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https://www.readbyqxmd.com/read/28453945/an-approach-to-reconciling-competing-ethical-principles-in-aggregating-heterogeneous-health-preferences
#1
Barry Dewitt, Alexander Davis, Baruch Fischhoff, Janel Hanmer
BACKGROUND: Health-related quality of life (HRQL) scores are used extensively to quantify the effectiveness of medical interventions. Societal preference-based HRQL scores aim to produce societal valuations of health by aggregating valuations from individuals in the general population, where each aggregation procedure embodies different ethical principles, as explained in social choice theory. METHODS: Using the Health Utilities Index as an exemplar, we evaluate societal preference-based HRQL measures in the social choice theory framework...
April 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28453338/the-stener-lesion-historical-perspective-and-evolution-of-diagnostic-criteria
#2
Meghan E Lark, Brianna L Maroukis, Kevin C Chung
BACKGROUND: In 1962, Bertil Stener first described the anatomy and treatment of the displaced ulnar collateral ligament of the metacarpophalangeal joint, later called the Stener lesion. Since Stener's publication, treatment algorithms for ulnar collateral ligament rupture have aided in preoperative diagnosis, yet the best diagnostic method to assess ligament displacement remains largely undefined. METHODS: An extensive literature search was performed to explore the treatment evolution of the Stener lesion and explore how technical development has influenced Stener lesion diagnosis...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28448916/on-the-necessity-of-improving-the-environmental-impacts-of-furniture-and-appliances-in-net-zero-energy-buildings
#3
Endrit Hoxha, Thomas Jusselme
There is now clear evidence regarding the extensive use of furniture and appliances in daily human life, but there is less evidence of their impact on the environment. Responding to this gap in knowledge, this study focuses on an assessment of the environmental impacts of furniture and appliances as used in highly energy efficient buildings. Their primary energy, non-renewable energy and global warming potential indicators have been assessed by extending the boundaries of the Life Cycle Assessment (LCA) study beyond the building itself...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448759/ft3-is-higher-in-males-than-in-females-and-decreases-over-the-lifespan
#4
David Strich, Gilad Karavani, Shalom Edri, Cherut Chay, David Gillis
OBJECTIVE: Normal changes in Free triiodothyronine (FT3), Free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels over the lifespan and differences between genders are not well documented, mainly because even the largest-scale studies available include relatively small cohorts. The aim of this study was to define age-related trends including gender differences based on reliable data. METHODS: A large database including serum thyroid tests drawn in community clinics was studied...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28448707/-joint-replacement-and-giant-cell-tumor-report-of-8-cases
#5
J G Martínez-Estrada, O Santamaría-Bahena
INTRODUCTION: The giant-cell tumor is an aggressive neoplasia, represents approximately from the 5 the 8.6% of primary bone tumors; more of 50% affects the pelvic extremity, being able to affect the totality of the bones. OBJECTIVE: To present the case series of tumors around the knee and hip that we offered a tumoral joint replacement as an alternative to amputation. MATERIAL AND METHODS: We present eight cases of extensive giant cells tumors, we did en bloc resection and tumoral joint replacement...
September 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28448154/improving-lithium-sulfur-battery-performance-under-lean-electrolyte-through-nanoscale-confinement-in-soft-swellable-gels
#6
Junzheng Chen, Wesley A Henderson, Huilin Pan, Brian R Perdue, Ruiguo Cao, Jian Zhi Hu, Chuan Wan, Kee Sung Han, Karl T Mueller, Ji-Guang Zhang, Yuyan Shao, Jun Liu
Li-S batteries have been extensively studied using rigid carbon as the host for sulfur encapsulation, but improving the properties with a reduced electrolyte amount remains a significant challenge. This is critical for achieving high energy density. Here, we developed a soft PEO10LiTFSI polymer swellable gel as a nanoscale reservoir to trap the polysulfides under lean electrolyte conditions. The PEO10LiTFSI gel immobilizes the electrolyte and confines polysulfides within the ion conducting phase. The Li-S cell with a much lower electrolyte to sulfur ratio (E/S) of 4 gE/gS (3...
April 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28447919/postpartum-dyspareunia-and-sexual-functioning-a-prospective-cohort-study
#7
Liesbet Lagaert, Steven Weyers, Helena Van Kerrebroeck, Els Elaut
OBJECTIVES: Sexual functioning is an important concern for women in the postpartum period. The aim of this research was to investigate the prevalence and determinants of dyspareunia and sexual dysfunction before and after childbirth. METHODS: Between November 2013 and April 2014, 109 women in their third trimester of pregnancy were enrolled in a prospective cohort study at Ghent University Hospital. Dyspareunia, sexual functioning and quality of life (QOL) were evaluated at enrolment and again 6 weeks and 6 months postpartum...
April 27, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28447914/diagnosis-of-life-threatening-alpha-gal-food-allergy-appears-to-be-patient-driven
#8
Mary Grace Flaherty, Samantha Jan Kaplan, Maya R Jerath
OBJECTIVE: Patients exhibiting life-threatening symptoms associated with the alpha-gal food allergy (delayed urticaria or anaphylaxis due to mammalian meat) are frequently undiagnosed, causing unnecessary emergency department (ED) and health care visits, and extensive pain and suffering. This study aimed to determine the path to diagnosis experienced by alpha-gal patients. METHODS: Semistructured interviews were conducted from March to June 2016 with a chronological systematic sample of approximately 10% of patients diagnosed with alpha-gal and treated by the University of North Carolina Allergy and Immunology Clinic (n = 28)...
April 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/28447881/clinical-and-duplex-ultrasound-evaluation-of-lower-extremities-varicose-veins-a-practical-guideline
#9
Luca Spinedi, Pavel Broz, Rolf Peter Engelberger, Daniel Staub, Heiko Uthoff
Lower extremities varicose veins are among the most frequent diseases in the general population. They can cause complaints with a deterioration of the quality of life and are associated with potentially threatening clinical conditions such as chronic venous ulceration, haemorrhage from ruptured varicose veins, and venous thromboembolism. An accurate diagnostic work-up is crucial to confirm the presence and the extension of the venous problem, in order to obtain an optimal management of the condition. In the past years, great efforts have been made to reach an international consensus on the terminology, the symptomatology, the classification, and the duplex ultrasound examination of lower extremities varicose veins...
April 27, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28447615/millions-of-boreal-shield-lakes-can-be-used-to-probe-archaean-ocean-biogeochemistry
#10
S L Schiff, J M Tsuji, L Wu, J J Venkiteswaran, L A Molot, R J Elgood, M J Paterson, J D Neufeld
Life originated in Archaean oceans, almost 4 billion years ago, in the absence of oxygen and the presence of high dissolved iron concentrations. Early Earth oxidation is marked globally by extensive banded iron formations but the contributing processes and timing remain controversial. Very few aquatic habitats have been discovered that match key physico-chemical parameters of the early Archaean Ocean. All previous whole ecosystem Archaean analogue studies have been confined to rare, low sulfur, and permanently stratified lakes...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446711/chemical-roots-of-biological-evolution-the-origins-of-life-as-a-process-of-development-of-autonomous-functional-systems
#11
REVIEW
Kepa Ruiz-Mirazo, Carlos Briones, Andrés de la Escosura
In recent years, an extension of the Darwinian framework is being considered for the study of prebiotic chemical evolution, shifting the attention from homogeneous populations of naked molecular species to populations of heterogeneous, compartmentalized and functionally integrated assemblies of molecules. Several implications of this shift of perspective are analysed in this critical review, both in terms of the individual units, which require an adequate characterization as self-maintaining systems with an internal organization, and also in relation to their collective and long-term evolutionary dynamics, based on competition, collaboration and selection processes among those complex individuals...
April 2017: Open Biology
https://www.readbyqxmd.com/read/28446628/plasma-ferritin-and-hepcidin-are-lower-at-4-months-postpartum-among-women-with-elevated-c-reactive-protein-or-%C3%AE-1-acid-glycoprotein
#12
Josh M Jorgensen, Zhenyu Yang, Bo Lönnerdal, Caroline J Chantry, Kathryn G Dewey
Background: Ferritin and hepcidin are markers of iron status that typically increase during inflammation or infection. The postpartum period is a physiologically unique life stage in which the relations between these proteins and other markers of inflammation have not been extensively studied.Objective: We aimed to determine whether 2 markers of inflammation [high-sensitivity C-reactive protein (CRP) and α1-acid glycoprotein (AGP)] were associated with ferritin or hepcidin in postpartum women in California...
April 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28446517/a-novel-%C3%AE-calcitonin-gene-related-peptide-analogue-protects-against-end-organ-damage-in-experimental-hypertension-cardiac-hypertrophy-and-heart-failure
#13
Aisah A Aubdool, Pratish Thakore, Fulye Argunhan, Sarah-Jane Smillie, Moritz Schnelle, Salil Srivastava, Khadija M Alawi, Elena Wilde, Jennifer Mitchell, Keith Farrell-Dillon, Daniel A Richards, Giuseppe Maltese, Richard C Siow, Manasi Nandi, James E Clark, Ajay M Shah, Anette Sams, Susan D Brain
Background -Research into the therapeutic potential of α-calcitonin gene-related peptide (α-CGRP) has been limited due to its peptide nature and short half-life. Here, we evaluate whether a novel potent and long lasting (t½ ≥ 7h) acylated α-CGRP analogue (αAnalogue) could alleviate and reverse cardiovascular disease in two distinct murine models of hypertension and heart failure in vivoMethods -The ability of the αAnalogue to act selectively via the CGRP pathway was shown in skin using a CGRP receptor antagonist...
April 26, 2017: Circulation
https://www.readbyqxmd.com/read/28446512/molecular-mechanisms-facilitating-the-initial-kinetochore-encounter-with-spindle-microtubules
#14
Vanya Vasileva, Marek Gierlinski, Zuojun Yue, Nicola O'Reilly, Etsushi Kitamura, Tomoyuki U Tanaka
The initial kinetochore (KT) encounter with a spindle microtubule (MT; KT capture) is one of the rate-limiting steps in establishing proper KT-MT interaction during mitosis. KT capture is facilitated by multiple factors, such as MT extension in various directions, KT diffusion, and MT pivoting. In addition, KTs generate short MTs, which subsequently interact with a spindle MT. KT-derived MTs may facilitate KT capture, but their contribution is elusive. In this study, we find that Stu1 recruits Stu2 to budding yeast KTs, which promotes MT generation there...
April 26, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28445733/nf-%C3%AE%C2%BAb-immunity-in-the-brain-determines-fly-lifespan-in-healthy-aging-and-age-related-neurodegeneration
#15
Ilias Kounatidis, Stanislava Chtarbanova, Yang Cao, Margaret Hayne, Dhruv Jayanth, Barry Ganetzky, Petros Ligoxygakis
During aging, innate immunity progresses to a chronically active state. However, what distinguishes those that "age well" from those developing age-related neurological conditions is unclear. We used Drosophila to explore the cost of immunity in the aging brain. We show that mutations in intracellular negative regulators of the IMD/NF-κB pathway predisposed flies to toxic levels of antimicrobial peptides, resulting in early locomotor defects, extensive neurodegeneration, and reduced lifespan. These phenotypes were rescued when immunity was suppressed in glia...
April 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28445647/how-will-copper-contamination-constrain-future-global-steel-recycling
#16
Katrin Ellen Daehn, Andre Cabrera Serrenho, Julian M Allwood
Copper in steel causes metallurgical problems, but is pervasive in end-of-life scrap and cannot currently be removed commercially once in the melt. Contamination can be managed to an extent by globally trading scrap for use in tolerant applications and dilution with primary iron sources. However, the viability of long-term strategies can only be evaluated with a complete characterization of copper in the global steel system and this is presented in this paper. The copper concentration of flows along the 2008 steel supply chain is estimated from a survey of literature data and compared with estimates of the maximum concentration that can be tolerated in steel products...
April 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28444377/primary-chondrosarcoma-of-the-trachea-with-extensive-extralumenal-growth
#17
Andrey Ryabov, Oleg Pikin, Victor Sokolov, Nadezda Volchenko
Primary chondrosarcoma of the trachea is an extremely rare non-epithelial neoplasm with only few cases published in the literature. We present a rare case of tracheal chondrosarcoma with extensive extralumenal growth. We operated a patient with obstructive tumour of the upper third of the trachea via partial sternotomy. Before surgery, a Hanarostent was put into the trachea to treat a life-threatening stenosis. Postoperative period was uneventful. We discuss the incidence, clinical presentation and treatment options in patients with rare tracheal tumours...
April 20, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28444241/cervical-spine-muscle-tendon-unit-length-differences-between-neutral-and-forward-head-postures-biomechanical-study-using-human-cadaveric-specimens
#18
Saeed Khayatzadeh, Olivia A Kalmanson, Dale Schuit, Robert M Havey, Leonard I Voronov, Alexander J Ghanayem, Avinash G Patwardhan
Background: Forward Head Posture (FHP) may be associated with neck pain and poor health-related quality of life. Literature describes only qualitative muscle length changes associated with FHP. Objective: To quantify how muscle-tendon unit lengths are altered when human cadaveric specimens are placed in alignments representing different severities of FHP. Design: Biomechanical study using 13 fresh-frozen cadaveric cervical spine specimens (Occiput-T1, 54±15yrs)...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28442212/effects-of-underwater-ultrasound-therapy-on-pain-inflammation-hand-function-and-quality-of-life-in-patients-with-rheumatoid-arthritis-a-randomized-controlled-trial
#19
Márta Király, Zsuzsanna Varga, Ferenc Szanyó, Rita Kiss, Katalin Hodosi, Tamás Bender
OBJECTIVES: To investigate the effects of underwater ultrasound (US) therapy in 48 patients with moderately active rheumatoid arthritis (disease activity score in 28 joints [DAS28]>3.2 and<5.1). METHODS: Patients randomly assigned to the ultrasound group (n=25) received underwater continuous ultrasound therapy to both wrists and hands for 7min per session with an intensity of 0.7W/cm(2) for 10 sessions. The control group (n=23) received sham treatment under the same conditions...
April 13, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28441986/medical-therapy-versus-dietary-avoidance-in-eosinophilic-esophagitis-which-approach-is-better
#20
Mirna Chehade, Ellen Sher
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease characterized by esophageal symptoms and esophageal eosinophilia. It is induced by food triggers and by environmental allergens in some patients. No U.S. Food and Drug Administration approved therapies exist for patients with EoE. Common therapies include topical corticosteroids (TCS) and dietary restriction. METHODS: This article reviewed the pros and cons of a medical versus dietary approach in treating EoE in children and adults...
May 1, 2017: Allergy and Asthma Proceedings:
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