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https://www.readbyqxmd.com/read/27887664/translating-sickle-cell-guidelines-into-practice-for-primary-care-providers-with-project-echo
#1
Lisa M Shook, Christina B Farrell, Karen A Kalinyak, Stephen C Nelson, Brandon M Hardesty, Angeli G Rampersad, Kay L Saving, Wanda J Whitten-Shurney, Julie A Panepinto, Russell E Ware, Lori E Crosby
BACKGROUND: Approximately 100,000 persons with sickle cell disease (SCD) live in the United States, including 15,000 in the Midwest. Unfortunately, many patients experience poor health outcomes due to limited access to primary care providers (PCPs) who are prepared to deliver evidence-based SCD care. Sickle Treatment and Outcomes Research in the Midwest (STORM) is a regional network established to improve care and outcomes for individuals with SCD living in Indiana, Illinois, Michigan, Minnesota, Ohio, and Wisconsin...
2016: Medical Education Online
https://www.readbyqxmd.com/read/27835052/options-for-improving-effectiveness-of-rotavirus-vaccines-in-developing-countries
#2
Marion S Tissera, Daniel Cowley, Nada Bogdanovic-Sakran, Melanie L Hutton, Dena Lyras, Carl D Kirkwood, Jim P Buttery
Rotavirus gastroenteritis is a leading global cause of mortality and morbidity in young children due to diarrhea and dehydration. Over 85% of deaths occur in developing countries. In industrialised countries, two live oral rotavirus vaccines licensed in 2006 quickly demonstrated high effectiveness, dramatically reducing severe rotavirus gastroenteritis admissions in many settings by more than 90%. In contrast, the same vaccines reduced severe rotavirus gastroenteritis by only 30-60% in developing countries, but have been proven life-saving...
November 11, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27829445/improving-early-childhood-care-and-development-hiv-testing-treatment-and-support-and-nutrition-in-mokhotlong-lesotho-study-protocol-for-a-cluster-randomized-controlled-trial
#3
Mark Tomlinson, Sarah Skeen, Marguerite Marlow, Lucie Cluver, Peter Cooper, Lynne Murray, Shoeshoe Mofokeng, Nathene Morley, Moroesi Makhetha, Sarah Gordon, Tonya Esterhuizen, Lorraine Sherr
BACKGROUND: Since 1990, the lives of 48 million children under the age of 5 years have been saved because of increased investments in reducing child mortality. However, despite these unprecedented gains, 250 million children younger than 5 years in low- and middle-income countries (LMIC) cannot meet their developmental potential due to poverty, poor health and nutrition, and lack of necessary stimulation and care. Lesotho has high levels of poverty, HIV, and malnutrition, all of which affect child development outcomes...
November 9, 2016: Trials
https://www.readbyqxmd.com/read/27787178/talking-about-suicide-can-help-to-save-lives
#4
Sarah Fitchett
In England, one person dies every 2 hours as a result of suicide. It is the leading cause of death for young people in the UK. Every year about 1,600 children and young people aged 10 to 34 take their own lives. The charity Childline receives an average of one call every 30 minutes from British children with suicidal thoughts. That works out at 19,481 in the past year alone, more than double the number 5 years ago. And yet, we still aren't talking about it.
October 26, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27761875/saving-deaf-children-screening-for-hearing-loss-as-a-public-interest-case
#5
Sigrid Bosteels, Michel Vandenbroeck, Geert Van Hove
New-born screening programs for congenital disorders and chronic disease are expanding worldwide and children "at risk" are identified by nationwide tracking systems at the earliest possible stage. These practices are never neutral and raise important social and ethical questions. An emergent concern is that a reflexive professionalism should interrogate the ever earlier interference in children's lives. The Flemish community of Belgium was among the first to generalize the screening for hearing loss in young children and is an interesting case to study the public justification of early interventions for families with deaf children...
October 19, 2016: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/27677782/mdma-methylone-and-mdpv-drug-induced-brain-hyperthermia-and-its-modulation-by-activity-state-and-environment
#6
Eugene A Kiyatkin, Suelynn E Ren
Psychomotor stimulants are frequently used by humans to intensify the subjective experience of different types of social interactions. Since psychomotor stimulants enhance metabolism and increase body temperatures, their use under conditions of physiological activation and in warm humid environments could result in pathological hyperthermia, a life-threatening symptom of acute drug intoxication. Here, we will describe the brain hyperthermic effects of MDMA, MDPV, and methylone, three structurally related recreational drugs commonly used by young adults during raves and other forms of social gatherings...
September 28, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27588542/an-examination-of-the-effectiveness-of-child-endangerment-laws-in-preventing-child-fatalities-in-alcohol-involved-motor-vehicle-crashes
#7
Tara Kelley-Baker, Eduardo Romano
OBJECTIVE: The aim of this study was to assess the impact of U.S. child-endangerment laws on the prevalence of child passengers fatally injured in motor vehicle crashes in which the adult driver was drinking. METHOD: We used data from the 2002-2012 Fatality Analysis Reporting System. We conducted both bivariate and multivariate analyses using Heckman selection models. RESULTS: After adjusting for several cofactors, including driver demographics and blood alcohol concentration, child seat positioning, and seat belt laws, we found that passing a DUI child-endangerment law may have no impact at all on the likelihood of finding impaired drivers among those driving with children...
September 2016: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27585843/radiation-risk-of-breast-screening-in-england-with-digital-mammography
#8
Lucy M Warren, David R Dance, Kenneth C Young
OBJECTIVE: To estimate the risks and benefits of breast screening in terms of number of deaths due to radiation-induced cancers and the number of lives saved due to modern screening in the National Health Service Breast Screening Programme (NHSBSP) in England. METHODS: A radiation risk model, patient dose data and data from national screening statistics were used to estimate the number of deaths due to radiation induced breast cancers in the NHSBSP in England. Dose and dose effectiveness factors (DDREFs) equal to one and two were assumed...
September 2, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27558490/prospective-risk-for-suicidal-thoughts-and-behaviour-in-adolescents-with-onset-maintenance-or-cessation-of-direct-self-injurious-behaviour
#9
Julian Koenig, Romuald Brunner, Gloria Fischer-Waldschmidt, Peter Parzer, Paul L Plener, JiYeon Park, Camilla Wasserman, Vladimir Carli, Christina W Hoven, Marco Sarchiapone, Danuta Wasserman, Franz Resch, Michael Kaess
Direct self-injurious behaviour (D-SIB) is associated with suicidal behaviour and suicide risk. It is not known if D-SIB cessation reduces these risks. The aim of this study was to explore trajectories of D-SIB and their prospective influence on suicidal thoughts and behaviour during adolescence. Data (n = 506; 62.06 % females, 14.53 years) from the Saving and Empowering Young Lives in Europe study were analysed. D-SIB and suicidal thoughts and behaviour were assessed at baseline (T0), 1- (T1) and 2-year follow-up (T2)...
August 24, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27550978/medication-assisted-treatment-of-adolescents-with-opioid-use-disorders
#10
(no author information available yet)
Opioid use disorder is a leading cause of morbidity and mortality among US youth. Effective treatments, both medications and substance use disorder counseling, are available but underused, and access to developmentally appropriate treatment is severely restricted for adolescents and young adults. Resources to disseminate available therapies and to develop new treatments specifically for this age group are needed to save and improve lives of youth with opioid addiction.
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27538438/diarrhea-management-in-children-under-five-in-sub-saharan-africa-does-the-source-of-care-matter-a-countdown-analysis
#11
Liliana Carvajal-Vélez, Agbessi Amouzou, Jamie Perin, Abdoulaye Maïga, Hayalnesh Tarekegn, Akanni Akinyemi, Solomon Shiferaw, Mark Young, Jennifer Bryce, Holly Newby
BACKGROUND: Diarrhea remains a high burden disease, responsible for nine percent of deaths in children under five globally. We analyzed diarrhea management practices in young children and their association with the source of care. METHODS: We used Demographic and Health Survey data from 12 countries in sub-Saharan Africa with high burdens of childhood diarrhea. We classified the quality of diarrhea management practices as good, fair, or poor based on mothers' reports for children with diarrhea, using WHO/UNICEF recommendations for appropriate treatment...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27534317/developing-a-user-centred-planning-tool-for-young-adults-with-development-disorders-a-research-based-teaching-project
#12
Kirsten Ribu, Tulpesh Patel
People with development disorders, for instance autism, need structured plans to help create predictability in their daily lives. Digital plans can facilitate enhanced independency, learning, and quality of life, but existing apps are largely general purpose and lack the flexibility required by this specific but heterogeneous user group. Universal design is both a goal and a process and should be based on a holistic approach and user-centered design, interacting with the users in all stages of the development process...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27421133/ceacam6-is-upregulated-by-helicobacter-pylori-caga-and-is-a-biomarker-for-early-gastric-cancer
#13
Rony K Roy, Michal M Hoppe, Supriya Srivastava, Animesh Samanta, Neel Sharma, Kar Tong Tan, Henry Yang, Dominic C Voon, Brendan Pang, Ming Teh, Naoko Murata-Kamiya, Masanori Hatakeyama, Young-Tae Chang, Wei Peng Yong, Yoshiaki Ito, Khek Yu Ho, Patrick Tan, Richie Soong, Phillip H Koeffler, Khay Guan Yeoh, Anand D Jeyasekharan
Early detection of gastric cancers saves lives, but remains a diagnostic challenge. In this study, we aimed to identify cell-surface biomarkers of early gastric cancer. We hypothesized that a subset of plasma membrane proteins induced by the Helicobacter pylori oncoprotein CagA will be retained in early gastric cancers through non-oncogene addiction. An inducible system for expression of CagA was used to identify differentially upregulated membrane protein transcripts in vitro. The top hits were then analyzed in gene expression datasets comparing transcriptome of gastric cancer with normal tissue, to focus on markers retained in cancer...
July 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27418320/why-cardiovascular-screening-in-young-athletes-can-save-lives-a-critical-review
#14
Jonathan A Drezner, Kimberly G Harmon, Irfan M Asif, Joseph C Marek
Cardiovascular (CV) screening in young athletes remains challenging and a topic of considerable debate. Recent criticisms of ECG screening have perpetuated arguments that ECG screening is neither indicated nor effective by applying outdated incidence data and flawed methodology. In response, this article provides a critical review of the arguments in favour of ECG screening in athletes and the early detection of CV disorders at elevated risk of sudden cardiac death (SCD). Importantly, no study to date has demonstrated that screening by history and physical examination alone is effective in detecting athletes at risk or in preventing SCD...
November 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27299147/focal-myopericarditis-as-a-rare-but-important-differential-diagnosis-of-myocardial-infarction-a-case-series
#15
Younes Nozari, Masih Tajdini, Mehdi Mehrani, Rosa Ghaderpanah
Distinguishing ST-elevation myocardial infarction (STEMI) differential diagnoses is more challenging. Myopericarditis is one of these differentials that results from viral involvement of myocardium and pericardium of the heart. Myopericarditis in focal form can mimic acute STEMI in its electrocardiogram (ECG) features and elevated cardiac enzymes. Myocarditis patients may face thrombolytic related complications such as intracranial bleeding, myocardial rupture, and hemorrhagic cardiac tamponade. Furthermore, re-administration of streptokinase (a common thrombolytic agent in our country) is banned for at least six months of previous administration; however, it can save patients' lives in emergency conditions such as massive pulmonary embolism...
2016: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/27295468/to-screen-or-not-to-screen-what-factors-influence-complex-screening-decisions
#16
Dafina Petrova, Rocio Garcia-Retamero, Andrés Catena, Joop van der Pligt
Contrary to people's intuitions, many screenings can have both benefits (e.g., lives saved) and harms (e.g., unnecessary treatments). Statistical information is often provided to ensure informed decision making. However, few theoretical models have addressed the role of comprehension of such information in screening decisions. In an experiment, we studied how cognitive skills, emotions, and a priori beliefs about screening affect comprehension of the evidence of benefits and harms from screening and intentions to get screened...
June 2016: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/27277894/physical-activity-in-european-adolescents-and-associations-with-anxiety-depression-and-well-being
#17
Elaine M McMahon, Paul Corcoran, Grace O'Regan, Helen Keeley, Mary Cannon, Vladimir Carli, Camilla Wasserman, Gergö Hadlaczky, Marco Sarchiapone, Alan Apter, Judit Balazs, Maria Balint, Julio Bobes, Romuald Brunner, Doina Cozman, Christian Haring, Miriam Iosue, Michael Kaess, Jean-Pierre Kahn, Bogdan Nemes, Tina Podlogar, Vita Poštuvan, Pilar Sáiz, Merike Sisask, Alexandra Tubiana, Peeter Värnik, Christina W Hoven, Danuta Wasserman
In this cross-sectional study, physical activity, sport participation and associations with well-being, anxiety and depressive symptoms were examined in a large representative sample of European adolescents. A school-based survey was completed by 11,110 adolescents from ten European countries who took part in the SEYLE (Saving and Empowering Young Lives in Europe) study. The questionnaire included items assessing physical activity, sport participation and validated instruments assessing well-being (WHO-5), depressive symptoms (BDI-II) and anxiety (SAS)...
June 9, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27244188/hiv-prevention-among-diverse-young-msm-research-needs-priorities-and-opportunities
#18
Scott D Rhodes, Frank Y Wong
There remains a profound need for innovative and effective interventions designed for young men who have sex with men (YMSM) generally, and racial and ethnic minority YMSM, YMSM living in rural communities, and low-income YMSM, particularly, to prevent HIV and improve health outcomes in the United States. This introduction to this theme issue, "Behavioral HIV Prevention Interventions for Diverse YMSM," of AIDS Education and Prevention identifies some of the research needs, priorities, and opportunities that emerged during a seminal NIMHD-sponsored workshop on HIV prevention behavioral interventions for diverse YMSM...
June 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27221725/-benefits-of-otoscopy-in-forensic-autopsy-practice-a%C3%A2-prospective-study
#19
Štěpánka Kučerová, Petr Hejna, Martin Dobiáš
The otoscopy is an examination of the external auditory canal, the eardrum, and the middle ear with an instrument called an otoscope. It is a simple, inexpensive, and time-saving endoscopic method typically used by general practitioners and otorhinolaryngologists. Authors present a prospective study of otoscopic findings investigated consecutively at autopsy. Of the 250 examined persons, 50 positive findings were identified: 38 cases with petechial hemorrhages and 12 cases with tympanic membrane perforation or hemotympanon...
2016: Soudní Lékarství
https://www.readbyqxmd.com/read/27187425/identifying-ethical-issues-in-mental-health-research-with-minors-adolescents-results-of-a-delphi-study
#20
Elisabeta Ioana Hiriscau, Nicola Stingelin-Giles, Danuta Wasserman, Stella Reiter-Theil
Research with minors, especially for preventive purposes, e.g., suicide prevention, investigating risk or self-destructive behaviors such as deviance, drug abuse, or suicidal behavior, is ethically sensitive. We present a Delphi study exploring the ethical implications of the needs formulated by researchers in an international pre-conference who would benefit from ethics support and guidance in conducting Mental Health Research with minors. The resulting List of Ethical Issues (LEI) was submitted to a 2-rounds Delphi process via the Internet, including 34 multidisciplinary experts...
2016: International Journal of Environmental Research and Public Health
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