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https://www.readbyqxmd.com/read/28538641/prehospital-plasma-resuscitation-associated-with-improved-neurologic-outcomes-after-traumatic-brain-injury
#1
Matthew C Hernandez, Cornelius A Thiels, Johnathon M Aho, Elizabeth B Habermann, Martin D Zielinski, James A Stubbs, Donald H Jenkins, Scott P Zietlow
INTRODUCTION: Trauma related hypotension and coagulopathy worsen secondary brain injury in patients with traumatic brain injuries (TBI). Early damage control resuscitation with blood products may mitigate hypotension and coagulopathy. Preliminary data suggest resuscitation with plasma in large animals improve neurologic function after TBI; however, data in humans are lacking. METHODS: We retrospectively identified all poly-trauma patients age >15 years with head injuries undergoing prehospital resuscitation with blood products at a single level I trauma center from 01/2002 to 12/2013...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28538329/perioperative-care-for-pediatric-patients-with-penetrating-brain-injury-a-review
#2
Marco Mikhael, Elizabeth Frost, Maria Cristancho
Traumatic brain injury (TBI) continues to be the leading cause of death and acquired disability in young children and adolescents, due to blunt or penetrating trauma, the latter being less common but more lethal. Penetrating brain injury (PBI) has not been studied extensively, mainly reported as case reports or case series, due to the assumption that both types of brain injury have common pathophysiology and consequently common management. However, recommendations and guidelines for the management of PBI differ from those of blunt TBI in regards to neuroimaging, intracranial pressure (ICP) monitoring, and surgical management including those pertaining to vascular injury...
May 19, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28534652/a-review-of-the-evidence-of-zolpidem-efficacy-in-neurological-disability-after-brain-damage-due-to-stroke-trauma-and-hypoxia-a-justification-of-further-clinical-trials
#3
J A Sutton, R P Clauss
During 15 years, 23 clinical reports and 6 studies have demonstrated associations between sub-sedative doses of zolpidem and recoveries from brain damage due to strokes, trauma and hypoxia. Clinical findings include unexpected awakenings from vegetative states and regressions of stroke symptoms after dosing that disappear during elimination and reappear on repeat dosing. Initially single-photon emission computed tomography scans showed improved perfusion within, around and distant from infarctions. Then positron emission tomography scans and electroencephalography detected renewed metabolic and neuronal activity...
May 23, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28533863/management-and-outcome-of-traumatic-brain-injury-patients-at-muhimbili-orthopaedic-institute-dar-es-salaam-tanzania
#4
Respicious Boniface, Edwin Rwebugisa Lugazia, Abel Mussa Ntungi, Othman Kiloloma
INTRODUCTION: Traumatic brain Injuries represents a significant cause of morbidity and mortality worldwide and road traffic crashes accounts for a significant proportion of these injuries. However, access to neurosurgical care is poor in low income countries like Tanzania. The aim of this study was to assess the management and outcome of Traumatic brain injury patients at a tertiary level health facility in Tanzania. METHODS: A retrospective observational study of Traumatic brain injury patients attended at Muhimbili Orthopedic Institute between January 2014 and June 2014...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28530340/-can-post-traumatic-stress-disorder-be-prevented-with-glucocorticoids
#5
REVIEW
Hagit Cohen, Zeev Kaplan, Joseph Zohar
Glucocorticoids (GCs) play a major role in orchestrating the complex physiological and behavioral reactions essential for the maintenance of homeostasis. These compounds enable the organism to prepare for, respond to and cope with the acute demands of physical and emotional stressors. The appropriate GC release, commensurate with stressor severity, enables the body to properly contain stress responses so as to promote recovery by rapidly restoring homeostasis. Indeed, inadequate GC release following stress not only delays recovery by disrupting biological homeostasis in the short run but can also interfere with the processing or interpretation of stressful information that results in long-term disruptions in memory integration...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28530073/-red-herring-complaints-in-an-eighteen-years-old-female-with-a-hydatid-cyst-of-the-lung
#6
Nasser Nadim
Brain and eye hydatid cysts are early symptomatic, as opposed to those developing in other organs, including lungs, where they remain asymptomatic through adolescence, even to adulthood, due to their slow growth. Hence, discovering that patients have lung hydatid cyst occurs, frequently, during random chest imaging. Up to thirty percent of pulmonary echinococcal cysts may rupture spontaneously, after chest or abdominal trauma. The main lung hydatidosis complaints, such as dyspnea and chest pain, are caused by the reduction of the functional area of the lung, expectoration of the tapeworm cystoides into the bronchial tree, or by compression of surrounding structures...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28529911/severe-trauma-in-the-geriatric-population
#7
REVIEW
Juan Antonio Llompart-Pou, Jon Pérez-Bárcena, Mario Chico-Fernández, Marcelino Sánchez-Casado, Joan Maria Raurich
Geriatric trauma constitutes an increasingly recognized problem. Aging results in a progressive decline in cellular function which leads to a loose of their capacity to respond to injury. Some medications commonly used in this population can mask or blunt the response to injury. Falls constitute the most common cause of trauma and the leading cause of trauma-related deaths in this population. Falls are complicated by the widespread use of antiplatelets and anticoagulants, especially in patients with brain injury...
May 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28528969/limitation-of-life-sustaining-treatment-in-severe-trauma-in-the-elderly-after-admission-to-an-intensive-care-unit
#8
Y Peñasco, A González-Castro, J C Rodríguez Borregán, M Ortiz-Lasa, R Jáuregui Solórzano, M J Sánchez Arguiano, P Escudero Acha
OBJECTIVE: To analyze the factors associated to limitation of life-sustaining treatment (LLST) measures in elderly patients admitted to an intensive care unit (ICU) due to trauma. DESIGN: A retrospective, descriptive, observational study was carried out. SETTING: ICU. PATIENTS: A total of 149 patients aged 65 years or older admitted to the ICU due to trauma. Hospital mortality, the decision to limit life-sustaining treatment and the factors associated to these measures were analyzed...
May 18, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28524120/proton-magnetic-resonance-spectroscopy-%C3%A2-h-mrs-study-of-early-traumatic-brain-injury-in-rabbits
#9
Yong Xiao, Yigang Fu, Yi Zhou, Jianguo Xia, Lina Wang, Chunhong Hu
BACKGROUND The aim of this study was to investigate the relationship between dynamic changes of cerebral metabolism and degree of trauma in rabbit models of traumatic brain injury (TBI) by using proton magnetic resonance spectroscopy (¹H-MRS). MATERIAL AND METHODS Thirty-five Chinese rabbits were randomly divided into control, mild, moderate, and severe TBI groups. ¹H-MRS was performed 1, 6, and 24 h after trauma. The concentrations of NAA, Cr, Cho, and Lac, and NAA/Cr and Cho/Cr ratios in each group, were estimated...
May 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28520672/sertraline-for-major-depression-during-the-year-following-traumatic-brain-injury-a-randomized-controlled-trial
#10
Jesse R Fann, Charles H Bombardier, Nancy Temkin, Peter Esselman, Catherine Warms, Jason Barber, Sureyya Dikmen
OBJECTIVE: Major depressive disorder (MDD) is common and associated with impaired functioning after traumatic brain injury (TBI). Few placebo-controlled antidepressant trials exist in this population. We evaluated the efficacy and tolerability of sertraline for MDD within 1 year of sustaining a TBI. SETTING: Level I trauma center. PARTICIPANTS: Adults with MDD within 1 year of hospitalization for complicated mild to severe TBI. DESIGN: Randomized, double-blind, placebo-controlled trial...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520670/neutrophil-to-lymphocyte-ratio-as-a-novel-predictor-of-outcome-in-patients-with-severe-traumatic-brain-injury
#11
Weiqiang Chen, Jinhua Yang, Bingbing Li, Guoyi Peng, Tianfei Li, Lianjie Li, Shousen Wang
OBJECTIVE: The neutrophil to lymphocyte ratio (NLR) has been reported to be a predictor of outcome in critical illness. Objective of this study was to investigate the changes of the NLR in patients with severe traumatic brain injury (TBI) and analyze the relationship between the NLR and TBI outcome. SETTING: China. PARTICIPANTS: A total of 855 patients with severe TBI from January 2007 to April 2012. DESIGN: Retrospective...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28520664/follow-up-care-adherence-after-hospital-discharge-in-children-with-traumatic-brain-injury
#12
Alexandra J Spaw, Jennifer P Lundine, Sarah A Johnson, Jin Peng, Krista K Wheeler, Junxin Shi, Ginger Yang, Kathy J Haley, Jonathan I Groner, Henry Xiang
OBJECTIVE: To investigate factors associated with follow-up care adherence in children hospitalized because of traumatic brain injury (TBI). DESIGN: An urban level 1 children's hospital trauma registry was queried to identify patients (2-18 years) hospitalized with a TBI in 2013 to 2014. Chart reviewers assessed discharge summaries and follow-up instructions in 4 departments. MAIN MEASURES: Three levels of adherence-nonadherence, partial adherence, and full adherence-and their associations with care delivery, patient, and injury factors...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28508521/an-incidental-diffuse-midline-glioma-found-at-autopsy
#13
Meggen Walsh, William Hamilton, Vektra Casler, Anthony Yachnis
This case shows an unexpected midline glioma found at autopsy. Two siblings were riding on a single bicycle on the side of a road. The 13-year-old brother was seated and steering the bicycle, while the 14-year-old sister held onto the back. The bicycle veered left into traffic and was struck by a vehicle. The siblings were admitted to the local Level 1 trauma center, but both later succumbed to injuries. Autopsies were performed on the children, including brains for neuropathologic evaluation. The brother was found to have an infiltrating astrocytoma located in the left middle cerebellar peduncle, with extension to the pons and medulla...
May 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28508360/genome-to-phenome-a-systems-biology-approach-to-ptsd-using-an-animal-model
#14
Nabarun Chakraborty, James Meyerhoff, Marti Jett, Rasha Hammamieh
Post-traumatic stress disorder (PTSD) is a debilitating illness that imposes significant emotional and financial burdens on military families. The understanding of PTSD etiology remains elusive; nonetheless, it is clear that PTSD is manifested by a cluster of symptoms including hyperarousal, reexperiencing of traumatic events, and avoidance of trauma reminders. With these characteristics in mind, several rodent models have been developed eliciting PTSD-like features. Animal models with social dimensions are of particular interest, since the social context plays a major role in the development and manifestation of PTSD...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28506081/epidemiological-characteristics-of-chinese-paediatric-traumatic-brain-injury-inpatients
#15
Yunming Li, Fuqin Chen, Junran Zhang, Gang Li, Xiaoguang Yang, Qiang Lu, Xun Xia, Xinyan Zhang, Jun Qiu, Junpeng Zhang, Jihong Zhou, Yongqin Kuang, Jianwen Gu
PRIMARY OBJECTIVE: To investigate the epidemiological characteristics of paediatric inpatients with traumatic brain injury (TBI) in China. RESEARCH DESIGN: The Chinese Trauma Database (CTD), a nationwide register system based on hospital admission data, contains diagnosis and treatment information for trauma inpatients in over 200 military-managed public-service hospitals in China. Using the ICD-9 coding, the data for children with TBI aged 0-17 years between 2001 and 2007 were retrieved...
May 16, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28503462/predictors-for-depressive-mood-in-geriatric-patients-after-traumatic-brain-injury-a-retrospective-cross-sectional-study
#16
Je Kyung Kim, Na Young Kim, Yong Wook Kim
OBJECTIVE: To identify predictors for depressive mood in geriatric patients after traumatic brain injury (TBI). METHODS: A retrospective review of patients' medical charts was performed in TBI patients who were older than 60 years and referred to the Department of Rehabilitation Medicine at Severance Hospital in 2002-2016. The patients were classified into two groups based on the Geriatric Depression Scale (GDS): non-depressive group (0≤GDS≤16) and depressive group (17≤GDS≤30)...
April 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28499787/motocross-associated-head-and-spine-injuries-in-adult-patients-evaluated-in-an-emergency-department
#17
Lucas Oliveira J E Silva, M Fernanda Bellolio, Elisa M Smith, David J Daniels, Christine M Lohse, Ronna L Campbell
BACKGROUND: Motor vehicle-related injuries (including off-road) are the leading cause of traumatic brain injury (TBI) and acute traumatic spinal cord injury in the United States. OBJECTIVES: To describe motocross-related head and spine injuries of adult patients presenting to an academic emergency department (ED). METHODS: We performed an observational cohort study of adult ED patients evaluated for motocross-related injuries from 2010 through 2015...
April 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28495236/fireworks-type-injury-pattern-and-permanent-impairment-following-severe-fireworks-related-injuries
#18
Brinkley K Sandvall, Lauren Jacobson, Erin A Miller, Ryan E Dodge, D Alex Quistberg, Ali Rowhani-Rahbar, Monica S Vavilala, Jeffrey B Friedrich, Kari A Keys
BACKGROUND: There is a paucity of clinical data on severe fireworks-related injuries, and the relationship between firework types, injury patterns, and magnitude of impairment is not well understood. Our objective was to describe the relationship between fireworks type, injury patterns, and impairment. METHODS: Retrospective case series (2005-2015) of patients who sustained consumer fireworks-related injuries requiring hospital admission and/or an operation at a Level 1 Trauma/Burn Center...
April 25, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28495204/intracranial-pressure-monitoring-in-severe-traumatic-brain-injuries-a-closer-look-at-level-1-trauma-centers-in-the-united-states
#19
Piccinini Alice, Lewis Meghan, Benjamin Elizabeth, Aiolfi Alberto, Inaba Kenji, Demetriades Demetrios
INTRODUCTION: The Brain Trauma Foundation (BTF) recently updated recommendations for intracranial pressure (ICP) monitoring in severe traumatic brain injury (TBI). The effect of ICP monitoring on outcomes is controversial, and compliance with BTF guidelines is variable. The purpose of this study was to assess both compliance and outcomes at level I trauma centers. MATERIALS AND METHODS: The American College of Surgeons Trauma Quality Improvement Program database was queried for all patients admitted to level I trauma centers with isolated blunt severe TBI (AIS>3, GCS<9) who met criteria for ICP monitoring...
April 20, 2017: Injury
https://www.readbyqxmd.com/read/28493608/the-epidemiology-of-emergency-department-trauma-discharges-in-the-united-states
#20
Charles J DiMaggio, Jacob B Avraham, David C Lee, Spiros G Frangos, Stephen P Wall
OBJECTIVE: Injury related morbidity and mortality is an important emergency medicine and public health challenge in the United States (US). Here we describe the epidemiology of traumatic injury presenting to US emergency departments, define changes in types and causes of injury among the elderly and the young, characterize the role of trauma centers and teaching hospitals in providing emergency trauma care, and estimate the overall economic burden of treating such injuries. METHODS: We conducted a secondary retrospective, repeated cross-sectional study of the Nationwide Emergency Department Data Sample (NEDS), the largest all-payer emergency department survey database in the US...
May 11, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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