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https://www.readbyqxmd.com/read/28637278/functional-and-structural-analysis-of-at-specific-minor-groove-binders-that-disrupt-dna-protein-interactions-and-cause-disintegration-of-the-trypanosoma-brucei-kinetoplast
#1
Cinthia R Millan, Francisco J Acosta-Reyes, Laura Lagartera, Godwin U Ebiloma, Leandro Lemgruber, J Jonathan Nué Martínez, Núria Saperas, Christophe Dardonville, Harry P de Koning, J Lourdes Campos
Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of drugs interacting with AT-rich DNA, such as the N-phenylbenzamide bis(2-aminoimidazoline) derivatives 1 [4-((4,5-dihydro-1H-imidazol-2-yl)amino)-N-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzamide dihydrochloride] and 2 [N-(3-chloro-4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)-4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzamide] as potential drugs for HAT...
June 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28631104/is-there-an-association-between-surgeon-hat-type-and-30-day-wound-events-following-ventral-hernia-repair
#2
REVIEW
I N Haskins, A S Prabhu, D M Krpata, A J Perez, L Tastaldi, C Tu, S Rosenblatt, B K Poulose, M J Rosen
INTRODUCTION: While several patient and operative variables have been shown to be associated with an increased risk of postoperative wound events, the association between surgical hat type worn by surgeons and postoperative wound events remains controversial. The purpose of this study is to investigate the association between type of surgical hat worn by surgeons and the incidence of postoperative wound events following ventral hernia repair using the Americas Hernia Society Quality Collaborative database...
June 19, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28630323/role-of-the-cbp-catalytic-core-in-intramolecular-sumoylation-and-control-of-histone-h3-acetylation
#3
Sangho Park, Robyn L Stanfield, Maria A Martinez-Yamout, H Jane Dyson, Ian A Wilson, Peter E Wright
The histone acetyl transferases CREB-binding protein (CBP) and its paralog p300 play a critical role in numerous cellular processes. Dysregulation of their catalytic activity is associated with several human diseases. Previous work has elucidated the regulatory mechanisms of p300 acetyltransferase activity, but it is not known whether CBP activity is controlled similarly. Here, we present the crystal structure of the CBP catalytic core encompassing the bromodomain (BRD), CH2 (comprising PHD and RING), HAT, and ZZ domains at 2...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28623334/novel-complex-of-hat-protein-tip60-and-nuclear-receptor-pxr-promotes-cell-migration-and-adhesion
#4
Karishma Bakshi, B Ranjitha, Shraddha Dubey, Jaisri Jagannadham, Bharti Jaiswal, Ashish Gupta
PXR is a member of nuclear receptor superfamily and a well-characterized mediator of xenobiotic metabolism. The classical mode of PXR activation involves its binding to appropriate ligand and subsequent heterodimerization with its partner RXR. However, various factors such as post-translational modifications and crosstalk with different cellular factors may also regulate the functional dynamics and behavior of PXR. In the present study, we have identified that TIP60, an essential lysine acetyltransferase protein interacts with unliganded PXR and together this complex promotes cell migration & adhesion...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621875/retransplantation-after-a-failed-donation-after-circulatory-determination-of-death-liver-transplant-meld-exception-priority-and-second-chances
#5
EDITORIAL
Peter L Abt, David S Goldberg
Increased utilization of higher-risk liver allografts is hampered by concerns about an increased risk of post-transplant graft failure and subsequent death if the patient is not retransplanted. This dilemma faces clinicians considering broader use of livers from donation after circulatory determination of death (DCDD) donors. In the setting of primary non-function or early hepatic artery thrombosis (HAT), there is a mechanism for standardized awarding of Model for End-Stage Liver Disease (MELD) exception points...
June 16, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28620357/the-effectiveness-of-nitrate-mediated-control-of-the-oil-field-sulfur-cycle-depends-on-the-toluene-content-of-the-oil
#6
Navreet Suri, Johanna Voordouw, Gerrit Voordouw
The injection of nitrate is one of the most commonly used technologies to impact the sulfur cycle in subsurface oil fields. Nitrate injection enhances the activity of nitrate-reducing bacteria, which produce nitrite inhibiting sulfate-reducing bacteria (SRB). Subsequent reduction of nitrate to di-nitrogen (N2) alleviates the inhibition of SRB by nitrite. It has been shown for the Medicine Hat Glauconitic C (MHGC) field, that alkylbenzenes especially toluene are important electron donors for the reduction of nitrate to nitrite and N2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28618800/effects-of-tempo-swing-density-and-listener-s-drumming-experience-on-swing-detection-thresholds-for-drum-rhythms
#7
Andrew V Frane, Ladan Shams
Swing, a popular technique in music performance, has been said to enhance the "groove" of the rhythm. Swing works by delaying the onsets of even-numbered subdivisions of each beat (e.g., 16th-note swing delays the onsets of the second and fourth 16th-note subdivisions of each quarter-note beat). The "swing magnitude" (loosely speaking, the amount of delay) is often quite small. And there has been little investigation, using musical stimuli, into what swing magnitudes listeners can detect. To that end, this study presented continually-looped electronic drum rhythms, with 16th-note swing in the hi-hat on every other bar, to drummers and non-drummers...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28615879/the-eggshell-morphology-of-rallicola-unguiculatus-piaget-1880-ischnocera-phthiraptera
#8
Aftab Ahmad
The egg chorion of the greater coucal louse, Rallicola unguiculatus bears hexagonal ridges. The hat shaped opercular disc also shows hexagonal marks. Twenty to twenty-three button shaped micropyles occur along the opercular rim. The stigma remained obscured under the cementing material.
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28612427/simulation-based-investigation-of-deleterious-nssnp-s-in-atxn2-gene-and-its-structural-consequence-towards-spinocerebellar-ataxia
#9
Siddharth Sinha, Sharad Verma, Aditi Singh, Pallavi Somvanshi, Abhinav Grover
Spinocerebellar degeneration, termed as ataxia is a neurological disorder of central nervous system, characterized by limb in-coordination and a progressive gait. The patient also demonstrates specific symptoms of muscle weakness, slurring of speech, and decreased vibration senses. Expansion of polyglutamine trinucleotide (CAG) within ATXN2 gene with 35 or more repeats, results in spinocerebellar ataxia type-2. Protein ataxin-2 coded by ATXN2 gene has been reported to have a crucial role in translation of the genetic information through sequestering the histone acetyl transferases (HAT) resulting in a state of hypo-acetylation...
June 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28611753/differential-survival-of-hyper-aerotolerant-campylobacter-jejuni-under-different-gas-conditions
#10
Euna Oh, Lynn M McMullen, Linda Chui, Byeonghwa Jeon
Campylobacter jejuni accounts for a significant number of foodborne illnesses around the world. C. jejuni is microaerophilic and typically does not survive efficiently in oxygen-rich conditions. We recently reported that hyper-aerotolerant (HAT) C. jejuni are highly prevalent in retail poultry meat. To assess the capabilities of HAT C. jejuni in foodborne transmission and infection, in this study, we investigated the prevalence of virulence genes in HAT C. jejuni and the survival in poultry meat in atmosphere at a refrigeration temperature...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28610742/interventional-treatment-for-hepatic-artery-thrombosis-after-liver-transplantation
#11
Hua Zhang, Sheng Qian, Rong Liu, Wei Yuan, Jian-Hua Wang
PURPOSE: To evaluate short-term and long-term effectiveness of interventional treatment for hepatic artery thrombosis (HAT). MATERIALS AND METHODS: From March 2003 to October 2015, 34 patients (32 male and 2 female; mean age, 45 y; range 7-64 y) with HAT were identified 0-21d (mean 6.5 d ± 6.0) after liver transplantation and underwent interventional treatments. Technical success, clinical success, complications, hepatic artery patency, and survival time were assessed...
June 11, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28607956/a-wavelet-based-gaussian-method-for-energy-dispersive-x-ray-fluorescence-spectrum
#12
Pan Liu, Xiaoyan Deng, Xin Tang, Shijian Shen
This paper presents a wavelet-based Gaussian method (WGM) for the peak intensity estimation of energy dispersive X-ray fluorescence (EDXRF). The relationship between the parameters of Gaussian curve and the wavelet coefficients of Gaussian peak point is firstly established based on the Mexican hat wavelet. It is found that the Gaussian parameters can be accurately calculated by any two wavelet coefficients at the peak point which has to be known. This fact leads to a local Gaussian estimation method for spectral peaks, which estimates the Gaussian parameters based on the detail wavelet coefficients of Gaussian peak point...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28602812/impact-of-hypoglycaemia-on-patient-reported-outcomes-from-a-global-24-country-study-of-27-585-people-with-type-1-and-insulin-treated-type-2-diabetes
#13
Kamlesh Khunti, Saud Alsifri, Ronnie Aronson, Maja Cigrovski Berković, Catherine Enters-Weijnen, Tom Forsén, Gagik Galstyan, Petronella Geelhoed-Duijvestijn, Margalit Goldfracht, Helge Gydesen, Rahul Kapur, Nebojsa Lalic, Bernhard Ludvik, Erik Moberg, Ulrik Pedersen-Bjergaard, Ambady Ramachandran
AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countries, are lacking. The aim of this study was to assess fear of, and responses to, hypoglycaemia experienced by patients globally. MATERIALS AND METHODS: This non-interventional, multicentre, 4-week prospective study using self-assessment questionnaires and patient diaries consisted of 27,585 patients, ≥18years, with type 1 diabetes (n=8022) or type 2 diabetes (n=19,563) treated with insulin for >12months, at 2004 sites in 24 countries worldwide...
May 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28598457/rural-health-care-workers-and-local-residents-health-status-in-yulong-county-of-yunnan-province-china-and-hat-yai-city-of-songkhla-mansion-thailand
#14
Q U Fanwei, J Yanling, V Chongsuvivatwong, T Liabsuetrakul, L Yan, C Le, J Runsheng
INTRODUCTION: To compare health status between Hat Yai city of Songkhla Province in Thailand and Yulong county of Yunnan province in China about rural health care workers and local residents, analyzing of both differences, learning from the advanced experience and practice of Thailand, adjusting policy, especially for the implementation of measures to improve the lack of human resources construction of Yulong County rural health, promote the level of rural health service of Lijiang. METHODS: A qualitative study consisting of focus group discussions and individual in-depth interviews were conducted in Rural Health Care Workers and Local Residents Health Status in Yulong County of Yunnan Province China and Hat Yai City of Songkhla Mansion Thailand from...
January 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28598055/the-mexican-hat-sign-in-osmotic-demyelination-syndrome
#15
Lulup Kumar Sahoo, Ashok Kumar Mallick, Kali Prasanna Swain, Geeta Mohanty, Maheswar Samanta, Bijay Kumar Mohanty
No abstract text is available yet for this article.
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28596772/epigenetic-regulation-of-matrix-metalloproteinase-1-and-3-expression-in-mycobacterium-tuberculosis-infection
#16
Rachel C Moores, Sara Brilha, Frans Schutgens, Paul T Elkington, Jon S Friedland
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality. Matrix metalloproteinase (MMP)-1 is a host enzyme critical for the development of cavitation. MMP expression has been shown to be epigenetically regulated in other inflammatory diseases, but the importance of such mechanisms in Mtb-associated induction of MMP-1 is unknown. We investigated the role of changes in histone acetylation in Mtb-induced MMP expression using inhibitors of histone deacetylases (HDACs) and histone acetyltransferases (HAT), HDAC siRNA, promoter-reporter constructs, and chromatin immunoprecipitation assays...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28596418/err%C3%AE-maintains-mitochondrial-oxidative-metabolism-and-constitutes-an-actionable-target-in-pgc1%C3%AE-elevated-melanomas
#17
Pere Puigserver, Chi Luo, Eduardo Balsa, Ajith Thomas, Maximilian Hatting, Mark Jedrychowski, Steven P Gygi, Hans R Widlund
The uncontrolled growth of tumors provides metabolic dependencies that can be harnessed for therapeutic benefit. Although tumor cells exhibit these increased metabolic demands due to their rapid proliferation, these metabolic processes are general to all cells, and furthermore, targeted therapeutic intervention can provoke compensatory adaptation that alters tumors' characteristics. As an example, a subset of melanomas depends on the transcriptional coactivator PGC1α function to sustain their mitochondrial energy-dependent survival...
June 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28594263/phototrophy-and-starvation-based-induction-of-autophagy-upon-removal-of-gcn5-catalyzed-acetylation-of-atg7-in-magnaporthe-oryzae
#18
Shulin Zhang, Meiling Liang, Naweed Naqvi, Chaoxiang Lin, Wanqiang Qian, Lian-Hui Zhang, Yi Zhen Deng
Magnaporthe oryzae, the ascomycete fungus that causes rice blast disease, initiates conidiation in response to light when grown on Prune-Agar medium containing both carbon and nitrogen sources. Macroautophagy/autophagy was shown to be essential for M. oryzae conidiation and induced specifically upon exposure to light but is undetectable in the dark. Therefore, it is inferred that autophagy is naturally induced by light, rather than by starvation during M. oryzae conidiation. However, the signaling pathway(s) involved in such phototropic induction of autophagy remains unknown...
June 8, 2017: Autophagy
https://www.readbyqxmd.com/read/28592796/immunochemical-approach-for-monitoring-of-structural-transition-of-apoa-i-upon-hdl-formation-using-novel-monoclonal-antibodies
#19
Hitoshi Kimura, Shiho Mikawa, Chiharu Mizuguchi, Yuki Horie, Izumi Morita, Hiroyuki Oyama, Takashi Ohgita, Kazuchika Nishitsuji, Atsuko Takeuchi, Sissel Lund-Katz, Kenichi Akaji, Norihiro Kobayashi, Hiroyuki Saito
Apolipoprotein A-I (apoA-I) undergoes a large conformational reorganization during remodeling of high-density lipoprotein (HDL) particles. To detect structural transition of apoA-I upon HDL formation, we developed novel monoclonal antibodies (mAbs). Splenocytes from BALB/c mice immunized with a recombinant human apoA-I, with or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-1 myeloma cells. After the HAT-selection and cloning, we established nine hybridoma clones secreting anti-apoA-I mAbs in which four mAbs recognize epitopes on the N-terminal half of apoA-I while the other five mAbs recognize the central region...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590590/repurposing-of-human-kinase-inhibitors-in-neglected-protozoan-diseases
#20
Maria Dichiara, Agostino Marrazzo, Orazio Prezzavento, Simona Collina, Antonio Rescifina, Emanuele Amata
Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, belong to a group of infectious diseases defined as neglected tropical diseases, induced by infection with protozoan parasites named trypanosomatids. Current drugs present several issues and the development of new candidates appears to be needed. The majority of the current therapeutic trypanosomatid targets are represented by enzymes or cell surface receptors. Among these, eukaryotic protein kinases represent a major group of protein targets whose modulation may be beneficial for the treatment of neglected tropical protozoan diseases...
June 7, 2017: ChemMedChem
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