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https://www.readbyqxmd.com/read/29656582/hyperactive-cyclic-motor-activity-in-the-distal-colon-after-colonic-surgery-as-defined-by-high-resolution-colonic-manometry
#1
R Vather, G O'Grady, A Y Lin, P Du, C I Wells, D Rowbotham, J Arkwright, L K Cheng, P G Dinning, I P Bissett
BACKGROUND: Recovery after colonic surgery is invariably delayed by disturbed gut motility. It is commonly assumed that colonic motility becomes quiescent after surgery, but this hypothesis has not been evaluated rigorously. This study quantified colonic motility through the early postoperative period using high-resolution colonic manometry. METHODS: Fibre-optic colonic manometry was performed continuously before, during and after surgery in the left colon and rectum of patients undergoing right hemicolectomy, and in healthy controls...
April 14, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29652748/the-scintigraphic-biodistribution-and-histopathological-evaluation-of-the-effect-of-experimental-131i-administration-on-the-gastrointestinal-system-and-the-demonstration-of-the-na-i-symporter-by-immunohistochemistry-in-rats
#2
Rahsan Yilmaz, Nihat Yumusak, Murat Sadic, Hasan I Atilgan, Meliha Korkmaz, Faruk Bozkaya
OBJECTIVE: The aim of this study was to investigate histopathological changes and biodistribution of iodine-131 (I) in the gastrointestinal system (GIS) and also Na/I Symporter (NIS) presence by immunohistochemically in the experimental treatment of rats with radioactive iodine (RAI). MATERIALS AND METHODS: Rats were divided into experimental and control groups as random early group 2 (24 h), intermediate group 3 (3 weeks), and late period group 4 (3 months). Experimental groups were administered 100 MBq (∼3 mCi, 12 mCi/kg) by orogastric route with orogastric tube...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29651274/identification-of-unequally-represented-founder-viruses-among-tissues-in-very-early-siv-rectal-transmission
#3
Jian Chen, Yanqin Ren, Lance Daharsh, Lu Liu, Guobin Kang, Qingsheng Li, Qiang Wei, Yanmin Wan, Jianqing Xu
Characterizing the transmitted/founder (T/F) viruses of multi-variant SIV infection may shed new light on the understanding of mucosal transmission. We intrarectally inoculated six Chinese rhesus macaques with a single high dose of SIVmac251 (3.1 × 104 TCID50 ) and obtained 985 full-length env sequences from multiple tissues at 6 and 10 days post-infection by single genome amplification (SGA). All 6 monkeys were infected with a range of 2 to 8 T/F viruses and the dominant variants from the inoculum were still dominant in different tissues from each monkey...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29650925/-a-case-of-colon-cancer-with-brain-liver-and-lung-metastasis-successfully-treated-with-bevacizumab-plus-xelox-therapy
#4
Tomokazu Tokoro, Keishi Nakamura, Atsushi Hirose, Shinichi Nakanuma, Kohichi Okamoto, Jun Kinoshita, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
The patient was a 57-year-old woman. Preclinical examination of malignant lymphoma revealed 0-I sp type of early rectal cancer in the upper rectum, 20 cm from the anal margin. Endoscopic mucosal resection was performed and positive deep margins were pathologically diagnosed. Additional intestinal resection with lymph node dissection was deemed necessary, but ABVD therapy was initiated because the clinical stage of the malignant lymphoma was Stage III b or higher. Two months after detecting elevated CEA, S8 liver metastasis was pointed out, and examination of weakness of the right upper limb revealed nodular, multifocal brain metastasis...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644052/environmental-colonization-and-onward-clonal-transmission-of-carbapenem-resistant-acinetobacter-baumannii-crab-in-a-medical-intensive-care-unit-the-case-for-environmental-hygiene
#5
Deborah H L Ng, Kalisvar Marimuthu, Jia Jun Lee, Wei Xin Khong, Oon Tek Ng, Wei Zhang, Bee Fong Poh, Pooja Rao, Maya Devi Rajinder Raj, Brenda Ang, Partha Pratim De
Background: In May 2015, we noticed an increase in carbapenem-resistant Acinetobacter baumannii (CRAB) infections in the Medical Intensive Care Unit (MICU). To investigate this, we studied the extent of environmental contamination and subsequent onward clonal transmission of CRAB. Methods: We conducted a one-day point prevalence screening (PPS) of the patients and environment in the MICU. We screened patients using endotracheal tube aspirates and swabs from nares, axillae, groin, rectum, wounds, and exit sites of drains...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29644045/massive-chronic-irreducible-rectal-prolapse-successfully-treated-with-altemeier-s-procedure
#6
Noriaki Koizumi, Hiroki Kobayashi, Kanehisa Fukumoto
The guideline for the treatment of rectal prolapse recommends that surgeons select appropriate surgical procedures individually based on each patient's overall status. However, in cases of irreducible or incarcerated rectal prolapse, surgical options are quite limited. Here we present a case of an elderly woman with massive chronic irreducible rectal prolapse. An 87-year-old woman presented to our hospital with a complaint of massive rectal prolapse. The prolapsed rectum was over 20 cm long, and completely irreducible...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29628185/revisiting-colorectal-cancer-animal-model-an-improved-metastatic-model-for-distal-rectosigmoid-colon-carcinoma
#7
Rui Caetano-Oliveira, Marcos António Gomes, Ana Margarida Abrantes, Edgar Tavares-Silva, Marco Carvalho Oliveira, Mafalda Laranjo, Débora Basílio Queirós, João Casalta-Lopes, Salomé Pires, Lina Carvalho, Rosa Gouveia, Paulo Rodrigues Santos, Denise Gonçalves Priolli, José Guilherme Tralhão, Maria Filomena Botelho
Colorectal cancer (CRC) is the second most frequent and fatal cancer in Western countries. Understanding its biology with different incidence along the colon and rectum, genetic profile and how these factors contribute to local/distant progression, has been hampered by the lack of a suitable CRC model. We report a reproducible model, using human CRC cell lines (CL) (WiDr, LS1034, C2BBe1) injected (1 × 107 cells/animal) in RNU rats (n = 55) which underwent cecostomy and descending colostomy with mucosal-cutaneous fistula of the sigmoid colon...
March 13, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29627309/effect-of-primary-tumor-location-on-second-or-later-line-treatment-outcomes-in-patients-with-ras-wild-type-metastatic-colorectal-cancer-and-all-treatment-lines-in-patients-with-ras-mutations-in-four-randomized-panitumumab-studies
#8
Nele Boeckx, Reija Koukakis, Ken Op de Beeck, Christian Rolfo, Guy Van Camp, Salvatore Siena, Josep Tabernero, Jean-Yves Douillard, Thierry André, Marc Peeters
BACKGROUND: The primary tumor location has a prognostic impact in metastatic colorectal cancer (mCRC). We report the results from retrospective analyses assessing the effect of tumor location on prognosis and efficacy of second- and later-line panitumumab treatment in patients with RAS wild-type (WT) mCRC and on prognosis in all lines of treatment in patients with RAS mutant (MT) mCRC. PATIENTS AND METHODS: RAS WT data (n = 483) from 2 randomized phase III panitumumab trials (ClinicalTrials...
March 8, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29626223/effect-of-temperature-and-vector-nutrition-on-the-development-and-multiplication-of-trypanosoma-rangeli-in-rhodnius-prolixus
#9
Roberta Carvalho Ferreira, Cínthia Firmo Teixeira, Vinícius Fernandes A de Sousa, Alessandra A Guarneri
Trypanosoma rangeli is a protozoan parasite that infects mammals and triatomines, causing different levels of pathogenicity in its invertebrate vectors, particularly those from the genus Rhodnius. We have recently shown that temperature can modulate T. rangeli growth during in vitro culture, as well as its in vivo pathogenicity to R. prolixus. In the present study, we investigated colonization of R. prolixus by T. rangeli and assessed the role of temperature and vector nutrition on parasite development and multiplication...
April 6, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29622466/comparative-molecular-analysis-of-gastrointestinal-adenocarcinomas
#10
Yang Liu, Nilay S Sethi, Toshinori Hinoue, Barbara G Schneider, Andrew D Cherniack, Francisco Sanchez-Vega, Jose A Seoane, Farshad Farshidfar, Reanne Bowlby, Mirazul Islam, Jaegil Kim, Walid Chatila, Rehan Akbani, Rupa S Kanchi, Charles S Rabkin, Joseph E Willis, Kenneth K Wang, Shannon J McCall, Lopa Mishra, Akinyemi I Ojesina, Susan Bullman, Chandra Sekhar Pedamallu, Alexander J Lazar, Ryo Sakai, Vésteinn Thorsson, Adam J Bass, Peter W Laird
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE...
April 2, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29619053/dosimetric-analysis-of-the-effects-of-the-bladder-volume-on-organs-at-risk-oar-in-high-dose-rate-intracavitary-brachytherapy-in-carcinoma-cervix-an-institutional-study
#11
Ashutosh Das Sharma, Jyoti Poddar, U Suryanarayan K, Sonal Patel Shah, Ankita Parikh, Vimesh Mehta, Med Phys, Tarun Kumar, Med Phys
Purpose: The purpose of this study was to establish a dosimetric correlation between the bladder volume and its effects on the dose received by the organs at risk (OARs) (urinary bladder, rectum, and sigmoid) during computed tomography (CT)-guided high-dose-rate (HDR) brachytherapy in carcinoma cervix, and to determine an optimum bladder volume to limit the dose to OARs. Material and methods: Seventy-five intracavitary applications in patients of carcinoma cervix (stage IIB, IIIA, IIIB, IVA) treated with external beam radiotherapy with concurrent chemotherapy followed by CT-based HDR intracavitary brachytherapy (tandem and ovoid type) at our institute between July 2014 to January 2016 were studied...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29614586/-the-colonoscopic-characteristics-of-colorectal-endometriosis-a-single-centered-retrospective-study
#12
S Y Zhang, J Li, Q Wang, Y L Feng, Q W Jiang, F Jiang, G J Fei, F Yao, L M Zhu, J M Qian, A M Yang
Objective: To reinforce the awareness of colorectal endometriosis (EM) in colonoscopy examination. Methods: Patients diagnosed as colorectal EM at Peking Union Medical College Hospital between February 2002 and February 2017 were enrolled in this study. The clinical characteristics and endoscopic features of EM lesions were summarized and compared between pathologically positive group and negative group. Results: A total of 34 cases were included with average age of (38.3±8.9) years old. All EM lesions located within rectum and sigmoid colon...
April 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29610512/risk-of-interval-cancer-in-fecal-immunochemical-test-screening-significantly-higher-during-the-summer-months-results-from-the-national-cancer-screening-program-in-korea
#13
Jae Myung Cha, Mina Suh, Min Seob Kwak, Na Young Sung, Kui Son Choi, Boyoung Park, Jae Kwan Jun, Sang-Hyun Hwang, Do-Hoon Lee, Byung Chang Kim, You Kyoung Lee, Dong Soo Han
OBJECTIVES: This study aimed to evaluate the impact of seasonal variations in climate on the performance of the fecal immunochemical test (FIT) in screening for colorectal cancer in the National Cancer Screening Program in Korea. METHODS: Data were extracted from the National Cancer Screening Program databases for participants who underwent FIT between 2009 and 2010. We compared positivity rates, cancer detection rates, interval cancer rates, positive predictive value, sensitivity, and specificity for FIT during the spring, summer, fall, and winter seasons in Korea...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29606350/analysis-of-quality-indicators-for-colorectal-cancer-surgery-in-units-accredited-by-the-spanish-association-of-coloproctology
#14
Fernando de la Portilla, Sergio Builes, Alejandra García-Novoa, Eloy Espín, Esther Kreisler, José María Enríquez-Navascues, Sebastiano Biondo, Antonio Codina
INTRODUCTION: Currently, there is growing interest in analyzing the results from surgical units and the implementation of quality standards in order to identify good healthcare practices. Due to this fact, the Spanish Association of Coloproctology (AECP) has developed a unit accreditation program that contemplates basic standards. The aim of this article is to evaluate and analyze the specific quality indicators for the surgical treatment of colorectal cancer, established by the program...
March 29, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29606130/proteasome-inhibitors-modulate-anticancer-and-anti-proliferative-properties-via-nf-kb-signaling-and-ubiquitin-proteasome-pathways-in-cancer-cell-lines-of-different-organs
#15
Asaf A Qureshi, Eleanor G Zuvanich, Dilshad A Khan, Shahida Mushtaq, Neerupma Silswal, Nilofer Qureshi
BACKGROUND: Cancer is second most common cause of death in the United State. There are over 100 different types of cancer associated with different human organs, predominantly breast, liver, pancreas, prostate, colon, rectum, lung, and stomach. We have recently reported properties of pro-inflammatory (for treatment of various types of cancers), and anti-inflammatory (for cardiovascular disease and diabetes) compounds. The major problem associated with development of anticancer drugs is their lack of solubility in aqueous solutions and severe side effects in cancer patients...
April 2, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29594445/the-prognostic-implications-of-primary-tumor-location-on-recurrence-in-early-stage-colorectal-cancer-with-no-associated-risk-factors
#16
Sung Il Kang, Duck-Woo Kim, Yoonjin Kwak, Hye-Seung Lee, Min Hyun Kim, Myung Jo Kim, Heung-Kwon Oh, Sung-Bum Kang
PURPOSE: Recently, several reports have suggested that tumor location serves as a prognostic biomarker in advanced colorectal cancer. However, the prognostic implication of tumor location in patients with early-stage colorectal cancer remains unclear. This study was aimed to examine the prognostic implication of tumor location in patients with early-stage colorectal cancer. METHODS: Patients with stage I and low-risk stage II colorectal cancer, treated with radical surgery in a hospital setting between May 2003 and September 2014, were retrospectively reviewed...
March 28, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29588261/complete-penile-duplication-with-structurally-normal-penises-a-case-report
#17
Ahsen Karagözlü Akgül, Murat Uçar, Fatih Çelik, İrfan Kırıştıoğlu, Nizamettin Kılıç
BACKGROUND: Diphallia is a very rare anomaly and seen once in every 5.5 million live births. True diphallia with normal penile structures is extremely rare (1,2,3,4,5,6,7). We present the surgical management of a 4-year-old patient with complete penile duplication without any penile or urethral pathology. CASE REPORT: The patient's first physical examination revealed complete penile duplication, urine flow from both penises, meconium flow from right urethra, and anal atresia...
March 28, 2018: Balkan Medical Journal
https://www.readbyqxmd.com/read/29587771/treatment-of-intraoperatively-detected-peritoneal-carcinomatosis-of-colorectal-origin-with-cytoreductive-surgery-and-intraperitoneal-chemotherapy
#18
Aras Emre Canda, Cigdem Arslan, Cem Terzi, Selman Sokmen, Tugba Yavuzsen, Sevda Ozkardesler, Mehtat Unlu, Funda Obuz, Mehmet Fuzun
BACKGROUND: Diagnosis of peritoneal carcinomatosis (PC) may be missed by preoperative imaging. We are presenting our experience with incidentally detected PC of colorectal origin treated with cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) at the same operation. METHODS: Between January 2010 and September 2016, 19 patients underwent CRS and IPC due to incidentally detected PC of colorectal origin. Data were analyzed from a prospectively collected database...
March 27, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29582162/low-adherence-to-the-western-and-high-adherence-to-the-mediterranean-dietary-patterns-could-prevent-colorectal-cancer
#19
Adela Castelló, Pilar Amiano, Nerea Fernández de Larrea, Vicente Martín, Maria Henar Alonso, Gemma Castaño-Vinyals, Beatriz Pérez-Gómez, Rocío Olmedo-Requena, Marcela Guevara, Guillermo Fernandez-Tardon, Trinidad Dierssen-Sotos, Cristobal Llorens-Ivorra, Jose María Huerta, Rocío Capelo, Tania Fernández-Villa, Anna Díez-Villanueva, Carmen Urtiaga, Jesús Castilla, Jose Juan Jiménez-Moleón, Víctor Moreno, Verónica Dávila-Batista, Manolis Kogevinas, Nuria Aragonés, Marina Pollán
PURPOSE: To assess if the associations found between three previously identified dietary patterns with breast, prostate and gastric cancer are also observed for colorectal cancer (CRC). METHODS: MCC-Spain is a multicase-control study that collected information of 1629 incident cases of CRC and 3509 population-based controls from 11 Spanish provinces. Western, Prudent and Mediterranean data-driven dietary patterns-derived in another Spanish case-control study-were reconstructed in MCC-Spain...
March 26, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29581763/cancer-survival-in-patients-from-a-hospital-based-cancer-registry-china
#20
Jian-Guo Chen, Hai-Zhen Chen, Jian Zhu, Yan-Lei Yang, Yong-Hui Zhang, Pei-Xin Huang, Yong-Sheng Chen, Chao-Yong Zhu, Li-Ping Yang, Kang Shen, Fu-Lin Qiang, Gao-Ren Wang
Purpose: There are few reports on survival rate analysis from hospital-based cancer registries (HBCR) in China, although the National Center of Cancer Registry of China has launched such an effort with the mission to expand the scope of registration and follow-up. Our study aimed to evaluate survival and outcomes of cancer patients from a HBCR in eastern China. Methods: Active and passive follow-up methods were used to obtain information on survival status for all patients from Qidong City and Haimen City in the databases of our hospital-based registrations from 2002 to 2014...
2018: Journal of Cancer
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