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https://www.readbyqxmd.com/read/27733528/a-third-generation-lipid-emulsion-that-contains-n-3-long-chain-pufas-preserves-retinal-function-in-parenterally-fed-neonatal-piglets
#1
Justine M Turner, Yves Sauvé, Miyoung Suh, Paul W Wales, Pamela Wizzard, Susan Goruk, Catherine J Field
BACKGROUND: Preterm neonates and those with intestinal failure require prolonged parenteral nutrition (PN) during a critical time of early central nervous system maturation. Conventional lipid emulsions fed to preterm neonates lack n-3 (ω-3) long-chain polyunsaturated fatty acids (LC-PUFAs; >20 carbon chain in length). Recently, fish oil lipid emulsions have been developed that provide both n-6 (ω-6) and n-3 LC-PUFAs, precursors of very long-chain PUFAs (VLC-PUFAs; >24 carbon chain in length)...
October 12, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27588242/in-vivo-study-of-hepatic-oxidative-stress-and-mitochondrial-function-in-rabbits-with-severe-hypotension-after-propofol-prolonged-infusion
#2
Sónia Campos, Luís Félix, Carlos Venâncio, Maria de Lurdes Pinto, Francisco Peixoto, Paula Guedes de Pinho, Luís Antunes
In humans, prolonged sedations with propofol or using high doses have been associated with propofol infusion syndrome. The main objective of this study was to evaluate the effects of prolonged high-dose administration of a specific propofol emulsion (Propofol Lipuro) and an improved lipid formulation (SMOFlipid) in liver mitochondrial bioenergetics and oxidative stress of rabbits, comparatively to a saline control. Twenty-one male New Zealand white rabbits were randomly allocated in three groups that were continuously treated for 20 h...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27531257/expression-of-cyp1a1-and-cyp1a2-in-the-liver-and-kidney-of-rabbits-after-prolonged-infusion-of-propofol
#3
Sónia P Campos, Maria de Lurdes Pinto, Gabriela Gomes, Paula Guedes de Pinho, Joaquim A Monteiro, Luis M Félix, Paula S Branco, Luísa M Ferreira, Luís M Antunes
BACKGROUND: Propofol biotransformation occurs in the liver via hydroxylation by CYP450 enzymatic complex and by glucuronidation, however extra-hepatic metabolism has also been described. OBJECTIVES: To better understand the metabolic pathways involved in propofol biotransformation, the expression of CYP1A1, CYP1A2, the enzymatic and non-enzymatic antioxidant activity and the amount of propofol and its non-conjugated metabolites were investigated. METHODS: Twenty-one NewZealand rabbits were allocated into three groups continuously treated for 20h...
October 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27513481/-not-available
#4
Fátima Martínez-Lozano Aranaga, Paula Palacios Vales, Juana María Serrano Navarro, Carmen Caballero Requejo, María Jesús Gómez Ramos, Carmen Sánchez Álvarez
Introducción: la composición lipídica de las fórmulas de nutrición parenteral (NP) se postula como posible factor de evolución clínica.Objetivo: evaluar las diferencias en eficacia y seguridad de dos emulsiones lipídicas en NP.Material y métodos: estudio clínico prospectivo de pacientes posquirúrgicos sometidos a NP durante más de 7 días en un periodo de 2 años. Se administraron de forma indistinta 2 tipos de emulsiones lipídicas: enriquecida con ácidos grasos omega 3 (SMOFlipid Fresenius Kabi®) o con ácido oleico omega 9 (Clinoleic Baxter®)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27495286/lipid-emulsion-formulation-of-parenteral-nutrition-affects-intestinal-microbiota-and-host-responses-in-neonatal-piglets
#5
Celeste M Lavallee, Jayden A R MacPherson, Mi Zhou, Yanhua Gao, Pamela R Wizzard, Paul W Wales, Justine M Turner, Benjamin P Willing
BACKGROUND: Total parenteral nutrition (TPN) is a cause of intestinal microbial dysbiosis and impaired gut barrier function. This may contribute to life-threatening parenteral nutrition-associated liver disease and sepsis in infants. We compared the effects of a lipid emulsion containing long-chain ω-3 polyunsaturated fatty acids (PUFAs; SMOFlipid) and a predominantly ω-6 PUFA emulsion (Intralipid) on microbial composition and host response at the mucosal surface. MATERIALS AND METHODS: Neonatal piglets were provided isocaloric, isonitrogenous TPN for 14 days versus sow-fed (SF) controls...
August 5, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27474222/multi-omic-profiles-of-hepatic-metabolism-in-tpn-fed-preterm-pigs-administered-new-generation-lipid-emulsions
#6
Gregory Guthrie, Madhulika Kulkarni, Hester Vlaardingerbroek, Barbara Stoll, Kenneth Ng, Camilia Martin, John Belmont, Darryl Hadsell, William Heird, Christopher B Newgard, Oluyinka Olutoye, Johannes van Goudoever, Charlotte Lauridsen, Xingxuan He, Edward H Schuchman, Douglas Burrin
We aimed to characterize the lipidomic, metabolomic, and transcriptomic profiles in preterm piglets administered enteral (ENT) formula or three parenteral lipid emulsions [parenteral nutrition (PN)], Intralipid (IL), Omegaven (OV), or SMOFlipid (SL), for 14 days. Piglets in all parenteral lipid groups showed differential organ growth versus ENT piglets; whole body growth rate was lowest in IL piglets, yet there were no differences in either energy expenditure or (13)C-palmitate oxidation. Plasma homeostatic model assessment of insulin resistance demonstrated insulin resistance in IL, but not OV or SL, compared with ENT...
September 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27444453/-not-available
#7
Fátima Martínez-Lozano Aranaga, Paula Palacios Vales, Juana María Serrano Navarro, Carmen Caballero Requejo, María Jesús Gómez Ramos, Carmen Sánchez Álvarez
Introducción: la composición lipídica de las fórmulas de nutrición parenteral (NP) se postula como posible factor de evolución clínica.Objetivo: evaluar las diferencias en eficacia y seguridad de dos emulsiones lipídicas en NP.Material y métodos: estudio clínico prospectivo de pacientes posquirúrgicos sometidos a NP durante más de 7 días en un periodo de 2 años. Se administraron de forma indistinta 2 tipos de emulsiones lipídicas: enriquecida con ácidos grasos omega 3 (SMOFlipid Fresenius Kabi®) o con ácido oleico omega 9 (Clinoleic Baxter®)...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27348965/in-vitro-detection-of-mannan-and-galactomannan-in-components-of-total-parenteral-nutrition-tpn
#8
H Knoth, D Maywald, W Walter
Detection of Candida mannan and Aspergillus galactomannan in serum with the Platelia enzyme immunoassay is applied for diagnosing invasive fungal infections. High risk patients for invasive fungal infections are often receiving parenteral nutrition. It is important to know whether false-positive Platelia test results occur during total parenteral nutrition. Studies to false-positivity in intravenous feeding solutions lack so that we start an in-vitro investigation. We used two different enzyme immunoassays to test the feeding solutions...
May 2016: Die Pharmazie
https://www.readbyqxmd.com/read/27002321/apolipoprotein-a-ii-plus-lipid-emulsion-enhance-cell-growth-via-sr-b1-and-target-pancreatic-cancer-in-vitro-and-in-vivo
#9
Sohel M Julovi, Aiqun Xue, Thao N Thanh LE, Anthony J Gill, Jerikho C Bulanadi, Mili Patel, Lynne J Waddington, Kerry-Anne Rye, Minoo J Moghaddam, Ross C Smith
BACKGROUND: Apolipoprotein A-II (ApoA-II) is down regulated in the sera of pancreatic ductal adenocarcinoma (PDAC) patients, which may be due to increase utilization of high density lipoprotein (HDL) lipid by pancreatic cancer tissue. This study examined the influence of exogenous ApoA-II on lipid uptake and cell growth in pancreatic cancer (PC) both in vitro and in vivo. METHODS: Cryo transmission electron microscopy (TEM) examined ApoA-II's influence on morphology of SMOFLipid emulsion...
2016: PloS One
https://www.readbyqxmd.com/read/26917987/effects-of-acidification-and-alkalinization-on-the-lipid-emulsion-mediated-reversal-of-toxic-dose-levobupivacaine-induced-vasodilation-in-the-isolated-rat-aorta
#10
Seong-Ho Ok, Won Ho Kim, Jongsun Yu, Youngju Lee, Mun-Jeoung Choi, Dong Hoon Lim, Yeran Hwang, Yeon A Kim, Ju-Tae Sohn
The goal of this in vitro study was to examine the effects of pre-acidification and pre-akalinization on the lipid emulsion-mediated reversal of toxic dose levobupivacaine-induced vasodilation in isolated rat aorta. Isolated aortic rings with and without the nitric oxide synthase inhibitor N(ω)-nitro-L-arginine methyl ester (L-NAME) were exposed to four types of Krebs solution (pH 7.0, 7.2, 7.4, and 7.6), followed by the addition of 60 mM potassium chloride. When the toxic dose of levobupivacaine (3 × 10(-4) M) produced a stable and sustained vasodilation in the isolated aortic rings that were precontracted with 60 mM potassium chloride, increasing lipid emulsion concentrations (SMOFlipid(®): 0...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/26838529/preventing-the-progression-of-intestinal-failure-associated-liver-disease-in-infants-using-a-composite-lipid-emulsion-a-pilot-randomized-controlled-trial-of-smoflipid
#11
Ivan R Diamond, Robert C Grant, Paul B Pencharz, Nicole de Silva, Brian M Feldman, Peter Fitzgerald, David Sigalet, Bryan Dicken, Justine Turner, Valerie Marchand, Simon C Ling, Aideen M Moore, Yaron Avitzur, Paul W Wales
BACKGROUND: To examine whether SMOFlipid prevents progression of intestinal failure-associated liver disease (IFALD) in parenteral nutrition (PN)-dependent infants with early IFALD (conjugated bilirubin 17-50 µmol/L, 1-3 mg/dL). STUDY DESIGN: Pilot multicenter blinded randomized controlled trial comparing SMOFlipid with Intralipid. Patients received the trial lipid for up to 12 weeks, unless they achieved full enteral tolerance sooner. The primary clinical outcome was the serum conjugated bilirubin...
February 2, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/26698410/pediatric-parenteral-nutrition-associated-liver-disease-and-cholestasis-novel-advances-in-pathomechanisms-based-prevention-and-treatment
#12
REVIEW
Giuseppe Orso, Claudia Mandato, Claudio Veropalumbo, Nicola Cecchi, Alfredo Garzi, Pietro Vajro
Parenteral nutrition constitutes a life-saving therapeutic tool in patients unable to ingest/absorb oral or enteral delivered nutrients. Liver function tests abnormalities are a common therapy-related complication, thus configuring the so-called Parenteral Nutrition Associated Liver Disease (PNALD) or cholestasis (PNAC). Although the damage is frequently mild, and resolves after discontinuation of parenteral nutrition, in some cases it progresses into cirrhotic changes, especially in neonates and infants. We present a literature review focusing on the pathogenetic mechanisms-driven prevention and therapies for the cases where parenteral nutrition cannot be discontinued...
March 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/25837680/liver-disease-systemic-inflammation-and-growth-using-a-mixed-parenteral-lipid-emulsion-containing-soybean-oil-fish-oil-and-medium-chain-triglycerides-compared-with-soybean-oil-in-parenteral-nutrition-fed-neonatal-piglets
#13
Justine M Turner, Jessica Josephson, Catherine J Field, Pamela R Wizzard, Ronald O Ball, Paul B Pencharz, Paul W Wales
BACKGROUND: The optimal parenteral lipid emulsion for neonates should reduce the risk of intestinal failure-associated liver disease and inflammation, while supporting growth and development. This could be best achieved by balanced content of ω-6 and ω-3 polyunsaturated fatty acids (PUFAs). Using a neonatal piglet model of parenteral nutrition (PN), we compared a 100% soy oil-based emulsion (ω-6:ω-3 PUFA: 7:1) with a mixed lipid emulsion comprising 30% soy oil, 30% medium-chain triglycerides, 25% olive oil, and 15% fish oil (ω-6:ω-3 PUFA: approximately 2...
September 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25767334/the-olive-oil-based-lipid-clinoleic-blocks-leukocyte-recruitment-and-improves-survival-during-systemic-inflammation-a-comparative-in-vivo-study-of-different-parenteral-lipid-emulsions
#14
Kirsten Buschmann, Johannes Poeschl, Natascha Braach, Hannes Hudalla, Navina Kuss, David Frommhold
Although fish oil-based and olive oil-based lipid emulsions have been shown to exert anti-inflammatory functions, the immunomodulating properties of lipids are still controversial. Therefore, we investigated the anti-inflammatory effect of three different parenterally administered lipid emulsions in vivo: olive oil-based Clinoleic, fish oil-based Smoflipid, and soybean oil-based Lipofundin. We observed leukocyte recruitment in inflamed murine cremaster muscle using intravital microscopy and survival in a murine model of LPS-induced systemic inflammation and analyzed expression of leukocyte and endothelial adhesion molecules...
2015: Mediators of Inflammation
https://www.readbyqxmd.com/read/25685054/tocopherol-and-tocotrienol-homologs-in-parenteral-lipid-emulsions
#15
Zhidong Xu, Kevin A Harvey, Thomas M Pavlina, Gary P Zaloga, Rafat A Siddiqui
: Parenteral lipid emulsions, which are made of oils from plant and fish sources, contain different types of tocopherols and tocotrienols (vitamin E homologs). The amount and types of vitamin E homologs in various lipid emulsions vary considerably and are not completely known. The objective of this analysis was to develop a quantitative method to determine levels of all vitamin E homologs in various lipid emulsions. An HPLC system was used to measure vitamin E homologs using a Pinnacle DB Silica normal phase column and an isocratic, n-hexane:1,4 dioxane (98:2) mobile phase...
January 2015: European Journal of Lipid Science and Technology: EJLST
https://www.readbyqxmd.com/read/25560679/reversal-of-intestinal-failure-associated-liver-disease-by-switching-from-a-combination-lipid-emulsion-containing-fish-oil-to-fish-oil-monotherapy
#16
Sanghoon Lee, Hyo Jung Park, Jihye Yoon, Seul Hee Hong, Chae-Youn Oh, Suk-Koo Lee, Jeong-Meen Seo
Intestinal failure-associated liver disease (IFALD) is a serious complication of parenteral nutrition (PN). Studies have shown that the amount and content of intravenous lipid emulsions (LEs) used is closely related to the development of IFALD. We report 2 cases of IFALD reversed by switching from a combination lipid emulsion containing fish oil to fish oil monotherapy (Omegaven; Fresenius Kabi Austria Gmbh, Graz, Austria). Patients initially received PN containing SMOFlipid 20% (SMOF; Fresenius Kabi Austria Gmbh, Graz, Austria), 2...
March 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25137266/finding-new-solutions-in-pediatric-parenteral-admixtures-how-to-improve-quality-and-to-deal-with-shortages
#17
Dorota Watrobska-Swietlikowska, Anna Kwidzynska, Agnieszka Szlagatys-Sidorkiewicz, Malgorzata Sznitowska, Stanislaw Klek
INTRODUCTION: Pediatric parenteral nutrition enables normal growth even of preterm infants. Those children require, however, tailored parenteral nutrition and the creation of such can be challenging due to the risk of instability and shortages. OBJECTIVE: Prototypical parenteral admixtures were created using different calcium salts (organic and inorganic) and different lipid emulsions and tested for stability. 36 of parenteral admixtures containing two types of calcium salts: chloride or gluconolactobionate and different lipid emulsions (SMOFlipid® or Lipofundin MCT/LCT®) were under investigation...
2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/25038627/lipid-emulsions-differentially-affect-lps-induced-acute-monocytes-inflammation-in-vitro-effects-on-membrane-remodeling-and-cell-viability
#18
Julie Boisramé-Helms, Xavier Delabranche, Andrey Klymchenko, Jocelyne Drai, Emilie Blond, Fatiha Zobairi, Yves Mely, Michel Hasselmann, Florence Toti, Ferhat Meziani
The aim of this study was to assess how lipid emulsions for parenteral nutrition affect lipopolysaccharide (LPS)-induced acute monocyte inflammation in vitro. An 18 h long LPS induced human monocyte leukemia cell stimulation was performed and the cell-growth medium was supplemented with three different industrial lipid emulsions: Intralipid(®), containing long-chain triglycerides (LCT--soybean oil); Medialipid(®), containing LCT (soybean oil) and medium-chain triglycerides (MCT--coconut oil); and SMOFlipid(®), containing LCT, MCT, omega-9 and -3 (soybean, coconut, olive and fish oils)...
November 2014: Lipids
https://www.readbyqxmd.com/read/24314586/the-influence-of-fish-oil-lipid-emulsions-on-retinopathy-of-prematurity-in-very-low-birth-weight-infants-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Serdar Beken, Dilek Dilli, Nurdan Dinlen Fettah, Emrah Utku Kabataş, Ayşegül Zenciroğlu, Nurullah Okumuş
OBJECTIVE: To compare the effect of two lipid emulsions on the development of retinopathy of prematurity in very low birth weight infants. DESIGN: Randomized controlled study. PATIENTS AND METHODS: Eighty very low birth weight infants receiving parenteral nutrition from the first day of life were evaluated. One of the two lipid emulsions were used in the study infants: Group 1 (n=40) received fish-oil based lipid emulsion (SmofLipid®) and Group 2 (n=40) soybean oil based lipid emulsion (Intralipid®)...
January 2014: Early Human Development
https://www.readbyqxmd.com/read/24285251/randomized-clinical-trial-of-new-intravenous-lipid-smoflipid-20-versus-medium-chain-triglycerides-long-chain-triglycerides-in-adult-patients-undergoing-gastrointestinal-surgery
#20
RANDOMIZED CONTROLLED TRIAL
Ming-Hsun Wu, Ming-Yang Wang, Chin-Yao Yang, Min-Liang Kuo, Ming-Tsan Lin
BACKGROUND: SMOFlipid 20% is intravenous lipid emulsion (ILE) containing long-chain triglycerides (LCT), medium-chain triglycerides (MCT), olive oil, and fish oil as a mixed emulsion containing α-tocopherol. The aim was to assess the efficacy of this new ILE in gastrointestinal surgery compared with MCT/LCT. METHODS: In this prospective study, 40 patients were randomized to SMOFlipid 20% or MCT/LCT (Lipovenoes 20%) group. Clinical and biochemistry data were collected...
September 2014: JPEN. Journal of Parenteral and Enteral Nutrition
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