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Shagun Krishna, Sushil Kumar, Deependra Kumar Singh, Amar Deep Lakra, Dibyendu Banerjee, Mohammad Imran Siddiqi
The histone acetyl transferase (HAT) are involved in acetylation of histones that lead to transcription activation in numerous gene regulatory mechanisms. There are very few GCN5 HAT inhibitors reported despite of their role in cancer progression. In this study, we have utilized in-silico virtual screening approaches based on various machine learning algorithm to identify potent inhibitors of GCN5 HAT from commercially available Maybridge library. We have generated predictive chemoinformatics models based on k-Nearest neighbour, naïve Bayesian, Random Forest and Support Vector Machine...
April 23, 2018: Molecular Informatics
Chao Che, Zhaosheng Qian, Mingchang Wu, Ying Zhao, Gangguo Zhu
A novel silver-catalyzed ring-opening acylation of cyclopropanols and cyclobutanols is described. The reaction proceeds under mild and neutral conditions and provides a facile access to nonsymmetric 1,4- and 1,5-diketones in promising yields with broad substrate scope. Mechanistic studies including DFT calculations suggest the involvement of an uncommon water-assisted 1,2-HAT process, which is strongly exothermic and thus promotes addition of carbon radicals to aldehydes. In contrast to traditional reductive radical addition protocols, this work represents the first example on the intermolecular oxidative radical addition to aldehydes, thus offering a novel strategy for the direct synthesis of acyclic ketones from readily accessible aldehydes...
April 23, 2018: Journal of Organic Chemistry
C Backes, A Religi, L Moccozet, L Vuilleumier, D Vernez, J-L Bulliard
BACKGROUND/PURPOSE: Solar ultraviolet radiation (UVR) doses received by individuals are highly influenced by behavioural and environmental factors. This study aimed at quantifying hats' sun protection effectiveness in various exposure conditions, by predicting UVR exposure doses and their anatomical distributions. METHODS: A well-defined three-dimensional head morphology and four hat styles (a cap, a helmet, a middle- and a wide-brimmed hat) were added to a previously published model...
April 23, 2018: Photodermatology, Photoimmunology & Photomedicine
Reiofeli A Salas-Perez, Christopher A Saski, Rooksana E Noorai, Subodh K Srivastava, Amy L Lawton-Rauh, Robert L Nichols, Nilda Roma-Burgos
Amaranthus palmeri (Amaranthaceae) is a noxious weed in several agroecosystems and in some cases seriously threatens the sustainability of crop production in North America. Glyphosate-resistant Amaranthus species are widespread, prompting the use of alternatives to glyphosate such as glufosinate, in conjunction with glufosinate-resistant crop cultivars, to help control glyphosate-resistant weeds. An experiment was conducted to analyze the transcriptome of A. palmeri plants that survived exposure to 0.55 kg ha-1 glufosinate...
2018: PloS One
Michela Salamone, Vanesa B Ortega, Teo Martin, Massimo Bietti
A kinetic study on the reactions of the cumyloxyl radical (CumO•) with a series of alkanols and alkanediols has been carried out. Predominant HAT from the α-C-H bonds of these substrates, activated by the presence of the OH group, is observed. The comparable kH values measured for ethanol and 1-propanol and the increase in kH measured on going from 1,2-diols to structurally related 1,3- and 1,4-diols is indicative of β-C-H deactivation toward HAT to the electrophilic CumO• determined by the electron withdrawing character of the OH group...
April 18, 2018: Journal of Organic Chemistry
Stylianos Voulgarelis, Bernadette Vitola, Stacee M Lerret, Johnny C Hong, John P Scott
Despite continued advancements in perioperative care for pediatric liver transplant (LT), graft-threatening vascular occlusion events including hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) remain a source of significant morbidity and mortality. Perioperative anticoagulation is commonly used for the prevention of HAT and PVT, but evidence-based guidelines are lacking. The goals of this survey were to determine the frequency of use of an anticoagulation protocol and to describe variation in anticoagulation practices among pediatric LT centers...
April 16, 2018: Pediatric Transplantation
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No abstract text is available yet for this article.
April 2018: Journal of Food Science
Andrea Hornakova, Markus List, Jilles Vreeken, Marcel H Schulz
Motivation: Genome-wide measurements of paired miRNA and gene expression data have enabled the prediction of competing endogenous RNAs (ceRNAs). It has been shown hat the sponge effect mediated by protein-coding as well as non-coding ceRNAs can play an important regulatory role in the cell in health and disease. Therefore many computational methods for the computational identification of ceRNAs have been suggested. In particular methods based on Conditional Mutual Information (CMI) have shown promising results...
April 6, 2018: Bioinformatics
Paulina Natalia Kopa, Rafał Pawliczak
Cigarette smoke has an crucial impact on transcriptome alteration by its effect on chromatin remodeling and DNA methylation status. The first mechanism is associated with the histone acetylation/deacetylation balance damage as a result of increased activity of NFĸB and lipid peroxidation products, which lead to an increased activity of HATs and DNMTs and reduced HDACs. The second mechanism is connected with direct damaging of DNA by smoke components, activation of downstream repair mechanism and recruitment of DNMTs into the breakage site, "nicotine effect" and carbon monoxide activity on gene transcription and DNA methylation reduction...
April 16, 2018: Toxicology Mechanisms and Methods
Milena Frazer, Amy Ciarlo, Jill Herr, Carrie-Ellen Briere
OBJECTIVE: To decrease rates of admission hypothermia (<36 °C) in very-low-birth-weight (VLBW) newborns (<1,500 g). DESIGN: Quality improvement initiative. SETTING/LOCAL PROBLEM: Urban, Level IV NICU with 32 patient beds. The number of VLBW newborns admitted with temperatures less than 36 °C was greater than in comparable NICUs in the Vermont Oxford Network. PARTICIPANTS: Neonates born in 2016 who weighed less than 1,500 g at birth...
April 12, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
X Y Zeng, Y X Ye, X H Shi, Z Y Wang, K Deng, J Zhang, Z H Lu
Higher-order mode locking has been proposed to reduce the thermal noise limit of reference cavities. By locking a laser to the HG02 mode of a 10-cm long all ultra-low expansion (ULE) cavity and measuring its performance with the three-cornered-hat method among three independently stabilized lasers, we demonstrate a thermal-noise-limited performance of a fractional frequency instability of 4.9×10-16 . The results match the theoretical models with higher-order optical modes. The achieved laser instability improves the all ULE short cavity results to a new low level...
April 15, 2018: Optics Letters
Hideki Hayashi, Yoshinao Kubo, Mai Izumida, Etsuhisa Takahashi, Hiroshi Kido, Ko Sato, Mutsuo Yamaya, Hidekazu Nishimura, Kou Nakayama, Toshifumi Matsuyama
Cleavage and activation of hemagglutinin (HA) by trypsin-like proteases in influenza A virus (IAV) are essential prerequisites for its successful infection and spread. In host cells, some transmembrane serine proteases such as TMPRSS2, TMPRSS4 and HAT, along with plasmin in the bloodstream, have been reported to cleave the HA precursor (HA0 ) molecule into its active forms, HA1 and HA2 . Some trypsinogens can also enhance IAV proliferation in some cell types (e.g., rat cardiomyoblasts). However, the precise activation mechanism for this process is unclear, because the expression level of the physiological activator of the trypsinogens, the TMPRSS15 enterokinase, is expected to be very low in such cells, with the exception of duodenal cells...
2018: Frontiers in Cellular and Infection Microbiology
Brandon A Vara, Xingpin Li, Simon Berritt, Christopher R Walters, E James Petersson, Gary A Molander
Site-specific functionalization of unprotected native peptides and biomolecules remains a useful transformation in synthetic design and chemical biology, yet until recently, advancements in transition metal-catalyzed methods, which have prevailed in organic synthesis, have been relatively ineffective when applied to large and structurally complex biomolecules. Here, the mechanistically distinct, Ni/photoredox-catalyzed arylation of unprotected, native thiols ( e.g. , cysteine residues) is reported - a process initiated through a visible light-promoted, hydrogen atom transfer (HAT) event under ambient conditions...
January 14, 2018: Chemical Science
Francesco Checchi, Sebastian Funk, Daniel Chandramohan, François Chappuis, Daniel T Haydon
Gambiense Human African Trypanosomiasis (HAT), or sleeping sickness, is a vector-borne disease affecting largely rural populations in Western and Central Africa. The main method for detecting and treating cases of gambiense HAT are active screening through mobile teams and passive detection through self-referral of patients to dedicated treatment centres or hospitals. Strategies based on active case finding and treatment have drastically reduced the global incidence of the disease over recent decades. However, little is known about the coverage and transmission impact of passive case detection...
April 6, 2018: PLoS Neglected Tropical Diseases
Bei-Ping Miao, Rui-Shi Zhang, Gui Yang, Jin-Jie Sun, Yu-Yan Tang, Wei-Feng Liang, Tao Liu, Zhong Wen, Ping-Chang Yang, Guo-Hui Nie
The deregulation of Bcl2L12 expression in cancer has been recognized, but the causative factors are unknown. Histone acetyltransferases (HAT) play critical roles in the regulation gene transcription. This study tests a hypothesis that the aberrant activities of HAT induce deregulation of Bcl2L12 in nasopharyngeal cancer (NPC). In this study, human NPC tissues were collected from the clinic. The expression of Bcl2L12 and HATs in NPC cells was analyzed by real time RT-PCR and Western blotting. NPC cell apoptosis was analyzed by flow cytometry...
April 2, 2018: Archives of Biochemistry and Biophysics
Ana Filipa Duarte, António Picoto, Altamiro da Costa Pereira, Osvaldo Correia
BACKGROUND: Incidence of skin cancer is increasing worldwide and UV exposure at a young age is an important risk factor. OBJECTIVES: To compare sun exposure-related knowledge and behaviour among children during school and holiday periods. Material &Methods: A cross-sectional study was undertaken at 12 Oporto public primary schools. Educational sessions for educators were head by dermatologists every spring from 2004 to 2012. An educational activity book, Play and Learn with Jo Spots, was distributed to all primary school children and was explained by the educators every year...
April 5, 2018: European Journal of Dermatology: EJD
Yating Zhao, Wujiong Xia
The employment of nitrogen sources with free N-H bonds for amination is considered to be most straightforward and desirable, especially when the C-N bonds are prepared from N-H bonds and non-functionalized carbon sources, such as C-H bonds and C-C double/triple bonds, since this obviates the needs for the pre-installation of reactive groups in the starting materials and leads to a high atom and step economy. Recently, radical chemistry has been resuscitated owing to its great value in organic synthesis, and notable advances have been made in the direct use of N-H bonds for radical-based C-N bond formation with photo-/electrotechniques...
April 5, 2018: Chemical Society Reviews
Shubhanshu Gupta, Anil K Malhotra, Santosh K Verma, Rashmi Yadav
Context: Occupational injuries constitute a global health challenge, yet they receive comparatively modest scientific attention. Pattern of occupational injuries and its safety precautions among wagon repair workers is an important health issue, especially in developing countries like India. Aims: To assess the pattern of occupational injuries and utilization of safety measures among railway wagon repair workshop workers in Jhansi (U.P.). Settings and Design: Railway wagon repair workshop urban area, Jhansi (U...
September 2017: Indian Journal of Occupational and Environmental Medicine
Christopher J Rowlands, Florian Ströhl, Pedro P Vallejo Ramirez, Katharina M Scherer, Clemens F Kaminski
Super-resolution single-molecule localization microscopy, often referred to as PALM/STORM, works by ensuring that fewer than one fluorophore in a diffraction-limited volume is emitting at any one time, allowing the observer to infer that the emitter is located at the center of the point-spread function. This requires careful control over the incident light intensity in order to control the rate at which fluorophores are switched on; if too many fluorophores are activated, their point-spread functions overlap, which impedes efficient localization...
April 4, 2018: Scientific Reports
Shu Kwun Lui, Catherine R Garcia, Xiaonan Mei, Roberto Gedaly
BACKGROUND: Hepatic artery thrombosis (HAT) is a major complication after liver transplantation that commonly requires re-transplantation. METHODS: We queried the UNOS dataset for all patients transplanted between 1995 and 2015 for HAT. RESULTS: We identified 623 patients who underwent re-transplantation for HAT with a mean age of 51.25 + 10.4 years. The mean BMI was 26.72 kg/m2 , and mean MELD score was 19.62 + 9.09. There was a higher proportion of male patients, with higher prevalence of pre-transplant portal vein thrombosis (7...
April 3, 2018: World Journal of Surgery
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