this study, we were aim to synthesized poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating hollow CuS nanoparticles (HCuSNPs) and paclitaxel (PTX) that were then labeled with radioiodine-131 (131I) to produce 131I-HCuSNPs-MS-PTX. This compound combines the multi-theranostic properties of chemotherapy, radiotherapy and photothermal therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29341760/correlated-photon-dynamics-in-dissipative-rydberg-media
#7
Emil Zeuthen, Michael J Gullans, Mohammad F Maghrebi, Alexey V Gorshkov
Rydberg blockade physics in optically dense atomic media under the conditions of electromagnetically induced transparency (EIT) leads to strong dissipative interactions between single photons. We introduce a new approach to analyzing this challenging many-body problem in the limit of a large optical depth per blockade radius. In our approach, we separate the single-polariton EIT physics from Rydberg-Rydberg interactions in a serialized manner while using a hard-sphere model for the latter, thus capturing the dualistic particle-wave nature of light as it manifests itself in dissipative Rydberg-EIT media...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341719/detecting-topological-invariants-in-nonunitary-discrete-time-quantum-walks
#8
Xiang Zhan, Lei Xiao, Zhihao Bian, Kunkun Wang, Xingze Qiu, Barry C Sanders, Wei Yi, Peng Xue
We report the experimental detection of bulk topological invariants in nonunitary discrete-time quantum walks with single photons. The nonunitarity of the quantum dynamics is enforced by periodically performing partial measurements on the polarization of the walker photon, which effectively introduces loss to the dynamics. The topological invariant of the nonunitary quantum walk is manifested in the quantized average displacement of the walker, which is probed by monitoring the photon loss. We confirm the topological properties of the system by observing localized edge states at the boundary of regions with different topological invariants...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341718/search-for-invisible-decays-of-a-dark-photon-produced-in-e-e-collisions-at-babar
#9
J P Lees, V Poireau, V Tisserand, E Grauges, A Palano, G Eigen, D N Brown, M Derdzinski, A Giuffrida, Yu G Kolomensky, M Fritsch, H Koch, T Schroeder, C Hearty, T S Mattison, J A McKenna, R Y So, V E Blinov, A R Buzykaev, V P Druzhinin, V B Golubev, E A Kravchenko, A P Onuchin, S I Serednyakov, Yu I Skovpen, E P Solodov, K Yu Todyshev, A J Lankford, J W Gary, O Long, A M Eisner, W S Lockman, W Panduro Vazquez, D S Chao, C H Cheng, B Echenard, K T Flood, D G Hitlin, J Kim, T S Miyashita, P Ongmongkolkul, F C Porter, M Röhrken, Z Huard, B T Meadows, B G Pushpawela, M D Sokoloff, L Sun, J G Smith, S R Wagner, D Bernard, M Verderi, D Bettoni, C Bozzi, R Calabrese, G Cibinetto, E Fioravanti, I Garzia, E Luppi, V Santoro, A Calcaterra, R de Sangro, G Finocchiaro, S Martellotti, P Patteri, I M Peruzzi, M Piccolo, M Rotondo, A Zallo, S Passaggio, C Patrignani, H M Lacker, B Bhuyan, U Mallik, C Chen, J Cochran, S Prell, H Ahmed, A V Gritsan, N Arnaud, M Davier, F Le Diberder, A M Lutz, G Wormser, D J Lange, D M Wright, J P Coleman, E Gabathuler, D E Hutchcroft, D J Payne, C Touramanis, A J Bevan, F Di Lodovico, R Sacco, G Cowan, Sw Banerjee, D N Brown, C L Davis, A G Denig, W Gradl, K Griessinger, A Hafner, K R Schubert, R J Barlow, G D Lafferty, R Cenci, A Jawahery, D A Roberts, R Cowan, S H Robertson, B Dey, N Neri, F Palombo, R Cheaib, L Cremaldi, R Godang, D J Summers, P Taras, G De Nardo, C Sciacca, G Raven, C P Jessop, J M LoSecco, K Honscheid, R Kass, A Gaz, M Margoni, M Posocco, G Simi, F Simonetto, R Stroili, S Akar, E Ben-Haim, M Bomben, G R Bonneaud, G Calderini, J Chauveau, G Marchiori, J Ocariz, M Biasini, E Manoni, A Rossi, G Batignani, S Bettarini, M Carpinelli, G Casarosa, M Chrzaszcz, F Forti, M A Giorgi, A Lusiani, B Oberhof, E Paoloni, M Rama, G Rizzo, J J Walsh, A J S Smith, F Anulli, R Faccini, F Ferrarotto, F Ferroni, A Pilloni, G Piredda, C Bünger, S Dittrich, O Grünberg, M Heß, T Leddig, C Voß, R Waldi, T Adye, F F Wilson, S Emery, G Vasseur, D Aston, C Cartaro, M R Convery, J Dorfan, W Dunwoodie, M Ebert, R C Field, B G Fulsom, M T Graham, C Hast, W R Innes, P Kim, D W G S Leith, S Luitz, D B MacFarlane, D R Muller, H Neal, B N Ratcliff, A Roodman, M K Sullivan, J Va'vra, W J Wisniewski, M V Purohit, J R Wilson, A Randle-Conde, S J Sekula, M Bellis, P R Burchat, E M T Puccio, M S Alam, J A Ernst, R Gorodeisky, N Guttman, D R Peimer, A Soffer, S M Spanier, J L Ritchie, R F Schwitters, J M Izen, X C Lou, F Bianchi, F De Mori, A Filippi, D Gamba, L Lanceri, L Vitale, F Martinez-Vidal, A Oyanguren, J Albert, A Beaulieu, F U Bernlochner, G J King, R Kowalewski, T Lueck, I M Nugent, J M Roney, R J Sobie, N Tasneem, T J Gershon, P F Harrison, T E Latham, R Prepost, S L Wu
We search for single-photon events in 53  fb^{-1} of e^{+}e^{-} collision data collected with the BABAR detector at the PEP-II B-Factory. We look for events with a single high-energy photon and a large missing momentum and energy, consistent with production of a spin-1 particle A^{'} through the process e^{+}e^{-}→γA^{'}; A^{'}→invisible. Such particles, referred to as "dark photons," are motivated by theories applying a U(1) gauge symmetry to dark matter. We find no evidence for such processes and set 90% confidence level upper limits on the coupling strength of A^{'} to e^{+}e^{-} in the mass range m_{A^{'}}≤8  GeV...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341716/single-electron-and-single-photon-sensitivity-with-a-silicon-skipper-ccd
#10
Javier Tiffenberg, Miguel Sofo-Haro, Alex Drlica-Wagner, Rouven Essig, Yann Guardincerri, Steve Holland, Tomer Volansky, Tien-Tien Yu
We have developed ultralow-noise electronics in combination with repetitive, nondestructive readout of a thick, fully depleted charge-coupled device (CCD) to achieve an unprecedented noise level of 0.068  e^{-} rms/pixel. This is the first time that discrete subelectron readout noise has been achieved reproducible over millions of pixels on a stable, large-area detector. This enables the contemporaneous, discrete, and quantized measurement of charge in pixels, irrespective of whether they contain zero electrons or thousands of electrons...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341675/many-molecule-reaction-triggered-by-a-single-photon-in-polaritonic-chemistry
#11
Javier Galego, Francisco J Garcia-Vidal, Johannes Feist
The second law of photochemistry states that, in most cases, no more than one molecule is activated for an excited-state reaction for each photon absorbed by a collection of molecules. In this Letter, we demonstrate that it is possible to trigger a many-molecule reaction using only one photon by strongly coupling the molecular ensemble to a confined light mode. The collective nature of the resulting hybrid states of the system (the so-called polaritons) leads to the formation of a polaritonic "supermolecule" involving the degrees of freedom of all molecules, opening a reaction path on which all involved molecules undergo a chemical transformation...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341024/advanced-contrast-agents-for-multimodal-biomedical-imaging-based-on-nanotechnology
#12
Daniel Calle, Paloma Ballesteros, Sebastián Cerdán
Clinical imaging modalities have reached a prominent role in medical diagnosis and patient management in the last decades. Different image methodologies as Positron Emission Tomography, Single Photon Emission Tomography, X-Rays, or Magnetic Resonance Imaging are in continuous evolution to satisfy the increasing demands of current medical diagnosis. Progress in these methodologies has been favored by the parallel development of increasingly more powerful contrast agents. These are molecules that enhance the intrinsic contrast of the images in the tissues where they accumulate, revealing noninvasively the presence of characteristic molecular targets or differential physiopathological microenvironments...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29340889/quantification-of-myocardial-perfusion-defect-size-in-rats-comparison-between-quantitative-perfusion-spect-and-autoradiography
#13
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Tomo Hiromasa, Koichi Okuda, Takayuki Shibutani, Kazuhiro Shiba, Seigo Kinuya
PURPOSE: Ultra-high resolution single-photon emission computed tomography (SPECT) system, using multiple pinhole collimators, has been applied to the imaging of small rodents. We aimed to compare the myocardial infarction (MI) area on quantitative perfusion single-photon emission computed tomography (QPS; Cedars-Sinai Medical Center, USA) with that on high-resolution autoradiography in rat model to determine the accuracy of perfusion defect measurement by QPS. PROCEDURES: After thoracotomy, rats (n = 9) had their left coronary arteries occluded and reperfused before injection with 185 MBq [99mTc] methoxyisobutylisonitrile ([99mTc]MIBI) for SPECT and autoradiography...
January 16, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29340757/comparing-brain-activity-patterns-during-spontaneous-exploratory-and-cue-instructed-learning-using-single-photon-emission-computed-tomography-spect-imaging-of-regional-cerebral-blood-flow-in-freely-behaving-rats
#14
A Mannewitz, J Bock, S Kreitz, A Hess, J Goldschmidt, H Scheich, Katharina Braun
Learning can be categorized into cue-instructed and spontaneous learning types; however, so far, there is no detailed comparative analysis of specific brain pathways involved in these learning types. The aim of this study was to compare brain activity patterns during these learning tasks using the in vivo imaging technique of single photon-emission computed tomography (SPECT) of regional cerebral blood flow (rCBF). During spontaneous exploratory learning, higher levels of rCBF compared to cue-instructed learning were observed in motor control regions, including specific subregions of the motor cortex and the striatum, as well as in regions of sensory pathways including olfactory, somatosensory, and visual modalities...
January 16, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29339678/endarteritis-of-coarctation-of-the-aorta-diagnosed-with-pet-ct
#15
Ümit Yaşar Sinan, Burcu Dirlik Serim, Rukiye Yıldırım, Özge Çetinarslan, Mehmet Serdar Küçükoğlu
Infective endocarditis (IE) is an infectious disease that affects the endothelium of the large intrathoracic vessels, heart valves, and intra-cardiac foreign body material. A 20-year-old woman was admitted to the cardiology department with complaints of fever and palpitations. Transthoracic echocardiography revealed a bicuspid aortic valve, aortic root enlargement, and aortic coarctation. Transesophageal echocardiography revealed a bicuspid aortic valve, but there was no vegetation. Methicillin-sensitive Staphylococcus aureus was identified on a blood culture...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29339550/relative-target-affinities-of-t-cell-dependent-bispecific-antibodies-determine-biodistribution-in-a-solid-tumor-mouse-model
#16
Danielle Mandikian, Nene Takahashi, Amy A Lo, Ji Li, Jeffrey Eastham-Anderson, Dionysos Slaga, Jason Ho, Maria Hristopoulos, Robyn Clark, Klara Totpal, Kedan Lin, Sean B Joseph, Mark S Dennis, Saileta Prabhu, Teemu T Junttila, C Andrew Boswell
Anti-HER2/CD3, a T cell-dependent bispecific antibody (TDB) construct, induces T cell-mediated cell death in cancer cells expressing HER2 by cross-linking tumor HER2 with CD3 on cytotoxic T cells, thereby creating a functional cytolytic synapse. TDB design is a very challenging process that requires consideration of multiple parameters. While therapeutic antibody design strategy is commonly driven by striving for the highest attainable antigen binding affinity, little is known about how the affinity of each TDB arm can affect the targeting ability of the other arm and the consequent distribution and efficacy...
January 16, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29333471/sectional-anatomy-quiz-ii
#17
Rashid Hashmi
This mage-based series comprises of a quiz pertaining to the identification of salient and important anatomical structures and landmarks expected to be seen at a given level on the computed tomography (CT). The representative image is followed by a series of images showing the examples of different commonly encountered pathological entities that can be seen at this level in a routine clinical practice. Readers are encouraged to identify the highlighted anatomical structures and landmarks in all the images and appreciate the alterations in the appearance of the normal structures resulting from the presence of a pathology...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333467/a-simple-non-invasive-i-123-imp-autoradiography-method-developed-by-modifying-the-simple-non-invasive-i-123-imp-microsphere-method
#18
Asato Ofuji, Rieko Nagaoka, Kosuke Yamashita, Akihiro Takaki, Shigeki Ito
Objectives: We developed a simple non-invasive I-123-N-isopropyl-p-iodoamphetamine (123I-IMP) quantification method by analyzing chest RI-angiography and single photon emission computed tomography (SPECT) images based on the microsphere model (SIMS method). Theoretically, the SIMS method could be changed to the simple non-invasive ARG (SIARG) method by modifying the integrated washout ratio (WR) to one-point WR. If the regional cerebral blood flow (rCBF) values derived from the SIARG and ARG methods correlate well, the facilities employing the ARG method can easily switch to the SIARG method...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29333464/comparison-of-tof-pet-and-bremsstrahlung-spect-images-of-yttrium-90-a-monte-carlo-simulation-study
#19
Akihiko Takahashi, Kazuhiko Himuro, Shingo Baba, Yasuo Yamashita, Masayuki Sasaki
Objectives: Yttrium-90 (90Y) is a beta particle nuclide used in targeted radionuclide therapy which is available to both single-photon emission computed tomography (SPECT) and time-of-flight (TOF) positron emission tomography (PET) imaging. The purpose of this study was to assess the image quality of PET and Bremsstrahlung SPECT by simulating PET and SPECT images of 90Y using Monte Carlo simulation codes under the same conditions and to compare them. Methods: In-house Monte Carlo codes, MCEP-PET and MCEP-SPECT, were employed to simulate images...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29331846/functional-neuroimaging-in-rasmussen-syndrome
#20
Ichiro Kuki, Kazumi Matsuda, Yuko Kubota, Tetsuhiro Fukuyama, Yukitoshi Takahashi, Yushi Inoue, Haruo Shintaku
PURPOSE: For a diagnosis of Rasmussen syndrome (RS), clinical course together with electroencephalography (EEG) and magnetic resonance imaging (MRI) findings are considered important, but there are few reports on functional neuroimaging. This study investigated cerebral blood flow (CBF)-single photon emission computed tomography (SPECT), central benzodiazepine receptor (BZR)-SPECT, and fluorine-18 fluorodeoxy glucose-positron emission tomography (FDG-PET) in RS patients, and correlated neuroimaging results with MRI and pathological findings...
January 5, 2018: Epilepsy Research
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