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https://www.readbyqxmd.com/read/20889744/fliz-regulates-expression-of-the-salmonella-pathogenicity-island-1-invasion-locus-by-controlling-hild-protein-activity-in-salmonella-enterica-serovar-typhimurium
#1
Jessica E Cott Chubiz, Yekaterina A Golubeva, Dongxia Lin, Lucas D Miller, James M Slauch
A prerequisite for Salmonella enterica to cause both intestinal and systemic disease is the direct injection of effector proteins into host intestinal epithelial cells via a type three secretion system (T3SS); the T3SS genes are carried on Salmonella pathogenicity island 1 (SPI1). These effector proteins induce inflammatory diarrhea and bacterial invasion. Expression of the SPI1 T3SS is tightly regulated in response to environmental signals through a variety of global regulatory systems. We have previously shown that three AraC-like regulators, HilD, HilC, and RtsA, act in a complex feed-forward regulatory loop to control the expression of the hilA gene, which encodes the direct regulator of the SPI1 structural genes...
December 2010: Journal of Bacteriology
https://www.readbyqxmd.com/read/19509230/long-term-cultures-of-bone-marrow-derived-human-mesenchymal-stem-cells-frequently-undergo-spontaneous-malignant-transformation
#2
Gro Vatne Røsland, Agnete Svendsen, Anja Torsvik, Ewa Sobala, Emmet McCormack, Heike Immervoll, Josef Mysliwietz, Joerg-Christian Tonn, Roland Goldbrunner, Per Eystein Lønning, Rolf Bjerkvig, Christian Schichor
Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell-based therapies of tissue injury and degenerative diseases. However, extensive expansion ex vivo is a prerequisite to obtain the cell numbers required for human cell-based therapy protocols. Recent studies indicate that hMSC may contribute to cancer development and progression either by acting as cancer-initiating cells or through interactions with stromal elements...
July 1, 2009: Cancer Research
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