Viky Y Suncion, Eduard Ghersin, Joel E Fishman, Juan Pablo Zambrano, Vasileios Karantalis, Nicole Mandel, Katarina H Nelson, Gary Gerstenblith, Darcy L DiFede Velazquez, Elayne Breton, Kranthi Sitammagari, Ivonne H Schulman, Sabrina N Taldone, Adam R Williams, Cristina Sanina, Peter V Johnston, Jeffrey Brinker, Peter Altman, Muzammil Mushtaq, Barry Trachtenberg, Adam M Mendizabal, Melissa Tracy, Jose Da Silva, Ian K McNiece, Alberto C Lardo, Richard T George, Joshua M Hare, Alan W Heldman
RATIONALE: Transendocardial stem cell injection (TESI) with mesenchymal stem cells improves remodeling in chronic ischemic cardiomyopathy, but the effect of the injection site remains unknown. OBJECTIVE: To address whether TESI exerts its effects at the site of injection only or also in remote areas, we hypothesized that segmental myocardial scar and segmental ejection fraction improve to a greater extent in injected than in noninjected segments. METHODS AND RESULTS: Biplane ventriculographic and endocardial tracings were recorded...
April 11, 2014: Circulation Research