keyword
MENU ▼
Read by QxMD icon Read
search

Long acting injectable

keyword
https://www.readbyqxmd.com/read/28107404/patterns-of-contraceptive-adoption-continuation-and-switching-after-delivery-among-malawian-women
#1
Dawn M Kopp, Nora E Rosenberg, Gretchen S Stuart, William C Miller, Mina C Hosseinipour, Phylos Bonongwe, Mwawi Mwale, Jennifer H Tang
Women who report use of postpartum family planning may not continue their initial method or use it consistently. Understanding the patterns of method uptake, discontinuation, and switching among women after delivery is important to promote uptake and continuation of effective methods of contraception. This is a secondary analysis of 634 Malawian women enrolled into a prospective cohort study after delivery. They completed baseline surveys upon enrollment and follow-up telephone surveys 3, 6, and 12 months post-delivery...
2017: PloS One
https://www.readbyqxmd.com/read/28093111/efficacy-of-tildipirosin-metaphylaxis-for-the-prevention-of-respiratory-disease-otitis-and-mortality-in-pre-weaned-holstein-calves
#2
A G V Teixeira, J A A McArt, R C Bicalho
The aim of this study was to evaluate the efficacy of two metaphylactic approaches (long acting antibiotic injected once at 10 days of life or twice at 10 and 35 days of life) on the prevention of bovine respiratory disease (BRD), otitis and mortality in high-risk group-housed pre-weaned Holstein heifer calves. The antibiotic of choice for the metaphylactic approach was a long acting macrolide (tildipirosin) administered subcutaneously at the base of the neck at a dose of 1 mL per 45 kg body weight. A clinical trial was carried out on one dairy farm with random allocation of newborn calves to one of three treatments: (1) control (CTR); (2) one injection at 10 days of life (M1); and (3) two injections at 10 and 35 days of life (M2)...
January 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28068780/long-acting-injectable-naltrexone-induction-a-randomized-trial-of-outpatient-opioid-detoxification-with-naltrexone-versus-buprenorphine
#3
Maria Sullivan, Adam Bisaga, Martina Pavlicova, C Jean Choi, Kaitlyn Mishlen, Kenneth M Carpenter, Frances R Levin, Elias Dakwar, John J Mariani, Edward V Nunes
OBJECTIVE: At present there is no established optimal approach for transitioning opioid-dependent adults to extended-release injection naltrexone (XR-naltrexone) while preventing relapse. The authors conducted a trial examining the efficacy of two methods of outpatient opioid detoxification for induction to XR-naltrexone. METHOD: Participants were 150 opioid-dependent adults randomly assigned 2:1 to one of two outpatient detoxification regimens, naltrexone-assisted detoxification or buprenorphine-assisted detoxification, followed by an injection of XR-naltrexone...
January 10, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28063803/tamoxifen-and-ici-182-780-activate-hypothalamic-g-protein-coupled-estrogen-receptor-1-to-rapidly-facilitate-lordosis-in-female-rats
#4
Nathan Long, Bertha Long, Asma Mana, Dream Le, Lam Nguyen, Sima Chokr, Kevin Sinchak
In the female rat, sexual receptivity (lordosis) can be facilitated by sequential activation of estrogen receptor (ER) α and G protein-coupled estrogen receptor 1 (GPER) by estradiol. In the estradiol benzoate (EB) primed ovariectomized (OVX) rat, EB initially binds to ERα in the plasma membrane that complexes with and transactivates metabotropic glutamate receptor 1a to activate β-endorphin neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN). This activates MPN μ-opioid receptors (MOP), inhibiting lordosis...
January 4, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28055336/treatment-persistence-and-hospitalization-rates-among-patients-with-schizophrenia-a-quasi-experiment-to-evaluate-a-patient-information-program
#5
Dominic Pilon, Tony B Amos, Guillaume Germain, Marie-Hélène Lafeuille, Patrick Lefebvre, Carmela J Benson
OBJECTIVE: The effective treatment of schizophrenia requires continuous antipsychotic maintenance therapy. However, poor persistence of treatment is common among patients with schizophrenia. The objective of this study was to compare persistence and hospitalization rates among patients with schizophrenia treated with long-acting injectable (LAI) antipsychotics (i.e., paliperidone palmitate and risperidone) and enrolled in a patient information program (program cohort) with patients treated with oral antipsychotics (OAs) who were not enrolled in a patient information program (nonprogram cohort)...
January 5, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28044942/emerging-pharmacological-therapies-in-schizophrenia-what-s-new-what-s-different-what-s-next
#6
Leslie Citrome
There are several new and emerging medication interventions for both the acute and maintenance treatment phases of schizophrenia. Recently approved are 2 new dopamine receptor partial agonists, brexpiprazole and cariprazine, as well as 2 new long-acting injectable antipsychotic formulations, aripiprazole lauroxil and 3-month paliperidone palmitate. Although differences in efficacy compared to other available choices are not expected, the new oral options offer different tolerability profiles that may be attractive for individual patients who have had difficulties with older medications...
December 2016: CNS Spectrums
https://www.readbyqxmd.com/read/28011981/nicotine-induced-enhancement-of-pavlovian-alcohol-seeking-behavior-in-rats
#7
Jean-Marie N Maddux, Nadia Chaudhri
RATIONALE: Nicotine enhances responding elicited by Pavlovian cues that predict positive outcomes. OBJECTIVES: We tested the hypothesis that nicotine acting at nicotinic acetylcholine receptors (nAChRs) would augment Pavlovian alcohol-seeking. METHODS: Male, Long-Evans rats with unrestricted access to food and water were acclimated to drinking 15% ethanol in their home cages and then given Pavlovian conditioning sessions in which each trial of a 15-s conditioned stimulus (CS, 12 trials/session) was paired with 0...
December 23, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/28011389/extended-release-naltrexone-for-pre-release-prisoners-a-randomized-trial-of-medical-mobile-treatment
#8
Michael S Gordon, Frank J Vocci, Terrence T Fitzgerald, Kevin E O'Grady, Charles P O'Brien
BACKGROUND: Extended-release naltrexone (XR-NTX), is an effective treatment for opioid use disorder but is rarely initiated in US prisons or with criminal justice populations. Mobile treatment for chronic diseases has been implemented in a variety of settings. Mobile treatment may provide an opportunity to expand outreach to parolees to surmount barriers to traditional clinic treatment. METHODS: Male and female prisoners (240) with pre-incarceration histories of opioid use disorder who are within one month of release from prison will be enrolled in this randomized clinical trial...
December 20, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28007820/curbing-publicly-funded-family-planning-services-in-iran-who-is-affected
#9
Amir Erfani
OBJECTIVE: In response to a persistent low fertility rate in the country, the Supreme Leader of Iran in 2012 called for the shift to pronatalist population policies. Consequently, Iran's Parliament proposed a bill to curb the provision of contraceptive knowledge and services as a solution to raising the country's low fertility rate. This study aimed to investigate which groups of women will be adversely affected if the provision of subsidised contraceptive methods [i.e. sterilisation, intrauterine device (IUD) and injections] is curbed...
January 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28004623/new-ema-report-on-paliperidone-3-month-injections-taking-clinical-and-policy-decisions-without-an-adequate-evidence-base
#10
G Ostuzzi, D Papola, C Gastaldon, C Barbui
Three-month long-acting paliperidone is a new, recently marketed, formulation of paliperidone, characterised by the longest available dosing interval among long-acting antipsychotics. The clinical profile of 3-month long-acting paliperidone was recently summarised by the European Medicines Agency (EMA) in a public assessment report, released in April 2016. In this commentary, the main strengths and limitations of the EMA assessment report were appraised and discussed, in order to highlight possible implications for clinical practice, future research and regulatory practices for drug approval...
December 22, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28004300/effect-of-wenhua-juanbi-recipe-on-expression-of-receptor-activator-of-nuclear-factor-kappa-b-ligand-osteoprotegerin-and-tumor-necrosis-factor-receptor-superfamily-member-14-in-rats-with-collagen-induced-arthritis
#11
Xi-de Liu, Yun-Qing Wang, Long Cai, Li-Hong Ye, Fang Wang, Ying-Ying Feng
OBJECTIVE: To study the effect of Wenhua Juanbi Recipe (, WJR) on expression of receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and tumor necrosis factor receptor superfamily member 14 (TNFRSF14, also known as LIGHT) in rats with collagen-induced arthritis (CIA). METHODS: CIA rats were generated by subcutaneous injection of bovine collagen type-II at the tail base. Sixty CIA rats were randomly assigned (10 animals/group) to: model, methotrexate (MTX)-treated (0...
December 21, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27994714/factors-associated-with-adherence-to-the-hedis-quality-measure-in-medicaid-patients-with-schizophrenia
#12
Marie-Hélène Lafeuille, Christian Frois, Michel Cloutier, Mei Sheng Duh, Patrick Lefebvre, Jacqueline Pesa, Zoe Clancy, John Fastenau, Mike Durkin
BACKGROUND: Treatment continuity is a major challenge in the long-term management of patients with schizophrenia; poor patient adherence to antipsychotic drugs has been associated with negative clinical outcomes. Long-acting injectable therapies may improve adherence and lessen the risk for psychiatric-related relapse, often leading to rehospitalization and higher healthcare costs. Therefore, understanding the determinants of adherence to antipsychotics is critical in the management of patients with schizophrenia...
October 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27990008/anemia-treatment-by-erythropoiesis-stimulating-agents-during-the-6-months-before-initiation-of-hemodialysis-comparison-between-darbepoetin-alfa-and-continuous-erythropoietin-receptor-activator
#13
Tadashi Yoshida, Matsuhiko Hayashi
Anemia in chronic kidney disease (CKD) is a risk factor for cardiovascular diseases and is treated by long-acting erythropoiesis-stimulating agents (ESA). Although results of previous studies showed that the hemoglobin level could not be maintained at initiation of dialysis in CKD patients treated with recombinant human erythropoietin, it remains undetermined if long-acting ESA are effective to prevent the progression of anemia at initiation of dialysis. In the present study, hemoglobin levels in 40 CKD patients treated with darbepoetin alfa (DA) and 15 CKD patients treated with a continuous erythropoietin receptor activator (CERA) were retrospectively compared during the 6 months period prior to initiation of dialysis...
December 19, 2016: Keio Journal of Medicine
https://www.readbyqxmd.com/read/27986986/a-pharmacokinetic-study-of-lipegfilgrastim-in-children-with-ewing-family-of-tumors-or-rhabdomyosarcoma
#14
Margarita B Belogurova, Zoryana P Kizyma, Miklós Garami, Mónika Csóka, Michael J Lamson, Anton Buchner, Peter Bias, Andreas Lammerich
PURPOSE: Neutropenia is a common complication from chemotherapy, limiting optimal dosing and treatment. Lipegfilgrastim is a long-acting granulocyte colony-stimulating factor developed for the management of chemotherapy-induced neutropenia. The objectives of this phase 1, multinational, open-label, single-arm study were to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of a single body weight-adjusted dose of lipegfilgrastim and to evaluate the efficacy, safety, and tolerability of the drug in children with Ewing family of tumors or rhabdomyosarcoma treated with myelosuppressive chemotherapy...
December 16, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27986922/cocaine-promotes-coincidence-detection-and-lowers-induction-threshold-during-hebbian-associative-synaptic-potentiation-in-prefrontal-cortex
#15
Hongyu Ruan, Wei-Dong Yao
: Addictive drugs usurp neural plasticity mechanisms that normally serve reward-related learning and memory, primarily by evoking changes in glutamatergic synaptic strength in the mesocorticolimbic dopamine circuitry. Here we show that repeated cocaine exposure in vivo does not alter synaptic strength in the mouse prefrontal cortex during an early period of withdrawal, but instead modifies a Hebbian quantitative synaptic learning rule by broadening the temporal window and lowers the induction threshold for spike timing-dependent LTP (t-LTP)...
December 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27984447/local-zinc-chloride-release-from-a-calcium-sulfate-carrier-enhances-fracture-healing
#16
Ethan S Krell, Joseph A Ippolito, Nicholas J Montemurro, Phillip H Lim, Richard A Vincent, Jeremy Hreha, Jessica Cottrell, Suleiman Y Sudah, Maximilian F Muñoz, Kristen P Pacific, Joseph Benevenia, J Patrick O'Connor, Sheldon S Lin
BACKGROUND: This study examined the efficacy of calcium sulfate (CaSO4) as a carrier for intramedullary delivery of zinc chloride (ZnCl2) to treat fracture healing in a BB Wistar rat model. A non-carrier mediated injection of 3.0 mg/kg ZnCl2 has previously been shown to enhance fracture healing. METHODS: A heterogeneous mixture of ZnCl2 and CaSO4 was administered into the intramedullary femoral canal and a mid-diaphyseal femur fracture was created unilaterally. Early and late parameters of fracture healing were assessed using biomechanical testing, radiographic scoring, quantitative histomorphometry (for percentage of new cartilage and bone within the fracture callus), and long term histological evaluation...
November 16, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27981717/effect-of-varying-degrees-of-renal-impairment-on-the-pharmacokinetics-and-tolerability-of-taspoglutide
#17
Mylène Giraudon, Stefan Sturm, Nathalie Lambert, Markus Niggli, Jochen Brumm, Bernhard Mangold, Christophe Schmitt
AIMS: Taspoglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist which demonstrated meaningful anti-hyperglycaemic and weight loss effects in type 2 diabetic patients. The present study evaluated single dose pharmacokinetics and tolerability of taspoglutide in subjects with varying degrees of renal impairment and matched healthy subjects. METHOD: Subjects with mild renal impairment (n = 10), moderate impairment (n = 10), severe impairment (n = 9), or their matched healthy controls (n = 10) participated in this study...
December 15, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27971818/impact-of-initiation-of-long-acting-injectable-antipsychotics-on-resource-utilization-in-patients-with-schizophrenia
#18
J Lachaine, M Larbi, P Melnyk, A Rouleau, V Baribeau, E Stip
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971420/retrospective-database-study-describing-patient-characteristics-and-resource-use-in-swedish-patients-receiving-second-generation-long-acting-injection-antipsychotics
#19
E Hernlund, E Landfeldt, L A Lombard, A Tockhorn-Heidenreich, C Bushe, V Porsdal, J Eriksson, J Berg
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971390/economic-aspects-in-the-treatment-of-schizophrenia-in-italy-cost-consequences-of-an-early-long-acting-injectable-antipsychotics-lais-approach
#20
A Marcellusi, F S Mennini, R Brugnoli, C Rapinesi, G D Kotzalidis, S De Filippis, D Carrus, A Ballerini, A Francomano, G Ducci, A Del Casale, P Girardi
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
keyword
keyword
94379
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"