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https://www.readbyqxmd.com/read/27926490/positive-regulation-of-taz-expression-by-ebv-lmp1-contributes-to-cell-proliferation-and-epithelial-mesenchymal-transition-in-nasopharyngeal-carcinoma
#1
Jiang He, Feiyu Tang, Liyu Liu, Lin Chen, Jiang Li, Danming Ou, Lu Zhang, Zhi Li, Deyun Feng, Wenzheng Li, Lun-Quan Sun
The Epstein-Barr virus latent membrane protein 1 (LMP1) is an integral membrane protein. LMP1 has been reported to activate the NF-κB and mitogen-activated protein kinase pathways. However, these effects alone are unable to account for the profound oncogenic properties of LMP1. TAZ is one of the nuclear effectors of Hippo-related pathways and highly expressed in many human tumors. Here, we reported that TAZ was frequently expressed in LMP1-positive nasopharyngeal carcinoma. In NPC cell lines, we showed that LMP1 promoted TAZ expression...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27904043/role-of-the-drug-metabolizing-enzyme-cyp-during-mouse-liver-development
#2
Wataru Ochiai, Akiyo Hirose, Taisuke Kawamura, Kyoko Komachi, Yuka Yamamoto, Satoshi Kitaoka, Jo Hatogai, Yoshiki Kusunoki, Risako Kon, Nobutomo Ikarashi, Kiyoshi Sugiyama
The drug-metabolizing enzyme CYP is mainly involved in the metabolism of various substances in the liver, such as drugs, endogenous substances, and carcinogens. Recent reports have also revealed that CYP1B1 plays a major role in the developmental process. Because the level of CYP expression is markedly high in the liver, we hypothesize that CYP plays a role in the developmental process of the liver. To verify this hypothesis, we analyzed the expression patterns of various CYP molecular species and their functions during the differentiation of embryonic stem cells (ES cells) into hepatocytes and the developmental process in mice...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27901106/the-role-of-pim1-pim2-kinases-in-tumors-of-the-male-reproductive-system
#3
Manuel Pedro Jiménez-García, Antonio Lucena-Cacace, María José Robles-Frías, Maja Narlik-Grassow, Carmen Blanco-Aparicio, Amancio Carnero
The PIM family of serine/threonine kinases has three highly conserved isoforms (PIM1, PIM2 and PIM3). PIM proteins are regulated through transcription and stability by JAK/STAT pathways and are overexpressed in hematological malignancies and solid tumors. The PIM kinases possess weak oncogenic abilities, but enhance other genes or chemical carcinogens to induce tumors. We generated conditional transgenic mice that overexpress PIM1 or PIM2 in male reproductive organs and analyzed their contribution to tumorigenesis...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27813122/quercetin-alters-the-dna-damage-response-in-human-hematopoietic-stem-and-progenitor-cells-via-topoii-and-pi3k-dependent-mechanisms-synergizing-in-leukemogenic-rearrangements
#4
Shahar Biechonski, Dana Gourevich, Melanie Rall, Nasma Aqaqe, Muhammad Yassin, Adi Zipin-Roitman, Luba Trakhtenbrot, Leonid Olender, Yael Raz, Ariel J Jaffa, Dan Grisaru, Lisa Wiesmuller, David Elad, Michael Milyavsky
Quercetin (Que) is an abundant flavonoid in the human diet and high-concentration food supplement with reported pro- and anti- carcinogenic activities. Topoisomerase II (TopoII) inhibition and subsequent DNA damage induction by Que was implicated in the Mixed Lineage Leukemia gene (MLL) rearrangements that can induce infant and adult leukemias. This notion raised concerns regarding possible genotoxicities of Que in Hematopoietic Stem and Progenitor Cells (HSPCs). However, molecular targets mediating Que effects on DNA repair relevant to MLL translocations have not been defined...
November 3, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27742691/exposure-to-polychlorinated-biphenyls-and-prostate-cancer-population-based-prospective-cohort-and-experimental-studies
#5
Imran Ali, Bettina Julin, Anders Glynn, Johan Högberg, Marika Berglund, Jan-Erik Johansson, Swen-Olof Andersson, Ove Andrén, Edward Giovannucci, Alicja Wolk, Ulla Stenius, Agneta Åkesson
Polychlorinated biphenyls (PCBs) are highly persistent environmental pollutants and are undesirable components of our daily food. PCBs are classified as human carcinogens, but the evidence for prostate cancer is limited and available data are inconsistent. We explored the link between non-dioxin-like PCB and grade of prostate cancer in a prospective cohort as well as in cell experiments. A population-based cohort of 32496 Swedish men aged 45-79 years was followed prospectively through 1998-2011, to assess the association between validated estimates of dietary PCB exposure and incidence of prostate cancer by grade (2789 cases, whereof 1276 low grade, 756 intermediate grade, 450 high grade) and prostate cancer mortality (357 fatal cases)...
December 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27720397/a-local-mechanism-by-which-alcohol-consumption-causes-cancer
#6
Miguel López-Lázaro
Epidemiological data indicate that 5.8% of cancer deaths world-wide are attributable to alcohol consumption. The risk of cancer is higher in tissues in closest contact on ingestion of alcohol, such as the oral cavity, pharynx and esophagus. However, since ethanol is not mutagenic and the carcinogenic metabolite of ethanol (acetaldehyde) is mostly produced in the liver, it is not clear why alcohol use preferentially exerts a local carcinogenic effect. It is well known that ethanol causes cell death at the concentrations present in alcoholic beverages; however, this effect may have been overlooked because dead cells cannot give rise to cancer...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27716309/correlation-of-an-epigenetic-mitotic-clock-with-cancer-risk
#7
Zhen Yang, Andrew Wong, Diana Kuh, Dirk S Paul, Vardhman K Rakyan, R David Leslie, Shijie C Zheng, Martin Widschwendter, Stephan Beck, Andrew E Teschendorff
BACKGROUND: Variation in cancer risk among somatic tissues has been attributed to variations in the underlying rate of stem cell division. For a given tissue type, variable cancer risk between individuals is thought to be influenced by extrinsic factors which modulate this rate of stem cell division. To date, no molecular mitotic clock has been developed to approximate the number of stem cell divisions in a tissue of an individual and which is correlated with cancer risk. RESULTS: Here, we integrate mathematical modeling with prior biological knowledge to construct a DNA methylation-based age-correlative model which approximates a mitotic clock in both normal and cancer tissue...
October 3, 2016: Genome Biology
https://www.readbyqxmd.com/read/27713163/premalignant-alteration-assessment-in-liver-like-tissue-derived-from-embryonic-stem-cells-by-aristolochic-acid-i-exposure
#8
Tong Li, Ke Jin, Dan-Yan Zhu, Lu Li, Zheng Rong Mao, Bo Wen Wu, Yi Fan Wang, Zong Fu Pan, Lan Juan Li, Chun Sheng Xiang, Kun Kai Su, Yi Jia Lou
The in vitro predictive evaluation of chemical carcinogenicity based on hepatic premalignance has so far not been established. Here, we report a novel approach to investigate the premalignant events triggered by human carcinogen aristolochic acid I (AAI) in the liver-like tissue derived from mouse embryonic stem cells. By AAI exposure, the liver-like tissue exhibited the paracrine interleukin-6 phenotypic characteristics. Hepatocytes expressed STAT3/p-STAT3, c-Myc and Lin28B in parallel. Some of them displayed the dedifferentiation characteristics, such as full of α-fetoprotein granules, increase in size, and nucleocytoplasmic shuttle of Oct4...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27677953/epstein-barr-virus-associated-gastric-cancer-and-potential-mechanisms-of-oncogenesis
#9
Ezequiel M Fuentes-Pananá, Abigail Morales-Sánchez
EBV-associated Gastric Cancer (EBVaGC) comprises about 9% of all cases of GC and constitutes a distinct clinicopathological and molecular entity. The pattern of viral expression in EBVaGC cannot be set to any of the previously EBV-associated malignancies. Several lines of evidence support that viral expression in EBVaGC is characterized by high transcription of the BamH1-A rightward transcript (BART), low-levels of EBNA-1 and lack of LMP1. The high transcription activity of the BamH1-A region is importantly directed to express BART miRNAs, supporting a critical role for these miRNAs during epithelial cell infection and carcinogenesis...
September 26, 2016: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/27664423/phip-dss-induced-colon-carcinogenesis-in-cyp1a-humanized-mice-and-the-possible-role-of-lgr5-stem-cells
#10
Jayson X Chen, Hong Wang, Anna Liu, Lanjing Zhang, Kenneth Reuhl, Chung S Yang
In the past decades, experimental rodent models developed to study the pathogenesis of human colorectal cancer (CRC) generally employed synthetic chemical carcinogens or genetic manipulation. Our lab, in order to establish a more physiologically relevant CRC model, recently developed a colon carcinogenesis model induced by the meat-derived dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and promoted by dextran sodium sulfate (DSS)-induced colitis in the cytochrome P450 1A-humanized (hCYP1A) mice...
September 23, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27572126/insight-into-the-role-of-long-noncoding-rna-in-cancer-development-and-progression
#11
C H Li, Y Chen
Long noncoding RNA (LncRNA) is a large class of RNA molecules with size larger than 200 nucleotides. They exhibit cellular functions although having no protein-coding capability. Accumulating evidence suggests that long noncoding RNA play crucial roles in cancer biology. Studies showed that deregulation of lncRNA was frequently observed in various types of cancers which contributed heavily to malignant phenotypical changes. Aberration of lncRNA can be induced by a number of factors such as dysregulated signaling pathway, response to catastrophic effect, viral infection, and contact with carcinogens...
2016: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/27539458/organoid-culture-of-lingual-epithelial-cells-in-a-three-dimensional-matrix
#12
Hiroko Hisha, Hiroo Ueno
A novel lingual epithelial organoid culture system using a three-dimensional (3D) matrix and growth factors has recently been established. In the culture system, organoids with multilayered squamous keratinized epithelium and typical morphological features of filiform papillae are generated from single lingual epithelial cells at a high efficiency. The culture system is created in order to observe the differentiation and maturation process of each lingual epithelial stem cell and to observe abnormal organoid formation from malignant cells obtained from carcinogen-treated mice...
August 19, 2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27538837/mtor-inhibition-prevents-rapid-onset-of-carcinogen-induced-malignancies-in-a-novel-inducible-hpv-16-e6-e7-mouse-model
#13
Juan Luis Callejas-Valera, Ramiro Iglesias-Bartolome, Panomwat Amornphimoltham, Julia Palacios-Garcia, Daniel Martin, Joseph A Califano, Alfredo A Molinolo, J Silvio Gutkind
The rising incidence of human papillomavirus (HPV)-associated malignancies, especially for oropharyngeal cancers, has highlighted the urgent need to understand how the interplay between high-risk HPV oncogenes and carcinogenic exposure results in squamous cell carcinoma (SCC) development. Here, we describe an inducible mouse model expressing high risk HPV-16 E6/E7 oncoproteins in adults, bypassing the impact of these viral genes during development. HPV-16 E6/E7 genes were targeted to the basal squamous epithelia in transgenic mice using a doxycycline inducible cytokeratin 5 promoter (cK5-rtTA) system...
October 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27518906/reproductive-history-and-breast-cancer-prevention
#14
Jose Russo
The hormonal milieu of an early full-term pregnancy induces lobular development, completing the cycle of differentiation of the breast. This process induces a specific genomic signature in the mammary gland that is represented by the stem cell containing a heterochomatin condensed nucleus (HTN). Even though differentiation significantly reduces cell proliferation in the mammary gland, the mammary epithelium remains capable of responding with proliferation to given stimuli, such as a new pregnancy. The stem cell HTN is able to metabolize the carcinogen and repair the induced DNA damage more efficiently than the stem cell containing an euchromatinic structure (EUN), as it has been demonstrated in the rodent experimental system...
July 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27411282/-development-of-hypoxia-inducible-factor-1%C3%AE-in-tissue-engineered-angiogenesis-and-osteogenesis
#15
REVIEW
Dan Zhang, Liling Ren
OBJECTIVE: To review the development and applications of hypoxia-inducible factor la (HIF-1α) in the strategy of tissue engineered angiogenesis and osteogenesis. METHODS: The literature about HIF-1α in tissue engineering technology was reviewed, analyzed, and summarized. RESULTS: HIF-1α plays a key role in arigiogenic-osteogenic coupling, and as an upstream regulator, HIF-1α can regulate the expressions of its target genes related with angiogenesis and osteogenesis...
April 2016: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/27409834/lgr5-stem-cells-and-their-progeny-in-mouse-epidermis-under-regimens-of-exogenous-skin-carcinogenesis-and-their-absence-in-ensuing-skin-tumors
#16
Gerline C van de Glind, Jacoba J Out-Luiting, Heggert G Rebel, Cornelis P Tensen, Frank R de Gruijl
Actively proliferating Lgr5+ skin stem cells are found deep in the hair follicle (HF). These cells renew the HF and drive its expansion in anagen phase. Their long residence and continuous mitotic activity make them prime candidates to transform into skin tumor-initiating cells. This was investigated by subjecting Lgr5-EGFP-Ires-CreERT2/R26R-LacZ mice (haired and hairless) to chemical and UV carcinogenic regimens. In the course of these regimens Lgr5+ cells (EGFP+) remained exclusively located in HFs, and in deep-seated cysts of hairless skin...
July 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27363826/endocrine-disrupting-chemicals-and-skin-manifestations
#17
Qiang Ju, Christos C Zouboulis
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin...
June 30, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27345199/evaluating-biomarkers-to-model-cancer-risk-post-cosmic-ray-exposure
#18
REVIEW
Deepa M Sridharan, Aroumougame Asaithamby, Steve R Blattnig, Sylvain V Costes, Paul W Doetsch, William S Dynan, Philip Hahnfeldt, Lynn Hlatky, Yared Kidane, Amy Kronenberg, Mamta D Naidu, Leif E Peterson, Ianik Plante, Artem L Ponomarev, Janapriya Saha, Antoine M Snijders, Kalayarasan Srinivasan, Jonathan Tang, Erica Werner, Janice M Pluth
Robust predictive models are essential to manage the risk of radiation-induced carcinogenesis. Chronic exposure to cosmic rays in the context of the complex deep space environment may place astronauts at high cancer risk. To estimate this risk, it is critical to understand how radiation-induced cellular stress impacts cell fate decisions and how this in turn alters the risk of carcinogenesis. Exposure to the heavy ion component of cosmic rays triggers a multitude of cellular changes, depending on the rate of exposure, the type of damage incurred and individual susceptibility...
June 2016: Life Sciences in Space Research
https://www.readbyqxmd.com/read/27345141/preemptive-bone-marrow-transplantation-and-event-free-survival-in-fanconi-anemia
#19
Nicholas E Khan, Philip S Rosenberg, Blanche P Alter
Fanconi anemia (FA) is a rare inherited bone marrow failure syndrome associated with high risks of severe bone marrow failure (BMF), acute myeloid leukemia (AML), and solid tumors (ST). Bone marrow transplantation (BMT) provides a theoretical cure for hematologic risks (BMF, AML), but it introduces uncertain risks of transplantation-related mortality (TRM) and carcinogenicity. We developed a mathematical (Markov) decision model to estimate event-free survival (EFS) conditional on age based on per-year cause-specific hazard rates...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27341837/the-importance-of-stem-cell-engineering-in-head-and-neck-oncology
#20
REVIEW
Wojciech Barczak, Pawel Golusiński, Lukasz Luczewski, Wiktoria M Suchorska, Michal M Masternak, Wojciech Golusiński
Head and neck squamous cell carcinoma is the sixth leading cause of cancer worldwide. The most common risk factors are carcinogens (tobacco, alcohol), and infection of the human papilloma virus. Surgery is still considered as the treatment of choice in case of head and neck cancer, followed by a reconstructive surgery to enhance the quality of life in the patients. However, the widespread use of artificial implants does not provide appropriate physiological activities and often cannot act as a long-term solution for the patients...
October 2016: Biotechnology Letters
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