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https://www.readbyqxmd.com/read/27735800/the-relation-between-mean-platelet-volume-and-mortality-in-critical-pediatric-patients
#1
Seher Erdoğan, Arzu Oto, Mehmet Boşnak
Mean platelet volume (MPV) is a simple and economical test that is easy to interpret and is routinely measured with automatic cell counters. It indicates platelet volume and platelet function and activation. Variations in platelet volume may occur more as a result of varying differentiation of megakaryocytes in association with production agents in bone marrow rather than of ageing of platelets in circulation. The purpose of this study was to evaluate the relation between mortality and changes in MPV values in patients hospitalized in the pediatric intensive care unit...
November 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27714707/performance-of-the-pediatric-logistic-organ-dysfunction-2-score-in-critically-ill-children-requiring-plasma-transfusions
#2
Oliver Karam, Pierre Demaret, Alain Duhamel, Alison Shefler, Philip C Spinella, Simon J Stanworth, Marisa Tucci, Stéphane Leteurtre
BACKGROUND: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27449158/-multiple-organ-failure-after-spontaneous-return-of-circulation-in-cardiac-arrest-in-children
#3
Tania Carbayo, Alba de la Mata, Marina Sánchez, Jesús López-Herce, Jimena Del Castillo, Angel Carrillo
OBJECTIVE: To assess the frequency of the multiple organ failure and the prognostic value of multiple organ failure scores in children who have recovered from an in-hospital cardiac arrest. PATIENTS AND METHODS: A single centre, observational, and retrospective study was conducted on children between 1 month and 16 years old who suffered an in-hospital cardiac arrest and achieved return of spontaneous circulation (ROSC). In the first 24-48hours and between the fifth and the seventh day after ROSC, a record was made of the scores on paediatric severity (PRISM and PIM II) and multiple organ failure scales (PELOD and P-MODS), along with the clinical and analytical data, and including monitoring and treatment, mortality and cause of death...
July 20, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27399008/fluid-balance-and-length-of-mechanical-ventilation-in-children-admitted-to-a-single-pediatric-intensive-care-unit
#4
Solange Vidal, Augusto Pérez, Pablo Eulmesekian
INTRODUCTION: Associations between cumulative fluid balance and a prolonged duration of assisted mechanical ventilation have been described in adults. The aim of this study was to evaluate whether fluid balance in the first 48 hours of assisted mechanical ventilation initiation was associated with a prolonged duration of this process among children in the Pediatric Intensive Care Unit (PICU). METHODS: Retrospective cohort of patients in the PICU o, Hospital Italiano de Buenos Aires, between 1/1/2010 and 6/30/2012...
August 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27381433/-vitamin-d-deficiency-in-children-admitted-to-the-paediatric-intensive-care-unit
#5
Raúl Bustos B, Iván Rodríguez-Nuñez, Rubén Peña Zavala, Gonzalo Soto Germani
INTRODUCTION: Vitamin D is essential for bone health, as well as for cardiovascular and immune function. In critically ill adults vitamin D deficiency (VDD) is common, and is associated with sepsis and higher critical illness severity. OBJECTIVES: To establish the prevalence of VDD and its association with clinically relevant outcomes in children admitted to a Paediatric Intensive Care Unit (PICU) in Concepcion, Chile. PATIENTS AND METHOD: Prospective observational cohort study in 90 consecutive children admitted to the PICU in a university general hospital...
July 2, 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27272692/predictors-of-early-extubation-after-pediatric-cardiac-surgery-a-single-center-prospective-observational-study
#6
Çağlar Ödek, Tanıl Kendirli, Tayfun Uçar, Ayhan Yaman, Ercan Tutar, Zeynep Eyileten, Mehmet Taşar, Mehmet Ramoğlu, Can Ateş, Adnan Uysalel, Erdal İnce, Semra Atalay
This prospective, observational, single-center study aimed to determine the perioperative predictors of early extubation (<24 h after cardiac surgery) in a cohort of children undergoing cardiac surgery. Children aged between 1 month and 18 years who were consecutively admitted to pediatric intensive care unit after cardiac surgery for congenital heart disease between January 2012 and June 2014. Ninety-nine patients were qualified for inclusion during the study period. The median duration of mechanical ventilation was 20 h (range 1-480), and 64 patients were extubated within 24 h...
October 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27100422/decreased-adamts-13-activity-is-associated-with-disease-severity-and-outcome-in-pediatric-severe-sepsis
#7
Jainn-Jim Lin, Oi-Wa Chan, Hsiang-Ju Hsiao, Yu Wang, Shao-Hsuan Hsia, Cheng-Hsun Chiu
Decreased ADAMTS 13 activity has been reported in severe sepsis and in sepsis-induced disseminated intravascular coagulation. This study aimed to investigate the role of ADAMTS 13 in different pediatric sepsis syndromes and evaluate its relationship with disease severity and outcome. We prospectively collected cases of sepsis treated in a pediatric intensive care unit, between July 2012 and June 2014 in Chang Gung Children's Hospital in Taoyuan, Taiwan. Clinical characteristics and ADAMTS-13 activity were analyzed...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27089280/evaluation-of-new-diagnostic-biomarkers-in-pediatric-sepsis-matrix-metalloproteinase-9-tissue-inhibitor-of-metalloproteinase-1-mid-regional-pro-atrial-natriuretic-peptide-and-adipocyte-fatty-acid-binding-protein
#8
COMPARATIVE STUDY
Mashael F Alqahtani, Craig M Smith, Scott L Weiss, Susan Dawson, Hantamalala Ralay Ranaivo, Mark S Wainwright
Elevated plasma concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), mid-regional pro-atrial natriuretic peptide (mrProANP), and adipocyte fatty-acid-binding proteins (A-FaBPs) have been investigated as biomarkers for sepsis or detection of acute neurological injuries in adults, but not children. We carried out a single-center, prospective observational study to determine if these measures could serve as biomarkers to identify children with sepsis. A secondary aim was to determine if these biomarkers could identify children with neurologic complications of sepsis...
2016: PloS One
https://www.readbyqxmd.com/read/26953897/to-explore-the-characteristics-of-fatality-in-children-poisoned-by-paraquat-with-analysis-of-146-cases
#9
YingYing Duan, Zheng Wang
PURPOSE: The incidence of paraquat (PQ) poisoning in China is increasing, so it is important to identify the characteristics of fatalities in children with acute PQ poisoning in order to prevent and treat future cases. METHODS: A prospective study that enrolled 146 children with PQ poisoning was performed. A novel evaluation system called the score of lethal factors for PQ poisoning (SLFPP) was established, including 1 contributing factor and 4 weakening factors...
February 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/26796541/inflammation-and-organ-failure-severely-affect-midazolam-clearance-in-critically-ill-children
#10
Nienke J Vet, Janneke M Brussee, Matthijs de Hoog, Miriam G Mooij, Carin W M Verlaat, Isabel S Jerchel, Ron H N van Schaik, Birgit C P Koch, Dick Tibboel, Catherijne A J Knibbe, Saskia N de Wildt
RATIONALE: Various in vitro, animal, and limited human adult studies suggest a profound inhibitory effect of inflammation and disease on cytochrome P-450 3A (CYP3A)-mediated drug metabolism. Studies showing this relationship in critically ill patients are lacking, whereas clearance of many CYP3A drug substrates may be decreased, potentially leading to toxicity. OBJECTIVES: To prospectively study the relationship between inflammation, organ failure, and midazolam clearance as a validated marker of CYP3A-mediated drug metabolism in critically ill children...
July 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26745966/vitamin-d-deficiency-and-length-of-pediatric-intensive-care-unit-stay-a-prospective-observational-study
#11
Jhuma Sankar, Wonashi Lotha, Javed Ismail, C Anubhuti, Rameshwar S Meena, M Jeeva Sankar
BACKGROUND: Due to the limited data available in the pediatric population and lack of interventional studies to show that administration of vitamin D indeed improves clinical outcomes, opinion is still divided as to whether it is just an innocent bystander or a marker of severe disease. Our objective was therefore to estimate the prevalence of vitamin D deficiency in children admitted to intensive care unit (ICU) and to examine its association with duration of ICU stay and other key clinical outcomes...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/26744626/red-cell-transfusions-as-an-independent-risk-for-mortality-in-critically-ill-children
#12
Surender Rajasekaran, Eric Kort, Richard Hackbarth, Alan T Davis, Dominic Sanfilippo, Robert Fitzgerald, Sandra Zuiderveen, Akunne N Ndika, Hilary Beauchamp, Anthony Olivero, Nabil Hassan
BACKGROUND: Severity of illness is an important consideration in making the decision to transfuse as it is the sicker patient that often needs a red cell transfusion. Red blood cell (RBC) transfusions could potentially have direct effects and interact with presenting illness by contributing to pathologies such as multi-organ dysfunction and acute lung injury thus exerting a considerable impact on overall morbidity and mortality. In this study, we examine if transfusion is an independent predictor of mortality, or if outcomes are merely a result of the initial severity as predicted by Pediatric Risk of Mortality (PRISM) III, Pediatric Index of Mortality (PIM2), and day 1 Pediatric Logistic Organ Dysfunction (PELOD) scores...
2016: Journal of Intensive Care
https://www.readbyqxmd.com/read/26657169/prognostic-markers-among-egyptian-children-with-sepsis-in-the-intensive-care-units-cairo-university-hospitals
#13
S K Ibrahiem, Y S Galal, M R L Youssef, A S Sedrak, E M El Khateeb, N D Abdel-Hameed
BACKGROUND: Early identification of septic patients at risk of mortality is important in their prognosis. OBJECTIVE: Identification of septic patients at risk of mortality in Pediatric Intensive Care Units (PICUs) at Cairo University Hospitals, through measuring the levels of certain immunological parameters. METHODS: A hospital-based prospective cohort study was conducted in two PICUs at Cairo University Hospitals; all patients with diagnosis of severe sepsis or septic shock on admission were included...
January 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/26411864/resuscitation-bundle-in-pediatric-shock-decreases-acute-kidney-injury-and-improves-outcomes
#14
Ayse Akcan Arikan, Eric A Williams, Jeanine M Graf, Curtis E Kennedy, Binita Patel, Andrea T Cruz
OBJECTIVE: To investigate the impact of an early emergency department (ED) protocol-driven resuscitation (septic shock protocol [SSP]) on the incidence of acute kidney injury (AKI). STUDY DESIGN: This was a retrospective pediatric cohort with clinical sepsis admitted to the pediatric intensive care unit (PICU) from the ED before (2009, PRE) and after (2010, POST) implementation of the SSP. AKI was defined by pRIFLE (pediatric version of the Risk of renal dysfunction; Injury to kidney; Failure of kidney function; Loss of kidney function, End-stage renal disease creatinine criteria)...
December 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/26369662/daily-estimation-of-the-severity-of-organ-dysfunctions-in-critically-ill-children-by-using-the-pelod-2-score
#15
Stéphane Leteurtre, Alain Duhamel, Valérie Deken, Jacques Lacroix, Francis Leclerc
INTRODUCTION: Daily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using the set of seven days proposed with the previous version of the score. METHODS: In all consecutive patients admitted to nine pediatric intensive care units (PICUs) we prospectively measured the dPELOD-2 score at day 1, 2, 5, 8, 12, 16, and 18. PICU mortality was used as the outcome dependent variable...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26199699/procalcitonin-biomarker-kinetics-to-predict-multiorgan-dysfunction-syndrome-in-children-with-sepsis-and-systemic-inflammatory-response-syndrome
#16
Jiri Zurek, Martin Vavrina
BACKGROUND: Procalcitonin (PCT) kinetics is a good prognosis marker in infectious diseases, but few studies of children sepsis have been performed. OBJECTIVES: The aim of our study was to examine kinetics of procalcitonin, to evaluate its relationship with severity and to analyze its usefulness in the prediction of multiorgan dysfunction syndrome (MODS). PATIENTS AND METHODS: Prospective observational study in an 8-bed pediatric intensive care unit of a university hospital...
February 2015: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/25875250/performance-of-prism-iii-and-pelod-2-scores-in-a-pediatric-intensive-care-unit
#17
Jean-Pierre Gonçalves, Milton Severo, Carla Rocha, Joana Jardim, Teresa Mota, Augusto Ribeiro
UNLABELLED: The study aims were to compare two models (The Pediatric Risk of Mortality III (PRISM III) and Pediatric Logistic Organ Dysfunction (PELOD-2)) for prediction of mortality in a pediatric intensive care unit (PICU) and recalibrate PELOD-2 in a Portuguese population. To achieve the previous goal, a prospective cohort study to evaluate score performance (standardized mortality ratio, discrimination, and calibration) for both models was performed. A total of 556 patients consecutively admitted to our PICU between January 2011 and December 2012 were included in the analysis...
October 2015: European Journal of Pediatrics
https://www.readbyqxmd.com/read/25703785/patterns-of-multiorgan-dysfunction-after-pediatric-drowning
#18
Haifa Mtaweh, Patrick M Kochanek, Joseph A Carcillo, Michael J Bell, Ericka L Fink
AIMS: To evaluate patterns of multiorgan dysfunction and neurologic outcome in children with respiratory and cardiac arrest after drowning. METHODS: Single center retrospective chart review of children aged 0-21 years admitted between January 2001 and January 2012 to the pediatric intensive care unit at Children's Hospital of Pittsburgh with a diagnosis of drowning/submersion/immersion. Organ dysfunction scores were calculated for first 24h of admission as defined by the Pediatric Logistic Organ Dysfunction Score-1 (PELOD-1) and Pediatric Multiple Organ Dysfunction Score (P-MODS)...
May 2015: Resuscitation
https://www.readbyqxmd.com/read/25500971/plasma-glutamine-deficiency-is-associated-with-multiple-organ-failure-in-critically-ill-children
#19
Leif Ekmark, Olav Rooyackers, Jan Wernerman, Urban Fläring
A low plasma glutamine concentration (<420 µmol/L) is an independent risk factor for mortality in critically ill adult patients. Glutamine metabolism in children is less well characterized. However, pediatric ICU (PICU) mortality is low and, therefore, mortality is difficult to use as an endpoint. Here we evaluated if plasma glutamine concentration at admission to the PICU, relates to the development of multiple organ failure, using pediatric logistic organ dysfunction score (PELOD)-score. In this observational study, consecutive critically ill children (n = 149) admitted to the PICU of a tertiary university hospital as well as a reference group of healthy children (n = 60) were included...
March 2015: Amino Acids
https://www.readbyqxmd.com/read/24824802/the-prevalence-of-vitamin-d-deficiency-and-its-relationship-with-disease-severity-in-an-urban-pediatric-critical-care-unit
#20
M Ayulo, Ch Katyal, Ch Agarwal, T Sweberg, D Rastogi, M Markowitz, H M Ushay
OBJECTIVE: To evaluate the prevalence of vitamin D deficiency among patients admitted to a Pediatric Critical Care Unit (PCCU) in an urban children's hospital, and to assess if there is a correlation between vitamin D level and disease severity. PATIENTS AND METHODS: Patients (216) between the ages of 1-21 years admitted to the PCCU in a children's hospital, excluding those readmitted with a previous vitamin D level, were enrolled. Serum 25-OH vitamin D levels were measured in all patients within 24 h of admission to the PCCU...
April 2014: Endocrine Regulations
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