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exercise and lipids

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https://www.readbyqxmd.com/read/28646016/tshb-mrna-is-linked-to-cholesterol-metabolism-in-adipose-tissue
#1
José María Moreno-Navarrete, María Moreno, Francisco Ortega, Gemma Xifra, Shangyu Hong, John M Asara, José C E Serrano, Mariona Jové, Pavlos Pissios, Matthias Blüher, Wifredo Ricart, Manuel Portero-Otin, José Manuel Fernández-Real
Subclinical hypothyroidism is known to be associated with increased serum cholesterol. Since thyroid-stimulating hormone (TSH) exerts an inductor effect on cholesterol biosynthesis, we aimed to investigate the relationship between TSH mRNA and cholesterol metabolism in human adipose tissue (AT). Cross-sectionally, AT TSH-β (TSHB) mRNA was evaluated in 4 independent cohorts in association with serum total and LDL cholesterol, and AT lipidomics. Longitudinally, the effects of statins and of diet and exercise on AT TSHB mRNA were also examined...
June 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28645949/double-blind-randomised-controlled-trial-of-the-independent-and-synergistic-effect-of-spirulina-maxima-with-exercise-isese-on-general-fitness-lipid-profile-and-redox-status-in-overweight-and-obese-subjects-study-protocol
#2
Marco Antonio Hernández-Lepe, José Alberto López-Díaz, Laura Alejandra de la Rosa, Rosa Patricia Hernández-Torres, Abraham Wall-Medrano, Marco Antonio Juarez-Oropeza, José Pedraza-Chaverri, Rene Urquidez-Romero, Arnulfo Ramos-Jiménez
INTRODUCTION: In order to reduce cardiovascular disease risk factors, a healthy diet must include dietary antioxidants from different sources (eg, Spirulina maxima) and regular practice of exercise should be promoted. There is some evidence from animal studies that S. maxima and exercise decrease cardiovascular disease risks factors. However, very few studies have proved the independent or synergistic effect of S. maxima plus exercise in humans. This study attempts to address the independent and synergistic effects in overweight and obese subjects participating in a systematic physical exercise programme at moderate intensity on general fitness, plasma lipid profile and antioxidant capacity...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645653/catalase-overexpression-modulates-metabolic-parameters-in-a-new-stress-less-leptin-deficient-mouse-model
#3
Deborah L Amos, Tanner Robinson, Melissa B Massie, Carla Cook, Alexis Hoffsted, Courtney Crain, Nalini Santanam
Oxidative stress plays a key role in obesity by modifying the function of important biological molecules, thus altering obesogenic pathways such as glucose and lipid signaling. Catalase, is an important endogenous antioxidant enzyme that catabolizes hydrogen peroxide produced by the dismutation of superoxide. Recent studies have shown knockdown of catalase exacerbates insulin resistance and leads to obesity. We hypothesized that overexpressing catalase in an obese mouse will modulate obesogenic pathways and protect against obesity...
June 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28639688/pronounced-limb-and-fibre-type-differences-in-subcellular-lipid-droplet-content-and-distribution-in-elite-skiers-before-and-after-exhaustive-exercise
#4
Han-Chow E Koh, Joachim Nielsen, Bengt Saltin, Hans-Christer Holmberg, Niels Ørtenblad
Although the intramyocellular lipid pool is an important energy store during prolonged exercise, our knowledge concerning its metabolism is still incomplete. Here, quantitative electron microscopy was used to examine subcellular distribution of lipid droplets in type 1 and 2 fibres of the arm and leg muscles before and after one hour of exhaustive exercise. Intermyofibrillar lipid droplets accounted for 85-97% of the total volume fraction, while the subsarcolemmal pool made up 3-15%. Before exercise, the volume fractions of intermyofibrillar and subsarcolemmal lipid droplets were 4- to 6-fold higher in leg than in arm muscles (P < 0...
June 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28639297/autophagy-activation-not-pgc-1%C3%AE-may-mediate-exercise-induced-improvements-in-glucose-handling-during-diet-induced-obesity
#5
Megan E Rosa-Caldwell, Jacob L Brown, David E Lee, Thomas A Blackwell, Kyle W Turner, Lemuel A Brown, Richard A Perry, Wesley S Haynie, Tyrone A Washington, Nicholas P Greene
Prevalence of glucose intolerance is at alarming levels. Efforts to promote mitochondrial biogenesis through PGC-1α to mitigate glucose intolerance have been controversial. However, physical activity remains a primary means to alleviate the condition. PURPOSE: To determine combined effects of muscle-specific overexpression of PGC-1α and physical activity on glucose handling during diet-induced obesity. METHODS: Wild-type (WT, ∼20) and PGC-1α muscle transgenic (MCK-PGC-1α, ∼20) mice were given Western diet (WD) at 8 wks age and allowed to consume food ab libitum throughout the study...
June 21, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28626963/exercise-training-modulates-the-hepatic-renin-angiotensin-system-in-fructose-fed-rats
#6
Eliete Dalla Corte Frantz, Renata Frauches Medeiros, Isabele Gomes Giori, Juliana Bittencourt Silveira Lima, Thais Bento-Bernardes, Thaiane Gadioli Gaique, Caroline Fernandes-Santos, Tiago Fernandes, Edilamar Menezes Oliveira, Carla Paulo Vieira, Carlos Adam Conte-Junior, Karen Jesus Oliveira, Antonio Claudio Lucas da Nóbrega
The renin-angiotensin system (RAS) has been implicated in the development of metabolic syndrome. We investigated whether the hepatic RAS is modulated by exercise training and if this modulation improves the deleterious effects of fructose overload in rats. Male Wistar rats were divided into (n = 8 each) control (CT), exercise control (CT-Ex), high fructose (HFr) and exercise high fructose (HFr-Ex) groups. Fructose-drinking rats received D-fructose (100 g L(-1) ). After two weeks, CT-Ex and HFr-Ex rats were assigned to a treadmill training protocol at moderate-intensity for eight weeks (60 min day(-1) , four days/week)...
June 19, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28625710/effect-of-an-individualised-physical-exercise-program-on-lipid-profile-in-sedentary-patients-with-cardiovascular-risk-factors
#7
Francisco Javier Rubio Pérez, Luis Franco Bonafonte, Daiana Ibarretxe Guerediaga, Maria Pilar Oyon Belaza, Paola Ugarte Peyron
Physical exercise has become in an important tool in the reduction of cardiovascular risk. OBJECTIVES: To evaluate the effectiveness of an unsupervised physical exercise program that on the physical condition and the lipid profile. METHOD: The final sample included 49 sedentary men and women, who were non-smokers, with dyslipidaemia, overweight, and type1 obesity. The 4-month program included walking for 30-60minutes every day, and for three days a week, 30minutes of cycling at an intensity of 40-60% of maximum functional capacity, as well as isometric abdominals and static stretching...
June 15, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28625601/role-of-social-interaction-exercise-diet-and-age-on-developing-and-untreated-diabetes-in-cynomolgus-monkeys
#8
Feng Yue, Guodong Zhang, Jorge E Quintero, Don M Gash, Zhiming Zhang
Type 2 diabetes mellitus is the most common form of diabetes that occurs in both human and nonhuman primates. Although spontaneously diabetic nonhuman primates are used extensively in diabetic related research and are a proven valuable tool for the study of the natural history of diabetes, little is known about the key factors that can cause this metabolic disorder and the preventative measures that could be employed to minimize the consequences of diabetes. Using a model of developing and untreated diabetes, this study describes the effects of housing arrangement (socially group- versus individually single-housed), exercise, diet, age, and sex on fasting plasma glucose, key lipids associated with diabetes, and bodyweight in two large cohorts of nonhuman primates...
June 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28623613/assessment-of-metabolic-flexibility-by-means-of-measuring-blood-lactate-fat-and-carbohydrate-oxidation-responses-to-exercise-in-professional-endurance-athletes-and-less-fit-individuals
#9
Iñigo San-Millán, George A Brooks
BACKGROUND: Increased muscle mitochondrial mass is characteristic of elite professional endurance athletes (PAs), whereas increased blood lactate levels (lactatemia) at the same absolute submaximal exercise intensities and decreased mitochondrial oxidative capacity are characteristics of individuals with low aerobic power. In contrast to PAs, patients with metabolic syndrome (MtS) are characterized by a decreased capacity to oxidize lipids and by early transition from fat to carbohydrate oxidation (FATox/CHOox), as well as elevated blood lactate concentration [La(-)] as exercise power output (PO) increases, a condition termed 'metabolic inflexibility'...
June 16, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28618860/the-effects-of-the-lactobacillus-casei-strain-on-obesity-in-children-a-pilot-study
#10
S Nagata, Y Chiba, C Wang, Y Yamashiro
There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children...
June 16, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28617377/-pharmacological-treatment-of-patients-with-chronic-fatigue-syndrome
#11
O S Glazachev, Е N Dudnik, E E Zagaynaya
AIM: To evaluate the efficacy and safety of human placenta extract - laennec infusions in the treatment of patients with confirmed diagnosis of 'Chronic fatigue syndrome' (CFS). MATERIAL AND METHODS: The study included 38 patients with CFS, randomized into 2 groups: patients of the experimental group (EG, n=24) were treated with 10 intravenous laennec infusions, 4 ml each, 2 times/week, for 5 weeks. The control group (CG) consisted of 14 patients. Treatment efficacy evaluated by the severity of chronic fatigue ('The degree of chronic fatigue' questionnaire), state anxiety, depression and anger (Spilberger test) and quality of life (SF-36v2), exercise tolerance (cardiopulmonary exercise test with gas analysis), blood parameters were assessed before, after, and 5 weeks of follow-up...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28612349/role-of-hydrotherapy-in-the-amelioration-of-oxidant-antioxidant-status-in-rheumatoid-arthritis-patients
#12
Somaiya Mateen, Shagufta Moin, Abdul Q Khan, Atif Zafar, Naureen Fatima, Sumayya Shahzad
AIM: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease. Reactive oxygen species (ROS) are involved in the pathophysiology of RA. Moderate intensity exercises have been reported to have anti-oxidant and anti-inflammatory effects. The aim of this study was to evaluate the effect of hydrotherapy on oxidant-antioxidant status in RA patients. METHODS: Forty RA patients and 30 age- and sex-matched healthy controls were included in this study. RA patients were subdivided into two groups: the first group (n = 20) received treatment with conventional RA drugs, while the second group (n = 20) received hydrotherapy along with the conventional drugs for a period of 12 weeks...
June 14, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28606714/effect-of-physical-exercise-on-brain-and-lipid-metabolism-in-mouse-models-of-multiple-sclerosis
#13
REVIEW
Léo Houdebine, Cristina Anna Gallelli, Marialetizia Rastelli, Nirmal Kumar Sampathkumar, Julien Grenier
Multiple sclerosis (MS) is a central nervous demyelinating disease characterized by cyclic loss and repair of myelin sheaths associated with chronic inflammation and neuronal loss. This degenerative pathology is accompanied by modified levels of oxysterols (oxidative derivatives of cholesterol, implicated in cholesterol metabolism), highlighted in the brain, blood and cerebrospinal fluid of MS patients. The pathological accumulation of such derivatives is thought to participate in the onset and progression of the disease through their implication in inflammation, oxidative stress, demyelination and neurodegeneration...
June 9, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28592573/protocol-for-a-randomised-controlled-trial-of-the-effect-of-dapagliflozin-metformin-and-exercise-on-glycaemic-variability-body-composition-and-cardiovascular-risk-in-prediabetes-the-pre-d-trial
#14
Kristine Færch, Hanan Amadid, Lea Bruhn Nielsen, Mathias Ried-Larsen, Kristian Karstoft, Frederik Persson, Marit Eika Jørgensen
INTRODUCTION: The primary aim of this study is to compare the efficacy of three short-term glucose-lowering interventions (exercise, metformin and dapagliflozin) on glycaemic variability in overweight or obese men and women with elevated diabetes risk (ie, prediabetes, defined as haemoglobin A1c (HbA1c)39-47 mmol/mol / 5.7%-6.4%). The secondary aims are to investigate the effects of the interventions on body composition and cardiometabolic risk factors. METHODS AND ANALYSIS: The Pre-D Trial is an investigator-initiated, randomised, controlled, parallel, open-label, superiority trial...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28590155/cardiopulmonary-exercise-testing-and-metabolic-myopathies
#15
Marshall S Riley, D Paul Nicholls, Christopher B Cooper
Skeletal muscle requires a large increase in its adenosine triphosphate production to meet the energy needs of exercise. Normally, most of this increase in energy is supplied by the aerobic process of oxidative phosphorylation. The main defects in muscle metabolism that interfere with production of adenosine triphosphate are a) disorders of glycogenolysis and glycolysis, which prevent both carbohydrate entering the tricarboxylic acid cycle and the production of lactic acid, b) mitochondrial myopathies where the defect is usually within the electron transport chain, reducing the rate of oxidative phosphorylation and c) disorders of lipid metabolism...
June 7, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28588097/high-intensity-interval-training-and-calorie-restriction-promote-remodeling-of-glucose-and-lipid-metabolism-in-diet-induced-obesity
#16
Rachel A H Davis, Jacob E Halbrooks, Emily Watkins, Gordon Fisher, Gary R Hunter, Tim R Nagy, Eric P Plaisance
Calorie restriction (CR) decreases adiposity, but the magnitude and defense of weight loss is less than predicted due to reductions in total daily energy expenditure (TEE). The purpose of the current investigation was to determine if high-intensity interval training (HIIT) would increase markers of sympathetic activation in white adipose tissue (WAT) and rescue CR-mediated reductions in EE to a greater extent than moderate-intensity aerobic exercise training (MIT). Thirty-two 5-wk old male C57BL/6J mice were placed on ad libitum HFD for 11 weeks followed by randomization to one of four groups (n = 8 per group) for an additional 15 weeks: 1) CON (remain on HFD); 2) CR (25% lower energy intake); 3) CR+HIIT (25% energy deficit created by 12...
June 6, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28584548/the-effect-of-resistance-exercise-on-lipid-profile-of-coronary-artery-disease-patients-a-randomized-clinical-trial
#17
Zahra Salehi, Kobra Salehi, Mahin Moeini, Mehdi Kargarfard, Masoumeh Sadeghi
BACKGROUND: Increased level of blood lipids is one of the risk factors for cardiovascular diseases. Considerable research has done to assess the effects of physical exercises on lipid profile, of which aerobic exercises are the main part of evidence. However, in recent years, resistance exercise has been less investigated. Thus, the present study investigates the effect of resistance exercise on lipid profile in coronary artery disease patients. MATERIALS AND METHODS: This study was a randomized clinical trial...
March 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/28578257/melatonin-supplementation-plus-exercise-behavior-ameliorate-insulin-resistance-hypertension-and-fatigue-in-a-rat-model-of-type-2-diabetes-mellitus
#18
Md Mahbubur Rahman, Han-Sol Kwon, Myung-Jin Kim, Hyeon-Kyu Go, Min-Ho Oak, Do-Hyung Kim
INTRODUCTION: The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Rats were divided into 5 groups namely normal control (NC), T2DM control group (DC), diabetes plus exercise (DE), diabetes plus oral melatonin supplement (DM) and diabetes plus melatonin and exercise (DME) groups. Melatonin was administered orally 5mg/kg twice daily and 40min swimming/day 5days/week were regimented after diabetes induction...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28573134/high-fat-and-fat-enriched-diets-impair-the-benefits-of-moderate-physical-training-in-the-aorta-and-the-heart-in-rats
#19
Cleverson Rodrigues Fernandes, Vinicius Kannen, Karina Magalhães Mata, Fernando Tadeu Frajacomo, Alceu Afonso Jordão Junior, Bianca Gasparotto, Juliana Yumi Sakita, Jorge Elias Junior, Daphne Santoro Leonardi, Fernando Marum Mauad, Simone Gusmão Ramos, Sergio Akira Uyemura, Sergio Britto Garcia
AIM: Millions of people die each year due to cardiovascular disease (CVD). A Western lifestyle not only fuses a significant intake of fat with physical inactivity and obesity but also promotes CVD. Recent evidence suggests that dietary fat intake impairs the benefits of physical training. We investigated whether aerobic training could reverse the adverse effects of a high-fat diet (HFD) on the aorta. Then, we explored whether this type of exercise could reverse the damage to the heart that is imposed by fat-enriched diet (FED)...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28567018/acute-normobaric-hypoxia-increases-post-exercise-lipid-oxidation-in-healthy-males
#20
Liam P Kelly, Fabien A Basset
The primary objective of the current study was to determine the effect of moderate normobaric hypoxia exposure during constant load cycling on post-exercise energy metabolism recorded in normoxia. Indirect calorimetry was used to examine whole body substrate oxidation before, during, 40-60 min post, and 22 h after performing 60 min of cycling exercise at two different fractions of inspired oxygen (FIO2): (i) FIO2 = 0.2091 (normoxia) and (ii) FIO2 = 0.15 (hypoxia). Seven active healthy male participants (26 ± 4 years of age) completed both experimental trials in randomized order with a 7-day washout period to avoid carryover effects between conditions...
2017: Frontiers in Physiology
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