Celestino Sardu, Massimo Massetti, Lucia Scisciola, Maria Consiglia Trotta, Matteo Santamaria, Mario Volpicelli, Valentino Ducceschi, Giuseppe Signoriello, Nunzia D'Onofrio, Ludovica Marfella, Flavia Casolaro, Michele D ' Amico, Antonio Ruocco, Maria Luisa Balestrieri, Ciro Mauro, Concetta Rafaniello, Annalisa Capuano, Giuseppe Paolisso, Raffaele Marfella
OBJECTIVES: We evaluated whether Angiotensin receptor/Neprilysin inhibitors (ARNI) reduce heart failure (HF) hospitalizations and deaths in cardiac resynchronization therapy with defibrillator (CRTd) non-responders patients at 12 months of follow-up, modulating microRNAs (miRs) implied in adverse cardiac remodeling. BACKGROUND: adverse cardiac remodeling characterized by left ventricle ejection fraction (LVEF) reduction, left ventricular end-systolic volume (LVESv) increase, and the 6-minute walking test (6MWT) reduction are relevant pathological mechanisms in CRTd non-responders and could be linked to changes in miRNAs (miRs), regulating cardiac fibrosis, apoptosis, and hypertrophy...
August 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society