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https://www.readbyqxmd.com/read/29684854/the-role-of-her2-nrf2-axis-in-induction-of-oxaliplatin-resistance-in-colon-cancer-cells
#1
Abbas Pirpour Tazehkand, Maryam Akbarzadeh, Kobra Velaie, Mohammad Reza Sadeghi, Nasser Samadi
Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role in promoting chemoresistance by regulation of antioxidants and detoxification enzymes. Her2 is a member of tyrosine kinase receptor family with a key function in resistance of cancer cells to chemotherapeutics. The aim of this study was to investigate the possible cross talk between Nrf2 and Her2 mediated signaling pathways in development of oxaliplatin resistance in colon cancer cells. We first generated oxaliplatin-resistant LS174T and SW480 colon cancer cells with different Her2 expression levels by employing IC50 concentrations followed by a resting period...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684829/the-effect-of-a-training-programme-on-school-nurses-knowledge-attitudes-and-depression-recognition-skills-the-quest-cluster-randomised-controlled-trial
#2
Mark Haddad, Vanessa Pinfold, Tamsin Ford, Brendan Walsh, Andre Tylee
BACKGROUND: Mental health problems in children and young people are a vital public health issue. Only 25% of British school children with diagnosed mental health problems have specialist mental health services contact; front-line staff such as school nurses play a vital role in identifying and managing these problems, and accessing additional services for children, but there appears limited specific training and support for this aspect of their role. OBJECTIVES: To evaluate the effectiveness of a bespoke short training programme, which incorporated interactive and didactic teaching with printed and electronic resources...
April 5, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29684825/exposure-to-polybrominated-diphenyl-ethers-and-phthalates-in-healthy-men-living-in-the-greater-montreal-area-a-study-of-hormonal-balance-and-semen-quality
#3
Océane Albert, Jonathan Y Huang, Katarina Aleksa, Barbara F Hales, Cynthia G Goodyer, Bernard Robaire, Jonathan Chevrier, Peter Chan
Studies investigating the associations between exposure of young men to polybrominated diphenyl ethers (PBDEs) or phthalates and hormone levels or semen quality have produced inconsistent results. Our goal was to investigate the association of exposure to PBDEs or phthalate metabolites with changes in markers of thyroid (TSH, free T3 and free T4) and reproductive function (sperm concentrations, motility, and quality; serum LH and testosterone) in 153 healthy young men from the greater Montreal area. Using covariate-adjusted models, we found that each 10-fold increase in BDE-47 was associated with lower TSH levels (-17...
April 20, 2018: Environment International
https://www.readbyqxmd.com/read/29684748/silk-fibroin-as-a-platform-for-dual-sensing-of-vitamin-b-12-using-photoluminescence-and-electrical-techniques
#4
Sudesna Chakravarty, Bedanta Gogoi, Biman B Mandal, Nandana Bhardwaj, Neelotpal Sen Sarma
The amalgamation of natural origin materials and technologies for label-free and real time detection is pertinent in analytical field. In this study, Bombyx mori silk fibroin protein (BMSF) has been utilized for the dual sensing of vitamin B12 via fluorescence and electrical impedance techniques. The processing of BMSF is done to generate an aqueous solution of BMSF along with the development of micro patterned thin films via soft lithography technique. The BMSF aqueous solution exhibit auto fluorescence property and thereby utilized for label free detection of vitamin B12 with an estimated limit of detection (LOD) of about 0...
March 28, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29684738/characterization-and-flux-assessment-of-airborne-phthalates-released-from-polyvinyl-chloride-consumer-goods
#5
Sang-Hee Jo, Min-Hee Lee, Ki-Hyun Kim, Pawan Kumar
The concentrations and fluxes of airborne phthalates were measured from five types of polyvinyl chloride (PVC) consumer products (vinyl flooring, wallcovering, child's toy, yoga mat, and edge protector) using a small chamber (impinger) system. Airborne phthalates released from each of those PVC samples were collected using sorbent (Tenax TA) tubes at three temperature control intervals (0, 3, and 6 h) under varying temperature conditions (25, 40, and 90 °C). A total of 11 phthalate compounds were quantified in the five PVC products examined in this study...
April 20, 2018: Environmental Research
https://www.readbyqxmd.com/read/29684667/demographics-and-socioeconomic-status-as-predictors-of-weight-loss-after-laparoscopic-sleeve-gastrectomy-a-prospective-cohort-study
#6
Amani Jambhekar, Amy Maselli, Shawn Robinson, Krystyna Kabata, Piotr Gorecki
BACKGROUND: Prior studies have established that race and socioeconomic factors may influence weight loss after bariatric surgery. Few studies have focused on laparoscopic sleeve gastrectomy (LSG). The objective of this study is to determine if demographic factors may predict postoperative weight loss following LSG. METHODS: Prospectively collected data on 713 consecutive primary LSG operations performed with the same technique between February 2010 and May 2016 by a single surgeon (PG) were analyzed...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29684564/deep-npm1-sequencing-following-allogeneic-hematopoietic-cell-transplantation-improves-risk-assessment-in-adults-with-npm1-mutated-aml
#7
Yi Zhou, Megan Othus, Roland B Walter, Elihu H Estey, David Wu, Brent L Wood
Relapse is the major cause of death in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplant (HCT). Measurable residual disease (MRD) detected by multiparameter flow cytometry (MFC) before and after HCT is a strong, independent risk factor for relapse. As next generation sequencing (NGS) is increasingly applied in AML MRD detection, it remains to be determined if NGS can improve prediction of post-HCT relapse. Herein, we investigated pre-HCT MRD detected by MFC and NGS in 59 adult patients with NPM1-mutated AML in morphologic remission; 45 of the 59 had post-HCT MRD determined by MFC and NGS around day 28...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29684540/chemical-composition-antioxidant-anticholinesterase-antimicrobial-and-antibiofilm-activities-of-essential-oil-and-methanolic-extract-of-anthemis-stiparum-subsp-sabulicola-pomel-oberpr
#8
Ahmed Elkhalifa Chemsa, Amar Zellagui, Mehmet Öztürk, Ebru Erol, Ozgür Ceylan, Mehmet Emin Duru, Mesbah Lahouel
Anthemis species are traditionally used to treat infectious and inflammatory processes, among others clinical disturbances. In the current study, the chemical composition, the total phenolic and flavonoid contents, the antioxidant, anticholinesterase, antimicrobial, and antibiofilm activities of Anthemis stiparum subsp. sabulicola aerial parts methanolic extract (As-ME) and essential oil (As-EO) were investigated. The chemical composition of As-EO was established by GC-MS and GC-FID. Total phenolic and flavonoid contents of As-ME were spectrophotometrically determined...
April 20, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29684489/analysis-of-the-microrna-transcriptome-of-daphnia-pulex-during-aging
#9
Jiabao Hu, Chongyuan Lin, Mengdi Liu, Qiaoqiong Tong, Shanliang Xu, Danli Wang, Yunlong Zhao
Daphnia pulex is an important food organism that exhibits a particular mode of reproduction known as cyclical parthenogenesis (asexual) and sexual reproduction. Regulation of the aging process by microRNAs (miRNAs) is a research hotspot in miRNA studies. To investigate a possible role of miRNAs in regulating aging and senescence, we used Illumina HiSeq to sequence two miRNA libraries from 1-day-old (1d) and 25-day-old (25d) D. pulex specimens. In total, we obtained 11,218,097 clean reads and 28,569 unique miRNAs from 1d specimens and 11,819,106 clean reads and 44,709 unique miRNAs from 25d specimens...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29684414/examining-variability-in-parent-feeding-practices-within-a-low-income-racially-ethnically-diverse-and-immigrant-population-using-ecological-momentary-assessment
#10
Jerica M Berge, Allan Tate, Amanda Trofholz, Katie Loth, Michael Miner, Scott Crow, Dianne Neumark-Sztainer
BACKGROUND: Current measures of parent feeding practices are typically survey-based and assessed as static/unchanging characteristics, failing to account for fluctuations in these behaviors across time and context. The current study uses ecological momentary assessment to examine variability of, and predictors of parent feeding practices within a low-income, racially/ethnically diverse, and immigrant sample. METHODS: Children ages 5-7 years old and their parents (n = 150 dyads) from six racial/ethnic groups (n = 25 from each; Black/African American, Hispanic, Hmong, Native American, Somali, White) were recruited for this mixed-methods study through primary care clinics...
April 20, 2018: Appetite
https://www.readbyqxmd.com/read/29684341/predictors-of-outcome-in-patients-with-hematologic-malignancies-admitted-to-the-intensive-care-unit
#11
Nassar Al-Zubaidi, Emad Shehada, Khaled Alshabani, Jihane ZazaDitYafawi, Pascal Kingah, Ayman O Soubani
PURPOSE: Several studies showed conflicting results about prognosis and predictors of outcome of critically ill patients with hematological malignancies (HM). The aim of this study is to determine the hospital outcome of critically ill patients with HM and the factors predicting the outcome. METHODS AND MATERIALS: All patients with HM admitted to MICU at a tertiary academic medical center were enrolled. Clinical data upon admission and during ICU stay were collected...
April 17, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29684291/short-term-prediction-of-coronary-heart-disease-mortality-in-the-czech-republic-based-on-data-from-1968-2014
#12
Jindra Reissigová, Miroslav Zvolský
OBJECTIVES: The aim was to explore the patterns of the coronary heart disease (CHD) mortality rates over the past almost 50 years (1968-2014) in the Czech Republic, and to predict the mortality rates in 2015-2019. METHODS: The number of deaths from CHD and the population size were stratified by sex and age. The mortality rates were age-standardized to European population. Their values in 2015-2019 were estimated using the joinpoint log-linear regression, local log-linear regression and negative binomial log-linear regression, separately for males and females...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684281/superactivity-of-mof-808-towards-peptide-bond-hydrolysis
#13
Hong Giang T Ly, Guangxia Fu, Aleksandar Kondinski, Bart Bueken, Dirk De Vos, Tatjana N Parac-Vogt
MOF-808, a Zr(IV)-based metal-organic framework, has been proven to be a very effective heterogeneous catalyst for the hydrolysis of the peptide bond in a wide range of peptides and in hen egg white lysozyme protein. The kinetic experiments with a series of Gly-X dipeptides with varying nature of amino acid side chain have shown that MOF-808 exhibits selectivity depending on the size and chemical nature of the X side chain. Dipeptides with smaller or hydrophilic residues were hydrolyzed faster than those with bulky and hydrophobic residues that lack electron rich functionalities which could engage in favourable intermolecular interactions with the btc linkers...
April 23, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29684161/impact-of-heat-stress-during-the-follicular-phase-on-porcine-ovarian-steroidogenic-and-phosphatidylinositol-3-signaling
#14
M J Dickson, C L Hager, A Al-Shaibi, P Q Thomas, L H Baumgard, J W Ross, A F Keating
Environmental conditions that impede heat dissipation and increase body temperature cause heat stress (HS). The study objective was to evaluate impacts of HS on the follicular phase of the estrous cycle. Post-pubertal gilts (126.0 ± 21.6 kg) were orally administered altrenogest to synchronize estrus, and subjected to either 5 d of thermal neutral (TN; 20.3 ± 0.5°C; n = 6) or cyclical HS (25.4 - 31.9°C; n = 6) conditions during the follicular phase preceding behavioral estrus. On d 5, blood samples were obtained, gilts were euthanized, and ovaries collected...
April 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29684145/effect-of-roller-mill-configuration-on-growth-performance-of-nursery-and-finishing-pigs-and-milling-characteristics
#15
J T Gebhardt, C B Paulk, M D Tokach, J M DeRouchey, R D Goodband, J C Woodworth, J A DeJong, K F Coble, C R Stark, C K Jones, S S Dritz
Three experiments were conducted to evaluate the effects of roller mill configuration on growth performance of nursery and finishing pigs, feed preference, and feed mill throughput. The 4 experimental treatments included corn ground through a roller mill using 2, 3, 4 sets of rolls in a fine grind configuration, or 4 sets of rolls in a coarse grind configuration. The same roller mill was used for all configurations with the appropriate lower rolls completely open when using the 2 or 3 roll pair configurations...
April 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29684118/spontaneous-endometriosis-in-cynomolgus-monkeys-as-a-clinically-relevant-experimental-model
#16
A Nishimoto-Kakiuchi, S Netsu, S Okabayashi, K Taniguchi, H Tanimura, A Kato, M Suzuki, T Sankai, R Konno
STUDY QUESTION: Does spontaneous endometriosis in cynomolgus monkeys have the characteristics required of a good experimental model? SUMMARY ANSWER: Spontaneous endometriosis in cynomolgus monkeys exhibited similar clinicopathological characteristics to the human disease and was useful as an experimental model. WHAT IS KNOWN ALREADY: The prevalence of endometriosis in autopsied cynomolgus monkeys (Macaca fascicularis) in a breeding colony was reported to be 28...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29684094/quantitative-analyses-of-factors-related-to-anxiety-and-depression-in-patients-with-retinitis-pigmentosa
#17
Mayumi Sainohira, Takehiro Yamashita, Hiroto Terasaki, Shozo Sonoda, Kazunori Miyata, Yusuke Murakami, Yasuhiro Ikeda, Takeshi Morimoto, Takao Endo, Takashi Fujikado, Junko Kamo, Taiji Sakamoto
The purpose of this study is to determine the factors related to anxiety and depression in patients with retinitis pigmentosa (RP). The status of anxiety and depression was determined in RP patients with the Hospital Anxiety and Depression Scale (HADS) questionnaire which consisted of subscales for HADS-anxiety (HADS-A) and HADS-depression (HADS-D). The vision-specific quality of life (VSQOL) was assessed with the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ25). The correlations between the HADS-A or HADS-D scores and vision-related clinical parameters such as the best-corrected visual acuity (BCVA), Functional Acuity Score, Functional Field Score, Functional Vision Score, the NEI- VFQ25 subscale score were determined...
2018: PloS One
https://www.readbyqxmd.com/read/29684027/chronic-calcitriol-supplementation-improves-the-inflammatory-profiles-of-circulating-monocytes-and-the-associated-intestinal-adipose-tissue-alteration-in-a-diet-induced-steatohepatitis-rat-model
#18
Yen-Bo Su, Tzu-Hao Li, Chia-Chang Huang, Hung-Cheng Tsai, Shiang-Fen Huang, Yun-Cheng Hsieh, Ying-Ying Yang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Vitamin D deficiency and up-regulated TNFα-related signals are reported to be involved in abnormalities including intestinal hyper-permeability, bacterial translocation, systemic/portal endotoxemia, intestinal/adipose tissue/hepatic inflammation, and hepatic steatosis in nonalcoholic steatohepatitis (NASH). This study aims to explore the molecular mechanisms and effects of chronic calcitriol [1,25-(OH)2D3, hormonal form of vitamin D] on gut-adipose tissue-liver axis abnormalities using a high-fat diet (HFD)-fed rat model of NASH...
2018: PloS One
https://www.readbyqxmd.com/read/29683996/biliary-drainage-in-patients-with-failed-ercp-percutaneous-versus-eus-guided-drainage
#19
Félix I Téllez-Ávila, David Herrera-Mora, Gilberto Duarte-Medrano, Gustavo Lopez-Arce, Dayana Lindoro-Barraza, Iván Casanova, Javier Elizondo-Rivera, Miguel Ramírez-Luna, Francisco Valdovinos-Andraca
AIM: The goal of the study is to compare the efficacy and safety of bile duct drains guided by endoscopic ultrasound-guided biliary drainage (EGBD) versus percutaneous transhepatic biliary drainage (PTBD). MATERIALS AND METHODS: Retrospective comparative study. Patients with obstruction of the bile duct who underwent the EGBD or PTBD procedure and had at least 1 previous endoscopic retrograde cholangiopancreatography that failed or was inaccessible to the second duodenal portion were included...
April 21, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29683985/accommodative-behavior-of-young-eyes-wearing-multifocal-contact-lenses
#20
Basal H Altoaimi, Meznah S Almutairi, Pete S Kollbaum, Arthur Bradley
SIGNIFICANCE: The effectiveness of multifocal contact lenses (MFCLs) at slowing myopia progression may hinge on the accommodative behavior of young eyes fit with these presbyopic style lenses. Can they remove hyperopic defocus? Convergence accommodation as well as pupil size and the zonal geometry are likely to contribute to the final accommodative responses. PURPOSE: The aim of this study was to examine the accommodation behavior of young adult eyes wearing MFCLs and the effectiveness of these MFCLs at removing foveal hyperopic defocus when viewing near targets binocularly...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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