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https://www.readbyqxmd.com/read/28409155/preservation-of-myocardial-perfusion-and-function-by-keeping-hypertrophied-heart-empty-and-beating-for-valve-surgery-an-in-vivo-mr-study-of-pig-hearts
#1
Jian Wang, Bo Xiang, Jixian Deng, Hung-Yu Lin, Darren H Freed, Rakesh C Arora, Ganghong Tian
Objectives. Normothermic hyperkalemic cardioplegia arrest (NHCA) may not effectively preserve hypertrophied myocardium during open-heart surgery. Normothermic normokalemic beating perfusion (NNBP), keeping hearts empty-beating, was utilized as an alternative to evaluate its cardioprotective role. Materials and Methods. Twelve hypertrophied pig hearts at 58.6 ± 7.2 days after ascending aorta banding underwent NNBP and NHCA, respectively. Near infrared myocardial perfusion imaging with indocyanine green (ICG) was conducted to assess myocardial perfusion...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28360193/a-role-for-galectin-3-in-the-development-of-early-molecular-alterations-in-short-term-aortic-stenosis
#2
Vanessa Arrieta, Ernesto Martínez-Martínez, Jaime Ibarrola, Virginia Alvarez, Rafael Justo Sádaba, Amaia García-Peña, Amaya Fernández-Celis, Victoria Cachofeiro, Patrick Rossignol, Natalia Lopez-Andres
Aortic stenosis (AS) is characterized by pressure overload and causes left ventricular (LV) fibrosis and inflammation, two mechanisms which finally lead to cardiac dysfunction. Galectin-3 (Gal-3), a β-galactoside-binding lectin, promotes cardiac remodeling. We herein investigated the role of Gal-3 in LV remodeling in patients with AS and the effects of Gal-3 blockade in rats subjected to short-term (6-week) supravalvular aortic banding (AS group). Myocardial biopsies were obtained from 25 patients with severe AS referred for aortic valve replacement and from necropsies of 11 cardiovascular disease-free control subjects...
March 30, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28330950/pressure-overload-leads-to-an-increased-accumulation-and-activity-of-mast-cells-in-the-right-ventricle
#3
Himal Luitel, Akylbek Sydykov, Yves Schymura, Argen Mamazhakypov, Wiebke Janssen, Kabita Pradhan, Astrid Wietelmann, Djuro Kosanovic, Bhola Kumar Dahal, Norbert Weissmann, Werner Seeger, Friedrich Grimminger, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly
Right ventricular (RV) remodeling represents a complex set of functional and structural adaptations in response to chronic pressure or volume overload due to various inborn defects or acquired diseases and is an important determinant of patient outcome. However, the underlying molecular mechanisms remain elusive. We investigated the time course of structural and functional changes in the RV in the murine model of pressure overload-induced RV hypertrophy in C57Bl/6J mice. Using magnetic resonance imaging, we assessed the changes of RV structure and function at different time points for a period of 21 days...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28321573/a-longer-total-duration-of-rapid-ventricular-pacing-does-not-increase-the-risk-of-postprocedural-myocardial-injury-in-patients-who-undergo-transcatheter-aortic-valve-implantation
#4
Kenta Okitsu, Takeshi Iritakenishi, Tatsuyuki Imada, Mitsuo Iwasaki, Sho Carl Shibata, Yuji Fujino
Rapid ventricular pacing (RVP) is used during transcatheter aortic valve implantation (TAVI). RVP disturbs myocardial oxygen balance, and when prolonged, it may cause procedure-related myocardial injury (PMI). This study investigated whether a longer duration of RVP increased the occurrence of PMI or worsened long-term mortality after TAVI. We retrospectively analyzed data from 188 patients who underwent TAVI in our institute from January 2013 to July 2015. Myocardial injury was represented by the peak value of creatine kinase-myocardial band (CK-MB) within 72 h after the procedure; an increase greater than 5 times the upper reference limit was regarded as PMI...
March 20, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28245984/conformational-and-thermal-characterization-of-left-ventricle-remodeling-post-myocardial-infarction
#5
V Samouillan, E Revuelta-López, C Soler-Botija, J Dandurand, Aleyda Benitez-Amaro, L Nasarre, D de Gonzalo-Calvo, A Bayes-Genis, C Lacabanne, V Llorente-Cortés
Adverse cardiac remodeling after myocardial infarction (MI) causes impaired ventricular function and heart failure. Histopathological characterization is commonly used to detect the location, size and shape of MI sites. However, the information about chemical composition, physical structure and molecular mobility of peri- and infarct zones post-MI is rather limited. The main objective of this work was to explore the spatiotemporal biochemical and biophysical alterations of key cardiac components post-MI. The FTIR spectra of healthy and remote myocardial tissue shows amides A, I, II and III associated with proteins in freeze-died tissue as major absorptions bands...
February 25, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28159427/left-ventricular-rigid-body-rotation-in-a-diffuse-large-b-cell-lymphoma-patient-with-cardiac-involvement-a-case-from-the-three-dimensional-speckle-tracking-echocardiographic-magyar-path-study
#6
Dóra Földeák, Anita Kalapos, Péter Domsik, Mária Sinkó, Nóra Szeleczki, Enikő Bagdi, László Krenács, Tamás Forster, Zita Borbényi, Attila Nemes
Secondary myocardial involvement by diffuse large B-cell lymphoma is a rare occurrence. Left ventricular (LV) twist is considered an essential part of LV function. In normal circumstances LV twist results from the movement of two orthogonally oriented muscular bands of a helical myocardial structure with consequent clockwise rotation of the base and counterclockwise rotation of the apex. Three-dimensional (3D) speckle-tracking echocardiography (3DSTE) has been found to be feasible for non-invasive 3D quantification of LV wall motion and rotational mechanics...
February 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28123181/reverse-electrical-remodeling-following-pressure-unloading-in-a-rat-model-of-hypertension-induced-left-ventricular-myocardial-hypertrophy
#7
Mihály Ruppert, Sevil Korkmaz-Icöz, Shiliang Li, Béla Merkely, Matthias Karck, Tamás Radovits, Gábor Szabó
Pressure overload-induced left ventricular myocardial hypertrophy (LVH) is characterized by increased proarrhythmic vulnerability. In contrast, pressure unloading leads to reverse remodeling and decreases LVH-associated arrhythmogenicity. However, cellular changes that occur during reverse electrical remodeling have been studied less. Therefore, we aimed to provide an electrocardiographic characterization of a rat model of LVH that underwent pressure unloading and to simultaneously identify the underlying cellular and functional alterations...
January 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28068381/impairment-of-excitation-contraction-coupling-in-right-ventricular-hypertrophied-muscle-with-fibrosis-induced-by-pulmonary-artery-banding
#8
Yoichiro Kusakari, Takashi Urashima, Daisuke Shimura, Erika Amemiya, Genki Miyasaka, Shunsuke Yokota, Yoshitaka Fujimoto, Toru Akaike, Takahiro Inoue, Susumu Minamisawa
Interstitial myocardial fibrosis is one of the factors responsible for dysfunction of the heart. However, how interstitial fibrosis affects cardiac function and excitation-contraction coupling (E-C coupling) has not yet been clarified. We developed an animal model of right ventricular (RV) hypertrophy with fibrosis by pulmonary artery (PA) banding in rats. Two, four, and six weeks after the PA-banding operation, the tension and intracellular Ca2+ concentration of RV papillary muscles were simultaneously measured (n = 33)...
2017: PloS One
https://www.readbyqxmd.com/read/27879192/n-terminal-probrain-natriuretic-peptide-in-patients-with-acute-coronary-syndrome%C3%A2
#9
Qi Kang, Zheng Wan, Zhenwen Huang
OBJECTIVE: To observe the changes and evaluate the significance of serum N-terminal probrain natriuretic peptide (NT-proBNP) levels in patients with acute coronary syndrome and to discuss its clinical significance and relationship with the severity of disease. METHODS: Serum NT-proBNP levels were determined rapidly by using the triage BNP test for 98 consecutive patients with coronary heart disease (CAD) admitted to the hospital from March 2013 to December 2013; the correlation between the concentration of NT-proBNP and the degree of severity of the disease was analyzed...
January 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27875730/contemporary-review-on-the-pathogenesis-of-takotsubo-syndrome-the-heart-shedding-tears-norepinephrine-churn-and-foam-at-the-cardiac-sympathetic-nerve-terminals
#10
REVIEW
Shams Y-Hassan, Rodney De Palma
Takotsubo syndrome (TS), an increasingly recognized acute cardiac disease entity, is characterized by a unique pattern of circumferential and typically regional left ventricular wall motion abnormality resulting in a conspicuous transient ballooning of the left ventricle during systole. The mechanism of the disease remains elusive. However, the sudden onset of acute myocardial stunning in a systematic pattern extending beyond a coronary artery territory; the history of a preceding emotional or physical stress factor in two thirds of cases; the signs of sympathetic denervation at the regions of left ventricular dysfunction on sympathetic scintigraphy; the finding of myocardial edema and other signs consistent with (catecholamine-induced) myocarditis shown by cardiac magnetic resonance imaging; and the contraction band necrosis on histopathological examination all argue strongly for the involvement of the cardiac sympathetic nervous system in the pathogenesis of TS...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27853261/cinaciguat-prevents-the-development-of-pathologic-hypertrophy-in-a-rat-model-of-left-ventricular-pressure-overload
#11
Balázs Tamás Németh, Csaba Mátyás, Attila Oláh, Árpád Lux, László Hidi, Mihály Ruppert, Dalma Kellermayer, Gábor Kökény, Gábor Szabó, Béla Merkely, Tamás Radovits
Pathologic myocardial hypertrophy develops when the heart is chronically pressure-overloaded. Elevated intracellular cGMP-levels have been reported to prevent the development of pathologic myocardial hypertrophy, therefore we investigated the effects of chronic activation of the cGMP producing enzyme, soluble guanylate cyclase by Cinaciguat in a rat model of pressure overload-induced cardiac hypertrophy. Abdominal aortic banding (AAB) was used to evoke pressure overload-induced cardiac hypertrophy in male Wistar rats...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27783876/insights-from-echocardiography-magnetic-resonance-imaging-and-microcomputed-tomography-relative-to-the-mid-myocardial-left-ventricular-echogenic-zone
#12
Peter Agger, Robert S Stephenson, Halina Dobrzynski, Andrew Atkinson, Paul A Iaizzo, Robert H Anderson, Jonathan C Jarvis, Sarah L Allan, John B Partridge, Jichao Zhao, Henggui Zhang, David H MacIver
BACKGROUND: The anatomical substrate for the mid-mural ventricular hyperechogenic zone remains uncertain, but it may represent no more than ultrasound reflected from cardiomyocytes orientated orthogonally to the ultrasonic beam. We sought to ascertain the relationship between the echogenic zone and the orientation of the cardiomyocytes. METHODS: We used 3D echocardiography, diffusion tensor imaging, and microcomputed tomography to analyze the location and orientation of cardiomyocytes within the echogenic zone...
October 2016: Echocardiography
https://www.readbyqxmd.com/read/27783872/the-helical-ventricular-myocardial-band-or-what-s-in-a-name
#13
EDITORIAL
Julien I E Hoffman
No abstract text is available yet for this article.
October 2016: Echocardiography
https://www.readbyqxmd.com/read/27751650/impact-of-afterload-increase-on-left-ventricular-myocardial-deformation-indices
#14
Patricia Reant, Alexandre Metras, Dominique Detaille, Annabel Reynaud, Philippe Diolez, Beatrice Jaspard-Vinassa, Raymond Roudaut, Alexandre Ouattara, Laurent Barandon, Pierre Dos Santos, Stephane Lafitte
BACKGROUND: Left ventricular (LV) afterload could be associated with reduced myocardial contractility. The aim of this study was to evaluate the relative impact of increased afterload on LV myocardial deformation indices in chronic aortic constriction, with regard to hypertrophy, myocardial fibrosis, and mitochondrial function, and to differentiate acute versus chronic afterload effect. METHODS: Young pigs underwent aortic banding (n = 11) or sham (n = 7) operations...
December 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27683155/exploration-of-pathomechanisms-triggered-by-a-single-nucleotide-polymorphism-in-titin-s-i-band-the-cardiomyopathy-linked-mutation-t2580i
#15
Julius Bogomolovas, Jennifer R Fleming, Brian R Anderson, Rhys Williams, Stephan Lange, Bernd Simon, Muzamil M Khan, Rüdiger Rudolf, Barbara Franke, Belinda Bullard, Daniel J Rigden, Henk Granzier, Siegfried Labeit, Olga Mayans
Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of heart failure. However, distinguishing between benign and disease-causing mSNPs is a substantial challenge. Here, we research the question of whether a single mSNP in a generic domain of titin can affect heart function as a whole and, if so, how. For this, we studied the mSNP T2850I, seemingly linked to arrhythmogenic right ventricular cardiomyopathy (ARVC). We used structural biology, computational simulations and transgenic muscle in vivo methods to track the effect of the mutation from the molecular to the organismal level...
September 2016: Open Biology
https://www.readbyqxmd.com/read/27572150/novel-protective-role-for-ubiquitin-specific-protease-18-in-pathological-cardiac-remodeling
#16
Xiaoying Ying, Yichao Zhao, Tianbao Yao, Ancai Yuan, Longwei Xu, Lingchen Gao, Song Ding, Hongyi Ding, Jun Pu, Ben He
Ubiquitin-specific protease 18 (USP18), a USP family member, is involved in antiviral activity and cancer inhibition. Although USP18 is expressed in heart, the role of USP18 in the heart and in cardiac diseases remains unknown. Here, we show that USP18 expression is elevated in both human dilated hearts and hypertrophic murine models. Cardiomyocyte-specific overexpression of USP18 in mice significantly blunted cardiac remodeling as evidenced by mitigated myocardial hypertrophy, fibrosis, ventricular dilation, and preserved ejection function, whereas USP18-deficient mice displayed exacerbated cardiac remodeling under the same pathological stimuli...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27558550/right-ventricular-pressure-overload-and-pathophysiology-of-growing-porcine-biomodel
#17
Jiri Kobr, Zdenek Slavik, Hideki Uemura, Imran Saeed, Anke Furck, Katerina Pizingerová, Jiri Fremuth, Zbynek Tonar
The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular haemodynamic parameters and myocardial changes in biomodel of right ventricular hypertension. The study included a total of 12 piglets of 42 days of age. Under general anaesthesia, pulmonary artery banding (PAB) was performed surgically to constrict the main pulmonary artery to about 70-80 % of its original dimension...
December 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27554256/variable-myocardial-response-to-load-stresses-in-infants-with-single-left-ventricular-anatomy-influence-of-initial-physiology-and-surgical-palliative-strategy
#18
Narges L Horriat, Sara L Deatsman, Jessica Stelter, Peter C Frommelt, Garick D Hill
Initial surgical strategies in neonates with single left ventricular (LV) anatomy vary based on adequacy of pulmonary and systemic blood flow. Differing myocardial responses to these strategies, as reflected in indices of systolic function, ventricular size, and mass have not been well defined. We sought to evaluate single LV myocardial response to varied physiology and initial palliation and determine whether the response is consistent and predictable. Infants with single LV physiology were divided based on neonatal palliation: no palliation/PA band (NO); BT shunt only (BT); or Norwood procedure (NP)...
December 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27470639/alternative-splicing-of-titin-restores-diastolic-function-in-an-hfpef-like-genetic-murine-model-ttn%C3%AE-iajxn
#19
Mathew Bull, Mei Methawasin, Joshua Strom, Pooja Nair, Kirk Hutchinson, Henk Granzier
RATIONALE: Patients with heart failure with preserved ejection fraction (HFpEF) experience elevated filling pressures and reduced ventricular compliance. The splicing factor RNA-binding motif 20 (RBM20) regulates the contour length of titin's spring region and thereby determines the passive stiffness of cardiomyocytes. Inhibition of RBM20 leads to super compliant titin isoforms (N2BAsc) that reduce passive stiffness. OBJECTIVE: To determine the therapeutic potential of upregulating compliant titin isoforms in an HFpEF-like state in the mouse...
September 2, 2016: Circulation Research
https://www.readbyqxmd.com/read/27424315/stress-cardiomyopathy-is-it-limited-to-takotsubo-syndrome-problems-of-definition
#20
REVIEW
Petr A Sarapultsev, Alexey P Sarapultsev
In 2006, Takotsubo syndrome (TTC) was described as a distinct type of stress-induced cardiomyopathy (stress cardiomyopathy). However, when thinking about Takotsubo cardiomyopathy from the viewpoints of the AHA and ESC classifications, 2 possible problems may arise. The first potential problem is that a forecast of disease outcome is lacking in the ESC classification, whereas the AHA only states that 'outcome is favorable with appropriate medical therapy'. However, based on the literature data, one can make a general conclusion that occurrence of myocardial lesions in TTC (i...
October 15, 2016: International Journal of Cardiology
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