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https://www.readbyqxmd.com/read/29241196/calycosin-inhibits-the-migration-and-invasion-of-human-breast-cancer-cells-by-down-regulation-of-foxp3-expression
#1
Shuangxi Li, Yafei Wang, Chan Feng, Guoli Wu, Yu Ye, Jing Tian
BACKGROUND/AIMS: Calycosin, a phytoestrogenic compound, has recently emerged as a promising antitumor drug. It has been shown that calycosin suppresses growth and induces apoptosis of breast cancer cells. However, the effect of calycosin on migration and invasion of breast cancer cells and the underlying molecular mechanisms have not been elucidated. METHODS: Human breast cancer cells MCF-7 and T47D were treated with, or without, different doses (0, 6.25, 12.5, 25, 50, 100 or 150 μM) of calycosin, and the viability of different groups was determined by MTT assay...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241104/the-relationship-between-self-compassion-and-the-risk-for-substance-use-disorder
#2
Cynthia L Phelps, Samantha M Paniagua, Irmgard U Willcockson, Jennifer S Potter
OBJECTIVE: This study explored the relationship between substance use disorder risk and self-compassion and posits a model for how the two are related through the mitigation of suffering. METHOD: Study participants were recruited using social media to complete an online survey that included a basic socio-demographic survey and two validated instruments, the Self-Compassion Survey and the National Institute on Drug Abuse (NIDA) Alcohol Smoking and Substance Involvement Screening Test (ASSIST), which screens for substance use disorder (SUD) risk...
December 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29240976/clopidogrel-plus-aspirin-versus-aspirin-alone-for-preventing-cardiovascular-events
#3
REVIEW
Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo Donadini
BACKGROUND: Aspirin is the prophylactic antiplatelet drug of choice for people with cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional benefit for people at high risk and people with established cardiovascular disease. This is an update to a previously published review from 2011. OBJECTIVES: To review the benefit and harm of adding clopidogrel to aspirin therapy for preventing cardiovascular events in people who have coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease, or were at high risk of atherothrombotic disease, but did not have a coronary stent...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29240958/short-and-long-term-effects-of-hemodialysis-on-platelet-and-monocyte-activity-markers-of-atherosclerosis-in-patients-with-end-stage-renal-disease
#4
Urs Benck, Ksenija Stach, Susanne Jung, Bernhard K Krämer, Thorsten Kälsch, Anna-Isabelle Kälsch
BACKGROUND: In hemodialysis (HD) patients cardiovascular events represent the predominant cause of mortality. Since platelet and monocyte activity markers play an important role in cardiovascular mortality, this study assessed the influence of HD on these markers. METHODS: 41 HD patients (25 male, 16 female) were included. Blood samples were obtained before and after a single HD session at baseline and again after an elapsed period of 114  21 days (91-175 days) on maintenance hemodialysis...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240864/patient-awareness-of-local-drug-price-variation-and-the-factors-that-influence-pharmacy-choice-a-cross-sectional-survey-study
#5
Spencer D Brodsky, Olabola D Awosika, Misty G Eleryan, Monica Rengifo-Pardo, Xiangyu Kuang, Richard L Amdur, Alison Ehrlich
<p>Background: High out-of-pocket drug expenditures are increasingly common in dermatology. Patients may not be aware that prices vary among pharmacies and consequently may not shop for the lowest cost.</p> <p>Objective: To determine what factors influence pharmacy choice and the effect of providing local prescription prices on pharmacy selection. We hypothesized that patients do not "shop around" due to lack of knowledge of price variation and would choose a pharmacy based on costs if educated on price disparity...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240797/a-mucoadhesive-thermoreversible-in-situ-nasal-gel-of-geniposide-for-neurodegenerative-diseases
#6
Yingting Wang, Shulong Jiang, Hongli Wang, Haiyan Bie
Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration. The objective of this study was to develop and evaluate a mucoadhesive, thermoreversible in situ nasal gel of geniposide...
2017: PloS One
https://www.readbyqxmd.com/read/29240796/improving-the-quality-of-child-anthropometry-manual-anthropometry-in-the-body-imaging-for-nutritional-assessment-study-bina
#7
Joel Conkle, Usha Ramakrishnan, Rafael Flores-Ayala, Parminder S Suchdev, Reynaldo Martorell
Anthropometric data collected in clinics and surveys are often inaccurate and unreliable due to measurement error. The Body Imaging for Nutritional Assessment Study (BINA) evaluated the ability of 3D imaging to correctly measure stature, head circumference (HC) and arm circumference (MUAC) for children under five years of age. This paper describes the protocol for and the quality of manual anthropometric measurements in BINA, a study conducted in 2016-17 in Atlanta, USA. Quality was evaluated by examining digit preference, biological plausibility of z-scores, z-score standard deviations, and reliability...
2017: PloS One
https://www.readbyqxmd.com/read/29240786/time-trend-analysis-2009-2016-of-antimicrobial-susceptibility-in-neisseria-gonorrhoeae-isolated-in-italy-following-the-introduction-of-the-combined-antimicrobial-therapy
#8
Paola Stefanelli, Maria Fenicia Vescio, Maria Paola Landini, Ivano Dal Conte, Alberto Matteelli, Antonio Cristaudo, Marina Gaino, Marco Cusini, Anna Maria Barbui, Antonella Mencacci, Rosella De Nittis, Valeria Ghisetti, Elena Stroppiana, Anna Carannante
INTRODUCTION: Neisseria gonorrhoeae (NG) antimicrobial susceptibility trends to azithromycin, cefixime and ceftriaxone were analyzed, from 2009 to 2016, to monitor changing antimicrobial susceptibility concomitant with the change in prescribing practice in 2012 from cefixime, or ceftriaxone, to ceftriaxone plus azithromycin. Patient characteristics predictive to be infected by antibiotic resistant N. gonorrhoeae were estimated. Finally, the protocol for the treatment of gonorrhoea, in comparison with the international guidelines, was also evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29240657/inequalities-in-health-services-usage-in-a-national-health-system-scheme-the-case-of-a-southern-social-european-region
#9
Maite Morteruel, Elena Rodriguez-Alvarez, Unai Martin, Amaia Bacigalupe
BACKGROUND: Health services can reduce inequalities caused by other determinants of health or increase them due to the effect of the inverse care law-the principle that the availability of good quality care tends to vary inversely with the need for it in the population served. OBJECTIVE: The purpose of the research was to describe inequalities in the use of nursing services, medical services in primary care, specialist care, and services not fully covered by the Basque public health system in Spain...
January 2018: Nursing Research
https://www.readbyqxmd.com/read/29240642/body-mass-s-impact-on-response-to-fixed-dose-vasopressin-in-patients-with-septic-shock
#10
Heather Torbic, Gretchen L Sacha, Seth R Bauer, Simon W Lam
INTRODUCTION: The effect of patient weight and body mass index (BMI) on hemodynamic response to vasoactive medications is not fully understood. In titratable vasopressors, this effect is less likely a concern due to the ability to titrate dose to response, however, with the use of fixed-dose vasopressin, patient weight and BMI may impact response. METHODS: This was a single center, retrospective cohort of patients who received fixed-dose vasopressin for septic shock for ≥6 hours with concomitant catecholamines in the medical, surgical, or neurosciences intensive care unit (ICU) at a tertiary care center...
December 13, 2017: Shock
https://www.readbyqxmd.com/read/29240603/what-is-the-optimal-adjuvant-treatment-sequence-for-node-positive-endometrial-cancer-results-of-a-national-cancer-database-analysis
#11
Ankit Modh, Ahmed I Ghanem, Charlotte Burmeister, Rabbie K Hanna, Mohamed A Elshaikh
OBJECTIVE: The optimal sequence of administering chemotherapy (CT) and radiation treatment (RT) in women with node-positive endometrial carcinoma (EC) remains controversial. We used the National Cancer Database to evaluate overall survival (OS) in women with advanced EC receiving different sequences of adjuvant therapy. METHODS: The National Cancer Database was queried for female adults with International Federation of Gynecology and Obstetrics 2009 stage IIIC1 to IIIC2 EC diagnosed from 2004 to 2012 treated with hysterectomy and adjuvant CT and RT...
December 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29240580/prognostic-significance-of-periadnexal-extension-in-cutaneous-melanoma-and-its-implications-for-pathologic-reporting-and-staging
#12
Tristan J Dodds, Serigne Lo, Louise Jackett, Omgo Nieweg, John F Thompson, Richard A Scolyer
Tumor thickness is the strongest predictor of outcome for clinically localized melanoma. Therefore, accurate assessment is critical for appropriate staging, reliable estimation of prognosis, and management. When melanoma extends alongside skin adnexal structures more deeply than the main tumor mass (periadnexal extension), it is currently unknown whether the prognosis is more accurately reflected by the deepest point of periadnexal tumor extension or the main tumor mass. This study sought to address this question...
December 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29240293/transvenous-pacemaker-implantation-after-the-bidirectional-glenn-operation-for-patients-with-complex-congenital-disease
#13
Danielle E Harake, Kevin M Shannon, Jamil A Aboulhosn, Jeremy P Moore
INTRODUCTION: The bidirectional Glenn operation for congenital heart disease produces anatomical constraints to conventional transvenous pacemaker implantation. An iliac approach, although not previously described in this population, is potentially a preferable alternative to a thoracotomy for epicardial pacing. METHODS AND RESULTS: A single-center retrospective review was performed for all patients that underwent transvenous pacemaker implantation following the bidirectional Glenn operation with partial biventricular repair...
December 14, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29240253/outcome-following-second-allogeneic-hematopoietic-cell-transplantation-a-single-center-experience
#14
Hassan A Aljasem, Hans A Messner, Jeffrey H Lipton, Dennis Dong Hwan Kim, Auro Viswabandya, Santhosh Thyagu, Uday Deotare, Fotios V Michelis
OBJECTIVE: Second allogeneic hematopoietic cell transplantation (HCT) may be indicated following relapse or graft failure following first HCT. Our retrospective single-center study sought to investigate parameters that influence post-second allogeneic HCT survival METHOD: We investigated 92 patients that underwent second allogeneic HCT between 1980 and 2016 for relapse or graft failure following first HCT. Median age at second HCT was 41 years (range 16-68), performed for relapse in 59 patients (64%) and for graft failure in 33 patients (36%) RESULTS: On univariate analysis, 3-year OS of the entire cohort was 35% (95%CI=25-45)...
December 14, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29239964/superior-efficacy-of-lipid-emulsion-infusion-over-serum-alkalinization-in-reversing-amitriptyline-induced-cardiotoxicity-in-guinea-pig
#15
Shogo Tsujikawa, Tadashi Matsuura, Kotaro Hori, Takashi Mori, Miyuki Kuno, Kiyonobu Nishikawa
BACKGROUND: Tricyclic antidepressants (TCAs) are a major cause of fatal drug poisoning due to their cardiotoxicity. Alkalinization by sodium bicarbonate (NaHCO3) administration, the first-line therapy for TCA-induced cardiotoxicity, can occasionally yield insufficient efficacy in severe cases. Because most TCAs are highly lipophilic, lipid emulsion may be more effective than alkalinization. However, it remains to be determined whether lipid emulsion is more beneficial than alkalinization in reversing amitriptyline-induced cardiotoxicity...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239940/prolonged-duration-local-anesthesia-using-liposomal-bupivacaine-combined-with-liposomal-dexamethasone-and-dexmedetomidine
#16
Alina Y Rwei, Robert T Sherburne, David Zurakowski, Bruce Wang, Daniel S Kohane
BACKGROUND: The relatively short duration of effect of local anesthetics has been addressed by encapsulation in drug delivery systems. Codelivery with a single compound that produces an adjuvant effect on nerve block but without intrinsic local anesthetic properties can further prolong the nerve block effect. Here, we investigated whether codelivery of more than 1 encapsulated adjuvant compound can further enhance nerve blockade. METHODS: Liposomes loaded with bupivacaine (Bup), dexamethasone phosphate (DexP), or dexmedetomidine (DMED) were synthesized and its in vitro drug release profiles were determined...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29239908/vitamin-c-is-not-the-missing-link-between-cigarette-smoking-and-spinal-pain
#17
Clermont E Dionne, Danielle Laurin, Thérèse Desrosiers, Belkacem Abdous, Natalie Le Sage, Jérôme Frenette, Myrto Mondor, Sylvie Pelletier
STUDY DESIGN: A nationwide cross-sectional study. OBJECTIVES: To measure the associations between cigarette smoking (defined as serum cotinine concentration > 15 ng/ml) and the 3-month prevalence of spinal pain (neck pain, low back pain, low back pain with pain below knee, and self-reported diagnosis of arthritis/rheumatism) and related limitations, and to verify whether these associations are mediated by serum concentrations of vitamin C. SUMMARY OF BACKGROUND DATA: Cigarette smoking has been consistently associated with back pain, but this association has never been explained...
December 12, 2017: Spine
https://www.readbyqxmd.com/read/29239888/eleven-year-incident-glucose-disorders-in-treated-hiv-infection-the-st-vincent-s-hiv-and-diabetes-study
#18
Chelsea N McMahon, Kathy Petoumenos, Karl Hesse, Andrew Carr, David A Cooper, Katherine Samaras
OBJECTIVES: To determine the long-term incidence of glucose disorders in treated HIV-infection, associations with traditional and HIV-specific risk factors and whether glycemic status predicts mortality. METHODS: Observational cohort of 104 men with treated HIV-infection and without diabetes, aged 43 ± 8y at baseline, with (mean ± SD) 11 8 ± 3 5y follow-up, with ascertainment of glucose status by fasting glucose or, in a subset (n = 33), a 75 g oral glucose tolerance test by 10-12 years follow-up...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239770/lead-identification-and-optimization-of-bacterial-glutamate-racemase-inhibitors
#19
Prasanthi Malapati, Vagolu Siva Krishna, Radhika Nallangi, Nikhila Meda, Rudraraju Reshma Srilakshmi, Dharmarajan Sriram
Mycobacterium tuberculosis glutamate racemase is an essential enzyme involved in peptidoglycan synthesis and conserved in most bacteria. Small molecule inhibitors were reported on other bacterial species whereas in M. tuberculosis it wasn't explored much. In this study we have screened in house compound library using fluorescence thermal shift assay and enzyme inhibition assay, form this (1-(3-(benzo[d]thiazol-2-yl)phenyl)-3-(p-tolyl)thiourea) was identified as lead compound with IC50 19.47 ± 0.81 μM...
November 21, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29239552/the-use-of-geographic-information-system-as-a-tool-for-schistosomiasis-surveillance-in-the-province-of-davao-del-norte-the-philippines
#20
Vicente Y Belizario, John Paul Caesar R Delos Trinos, Berne Silawan, Chiqui M De Veyra, Agapito Hornido, Hansel Amoguis, Dominic Basalo, Cherry Dema-Ala, Irenn Mantilla, Rosele Layan
Schistosomiasis (SCH) in The Philippines is caused by Schistosoma japonicum and remains endemic in 28 provinces in 12 regions. Effective SCH control requires describing areas at risk where control efforts may be focused. This study aims at demonstrating the utility of geographical information system (GIS) as a tool for SCH surveillance in the province of Davao del Norte. Qualitative and quantitative data on SCH determinants, obtained from local government offices, partner agencies and institutions, were standardised, formatted and incorporated into a GIS map...
November 6, 2017: Geospatial Health
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