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https://www.readbyqxmd.com/read/28105807/laboratory-setup-for-scanning-free-grazing-emission-x-ray-fluorescence
#1
J Baumann, C Herzog, M Spanier, D Grötzsch, L Lühl, K Witte, A Jonas, S Günther, F Förste, R Hartmann, M Huth, D Kalok, D Steigenhöfer, M Krämer, T Holz, R Dietsch, L Strüder, B Kanngießer, I Mantouvalou
Grazing incidence and grazing emission X-ray fluorescence spectroscopy (GI/GE-XRF) are techniques that enable nondestructive, quantitative analysis of elemental depth profiles with a resolution in the nanometer regime. A laboratory setup for soft X-ray GEXRF measurements is presented. Reasonable measurement times could be achieved by combining a highly brilliant laser produced plasma (LPP) source with a scanning-free GEXRF setup, providing a large solid angle of detection. The detector, a pnCCD, was operated in a single photon counting mode in order to utilize its energy dispersive properties...
January 10, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28104744/spect-ct-imaging-of-the-novel-her2-targeted-peptide-probe-99mtc-hynic-h6f-in-breast-cancer-mouse-models
#2
Liqiang Li, Yue Wu, Zihua Wang, Bing Jia, Zhiyuan Hu, Chengyan Dong, Fan Wang
OBJECTIVES: Overexpression of human epidermal growth factor receptor 2 (HER2) plays important roles in tumorigenesis and tumor progression in breast cancer. Nuclear imaging of HER2 expression in tumors might detect all HER2-positive tumors throughout the body and guide HER2-targeted therapies for patients. We therefore aimed to develop a HER2-targeted peptide probe for breast cancer imaging. A novel single-photon emission computed tomography (SPECT) imaging probe, (99m)Tc-HYNIC-H6F, was prepared and then evaluated in breast cancer animal models...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28103749/clinical-practice-with-anti-dementia-drugs-a-revised-third-consensus-statement-from-the-british-association-for-psychopharmacology
#3
John T O'Brien, Clive Holmes, Matthew Jones, Roy Jones, Gill Livingston, Ian McKeith, Peter Mittler, Peter Passmore, Craig Ritchie, Louise Robinson, Elizabeth L Sampson, John-Paul Taylor, Alan Thomas, Alistair Burns
The British Association for Psychopharmacology coordinated a meeting of experts to review and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs. As before, levels of evidence were rated using accepted standards which were then translated into grades of recommendation A-D, with A having the strongest evidence base (from randomised controlled trials) and D the weakest (case studies or expert opinion). Current clinical diagnostic criteria for dementia have sufficient accuracy to be applied in clinical practice (B) and both structural (computed tomography and magnetic resonance imaging) and functional (positron emission tomography and single photon emission computerised tomography) brain imaging can improve diagnostic accuracy in particular situations (B)...
December 1, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28102203/storing-single-photons-emitted-by-a-quantum-memory-on-a-highly-excited-rydberg-state
#4
Emanuele Distante, Pau Farrera, Auxiliadora Padrón-Brito, David Paredes-Barato, Georg Heinze, Hugues de Riedmatten
Strong interaction between two single photons is a long standing and important goal in quantum photonics. This would enable a new regime of nonlinear optics and unlock several applications in quantum information science, including photonic quantum gates and deterministic Bell-state measurements. In the context of quantum networks, it would be important to achieve interactions between single photons from independent photon pairs storable in quantum memories. So far, most experiments showing nonlinearities at the single-photon level have used weak classical input light...
January 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28102031/dual-nano-sized-contrast-agents-in-pet-mri-a-systematic-review
#5
REVIEW
Afsaneh Lahooti, Saeed Sarkar, Sophie Laurent, Saeed Shanehsazzadeh
Nowadays molecular imaging plays a vital role in achieving a successful targeted and personalized treatment. Hence, the approach of combining two or more medical imaging modalities was developed. The objective of this review is to systematically compare recent dual contrast agents in Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) and in some cases Single photon emission computed tomography (SPECT)/MRI in terms of some their characteristics, such as tumor uptake, and reticuloendothelial system uptake (especially liver) and their relaxivity rates for early detection of primary cancer tumor...
November 2016: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/28093855/typical-and-atypical-appearance-of-early-onset-alzheimer-s-disease-a-clinical-neuroimaging-and-neuropathological-study-symposium-fundamentals-learned-from-diversity-among-typical-and-atypical-appearances
#6
Shinobu Kawakatsu 川勝 忍, Ryota Kobayashi, Hiroshi Hayashi
The International Working Group (IWG) has classified Alzheimer's disease (AD) as two different types, the typical form and the atypical form, but clinicopathological studies of atypical AD are limited. Because atypical AD cases usually present with early-onset dementia, we investigated 12 patients with early-onset AD, including two patients with typical AD and 10 patients with atypical AD. Of these patients, six had the posterior variant, three had the frontal variant and one had the logopenic variant mixed with semantic dementia...
January 17, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28093563/asymptomatic-mild-hyperperfusion-for-the-prediction-of-clinical-outcome-in-postoperative-patients-after-subarachnoid-hemorrhage
#7
Manabu Nakagawa, Tatsushi Mutoh, Shunsuke Takenaka, Tomoko Mutoh, Tomoko Totsune, Yasuyuki Taki, Tatsuya Ishikawa
BACKGROUND Delayed cerebral ischemia (DCI) is one of the main causes of poor outcomes after subarachnoid hemorrhage (SAH). The early identification of DCI by noninvasive imaging modalities would provide valuable information of therapeutic intervention for improving the patient outcomes. We aimed to describe the clinical features of cerebral blood flow (CBF) data obtained from the single-photon emission computed tomography (SPECT) during the risk period for DCI after SAH. MATERIAL AND METHODS Clinical data from 94 SAH patients who underwent surgical clipping of anterior circulation aneurysms were reviewed retrospectively...
January 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28091969/quality-of-life-as-predictor-for-the-development-of-cardiac-ischemia-in-high-risk-asymptomatic-diabetic-patients
#8
Philip Haaf, Myriam Ritter, Leticia Grize, Matthias E Pfisterer, Michael J Zellweger
BACKGROUND: Ischemia induced by psychological stress and depression is a common phenomenon in stable coronary artery disease (CAD). We evaluated the quality of life (QoL) of diabetic patients screened for CAD and assessed the prognostic value of mental and physical QoL scores to predict the development of new cardiac ischemia. METHODS: Prospective multicentre outcome study. The study comprised 400 asymptomatic diabetic patients without history or symptoms of CAD...
January 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28090078/interfacing-broadband-photonic-qubits-to-on-chip-cavity-protected-rare-earth-ensembles
#9
Tian Zhong, Jonathan M Kindem, Jake Rochman, Andrei Faraon
Ensembles of solid-state optical emitters enable broadband quantum storage and transduction of photonic qubits, with applications in high-rate quantum networks for secure communications and interconnecting future quantum computers. To transfer quantum states using ensembles, rephasing techniques are used to mitigate fast decoherence resulting from inhomogeneous broadening, but these techniques generally limit the bandwidth, efficiency and active times of the quantum interface. Here, we use a dense ensemble of neodymium rare-earth ions strongly coupled to a nanophotonic resonator to demonstrate a significant cavity protection effect at the single-photon level-a technique to suppress ensemble decoherence due to inhomogeneous broadening...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28089587/development-of-111-in-labeled-exendin-9-39-derivatives-for-single-photon-emission-computed-tomography-imaging-of-insulinoma
#10
Hiroyuki Kimura, Hirokazu Matsuda, Yu Ogawa, Hiroyuki Fujimoto, Kentaro Toyoda, Naotaka Fujita, Kenji Arimitsu, Keita Hamamatsu, Yusuke Yagi, Masahiro Ono, Nobuya Inagaki, Hideo Saji
Insulinoma is a tumor derived from pancreatic β-cells, and the resulting hyperinsulinemia leads to characteristic hypoglycemia. Recent studies have reported the frequent overexpression of glucagon-like peptide-1 receptor (GLP-1R) in human insulinomas, suggesting that the binding of a radiolabeled compound to GLP-1R is useful for the imaging of such tumors. Exendin(9-39), a fragment peptide of exendin-3 and -4, binds GLP-1R with high affinity and acts as an antagonist. Accordingly, radiolabeled exendin(9-39) derivatives have also been investigated as insulinoma imaging probes that might be less likely to induce hypoglycemia...
January 3, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28088866/a-combined-experimental-and-computational-study-on-the-unimolecular-decomposition-of-jp-8-jet-fuel-surrogates-ii-n-dodecane-n-c12h26
#11
Long Zhao, Tao Yang, Ralf I Kaiser, Tyler Patrick Troy, Musahid Ahmed, Joao Marcelo Ribeiro, Daniel Belisario-Lara, Alexander Moiseevich Mebel
We investigated temperature-dependent products in the pyrolysis of helium-seeded n-dodecane, which represents a surrogate of the n-alkane fraction of Jet Propellant-8 (JP-8) aviation fuel. The experiments were performed in a high temperature chemical reactor over a temperature range of 1,200 K to 1,600 K at a pressure of 600 Torr, with in situ identification of the nascent products in a supersonic molecular beam using single photon vacuum ultraviolet (VUV) photoionization coupled with the analysis of the ions in a reflectron time-of-flight mass spectrometer (ReTOF)...
January 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28088860/a-combined-experimental-and-computational-study-on-the-unimolecular-decomposition-of-jp-8-jet-fuel-surrogates-i-n-decane-n-c10h22
#12
Long Zhao, Tao Yang, Ralf I Kaiser, Tyler Patrick Troy, Musahid Ahmed, Daniel Belisario-Lara, Joao Marcelo Ribeiro, Alexander Moiseevich Mebel
Exploiting a high temperature chemical reactor, we explored the pyrolysis of helium-seeded n-decane as a surrogate of the n-alkane fraction of Jet Propellant-8 (JP-8) over a temperature range of 1,100 K to 1,600 K at a pressure of 600 Torr. The nascent products were identified in situ in a supersonic molecular beam via single photon vacuum ultraviolet (VUV) photoionization coupled with a mass spectroscopic analysis of the ions in a reflectron time-of-flight mass spectrometer (ReTOF). Our studies probe, for the first time, the initial reaction products formed in the decomposition of n-decane - including radicals and thermally labile closed-shell species effectively excluding mass growth processes...
January 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28086986/radioiodine-sinus-uptake-related-to-mucosal-thickening-or-aspergilloma-a-case-series-of-an-unrecognized-event-well-evidenced-by-spect-ct
#13
Renaud Ciappuccini, David Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Emmanuel Babin, Stéphane Bardet
BACKGROUND: False-positive radioiodine (RAI) uptake related to chronic sinusitis and mucocele has only rarely been reported in patients with differentiated thyroid cancer (DTC) even with the recent use of single photon emission tomography with computed tomography (SPECT/CT) acquisition. No other etiology of sinus RAI uptake has been mentioned to date. OBJECTIVES: We report five cases of DTC patients with sinus RAI uptake on post-RAI scintigraphy. SPECT/CT clearly localized RAI uptake either in the sphenoid, the maxillary or the frontal sinus and highly suspected mucosal thickening in four patients and sinus aspergilloma in one patient...
January 13, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28079797/case-report-rapid-improvement-of-crossed-cerebellar-diaschisis-after-intravascular-laser-irradiation-of-blood-in-a-case-of-stroke
#14
Wan-Hua Yang, Shiou-Ping Lin, Shin-Tsu Chang
RATIONALE: Crossed cerebellar diaschisis (CCD) is a poor prognostic factor after stroke because without immediate cerebral reperfusion no further improvements in the patient's condition can be achieved. We investigated the clinical effects of intravascular laser irradiation therapy (ILIB) on CCD and evaluated the therapeutic effect in the sub-acute post-stroke stage. PATIENT CONCERNS: The 77-year-old male with cerebral infarction in the territory of the right anterior cerebral artery only underwent conservative treatment including hydration and aspirin in the acute post-stroke stage...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079701/ex-vivo-assessment-of-coronary-atherosclerotic-plaque-by-grating-based-phase-contrast-computed-tomography-correlation-with-optical-coherence-tomography
#15
Christopher Habbel, Holger Hetterich, Marian Willner, Julia Herzen, Kristin Steigerwald, Sigrid Auweter, Ulrich Schüller, Jörg Hausleiter, Steffen Massberg, Maximilian Reiser, Franz Pfeiffer, Tobias Saam, Fabian Bamberg
OBJECTIVES: The aim of this study was to determine the diagnostic accuracy of grating-based phase-contrast computed tomography (gb-PCCT) to classify and quantify coronary vessel characteristics in comparison with optical coherence tomography (OCT) and histopathology in an ex vivo setting. MATERIALS AND METHODS: After excision from 5 heart specimens, 15 human coronary arteries underwent gb-PCCT examination using an experimental imaging setup consisting of a rotating molybdenum anode x-ray tube, a Talbot-Lau grating interferometer, and a single photon counting detector...
January 10, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28076008/pictorial-review-of-false-positive-results-on-radioiodine-scintigrams-of-patients-with-differentiated-thyroid-cancer
#16
Amy V Chudgar, Jagruti C Shah
Radioiodine has served an important role in the diagnostic workup and treatment of patients with differentiated thyroid cancer for more than 6 decades. The interpretation of radioiodine scintigraphic studies should be performed in conjunction with a comprehensive history, histopathologic correlation, and pertinent laboratory values, as well as correlation with available anatomic images and the findings from physical examination. A thorough understanding of the physiology and biodistribution of radioiodine is critical when interpreting radioiodine scintigraphic studies to avoid misinterpretation of physiologic and nonthyroid pathologic variants as thyroid cancer metastases...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28074781/mechanically-tunable-sub-10-nm-metal-gap-by-stretching-pdms-substrate
#17
Wenjie Liu, Yang Shen, Guohui Xiao, Xiaoyi She, Jianfang Wang, Chongjun Jin
Manipulating light in sub-10 nm or subnanometer metal nanogaps is crucial to study the strong interaction between electromagnetic waves and matters. However, the fabrication of metallic nanogaps with precisely controlled size and high-throughput still remains a challenge. Here, we developed an approach to actively control the gap distance between adjacent metal nanoparticles from 140 nm to sub-10 nm or even 0 nm via mechanical stretching process. To demonstrate this method, we manufactured the gold disk arrays in a square lattice on the polydimethylsiloxane (PDMS) substrate through interference lithography and gold deposition, and sub-10 nm interparticle gap was achieved as exerting a strain of 100% to the PDMS substrate...
January 11, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28070037/-bm-mscs-from-wuzhishan-mini-pigs-delay-the-progress-of-renal-fibrosis-induced-by-chronic-kidney-disease-through-%C3%A2-autocrine-hepatocyte-growth-factor-in-vitro
#18
Yang Xiang, Jiale Long, Jiansheng Xing, Yuanhui Gao, Qing Cheng, Yong Cai, Zhenxiang Liu, Shufang Zhang, Lie Chen, Chao Yang, Zhiming Bai
To isolate bone marrow mesenchymal stem cells (BM-MSCs) and establish the model of chronic kidney disease (CKD) of Wuzhishan (WZS) mini-pig, and to study the repairment effect of BM-MSCs on CKD-induced renal fibrosis in vitro.
 Methods: Density gradient method was used to isolate and culture BM-MSCs. The cells were verified by morphology, phenotype, differentiation and so on. The left partial ureteral obstruction (LPUUO) was used to establish the CKD model, which was evaluated by B-ultrasound, single-photon emission computed tomography (SPECT), HE and Masson staining...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28069773/orbital-angular-momentum-of-photons-and-the-entanglement-of-laguerre-gaussian-modes
#19
REVIEW
Mario Krenn, Mehul Malik, Manuel Erhard, Anton Zeilinger
The identification of orbital angular momentum (OAM) as a fundamental property of a beam of light nearly 25 years ago has led to an extensive body of research around this topic. The possibility that single photons can carry OAM has made this degree of freedom an ideal candidate for the investigation of complex quantum phenomena and their applications. Research in this direction has ranged from experiments on complex forms of quantum entanglement to the interaction between light and quantum states of matter...
February 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28067149/navigation-assisted-trans-inferotemporal-cortex-selective-amygdalohippocampectomy-for-mesial-temporal-lobe-epilepsy-preserving-the-temporal-stem
#20
Haruhiko Kishima, Amami Kato, Satoru Oshino, Naoki Tani, Tomoyuki Maruo, Hui Ming Khoo, Takufumi Yanagisawa, Kotaro Edakawa, Maki Kobayashi, Masataka Tanaka, Koichi Hosomi, Masayuki Hirata, Toshiki Yoshimine
OBJECTIVE: Selective amygdalohippocampectomy (SAH) can be used to obtain satisfactory seizure control in patients with mesial temporal lobe epilepsy (MTLE). Several SAH procedures have been reported to achieve satisfactory outcomes for seizure control, but none yield fully satisfactory outcomes for memory function. We hypothesized that preserving the temporal stem might play an important role. To preserve the temporal stem, we developed a minimally invasive surgical procedure, 'neuronavigation-assisted trans-inferotemporal cortex SAH' (TITC-SAH)...
January 9, 2017: Neurological Research
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