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https://www.readbyqxmd.com/read/29350127/converting-oral-to-long-acting-injectable-antipsychotics-a-guide-for-the-perplexed
#1
Jonathan M Meyer
There has been increasing recognition that antipsychotic nonadherence is common across all stages of schizophrenia, starting from the first episode. Moreover, numerous meta-analyses of the existing literature indicate superiority of long-acting injectable (LAI) over oral antipsychotics when one adjusts for the greater illness severity and duration among patients in LAI antipsychotic trials. The increasing availability of LAI antipsychotic options has raised interest in converting patients from oral medication; however, the successful transition from oral to the comparable LAI antipsychotic requires an understanding of the current extent of antipsychotic exposure, the kinetics of the LAI preparation, and the expected plasma levels achieved by the LAI formulation...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29347858/where-are-we-with-injectables-against-hiv-infection-and-what-are-the-remaining-challenges
#2
Said A Hassounah, Thibault Mesplède
Drug adherence has been a recurring issue in the field of HIV treatment, and low treatment adherence is typically associated with emergence of drug resistance, treatment failure and increased risks of transmission. Injectable antiretroviral drugs offer a unique opportunity to counter this issue for the treatment of HIV-positive individuals. In addition, injectables offer a remarkable opportunity to reduce new HIV infections, if applied in the context of both treatment-as-prevention and pre-exposure prophylaxis...
January 19, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29345879/improving-long-term-outcomes-in-patients-with-schizophrenia-what-is-the-evidence-for-long-acting-injectable-antipsychotics
#3
Diana O Perkins
Do you consider long-acting injectable (LAI) antipsychotics when selecting among treatments for schizophrenia? Take part in this CME activity to review the evidence for LAIs vs oral medications and to learn which patients may benefit most from this treatment option. Plus, discover the pharmacokinetic properties of LAIs and barriers to their use.
November 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29343980/peripheral-and-spinal-trpa1-channels-contribute-to-formalin-induced-long-lasting-mechanical-hypersensitivity
#4
Vladimir A Martínez-Rojas, Guadalupe García, Roxana Noriega-Navarro, Crystell G Guzmán-Priego, Jorge E Torres-López, Vinicio Granados-Soto, Janet Murbartián
Background: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed by a subset of nociceptive neurons that acts as a multimodal receptor. Its activity contributes to modulate nociceptive transmission in acute inflammatory pain. However, the role of this channel in chronic pain has been less studied. The purpose of this study was to investigate the local peripheral and spinal participation of TRPA1 channels in formalin-induced long-lasting hypersensitivity...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29341822/aripiprazole-long-acting-injectable-for-maintenance-treatment-of-bipolar-i-disorder-in-adults
#5
Arpit Aggarwal, Lindsey Schrimpf, John Lauriello
Bipolar I disorder is a serious and disabling psychiatric illness. It is associated with a significant reduction in quality of life and an increased risk for suicide. Pharmacotherapy is essential for both the acute and maintenance treatment of bi-polar I disorder. While multiple oral medications are recommended for the maintenance treatment, there are not many long-acting injectable medications approved for this indication. New treatments that would improve patient adherence have the potential for decreasing relapses and improving patients' ability to remain functional members of society...
January 2018: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29334997/effects-of-three-frequencies-of-self-monitored-blood-glucose-on-hba1c-and-quality-of-life-in-patients-with-type-2-diabetes-with-once-daily-insulin-and-stable-control-a-randomized-trial
#6
Johanna Hortensius, Nanne Kleefstra, Gijs W D Landman, Bas T Houweling, Klaas H Groenier, Jaap J van der Bijl, Henk Bilo
OBJECTIVE: The optimal frequency of self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes (T2DM) with stable glycemic control is unknown. This study investigated effects of 3 frequencies of SMBG on glycemic control and quality of life after 9 months in patients using one long-acting insulin injection a day. In an open-label, multi-center, primary-care, parallel (1:1:1) randomized trial in the Netherlands including patients with T2DM, HbA1c ≤ 58 mmol/mol (≤ 7...
January 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29329878/course-dose-and-stage-dependent-toxic-effects-of-prenatal-dexamethasone-exposure-on-fetal-articular-cartilage-development
#7
Ze Chen, Zhe Zhao, Yunzepeng Li, Xingyu Zhang, Bin Li, Liaobin Chen, Hui Wang
Dexamethasone, a synthetic long-acting glucocorticoid, is routinely used for treating mothers at risk for preterm delivery. However, intrauterine overexposure to glucocorticoids induces low birth weight and cartilage dysplasia in offspring. Also, the "critical window" and safe dose of this treatment are largely unknown. This study investigated the course-, dose-, and stage-dependent toxic effects and the possible mechanisms of prenatal dexamethasone exposure (PDE) on fetal development and articular cartilage development...
January 9, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29327960/pharmacokinetics-of-a-single-intramuscular-injection-of-long-acting-ceftiofur-crystalline-free-acid-in-cattle-egrets-bubulcus-ibis
#8
Jennifer A Waldoch, Sherry K Cox, Douglas L Armstrong
We determined the pharmacokinetic properties of ceftiofur crystalline-free acid (CCFA), a long-acting antibiotic, after a single intramuscular injection in cattle egrets ( Bubulcus ibis). A dose of 20 mg/kg was administered intramuscularly to 18 birds and blood samples were collected via jugular venipuncture at 1, 2, 4, 8, 12, 24, 48, 72, 96, 120, 144, 168, 192, 216, and 240 hours after CCFA administration. Plasma concentrations of ceftiofur free acid equivalents (CFAEs) were measured via high-performance liquid chromatography...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29318424/pasireotide-does-not-improve-efficacy-of-aspiration-sclerotherapy-in-patients-with-large-hepatic-cysts-a-randomized-controlled-trial
#9
Titus F M Wijnands, Tom J G Gevers, Marten A Lantinga, René H Te Morsche, Leo J Schultze Kool, Joost P H Drenth
OBJECTIVES: We tested whether complementary use of the somatostatin analogue pasireotide would augment efficacy of aspiration sclerotherapy of hepatic cysts. METHODS: We conducted a double-blind, placebo-controlled trial in patients who underwent aspiration sclerotherapy of a large (>5 cm) symptomatic hepatic cyst. Patients were randomized to either intramuscular injections of pasireotide 60 mg long-acting release (n = 17) or placebo (sodium chloride 0.9 %, n = 17)...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29313971/in-vivo-antitumor-function-of-tumor-antigen-specific-ctls-generated-in-the-presence-of-ox40-co-stimulation-in-vitro
#10
Ngoc Pham Minh, Satoshi Murata, Naomi Kitamura, Tomoyuki Ueki, Masatsugu Kojima, Toru Miyake, Katsushi Takebayashi, Hirokazu Kodama, Eiji Mekata, Masaji Tani
Adoptive cell transfer (ACT) is an emerging and promising cancer immunotherapy that has been improved through various approaches. Here, we described the distinctive characteristics and functions of tumor Ag-specific effector CD8+ T-cells, co-cultured with a tumor specific peptide and a stimulatory anti-OX40 antibody, before being used for ACT therapy in tumor-bearing mouse recipients. Splenic T-cells were obtained from wild-type FVB/N mice that had been injected with a HER2/neu (neu)-expressing tumor and a neu-vaccine...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29310682/upregulation-of-the-long-non-coding-rna-afap1-as1-affects-the-proliferation-invasion-and-survival-of-tongue-squamous-cell-carcinoma-via-the-wnt-%C3%AE-catenin-signaling-pathway
#11
Ze-You Wang, Min Hu, Min-Hui Dai, Jing Xiong, Shuai Zhang, Han-Jiang Wu, Shan-Shan Zhang, Zhao-Jian Gong
BACKGROUND: Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an antisense direction to the protein-coding gene AFAP1 in the opposite strand. Previous studies showed that lncRNA AFAP1-AS1 was upregulated and acted as an oncogene in a variety of tumors. However, the expression and biological functions of lncRNA AFAP1-AS1 in tongue squamous cell carcinoma (TSCC) are still unknown. METHODS: The expression level of AFAP1-AS1 was measured in 103 pairs of human TSCC tissues and corresponding adjacent normal tongue mucous tissues...
January 8, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29304154/experiences-with-long-acting-injectable-art-a-qualitative-study-among-plhiv-participating-in-a-phase-ii-study-of-cabotegravir-rilpivirine-latte-2-in-the-united-states-and-spain
#12
Deanna Kerrigan, Andrea Mantsios, Miguel Gorgolas, Maria-Luisa Montes, Federico Pulido, Cynthia Brinson, Jerome deVente, Gary J Richmond, Sarah W Beckham, Paige Hammond, David Margolis, Miranda Murray
Challenges with adherence to daily oral antiretroviral therapy (ART) among people living with HIV (PLHIV) have stimulated development of injectable long-acting (LA) regimens. We conducted 39 in-depth interviews with participants and providers in a Phase IIb study (LATTE-2) evaluating an injectable LA regimen in the U.S. and Spain. Interviews exploring participant and provider attitudes and experiences with LA versus oral ART were audiotaped, transcribed and analyzed using thematic content analysis. Participants described the convenience of LA injections versus daily pills and emotional benefits such as minimized potential for HIV disclosure and eliminating the "daily reminder of living with HIV...
2018: PloS One
https://www.readbyqxmd.com/read/29290806/multimodal-theranostic-nanoformulations-permit-magnetic-resonance-bioimaging-of-antiretroviral-drug-particle-tissue-cell-biodistribution
#13
Bhavesh D Kevadiya, Christopher Woldstad, Brendan M Ottemann, Prasanta Dash, Balasrinivasa R Sajja, Benjamin Lamberty, Brenda Morsey, Ted Kocher, Rinku Dutta, Aditya N Bade, Yutong Liu, Shannon E Callen, Howard S Fox, Siddappa N Byrareddy, JoEllyn M McMillan, Tatiana K Bronich, Benson J Edagwa, Michael D Boska, Howard E Gendelman
RATIONALE: Long-acting slow effective release antiretroviral therapy (LASER ART) was developed to improve patient regimen adherence, prevent new infections, and facilitate drug delivery to human immunodeficiency virus cell and tissue reservoirs. In an effort to facilitate LASER ART development, "multimodal imaging theranostic nanoprobes" were created. These allow combined bioimaging, drug pharmacokinetics and tissue biodistribution tests in animal models. METHODS: Europium (Eu3+)- doped cobalt ferrite (CF) dolutegravir (DTG)- loaded (EuCF-DTG) nanoparticles were synthesized then fully characterized based on their size, shape and stability...
2018: Theranostics
https://www.readbyqxmd.com/read/29290075/expanding-the-menu-of-hiv-prevention-options-a-qualitative-study-of-experiences-with-long-acting-injectable-cabotegravir-as-prep-in-the-context-of-a-phase-ii-trial-in-the-united-states
#14
D Kerrigan, A Mantsios, R Grant, M Markowitz, P Defechereux, M La Mar, S W Beckham, P Hammond, D Margolis, M Murray
Adherence challenges with oral pre-exposure prophylaxis have stimulated interest in alternate modes of administration including long-acting injections. We conducted 30 in-depth interviews with 26 male trial participants and 4 clinical providers in a Phase IIa study (ÉCLAIR) evaluating the use of long-acting cabotegravir (CAB-LA) injections in New York and San Francisco. Interviews exploring attitudes and experiences with CAB-LA were audiotaped, transcribed, and analyzed using thematic content analysis. Despite a high frequency of some level of side effects, almost all participants reported being interested in continuing with CAB-LA, versus a daily oral, due to its convenience and the perceived advantage of not worrying about adhering to pills...
December 30, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29284436/health-care-use-drug-treatment-and-comorbidity-in-patients-with-schizophrenia-or-non-affective-psychosis-in-sweden-a-cross-sectional-study
#15
Erica M Brostedt, Mussie Msghina, Marie Persson, Björn Wettermark
BACKGROUND: This study investigated the prevalence of schizophrenia (ICD-10 F 20) and of other non-affective psychosis (NAP, ICD-10 F 21 - F 29) in Sweden. It further assessed health care use, comorbidity and medication for these patient groups. Most studies either have a study population of patients with strictly defined schizophrenia or a psychosis population of which strict schizophrenia cases form a smaller set. The present study permits comparison of the two mutually exclusive patient groups using data at the individual level in the diagnosis of non-affective psychosis, use of health care, medical treatment and comorbidity by diagnosis or medical treatment...
December 29, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29280667/-intragastric-injection-of-botulinum-toxin-a-real-alternative-for-obesity-treatment-a-systematic-review
#16
Francisco José Sánchez Torralvo, Sergio Valdés Hernández, María José Tapia, José Abuín Fernández, Gabriel Olveira
BACKGROUND: Obesity is a prevalent disease in our environment, which comorbidities suppose a great challenge to public health. Intragastric injection of botulinum toxin has been used as treatment for obesity, both in humans and animals. It acts by inhibiting gastric emptying and inducing early satiety, consequently reducing intake and finally achieving weight loss. MATERIALS AND METHODS: A bibliographic search in PubMed, Scopus and EMBASE databases between 2000 and 2016 was carried out...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29275047/reduced-lordosis-and-enhanced-aggression-in-paced-and-non-paced-mating-in-diabetic-female-rats
#17
Abigail K Hernández-Munive, Daniela Rebolledo-Solleiro, Elisa Ventura-Aquino, Alonso Fernández-Guasti
BACKGROUND: Clinical studies have shown altered sexual function in people with diabetes; basic science studies, using the streptozotocin (STZ)-induced animal model of type 1 diabetes mellitus (DM1), have consistently reported decreased sexual behavior in hyperglycemic female animals, but features of sexual motivation and aggressive behavior have not been explored in these animals. AIM: To study several parameters that denote sexual motivation in STZ-treated female rats and to compare behavioral features of sexual behavior and aggression in non-paced mating (NPM) and paced mating (PM) conditions...
December 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29274734/antipsychotics-and-mortality-in-a-nationwide-cohort-of-29-823-patients-with-schizophrenia
#18
Heidi Taipale, Ellenor Mittendorfer-Rutz, Kristina Alexanderson, Maila Majak, Juha Mehtälä, Fabian Hoti, Erik Jedenius, Dana Enkusson, Amy Leval, Jan Sermon, Antti Tanskanen, Jari Tiihonen
INTRODUCTION: It has remained controversial if antipsychotic treatment is associated with increased or decreased mortality among patients with schizophrenia, and if there are any clinically meaningful differences between specific agents and routes of administration. METHODS: We linked prospectively gathered nationwide register-based data during 2006-2013 to study all-cause mortality among all patients aged 16-64years with schizophrenia in Sweden (N=29,823 in total; N=4603 in the incident cohort)...
December 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29273485/a-first-in-man-phase-1-trial-for-long-acting-transcon-growth-hormone
#19
David Gilfoyle, Eva Mortensen, Eva Dam Christoffersen, Jonathan A Leff, Michael Beckert
TransCon growth hormone (GH) is a sustained-release inactive prodrug consisting of unmodified GH transiently bound to an inert carrier molecule designed to release fully active GH over a one-week period. This was a first-in-man phase 1 randomized trial was to evaluate the safety, tolerability, immunogenicity, pharmacokinetics (PK), and pharmacodynamics (PD) of a single dose of TransCon GH as compared to equivalent doses of daily GH (Omnitrope) or placebo in healthy adults. Forty-four healthy male adults were randomized to 4 cohorts of 11 subjects, distributed in a 7:2:2 ratio (TransCon GH: Omnitrope: placebo)...
December 5, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29238631/ethnic-and-age-disparities-in-patients-taking-long-acting-injectable-atypical-antipsychotics
#20
Mateen Soleman, Nikki Lam, Benjamin K Woo
Introduction This study will determine whether different ethnicities and different age groups receive equal amounts of long-acting atypical antipsychotics in comparison to their oral equivalents. Methods Secondary analyses of data from the Los Angeles County Department of Health Services Electronic Health Record (total N=63,134 inpatient visits) were performed. Chi-squared statistics were used to compare ethnicity and age with the use of either risperidone injectable or paliperidone palmitate (r-LAIs) versus risperidone oral...
October 12, 2017: Curēus
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