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https://www.readbyqxmd.com/read/28335486/implicit-regularization-for-reconstructing-3d-building-rooftop-models-using-airborne-lidar-data
#1
Jaewook Jung, Yoonseok Jwa, Gunho Sohn
With rapid urbanization, highly accurate and semantically rich virtualization of building assets in 3D become more critical for supporting various applications, including urban planning, emergency response and location-based services. Many research efforts have been conducted to automatically reconstruct building models at city-scale from remotely sensed data. However, developing a fully-automated photogrammetric computer vision system enabling the massive generation of highly accurate building models still remains a challenging task...
March 19, 2017: Sensors
https://www.readbyqxmd.com/read/28334966/structural-and-mechanistic-insights-into-regulation-of-hbo1-histone-acetyltransferase-activity-by-brpf2
#2
Ye Tao, Chen Zhong, Junjun Zhu, Shutong Xu, Jianping Ding
HBO1, a member of the MYST family of histone acetyltransferases (HATs), is required for global acetylation of histone H3K14 and embryonic development. It functions as a catalytic subunit in multisubunit complexes comprising a BRPF1/2/3 or JADE1/2/3 scaffold protein, and two accessory proteins. BRPF2 has been shown to be important for the HAT activity of HBO1 toward H3K14. Here we demonstrated that BRPF2 can regulate the HAT activity of HBO1 toward free H3 and H4, and nucleosomal H3. Particularly, a short N-terminal region of BRPF2 is sufficient for binding to HBO1 and can potentiate its activity toward H3K14...
February 24, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28332743/nitrene-radical-approach-to-saturated-heterocycles-cobalt-porphyrin-catalysed-intramolecular-ring-closing-c-h-amination-of-aliphatic-azides
#3
Bas de Bruin, Petrus F Kuijpers, Martijn J Tiekink, Willem B Breukelaar, Daniël L J Broere, Nicolaas P van Leest, Jarl Ivar van der Vlugt, Joost N H Reek
Cobalt porphyrin catalysed intramolecular ring-closing C-H bond amination enables direct synthesis of various N-heterocycles from aliphatic azides. Pyrrolidines, oxazolidines imidazolidines, isoindolines and tetrahydroisoquinoline can be obtained in good to excellent yields in a single reaction step with an air and moisture stable catalyst. Kinetic studies of the reaction in combination with DFT calculations reveal a metallo-radical-type mechanism involving rate limiting azide activation to form the key cobalt(III)-nitrene radical intermediate...
March 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28332273/reducing-the-incidence-of-hepatic-artery-thrombosis-in-pediatric-liver-transplantation-effect-of-microvascular-techniques-and-a-customized-anticoagulation-protocol
#4
William A Ziaziaris, Alexandre Darani, Andrew J A Holland, Angus Alexander, Jonathan Karpelowsky, Pasquale Barbaro, Michael Stormon, Edward O'Loughlin, Albert Shun, Gordon Thomas
We aimed to assess the incidence of HAT over three eras following implementation of microvascular techniques and a customized anticoagulation protocol in a predominantly cadaveric split liver transplant program. We retrospectively reviewed pediatric liver transplants performed between April 1986 and 2016 and analyzed the incidence HAT over three eras. In E1, 1986-2008, each patient received a standard dose of 5 U/kg/h of heparin and coagulation profiles normalized passively. In E2, 2008-2012, microvascular techniques were introduced...
March 22, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28329788/defining-health-trajectories-in-older-adults-with-five-clinical-indicators
#5
Giola Santoni, Alessandra Marengoni, Amaia Calderón-Larrañaga, Sara Angleman, Debora Rizzuto, Anna-Karin Welmer, Francesca Mangialasche, Nicola Orsini, Laura Fratiglioni
Background: People age differently, challenging the identification of those more at risk of rapid health deterioration. This study aimed to explore the heterogeneity in the health of older adults by using five clinical indicators to detect age-related variation and individual health trajectories over time. Methods: Health of 3,363 people aged 60+ from the Swedish National study on Aging and Care-Kungsholmen (SNAC-K) assessed at baseline and at 3- and 6-year follow-ups...
October 19, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28326109/effects-of-education-on-differential-item-functioning-on-the-15-item-modified-korean-version-of-the-boston-naming-test
#6
Byung-Soo Kim, Dong-Woo Lee, Jae-Nam Bae, Ji-Hyun Kim, Shinkyum Kim, Ki Woong Kim, Jee-Eun Park, Maeng Je Cho, Sung Man Chang
OBJECTIVE: Education is expected to have an effect on differential item functioning (DIF) on the 15-item Modified Boston Naming Test in the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (BNT-KC). However, no study has examined DIF in the BNT-KC. METHODS: We used the item response theory to investigate the impact of education on the DIF in the BNT-KC among elderly individuals with or without dementia (n=720). A two-parameter item response model was used to determine the difficulty and discrimination parameters of each item...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28325314/the-use-of-calcium-ions-instead-of-heat-treatment-for-%C3%AE-1-3-glucan-gelation-improves-biocompatibility-of-the-%C3%AE-1-3-glucan-ha-bone-scaffold
#7
Katarzyna Klimek, Agata Przekora, Aleksandra Benko, Wiktor Niemiec, Marta Blazewicz, Grazyna Ginalska
The aim of this study was to determine which procedure for β-1,3-glucan gelation - newly developed dialysis against calcium salt or described in the literature thermal technique - is more appropriate for fabrication of a biomaterial designed for bone tissue engineering applications. Thus, β-1,3-glucan/hydroxyapatite scaffolds were prepared based on two different methods and their physicochemical, microstructural, and biological properties were compared. Obtained results demonstrated that unlike thermal method-prepared β-1,3-glucan/hydroxyapatite material (glu/HAT), bone scaffold fabricated via dialysis method (glu/HA D) possessed rough surface resulting from the presence of CaCl2 precipitates as proven by SEM and EDS analysis...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28324141/early-hepatic-artery-thrombosis-after-liver-transplantation-what-is-the-impact-of-the-arterial-reconstruction-type
#8
Astrid Herrero, Regis Souche, Emmanuel Joly, Gildas Boisset, Hussein Habibeh, Hassan Bouyabrine, Fabrizio Panaro, Jose Ursic-Bedoya, Samir Jaber, Boris Guiu, Georges Philippe Pageaux, Francis Navarro
OBJECTIVE: Hepatic artery thrombosis (HAT) is the most severe vascular complication occurring after liver transplantation, with an incidence ranging from 2 to 9% in adults. Although the ideal arterial reconstruction is often described as a short and non-redundant anastomosis fashioned between the recipient and donor hepatic arteries, there is no strong evidence about this ideal reconstruction in the literature. The aim of this study was to assess the impact of the type of arterial reconstruction on early HAT after primary liver transplantation...
March 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28321260/loop-mediated-isothermal-amplification-test-for-trypanosoma-gambiense-group-1-with-stem-primers-a-molecular-xenomonitoring-test-for-sleeping-sickness
#9
Zablon K Njiru, Cecilia K Mbae, Gitonga N Mburugu
The World Health Organization has targeted Human African Trypanosomiasis (HAT) for elimination by 2020 with zero incidence by 2030. To achieve and sustain this goal, accurate and easy-to-deploy diagnostic tests for Gambian trypanosomiasis which accounts for over 98% of reported cases will play a crucial role. Most needed will be tools for surveillance of pathogen in vectors (xenomonitoring) since population screening tests are readily available. The development of new tests is expensive and takes a long time while incremental improvement of existing technologies that have potential for xenomonitoring may offer a shorter pathway to tools for HAT surveillance...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28321249/mexican-hat-wavelet-kernel-elm-for-multiclass-classification
#10
Jie Wang, Yi-Fan Song, Tian-Lei Ma
Kernel extreme learning machine (KELM) is a novel feedforward neural network, which is widely used in classification problems. To some extent, it solves the existing problems of the invalid nodes and the large computational complexity in ELM. However, the traditional KELM classifier usually has a low test accuracy when it faces multiclass classification problems. In order to solve the above problem, a new classifier, Mexican Hat wavelet KELM classifier, is proposed in this paper. The proposed classifier successfully improves the training accuracy and reduces the training time in the multiclass classification problems...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28319625/photoprotection-prevents-skin-cancer-let-s-make-it-fashionable-to-wear-sun-protective-clothing
#11
Jeffrey M Milch, Nicholas F Logemann
Protection from UV radiation (UVR) is of paramount importance in preventing skin cancers, the majority of which occur on sun-exposed areas of the face, ears, and neck. A reusable, inexpensive, and truly simple measure of personal protection that greatly reduces exposure to UVR, thereby reducing the risk for developing skin cancers, can be achieved simply by regularly wearing a wide-brimmed hat. In some areas of the world where sunny climates are pervasive and exposure to UVR is part of everyday life, fashion trends, policy, and public health initiatives are in sync, and photoprotection with wide-brimmed hats is embraced as a common and fashionable practice...
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28318979/a-phytophthora-effector-manipulates-host-histone-acetylation-and-reprograms-defense-gene-expression-to-promote-infection
#12
Liang Kong, Xufang Qiu, Jiangang Kang, Yang Wang, Han Chen, Jie Huang, Min Qiu, Yao Zhao, Guanghui Kong, Zhenchuan Ma, Yan Wang, Wenwu Ye, Suomeng Dong, Wenbo Ma, Yuanchao Wang
Immune response during pathogen infection requires extensive transcription reprogramming. A fundamental mechanism of transcriptional regulation is histone acetylation. However, how pathogens interfere with this process to promote disease remains largely unknown. Here we demonstrate that the cytoplasmic effector PsAvh23 produced by the soybean pathogen Phytophthora sojae acts as a modulator of histone acetyltransferase (HAT) in plants. PsAvh23 binds to the ADA2 subunit of the HAT complex SAGA and disrupts its assembly by interfering with the association of ADA2 with the catalytic subunit GCN5...
March 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28314678/practices-of-infectious-control-management-during-neutropenia-a-survey-from-149-french-hospitals
#13
N Lequilliec, R Raymond, D Vanjak, N Baghdadi, H Boulestreau, J-R Zahar, J-P Gangneux
OBJECTIVE OF THE STUDY: Neutropenic patients represent a growing and fragile population in our hospitals. Numerous treatments induce neutropenia in haematology wards and elsewhere. Although strict isolation is recommended during post-haematopoietic stem cell transplantation neutropenia, this may not be the current practice in other situations. In this study, our objective was to analyse what protective measures are applied in neutropenic patients in a French survey. MATERIELS AND METHODS: A questionnaire was sent out to infection control teams of 400 public and private French hospitals to enquire about their local recommendations regarding infection prevention in neutropenic patients...
March 14, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28306721/developing-photoreceptor-based-models-of-visual-attraction-in-riverine-tsetse-for-use-in-the-engineering-of-more-attractive-polyester-fabrics-for-control-devices
#14
Roger D Santer
Riverine tsetse transmit the parasites that cause the most prevalent form of human African trypanosomiasis, Gambian HAT. In response to the imperative for cheap and efficient tsetse control, insecticide-treated 'tiny targets' have been developed through refinement of tsetse attractants based on blue fabric panels. However, modern blue polyesters used for this purpose attract many less tsetse than traditional phthalogen blue cottons. Therefore, colour engineering polyesters for improved attractiveness has great potential for tiny target development...
March 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28301168/deletion-of-a-histone-acetyltransferase-leads-to-the-pleiotropic-activation-of-natural-products-in-metarhizium-robertsii
#15
Aili Fan, Wubin Mi, Zhiguo Liu, Guohong Zeng, Peng Zhang, Youcai Hu, Weiguo Fang, Wen-Bing Yin
Histone deacetylation normally decreases the gene expression in organisms. By genome-wide deletions of epigenetic regulators in entomopathogenic fungus Metarhizium robertsii, unexpected activations of orphan secondary metabolite genes have been found upon the disruption of a histone acetyltransferase (HAT) gene Hat1. This led to the characterization of 11 new natural products, including eight isocoumarin derivatives meromusides A-H and two nonribosomal peptides meromutides A and B. Therefore, disruption of HAT represents a new approach to mine chemical diversity from fungi...
March 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28300476/ovarian-steroid-hormones-modulate-the-expression-of-progesterone-receptors-and-histone-acetylation-patterns-in-uterine-leiomyoma-cells
#16
Gabriela Dos Santos Sant'Anna, Ilma Simoni Brum, Gisele Branchini, Lolita Schneider Pizzolato, Edison Capp, Helena von Eye Corleta
Uterine leiomyomas are the most common benign smooth muscle cell tumors in women. Estrogen (E2), progesterone (P4) and environmental factors play important roles in the development of these tumors. New treatments, such as mifepristone, have been proposed. We evaluated the gene expression of total (PRT) and B (PRB) progesterone receptors, and the histone acetyltransferase (HAT) and deacetylase (HDAC) activity after treatment with E2, P4 and mifepristone (RU486) in primary cell cultures from uterine leiomyoma and normal myometrium...
March 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28300448/photoprotection-knowledge-and-behaviours-among-organ-transplant-recipients
#17
Kirsten Walker, Kerry Gardner, Angela Law, Nicole Hawkins, Peter Hull
BACKGROUND: Organ transplant recipients (OTRs) are at an increased risk of developing a de novo malignant neoplasm compared to the general population. The primary contributor to skin cancer in all patients is sun exposure. OBJECTIVE: In this study, we aim to ascertain both OTR skin cancer awareness and photoprotection practices. METHODS: A questionnaire-based study of Saskatchewan transplant recipients. RESULTS: Nearly all respondents were aware that sun exposure is the best-known cause of skin cancer and that as an OTR, they are at increased risk of skin cancer (99...
February 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28296592/ethanol-extract-of-capsella-bursa-pastoris-improves-hepatic-steatosis-through-inhibition-of-histone-acetyltransferase-activity
#18
Hyo-Kyoung Choi, Eun Ju Shin, Su Jin Park, Haeng Jeon Hur, Jae Ho Park, Min-Yu Chung, Myung Sunny Kim, Jin-Taek Hwang
Histone lysine acetylation is thought to play a role in regulating the balance between energy storage and energy expenditure. However, the epigenetic mechanisms by which food phytochemicals influence metabolic processes in the liver have not been thoroughly investigated. In this study, we investigated the effect of an ethanol extract of Capsella bursa-pastoris (ECB) on histone acetyltransferase (HAT) inhibition, and whether it could thereby attenuate lipid accumulation in vitro and in vivo. We observed that ECB inhibits HAT activity as assessed by colorimetric and autoradiography assay systems...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28286521/pulling-a-ligase-out-of-a-hat-pcaf-mediates-ubiquitination-of-the-class-ii-transactivator
#19
Julie E Morgan, Susanna F Greer
The Class II Transactivator (CIITA) is essential to the regulation of Major Histocompatibility Class II (MHC II) genes transcription. As the "master regulator" of MHC II transcription, CIITA regulation is imperative and requires various posttranslational modifications (PTMs) in order to facilitate its role. Previously we identified various ubiquitination events on CIITA. Monoubiquitination is important for CIITA transactivity, while K63 linked ubiquitination is involved in crosstalk with ERK1/2 phosphorylation, where together they mediate cellular movement from the cytoplasm to nuclear region...
2017: International Journal of Cell Biology
https://www.readbyqxmd.com/read/28280922/reaction-diffusion-and-non-local-interaction
#20
Hirokazu Ninomiya, Yoshitaro Tanaka, Hiroko Yamamoto
Recent years have seen the introduction of non-local interactions in various fields. A typical example of a non-local interaction is where the convolution kernel incorporates short-range activation and long-range inhibition. This paper presents the relationship between non-local interactions and reaction-diffusion systems in the following sense: (a) the relationship between the instability induced by non-local interaction and diffusion-driven instability; (b) the realization of non-local interactions by reaction-diffusion systems...
March 9, 2017: Journal of Mathematical Biology
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