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https://www.readbyqxmd.com/read/29924451/satb2-is-a-supplementary-immunohistochemical-marker-to-cdx2-in-the-diagnosis-of-colorectal-carcinoma-metastasis-in-an-unknown-primary
#1
Parag Deepak Dabir, Hans Svanholm, Jens Johannes Christiansen
CDX2 is routinely used for identifying gastrointestinal origin of metastatic adenocarcinomas; but a high percentage of other carcinomas also show positivity with this antibody. SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the primary site could be identified as 'colon-rectum'. Metastasis in 67 liver biopsies, 108 lymph nodes from resection specimens and 36 serous effusions was analyzed retrospectively...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29922640/segmental-colitis-associated-diverticulosis-a-possible-diagnosis-in-teenagers
#2
Cristina O Mǎrginean, Lorena E Meliţ, Maria O Mǎrginean
Segmental colitis associated with diverticulosis (SCAD) is manifested by active chronic inflammation of the colonic segments affected by diverticulosis, luminal-mucosal inflammation, independent of the presence of inflammation within and/or around the diverticula, and it usually spares the rectum. We present the case of a 15-year-old female admitted to our clinic due to lower digestive hemorrhage and abdominal pain in the previous week, associated with fever 1 day prior to admission. The patient had pallor, painful abdomen upon palpation, accelerated bowel movements, and macroscopic evidence of blood in the stools...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29915904/the-influence-of-tumour-site-on-prognosis-in-metastatic-colorectal-carcinomas-with-primary-tumour-resection
#3
Susanne Merkel, Vera S Schellerer, Axel Wein, Sabine Semrau, Carol Geppert, Jonas Göhl, Werner Hohenberger, Klaus Weber, Robert Grützmann
PURPOSE: The aim of our study was to compare the characteristics and prognosis between right- and left-sided metastatic colorectal carcinomas. METHODS: Data from 937 patients with stage IV colorectal carcinomas (synchronous distant metastasis) who had a resection of the primary tumour between 1985 and 2014 were analysed. Carcinomas in the caecum to transverse colon were defined as right-sided (n = 250; 26.7%). They were compared to tumours located from the splenic flexure to the rectum categorised as left-sided (n = 687; 73...
June 18, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29915739/awareness-of-colorectal-cancer-among-public-in-asir-region
#4
Mohammad Nassir Al-Sharif, Khalid Ali Fayi, Abdulsalam Ali Alobaidi, Bader Awadh Alshamrani
Introduction: Colorectal cancer (CRC) has different forms of colon cancer or rectal cancer. CRCs are often considered together because they possess many similar features. A severe form of the disease with higher mortality rate increases with increase in age. The most common CRC risk factors include smoking, diabetes, and obesity. This study aims to evaluate the awareness of CRC in a random population of Asir region and to identify the subpopulation that can be recipients of awareness and screening programs...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915694/histology-of-24-organs-from-asian-elephant-calves-elephas-maximus
#5
Chatchote Thitaram, Pitchaya Matchimakul, Wanpitak Pongkan, Wasan Tangphokhanon, Raktham Maktrirat, Jaruwan Khonmee, Anucha Sathanawongs, Piyamat Kongtueng, Korakot Nganvongpanit
Background: Elephants are the largest and heaviest living terrestrial animals, but information on their histology is still lacking. This study provides a unique insight into the elephant's organs and also provides a comparison between juvenile Asian elephants and adult Asian elephants or other species. Here we report on the histological structure of 24 organs, including the skin, brain (cerebrum, cerebellar hemisphere, vermis, thalamus, midbrain), spinal cord, sciatic nerve, striated skeletal muscle, cardiac muscle, bone (flat bone and long bone), cartilage (hyaline cartilage and fibrocartilage), heart (right atrium, right ventricle), blood vessels (aorta, pulmonary artery and caudal vena cava), trunk, trachea, lung, tongue, esophagus, stomach, small intestine (duodenum, jejunum, ileum), large intestine (cecum, colon, rectum), liver and pancreas, kidney, ovary, uterus (body and horn) and spleen of two juvenile Asian elephants...
2018: PeerJ
https://www.readbyqxmd.com/read/29911510/mixed-adenoneuroendocrine-carcinoma-of-the-colon-and-rectum
#6
S Qiu, G Pellino, O J Warren, S Mills, R Goldin, C Kontovounisios, P P Tekkis
Mixed adenoneuroendocrine carcinoma (MANEC) are rare cancers of the gastrointestinal (GI) and pancreatobiliary tract. They are characterized by the presence of a combination of epithelial and neuroendocrine elements, where each component represents at least 30% of the tumour. Review of literature and consolidation of clinicopathological data. Sixty-one cases of colorectal MANEC have been reported in literature and one seen in this centre. The median age of the patients affected was 61.9 ± 12.4 years (20-94 years)...
June 17, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29909745/professor-william-wayne-babcock-1872-1963-and-his-innovations-in-surgery
#7
Konstantinos Laios
Professor William Wayne Babcock (1872-1963) is considered as a leading figure of American surgery during early 20th century. He introduced many innovative surgical techniques such as Babcock operation for the treatment of varicose veins, the Babcock-Bacon operation for the treatment of cancer of the rectum and sigmoid colon preserving anal sphincters, the "soup bone" cranioplasty technique, and the nerve disassociation technique for the relief of certain forms of paralysis or parasthesia due to injury or inflammation...
June 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29901698/association-of-dietary-insulinemic-potential-and-colorectal-cancer-risk-in-men-and-women
#8
Fred K Tabung, Weike Wang, Teresa T Fung, Stephanie A Smith-Warner, NaNa Keum, Kana Wu, Charles S Fuchs, Frank B Hu, Edward L Giovannucci
Background: Insulin response may be important in colorectal cancer development. Diet modulates insulin response and may be a modifiable factor in colorectal cancer prevention. Objective: We examined associations between hyperinsulinemic diets and colorectal cancer risk with the use of an empirical dietary index for hyperinsulinemia (EDIH), a food-based index that characterizes dietary insulinemic potential on the basis of circulating C-peptide concentrations. Design: Diet was assessed every 4 y with food-frequency questionnaires in 46,210 men (Health Professionals Follow-Up Study, 1986-2012) and 74,191 women (Nurses' Health Study, 1984-2012) to calculate EDIH scores...
June 12, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29897392/representation-of-obese-participants-in-obesity-related-cancer-randomized-trials
#9
E Pestine, A Stokes, L Trinquart
Background: Obesity is a risk factor for numerous cancer types, and may influence cancer treatment outcomes. Underrepresentation of obese patients in obesity-related cancer randomized controlled trials (RCTs) may affect generalizability of results. We aimed to assess the reporting of information about eligibility and enrollment of obese participants in obesity-related cancer RCTs. Methods: We conducted a systematic review of RCTs of 10 obesity-related cancer types (esophagus, colon/rectum, liver, gallbladder, pancreas, postmenopausal breast, endometrium, ovary, kidney, and thyroid cancer)...
April 20, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29896400/carcinoma-in-the-residual-rectum-of-a-long-standing-crohn-s-disease-patient-following-subtotal-colectomy-a-case-report
#10
Kazuaki Shibuya, Shigenori Homma, Tadashi Yoshida, Yosuke Ohno, Nobuki Ichikawa, Hideki Kawamura, Teppei Imamoto, Yoshihiro Matsuno, Akinobu Taketomi
The development of colorectal cancer in long-standing Crohn's disease (CD) patients has become a major complication. Therapeutic guidelines for CD-associated cancer (CDAC) have already been established in Western countries; however, specific guidelines are not currently available in Japan. Surveillance of the residual intestine for cancer screening is important for long-standing CD patients. The present case report describes the occurrence of rectal carcinoma in a patient with a 25-year history of CD. A 37-year-old male with a 17-year history of CD underwent semi-emergent subtotal colectomy and ileostomy for bowel obstruction secondary to the transverse colon stenosis, and multiple severe stenosis and inflammation...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29894583/prognostic-value-and-characteristics-of-n1c-colorectal-cancer
#11
Morgane Bouquot, Ben Creavin, Nicolas Goasguen, Najim Chafai, Emmanuel Tiret, Thierry André, Jean-Francois Flejou, Yann Parc, Jérémie H Lefevre, Magali Svrcek
The presence of tumor deposits (TD) in colorectal cancer (CRC) is associated with poor prognosis. The 7th edition of TNM subclassified a new nodal stage, N1c, characterized by the presence of TD without any concurrent positive lymph node (LN). It is not clear if the N1c category is equal or not to LN metastasis. We aimed to examine the prevalence, characteristics and prognostic significance of this new subcategory METHODS: Consecutive patients who underwent surgery for CRC in two centers (2011-2014) were analyzed...
June 12, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29892169/assessment-of-colonic-contents-in-patients-with-chronic-constipation-using-mri
#12
Yumi Inoh, Kenji Kanoshima, Kanji Ohkuma, Akiko Fuyuki, Shiori Uchiyama, Hidenori Ohkubo, Takuma Higurashi, Hiroshi Iida, Takashi Nonaka, Koji Fujita, Akihiko Kusakabe, Masahiko Inamori, Kazumasa Hiroishi, Hajime Nagase, Atushi Nakajima, Taro Takahara
Although chronic constipation is common, colonic functional evaluating tests are uncommon. This study examines whether chronic constipation and gastrointestinal symptoms are correlated with the lateral diameter of the colon measured from MRI images. We included chronic constipation patients in a prospective, cross-sectional study using MRI at three centers. We divided 3D MRI colorectal images into 6 segments using with specified sequences and selected the maximum luminal diameter from each segment. We used the GSRS questionnaire to evaluate gastrointestinal symptoms...
May 2018: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/29884570/colorectal-cancer-survival-at-an-oncologic-center-in-colombia-a-historic-cohort-study
#13
S M Campo-Sánchez, J Camargo-Trillos, J A Calle-Ramírez, L R Gómez-Wolff, L A Sánchez-Patiño, H I García-García
INTRODUCTION AND AIMS: In Colombia, cancer of the colon is the third most frequent cancer in relation to incidence and mortality. Five-year survival depends on stage at diagnosis, albeit that rate is not known for the country. The aim of the present study was to characterize the overall survival and disease-free survival rates in an adult population with colorectal cancer treated at an oncology center in Medellín, Colombia. MATERIALS AND METHODS: A retrospective cohort study was conducted...
June 5, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29882196/prone-positioning-on-a-belly-board-decreases-rectal-and-bowel-doses-in-pelvic-intensity-modulated-radiation-therapy-imrt-for-prostate-cancer
#14
Renáta Kószó, Linda Varga, Emese Fodor, Zsuzsanna Kahán, Adrienne Cserháti, Katalin Hideghéty, Zsófia Együd, Csilla Szabó, Emőke Borzási, Dorottya Szabó, Kitti Müllner, Zoltán Varga, Anikó Maráz
The presence of normal tissues in the irradiated volume limits dose escalation during pelvic radiotherapy (RT) for prostate cancer. Supine and prone positions on a belly board were compared by analyzing the exposure of organs at risk (OARs) using intensity modulated RT (IMRT). The prospective trial included 55 high risk, localized or locally advanced prostate cancer patients, receiving definitive image-guided RT. Computed tomography scanning for irradiation planning was carried out in both positions. Gross tumor volume, clinical and planning target volumes (PTV) and OARs were delineated, defining subprostatic and periprostatic rectal subsegments...
June 7, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29880626/-campylobacter-jejuni-and-pseudomonas-coinfection-in-the-setting-of-ulcerative-colitis
#15
John Paul Iguidbashian, Jai D Parekh, Shweta Kukrety, Venkata Giri Andukuri
A 66-year-old woman presented with 2 days of fever and severe diarrhoea. She has a history of ulcerative colitis (UC), well controlled with medication. She also has a history of Ehlers-Danlos syndrome, infective endocarditis following aortic valve replacement and pulmonary embolism. She had complained of passing stool with traces of blood about 30 times per day. Stool testing for Clostridium difficile, routine culture and microscopy was done. She was started on ceftriaxone. CT scan revealed thick-walled colon consistent with UC flare...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29878679/session-1-colon-cancer-10-years-behind-the-rectum
#16
V Tudyka, R Madoff, A Wale, S Laurberg, H Yano, G Brown
The improvements in surgical technique brought about by the widespread adoption of total mesorectal excision plane dissection in rectal cancer has substantially improved survival and recurrence rates from this disease. For the first time in 50 years, the outcomes in rectal cancer have overtaken those of colon cancer. Professor Madoff's overview lecture and the experts' round table discussion address whether applying the surgical principles already achieved in rectal cancer can meet with similar success in colon cancer, how this can be achieved and the challenges we face...
May 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29873077/anatomical-subsite-can-modify-the-association-between-meat-and-meat-compounds-and-risk-of-colorectal-adenocarcinoma-findings-from-three-large-us-cohorts
#17
Arash Etemadi, Christian C Abnet, Barry I Graubard, Laura Beane- Freeman, Neal D Freedman, Linda Liao, Sanford M Dawsey, Rashmi Sinha
Distal and proximal colon tumors have distinct incidence trends and embryonic origins; whether these sub-sites have distinct susceptibilities to known risk factors is unclear. We used pooled data from 407,270 participants in three US-based studies, with overall median follow-up of 13.8 years. We used adjusted Cox models to analyze the association between dietary intakes (from diet history questionnaire) of total, processed and unprocessed red meat; total white meat, poultry and fish; and meat-related compounds: heme iron, nitrate, nitrite, the heterocyclic amines (HCAs), and benzo(a)pyrene (B(a)P) and incidence of colorectal cancer subsites...
June 6, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29868623/transplantation-of-ccr5%C3%A2-32-homozygous-umbilical-cord-blood-in-a-child-with-acute-lymphoblastic-leukemia-and-perinatally-acquired-hiv-infection
#18
Meghan Rothenberger, John E Wagner, Ashley Haase, Douglas Richman, Bartosz Grzywacz, Matthew Strain, Steven Lada, Jacob Estes, Courtney V Fletcher, Anthony T Podany, Jodi Anderson, Thomas Schmidt, Steve Wietgrefe, Timothy Schacker, Michael R Verneris
Background: Allogeneic hematopoietic cell transplantation (allo-HCT) in a CCR5∆32 homozygous donor resulted in HIV cure. Understanding how allo-HCT impacts the HIV reservoir will inform cure strategies. Methods: A 12-year-old with perinatally acquired, CCR5-tropic HIV and acute lymphoblastic leukemia underwent myeloablative conditioning and umbilical cord blood (UCB) transplantation from a CCR5∆32 homozygous donor. Peripheral blood mononuclear cells (PBMCs) and the rectum were sampled pre- and post-transplant...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29867933/dysbiosis-associated-polyposis-of-the-colon-cap-polyposis
#19
Kazuki Okamoto, Tomohiro Watanabe, Yoriaki Komeda, Ayana Okamoto, Kosuke Minaga, Ken Kamata, Kentaro Yamao, Mamoru Takenaka, Satoru Hagiwara, Toshiharu Sakurai, Tomonori Tanaka, Hiroki Sakamoto, Kiyoshige Fujimoto, Naoshi Nishida, Masatoshi Kudo
Cap polyposis is a rare gastrointestinal disease characterized by multiple inflammatory polyps located between the distal colon and the rectum. Despite the lack of clarity regarding its pathogenesis, mucosal prolapse, chronic inflammatory responses, and Helicobacter pylori infection are considered key contributors to the development of this disease entity. Although it is now generally accepted that dysbiosis of gut microbiota is associated with intestinal and extra-intestinal diseases, alterations of intestinal microbiota have been poorly defined in cap polyposis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29866752/risk-of-ischemic-and-hemorrhagic-strokes-in-occult-and-manifest-cancers
#20
Klaus Kaae Andersen, Tom Skyhøj Olsen
BACKGROUND AND PURPOSE: Manifest cancer is associated with increased risk of stroke. The risk of stroke in people with occult cancer in comparison to the risk in the background population without cancer has not been investigated. Smoking is a risk factor for both cancer and stroke, but the role of smoking for the risk of stroke in cancer has not been investigated. METHODS: We identified all incident cases of cancer in Denmark 2003 to 2012 (n=264.376) from the Danish Cancer Registry...
June 4, 2018: Stroke; a Journal of Cerebral Circulation
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