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https://www.readbyqxmd.com/read/28430222/impact-of-partial-coherence-on-the-apparent-optical-transfer-function-derived-from-the-response-to-amplitude-edges
#1
S Mojtaba Shakeri, Lucas J van Vliet, Sjoerd Stallinga
We present an investigation of the impact of partial coherence on optical imaging systems with the focus on whole slide imaging (WSI) systems for digital pathology. The investigation is based on the analysis of the edge response of the optical system, which gives rise to an apparent optical transfer function (OTF) that can be linked to two elementary complex functions Q and U. The function Q is directly related to the transmission cross coefficient (TCC) and can be identified with the performance function first introduced by Kintner and Sillitto...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28429040/retraction-force-necessary-to-expose-the-mandibular-neck-in-risdon-and-high-cervical-anteroparotid-transmasseteric-approaches-an-anatomic-comparative-study
#2
Jérôme Adnot, Aliosha Feuss, Fabrice Duparc, Olivier Trost
PURPOSE: The purpose of this anatomic study was to compare the retraction force necessary to expose the mandibular neck in the Risdon and the high cervical anteroparotid transmasseteric (HAT) approaches. METHODS: An anatomic study was performed on 18 formalin-embalmed cadavers. We performed a Risdon approach on the left side, and an HAT approach on the right side in all the cases. The subjects were placed in a normative frame and the force necessary to maintain a satisfactory exposure of the condyle was measured with a system of cables, pulleys, and mechanical dynamometer...
April 20, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28426685/human-african-trypanosomiasis-control-achievements-and-challenges
#3
Serap Aksoy, Phillipe Buscher, Mike Lehane, Philippe Solano, Jan Van Den Abbeele
Sleeping sickness, also known as human African trypanosomiasis (HAT), is a neglected disease that impacts 70 million people living in 1.55 million km2 in sub-Saharan Africa. Since the beginning of the 20th century, there have been multiple HAT epidemics in sub-Saharan Africa, with the most recent epidemic in the 1990s resulting in about half a million HAT cases reported between 1990 and 2015. Here we review the status of HAT disease at the current time and the toolbox available for its control. We also highlight future opportunities under development towards novel or improved interventions...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28426192/profiling-cellular-substrates-of-lysine-acetyltransferases-gcn5-and-p300-with-orthogonal-labeling-and-click-chemistry
#4
Zhen Han, Chau-Wen Chou, Xiangkun Yang, Michael G Bartlett, Y George Zheng
p300 and GCN5 are two representative histone/lysine acetyltransferase (HAT/KAT) enzymes in mammalian cells. It was recently reported that they possess multiple acyltransferase activities including acetylation, propionylation, and butyrylation of the -amino group of lysine residues of histones and non-histone protein substrates. Although thousands of acetylated substrates and acetylation sites have been identified by mass spectrometry-based proteomic screening, our knowledge about protein acylation, especially the causative connection between individual KAT members and their substrates remain limited...
April 20, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28424974/transposable-elements-in-the-anopheles-funestus-transcriptome
#5
Rita D Fernández-Medina, Claudia M A Carareto, Cláudio J Struchiner, José M C Ribeiro
Transposable elements (TEs) are present in most of the eukaryotic genomes and their impact on genome evolution is increasingly recognized. Although there is extensive information on the TEs present in several eukaryotic genomes, less is known about the expression of these elements at the transcriptome level. Here we present a detailed analysis regarding the expression of TEs in Anopheles funestus, the second most important vector of human malaria in Africa. Several transcriptionally active TE families belonging both to Class I and II were identified and characterized...
April 19, 2017: Genetica
https://www.readbyqxmd.com/read/28424723/evidence-mechanism-and-alternative-chemical-seedbank-level-control-of-glyphosate-resistance-of-a-rigid-ryegrass-lolium-rigidum-biotype-from-southern-spain
#6
Pablo T Fernández-Moreno, Fernando Bastida, Rafael De Prado
Rigid ryegrass (Lolium rigidum) is one of the most troublesome weeds in different crops in the Mediterranean region. A rigid ryegrass biotype from an olive grove in Jaén province (Andalusía, southern Spain), potentially resistant to glyphosate (RG), was tested for its resistance level through dose-response assays using a susceptible biotype (SG). To test the hypothesis of a non-target-site-based resistance, as point mutations are far less common mechanisms of glyphosate resistance, studies were also conducted to elucidate whether resistance was associated with biochemical, metabolism, molecular and/or physiological mechanisms...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28424240/the-histone-acetyltransferase-gcn5-positively-regulates-t-cell-activation
#7
Beixue Gao, Qingfei Kong, Yana Zhang, Chawon Yun, Sharon Y R Dent, Jianxun Song, Donna D Zhang, Yiming Wang, Xuemei Li, Deyu Fang
Histone acetyltransferases (HATs) regulate inducible transcription in multiple cellular processes and during inflammatory and immune response. However, the functions of general control nonrepressed-protein 5 (Gcn5), an evolutionarily conserved HAT from yeast to human, in immune regulation remain unappreciated. In this study, we conditionally deleted Gcn5 (encoded by the Kat2a gene) specifically in T lymphocytes by crossing floxed Gcn5 and Lck-Cre mice, and demonstrated that Gcn5 plays important roles in multiple stages of T cell functions including development, clonal expansion, and differentiation...
April 19, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28422392/hepatic-artery-reconstruction-in-living-donor-liver-transplantation-using-surgical-loupes-achieving-low-rate-of-hepatic-arterial-thrombosis-in-consecutive-741-recipients-tips-and-tricks-to-overcome-the-poor-hepatic-arterial-flow
#8
Ping-Chun Li, Ashok Thorat, Long-Bin Jeng, Horng-Ren Yang, Ming-Li Li, Chun-Chieh Yeh, Te-Hung Chen, Shih-Chao Hsu, Kin-Shing Poon
BACKGROUND: The reconstruction of hepatic artery (HA) is most complex step in living donor liver transplantation (LDLT) due to smaller diameter of the artery and increased risk of HA related complications. Due to smaller diameter of the HA, many centres use microsurgical technique with interrupted sutures for arterial anastomosis. Aim of our study was to retrospectively investigate the outcomes after HA reconstruction performed under magnifying loupes using "parachute technique". MATERIALS AND METHODS: From August 2002 to 31(st) August 2016, LDLT was performed in 766 recipients...
April 19, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28419509/automatic-diagnosis-of-vulvovaginal-candidiasis-from-pap-smear-images
#9
M Momenzadeh, M Sehhati, A Mehri Dehnavi, A Talebi, H Rabbani
Vulvovaginal candidiasis (VVC) is the most common genital infections that are seen every day in clinics. This infection is due to excessive growth of Candida that are normally present in the vagina in small numbers. Diagnosis of VVC is routinely done by direct microscopy of Pap smear samples and searching for the Candida in the Pap smear glass slides. This manual method is subjective, time consuming, labour-intensive and tedious. This study presents a computer-aided diagnostic (CAD) method to improve human diagnosis of VVC...
April 17, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28418886/histone-hypoacetylation-contributes-to-cxcl12-downregulation-in-colon-cancer-impact-on-tumor-growth-and-cell-migration
#10
Benoît Romain, Radhia Benbrika-Nehmar, Laetitia Marisa, Michèle Legrain, Viviane Lobstein, Attila Oravecz, Laetitia Poidevin, Cyril Bour, Jean-Noël Freund, Isabelle Duluc, Dominique Guenot, Erwan Pencreach
CXCL12 has been shown to be involved in colon cancer metastasis, but its expression level and molecular mechanisms regulating its expression remain controversial. We thus evaluated CXCL12 expression in a large cohort of colon adenomas and carcinomas, investigated for an epigenetic mechanism controlling its expression and evaluated the impact of CXCL12 levels on cell migration and tumor growth. CXCL12 expression was measured in human colon adenomas and carcinomas with transcriptome array and RT-qPCR. The promoter methylation was analyzed with whole-genome DNA methylation chips and protein expression by immunohistochemistry...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416100/synthesis-and-biological-evaluation-of-largazole-zinc-binding-group-analogs
#11
Bumki Kim, Ranjala Ratnayake, Hyunji Lee, Guqin Shi, Sabrina L Zeller, Chenglong Li, Hendrik Luesch, Jiyong Hong
Histone acetylation is an extensively investigated post-translational modification that plays an important role as an epigenetic regulator. It is controlled by histone acetyl transferases (HATs) and histone deacetylases (HDACs). The overexpression of HDACs and consequent hypoacetylation of histones have been observed in a variety of different diseases, leading to a recent focus of HDACs as attractive drug targets. The natural product largazole is one of the most potent natural HDAC inhibitors discovered so far and a number of largazole analogs have been prepared to define structural requirements for its HDAC inhibitory activity...
April 4, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28416070/-intentional-suicide-with-cyclizine
#12
Nikolaj Preus Hatting, Peter Martin Hansen
Cyclizine is an antihistamine with a sedative effect. In Denmark it is an over-the-counter drug, whereas it is a prescription drug in many other countries. It possesses anticholinergic and antiemetic properties, although the exact mechanism of action is unknown. At doses greater than 5 mg/kg potent side effects of anticholinergic character can be expected. This case report is a description of an intentional suicide with a dose greater than 70 mg/kg.
April 3, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28405966/pointwise-influence-matrices-for-functional-response-regression
#13
Philip T Reiss, Lei Huang, Pei-Shien Wu, Huaihou Chen, Stan Colcombe
We extend the notion of an influence or hat matrix to regression with functional responses and scalar predictors. For responses depending linearly on a set of predictors, our definition is shown to reduce to the conventional influence matrix for linear models. The pointwise degrees of freedom, the trace of the pointwise influence matrix, are shown to have an adaptivity property that motivates a two-step bivariate smoother for modeling nonlinear dependence on a single predictor. This procedure adapts to varying complexity of the nonlinear model at different locations along the function, and thereby achieves better performance than competing tensor product smoothers in an analysis of the development of white matter microstructure in the brain...
April 12, 2017: Biometrics
https://www.readbyqxmd.com/read/28399060/thoracoscopic-esophagectomy-in-the-prone-position-versus-the-lateral-position-hand-assisted-thoracoscopic-surgery-a-retrospective-cohort-study-of-127-consecutive-esophageal-cancer-patients
#14
Naoya Fukuda, Toshiaki Shichinohe, Yuma Ebihara, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Yo Kurashima, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Satoshi Hirano
PURPOSE: To assess the validity of esophagectomy with the patient in the prone position (PP), the short-term surgical results of PP and hand-assisted thoracoscopic surgery (HATS) were compared. METHODS: This study enrolled 127 patients who underwent esophagectomy with HATS (n=91) or PP (n=36) between October 1999 and September 2014. The patients' background characteristics, operative findings, and postoperative complications were examined. RESULTS: The patients' background characteristics were not significantly different...
April 10, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28397756/anti-trypanosomatid-elemanolide-sesquiterpene-lactones-from-vernonia-lasiopus-o-hoffm
#15
Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt
Sleeping sickness or human African trypanosomiasis (HAT) is a neglected tropical disease (NTD) threatening millions of peoples' lives with thousands infected. The disease is endemic in poorly developed regions of sub-Saharan Africa and is caused by the kinetoplastid "protozoan" parasite Trypanosoma brucei. The parasites are transmitted to humans through bites of infected tsetse flies of the genus Glossina. The few available drugs for treatment of this disease are highly toxic, difficult to administer, costly and unavailable to poor rural communities bearing the major burden of this infection...
April 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28396698/internal-modifications-in-the-cenp-a-nucleosome-modulate-centromeric-dynamics
#16
Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A Papoian, Yamini Dalal
BACKGROUND: Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have been reported, and their functions remain largely unexplored. In this multidisciplinary report, we utilize in silico computational and in vivo approaches to dissect lysine 124 of human CENP-A, which was previously reported to be acetylated in advance of replication...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28393017/photoacoustic-signal-characterization-of-cancer-treatment-response-correlation-with-changes-in-tumor-oxygenation
#17
Eno Hysi, Lauren A Wirtzfeld, Jonathan P May, Elijus Undzys, Shyh-Dar Li, Michael C Kolios
Frequency analysis of the photoacoustic radiofrequency signals and oxygen saturation estimates were used to monitor the in-vivo response of a novel, thermosensitive liposome treatment. The liposome encapsulated doxorubicin (HaT-DOX) releasing it rapidly (<20 s) when the tumor was exposed to mild hyperthermia (43 °C). Photoacoustic imaging (VevoLAZR, 750/850 nm, 40 MHz) of EMT-6 breast cancer tumors was performed 30 min pre- and post-treatment and up to 7 days post-treatment (at 2/5/24 h timepoints)...
March 2017: Photoacoustics
https://www.readbyqxmd.com/read/28386802/description-of-hyphopichia-buzzinii-f-a-sp-nov-and-hyphopichia-homilentoma-comb-nov-the-teleomorph-of-candida-homilentoma
#18
Lucas R Ribeiro, Ana R O Santos, Marizeth Groenewald, Maudy Th H Smith, Carla A Lara, Aristóteles Góes-Neto, Noémie Jacques, Cécile Grondin, Serge Casaregola, Marc-André Lachance, Carlos A Rosa
During studies of the yeast diversity associated with rotting wood in Brazil and fruits, plants and insects in French Guiana, three strains of a new species were isolated. Analysis of the sequences of the internal transcribed spacer (ITS)-5.8S and D1/D2 domains of the large subunit of the rRNA gene showed that this species belongs to the genus Hyphopichia and its closest relative is Candida homilentoma. These species differ by 44 nucleotide substitutions in D1/D2 sequences. A new species Hyphopichia buzzinii f...
April 6, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28384743/annals-story-slam-harry-and-the-dreaded-hat
#19
Mark Angelo
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28378490/augenbeteiligung-beim-pemphigus-vulgaris-retrospektive-studie-an-einer-gro%C3%A3-en-spanischen-kohorte
#20
Agustin España, Pilar Iranzo, Josep Herrero-González, José M Mascaro, Ricardo Suárez
HINTERGRUND UND ZIELE: Es gibt nur wenige Berichte zur Beteiligung der okulären/periokulären Region beim Pemphigus vulgaris (PV). Ziel der vorliegenden Studie war es, das Krankheitsbild des okulären PV (OPV) zu untersuchen und seinen prognostischen Wert zu definieren. PATIENTEN UND METHODIK: Zwischen 1985 und 2014 wurden insgesamt 167 Patienten mit Pemphigus vulgaris an vier tertiären spanischen Krankenhäusern behandelt. Wir haben alle Patienten mit OPV in diese retrospektive Studie aufgenommen...
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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