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https://www.readbyqxmd.com/read/28214321/pr%C3%A3-und-perioperative-aspekte-der-versorgung-dermatochirurgischer-patienten
#1
Cornelia S L Müller, Wakiko Hubner, Sigrid Thieme-Ruffing, Claudia Pföhler, Thomas Vogt, Thomas Volk, Barbara C Gärtner, Patric Bialas
Die Dermatochirurgie nimmt hinsichtlich vieler Punkte eine Sonderstellung unter den operativen Fächern ein. Hierzu gehört in erster Linie die Tatsache, dass bis auf wenige Ausnahmen fast alle Eingriffe traditionell in Lokal- bzw. Regionalanästhesie und oft auch in räumlich-infrastruktureller Trennung von den großen Zentral-Operationssälen stattfinden können. Die peri- und postoperative Überwachung obliegt dabei dem dermatochirurgischen Operationsteam. Das sui generis kleinere OP-Team hat somit eine ganze Reihe perioperativer Notwendigkeiten zu beachten, um die sich in den "großen" chirurgischen Fächern eine Vielzahl verschiedener beteiligter Fachgruppen gemeinsam kümmern...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28210488/systematic-distortions-in-vertical-placement-of-features-in-drawings-of-faces-and-houses
#2
Neil R Harrison, Julia Jones, Simon J Davies
A crucial part of accurately drawing portraits is the correct vertical positioning of the eyes. Non-experts typically place the eyes higher on the head than they are actually located; however, the explanation for this remains unclear. In Experiment 1, participants drew faces from memory and directly copied from a photograph, to confirm whether biases in observational drawings were related to biases in memory-based drawings. In Experiment 2, participants drew a cat's face, to test explanations by Carbon and Wirth for the positional bias: the 'view-from-below, the 'head-as-box', and the 'hair-as-hat' explanations...
January 2017: I-Perception
https://www.readbyqxmd.com/read/28210000/high-velocity-deformation-of-al0-3cocrfeni-high-entropy-alloy-remarkable-resistance-to-shear-failure
#3
Z Li, S Zhao, H Diao, P K Liaw, M A Meyers
The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening rate, which is significantly larger than that for Al and is retained in the dynamic regime. The resistance to shear localization was studied by dynamically-loading hat-shaped specimens to induce forced shear localization...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209508/systematic-review-of-measures-of-impairment-and-activity-limitation-for-person-with-upper-limb-trauma-and-amputation
#4
REVIEW
Linda Resnik, Matt Borgia, Ben Silver, Jill Cancio
OBJECTIVE: Study purposes were to 1) identify outcome measures used in studies of persons with traumatic upper limb injury and/or amputation and 2) evaluate focus, content and psychometric properties of each measure. DATA SOURCES: Searches of PubMed and CINAHL for terms including upper extremity, function, activities of daily living, outcome assessment, amputation and traumatic injuries. STUDY SELECTION: Included articles had a sample of ≥10 adults with limb trauma or amputation, and were in English...
February 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28204924/genome-wide-analysis-of-transposable-elements-in-the-coffee-berry-borer-hypothenemus-hampei-coleoptera-curculionidae-description-of-novel-families
#5
Eric M Hernandez-Hernandez, Rita Daniela Fernández-Medina, Lucio Navarro-Escalante, Jonathan Nuñez, Pablo Benavides-Machado, Claudia M A Carareto
The coffee berry borer (CBB) Hypothenemus hampei is the most limiting pest of coffee production worldwide. The CBB genome has been recently sequenced; however, information regarding the presence and characteristics of transposable elements (TEs) was not provided. Using systematic searching strategies based on both de novo and homology-based approaches, we present a library of TEs from the draft genome of CBB sequenced by the Colombian Coffee Growers Federation. The library consists of 880 sequences classified as 66% Class I (LTRs: 46%, non-LTRs: 20%) and 34% Class II (DNA transposons: 8%, Helitrons: 16% and MITEs: 10%) elements, including families of the three main LTR (Gypsy, Bel-Pao and Copia) and non-LTR (CR1, Daphne, I/Nimb, Jockey, Kiri, R1, R2 and R4) clades and DNA superfamilies (Tc1-mariner, hAT, Merlin, P, PIF-Harbinger, PiggyBac and Helitron)...
February 15, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28202522/histone-acetyltransferase-activity-of-mof-is-required-for-mll-af9-leukemogenesis
#6
Daria G Valerio, Haiming Xu, Chun-Wei Chen, Takayuki Hoshii, Meghan E Eisold, Christopher Delaney, Monica Cusan, Aniruddha J Deshpande, Chun-Hao Huang, Amaia Lujambio, Y George G Zheng, Johannes Zuber, Tej K Pandita, Scott W Lowe, Scott A Armstrong
Chromatin-based mechanisms offer therapeutic targets in acute myeloid leukemia (AML) that are of great current interest. In this study, we conducted an RNAi-based screen to identify druggable chromatin regulator-based targets in leukemias marked by oncogenic rearrangements of the MLL gene. In this manner, we discovered the H4K16 histone acetyltransferase (HAT) MOF to be a potent suppressor of leukemia cell growth. Conditional deletion of Mof in a mouse model of MLL-AF9-driven leukemogenesis reduced tumor burden and prolonged host survival...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28194469/phenylephrine-induced-cardiac-hypertrophy-is-attenuated-by-a-histone-acetylase-inhibitor-anacardic-acid-in-mice
#7
Chang Peng, Xiaomei Luo, Shuo Li, Huichao Sun
Cardiac hypertrophy is a complex process involving highly coordinated but tight regulation of multiple elements, such as in epigenetics, which make an important contribution to myocardium remodeling and cardiac hypertrophy. Epigenetic regulations, particularly histone acetylation, have been implicated in cardiac hypertrophy, however, the exact mechanism is still largely unknown. In the present study, we explored the potential attenuating effects of Chinese herbal extract anacardic acid on phenylephrine-induced cardiac hypertrophy and the underlying mechanism...
February 14, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28194219/development-of-a-lecithotrophic-pilidium-larva-illustrates-convergent-evolution-of-trochophore-like-morphology
#8
Marie K Hunt, Svetlana A Maslakova
BACKGROUND: The pilidium larva is an idiosyncrasy defining one clade of marine invertebrates, the Pilidiophora (Nemertea, Spiralia). Uniquely, in pilidial development, the juvenile worm forms from a series of isolated rudiments called imaginal discs, then erupts through and devours the larval body during catastrophic metamorphosis. A typical pilidium is planktotrophic and looks like a hat with earflaps, but pilidial diversity is much broader and includes several types of non-feeding pilidia...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28192940/analysis-of-tertiary-interactions-between-sart3-and-u6-small-nuclear-rna-using-modified-nanocapillaries
#9
Choongman Lee, Joon Kyu Park, Yeoan Youn, Joo Hyoung Kim, Kyo-Seok Lee, Nak-Kyoon Kim, Eunji Kim, Eunice Eunkyeong Kim, Kyung-Hwa Yoo
We employed modified glass nanocapillaries to investigate interactions between the RNA-binding protein, known as cell carcinoma antigen recognized by T cells-3 (SART3), and the noncoding spliceosome component, U6 small nuclear RNA (snRNA), at the single-molecule level. We functionalized the nanocapillaries with U6 snRNA fragments, which were hybridized to DNA molecules and then covalently attached to the nanocapillary surface. When transported through the modified nanocapillaries, two different SART3-derived constructs, HAT-RRM1-RRM2 and RRM1-RRM2, exhibited resistive ionic current pulses with different dwell times, which represented their different binding affinities to tethered U6 snRNAs...
February 9, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191974/single-molecule-fluorescence-spectroscopy-of-perylene-diimide-dyes-in-a-%C3%AE-cyclodextrin-film-manifestation-of-photoinduced-h-atom-transfer-via-higher-triplet-n-%C3%AF-excited-states
#10
Masaaki Mitsui, Hiroki Fukui, Ryoya Takahashi, Yasushi Takakura, Toshinari Mizukami
Supramolecular complexation of γ-cyclodextrin (γ-CD) with N,N'-bis(2,6-dimethylphenyl)perylene-3,4,9,10-tetracarboxylic diimide (DMP-PDI) or N,N'-bis(2,6-dioctyl)perylene-3,4,9,10-tetracarboxylic diimide (C8-PDI) dye in an aqueous solution and in a γ-CD solid film were investigated via ensemble and single-molecule fluorescence spectroscopy. These two perylene diimide derivatives possess almost the same electronic structure but have different terminal functional groups. This structural difference leads to formation of an inclusion complex of γ-CD with DMP-PDI but not with C8-PDI in aqueous solution...
February 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28189085/synthesis-and-antitrypanosomal-activities-of-novel-pyridylchalcones
#11
Avninder S Bhambra, Ketan C Ruparelia, Hoon L Tan, Deniz Tasdemir, Hollie Burrell-Saward, Vanessa Yardley, Kenneth J M Beresford, Randolph R J Arroo
A library of novel pyridylchalcones were synthesised and screened against Trypanosoma brucei rhodesiense. Eight were shown to have good activity with the most potent 8 having an IC50 value of 0.29 μM. Cytotoxicity testing with human KB cells showed a good selectivity profile for this compound with a selectivity index of 47. Little activity was seen when the library was tested against Leishmania donovani. In conclusion, pyridylchalcones are promising leads in the development of novel compounds for the treatment of human African trypanosomiasis (HAT)...
January 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28187957/discovery-of-n-2-aminoethyl-n-benzyloxyphenyl-benzamides-new-potent-trypanosoma-brucei-inhibitors
#12
Andriy Buchynskyy, J Robert Gillespie, Matthew A Hulverson, Joshua McQueen, Sharon A Creason, Ranae M Ranade, Nicole A Duster, Michael H Gelb, Frederick S Buckner
A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), led to the identification of N-(2-aminoethyl)-N-phenyl benzamides as a starting point for hit-to-lead medicinal chemistry. Eighty two analogues were prepared, which led to the identification of a set of highly potent N-(2-aminoethyl)-N-benzyloxyphenyl benzamides with the most potent compound 73 having an in vitro EC50=0.001μM. The compounds displayed drug-like properties when tested in a number of in vitro assays...
November 12, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28187447/egr-1-and-rna-pol-ii-facilitate-glioma-cell-gdnf-transcription-induced-by-histone-hyperacetylation-in-promoter-ii
#13
Bao-Le Zhang, Ting-Wen Guo, Le-Le Gao, Guang-Quan Ji, Xiao-He Gu, Yu-Qi Shao, Rui-Qin Yao, Dian-Shuai Gao
The specific mechanisms for epigenetic regulation of gene transcription remain to be elucidated. We previously demonstrated that hyperacetylation of histone H3K9 in promoter II of glioma cells promotes high transcription of the glial cell line-derived neurotrophic factor (GDNF) gene. This hyperacetylation significantly enhanced Egr-1 binding and increased the recruitment of RNA polymerase II (RNA POL II) to that region (P < 0.05). Egr-1 expression was abnormally increased in C6 glioma cells. Further overexpression of Egr-1 significantly increased Egr-1 binding to GDNF promoter II, while increasing RNA POL II recruitment, thus increasing GDNF transcription (P < 0...
February 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28176583/reducing-mental-health-stigma-is-not-enough
#14
Ian Hulatt
Ministerial announcements have become a bit predictable - an MP will don a hard hat and a high-vis jacket and surround themselves with some baffled-looking workers at a building site while they introduce a new initiative.
February 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28175968/augmentation-of-the-nipples-reconstructed-with-modified-top-hat-flap-using-dermal-grafts-in-implant-based-breast-reconstruction-a-comparative-study
#15
Hoon Kim, Sang Il Kim, Won Ha, Chi Sun Yoon, Taik Jong Lee, Kyu Nam Kim
BACKGROUND: Nipple reconstruction in implant-based breast reconstruction remains challenging, as the remaining thin skin envelope results in a less projected neo-nipple with a reduced volume. This study presents a modified top-hat flap technique with rolled dermal grafts from the dog-ears of lateral wings for augmenting reconstructed nipples during implant-based breast reconstruction. METHODS: Between April 2011 and December 2014, among 34 patients who underwent immediate post-mastectomy reconstruction with a direct silicone implant, nipple reconstruction was performed using the modified top-hat flap technique in only 21 patients (group A), whereas 13 patients underwent the modified top-hat flap technique with rolled dermal grafts from the dog-ears of lateral wings (group B)...
February 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28169286/garcinol-blocks-the-reconsolidation-of-multiple-cocaine-paired-cues-after-a-single-cocaine-reactivation-session
#16
Amber B Dunbar, Jane R Taylor
Manipulations of memory reconsolidation can interfere with the ability of a drug-paired cue to drive drug-seeking behavior. However, the typical reconsolidation paradigm that reactivates the memory through the presentation of the cue (conditioned stimulus; CS) only interferes with the memory of the reactivated CS while leaving other drug-paired CSs intact and able to continue driving drug-seeking behavior. Here, we used a novel unconditioned-stimulus (US) reactivation paradigm to interfere with the ability of multiple cues to drive drug-seeking behavior after just one reactivation and treatment session...
February 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28165516/the-degradation-mechanism-of-sulfamethoxazole-under-ozonation-a-dft-study
#17
Hang Yu, Pu Ge, Jingwen Chen, Hongbin Xie, Yi Luo
Sulfamethoxazole (SMX), a kind of antibiotic, remains in the environment and threatens public health. Ozone as a strong and green oxidant was widely used for selective oxidation degradation of residual SMX. However, it is hard to elucidate the detailed oxidation mechanism through current experimental approaches. A theoretical study has been carried out herein for exploring possible ozonation pathways of SMX. Two reaction mechanisms, viz., direct addition (DA) and H atom transfer (HAT), are considered. The results show that the primary oxidation of aromatic rings (benzene or isoxazole rings) of SMX follows the DA mechanism, featuring an electrophilic addition...
February 6, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28162093/evaluating-the-impact-of-targeting-livestock-for-the-prevention-of-human-and-animal-trypanosomiasis-at-village-level-in-districts-newly-affected-with-t-b-rhodesiense-in-uganda
#18
Louise Hamill, Kim Picozzi, Jenna Fyfe, Beatrix von Wissmann, Sally Wastling, Nicola Wardrop, Richard Selby, Christine Amongi Acup, Kevin L Bardosh, Dennis Muhanguzi, John D Kabasa, Charles Waiswa, Susan C Welburn
BACKGROUND: Uganda has suffered from a series of epidemics of Human African Trypanosomiasis (HAT), a tsetse transmitted disease, also known as sleeping sickness. The area affected by acute Trypanosoma brucei rhodesiense HAT (rHAT) has been expanding, driven by importation of infected cattle into regions previously free of the disease. These regions are also affected by African Animal Trypanosomiasis (AAT) demanding a strategy for integrated disease control. METHODS: In 2008, the Public Private Partnership, Stamp Out Sleeping Sickness (SOS) administered a single dose of trypanocide to 31 486 head of cattle in 29 parishes in Dokolo and Kaberamaido districts...
February 6, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28157211/platelet-activating-factor-induced-expression-of-p21-is-correlated-with-histone-acetylation
#19
Elisabetta Damiani, Nahum Puebla-Osorio, Bree M Lege, Jingwei Liu, Sattva S Neelapu, Stephen E Ullrich
Ultraviolet (UV)-irradiated keratinocytes secrete the lipid mediator of inflammation, platelet-activating factor (PAF). PAF plays an essential role in UV-induced immune suppression and skin cancer induction. Dermal mast cell migration from the skin to the draining lymph nodes plays a prominent role in activating systemic immune suppression. UV-induced PAF activates mast cell migration by up-regulating mast cell CXCR4 surface expression. Recent findings indicate that PAF up-regulates CXCR4 expression via histone acetylation...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28154333/structural-and-biochemical-analyses-on-the-rna-dependent-rna-polymerase-of-influenza-virus-for-development-of-novel-anti-influenza-agents
#20
Dai Hatakeyama
 The PA, PB1, and PB2 subunits, components of the RNA-dependent RNA polymerase of influenza A virus, and the nucleoprotein (NP) interact with the genomic RNA of influenza viruses and form ribonucleoproteins. Especially, the PB2 subunit binds to the host RNA cap [7-methylguanosine triphosphate (m(7)GTP)] and supports the endonuclease activity of PA to "snatch" the cap from host pre-mRNAs. In this study, we describe a novel Val/Arg/Gly (VRG) site in the PB2 cap-binding domain, which is necessary for interaction with acetyl-CoA found in eukaryotic histone acetyltransferases (HATs)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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