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Ventricular myocardial band

Patricia Reant, Alexandre Metras, Dominique Detaille, Annabel Reynaud, Philippe Diolez, Beatrice Jaspard-Vinassa, Raymond Roudaut, Alexandre Ouattara, Laurent Barandon, Pierre Dos Santos, Stephane Lafitte
BACKGROUND: Left ventricular (LV) afterload could be associated with reduced myocardial contractility. The aim of this study was to evaluate the relative impact of increased afterload on LV myocardial deformation indices in chronic aortic constriction, with regard to hypertrophy, myocardial fibrosis, and mitochondrial function, and to differentiate acute versus chronic afterload effect. METHODS: Young pigs underwent aortic banding (n = 11) or sham (n = 7) operations...
October 14, 2016: Journal of the American Society of Echocardiography
Julius Bogomolovas, Jennifer R Fleming, Brian R Anderson, Rhys Williams, Stephan Lange, Bernd Simon, Muzamil M Khan, Rüdiger Rudolf, Barbara Franke, Belinda Bullard, Daniel J Rigden, Henk Granzier, Siegfried Labeit, Olga Mayans
Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of heart failure. However, distinguishing between benign and disease-causing mSNPs is a substantial challenge. Here, we research the question of whether a single mSNP in a generic domain of titin can affect heart function as a whole and, if so, how. For this, we studied the mSNP T2850I, seemingly linked to arrhythmogenic right ventricular cardiomyopathy (ARVC). We used structural biology, computational simulations and transgenic muscle in vivo methods to track the effect of the mutation from the molecular to the organismal level...
September 2016: Open Biology
Xiaoying Ying, Yichao Zhao, Tianbao Yao, Ancai Yuan, Longwei Xu, Lingchen Gao, Song Ding, Hongyi Ding, Jun Pu, Ben He
Ubiquitin-specific protease 18 (USP18), a USP family member, is involved in antiviral activity and cancer inhibition. Although USP18 is expressed in heart, the role of USP18 in the heart and in cardiac diseases remains unknown. Here, we show that USP18 expression is elevated in both human dilated hearts and hypertrophic murine models. Cardiomyocyte-specific overexpression of USP18 in mice significantly blunted cardiac remodeling as evidenced by mitigated myocardial hypertrophy, fibrosis, ventricular dilation, and preserved ejection function, whereas USP18-deficient mice displayed exacerbated cardiac remodeling under the same pathological stimuli...
November 2016: Hypertension
Jiri Kobr, Zdenek Slavik, Hideki Uemura, Imran Saeed, Anke Furck, Katerina Pizingerová, Jiri Fremuth, Zbynek Tonar
The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular haemodynamic parameters and myocardial changes in biomodel of right ventricular hypertension. The study included a total of 12 piglets of 42 days of age. Under general anaesthesia, pulmonary artery banding (PAB) was performed surgically to constrict the main pulmonary artery to about 70-80 % of its original dimension...
August 24, 2016: Pediatric Cardiology
Narges L Horriat, Sara L Deatsman, Jessica Stelter, Peter C Frommelt, Garick D Hill
Initial surgical strategies in neonates with single left ventricular (LV) anatomy vary based on adequacy of pulmonary and systemic blood flow. Differing myocardial responses to these strategies, as reflected in indices of systolic function, ventricular size, and mass have not been well defined. We sought to evaluate single LV myocardial response to varied physiology and initial palliation and determine whether the response is consistent and predictable. Infants with single LV physiology were divided based on neonatal palliation: no palliation/PA band (NO); BT shunt only (BT); or Norwood procedure (NP)...
August 23, 2016: Pediatric Cardiology
Mathew Bull, Mei Methawasin, Joshua Strom, Pooja Nair, Kirk Hutchinson, Henk Granzier
RATIONALE: Patients with heart failure with preserved ejection fraction (HFpEF) experience elevated filling pressures and reduced ventricular compliance. The splicing factor RNA-binding motif 20 (RBM20) regulates the contour length of titin's spring region and thereby determines the passive stiffness of cardiomyocytes. Inhibition of RBM20 leads to super compliant titin isoforms (N2BAsc) that reduce passive stiffness. OBJECTIVE: To determine the therapeutic potential of upregulating compliant titin isoforms in an HFpEF-like state in the mouse...
September 2, 2016: Circulation Research
Petr A Sarapultsev, Alexey P Sarapultsev
In 2006, Takotsubo syndrome (TTC) was described as a distinct type of stress-induced cardiomyopathy (stress cardiomyopathy). However, when thinking about Takotsubo cardiomyopathy from the viewpoints of the AHA and ESC classifications, 2 possible problems may arise. The first potential problem is that a forecast of disease outcome is lacking in the ESC classification, whereas the AHA only states that 'outcome is favorable with appropriate medical therapy'. However, based on the literature data, one can make a general conclusion that occurrence of myocardial lesions in TTC (i...
October 15, 2016: International Journal of Cardiology
Raquel García, David Merino, Jenny M Gómez, J Francisco Nistal, María A Hurlé, Aitziber L Cortajarena, Ana V Villar
The pathological remodeling heart shows an increase in left ventricular mass and an excess of extracellular matrix deposition that can over time cause heart failure. Transforming growth factor β (TGFβ) is the main cytokine controlling this process. The molecular chaperone heat shock protein 90 (Hsp90) has been shown to play a critical role in TGFβ signaling by stabilizing the TGFβ signaling cascade. We detected extracellular Hsp90 in complex with TGFβ receptor I (TGFβRI) in fibroblasts and determined a close proximity between both proteins suggesting a potential physical interaction between the two at the plasma membrane...
October 2016: Cellular Signalling
Silvia Rain, Stine Andersen, Aref Najafi, Jacob Gammelgaard Schultz, Denielli da Silva Gonçalves Bós, M Louis Handoko, Harm-Jan Bogaard, Anton Vonk-Noordegraaf, Asger Andersen, Jolanda van der Velden, Coen A C Ottenheijm, Frances S de Man
BACKGROUND: The purpose of this study was to determine the relative contribution of fibrosis-mediated and myofibril-mediated stiffness in rats with mild and severe right ventricular (RV) dysfunction. METHODS AND RESULTS: By performing pulmonary artery banding of different diameters for 7 weeks, mild RV dysfunction (Ø=0.6 mm) and severe RV dysfunction (Ø=0.5 mm) were induced in rats. The relative contribution of fibrosis- and myofibril-mediated RV stiffness was determined in RV trabecular strips...
July 2016: Circulation. Heart Failure
Mihály Ruppert, Sevil Korkmaz-Icöz, Shiliang Li, Balázs Tamás Németh, Péter Hegedűs, Paige Brlecic, Csaba Mátyás, Markus Zorn, Béla Merkely, Matthias Karck, Tamás Radovits, Gábor Szabó
Pressure unloading represents the only effective therapy in increased afterload-induced left ventricular hypertrophy (LVH) as it leads to myocardial reverse remodeling (reduction of increased left ventricular mass, attenuated myocardial fibrosis) and preserved cardiac function. However, the effect of myocardial reverse remodeling on cardiac mechanoenergetics has not been elucidated. Therefore, we aimed to provide a detailed hemodynamic characterization in a rat model of LVH undergoing pressure unloading. Pressure overload was induced in Sprague-Dawley rats by abdominal aortic banding for 6 (AB 6th wk) or 12 wk (AB 12th wk)...
September 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Fumiaki Kimura, Sentarou Nakanishi, Hiroyuki Kamiya
A 61-year-old man presented with lower leg edema, left-sided parasternal systolic heart murmur, and electrocardiographic abnormalities. Transthoracic echocardiography revealed myocardial hypertrophy and severe obstruction of the outflow tract of the right ventricle (RV) with a gradient of 134 mmHg. Cardiac catheterization confirmed the presence of double chambered right ventricle, with a pressure gradient of 84 mmHg between RV inlet and outlet. Chest computed tomography showed his aortic root enlarged to 55 mm...
May 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Yan-chang Ge, Li-na Huang, Kai-jun Ma
OBJECTIVE: To investigate the pathological features and significance of myocardial contraction band necrosis in sudden cardiac death. METHODS: Using HE and PTAH staining, the distribution sites and pathological features of myocardial contraction band necrosis were observed. The data were analyzed according to the extent of necrosis. RESULTS: The locations, pathological features and the extent of necrosis were similar in different sudden death cases...
December 2015: Fa Yi Xue za Zhi
Brody Wehman, Sudhish Sharma, Nicholas Pietris, Rachana Mishra, Osama T Siddiqui, Grace Bigham, Tieluo Li, Emily Aiello, Sarah Murthi, Mark Pittenger, Bartley Griffith, Sunjay Kaushal
Limited therapies exist for patients with congenital heart disease (CHD) who develop right ventricular (RV) dysfunction. Bone marrow-derived mesenchymal stem cells (MSCs) have not been evaluated in a preclinical model of pressure overload, which simulates the pathophysiology relevant to many forms of CHD. A neonatal swine model of RV pressure overload was utilized to test the hypothesis that MSCs preserve RV function and attenuate ventricular remodeling. Immunosuppressed Yorkshire swine underwent pulmonary artery banding to induce RV dysfunction...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Venkat Keshav Chivukula, Sevan Goenezen, Aiping Liu, Sandra Rugonyi
We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion in the OFT are affected by banding in ways that might not be intuitive a priori...
March 2016: Journal of Cardiovascular Development and Disease
Luciana Midaglia, Jesús M Juega Mariño, Jaume Sastre-Garriga, Alex Rovira, Angela Vidal-Jordana, María A López-Pérez, María E Marzo-Sola, Fausto Librada Escribano, Xavier Montalban
BACKGROUND: Clinically isolated syndromes affecting the brainstem may present with rare manifestations such as neurogenic pulmonary oedema (NPO). OBJECTIVES: We present the case of a 23 year-old man with NPO caused by Tako-Tsubo cardiomyopathy (TTC) as a first manifestation of multiple sclerosis (MS). METHODS AND RESULTS: A brain magnetic resonance imaging scan at admission showed multiple supra and infratentorial white matter inflammatory demyelinating lesions...
May 2016: Multiple Sclerosis: Clinical and Laboratory Research
Masaya Sugimoto, Hirofumi Saiki, Akiko Tamai, Mitsuru Seki, Ryo Inuzuka, Satoshi Masutani, Hideaki Senzaki
OBJECTIVE: We tested the hypotheses that volume overload and cyanosis observed in the pre-Fontan single ventricular circulation are associated with increased ventricular fibrogenesis, that the Fontan procedure helps to reduce fibrogenesis, and that persistently increased fibrogenesis in the Fontan ventricle is associated with ventricular diastolic dysfunction. METHODS: Levels of serum amino-terminal procollagen type III, a marker of tissue fibrogenesis, were measured in 172 patients with single ventricle circulation and 149 controls...
June 2016: Journal of Thoracic and Cardiovascular Surgery
Stephan C A Wens, Gerben J Schaaf, Michelle Michels, Michelle E Kruijshaar, Tom J M van Gestel, Stijn In 't Groen, Joon Pijnenburg, Dick H W Dekkers, Jeroen A A Demmers, Lex B Verdijk, Esther Brusse, Ron H N van Schaik, Ans T van der Ploeg, Pieter A van Doorn, W W M Pim Pijnappel
BACKGROUND: Elevated plasma cardiac troponin T (cTnT) levels in patients with neuromuscular disorders may erroneously lead to the diagnosis of acute myocardial infarction or myocardial injury. METHODS AND RESULTS: In 122 patients with Pompe disease, the relationship between cTnT, cardiac troponin I, creatine kinase (CK), CK-myocardial band levels, and skeletal muscle damage was assessed. ECG and echocardiography were used to evaluate possible cardiac disease. Patients were divided into classic infantile, childhood-onset, and adult-onset patients...
February 2016: Circulation. Cardiovascular Genetics
L B Christiansen, C Prats, P Hyttel, J Koch
OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats and shares clinical and pathological characteristics with human HCM. Little is known about the pathogenic mechanisms underlying development of spontaneous feline HCM. ANIMALS: The study population consisted of seven cats diagnosed with HCM and eight age-matched cats with no evidence of cardiac disease. METHODS: Fresh myocardial biopsies taken from the middle of the left ventricular posterior free wall were obtained and examined with transmission electron microscopy...
December 2015: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Attila Oláh, Balázs Tamás Németh, Csaba Mátyás, László Hidi, Árpád Lux, Mihály Ruppert, Dalma Kellermayer, Alex Ali Sayour, Lilla Szabó, Marianna Török, Anna Meltzer, László Gellér, Béla Merkely, Tamás Radovits
Left ventricular (LV) hypertrophy is a physiological or pathological response of LV myocardium to increased cardiac load. We aimed at investigating and comparing hemodynamic alterations in well-established rat models of physiological hypertrophy (PhyH) and pathological hypertrophy (PaH) by using LV pressure-volume (P-V) analysis. PhyH and PaH were induced in rats by swim training and by abdominal aortic banding, respectively. Morphology of the heart was investigated by echocardiography. Characterization of cardiac function was completed by LV P-V analysis...
March 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Jesús Vargas-Barron, Omar-Yassef Antunez-Montes, Francisco-Javier Roldán, Alberto Aranda-Frausto, Hector González-Pacheco, Ángel Romero-Cardenas, Miguel Zabalgoitia
BACKGROUND: Torrent-Guasp explains the structure of the ventricular myocardium by means of a helical muscular band. Our primary purpose was to demonstrate the utility of echocardiography in human and porcine hearts in identifying the segments of the myocardial band. The second purpose was to evaluate the relation of the topographic distribution of the myocardial band with some post-myocardial infarction ruptures. METHODS: Five porcine and one human heart without cardiopathy were dissected and the ventricular myocardial segments were color-coded for illustration and reconstruction purposes...
September 2015: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
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