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https://www.readbyqxmd.com/read/29777335/a-trisubstituted-pyrazole-derivative-reduces-dmba-induced-mammary-tumor-growth-in-rats-by-inhibiting-estrogen-receptor-%C3%AE-expression
#1
Hanumappa Ananda, Kothanahally S Sharath Kumar, Muddenahalli S Sudhanva, Shobith Rangappa, Kanchugarakoppal S Rangappa
Aberrant expression of estrogen receptor alpha (ER-α) is observed in many pathological complications like breast cancer, endometrial cancer, and in osteoporosis. ER-α plays a vital role in the initiation and progression of breast cancer and confers chemo and radioresistance to the cancer cells by upregulating expression of anti-apoptotic proteins. The synthetic pyrazole derivative 3-(1-(4-bromophenyl)-5-phenyl-1H-pyrazol-3-yl)pyridine (compound 5d) displays significant cytotoxicity against mammary carcinoma cells...
May 18, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29772942/modulation-of-xenobiotic-metabolizing-enzyme-activities-in-rat-liver-by-co-administration-of-morin-endosulfan-and-7-12-dimethylbenz-a-anthracene
#2
Canan Sapmaz, Tulin Firat, Aysel Kukner, Azra Bozcaarmutlu
Morin is a flavonoid which is present in many plants. Endosulfan and 7,12-dimethylbenz[a]anthracene (DMBA) are toxic chemicals that humans are exposed to in their daily lives. In this study, the protective role of morin was investigated in endosulfan and DMBA treated rats. Eight groups, each comprising seven 2.5-month-old adult male Wistar rats (weighing 170-255 g), were used. Endosulfan, morin, and DMBA were administered individually or in combinations, at 5 mg/kg body weight (bw) (three times/week), 25 mg/kg bw (three times/week), and 30 mg/kg bw (once/week for three weeks) via oral gavage, respectively...
May 18, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29770327/-in-vitro-cytotoxicity-and-in-vivo-antimammary-tumor-effects-of-the-hydroethanolic-extract-of-acacia-seyal-mimosaceae-stem-bark
#3
Stephane Zingue, Amstrong Nang Njuh, Alain Brice Tueche, Jeremie Tamsa, Edwige Nana Tchoupang, Stanislas Djaouli Kakene, Marius Trésor Kemegne Sipping, Dieudonné Njamen
The present study was designed to evaluate the in vitro and in vivo antitumor effects of A. seyal hydroethanolic extract on breast cancer. The cytotoxicity of A. seyal extract was evaluated using resazurin reduction assay in 9 cell lines. Further, the protective effect of the hydroethanolic extract of A. seyal stem barks was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast cancer rat model. Incidence, burden, volume, and histological analysis of mammary tumors were measured. The Acacia seyal extract exhibited CC50 of 100 in MCF-7 cells after 24 h...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29763690/the-citrus-flavonone-hesperetin-attenuates-the-nuclear-translocation-of-aryl-hydrocarbon-receptor
#4
Yan Qin Tan, Leo Clement Chiu-Leung, Shu-Mei Lin, Lai K Leung
The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR. Hesperetin is a flavonone found abundantly in citrus fruits and has been shown to be a biologically active agent. In the present study, the effect of hesperetin on the nuclear translocation of AhR and the downstream gene expression was investigated in MCF-7 cells. Confocal microscopy indicated that 7, 12-dimethylbenz[α]anthracene (DMBA) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) -induced nuclear translocation of AhR was deterred by hesperetin treatment...
May 16, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29748834/qbd-based-development-of-%C3%AE-linolenic-acid-potentiated-nanoemulsion-for-targeted-delivery-of-doxorubicin-in-dmba-induced-mammary-gland-carcinoma-in-vitro-and-in-vivo-evaluation
#5
Chandra Bhushan Tripathi, Poonam Parashar, Malti Arya, Mahendra Singh, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
Breast cancer is the most common cancer of occurrence in women and has the highest mortality incidence rate therein. The present study envisaged to develop doxorubicin (Dox) loaded folate functionalized nanoemulsion (NE) for profound therapeutic activity against mammary gland cancer. NE was prepared using pseudo-ternary phase diagrams utilizing α-linolenic acid (ALA) as lipid phase, to further enhance the anticancer potential of Dox. Box-Behnken design was employed to systematically develop the NE. Optimized NE (f-Dox-NE) was evaluated for in vitro and in vivo performance...
May 10, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29716865/the-increasing-of-catalase-activity-in-dimethylbenz-%C3%AE-anthracene-dmba-induced-rat-treated-by-hibiscus-sabdariffa-l-extract
#6
- Nurkhasanah, Nanik Sulistyani, Ery Fatmawati
The objective of the present study was to characterize the activity and expression of catalase enzymes in Hibiscus sabdariffa L (rosella) extract treated rat induced by dimethylbenz-α-anthracene (DMBA) and to evaluate the relationship between the catalase activity and histopathological characteristics of liver organ. The 25 animals were divided randomly into 5 groups: the normal group, the negative control group, and treated groups, which treated by rosella extract with variation of dose of 10, 50 and 100mg/kgBW/day for 35 days...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29715754/in-vivo-evaluation-of-antitumoral-and-antiangiogenic-effect-of-imiquimod-loaded-polymeric-nanoparticles
#7
Marina França Dias, Bruna Caroline Pinheiro de Figueiredo, Júlia Teixeira-Neto, Maria Carolina Andrade Guerra, Silvia Ligório Fialho, Armando Silva Cunha
The chemotherapeutic agent imiquimod (Imq) is used to treat skin cancers, the most common type of human cancer. However, the high incidence of local and systemic side effects associated with its use as well as its low skin permeation impair patient compliance and therapeutic effectiveness To overcome these limitations, nanostructured systems such as nanoparticles can be a promising alternative. Nanoparticles are submicron particles (size less than 1000 nm) with high surface area that facilitates the interaction and cellular uptake by biological membranes...
April 27, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29693192/salidroside-prevents-skin-carcinogenesis-induced-by-dmba-tpa-in-a-mouse-model-through-suppression-of-inflammation-and-promotion-of-apoptosis
#8
Ying-Hui Kong, Su-Ping Xu
Salidroside (SR) is a main component of Rhodiola rosea L. and exhibits a variety of pharmacologic properties. The present study was carried out to explore the potential effect of SR against skin cancer induced by 7,12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13‑acetate (TPA) in female Institute for Cancer Research (ICR) mice and to reveal the underlying molecular targets regulated by SR. The mice were randomly divided into 4 groups: control, DMBA/TPA, DMBA/TPA+SR (20 mg/kg) and DMBA/TPA+SR (40 mg/kg)...
April 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29691438/the-hippo-signaling-transducer-taz-regulates-mammary-gland-morphogenesis-and-carcinogen-induced-mammary-tumorigenesis
#9
Kayla E Denson, Ashley L Mussell, He Shen, Alexander Truskinovsky, Nuo Yang, Natesh Parashurama, Yanmin Chen, Costa Frangou, Fajun Yang, Jianmin Zhang
Hippo signaling pathway is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis and stem cell self-renewal. TAZ (transcriptional coactivator with the PDZ-binding motif) is a key downstream effector of the mammalian Hippo pathway. Here, using a transgenic mouse model with mammary-gland-specific expression of constitutively active TAZ, we found that TAZ induction in mammary epithelial cells was associated with an increase in mammary glandular size, which probably resulted from adipocyte hypertrophy...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29684509/detection-of-lindane-and-7-12-dimethylbenz-a-anthracene-toxicity-at-low-concentrations-in-a-three-dimensional-ovarian-follicle-culture-system
#10
Hong Zhou, Cara J Young, Rita Loch-Caruso, Ariella Shikanov
Exposure to environmental toxicants that target ovarian follicles can have long-lasting effects on women's reproductive health and health of the offspring. Experiments in rodents have contributed knowledge about the effects of individual toxicants on ovarian follicles. However, little is known about the effects of mixtures of toxicants on ovarian follicular health. We studied the combined effects of low, physiologically- and environmentally-relevant concentrations of toxicants on murine secondary ovarian follicles cultured in an encapsulated three-dimensional (3D) system...
April 20, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29674280/the-chemotherapeutic-effect-of-%C3%AE-2-himachalen-6-ol-in-chemically-induced-skin-tumorigenesis
#11
Hamid E Daaboul, Carole Dagher, Robin I Taleb, Kikki Bodman-Smith, Wassim N Shebaby, Mirvat El-Sibai, Mohamad A Mroueh, Costantine F Daher
β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect on papillomas induced using a DMBA/TPA skin carcinogenesis mouse model. HaCaT-ras II-4 epidermal squamous cell viability was assessed using WST-1 kit. Cell cycle was analyzed by flow cytometry, and pro/anti-apoptotic proteins were measured using western blot. Mice papillomas were induced by DMBA and promoted with TPA for 18 weeks...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29663660/7-12-dimethylbenz-%C3%AE-anthracene-increases-cell-proliferation-and-invasion-through-induction-of-wnt-%C3%AE-catenin-signaling-and-emt-process
#12
Yeo-Jung Kwon, Dong-Jin Ye, Hyoung-Seok Baek, Young-Jin Chun
7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanism of DMBA, we explored its effects in the breast cancer cell lines, MCF-7 and MDA-MB-231, and the cervical cancer cell line, HeLa. Cell viability assay and measurement of a proliferation marker showed that DMBA markedly increased cancer cell proliferation...
April 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29651207/protective-effect-of-allyl-isothiocyanate-on-glycoprotein-components-in-7-12-dimethylbenz-a-anthracene-induced-mammary-carcinoma-in-rats
#13
Thangarasu Rajakumar, Pachaiappan Pugalendhi, Subbaiyan Thilagavathi
The present study aimed to investigate the protective effect of allyl isothiocyanate (AITC) on glycoprotein components in 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female Sprague-Dawley rats. Mammary tumor was induced by a single dose of DMBA (25 mg/rat) injected subcutaneously near mammary gland. The levels of glycoprotein components such as hexose, hexosamine and sialic acid were analyzed colorimetrically in plasma, mammary and liver tissues. We observed an increased levels of glycoprotein components in plasma, mammary and liver tissues in cancer bearing rats...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29609579/euterpe-oleracea-extract-inhibits-tumorigenesis-effect-of-the-chemical-carcinogen-dmba-in-breast-experimental-cancer
#14
Jéssica Alessandra-Perini, Jamila Alessandra Perini, Karina Cristina Rodrigues-Baptista, Roberto Soares de Moura, Antonio Palumbo Junior, Thiago Alves Dos Santos, Pergentino José Cunha Souza, Luiz Eurico Nasciutti, Daniel Escorsim Machado
BACKGROUND: Among the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) and macrophages. Recently, the extract of Euterpe oleracea (açaí), a fruit that is widely found in the Amazon region, already showed antitumorigenic effects in vitro in human breast cancer cell lines. The present study aimed to investigate the effect of açaí on breast cancer using a chemically DMBA (7,12-dimethylbenzanthracene) experimental model...
April 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29579155/a-polymorphism-in-the-lysyl-oxidase-propeptide-domain-accelerates-carcinogen-induced-cancer
#15
Ana de la Cueva, Michael Emmerling, Sarah L Lim, Shi Yang, Philip C Trackman, Gail E Sonenshein, Kathrin H Kirsch
The propeptide (LOX-PP) domain of the lysyl oxidase proenzyme (Pro-LOX) was shown to inhibit the transformed phenotype of breast, lung and pancreatic cells in culture and the formation of Her2/neu-driven breast cancer in a xenograft model. A single nucleotide polymorphism (SNP, rs1800449) positioned in a highly conserved region of LOX-PP results in an Arg158Gln substitution (humans). This ArgGln substitution profoundly impaired the ability of LOX-PP to inhibit the invasive phenotype and xenograft tumor formation...
March 22, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29559340/epidermal-fatty-acid-binding-protein-prevents-chemical-induced-skin-tumorigenesis-by-regulation-of-tpa-induced-ifn-p53-sox2-pathway-in-keratinocytes
#16
Yuwen Zhang, Jiaqing Hao, Jun Zeng, Qiang Li, Enyu Rao, Yanwen Sun, Lianliang Liu, Anita Mandal, V Douglas Landers, Rebecca J Morris, Margot P Cleary, Jill Suttles, Bing Li
Skin lipids (e.g. fatty acids) are essential for normal skin functions. Epidermal fatty acid-binding protein (E-FABP) is the predominant FABP expressed in skin epidermis. However, the role of E-FABP in skin homeostasis and pathology remains largely unknown. Herein, we utilized the 7,12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanolyphorbol-13-acetate (TPA)-induced skin tumorigenesis model to assess the role of E-FABP in chemical-induced skin tumorigenesis. Compared to their wild type (WT) littermates, mice deficient in E-FABP, but not adipose FABP (A-FABP), developed more skin tumors with higher incidence...
March 17, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29535128/rip1-hat1-sirt-complex-identification-and-targeting-in-treatment-and-prevention-of-cancer
#17
Vincenzo Carafa, Angela Nebbioso, Francesca Cuomo, Dante Rotili, Gilda Cobellis, Paola Bontempo, Alfonso Baldi, Enrico P Spugnini, Gennaro Citro, Angela Chambery, Rosita Russo, Menotti Ruvo, Paolo Ciana, Luca Maravigna, Jani Shaik, Enrico Radaelli, Pasquale De Antonellis, Domenico Tarantino, Adele Pirolli, Rino Ragno, Massimo Zollo, Hendrik G Stunnenberg, Antonello Mai, Lucia Altucci
Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes. Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in cell death induction, using different methods as flow cytometry, transcriptome analysis, immunoprecipitation, enzymatic assays, transfections, mutagenesis, and in vivo studies with different mice models. Results: Here, we show that RIP1 is highly expressed in cancer, and we define a novel RIP1/3-SIRT1/2-HAT1/4 complex...
March 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29525432/marliolide-inhibits-skin-carcinogenesis-by-activating-nrf2-are-to-induce-heme-oxygenase-1
#18
June Lee, Karabasappa Mailar, Ok-Kyung Yoo, Won Jun Choi, Young-Sam Keum
Heme oxygenase-1 (HO-1) catalyzes the enzymatic degradation of heme to produce three anti-oxidant molecules: carbon monoxide (CO), ferrous ion (Fe2+ ), and biliverdin. Induction of HO-1 is currently considered as a feasible strategy to treat oxidative stress-related diseases. In the present study, we identified marliolide as a novel inducer of HO-1 in human normal keratinocyte HaCaT cells. Mechanism-based studies demonstrated that the induction of HO-1 by marliolide occurred through activation of NRF2/ARE via direct binding of marliolide to KEAP1...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29500540/evaluation-of-the-chemopreventive-effects-of-ankaferd-bloodstopper-in-7-12-dimethylbenz-a-anthracene-induced-oral-epithelial-dysplasia
#19
Murat Ozle, Dilek A Uğar Çankal, Mert Ilhan, Hikmet Keleş, Esra Küpeli Akkol
OBJECTIVES: Ankaferd BloodStopper® (ABS) is an herbal extract which has been used historically as a hemostatic agent in traditional Turkish medicine. ABS comprises of standardized mixture of herbs Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica. In addition to its hemostatic effects, the herb ABS contains some other biological effects including antioxidant and antitumoral properties. The aim of this study is to investigate the chemopreventive effects of ABS in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral epithelial dysplasia...
March 2, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29498408/genetic-polymorphisms-and-protein-expression-of-p53-and-brca1-in-preneoplastic-and-neoplastic-rat-mammary-glands
#20
Wafa Al-Dhaheri, Imam Hassouna, Sherif M Karam
Breast cancer is the most common type of cancer and the leading cause of cancer-related deaths among women in the United Arab Emirates and worldwide. Although many factors contribute to the high incidence of breast cancer, a considerable number of cases are related to environmental factors. In the present study, breast cancer was induced in female rats using a single dose, 80 mg/kg body wt, of the environmental carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). The aim of the present study, was to characterize some of the molecular changes that occur during breast cancer development in the DMBA-treated rat model...
May 2018: Oncology Reports
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