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https://www.readbyqxmd.com/read/28736011/pediatric-donor-to-adult-recipients-in-donation-after-cardiac-death-liver-transplantation-a-single-center-experience
#1
C Lan, J L Song, L N Yan, J Y Yang, T F Wen, B Li, M Q Xu
BACKGROUND: The impact of using liver allografts from donors who are younger than 14 years at the time of donation after cardiac death (DCD) liver transplantation in terms of early allograft dysfunction (EAD) and graft survival is undefined. To determine if adults undergoing DCD liver transplantation who receive a graft from a donor age younger than or equal to 13 years have similar outcomes to recipients of organs from older than 18-year-old donors. METHODS: Records from adult patients undergoing DCD liver transplantation between March 2012 and December 2015 who received whole grafts from donors after cardiac death were reviewed...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28731338/tunable-magnetism-and-extraordinary-sunlight-absorbance-in-indium-triphosphide-monolayer
#2
Naihua Miao, Bin Xu, Nicholas C Bristowe, Jian Zhou, Zhimei Sun
Atomically thin two-dimensional (2D) materials have received considerable research interest due to their extraordinary properties and promising applications. Here we predict the mono-layered indium triphosphide (InP3) as a new semiconducting 2D material with a range of favourable functional properties by means of ab initio calculations. The 2D InP3 crystal shows high stability and promise of experimental synthesis. It possesses an indirect band-gap of 1.14 eV and a high electron mobility of 1919 cm(2)V(-1)s(-1), which can be strongly manipulated with applied strain...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28723153/understanding-the-reactivity-of-co3-%C3%A2-and-no2-%C3%A2-radicals-towards-s-containing-and-aromatic-amino-acids
#3
Sharmistha Karmakar, Ayan Datta
The reactivity of CO3-(.) and NO2(.) radicals towards six amino acid side chains namely, cysteine (Cys), methionine (Met), phenylalanine (Phe), tyrosine (Tyr), histidine (His) and tryptophan (Trp), has been explored using state-of-art density functional theory (DFT) and transition state theory (TST). Three reaction mechanisms, namely hydrogen atom abstraction (HAT), radical adduct formation (RAF) and single electron transfer (SET) have been considered for detailed study. While CO3-(.) radical is highly reactive towards majority of amino acids, the reactivity of NO2(...
July 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28708162/high-energy-nd-yag-laser-system-with-arbitrary-sub-nanosecond-pulse-shaping-capability
#4
R A Meijer, A S Stodolna, K S E Eikema, S Witte
We report on a laser system capable of generating high-energy (>270  mJ) temporally shaped pulses at 1064 nm with 0.43-ns shaping resolution. The pulses are generated by modulation of a continuous-wave seed laser and subsequent amplification by a dual-stage grazing-incidence Nd:YVO4 "bounce" amplifier and a Nd:YAG power amplifier (all quasi-continuous diode-pumped). The system produces pulses with a high-quality top-hat spatial beam profile with up to 0.6 GW of peak power and 44 W of average power, a power stability of 0...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28701721/tsg-6-secreted-by-human-adipose-tissue-derived-mesenchymal-stem-cells-ameliorates-dss-induced-colitis-by-inducing-m2-macrophage-polarization-in-mice
#5
Woo-Jin Song, Qiang Li, Min-Ok Ryu, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung, Hwa-Young Youn
Previous studies have revealed that mesenchymal stem cells (MSCs) alleviate inflammatory bowel disease (IBD) by modulating inflammatory cytokines in the inflamed intestine. However, the mechanisms underlying these effects are not completely understood. We sought to investigate the therapeutic effects of human adipose tissue-derived (hAT)-MSCs in an IBD mouse model and to explore the mechanisms of the regulation of inflammation. Dextran sulfate sodium-induced colitis mice were infused with hAT-MSCs intraperitoneally and colon tissues were collected on day 10...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700106/crystallization-of-a-two-dimensional-hydrogen-bonded-molecular-assembly-evolution-of-the-local-structure-resolved-by-atomic-force-microscopy
#6
Laerte L Patera, Xunshan Liu, Nico Mosso, Silvio Decurtins, Shi-Xia Liu, Jascha Repp
Surface-assisted self-assembly structures of the aromatic N-heterocyclic hexaazatriphenylene (HAT) molecular synthon were determined with sub-Å resolution by means of noncontact Atomic Force Microscopy (nc-AFM), both in the kinetically trapped amorphous state and in the thermodynamically stable crystalline phase. These results reveal how, for non-flexible molecular species, the crystallization governs the length-scale of the network order, without affecting the local bonding schemes. The capability of nc-AFM to accurately resolve structural relaxations will be highly relevant for the characterization of vitreous structure of 2-dimensional supramolecular materials...
July 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28699626/in-vitro-and-in-vivo-investigation-of-high-intensity-focused-ultrasound-hifu-hat-type-ablation-mode
#7
Hongya Dai, Fei Chen, Sijing Yan, Xiaoya Ding, Dazhao Ma, Jing Wen, Die Xu, Jianzhong Zou
BACKGROUND The aim of this study was to investigate the feasibility of the application of high-intensity focused ultrasound (HIFU) hat-type ablation mode in in vitro and in vivo models, and to compare the ablation effects of different parameter combinations. MATERIAL AND METHODS HIFU hat-type ablation was performed in isolated bovine liver tissue and in the liver tissue in living rabbits, and the coagulative necrosis for different parameter combinations (plane angles and irradiation order) was investigated...
July 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28698054/bistacrines-as-potential-antitrypanosomal-agents
#8
Ines Schmidt, Sarah Göllner, Antje Fuß, August Stich, Anna Kucharski, Tanja Schirmeister, Elena Katzowitsch, Heike Bruhn, Alexandra Miliu, R Luise Krauth-Siegel, Ulrike Holzgrabe
Human African Trypanosomiasis (HAT) is caused by two subspecies of the genus Trypanosoma, namely Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. The disease is fatal if left untreated and therapy is limited due to only five non-adequate drugs currently available. In preliminary studies, dimeric tacrine derivatives were found to inhibit parasite growth with IC50-values in the nanomolar concentration range. This prompted the synthesis of a small, but smart library of monomeric and dimeric tacrine-type compounds and their evaluation of antiprotozoal activity...
July 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28697937/complications-after-endovascular-treatment-of-hepatic-artery-stenosis-after-liver-transplantation
#9
Leighton E Goldsmith, Kristy Wiebke, John Seal, Clayton Brinster, Taylor A Smith, Hernan A Bazan, W Charles Sternbergh
BACKGROUND: Hepatic artery stenosis (HAS) after liver transplantation can progress to hepatic artery thrombosis (HAT) and a subsequent 30% to 50% risk of graft loss. Although endovascular treatment of severe HAS after liver transplantation has emerged as the dominant method of treatment, the potential risks of these interventions are poorly described. METHODS: A retrospective review of all endovascular interventions for HAS after liver transplantation between August 2009 and March 2016 was performed at a single institution, which has the largest volume of liver transplants in the United States...
July 8, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28695440/an-ir-sensor-based-smart-system-to-approximate-core-body-temperature
#10
Partha Pratim Ray
Herein demonstrated experiment studies two methods, namely convection and body resistance, to approximate human core body temperature. The proposed system is highly energy efficient that consumes only 165 mW power and runs on 5 VDC source. The implemented solution employs an IR thermographic sensor of industry grade along with AT Mega 328 breakout board. Ordinarily, the IR sensor is placed 1.5-30 cm away from human forehead (i.e., non-invasive) and measured the raw data in terms of skin and ambient temperature which is then converted using appropriate approximation formula to find out core body temperature...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28689336/v79-fibroblasts-are-protected-against-reactive-oxygen-species-by-flax-fabric
#11
Katarzyna Skórkowska-Telichowska, Anna Kulma, Tomasz Gębarowski, Wioleta Wojtasik, Kamil Kostyn, Helena Moreira, Anna Szyjka, Aleksandra Boba, Marta Preisner, Justyna Mierziak, Malgorzata Arendt, Anna Kostyn, Michał Szatkowski, Jan Szopa, Kazimierz Gąsiorowski
Chinese hamster pulmonary fibroblasts (V79 cells) pre-treated with flax fabrics derived from non-modified or genetically engineered flax fibres and treated with H2O2 revealed a markedly lower level of intracellular reactive oxygen species (ROS) than control, non-pre-treated cells. The fabrics were prepared from fibres derived from two kinds of transgenic plants: W92 plants, which overproduce flavonoids, and M type plants, which produce hydroxybutyrate polymer in their vascular bundles and thus in fibres. Incubating the V79 cells with the flax fabrics prior to H2O2 treatment also reduced the amount of DNA damage, as established using the comet assay (also known as alkaline single-cell gel electrophoresis) and pulsed-field electrophoresis of intact cellular DNA...
July 8, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28686912/antiproliferative-and-apoptotic-activities-of-sequence-specific-histone-acetyltransferase-inhibitors
#12
Zutao Yu, Junichi Taniguchi, Yulei Wei, Ganesh N Pandian, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama
In parallel to monomeric epigenetic regulators, sequence-specific epigenetic regulators represent versatile synthetic dual-target ligands that achieve regulatory control over multi-gene networks. Development of DNA-binding domain (DBD)-HDAC inhibitors and DBD-HAT activators, which result in increased histone acetylation, has become one promising research field. However, there is no report regarding the gene regulatory pattern by sequence-specific epigenetic repressor. We report here for the first time, the synthesis of DBD-HAT inhibitors and demonstrate that these conjugates could retain their dual-target activity using predicted working model of thermal stability assay and in vitro HAT activity assay...
June 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28685111/ultrasmall-magnetic-field-effect-and-sign-reversal-in-transistors-based-on-donor-acceptor-systems
#13
Thomas Reichert, Tobat P I Saragi
We present magnetoresistive organic field-effect transistors featuring ultrasmall magnetic field-effects as well as a sign reversal. The employed material systems are coevaporated thin films with different compositions consisting of the electron donor 2,2',7,7'-tetrakis-(N,N-di-p-methylphenylamino)-9,9'-spirobifluorene (Spiro-TTB) and the electron acceptor 1,4,5,8,9,12-hexaazatriphenylene hexacarbonitrile (HAT-CN). Intermolecular charge transfer between Spiro-TTB and HAT-CN results in a high intrinsic charge carrier density in the coevaporated films...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28684718/steroid-alkaloids-from-holarrhena-africana-with-strong-activity-against-trypanosoma-brucei-rhodesiense
#14
Charles Okeke Nnadi, Ngozi Justina Nwodo, Marcel Kaiser, Reto Brun, Thomas J Schmidt
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, "sleeping sickness"), we have investigated extracts from the leaves and bark of the West African Holarrhenaafricana (syn. Holarrhena floribunda; Apocynaceae). The extracts and their alkaloid-enriched fractions displayed promising in vitro activity against bloodstream forms of T. brucei rhodesiense (Tbr; East African HAT). Bioactivity-guided chromatographic fractionation of the alkaloid-rich fractions resulted in the isolation of 17 steroid alkaloids, one nitrogen-free steroid and one alkaloid-like non-steroid...
July 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28684709/trypanosoma-brucei-inhibition-by-essential-oils-from-medicinal-and-aromatic-plants-traditionally-used-in-cameroon-azadirachta-indica-aframomum-melegueta-aframomum-daniellii-clausena-anisata-dichrostachys-cinerea-and-echinops-giganteus
#15
Stephane L Ngahang Kamte, Farahnaz Ranjbarian, Gustavo Daniel Campagnaro, Prosper C Biapa Nya, Hélène Mbuntcha, Verlaine Woguem, Hilaire Macaire Womeni, Léon Azefack Ta, Cristiano Giordani, Luciano Barboni, Giovanni Benelli, Loredana Cappellacci, Anders Hofer, Riccardo Petrelli, Filippo Maggi
Essential oils are complex mixtures of volatile components produced by the plant secondary metabolism and consist mainly of monoterpenes and sesquiterpenes and, to a minor extent, of aromatic and aliphatic compounds. They are exploited in several fields such as perfumery, food, pharmaceutics, and cosmetics. Essential oils have long-standing uses in the treatment of infectious diseases and parasitosis in humans and animals. In this regard, their therapeutic potential against human African trypanosomiasis (HAT) has not been fully explored...
July 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28680870/comparison-of-the-effect-of-plastic-cover-and-blanket-on-body-temperature-of-preterm-infants-hospitalized-in-nicu-randomized-clinical-trial
#16
Leila Valizadeh, Majid Mahallei, Abdolrasoul Safaiyan, Fatemeh Ghorbani, Maryam Peyghami
Introduction: Preterm infants are unable to regulate their body temperature and there are insufficient research evidences on different kinds of covers for hospitalized preterm infants; therefore, the present study was conducted with the aim of comparing the effects of plastic and blanket covers on the body temperature of preterm infants under radiant warmer. Methods: This randomized cross-over clinical trial was carried out upon 80 infants with the gestational age of 28-30 weeks and birth weight of 800- 1250 gr who were in Neonatal Intensive Care Unit on the second day of their hospitalization...
June 2017: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28679527/ornithine-uptake-and-the-modulation-of-drug-sensitivity-in-trypanosoma-brucei
#17
Juan P Macedo, Rachel B Currier, Corina Wirdnam, David Horn, Sam Alsford, Doris Rentsch
Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO "essential medicine" eflornithine, which is antagonistic to another anti-HAT drug, suramin. Thus, ornithine uptake has important consequences in T. brucei, but the transporters have not been identified. We describe these amino acid transporters (AATs). In a heterologous expression system, TbAAT10-1 is selective for ornithine, whereas TbAAT2-4 transports both ornithine and histidine...
July 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28678170/differential-effects-of-histone-acetyltransferase-gcn5-or-pcaf-knockdown-on-urothelial-carcinoma-cells
#18
Evangelia A Koutsogiannouli, Nicholas Wagner, Christiane Hader, Maria Pinkerneil, Michèle J Hoffmann, Wolfgang A Schulz
Disturbances in histone acetyltransferases (HATs) are common in cancers. In urothelial carcinoma (UC), p300 and CBP are often mutated, whereas the GNAT family HATs GCN5 and PCAF (General Control Nonderepressible 5, p300/CBP-Associated Factor) are often upregulated. Here, we explored the effects of specific siRNA-mediated knockdown of GCN5, PCAF or both in four UC cell lines (UCCs). Expression of various HATs and marker proteins was measured by qRT-PCR and western blot. Cellular effects of knockdowns were analyzed by flow cytometry and ATP-, caspase-, and colony forming-assays...
July 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28674280/interplay-between-chromatin-modulators-and-histone-acetylation-regulates-the-formation-of-accessible-chromatin-in-the-upstream-regulatory-region-of-fission-yeast-fbp1
#19
Akira Adachi, Satoshi Senmatsu, Ryuta Asada, Takuya Abe, Charles S Hoffman, Kunihiro Ohta, Kouji Hirota
Numerous noncoding RNA transcripts are detected in eukaryotic cells. Noncoding RNAs transcribed across gene promoters are involved in the regulation of mRNA transcription via chromatin modulation. This function of noncoding RNA transcription was first demonstrated for the fission yeast fbp1 gene, where a cascade of noncoding RNA transcription events induces chromatin remodeling to facilitate transcription factor binding. We recently demonstrated that the noncoding RNAs from the fbp1 upstream region facilitate binding of the transcription activator Atf1 and thereby promote histone acetylation...
June 30, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28672036/performance-of-the-sd-bioline%C3%A2-hat-rapid-test-in-various-diagnostic-algorithms-for-gambiense-human-african-trypanosomiasis-in-the-democratic-republic-of-the-congo
#20
Crispin Lumbala, Paul R Bessell, Pascal Lutumba, Sylvain Baloji, Sylvain Biéler, Joseph M Ndung'u
We carried out a study to compare the performance, in terms of sensitivity and specificity, of the new SD BIOLINE® HAT rapid diagnostic test (RDT) with the card agglutination test for trypanosomiasis (CATT) for diagnosis of human African trypanosomiasis (HAT) in the Democratic Republic of the Congo (DRC). Participants were enrolled actively by four mobile teams, and passively at four health facilities in three provinces. Consenting participants were tested concurrently with the RDT and CATT on whole blood...
2017: PloS One
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