keyword
https://read.qxmd.com/read/38436726/factors-associated-with-successful-liberation-from-continuous-renal-replacement-therapy-in-children-and-young-adults-analysis-of-the-worldwide-exploration-of-renal-replacement-outcomes-collaborative-in-kidney-disease-registry
#1
JOURNAL ARTICLE
Erin K Stenson, Issa Alhamoud, Rashid Alobaidi, Gabriella Bottari, Sarah Fernandez, Dana Y Fuhrman, Francesco Guzzi, Taiki Haga, Ahmad Kaddourah, Eleonora Marinari, Tahagod Mohamed, Catherine Morgan, Theresa Mottes, Tara Neumayr, Nicholas J Ollberding, Valeria Raggi, Zaccaria Ricci, Emily See, Natalja L Stanski, Huaiyu Zang, Emily Zangla, Katja M Gist
PURPOSE: Continuous renal replacement therapy (CRRT) is used for supportive management of acute kidney injury (AKI) and disorders of fluid balance (FB). Little is known about the predictors of successful liberation in children and young adults. We aimed to identify the factors associated with successful CRRT liberation. METHODS: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease study is an international multicenter retrospective study (32 centers, 7 nations) conducted from 2015 to 2021 in children and young adults (aged 0-25 years) treated with CRRT for AKI or FB disorders...
March 4, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38360044/high-dose-intravenous-immunoglobulin-versus-albumin-4-in-paediatric-toxic-shock-syndrome-a-randomised-controlled-feasibility-study
#2
JOURNAL ARTICLE
Aurélie Portefaix, Carole Dhelens, Morgan Recher, Fleur Cour-Andlauer, Jérôme Naudin, Guillaume Mortamet, Nicolas Joram, Pierre Tissières, Tiphanie Ginhoux, Behrouz Kassai, Florent Boutitie, Delphine Maucort-Boulch, Etienne Javouhey
PURPOSE: Toxic shock syndrome (TSS) is a rare disease responsible for significant morbidity and mortality. Intravenous immunoglobulin (IG) therapy in paediatric TSS could improve shock and organ failure, but more consistent efficacy and safety data are needed. Our objective was to determine whether a randomised clinical trial (RCT) assessing intravenous IG in TSS in children is feasible. METHODS: We performed a multicentre, feasibility, double-blind RCT assessing efficacy of high-dose intravenous IG versus albumin 4% (control group) within the first 12 hours of shock onset...
February 15, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38353586/association-of-an-in-hospital-desirability-of-outcomes-ranking-scale-with-postdischarge-health-related-quality-of-life-a-secondary-analysis-of-the-life-after-pediatric-sepsis-evaluation
#3
JOURNAL ARTICLE
Grace E Logan, Russell K Banks, Ron Reeder, Kristen Miller, Peter M Mourani, Tellen D Bennett, Stephanie L Bourque, Kathleen L Meert, Jerry Zimmerman, Aline B Maddux
OBJECTIVES: To develop a desirability of outcome ranking (DOOR) scale for use in children with septic shock and determine its correlation with a decrease in 3-month postadmission health-related quality of life (HRQL) or death. DESIGN: Secondary analysis of the Life After Pediatric Sepsis Evaluation prospective study. SETTING: Twelve U.S. PICUs, 2013-2017. PATIENTS: Children (1 mo-18 yr) with septic shock. INTERVENTIONS: None...
February 14, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38074971/clinical-profile-of-children-with-burns-in-a-tertiary-care-hospital
#4
K Yashaswini, A V Lalitha, Gs Naresh Kanna, Abha Rani Kujur, Raj John A Michael
BACKGROUND: Optimal resuscitation measures and outcome predictors in cases of burns are not studied in pediatric population, though it accounts for one of the leading causes of non-fatal injuries in the pediatric age group. OBJECTIVE: We describe the clinical profile and outcome predictors in children admitted with burns. MATERIALS AND METHODS: This retrospective cohort study included all children between 1 month and 18 years admitted to pediatric intensive care unit (PICU) with burns from January 2015 to December 2020...
December 2023: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38011018/prediction-of-attributable-mortality-in-pediatric-patients-with-cancer-admitted-to-the-intensive-care-unit-for-suspected-infection-a-comprehensive-evaluation-of-risk-scores
#5
JOURNAL ARTICLE
Zachary Rubnitz, Yilun Sun, Asya Agulnik, Pamela Merritt, Kim Allison, Jose Ferrolino, Ronald Dallas, Li Tang, Joshua Wolf
OBJECTIVE: To evaluate the performance of existing sepsis scores for prediction of adverse outcomes in children with cancer admitted to the ICU with suspected sepsis. DESIGN: Retrospective chart review using data available at 1, 6, 12, and 24 h after ICU admission to calculate the Pediatric Risk of Mortality 3 (PRISM-3), Pediatric Sequential Organ Failure Assessment (pSOFA), Paediatric Logistic Organ Dysfunction 2 (PELOD-2), and Quick Pediatric Sequential Organ Failure Assessment (qSOFA) scores...
November 27, 2023: Cancer Medicine
https://read.qxmd.com/read/37981801/a-need-for-a-novel-survival-risk-scoring-system-for-intensive-care-admissions-due-to-sepsis-in-pediatric-hematology-oncology-patients
#6
JOURNAL ARTICLE
Talya Wittmann Dayagi, Ronit Nirel, Galia Avrahami, Shira Amar, Sarah Elitzur, Salvador Fisher, Gil Gilead, Oded Gilad, Tracie Goldberg, Shai Izraeli, Gili Kadmon, Eytan Kaplan, Aviva Krauss, Orli Michaeli, Jerry Stein, Orna Steinberg-Shemer, Hannah Tamary, Osnat Tausky, Helen Toledano, Avichai Weissbach, Joanne Yacobovich, Asaf D Yanir, Jessica Zon, Elhanan Nahum, Shlomit Barzilai-Birenboim
Background: Children with hemato-oncological diseases or following stem cell transplantation (SCT) are at high risk for life-threatening infections; sepsis in this population constitutes a substantial proportion of pediatric intensive care unit (PICU) admissions. The current pediatric prognostic scoring tools to evaluate illness severity and mortality risk are designed for the general pediatric population and may not be adequate for this vulnerable subpopulation. Methods: Retrospective analysis was performed on all PICU admissions for sepsis in children with hemato-oncological diseases or post-SCT, in a single tertiary pediatric hospital between 2008 and 2021 ( n  = 233)...
November 19, 2023: Journal of Intensive Care Medicine
https://read.qxmd.com/read/37966344/pediatric-profound-dengue-shock-syndrome-and-use-of-point-of-care-ultrasound-during-mechanical-ventilation-to-guide-treatment-single-center-retrospective-study-2013-2021
#7
JOURNAL ARTICLE
Luan Thanh Vo, Dat Tat Nguyen, Thinh Ngoc Tran, Hang Hoang-Thanh Tran, Trang Thi-Hoai Đoan, Tram Ngoc Pham, Thanh Thi-Hoai Mai, Quynh Xuan-Thuy Nguyen, Thuan Khac Nguyen, Thuong Thi-Kim Nguyen, Sakib Burza, Thanh Tat Nguyen
OBJECTIVES: Profound dengue shock syndrome (DSS) complicated by severe respiratory failure necessitating mechanical ventilation (MV) accounts for high case fatality rates among PICU-admitted patients. A major challenge to management is the assessment of intravascular volume, which can be hampered by severe plasma leakage and the use of MV. DESIGN: Retrospective cohort, from 2013 to 2021. PATIENTS: Sixty-seven children with profound DSS supported by MV, some of whom underwent bedside point-of-care ultrasound (POCUS) for assessment and monitoring of hemodynamics and fluid administration...
November 15, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/37878412/organ-dysfunction-in-children-with-blood-culture-proven-sepsis-comparative-performance-of-four-scores-in-a-national-cohort-study
#8
JOURNAL ARTICLE
Luregn J Schlapbach, Sabrina Goertz, Niels Hagenbuch, Blandine Aubert, Sebastien Papis, Eric Giannoni, Klara M Posfay-Barbe, Martin Stocker, Ulrich Heininger, Sara Bernhard-Stirnemann, Anita Niederer-Loher, Christian R Kahlert, Giancarlo Natalucci, Christa Relly, Thomas Riedel, Christoph Aebi, Christoph Berger, Philipp K A Agyeman
OBJECTIVES: Previous studies applying Sepsis-3 criteria to children were based on retrospective analyses of PICU cohorts. We aimed to compare organ dysfunction criteria in children with blood culture-proven sepsis, including emergency department, PICU, and ward patients, and to assess relevance of organ dysfunctions for mortality prediction. DESIGN: We have carried out a nonprespecified, secondary analysis of a prospective dataset collected from September 2011 to December 2015...
March 1, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/37845523/association-of-delayed-adequate-antimicrobial-treatment-and-organ-dysfunction-in-pediatric-bloodstream-infections
#9
JOURNAL ARTICLE
Sandra Pong, Robert A Fowler, Patricia Fontela, Elaine Gilfoyle, James S Hutchison, Philippe Jouvet, Nicholas Mitsakakis, Srinivas Murthy, Jeffrey M Pernica, Asgar H Rishu, Michelle Science, Winnie Seto, Nick Daneman
BACKGROUND: Bloodstream infections (BSIs) are associated with significant mortality and morbidity, including multiple organ dysfunction. We explored if delayed adequate antimicrobial treatment for children with BSIs is associated with change in organ dysfunction as measured by PELOD-2 scores. METHODS: We conducted a multicenter, retrospective cohort study of critically ill children <18 years old with BSIs. The primary outcome was change in PELOD-2 score between days 1 (index blood culture) and 5...
October 16, 2023: Pediatric Research
https://read.qxmd.com/read/37805604/accuracy-of-pancreatic-stone-protein-for-diagnosis-of-sepsis-in-children-admitted-to-pediatric-intensive-care-or-high-dependency-care-a-pilot-study
#10
JOURNAL ARTICLE
Gabriella Bottari, Mariangela Caruso, Emanuel Paionni, Maia De Luca, Lorenza Romani, Mara Pisani, Annalisa Grandin, Livia Gargiullo, Giorgio Zampini, Chiara Gagliardi, Danilo Alunni Fegatelli, Annarita Vestri, Laura Lancella, Ottavia Porzio, Andrea Onetti Muda, Alberto Villani, Marta Ciofi Degli Atti, Massimiliano Raponi, Corrado Cecchetti
BACKGROUND: Pancreatic Stone Protein (PSP) is one of the most promising diagnostic and prognostic markers. The aim of the study was to assess the accuracy of PSP, compared to C-Reactive Protein (CRP), and Procalcitonin (PCT) for sepsis diagnosis in pediatric patients. Furthermore, we explored the correlation of PSP levels with sepsis severity and organ failure measured with PELOD-2 score. METHODS: Forty pediatric patients were enrolled following admission to pediatric intensive care, high dependency care or pediatric ward...
October 7, 2023: Italian Journal of Pediatrics
https://read.qxmd.com/read/37780052/impact-of-cytosorb-and-ckrt-on-hemodynamics-in-pediatric-patients-with-septic-shock-the-pedcyto-study
#11
JOURNAL ARTICLE
Gabriella Bottari, Isabella Guzzo, Andrea Cappoli, Raffaella Labbadia, Salvatore Perdichizzi, Carmela Serpe, Jacques Creteur, Corrado Cecchetti, Fabio Silvio Taccone
BACKGROUND: There is a lack of data to support the use of hemoadsorption in pediatric septic shock. The aim of our study was to assess the effectiveness and safety of CytoSorb therapy in this setting. METHODS: Phase II interventional single arm pilot study in which 17 consecutive children admitted with septic shock who required continuous kidney replacement therapy (CKRT) and weighed ≥10 kg were included. A CytoSorb (CytoSorbents Inc, New Jersey, USA) hemoadsorption cartridge was added to the CKRT every 24 h for a maximum of 96 h...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37751042/role-of-nuclear-factor-kappa-b-activation-and-inflammatory-biomarkers-in-critically-ill-children
#12
JOURNAL ARTICLE
Akula Sai Sneha Reddy, Swathi Sunil Rao, Vijaya D Shenoy, Shilpa Shetty
Mortality prediction is important for cautious monitoring and optimal management of critically ill children. The serum cytokine levels are elevated early in critical illness before the physiological parameters are deranged. This cross-sectional descriptive study included the critically ill children admitted in intensive care unit. Serial serum levels of IL-6, NF-κB and PELOD 2 scoring were measured and compared in 45 children (40 survivors, 5 non-survivors). The median IL-6 levels at 24 h and 72 h were significantly high in non-survivors when compared to survivors [median (IQR) = 1122 (1305) pg/ml vs...
September 26, 2023: Indian Journal of Pediatrics
https://read.qxmd.com/read/37628332/comparison-of-three-different-multiple-organ-dysfunction-scores-for-predicting-mortality-after-neonatal-cardiac-surgery
#13
JOURNAL ARTICLE
Handan Bezirganoglu, Nilufer Okur, Fatih Ozdemir, Ozlem Gul, Bedri Aldudak
Infants who undergo cardiac surgery frequently have complications that may advance to multiple organ failure and result in mortality. This study aims to compare three different multiple organ dysfunction scoring systems: the Neonatal Multiple Organ Dysfunction (NEOMOD) score, the modified NEOMOD score, and the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score in predicting postoperative 30-day mortality in neonates undergoing cardiac surgery. This retrospective cohort study was conducted between January 2019 and February 2021 in a single unit on neonates operated on due to congenital heart disease in the first 28 days of life...
August 1, 2023: Children
https://read.qxmd.com/read/37565020/troponin-i-as-an-independent-biomarker-of-outcome-in-children-with-systemic-inflammatory-response
#14
JOURNAL ARTICLE
Heitor P Leite, Rodrigo Medina, Emilio L Junior, Tulio Konstantyner
Cardiac troponin-I (cTnI) is a biomarker of myocardial injury with implications for clinical outcomes. May other contributing factors that could affect outcomes have not been uniformly considered in pediatric studies. We hypothesized that there is an association between admission serum cTnI and outcomes in critically ill children taking into account the magnitude of the acute systemic inflammatory response syndrome (SIRS), serum lactate concentrations, and nutritional status. Second, we tested for potential factors associated with elevated serum cTnI...
September 2023: Journal of Pediatric Intensive Care
https://read.qxmd.com/read/37523581/cytomegalovirus-active-infection-in-critically-ill-children
#15
JOURNAL ARTICLE
Sarah Cazella Schwab, Aparecida Yulie Yamamoto, Davi Casale Aragon, Ana Paula de Carvalho Panzeri Carlotti
OBJECTIVE: To describe the epidemiology, clinical characteristics and outcomes of children with cytomegalovirus (CMV) active infection in the pediatric intensive care unit (PICU) and to investigate risk factors for mortality. METHODS: This was a retrospective cohort study of patients who had CMV DNA detected in blood samples and/or tracheal aspirates by polymerase chain reaction (PCR) during stay at 2 PICUs of a university hospital. Suspected cases without etiological confirmation and patients with laboratory-confirmed CMV infection before PICU admission were excluded...
October 1, 2023: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/37398718/the-various-scoring-systems-in-pediatric-intensive-care-units-a-prospective-observational-study
#16
JOURNAL ARTICLE
Jyotsna, Rakesh Kumar, Shambhavi Sharan, Sunil Kishore, Jayant Prakash
BACKGROUND: The discrimination power of the pediatric risk of mortality (PRISM), pediatric index of mortality (PIM), sequential organ failure assessment (SOFA), and pediatric logistic organ dysfunction (PELOD) may not always be true for countries such as India due to differences in factors from those nations where these scoring systems were validated. Therefore, this study was undertaken to determine and compare severity, course of illness, and outcomes in critically ill children admitted to the pediatric intensive care unit (PICU) using different scoring systems such as PRISM 4, PIM 3, PELOD 2, and the pediatric sequential organ failure assessment (pSOFA ) score, and to analyze the clinical spectrum and demographic profile of children admitted to the PICU...
May 2023: Curēus
https://read.qxmd.com/read/37256281/sepsis-prognostic-scores-accuracy-in-predicting-adverse-outcomes-in-children-with-sepsis-admitted-to-the-pediatric-intensive-care-unit-from-the-emergency-department-a-10-year-single-center-experience
#17
JOURNAL ARTICLE
Luca Marchetto, Rosanna Comoretto, Dario Gregori, Liviana Da Dalt, Angela Amigoni, Marco Daverio
OBJECTIVE: To compare the performance of several prognostic scores calculated in the first 24 hours of admission (day 1) in predicting mortality and morbidity among critically ill children with sepsis presenting to the pediatric emergency department (PED) and then admitted to the pediatric intensive care unit (PICU). METHODS: Single-center, retrospective cohort study in children with a diagnosis of sepsis visiting the PED and then admitted to the PICU from January 1, 2010 to December 31, 2019...
June 1, 2023: Pediatric Emergency Care
https://read.qxmd.com/read/37255352/noninvasive-ventilation-for-pediatric-acute-respiratory-distress-syndrome-experience-from-the-2016-2017-pediatric-acute-respiratory-distress-syndrome-incidence-and-epidemiology-prospective-cohort-study
#18
JOURNAL ARTICLE
Guillaume Emeriaud, Marti Pons-Òdena, Anoopindar K Bhalla, Steven L Shein, Elizabeth Y Killien, Vicent Modesto I Alapont, Courtney Rowan, Florent Baudin, John C Lin, Gabrielle Grégoire, Natalie Napolitano, Juan Mayordomo-Colunga, Franco Diaz, Pablo Cruces, Alberto Medina, Lincoln Smith, Robinder G Khemani
OBJECTIVES: The worldwide practice and impact of noninvasive ventilation (NIV) in pediatric acute respiratory distress syndrome (PARDS) is unknown. We sought to describe NIV use and associated clinical outcomes in PARDS. DESIGN: Planned ancillary study to the 2016/2017 prospective Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology study. SETTING: One hundred five international PICUs. PATIENTS: Patients with newly diagnosed PARDS admitted during 10 study weeks...
September 1, 2023: Pediatric Critical Care Medicine
https://read.qxmd.com/read/37231783/the-role-of-blood-purification-by-ha330-as-adjunctive-treatment-in-children-with-septic-shock
#19
JOURNAL ARTICLE
Tatiya Siripanadorn, Rujipat Samransamruajkit
INTRODUCTION: Despite advances in supportive care for critically ill patients, sepsis remains an important cause of death worldwide in the PICU. One of the hallmarks of sepsis is hyperinflammation due to the excessive release of inflammatory mediators. Recently, new therapeutic approaches, such as immune modulation and blood purification, have been tried to improve outcomes in patients with septic shock. METHODS: This study is a prospective observational study composed of children with septic shock and the PELOD-2 score ≥10 or the PRISM-3 score ≥15...
May 25, 2023: Blood Purification
https://read.qxmd.com/read/37185949/predicting-functional-and-quality-of-life-outcomes-following-pediatric-sepsis-performance-of-prism-iii-and-pelod-2
#20
JOURNAL ARTICLE
Elizabeth Y Killien, R Scott Watson, Russell K Banks, Ron W Reeder, Kathleen L Meert, Jerry J Zimmerman
BACKGROUND: Illness severity scores predict mortality following pediatric critical illness. Given declining PICU mortality, we assessed the ability of the Pediatric Risk of Mortality-III (PRISM) and Pediatric Logistic Organ Dysfunction-2 (PELOD) scores to predict morbidity outcomes. METHODS: Among 359 survivors <18 years in the Life After Pediatric Sepsis Evaluation multicenter prospective cohort study, we assessed functional morbidity at hospital discharge (Functional Status Scale increase ≥3 points from baseline) and health-related quality of life (HRQL; Pediatric Quality of Life Inventory or Functional Status II-R) deterioration >25% from baseline at 1, 3, 6, and 12 months post-admission...
April 26, 2023: Pediatric Research
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